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1.
PLoS One ; 15(1): e0227408, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31940393

RESUMO

Pepsin plays an important role in laryngopharyngeal reflux (LPR), a risk factor for the development of hypopharyngeal squamous cell carcinomas (HPSCC). However, the role of pepsin in HPSCC is not clear. We show by immunohistochemistry that pepsin positivity occurs in a significant proportion of human primary HPSCC specimens, and in many cases matched adjacent uninvolved epithelia are negative for pepsin. Pepsin positivity is associated with nodal involvement, suggesting that pepsin may have a role in metastasis. Treatment of FaDu cancer cells with pepsin increased cell proliferation, possibly by inducing G1/S transition. We also observed significant changes in expression of genes involved in NF-kappaB, TRAIL and Notch signaling. Our data suggest that pepsin plays an important role in HPSCC and that targeting pepsin could have potential therapeutic benefits.

2.
Chemosphere ; 244: 125498, 2019 Nov 27.
Artigo em Inglês | MEDLINE | ID: mdl-31812049

RESUMO

BACKGROUND: Heavy metal exposure induces oxidative stress, which is critical for adverse male reproductive health. OBJECTIVE: To explore the mediating effect of oxidative stress on the relationship of heavy metal exposure with semen quality. METHODS: Urinary levels of three oxidative stress markers, semen quality, and urinary arsenic, cadmium and lead were examined among 1020 men. Multivariate linear regression was applied to explore cross-sectional associations, and the role of oxidative stress as mediators was investigated. RESULTS: Quartiles of metals showed significant dose-dependent relationships with increasing levels of 8-hydroxy-2deoxyguanosine (8-OHdG), 8-iso-prostaglandin F2α (8-isoPGF2α) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA). Significant or suggestive associations were also found between urinary 8-OHdG levels and the percentage of normal sperm morphology (ptrend < 0.001), between urinary 8-isoPGF2α levels and total motility (ptrend = 0.052), progressive motility (ptrend = 0.050) respectively. The mediation analysis showed that about 14.59%, 18.06%, 15.35% or 16.49% of the association between arsenic/cadmium exposure and the decreased total motility/progressive motility was mediated by 8-isoPGF2α, respectively. In addition, about 16.47% of the relationship between lead exposure and the decreased percentage of normal sperm morphology was mediated by 8-OHdG. CONCLUSIONS: Our findings suggest that higher urinary arsenic, cadmium and lead levels were associated with increased oxidative stress markers, which also related with altered semen quality. 8-isoPGF2α and 8-OHdG might be the possible mediators of the associations between urinary heavy metals and total motility, progressive motility or the proportion of normal sperm morphology.

3.
Materials (Basel) ; 12(22)2019 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-31726701

RESUMO

Sn-0.7Cu-0.075Al solder alloy adding with Ce and La had been successfully prepared by applying ball-milling and vacuum arc remelting. The influence of Ce and La on microstructure and corrosion behavior of Sn-0.7Cu-0.075Al solder alloy was investigated. The results showed that Ce (La)-containing solders had refined grains and obvious directional tendency due to the dispersive refiner (CeO2 and La2O3). Electrochemical potentiodynamic curves revealed three different stages of the reaction, including anodic and cathodic processes, prepassivation section, and stable passivation stages. The self-corrosion potential (Ecorr) of alloys with Ce and La addition were a little bit more negative, hardly making a difference on corrosion occurrence. However, the corrosion current density (Icorr) and passivation current density (Ip) decreased by two-thirds and one-half respectively, which indicated a better corrosion resistant after adding rare earths. The recorded micrographs of corroded surface at different polarized points witnessed the formation of corrosion product film both on prepassivation and passivation stage. Moreover, the cross section of corrosion product film showed the coarse, loose film in Sn-0.7Cu-0.075Al solder and adherent, compact film in Ce (La)-containing solders, which further indicated an excellent anti-corrosion property.

4.
Sci Total Environ ; 697: 134051, 2019 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-31487586

RESUMO

BACKGROUND: The intricate association of mortality risk with ambient air pollution and temperature is of growing concern. Little is known regarding effect of changes in season and temperature on daily cardiovascular mortality associated with air pollutant nitrogen dioxide (NO2). OBJECTIVES: Our study aimed to assess the effect of NO2 on cardiovascular mortality modified by season and daily air temperature in the effect, and further to identify the population highly susceptible to cardiovascular mortality associated with NO2 and air temperature. METHODS: We collected daily cause-specific death data, weather conditions, and air pollutant concentrations in Shenzhen from 2013 to 2017. Distributed-lag linear models were employed to analyze the effect of season on the NO2-associated mortality. Furthermore, generalized additive models were combined with stratification parametric analysis to estimate the interaction effect of NO2 with air temperature on cardiovascular mortality. RESULTS: In the cold season, the percentage increase in daily mortality for every 10 µg/m3 increment in NO2 concentration over lags of 0-2 days was 4.45% (95% CI: 2.71-6.21%). However, no statistically significant effect of NO2 was observed in the warm season. Compared with high-temperature days (>median temperature), a 3.51% increase in mortality (95% CI: 2.04-5.01%) over low-temperature days (≤median temperature) for the same increase in NO2 was significant. Air temperature modified the effect of NO2 on daily mortality by 4.08% (95% CI: 2.28-5.91%) for the elderly (age ≥ 65 years) on low-temperature days vs. -0.82% (95% CI: -3.88-2.34%) on high-temperature days, and 3.38% (95% CI: 1.50-5.29%) for males on low-temperature days vs. -0.73% (95% CI: -3.83-2.47%) on high air temperature days. CONCLUSIONS: The cold season and low temperatures could significantly enhance the effect of NO2 on cardiovascular mortality. The elderly and males suffering from cardiovascular disease should take precautions against low temperature and NO2 air pollution.


Assuntos
Poluentes Atmosféricos/análise , Poluição do Ar/estatística & dados numéricos , Doenças Cardiovasculares/mortalidade , Exposição Ambiental/estatística & dados numéricos , Dióxido de Nitrogênio/análise , Temperatura Ambiente , Idoso , Causas de Morte , China/epidemiologia , Feminino , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Tempo (Meteorologia)
5.
Mol Med Rep ; 20(3): 2609-2616, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31322239

RESUMO

The aim of the present study was to elucidate the role of the non­syndromic autosomal recessive deafness 12 allelic variant of cadherin 23 (CDH23) in Chinese patients with non­syndromic hearing loss. The present study focused on a Chinese family with hearing loss in which there were two siblings with autosomal, recessive deafness, ranging from severe to profound hearing loss over all frequencies. DNA sequencing was used to assess the genetic factors in the disease etiology. The data revealed a compound heterozygous mutation of CDH23 in both patients. Genetic CDH23 variants are known to be responsible for non­syndromic hearing loss, and CDH23 variants frequently occur in various populations, including Japanese and Republic of Korean. Results from the present study, indicated a significant contribution of CDH23 variants to the non­syndromic hearing loss in Chinese patients.


Assuntos
Caderinas/genética , Perda Auditiva Neurossensorial/genética , Adolescente , Sequência de Aminoácidos , Grupo com Ancestrais do Continente Asiático/genética , Caderinas/química , Feminino , Perda Auditiva/genética , Heterozigoto , Humanos , Masculino , Modelos Moleculares , Mutação , Linhagem , Alinhamento de Sequência , Irmãos , Adulto Jovem
6.
Artigo em Inglês | MEDLINE | ID: mdl-30708969

RESUMO

Background: China is at its most important stage of air pollution control. Research on the association between air pollutants and human health is very important and necessary. The purpose of this study was to evaluate the association between PM2.5 concentrations and residents' mortality and to compare the effect of PM2.5 on the different diseases, accidental deaths, sex or age of residents from high polluted areas with less polluted areas. Methods: The semi-parametric generalized additive model (GAM) with Poisson distribution of time series analysis was used. The excess risk (ER) of mortality with the incremental increase of 10 µg/m³ in PM2.5 concentration was calculated. Concentration-response relationship curves and autocorrelation between different lags of PM2.5 were also evaluated. Results: PM2.5 exposure was significantly associated with the mortality of residents. The strongest ERs per 10 µg/m³ increase in PM2.5 were 0.74% (95% CI: 0.11⁻1.38%) for all-cause, 0.67% (95% CI: 0.01⁻1.33%) for non-accidental, 1.81% (95% CI: 0.22⁻3.42%) for accidental, 3.04% (95% CI: 0.60⁻5.55%) for total respiratory disease, 6.38% (95% CI: 2.78⁻10.11%) for chronic lower respiratory disease (CLRD), 8.24% (95% CI: 3.53⁻13.17%) for chronic obstructive pulmonary disease (COPD), 1.04% (95% CI: 0.25⁻1.84%) for male and 1.32% (95% CI: 0.46⁻2.19%) for elderly. Furthermore, important information on the concentration-response relationship curves was provided. Conclusions: PM2.5 can increase the risk of residents' mortality, even in places with less air pollution and developed economy in China.


Assuntos
Poluentes Atmosféricos/toxicidade , Exposição por Inalação/efeitos adversos , Exposição por Inalação/estatística & dados numéricos , Mortalidade , Material Particulado/toxicidade , Poluentes Atmosféricos/química , China , Cidades , Relação Dose-Resposta a Droga , Humanos , Tamanho da Partícula , Material Particulado/química , Distribuição de Poisson
7.
Water Sci Technol ; 80(9): 1683-1691, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32039900

RESUMO

The pollution from nuclear leaks and nuclear disasters (e.g. radioactive iodine) would cause serious harm to human beings and ecosystems for many years. Cocoon silk and deep eutectic solvents (DESs) are both green substances. DESs are easily synthesized, cheap, highly biocompatible and highly biodegradable. Here, we combine the removal of organic dyes and the capture of radioactive iodine by using green DES-pretreated cocoon silk. It is the first time organic dyes have been removed from wastewater by DES-disrupted silk for the purpose of favourably removing iodine. Organic dyes-captured DES-pretreated cocoon silk could be used to capture iodine efficiently. It opens a new route to dispose of one waste from nuclear energy with organic dyes from wastewater captured by green solvents-pretreated natural silk.

8.
J Gen Psychol ; 145(4): 415-430, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30457038

RESUMO

Many previous studies have demonstrated the SNARC effect-i.e., participants are faster to respond with their left/right hand to small/large numbers. However, there is a debate on whether it is based on working or long-term memory (i.e., relative or absolute magnitude). Here, we examined the flexibility of the spatial-numerical associations using orientation judgment tasks. Participants were asked to judge the orientation of a rotated frame surrounding an Arabic digit under numerical ranges 1-6, 4-9 (Experiment 1), and 1-9 (Experiment 2). The task difficulty was manipulated by rotating stimuli. We observed a significant SNARC effect for range 1-6 and a reversed SNARC effect for 4-9, regardless of the total numerical range presented in the task. Furthermore, the SNARC effect became more salient with increasing task difficulty. Our results suggest that the SNARC effect is based on the absolute magnitude of digits, supporting the long-term memory explanation.


Assuntos
Cognição/fisiologia , Julgamento/fisiologia , Percepção Espacial/fisiologia , Feminino , Humanos , Masculino , Matemática , Testes Neuropsicológicos , Tempo de Reação/fisiologia , Adulto Jovem
9.
Environ Sci Pollut Res Int ; 25(36): 36239-36255, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30367425

RESUMO

Extreme temperature has been reported to be associated with an increase in acute disease incidence in several cities. However, few similar studies were carried out in Shenzhen, which is a subtropical city located in the southern China. This study explored the relationship between the emergency incidences and extreme temperatures, and investigated the role of air pollutants played in the temperature-related effects on human health in Shenzhen. We conducted a distributed lag nonlinear model study on the effect of extreme temperatures on emergency incidences in Shenzhen city during 2013-2017. Here, only the total emergency incidences, emergency incidences for respiratory diseases, and cardiovascular diseases were taken into consideration. Air pollution, subgroups, and seasons were adjusted to investigate the impacts of extreme temperatures on emergency incidences. Relative risk (RR) and 95% confidence intervals were calculated with the R software. From lag 0 to 21 days, the RR of temperature-total emergency department visits, temperature-cardiovascular, and temperature-respiratory diseases was 1.09 (95% CI: 0.98-1.20), 1.22 (95% CI: 0.96-1.56), and 1.06 (95% CI: 0.70-1.60) at extremely low temperature (first percent of temperature, 10 °C), respectively. During the same lag days, the RR was 1.02 (95 % CI: 0.92-1.14), 0.64 (95% CI: 0.49-0.86), and 0.92 (95% CI: 0.56-1.53) between extremely high temperature and total emergency department visits, cardiovascular, and respiratory diseases, respectively. The cumulative effects gradually went up with time for all types of emergency incidences in warm seasons (5 days moving average of temperature < 22 °C). However, the cumulative effects of total emergency incidences and Cvd emergency incidences were increased within the first lag 5 days, and then decreased until lag 21 in hot seasons (5 days moving average of temperature ≥ 22 °C). The cumulative effects of Res emergency incidences showed a declined trend from lag 0 to lag 21. The elderly (≥ 65, P1: RR = 1.49, 95% CI (1.30, 1.71); P99: RR = 0.86, 95% CI (0.71, 1.04)) and men (P1: RR = 1.27, 95% CI (1.14, 1.42)) seemed to be more vulnerable to extreme temperature than the younger (≤ 64, P1: RR = 1.19, 95% CI (1.08, 1.32); P99: RR = 1.00, 95% CI (0.89, 1.12)) and women (P1: RR = 1.17, 95%CI (1.06, 1.30)). The effects of extremely low temperature on all types of emergency incidences were stronger than those of extremely high temperature in the whole year. In addition, impacts of cold weather lasted about several days while those of hot weather were acute and rapid. An increased frequency of emergency incidences is predicted by rising temperatures variations. These results have clinical and public health implications for the management of emergency incidences.


Assuntos
Poluição do Ar/efeitos adversos , Serviço Hospitalar de Emergência/estatística & dados numéricos , Doença Aguda/epidemiologia , Adulto , Idoso , Poluentes Atmosféricos/análise , Poluição do Ar/estatística & dados numéricos , Doenças Cardiovasculares/epidemiologia , China/epidemiologia , Cidades , Temperatura Baixa , Calor Extremo/efeitos adversos , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Dinâmica não Linear , Risco , Estações do Ano
10.
Artigo em Inglês | MEDLINE | ID: mdl-30177663

RESUMO

BACKGROUND: China began to carry out fine particulate matter (PM2.5) monitoring in 2013 and the amount of related research is low, especially in areas with lighter air pollution. This study aims to explore the association between PM2.5 and cardiovascular disease (CVD), ischemic heart disease (IHD) and cerebral vascular disease (EVD) mortality in areas with lighter air pollution. METHODS: Data on resident mortality, air pollution and meteorology in Shenzhen during 2013⁻2015 were collected and analyzed using semi-parametric generalized additive models (GAM) with Poisson distribution of time series analysis. RESULTS: Six pollutants were measured at seven air quality monitoring sites, including PM2.5, PM10, SO2, NO2, CO and O3. The PM2.5 daily average concentration was 35.0 ± 21.9 µg/m³; the daily average concentration range was from 7.1 µg/m³ to 137.1 µg/m³. PM2.5 concentration had significant effects on CVD, IHD and EVD mortality. While PM2.5 concentration of lag5 and lag02 rose by 10 µg/m³, the excess risk (ER) of CVD mortality were 1.50% (95% CI: 0.51⁻2.50%) and 2.09% (95% CI: 0.79⁻3.41%), respectively. While PM2.5 concentration of lag2 and lag02 rose by 10 µg/m³, the ER of IHD mortality were 2.87% (95% CI: 0.71⁻5.07%) and 3.86% (95% CI: 1.17⁻6.63%), respectively. While PM2.5 concentration of lag4 and lag04 rose by 10 µg/m³, the ER of EVD mortality were 2.09% (95% CI: 2.28⁻3.92%) and 3.08% (95% CI: 0.68⁻5.53%), respectively. CONCLUSIONS: PM2.5 increased CVD mortality. The government needs to strengthen the governance of air pollution in areas with a slight pollution.


Assuntos
Poluentes Atmosféricos/análise , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/mortalidade , Exposição por Inalação/análise , Material Particulado/análise , Transtornos Cerebrovasculares/epidemiologia , Transtornos Cerebrovasculares/mortalidade , China/epidemiologia , Cidades , Humanos , Modelos Estatísticos , Isquemia Miocárdica/epidemiologia , Isquemia Miocárdica/mortalidade , Tamanho da Partícula
11.
Environ Sci Pollut Res Int ; 24(25): 20261-20272, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28702913

RESUMO

Although the growths of ambient pollutants have been attracting public concern, the characteristic of the associations between air pollutants and mortality remains elusive. Time series analysis with a generalized additive model was performed to estimate the associations between ambient air pollutants and mortality outcomes in Shenzhen City for the period of 2012-2014. The results showed that nitrogen dioxide (NO2)-induced excess risks (ER) of total non-accidental mortality and cardiovascular mortality were significantly increased (6.05% (95% CI 3.38%, 8.78%); 6.88% (95% CI 2.98%, 10.93%), respectively) in interquartile range (IQR) increase analysis. Also, these associations were strengthened after adjusting for other pollutants. Moreover, similar associations were estimated for sulfur dioxide (SO2), particulate matter with an aerodynamic diameter of <10 µm (PM10), and total non-accidental mortality. There were significant higher ERs of associations between PM10 and mortality for men than women; while there were significant higher ERs of associations between PM10/NO2 and mortality for elders (65 or elder) than youngers (64 or younger). Season analyses showed that associations between NO2 and total non-accidental mortality were more pronounced in hot seasons than in warm seasons. Taken together, NO2 was positively associated with total non-accidental mortality and cardiovascular mortality in Shenzhen even when the concentrations were below the ambient air quality standard. Policy measures should aim at reducing residents' exposure to anthropogenic NO2 emissions.


Assuntos
Poluentes Atmosféricos/toxicidade , Poluição do Ar/efeitos adversos , Monitoramento Ambiental , Mortalidade , Poluentes Atmosféricos/análise , Poluição do Ar/análise , China , Estudos Epidemiológicos , Feminino , Humanos , Masculino , Dióxido de Nitrogênio/análise , Dióxido de Nitrogênio/toxicidade , Material Particulado/análise , Material Particulado/toxicidade , Fatores de Risco , Dióxido de Enxofre/análise , Dióxido de Enxofre/toxicidade
12.
Neurosci Lett ; 656: 83-88, 2017 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-28735085

RESUMO

This study aimed to elucidate the protective effect of minocycline against streptomycin-induced damage of cochlear hair cells and its mechanism. Cochlear membranes were isolated from newborn Wistar rats and randomly divided into control, 500µmol/L streptomycin, 100µmol/L minocycline, and streptomycin and minocycline treatment groups. Hair cell survival was analyzed by detecting the expression of 3-nitrotyrosine (3-NT) in cochlear hair cells by immunofluorescence and an enzyme-linked immunosorbent assay. Expression of 3-NT and inducible nitric oxide synthase (iNOS), and poly (ADP-Ribose) polymerase (PARP) and caspase-3 activation were evaluated by western blotting. The results demonstrated hair cell loss at 24h after streptomycin treatment. No change was found in supporting cells of the cochleae. Minocycline pretreatment improved hair cell survival and significantly reduced the expression of iNOS and 3-NT in cochlear tissues compared with the streptomycin treatment group. PARP and caspase-3 activation was increased in the streptomycin treatment group compared with the control group, and pretreatment with minocycline decreased cleaved PARP and activated caspase-3 expression. Minocycline protected cochlear hair cells from injury caused by streptomycin in vitro. The mechanism underlying the protective effect may be associated with the inhibition of excessive formation of nitric oxide, reduction of the nitration stress reaction, and inhibition of PARP and caspase-3 activation in cochlear hair cells. Combined minocycline therapy can be applied to patients requiring streptomycin treatment.


Assuntos
Antibacterianos/toxicidade , Células Ciliadas Auditivas/efeitos dos fármacos , Minociclina/farmacologia , Fármacos Neuroprotetores/farmacologia , Óxido Nítrico/metabolismo , Poli(ADP-Ribose) Polimerases/metabolismo , Estreptomicina/toxicidade , Animais , Caspase 3/metabolismo , Morte Celular , Cóclea/efeitos dos fármacos , Cóclea/metabolismo , Cóclea/patologia , Ativação Enzimática , Células Ciliadas Auditivas/citologia , Óxido Nítrico Sintase Tipo II/metabolismo , Ratos Wistar , Transcrição Genética , Tirosina/análogos & derivados , Tirosina/metabolismo
13.
Front Psychol ; 7: 505, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27092100

RESUMO

Right hand responds faster than left hand when shown larger numbers and vice-versa when shown smaller numbers (the SNARC effect). Accumulating evidence suggests that the SNARC effect may not be exclusive for numbers and can be extended to other ordinal sequences (e.g., months or letters in the alphabet) as well. In this study, we tested the SNARC effect with a non-numerically ordered sequence: the Chinese notations for the color spectrum (Red, Orange, Yellow, Green, Blue, Indigo, and Violet). Chinese color word sequence reserves relatively weak ordinal information, because each element color in the sequence normally appears in non-sequential contexts, making it ideal to test the spatial organization of sequential information that was stored in the long-term memory. This study found a reliable SNARC-like effect for Chinese color words (deciding whether the presented color word was before or after the reference color word "green"), suggesting that, without access to any quantitative information or exposure to any previous training, ordinal representation can still activate a sense of space. The results support that weak ordinal information without quantitative magnitude encoded in the long-term memory can activate spatial representation in a comparison task.

14.
Wei Sheng Yan Jiu ; 44(2): 264-9, 2015 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-25997231

RESUMO

OBJECTIVE: To conduct a health risk assessment of pesticide residues and its annual trend analysis in drinking water in Shenzhen City. METHODS: The water quality monitoring data of product water, pipe water and secondary supply water during from 2011 to 2013 were collected and analyzed. The risk evaluation models recommended by the U. S. Environmental Protection Agency (USEPA) were employed to perform health risk assessments for children and adults on the 12 non-carcinogenic materials (namely, heptachlor, pentachlorophenol, hexachlorocyclohexane, hexachlorobenzene, DDT, malathion, glyphosate, dimethoate, bentazone, atrazine, chlorothalonil, furadan). Results The results of the analysis for water quality from 84 factory samples, 11 peripheral samples and one secondary supply water sample showed that all of the measured indicators in the above mentioned water samples met the National Health Standards (GB 5749-2006) published by Ministry of Health of the People's Republic of China. The adults and children' s health indices (HIs) of the 12 non-carcinogenic materials were greater than 1 (2. 323 - 6. 312). Dimethoate in factory and peripheral water samples posed the largest risks of harm among the non-carcinogenic pollutants measured. And its HIi were also greater than 1 (1. 995 - 5. 094) and followed by hexachlorobenzene and heptachlor. Annual rising trend on health risk of the 12 pesticide residues indicated that their HIT on adults was 2323. 18 x 10(-3) in 2011, 2340. 18 x 10(-3) in 2012 and 2431. 97 x 10(-3) in 2013, and on children 2965. 07 x 10 (-3) in 2011, 2986. 77 x 10(-3) in 2012 and 3103. 93 x 10(-3) in 2013, respectively. This study also suggested that the average risk of peripheral water samples (HIT was equal to 2619. 64 x 10(-3) was greater than that of factory samples (HIT was same as 2366. 92 x 10(-3), and more children' s health risk than adults' risk. CONCLUSION: Health risks of pesticide residues in drinking water in Shenzhen have exceeded the threshold value and dimethoate was the main hazard and more children's health risk than adults' risk. Furthermore, there was an annual rising slowly trend on health risks of pesticide residues in drinking water.


Assuntos
Água Potável/análise , Resíduos de Praguicidas/análise , Poluentes Químicos da Água , Abastecimento de Água/normas , Adulto , Atrazina , Criança , China , Monitoramento Ambiental , Substâncias Perigosas , Humanos , Medição de Risco
15.
Forsch Komplementmed ; 22(2): 94-100, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26021959

RESUMO

BACKGROUND: Whether subgroups of functional dyspepsia (FD) should be treated with different approaches is controversially discussed in research. As our previous study has demonstrated the effect of acupuncture in FD treatment, we now further analyze the therapeutic effect of acupuncture in the treatment of postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). METHODS: A retrospective analysis was conducted in 465 eligible PDS patients and 241 EPS patients. 4 acupuncture groups (group A: specific acupoints along the stomach meridian; group B: non-specific acupoints along the stomach meridian; group C: alarm and transport acupoints; group D: specific acupoints along the gallbladder meridian) were compared with a non-acupoint sham acupuncture group and an itopride group. The patients were treated in 5 consecutive sessions per week for 4 weeks and were followed-up for 12 weeks afterwards. Primary outcome of the study was defined as response rate and symptom improvement as measured by the Symptom Index of Dyspepsia, while secondary outcome was designated as improvement in quality of life (QoL) as determined by the Nepean Dyspepsia Index. RESULTS: Symptoms of dyspepsia and QoL were improved from baseline in all groups. In EPS patients, no statistically significant differences could be observed in response rate (p = 0.239) and symptoms improvement (p = 0.344 for epigastric pain; p = 0.465 for epigastric burning). In contrast, PDS patients of the acupuncture group A showed higher response rate (53.2% vs. 19.7%, p<0.001; 53.2% vs. 35.1%, p = 0.025) and score change in postprandial fullness (1.01 vs. 0.27, p<0.001; 1.01 vs. 0.57, p<0.001), early satiation (0.81 vs. 0.21, p<0.001; 0.81 vs. 0.39, p=0.001), and QoL (14.5 vs. 4.33, p<0.001; 14.5 vs. 8.5, p<0.001) compared to the sham acupuncture and itopride group. CONCLUSIONS: FD patients with PDS responded better to the acupuncture therapies, especially at the specific acupoints along the stomach meridian. The positive therapeutic effect of acupuncture on PDS was correlated with the improvement in postprandial fullness. TRIAL REGISTRATION: ClinicalTrial.gov NCT00599677.


Assuntos
Terapia por Acupuntura/normas , Dispepsia/terapia , Dispepsia/classificação , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Estudos Retrospectivos , Resultado do Tratamento
16.
Australas J Ageing ; 33(4): 278-82, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24112825

RESUMO

AIM: The purpose of this study was to explore the effects of three commonly used positions on grip strength measurement in older people. METHOD: A total of 249 (113 women, 136 men) older participants, 72.8 ± 6.5 years old, participated in this study. Grip strength (kg) was measured in three positions: (i) the standard posture (sitting, elbow flexed 90°) suggested by the American Society of Hand Therapists; (ii) standing, elbow flexed 90°; and (3) standing, elbow fully extended. RESULTS: One-way repeated measures analysis of variance showed that grip strength was significantly greater in the standing position with the elbow fully extended than in the other two positions. CONCLUSIONS: The grip strengths obtained from the three positions were not all comparable in our community-dwelling older adults. Clinicians and researchers need to be cautious when choosing testing position for assessing and interpreting grip strength results obtained from these positions.


Assuntos
Envelhecimento , Avaliação Geriátrica/métodos , Força da Mão , Posicionamento do Paciente , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Feminino , Humanos , Masculino , Postura , Valor Preditivo dos Testes , Reprodutibilidade dos Testes , Taiwan
17.
Artigo em Chinês | MEDLINE | ID: mdl-21924098

RESUMO

OBJECTIVE: To explored the significance of screening the gene mutations of deafness related in deaf-mute (deaf & dumb) family using DNA microarray. METHODS: Total of 52 couples of deaf-mute were recruited from Changchun deaf-mute community. With an average age of (58.3 ± 6.7) years old (x(-) ± s). Blood samples were obtained with informed consent. Their genomic DNA was extracted from peripheral blood and PCR was performed. Nine of hot spot mutations in four most common deafness pathologic gene were examined with the DNA microarray, including GJB2, GJB3, PDS and mtDNA 12S rRNA genes. At the same time, the results were verified with the traditional methods of sequencing. Fifty of normal people served as a control group. RESULTS: All patients were diagnosed non-syndromic sensorineural hearing loss by subjective pure tone audiometry. Thirty-two of 104 cases appeared GJB2 gene mutation (30.7%), the mutation sites included 35delG, 176del16, 235delC and 299delAT. Eighteen of 32 cases of GJB2 mutations were 235delC (59.1%). Seven of 104 cases appeared SLC26A4 gene IVS7-2 A > G mutation. Questionnaire survey and gene diagnosis revealed that four of 52 families have deaf offspring (7.6%). When a couple carries the same gene mutation, the risk of their children deafness was 100%. The results were confirmed with the traditional methods of sequencing. CONCLUSIONS: There is a high risk of deafness if a deaf-mute family is planning to have a new baby. It is very important and helpful to avoid deaf newborns again in deaf-mute family by DNA microarray.


Assuntos
Surdez/genética , Surdez/prevenção & controle , Testes Genéticos/métodos , Análise de Sequência com Séries de Oligonucleotídeos , Estudos de Casos e Controles , Conexinas , Análise Mutacional de DNA , Surdez/diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
18.
Wei Sheng Yan Jiu ; 40(4): 485-8, 2011 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-21861355

RESUMO

OBJECTIVE: To explore quantitatively the impact of the ambient air PM10 concentration (inhalable particulate matter) on the hospital outpatients for respiratory diseases. METHODS: Daily hospital visits data in 2008 was collected from a hospital in Shenzhen, meteorological data and air pollution data were collected from Shenzhen Meteorological Bureau and Shenzhen Environmental Protection Bureau, respectively. There was a time serial analysis using semi-parameter generalized additive model extend Poisson regression, after controlled with long-term tend, the-day-of-week, meteorological factors and other air pollutants. Excess relative risks (ER) of daily hospital visits associated with increased PM10 level were estimated. RESULTS: Ambient air PM10 concentration were no association with the increase of outpatients for respiratory in the same day. The lagged effect of 5 days with an ER of 1.113% (95% CI 0.613% - 1.616%) was observed. Except (PM10 + CO) model, the ER value increased when SO2, NO2, CO concentrations were introduced. CONCLUSION: The ambient air PM10 concentration could positively associated with the increase of daily hospital visits for respiratory diseases in Shenzhen.


Assuntos
Poluição do Ar/efeitos adversos , Assistência Ambulatorial/estatística & dados numéricos , Exposição Ambiental/efeitos adversos , Material Particulado/efeitos adversos , Poluição do Ar/estatística & dados numéricos , Bronquite/epidemiologia , Bronquite/etiologia , Monóxido de Carbono/análise , China/epidemiologia , Exposição Ambiental/análise , Humanos , Dióxido de Nitrogênio/análise , Material Particulado/análise , Pneumonia/epidemiologia , Pneumonia/etiologia , Dióxido de Enxofre/análise
19.
Artigo em Chinês | MEDLINE | ID: mdl-21563464

RESUMO

OBJECTIVE: To determine the possible gene mutation and its different sites that leads to hearing loss in a consanguineous marriage pedigree. METHOD: Blood samples from a Changchun pedigree were obtained with informed consent. Their genomic DNA were extracted from peripheral blood and PCR was performed. Nine of hot spot mutations in four most common deafness pathologic gene were detected with the DNA microarray, including GJB2, GJB3, PDS and mtDNA 12S RNA gene. At the same time, the results were confirmed with the traditional methods of sequencing. RESULT: GJB2 gene of 235 delC and 299-300 delAT compound heterozygous mutation was found in propositus. His father was 299-300 delAT homozygous mutation and mother was 235 delC homozygous mutation. In the relatives on the paternal side, the affected patients all were 299-300 delAT homozygous mutation and normal hearing member was 299-300 delAT heterozygous carrier. This GJB2 mutation come from grandparents of consanguineous marriage. CONCLUSION: GJB2 gene mutation played on an important role in this deafness family. It is essential approach for genetic diagnosis of non - syndromic sensorineural hearing loss.


Assuntos
Surdez/genética , Análise de Sequência com Séries de Oligonucleotídeos/métodos , Conexina 26 , Conexinas/genética , Consanguinidade , Surdez/etiologia , Feminino , Heterozigoto , Humanos , Masculino , Linhagem , Adulto Jovem
20.
Wei Sheng Yan Jiu ; 39(4): 459-61, 2010 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-20726238

RESUMO

OBJECTIVE: To explore the changes of lung function of primary students living in the regions of different air pollution. METHODS: Nanshan District and Longgang District were decided respectively as a relatively heavy air pollution region and as a relatively light air pollution region in Shenzhen according to their air pollutant concentrations. The daily monitoring values on atmospheric SO2, NO2, PM10 and CO from 2006 to 2008 in the two districts were collected. PM2.5 monthly monitoring was started in Jan. 2008. Pulmonary functions of primary students were performed in the two schools within the scope of the surrounding 3km of the PM2.5 monitoring points. RESULTS: Average concentrations of atmospheric SO2, NO2, CO, PM10 and PM2.5 in Nanshan District were more high than those in Longgang District. Their concentrations were 0.0285 mg/m3 vs 0.0227 mg/m3, 0.0649 mg/m3 vs 0.0473 mg/m3, 2.278 mg/m3 vs 1.478 mg/m3, 0.0724 mg/m3 vs 0.0713 mg/m3 and 0.0665 mg/m3 vs 0.0524 mg/m3 (P < 0.05) respectively except PM10. Levels of the key indicators of lung function (VC, VC%, FVC, FVC%, MVV, MVV%, FEV1.0, FEV1.0/FVC, PEF, PEF%, FEF25, FEF50 and FEF75) increased with ages in the primary students. Means of the most indicators in Nanshan District were higher than those in primary students in Longgang District. Significant difference existed in the same grade of students on lung function in the two regions (P < 0.05). CONCLUSION: Air pollution could affect pulmonary function of primary students.


Assuntos
Poluição do Ar/efeitos adversos , Pulmão/fisiologia , Material Particulado/efeitos adversos , Poluentes Atmosféricos/análise , Poluição do Ar/análise , Criança , China , Feminino , Humanos , Masculino , Dióxido de Nitrogênio/análise , Material Particulado/análise , Testes de Função Respiratória , Instituições Acadêmicas , Estudantes , Dióxido de Enxofre/análise
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