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1.
Chemosphere ; 287(Pt 3): 132305, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34563770

RESUMO

BACKGROUND: Metal exposures are suspected to associate with the risk of hyperuricemia (HUA), but the current results are still conflicting. OBJECTIVE: To investigate the associations between multiple plasma metal exposures and HUA risk. METHODS: A cross-sectional study was conducted in 1406 Chinese Han adults who underwent routine physical examination in the Eighth Affiliated Hospital of Sun Yat-Sen University in Shenzhen. The plasma levels of 13 metals were measured by the inductively coupled plasma mass spectrometry (ICP-MS). Multivariable logistic, linear regression models, least absolute shrinkage and selection operator (LASSO) penalized regression analysis, and restricted cubic spline (RCS) models were applied to assess the associations. RESULTS: The median plasma uric acid concentration in HUA group (434 µmol/L) was significantly higher than that in non-HUA group (305 µmol/L). The multivariate-adjusted odds ratios (95% confidence intervals) of HUA were 1.62(1.08-2.43) for magnesium, 1.61(1.05-2.47) for copper, 1.62(1.06-2.49) for zinc, 1.87(1.26-2.81) for arsenic, 1.50(1.01-2.23) for selenium, and 1.70(1.16-2.49) for thallium based on the single-metal logistic regression models, comparing the highest versus the lowest quartile of metal levels. Further multi-metal logistic, linear regression models and the LASSO analysis all indicated positive associations of zinc, arsenic with HUA risk or uric acid levels. RCS model indicated an inverted V-shaped positive association between zinc levels and HUA risk (p for non-linearity = 0.048, p for overall association = 0.022), while arsenic levels showed a positive and linear dose-response relationship with HUA risk (p for non-linearity = 0.892, p for overall association<0.001). CONCLUSIONS: Higher plasma levels of zinc and arsenic might increase HUA risk and showed positive dose-response relationships. Further cohort studies in larger population are required to testify our findings.


Assuntos
Hiperuricemia , Adulto , China/epidemiologia , Estudos Transversais , Humanos , Hiperuricemia/epidemiologia , Metais , Pessoa de Meia-Idade , Ácido Úrico
2.
Int J Public Health ; 66: 1604235, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34483811

RESUMO

Objectives: This study aimed to investigate the associations between air pollution exposure and pediatric outpatient visits for dry eye disease (DED) in Shenzhen, China. Methods: Generalized additive models were utilized to explore the acute effects of air pollution exposure on pediatric outpatient visits for DED. Results: Single-day lag exposures to NO2, O3, PM2.5, and PM10 were associated with DED outpatient visits at lag days 0, 6, 4 and 2. Relative risks (RRs) for DED given a 10-µg/m3 increase in NO2, O3, PM2.5, and PM10 concentrations were 1.062[95% confidence interval (CI) 1.003, 1.123], 1.015(95% CI 1.001, 1.031), 1.052(95% CI 1.001, 1.115), and 1.038 (95% CI 1.002, 1.076), respectively. RR for DED given a 10-µg/m3 increase in NO2 over cumulative lag days 0-1 was 1.075 (95% CI 1.009, 1.147), and RR for DED given a 10-µg/m3 increase in PM10 over cumulative lag days 0-4 was 1.051 (95% CI 1.003, 1.102). Conclusion: The observed associations between air pollution and outpatient visits for DED may provide evidence for policy makers to consider implementing measures to reduce the risk of DED owing to air pollution in China.


Assuntos
Poluição do Ar , Assistência Ambulatorial , Síndromes do Olho Seco , Exposição Ambiental , Poluição do Ar/efeitos adversos , Assistência Ambulatorial/estatística & dados numéricos , Criança , China/epidemiologia , Síndromes do Olho Seco/epidemiologia , Síndromes do Olho Seco/terapia , Exposição Ambiental/efeitos adversos , Exposição Ambiental/estatística & dados numéricos , Humanos
3.
Artigo em Inglês | MEDLINE | ID: mdl-34444520

RESUMO

Temperature change is an important meteorological indicator reflecting weather stability. This study aimed to examine the effects of ambient temperature change on non-accidental mortality using diurnal temperature change (DTR) and temperature change between neighboring days (TCN) from two perspectives, intra-day and inter-day temperature change, and further, to explore seasonal variations of mortality, identify the susceptible population and investigate the interaction between temperature change and apparent temperature (AT). We collected daily data on cause-specific mortality, air pollutants and meteorological indicators in Shenzhen, China, from 1 January 2013 to 29 December 2017. A Quasi-Poisson generalized linear regression combined with distributed lag non-linear models (DLNMs) were conducted to estimate the effects of season on temperature change-related mortality. In addition, a non-parametric bivariate response surface model was used to explore the interaction between temperature change and AT. The cumulative effect of DTR was a U-shaped curve for non-accidental mortality, whereas the curve for TCN was nearly monotonic. The overall relative risks (RRs) of non-accidental, cardiovascular and respiratory mortality were 1.407 (95% CI: 1.233-1.606), 1.470 (95% CI: 1.220-1.771) and 1.741 (95% CI: 1.157-2.620) from exposure to extreme large DTR (99th) in cold seasons. However, no statistically significant effects were observed in warm seasons. As for TCN, the effects were higher in cold seasons than warm seasons, with the largest RR of 1.611 (95% CI: 1.384-1.876). The elderly and females were more sensitive, and low apparent temperature had a higher effect on temperature change-related non-accidental mortality. Temperature change was positively correlated with an increased risk of non-accidental mortality in Shenzhen. Both female and elderly people are more vulnerable to the potential adverse effects, especially in cold seasons. Low AT may enhance the effects of temperature change.


Assuntos
Poluentes Atmosféricos , Idoso , Poluentes Atmosféricos/análise , China/epidemiologia , Temperatura Baixa , Feminino , Temperatura Alta , Humanos , Mortalidade , Estações do Ano , Temperatura
4.
Materials (Basel) ; 14(13)2021 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-34203401

RESUMO

The influences of non-isothermal aging (the temperature range is 150-180 °C, and the heating rate is 5 and 20 °C/h alternately), single-peak aging (aging at 120 °C for 24 h, then water quenched was followed at room temperature), and two-stage aging (aging at 105 °C for 8 h first, then increasing aging temperature to 135 °C and keeping for 12 h, followed by water quenching at room temperature) on the corrosion resistance and microstructure of the 7N01 aluminum alloy under 3.5 wt.% NaCl were investigated using electric polarization curve test and exfoliation corrosion. After aging, the hardness of samples was measured by a Vickers micro-hardness tester, and the electrical conductivities were obtained using the eddy current method. The results show that the steady phase η and metastable phase η' are precipitated in the grain boundary of 7N01 aluminum alloy after non-isothermal aging, and their distribution is discontinuous. The hardness of the alloy can reach 136.9 HV1 and the electrical conductivity can reach 35.8% IACS, which is close to the hardness of single-peak aging and the conductivity of two-stage aging, respectively. Compared with single-peak aging, the corrosion current density of non-isothermal aging is reduced by 15.5%, and that of two-stage aging is reduced by 28.9%.

5.
Materials (Basel) ; 14(10)2021 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-34068956

RESUMO

Electrochemical corrosion behavior of ternary tin-zinc-yttrium (Sn-9Zn-xY) solder alloys were investigated in aerated 3.5 wt.% NaCl solution using potentiodynamic polarization techniques, and the microstructure evolution was obtained by scanning electron microscope (SEM). Eight different compositions of Sn-9Zn-xY (x = 0, 0.02, 0.04, 0.06, 0.08, 0.10, 0.20, and 0.30 wt.%) were compared by melting. The experimental results show that when the content of Y reached 0.06 wt.%, the grain size of Zn-rich phase became the smallest and the effect of grain refinement was the best, but there was no significant effect on the melting point. With the increases of Y content, the spreading ratio first increased and then decreased. When the content of Y was 0.06 wt.%, the Sn-9Zn-0.06Y solder alloy had the best wettability on the Cu substrate, which was increased by approximately 20% compared with Sn-9Zn. Besides, the electrochemical corrosion experimental shows that the Y can improve the corrosion resistance of Sn-9Zn system in 3.5 wt.% NaCl solution, and the corrosion resistance of the alloy is better when the amount of Y added is larger within 0.02-0.30 wt.%. Overall considering all performances, the optimal performance can be obtained when the addition amount of Y is 0.06.

6.
PLoS One ; 15(2): e0229130, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32092079

RESUMO

Human adults are faster to respond to small/large numerals with their left/right hand when they judge the parity of numerals, which is known as the SNARC (spatial-numerical association of response codes) effect. It has been proposed that the size of the SNARC effect depends on response latencies. The current study introduced a perceptual orientation task, where participants were asked to judge the orientation of a digit or a frame surrounding the digit. The present study first confirmed the SNARC effect with native Chinese speakers (Experiment 1) using a parity task, and then examined whether the emergence and size of the SNARC effect depended on the response latencies (Experiments 2, 3, and 4) using a perceptual orientation judgment task. Our results suggested that (a) the automatic processing of response-related numerical-spatial information occurred with Chinese-speaking participants in the parity task; (b) the SNARC effect was also found when the task did not require semantic access; and (c) the size of the effect depended on the processing speed of the task-relevant dimension. Finally, we proposed an underlying mechanism to explain the SNARC effect in the perceptual orientation judgment task.


Assuntos
Julgamento/fisiologia , Tempo de Reação/fisiologia , Percepção Espacial/fisiologia , Processamento Espacial/fisiologia , Feminino , Humanos , Masculino , Matemática , Adulto Jovem
7.
PLoS One ; 15(1): e0227408, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31940393

RESUMO

Pepsin plays an important role in laryngopharyngeal reflux (LPR), a risk factor for the development of hypopharyngeal squamous cell carcinomas (HPSCC). However, the role of pepsin in HPSCC is not clear. We show by immunohistochemistry that pepsin positivity occurs in a significant proportion of human primary HPSCC specimens, and in many cases matched adjacent uninvolved epithelia are negative for pepsin. Pepsin positivity is associated with nodal involvement, suggesting that pepsin may have a role in metastasis. Treatment of FaDu cancer cells with pepsin increased cell proliferation, possibly by inducing G1/S transition. We also observed significant changes in expression of genes involved in NF-kappaB, TRAIL and Notch signaling. Our data suggest that pepsin plays an important role in HPSCC and that targeting pepsin could have potential therapeutic benefits.


Assuntos
Carcinoma de Células Escamosas/metabolismo , Fase G1 , Regulação Neoplásica da Expressão Gênica , Neoplasias Laríngeas/metabolismo , Proteínas de Neoplasias/metabolismo , Pepsina A/metabolismo , Neoplasias Faríngeas/metabolismo , Fase S , Transdução de Sinais , Idoso , Carcinoma de Células Escamosas/patologia , Linhagem Celular Tumoral , Feminino , Humanos , Neoplasias Laríngeas/patologia , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Pepsina A/farmacologia , Neoplasias Faríngeas/patologia
8.
Chemosphere ; 244: 125498, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31812049

RESUMO

BACKGROUND: Heavy metal exposure induces oxidative stress, which is critical for adverse male reproductive health. OBJECTIVE: To explore the mediating effect of oxidative stress on the relationship of heavy metal exposure with semen quality. METHODS: Urinary levels of three oxidative stress markers, semen quality, and urinary arsenic, cadmium and lead were examined among 1020 men. Multivariate linear regression was applied to explore cross-sectional associations, and the role of oxidative stress as mediators was investigated. RESULTS: Quartiles of metals showed significant dose-dependent relationships with increasing levels of 8-hydroxy-2deoxyguanosine (8-OHdG), 8-iso-prostaglandin F2α (8-isoPGF2α) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA). Significant or suggestive associations were also found between urinary 8-OHdG levels and the percentage of normal sperm morphology (ptrend < 0.001), between urinary 8-isoPGF2α levels and total motility (ptrend = 0.052), progressive motility (ptrend = 0.050) respectively. The mediation analysis showed that about 14.59%, 18.06%, 15.35% or 16.49% of the association between arsenic/cadmium exposure and the decreased total motility/progressive motility was mediated by 8-isoPGF2α, respectively. In addition, about 16.47% of the relationship between lead exposure and the decreased percentage of normal sperm morphology was mediated by 8-OHdG. CONCLUSIONS: Our findings suggest that higher urinary arsenic, cadmium and lead levels were associated with increased oxidative stress markers, which also related with altered semen quality. 8-isoPGF2α and 8-OHdG might be the possible mediators of the associations between urinary heavy metals and total motility, progressive motility or the proportion of normal sperm morphology.


Assuntos
Exposição Ambiental/análise , Poluentes Ambientais/toxicidade , Metais Pesados/toxicidade , Sêmen/efeitos dos fármacos , 8-Hidroxi-2'-Desoxiguanosina , Adulto , Biomarcadores/urina , Cádmio , Estudos Transversais , Humanos , Chumbo/toxicidade , Masculino , Estresse Oxidativo , Reprodução , Análise do Sêmen
9.
Materials (Basel) ; 12(22)2019 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-31726701

RESUMO

Sn-0.7Cu-0.075Al solder alloy adding with Ce and La had been successfully prepared by applying ball-milling and vacuum arc remelting. The influence of Ce and La on microstructure and corrosion behavior of Sn-0.7Cu-0.075Al solder alloy was investigated. The results showed that Ce (La)-containing solders had refined grains and obvious directional tendency due to the dispersive refiner (CeO2 and La2O3). Electrochemical potentiodynamic curves revealed three different stages of the reaction, including anodic and cathodic processes, prepassivation section, and stable passivation stages. The self-corrosion potential (Ecorr) of alloys with Ce and La addition were a little bit more negative, hardly making a difference on corrosion occurrence. However, the corrosion current density (Icorr) and passivation current density (Ip) decreased by two-thirds and one-half respectively, which indicated a better corrosion resistant after adding rare earths. The recorded micrographs of corroded surface at different polarized points witnessed the formation of corrosion product film both on prepassivation and passivation stage. Moreover, the cross section of corrosion product film showed the coarse, loose film in Sn-0.7Cu-0.075Al solder and adherent, compact film in Ce (La)-containing solders, which further indicated an excellent anti-corrosion property.

10.
Sci Total Environ ; 697: 134051, 2019 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-31487586

RESUMO

BACKGROUND: The intricate association of mortality risk with ambient air pollution and temperature is of growing concern. Little is known regarding effect of changes in season and temperature on daily cardiovascular mortality associated with air pollutant nitrogen dioxide (NO2). OBJECTIVES: Our study aimed to assess the effect of NO2 on cardiovascular mortality modified by season and daily air temperature in the effect, and further to identify the population highly susceptible to cardiovascular mortality associated with NO2 and air temperature. METHODS: We collected daily cause-specific death data, weather conditions, and air pollutant concentrations in Shenzhen from 2013 to 2017. Distributed-lag linear models were employed to analyze the effect of season on the NO2-associated mortality. Furthermore, generalized additive models were combined with stratification parametric analysis to estimate the interaction effect of NO2 with air temperature on cardiovascular mortality. RESULTS: In the cold season, the percentage increase in daily mortality for every 10 µg/m3 increment in NO2 concentration over lags of 0-2 days was 4.45% (95% CI: 2.71-6.21%). However, no statistically significant effect of NO2 was observed in the warm season. Compared with high-temperature days (>median temperature), a 3.51% increase in mortality (95% CI: 2.04-5.01%) over low-temperature days (≤median temperature) for the same increase in NO2 was significant. Air temperature modified the effect of NO2 on daily mortality by 4.08% (95% CI: 2.28-5.91%) for the elderly (age ≥ 65 years) on low-temperature days vs. -0.82% (95% CI: -3.88-2.34%) on high-temperature days, and 3.38% (95% CI: 1.50-5.29%) for males on low-temperature days vs. -0.73% (95% CI: -3.83-2.47%) on high air temperature days. CONCLUSIONS: The cold season and low temperatures could significantly enhance the effect of NO2 on cardiovascular mortality. The elderly and males suffering from cardiovascular disease should take precautions against low temperature and NO2 air pollution.


Assuntos
Poluentes Atmosféricos/análise , Poluição do Ar/estatística & dados numéricos , Doenças Cardiovasculares/mortalidade , Exposição Ambiental/estatística & dados numéricos , Dióxido de Nitrogênio/análise , Temperatura , Idoso , Causas de Morte , China/epidemiologia , Feminino , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Tempo (Meteorologia)
11.
Mol Med Rep ; 20(3): 2609-2616, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31322239

RESUMO

The aim of the present study was to elucidate the role of the non­syndromic autosomal recessive deafness 12 allelic variant of cadherin 23 (CDH23) in Chinese patients with non­syndromic hearing loss. The present study focused on a Chinese family with hearing loss in which there were two siblings with autosomal, recessive deafness, ranging from severe to profound hearing loss over all frequencies. DNA sequencing was used to assess the genetic factors in the disease etiology. The data revealed a compound heterozygous mutation of CDH23 in both patients. Genetic CDH23 variants are known to be responsible for non­syndromic hearing loss, and CDH23 variants frequently occur in various populations, including Japanese and Republic of Korean. Results from the present study, indicated a significant contribution of CDH23 variants to the non­syndromic hearing loss in Chinese patients.


Assuntos
Caderinas/genética , Perda Auditiva Neurossensorial/genética , Adolescente , Sequência de Aminoácidos , Grupo com Ancestrais do Continente Asiático/genética , Caderinas/química , Feminino , Perda Auditiva/genética , Heterozigoto , Humanos , Masculino , Modelos Moleculares , Mutação , Linhagem , Alinhamento de Sequência , Irmãos , Adulto Jovem
12.
Artigo em Inglês | MEDLINE | ID: mdl-30708969

RESUMO

Background: China is at its most important stage of air pollution control. Research on the association between air pollutants and human health is very important and necessary. The purpose of this study was to evaluate the association between PM2.5 concentrations and residents' mortality and to compare the effect of PM2.5 on the different diseases, accidental deaths, sex or age of residents from high polluted areas with less polluted areas. Methods: The semi-parametric generalized additive model (GAM) with Poisson distribution of time series analysis was used. The excess risk (ER) of mortality with the incremental increase of 10 µg/m³ in PM2.5 concentration was calculated. Concentration-response relationship curves and autocorrelation between different lags of PM2.5 were also evaluated. Results: PM2.5 exposure was significantly associated with the mortality of residents. The strongest ERs per 10 µg/m³ increase in PM2.5 were 0.74% (95% CI: 0.11⁻1.38%) for all-cause, 0.67% (95% CI: 0.01⁻1.33%) for non-accidental, 1.81% (95% CI: 0.22⁻3.42%) for accidental, 3.04% (95% CI: 0.60⁻5.55%) for total respiratory disease, 6.38% (95% CI: 2.78⁻10.11%) for chronic lower respiratory disease (CLRD), 8.24% (95% CI: 3.53⁻13.17%) for chronic obstructive pulmonary disease (COPD), 1.04% (95% CI: 0.25⁻1.84%) for male and 1.32% (95% CI: 0.46⁻2.19%) for elderly. Furthermore, important information on the concentration-response relationship curves was provided. Conclusions: PM2.5 can increase the risk of residents' mortality, even in places with less air pollution and developed economy in China.


Assuntos
Poluentes Atmosféricos/toxicidade , Exposição por Inalação/efeitos adversos , Exposição por Inalação/estatística & dados numéricos , Mortalidade , Material Particulado/toxicidade , Poluentes Atmosféricos/química , China , Cidades , Relação Dose-Resposta a Droga , Humanos , Tamanho da Partícula , Material Particulado/química , Distribuição de Poisson
13.
Water Sci Technol ; 80(9): 1683-1691, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32039900

RESUMO

The pollution from nuclear leaks and nuclear disasters (e.g. radioactive iodine) would cause serious harm to human beings and ecosystems for many years. Cocoon silk and deep eutectic solvents (DESs) are both green substances. DESs are easily synthesized, cheap, highly biocompatible and highly biodegradable. Here, we combine the removal of organic dyes and the capture of radioactive iodine by using green DES-pretreated cocoon silk. It is the first time organic dyes have been removed from wastewater by DES-disrupted silk for the purpose of favourably removing iodine. Organic dyes-captured DES-pretreated cocoon silk could be used to capture iodine efficiently. It opens a new route to dispose of one waste from nuclear energy with organic dyes from wastewater captured by green solvents-pretreated natural silk.


Assuntos
Neoplasias da Glândula Tireoide , Águas Residuárias , Ecossistema , Humanos , Radioisótopos do Iodo , Seda , Solventes
14.
J Gen Psychol ; 145(4): 415-430, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30457038

RESUMO

Many previous studies have demonstrated the SNARC effect-i.e., participants are faster to respond with their left/right hand to small/large numbers. However, there is a debate on whether it is based on working or long-term memory (i.e., relative or absolute magnitude). Here, we examined the flexibility of the spatial-numerical associations using orientation judgment tasks. Participants were asked to judge the orientation of a rotated frame surrounding an Arabic digit under numerical ranges 1-6, 4-9 (Experiment 1), and 1-9 (Experiment 2). The task difficulty was manipulated by rotating stimuli. We observed a significant SNARC effect for range 1-6 and a reversed SNARC effect for 4-9, regardless of the total numerical range presented in the task. Furthermore, the SNARC effect became more salient with increasing task difficulty. Our results suggest that the SNARC effect is based on the absolute magnitude of digits, supporting the long-term memory explanation.


Assuntos
Cognição/fisiologia , Julgamento/fisiologia , Percepção Espacial/fisiologia , Feminino , Humanos , Masculino , Matemática , Testes Neuropsicológicos , Tempo de Reação/fisiologia , Adulto Jovem
15.
Environ Sci Pollut Res Int ; 25(36): 36239-36255, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30367425

RESUMO

Extreme temperature has been reported to be associated with an increase in acute disease incidence in several cities. However, few similar studies were carried out in Shenzhen, which is a subtropical city located in the southern China. This study explored the relationship between the emergency incidences and extreme temperatures, and investigated the role of air pollutants played in the temperature-related effects on human health in Shenzhen. We conducted a distributed lag nonlinear model study on the effect of extreme temperatures on emergency incidences in Shenzhen city during 2013-2017. Here, only the total emergency incidences, emergency incidences for respiratory diseases, and cardiovascular diseases were taken into consideration. Air pollution, subgroups, and seasons were adjusted to investigate the impacts of extreme temperatures on emergency incidences. Relative risk (RR) and 95% confidence intervals were calculated with the R software. From lag 0 to 21 days, the RR of temperature-total emergency department visits, temperature-cardiovascular, and temperature-respiratory diseases was 1.09 (95% CI: 0.98-1.20), 1.22 (95% CI: 0.96-1.56), and 1.06 (95% CI: 0.70-1.60) at extremely low temperature (first percent of temperature, 10 °C), respectively. During the same lag days, the RR was 1.02 (95 % CI: 0.92-1.14), 0.64 (95% CI: 0.49-0.86), and 0.92 (95% CI: 0.56-1.53) between extremely high temperature and total emergency department visits, cardiovascular, and respiratory diseases, respectively. The cumulative effects gradually went up with time for all types of emergency incidences in warm seasons (5 days moving average of temperature < 22 °C). However, the cumulative effects of total emergency incidences and Cvd emergency incidences were increased within the first lag 5 days, and then decreased until lag 21 in hot seasons (5 days moving average of temperature ≥ 22 °C). The cumulative effects of Res emergency incidences showed a declined trend from lag 0 to lag 21. The elderly (≥ 65, P1: RR = 1.49, 95% CI (1.30, 1.71); P99: RR = 0.86, 95% CI (0.71, 1.04)) and men (P1: RR = 1.27, 95% CI (1.14, 1.42)) seemed to be more vulnerable to extreme temperature than the younger (≤ 64, P1: RR = 1.19, 95% CI (1.08, 1.32); P99: RR = 1.00, 95% CI (0.89, 1.12)) and women (P1: RR = 1.17, 95%CI (1.06, 1.30)). The effects of extremely low temperature on all types of emergency incidences were stronger than those of extremely high temperature in the whole year. In addition, impacts of cold weather lasted about several days while those of hot weather were acute and rapid. An increased frequency of emergency incidences is predicted by rising temperatures variations. These results have clinical and public health implications for the management of emergency incidences.


Assuntos
Poluição do Ar/efeitos adversos , Serviço Hospitalar de Emergência/estatística & dados numéricos , Doença Aguda/epidemiologia , Adulto , Idoso , Poluentes Atmosféricos/análise , Poluição do Ar/estatística & dados numéricos , Doenças Cardiovasculares/epidemiologia , China/epidemiologia , Cidades , Temperatura Baixa , Calor Extremo/efeitos adversos , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Dinâmica não Linear , Risco , Estações do Ano
16.
Artigo em Inglês | MEDLINE | ID: mdl-30177663

RESUMO

BACKGROUND: China began to carry out fine particulate matter (PM2.5) monitoring in 2013 and the amount of related research is low, especially in areas with lighter air pollution. This study aims to explore the association between PM2.5 and cardiovascular disease (CVD), ischemic heart disease (IHD) and cerebral vascular disease (EVD) mortality in areas with lighter air pollution. METHODS: Data on resident mortality, air pollution and meteorology in Shenzhen during 2013⁻2015 were collected and analyzed using semi-parametric generalized additive models (GAM) with Poisson distribution of time series analysis. RESULTS: Six pollutants were measured at seven air quality monitoring sites, including PM2.5, PM10, SO2, NO2, CO and O3. The PM2.5 daily average concentration was 35.0 ± 21.9 µg/m³; the daily average concentration range was from 7.1 µg/m³ to 137.1 µg/m³. PM2.5 concentration had significant effects on CVD, IHD and EVD mortality. While PM2.5 concentration of lag5 and lag02 rose by 10 µg/m³, the excess risk (ER) of CVD mortality were 1.50% (95% CI: 0.51⁻2.50%) and 2.09% (95% CI: 0.79⁻3.41%), respectively. While PM2.5 concentration of lag2 and lag02 rose by 10 µg/m³, the ER of IHD mortality were 2.87% (95% CI: 0.71⁻5.07%) and 3.86% (95% CI: 1.17⁻6.63%), respectively. While PM2.5 concentration of lag4 and lag04 rose by 10 µg/m³, the ER of EVD mortality were 2.09% (95% CI: 2.28⁻3.92%) and 3.08% (95% CI: 0.68⁻5.53%), respectively. CONCLUSIONS: PM2.5 increased CVD mortality. The government needs to strengthen the governance of air pollution in areas with a slight pollution.


Assuntos
Poluentes Atmosféricos/análise , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/mortalidade , Exposição por Inalação/análise , Material Particulado/análise , Transtornos Cerebrovasculares/epidemiologia , Transtornos Cerebrovasculares/mortalidade , China/epidemiologia , Cidades , Humanos , Modelos Estatísticos , Isquemia Miocárdica/epidemiologia , Isquemia Miocárdica/mortalidade , Tamanho da Partícula
17.
Neurosci Lett ; 656: 83-88, 2017 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-28735085

RESUMO

This study aimed to elucidate the protective effect of minocycline against streptomycin-induced damage of cochlear hair cells and its mechanism. Cochlear membranes were isolated from newborn Wistar rats and randomly divided into control, 500µmol/L streptomycin, 100µmol/L minocycline, and streptomycin and minocycline treatment groups. Hair cell survival was analyzed by detecting the expression of 3-nitrotyrosine (3-NT) in cochlear hair cells by immunofluorescence and an enzyme-linked immunosorbent assay. Expression of 3-NT and inducible nitric oxide synthase (iNOS), and poly (ADP-Ribose) polymerase (PARP) and caspase-3 activation were evaluated by western blotting. The results demonstrated hair cell loss at 24h after streptomycin treatment. No change was found in supporting cells of the cochleae. Minocycline pretreatment improved hair cell survival and significantly reduced the expression of iNOS and 3-NT in cochlear tissues compared with the streptomycin treatment group. PARP and caspase-3 activation was increased in the streptomycin treatment group compared with the control group, and pretreatment with minocycline decreased cleaved PARP and activated caspase-3 expression. Minocycline protected cochlear hair cells from injury caused by streptomycin in vitro. The mechanism underlying the protective effect may be associated with the inhibition of excessive formation of nitric oxide, reduction of the nitration stress reaction, and inhibition of PARP and caspase-3 activation in cochlear hair cells. Combined minocycline therapy can be applied to patients requiring streptomycin treatment.


Assuntos
Antibacterianos/toxicidade , Células Ciliadas Auditivas/efeitos dos fármacos , Minociclina/farmacologia , Fármacos Neuroprotetores/farmacologia , Óxido Nítrico/metabolismo , Poli(ADP-Ribose) Polimerases/metabolismo , Estreptomicina/toxicidade , Animais , Caspase 3/metabolismo , Morte Celular , Cóclea/efeitos dos fármacos , Cóclea/metabolismo , Cóclea/patologia , Ativação Enzimática , Células Ciliadas Auditivas/citologia , Óxido Nítrico Sintase Tipo II/metabolismo , Ratos Wistar , Transcrição Genética , Tirosina/análogos & derivados , Tirosina/metabolismo
18.
Environ Sci Pollut Res Int ; 24(25): 20261-20272, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28702913

RESUMO

Although the growths of ambient pollutants have been attracting public concern, the characteristic of the associations between air pollutants and mortality remains elusive. Time series analysis with a generalized additive model was performed to estimate the associations between ambient air pollutants and mortality outcomes in Shenzhen City for the period of 2012-2014. The results showed that nitrogen dioxide (NO2)-induced excess risks (ER) of total non-accidental mortality and cardiovascular mortality were significantly increased (6.05% (95% CI 3.38%, 8.78%); 6.88% (95% CI 2.98%, 10.93%), respectively) in interquartile range (IQR) increase analysis. Also, these associations were strengthened after adjusting for other pollutants. Moreover, similar associations were estimated for sulfur dioxide (SO2), particulate matter with an aerodynamic diameter of <10 µm (PM10), and total non-accidental mortality. There were significant higher ERs of associations between PM10 and mortality for men than women; while there were significant higher ERs of associations between PM10/NO2 and mortality for elders (65 or elder) than youngers (64 or younger). Season analyses showed that associations between NO2 and total non-accidental mortality were more pronounced in hot seasons than in warm seasons. Taken together, NO2 was positively associated with total non-accidental mortality and cardiovascular mortality in Shenzhen even when the concentrations were below the ambient air quality standard. Policy measures should aim at reducing residents' exposure to anthropogenic NO2 emissions.


Assuntos
Poluentes Atmosféricos/toxicidade , Poluição do Ar/efeitos adversos , Monitoramento Ambiental , Mortalidade , Poluentes Atmosféricos/análise , Poluição do Ar/análise , China , Estudos Epidemiológicos , Feminino , Humanos , Masculino , Dióxido de Nitrogênio/análise , Dióxido de Nitrogênio/toxicidade , Material Particulado/análise , Material Particulado/toxicidade , Fatores de Risco , Dióxido de Enxofre/análise , Dióxido de Enxofre/toxicidade
19.
Front Psychol ; 7: 505, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27092100

RESUMO

Right hand responds faster than left hand when shown larger numbers and vice-versa when shown smaller numbers (the SNARC effect). Accumulating evidence suggests that the SNARC effect may not be exclusive for numbers and can be extended to other ordinal sequences (e.g., months or letters in the alphabet) as well. In this study, we tested the SNARC effect with a non-numerically ordered sequence: the Chinese notations for the color spectrum (Red, Orange, Yellow, Green, Blue, Indigo, and Violet). Chinese color word sequence reserves relatively weak ordinal information, because each element color in the sequence normally appears in non-sequential contexts, making it ideal to test the spatial organization of sequential information that was stored in the long-term memory. This study found a reliable SNARC-like effect for Chinese color words (deciding whether the presented color word was before or after the reference color word "green"), suggesting that, without access to any quantitative information or exposure to any previous training, ordinal representation can still activate a sense of space. The results support that weak ordinal information without quantitative magnitude encoded in the long-term memory can activate spatial representation in a comparison task.

20.
Forsch Komplementmed ; 22(2): 94-100, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26021959

RESUMO

BACKGROUND: Whether subgroups of functional dyspepsia (FD) should be treated with different approaches is controversially discussed in research. As our previous study has demonstrated the effect of acupuncture in FD treatment, we now further analyze the therapeutic effect of acupuncture in the treatment of postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). METHODS: A retrospective analysis was conducted in 465 eligible PDS patients and 241 EPS patients. 4 acupuncture groups (group A: specific acupoints along the stomach meridian; group B: non-specific acupoints along the stomach meridian; group C: alarm and transport acupoints; group D: specific acupoints along the gallbladder meridian) were compared with a non-acupoint sham acupuncture group and an itopride group. The patients were treated in 5 consecutive sessions per week for 4 weeks and were followed-up for 12 weeks afterwards. Primary outcome of the study was defined as response rate and symptom improvement as measured by the Symptom Index of Dyspepsia, while secondary outcome was designated as improvement in quality of life (QoL) as determined by the Nepean Dyspepsia Index. RESULTS: Symptoms of dyspepsia and QoL were improved from baseline in all groups. In EPS patients, no statistically significant differences could be observed in response rate (p = 0.239) and symptoms improvement (p = 0.344 for epigastric pain; p = 0.465 for epigastric burning). In contrast, PDS patients of the acupuncture group A showed higher response rate (53.2% vs. 19.7%, p<0.001; 53.2% vs. 35.1%, p = 0.025) and score change in postprandial fullness (1.01 vs. 0.27, p<0.001; 1.01 vs. 0.57, p<0.001), early satiation (0.81 vs. 0.21, p<0.001; 0.81 vs. 0.39, p=0.001), and QoL (14.5 vs. 4.33, p<0.001; 14.5 vs. 8.5, p<0.001) compared to the sham acupuncture and itopride group. CONCLUSIONS: FD patients with PDS responded better to the acupuncture therapies, especially at the specific acupoints along the stomach meridian. The positive therapeutic effect of acupuncture on PDS was correlated with the improvement in postprandial fullness. TRIAL REGISTRATION: ClinicalTrial.gov NCT00599677.


Assuntos
Terapia por Acupuntura/normas , Dispepsia/terapia , Dispepsia/classificação , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Estudos Retrospectivos , Resultado do Tratamento
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