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1.
Artigo em Inglês | MEDLINE | ID: mdl-33400389

RESUMO

Studies reported that women in a low-risk cohort with stage 1 hypertension defined as 130-139 mmHg/80-89 mmHg, according to the American College of Cardiology/American Heart Association, are more likely to develop into preeclampsia than women with normotensive in the early gestation. In this study, the authors investigated whether preeclampsia was more likely to occur in stage 1 hypertensive women compared to the normotensive pregnant women in a high-risk cohort, which was based on the randomized controlled trial of "Low-dose Aspirin in the Prevention of Preeclampsia in China." Meanwhile, the authors further evaluated the preventive effect of aspirin for preeclampsia in stage 1 hypertension subset. In women enrolled at or before 16 weeks of gestation, in the control group, the preeclampsia occurrence was significantly higher in stage 1 hypertensive woman than in the normotensive women (20.4% vs. 6.2%, aOR 3.960, 95% CI 1.299-12.074, p = .016), while no difference was observed in the aspirin group (4.5% vs. 4.2%, aOR 0.921, 95% CI 0.140-6.070, p = .932). In stage 1 hypertension, the incidences of preeclampsia and preterm birth were significantly lower in the aspirin group as compared to the control group (4.5% vs. 20.4%, aOR 0.139, 95% CI 0.027-0.716, p = .018; 4.5% vs. 18.4%, aOR 0.141, 95% CI 0.025-0.782, p = .025). Compared with the control group, the aspirin group displayed significantly prolonged gestational age at delivery (38.6 ± 1.2 vs. 37.4 ± 3.4, p = .042). This study indicates that the newly classified stage 1 hypertension might be an additional risk factor for preeclampsia in Chinese high-risk pregnant women, and aspirin intervention might be useful.

2.
Compr Rev Food Sci Food Saf ; 20(1): 1075-1100, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33443809

RESUMO

In recent years, starch-based nanoparticles have attracted great interest due to their small size, good biocompatibility, and environmental friendliness, as well as their potential applications in foods, drug delivery carriers, and biodegradable edible films. Compared with nonstarch polysaccharides, starch can be enzymatically hydrolyzed into glucose in vivo, so it can be used as an enzyme-responsive carrier. The recent research progress of starch-based nanoparticles, including starch nanoparticles, starch nanospheres, starch micelles, starch vesicles, starch nanogels, and starch nanofibers, are reviewed in this paper. The main focus is on their responsiveness, digestibility, toxicity, interactions with other components, and applications. Starch-based nanoparticles are nontoxic and responsive to pH, temperature, light, and other stimuli. It can interact with proteins, antioxidants, and lipids through electrostatic interactions and hydrogen bonding interactions. Starch-based nanoparticles have a wide range of applications, including enhancing the mechanical properties of films and gels, stabilizing emulsions, as a fluorescent indicator, a catalyst, and a nanocarrier to control the release of active ingredients and drugs.

3.
Int J Biol Macromol ; 2020 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-33278451

RESUMO

Recently, amylose-lipid complexes have attracted widespread attention because of their various applications. However, DBS complexed with fatty acids of different carbon chain length are rarely studied. This study aimed to probe the complexation of DBS with saturated fatty acids having different carbon chain lengths (C6-C18). The results revealed that DBS was able to form V-type complexes with all the fatty acids considered. Compared to DBS, the relative crystallinity of the complexes increased 2-3 times. DBS with lauric acid and myristic acid formed three types V-type complexes (type I, type IIa, and type IIb). The complexing index followed the order of hexanoic acid > octanoic acid > capric acid > lauric acid > myristic acid > palmitic acid > stearic acid. Furthermore, lauric acid and myristic acid formed complexes with DBS more easily compared with other fatty acids.

4.
J Ophthalmol ; 2020: 6287274, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32802488

RESUMO

Purpose: To evaluate the safety and outcomes of primary posterior continuous curvilinear capsulorhexis (PPCCC) combined with phacoemulsification in postvitrectomy eyes. Design: Retrospective case series. Methods: Twenty-one postvitrectomy eyes of 21 patients with cataract between April 2017 and December 2019 were enrolled. PPCCC through the cornea incision was performed before in-the-bag intraocular lens implantation. All patients were followed up for at least 3 months postoperatively. The outcome measures were corrected distance visual acuity (CDVA), intraocular pressure (IOP), corneal endothelium cell counts (CECC), central macular thickness (CMT), the occurrence of intraoperative or postoperative complications, and the incidence of posterior capsular opacification (PCO). Results: The mean age was 56.14 ± 9.76 years (ranging from 31 to 68). The mean Snellen CDVA was 20/400 preoperatively and improved to 20/67 postoperatively (P < 0.001). No significant differences were found between IOP (P = 0.96) and CMT (P = 0.42) preoperatively and postoperatively. The mean CECC was 2571.8 ± 319.3 cells/mm2 preoperatively and 2498.2 ± 346.3 cells/mm2 postoperatively (P < 0.05). Lens epithelium cells proliferation was confined to the peripheral capsular bag during a mean follow-up of 12.9 ± 10.5 months (ranging from 3 to 28 months). Intraoperative posterior capsule extension occurred in 1 eye (4%), although it did not affect the patient's vision. No serious complications, including retinal detachment or endophthalmitis, were detected in any of the 21 cases. Conclusion: PPCCC through cornea incision combined with phacoemulsification may be a safe and practical alternative to prevent PCO in postvitrectomy eyes with cataract.

5.
J Nanobiotechnology ; 18(1): 86, 2020 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-32513194

RESUMO

Hepatic stellate cells (HSCs) were activated and secreted excessive amounts of extracellular matrix (ECM) proteins during pathogenetic progress of liver fibrosis. Germacrone (GMO) and miR-29b can play an important role in inhibiting growth of HSCs and production of type I collagen. GMO and miR-29b were co-encapsulated into nanoparticles (NPs) based on poly(ethylene glycol)-block-poly(lactide-co-glycolide) (PEG-PLGA). Then, NPs were modified with cyclic RGD peptides (cRGDfK). cRGDfK is an effective ligand to bind integrin αvß3 and increase the targeting ability for fibrotic liver. GMO- and miR-29b-loaded NPs exhibited great cytotoxicity to activated HSCs and significantly inhibited production of type I collagen. Liver fibrosis model of mice was induced by administration of carbon tetrachloride. Great targeting ability was achieved in liver fibrotic mice treated with cRGD-modified NPs. Significant ant-fibrotic effects have been presented based on hematoxylin and eosin (H&E), Masson and Sirius Red staining results of liver tissues collected from mice treated with drug-loaded NPs. All these results indicate GMO- and miR-29b-loaded cRGD-modified NPs have the potential for clinical use to treat liver fibrosis.

6.
Int J Biol Macromol ; 153: 341-348, 2020 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-32142850

RESUMO

After gelatinization, starch is prone to retrograde during storage, and it is a notorious challenge to inhibit starch retrogradation in papermaking, textile, and construction fields. This work aimed to develop a new method for inhibiting the retrogradation of normal corn starch (CS) and waxy corn starch (WCS) by sodium borohydride (NaBH4). Differential scanning calorimetry analysis suggested that addition of 2.0% (at dry starch basis, w/w) NaBH4 can completely inhibit WCS retrogradation. X-ray diffraction results showed that, as the NaBH4 concentration increased, the crystallinity of CS and WCS gradually decreased. After seven days of storage at 4 °C, the relative crystallinity of CS and WCS with 2.0% NaBH4 decreased by 62.22% and 100%, respectively. Low field nuclear magnetic resonance analysis showed that the incorporation of NaBH4 remarkably affected the change of relaxation time(T2). The T2 changes in the gelatinized CS and WCS with 2.0% NaBH4 were much lower than gelatinized CS and WCS without NaBH4. The addition of NaBH4 led to a reduction in the hydrogen bonding of CS and WCS, which was confirmed by Fourier transform infrared spectroscopy (FTIR). It was concluded that the addition of 2.0% NaBH4 can significantly inhibit the retrogradation of CS and WCS.

7.
J Ethnopharmacol ; 246: 111768, 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-30849507

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Curcuma wenyujin Y.H. (CW), a variety of Curumae Rhizoma, which documented in China Pharmacopeia, has long been used as plant medicine for its traditional effect on promoting Qi, activating blood stagnation and expelling blood stasis. Nowadays, it is often used in clinic for extraordinary effect on liver diseases. It is worthy to be noted that CW processed with vinegar has been applied in clinic for 1500 years which started in the northern and southern dynasties. AIM OF STUDY: Liver fibrosis is a worldwide clinical issue. It is worth developing a multi-target and multicellular approach which is high efficiency and low side effects for the treatment of hepatic fibrosis. The anti-hepatic fibrosis molecular mechanisms of CW and vinegar Curcuma wenyujin (VCW) need to be explored and elucidated. Furthermore, the study aimed to discuss the efficiency and mechanism differences between CW and VCW in hepatic fibrosis. METHODS AND RESULTS: Biochemical assays and histopathology were adopted to evaluate the anti-hepatic fibrosis effect of CW and VCW. The TGF-ß/Smad signaling involving TGF-ß1, TGF-ßRⅠ, TGF-ßRⅡ and Smad2, Smad3, Smad7 in fibrosis is examined, which is a critical step towards the evaluation of anti-hepatic fibrosis agents. Meanwhile, the MMP/TIMP balance is a potential therapy target by modulating extracellular matrix, which is also examined. Both CW and VCW inhibit the activation and proliferation of hepatic stellate cells and induce apoptosis via blocking TGF-ß/Smad signaling pathways. Additionally, the level of MMP-2/TIMP-1 regulated significantly, which suggest CW and VCW participate in the degradation process, and maintain the formation and production of extracellular matrix. CONCLUSION: Raw and vinegar processed Curcuma wenyujin regulates hepatic fibrosis via bloking TGF-ß/Smad signaling pathways and up-regulation of MMP-2/TIMP-1 ratio. And VCW has more exhibition than CW.


Assuntos
Curcuma , Cirrose Hepática/metabolismo , Extratos Vegetais/farmacologia , Ácido Acético/química , Animais , Linhagem Celular , Fígado/efeitos dos fármacos , Fígado/patologia , Cirrose Hepática/genética , Cirrose Hepática/patologia , Masculino , Metaloproteinase 2 da Matriz/genética , Metaloproteinase 2 da Matriz/metabolismo , Ratos Sprague-Dawley , Transdução de Sinais/efeitos dos fármacos , Proteína Smad2/genética , Proteína Smad2/metabolismo , Proteína Smad3/genética , Proteína Smad3/metabolismo , Inibidor Tecidual de Metaloproteinase-1/genética , Inibidor Tecidual de Metaloproteinase-1/metabolismo , Fator de Crescimento Transformador beta1/genética , Fator de Crescimento Transformador beta1/metabolismo
8.
Toxicol Appl Pharmacol ; 386: 114813, 2020 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-31715269

RESUMO

Pristimerin, a triterpenoid, has exhibited potential anti-inflammatory and anti-tumor activities. Nevertheless, the role and mechanism of pristimerin in intestinal inflammation and colon cancer require further investigation. Here, we found that pristimerin protected mice from dextran sulfate sodium (DSS)-induced colitis, restoring epithelial damage and reducing tissue inflammation and inflammatory cell infiltration. In addition, pristimerin dramatically reduced the number and size of the tumors in a azoxymethane (AOM)/DSS-induced colitis-associated colorectal cancer (CAC) model. Furthermore, we found that pristimerin suppressed Wnt/ß-catenin signaling by RNA-Seq. Pristimerin inhibited Wnt/ß-catenin signaling via activation of GSK3ß, thereby suppressing Wnt target gene expression in colon cancer HCT116 and HT-29 cells. In HCT116 colon cancer xenografts and APCmin/+ mice, which undergo spontaneous intestinal tumorigenesis, administration of pristimerin reduced the tumor progression and decreased the expression of phosphorylated GSK3ß Ser 9, ß-catenin, cyclin D1 and c-Myc. These results suggest that pristimerin is a potent agent for preventing colon inflammation and carcinogenesis.


Assuntos
Antineoplásicos/uso terapêutico , Neoplasias Colorretais/tratamento farmacológico , Inflamação/tratamento farmacológico , Triterpenos/uso terapêutico , Via de Sinalização Wnt/efeitos dos fármacos , Animais , Modelos Animais de Doenças , Feminino , Glicogênio Sintase Quinase 3 beta/antagonistas & inibidores , Células HCT116 , Células HT29 , Humanos , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C57BL , Transplante de Neoplasias
9.
Cell Death Discov ; 5: 125, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31396402

RESUMO

Breast cancer is the most common malignant tumor in women, and progress toward long-term survival has stagnated. Pristimerin, a natural quinonemethide triterpenoid, exhibits potential anti-tumor effects on various cancers. However, the underlying mechanism remains poorly understood. In this study, we found that pristimerin reduced the viability of breast cancer cells in vitro and the growth of xenografts in vivo, and these reductions were accompanied by thioredoxin-1 (Trx-1) inhibition and ASK1 and JNK activation. The results showed that pristimerin inhibited cell cycle progression and triggered cell apoptosis and autophagy. Furthermore, we found that the generation of reactive oxygen species (ROS) was a critical mediator in pristimerin-induced cell death. Enhanced ROS generation by pristimerin activated the ASK1/JNK signaling pathway. Inhibition of ROS with N-acetyl cysteine (NAC) significantly decreased pristimerin-induced cell death by inhibiting the phosphorylation of ASK1 and JNK. Taken together, these results suggest a critical role for the ROS/ASK1/JNK pathway in the anticancer activity of pristimerin.

10.
Nanoscale ; 11(16): 8037-8046, 2019 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-30968086

RESUMO

Tuning the morphology and structural evolution of metal nanoparticles to expose specific crystal facets in a certain reaction atmosphere is conducive to designing catalysts with a high catalytic activity. Herein, coverage dependent hydrogen adsorption on seven fcc Ru surfaces was investigated using density functional theory (DFT) calculations. The morphology evolution of the fcc Ru nanoparticles under the reactive environment was further illustrated using the multiscale structure reconstruction (MSR) model, which combines the DFT results with the Fowler-Guggenheim (F-G) adsorption isotherm and the Wulff construction. At constant pressure, the shape of a fcc Ru nanoparticle changes from a rhombic dodecahedron to a truncated octahedron with an increase of the temperature. More importantly, the desired Ru morphology, with abundant open facets, was predicted to occur at a high temperature and low pressure. Our results provide an insightful understanding of the reshaping of Ru nanoparticles during real reactions, which is crucial for its rational design for use as a nanocatalyst.

11.
Langmuir ; 34(34): 10187-10196, 2018 08 28.
Artigo em Inglês | MEDLINE | ID: mdl-30074798

RESUMO

Polymer/metal oxide composites are promising candidates for the treatment of water pollution. Adsorption selectivity as well as a large adsorption capacity are two key factors for treating wastewater containing multiple ions. Herein, a PPy+/TiO2(O-) composite with a heterojunction structure was first discovered to have novel selectivity toward heavy metal ions. An interesting self-doping nature of TiO2(O-) together with SO42- for PPy+ was reported. This interesting structure contributed to an impressive selective adsorption capability with an ascending order of Zn2+ > Pb2+ ≫ Cu2+ in a ternary ion system, where the adsorption for Cu2+ could be almost suppressed. Through the designed adsorption experiments and characterization techniques including Fourier transform infrared, thermogravimetric analysis, and X-ray photoelectron spectroscopy, a universal synergistic mechanism for PPy+/TiO2(O-) composite was first proposed and confirmed. The doping and dedoping of metal oxide (dopant) from the polymer dictates the adsorption selectivity, where the selectivity is determined by the interaction between TiO2 and heavy metal ions. This work may provide some useful guidelines for designing adsorbents with selectivity toward specific heavy metal ions.

12.
Nanoscale Res Lett ; 12(1): 588, 2017 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-29124414

RESUMO

In recent years, BiVO4 has drawn much attention as a novel photocatalyst given its excellent ability to absorb visible light. This work reports the development of Ag-modified BiV1-xMoxO4 composites through a facile hydrothermal synthesis with the subsequent photoinduced reduction of Ag+ at almost neutral pH conditions. Metallic Ag nanoparticles were deposited on the (040) facet of Mo-doped BiVO4 powders. The crystal structure and morphology of the as-prepared samples were studied by XRD and SEM analyses. Moreover, the photocatalytic performance of BiVO4, Ag/BiVO4, and Ag-modified BiV1-xMoxO4 were evaluated by the degradation of rhodamine B (RhB). The Ag/BiV0.9925Mo0.0075O4 composite exhibited the most efficient photocatalytic performance. The present work provides greater insight into the application of BiVO4 in the field of photocatalysis.

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