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1.
J Glob Health ; 10(1): 010417, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32373333

RESUMO

Background: We conducted a meta-analysis to explore the relationship between exposure to air pollution and the risk of cognitive impairment of longitudinal cohort studies. Methods: PubMed, Web of Science and Wan Fang databases were searched for relevant articles of longitudinal cohort studies published between January 1950 and September 2019. The pooled relative ratio (RR) and 95% confidence interval (CI) were calculated using the random effect model. Results: Ten articles involving 519 247 cases among 12 523 553 participants were included in this meta-analysis. The pooled RR of cognitive impairment per 5 µg/m3 increments in exposure to particulate matter ≤2.5 µm (PM2.5) was 1.08 (95% CI = 1.03, 1.13; I2 = 82.2%; Pheterogeneity <0.001). No association was found between nitrogen dioxide/nitrogen oxide (NO2/NOx) and ozone (O3) and cognitive impairment. For PM2.5 exposure, in subgroup analysis, the above-mentioned significant positive association was found among studies conducted in population (RR p er 5 µg/m 3 = 1.05; 95% CI = 1.01,1.09; I2 = 57.4%; Pheterogeneity = 0.016), in North America (RR per 5 µg/m 3 = 1.13; 95% CI = 1.01,1.26; I2 = 86.7%; Pheterogeneity <0.001) and with follow-up duration >10 years (RR p er 5 µg/m 3 = 1.10; 95% CI = 1.03,1.17; I2 = 86.3%; Pheterogeneity <0.001). Conclusions: This meta-analysis suggests that exposure to PM2.5 might increase the risk of cognitive impairment.

2.
Front Immunol ; 11: 746, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32431700

RESUMO

In dairy herds, mastitis caused by Staphylococcus aureus is difficult to completely cure on the account that S. aureus can invade bovine mammary epithelial cells (BMECs) and result in persistent infection in the mammary gland. Recent studies have demonstrated that autophagy can participate in cell homeostasis by eliminating intracellular microorganisms. The aim of the study was to investigate why S. aureus can evade autophagy clearance and survive in BMECs. The intracellular infection model was first constructed; then, the bacteria in autophagosome was detected by transmission electron microscopy. The autophagy flux induced by the S. aureus was also evaluated by immunoblot analysis and fluorescent labeling method for autophagy marker protein LC3. In addition, lysosomal alkalization and degradation ability were assessed using confocal microscopy. Results showed that, after infection, a double-layer membrane structure around the S. aureus was observed in BMECs, indicating that autophagy occurred. The change in autophagy marker protein and fluorescent labeling of autophagosome also confirmed autophagy. However, as time prolonged, the autophagy flux was markedly inhibited, leading to obvious autophagosome accumulation. At the same time, the lysosomal alkalization and degradation ability of BMECs were impaired. Collectively, these results indicated that S. aureus could escape autophagic degradation by inhibiting autophagy flux and damaging lysosomal function after invading BMECs.

3.
Inorg Chem ; 2020 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-32125835

RESUMO

An ilmenite-like monoclinic phase of HgMnO3 with space group P21/c was prepared using high-pressure and high-temperature methods at 18 GPa and 1473 K. The MnO6 octahedra form a two-dimensional (2D) network in the bc plane, leading to a long-range antiferromagnetic ordering with a low Néel temperature of TN ∼ 32 K. As the synthesis pressure increases to 20 GPa, a new perovskite-like rhombohedral phase with space group R3̅c was found to occur. The rhombohedral phase exhibits a three-dimensional (3D) network for the MnO6 octahedra, giving rise to an antiferromagnetic ordering at TN ∼ 60 K. X-ray absorption spectroscopy confirms the invariable Mn4+ charge state in these two polymorphic phases, in agreement with the Curie-Weiss and bond valence sum analysis. HgMnO3 provides an interesting example to study the magnetic properties from 2D to 3D by varying synthesis pressure.

4.
Transbound Emerg Dis ; 2020 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-32163661

RESUMO

Coronaviruses (CoVs) are found in humans and a wide variety of wild and domestic animals, and of substantial impact on human and animal health. In poultry, the genetic diversity, evolution, distribution and taxonomy of CoVs dominant in birds other than chickens remain enigmatic. In our previous study, we proposed that the CoVs dominant (i.e. mainly circulating) in ducks (DdCoVs) should represent a novel species, which was different from the one represented by the CoVs dominant in chickens (CdCoVs). In this study, we conducted a large-scale surveillance of CoVs in chickens, ducks, geese, pigeons and other birds (quails, sparrows and partridges) using a conserved RT-PCR assay. The surveillance demonstrated that CdCoVs, DdCoVs and the CoVs dominant in pigeons (PdCoVs) belong to different lineages, and they are all prevalent in live poultry markets and the backyard flocks in some regions of China. We further sequenced seven Coronaviridae-wide conserved domains in their replicase polyprotein pp1ab of seven PdCoVs and found that the genetic distances in these domains between PdCoVs and DdCoVs or CdCoVs are large enough to separate PdCoVs into a novel species, which were different from the ones represented by DdCoVs or CdCoVs within the genus Gammacoronavirus, per the species demarcation criterion of International Committee on Taxonomy of Viruses. This report shed novel insight into the genetic diversity, distribution, evolution and taxonomy of avian CoVs.

5.
Cell Biochem Biophys ; 2020 Mar 09.
Artigo em Inglês | MEDLINE | ID: mdl-32152961

RESUMO

The exact expression profile and potential involvement of miR-625-5p in the tumor biology of cervical carcinoma are still elusive. In this study, we aimed to analyze the expression status and possible involvements of miR-625-5p in both clinical tissue samples and cell culture of cervical carcinoma. The relative expression levels of miR-625-5p and NF-κB transcript were determined by real-time polymerase chain reaction. Cell proliferation was measured using Cell Counting Kit-8. The protein levels of Cyclin D1, CDK4, NF-κB, and GAPDH were examined by Western blotting. The regulatory effects of miR-625-5p on NF-κB and MALAT1 were interrogated by luciferase reporter assay. We demonstrated that miR-625-5p was downregulated and predicted better survival in cervical carcinoma. Ectopic over-expression of miR-625-5p inhibited cell growth via targeting NF-κB. We further identified MALAT1 as the competitive endogenous long non-coding RNA for miR-625-5p, and over-expression of MALAT1 attenuated the inhibitory effect of miR-625-5p on NF-κB signaling in cervical carcinoma. Our study characterized the suppressive expression of miR-625-5p in cervical carcinoma and unraveled the importance of MALAT1/miR-625-5p/NF-κB signaling in this disease.

6.
Transbound Emerg Dis ; 2020 Feb 17.
Artigo em Inglês | MEDLINE | ID: mdl-32065513

RESUMO

In recent decades, multiple subtypes (i.e. H9N2, H5N1 and H7N9) of avian influenza virus (AIV) have become widespread in China, which has caused enormous economic losses and posed considerable threats to public health. In this review, with the aim to provide insights into and guidelines for the control of AIV spread in China and globally in the future, we analysed the reasons why AIV has persisted in China based on socio-economic features, including poultry biosecurity, live bird markets, live bird transportation, wild birds, poultry waterfowl, poultry density, poultry population and infected birds. We also described the present status of the AIV subtypes H9, H5 and H7 in China to elucidate the effectiveness of the strategies currently employed in China (i.e. culling, mass vaccination and biosecurity improvement) to control the disease based on a literature review and our unpublished surveillance data collected over a 12-year period from 2007 to 2018. We then summarized the lessons to be learned from the control experience in China, including whether culling of infected birds is of limited value for disease control and whether improved biosecurity is a better option than culling and vaccination for the long-term control of AIV, and when the vaccine strain should be updated.

7.
Sci Rep ; 10(1): 1724, 2020 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-32015423

RESUMO

S100A12 belongs to the S100 family and acts as a vital regulator in different types of tumors. However, the function of S100A12 in thyroid carcinoma has not yet been investigated. In this study, we analyzed the expression of S100A12 in human papillary thyroid cancer (PTC) samples and two PTC cell lines. In addition, we explored the effects of S100A12 on PTC cell progression in vitro and in vivo. Our results showed that S100A12 was significantly upregulated in PTC specimens. Moreover, silencing S100A12 markedly inhibited PTC cell proliferation, migration, invasion and cell cycle progression. In addition, knockdown of S100A12 significantly reduced the expression of CyclinD1, CDK4 and p-ERK in PTC cells. An in vivo study also showed that silencing S100A12 dramatically suppressed tumor cell growth and decreased Ki67 expression in a xenograft mouse model. This study provides novel evidence that S100A12 serves as an oncogene in PTC. Knockdown of S100A12 suppressed PTC cell proliferation, migration, and invasion and induced G0/G1 phase arrest via the inhibition of the ERK signaling pathway. Therefore, S100A12 may be a potent therapeutic target for PTC.

8.
Biosci Biotechnol Biochem ; 84(3): 471-480, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31694485

RESUMO

This study aimed to explore the influence of Tryptophanyl-tRNA synthetase (WARS) expression on the proliferation and migration of uveal melanoma (UM) cells, and the potential mechanisms. Bioinformatics analysis based on Gene Expression Omnibus (GEO) database showed that WARS expression in metastatic cancer was significantly higher than that in no-metastatic group. Kaplan-Meier analysis based on The Cancer Genome Atlas (TCGA) database showed that high WARS expression was associated with lower survival. Biological function experiments showed that overexpression of WARS in OCM-1A cells can promote cell proliferation, migration, and invasion, whereas knockdown of WARS in C918 cells showed the opposite effect. Finally, we observed that the up-regulation of WARS induced the activation of phosphatidylinositol 3-kinase/AKT (PI3K/AKT) signaling, whilst depletion of WARS resulted in opponent outcomes. Taken together, our results illustrated that WARS was overexpressed in UM cells and contributed to the viability and motility of UM cells via modulating PI3K/AKT signaling pathway.


Assuntos
Melanoma/metabolismo , Triptofano-tRNA Ligase/metabolismo , Neoplasias Uveais/metabolismo , Linhagem Celular Tumoral , Proliferação de Células , Humanos , Melanoma/enzimologia , Melanoma/patologia , Regulação para Cima , Neoplasias Uveais/enzimologia , Neoplasias Uveais/patologia
9.
Toxicol In Vitro ; 62: 104677, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31629067

RESUMO

Doxorubicin (DOX) has dose-dependent toxicity on ovarian follicles (OFs), and the inhibition of different signaling molecules along with the DOX application for enhancing its efficacy can also upsurge this toxicity. Therefore, it is strongly required to explore the mechanism of DOX-induced toxicity in 3D culture systems for protecting the OFs. A microfluidic chip was used to culture a single OF to identify the potential signaling molecules and their combined effects on OFs dynamically. The chip offers better 3D biomimetic microenvironment to the growing OF than 2D culture systems. The OFs cultured on the chip were treated with DOX and the inhibitors of Src, Ca2+, and PIM. Their mutual effects were studied on OFs growth and 17ß-estradiol secretion. Besides, the RNA levels of B4GALT2 and UNC5C genes of DOX-exposed OFs were detected by RT-qPCR, and TUNEL staining experiments were conducted to check the OF apoptosis. The results showed that DOX application reduced the OFs growth and hormone secretion and induced apoptosis in the OFs. Moreover, the DOX-induced toxic effects were enriched by Src and PIM inhibition, while reduced by the ER-Ca2+ channel inhibitor. This study specifically demonstrates the synergistic effects of some signaling molecules on DOX-mediated cellular functions of OFs and demands some meditative measures to decipher this toxicity for supporting the female endocrine and reproductive functions.


Assuntos
Antibióticos Antineoplásicos/toxicidade , Doxorrubicina/toxicidade , Folículo Ovariano/efeitos dos fármacos , Animais , Cálcio/metabolismo , Técnicas de Cultura de Células , Células Cultivadas , Feminino , Dispositivos Lab-On-A-Chip , Folículo Ovariano/metabolismo , Proteínas Proto-Oncogênicas c-pim-1/antagonistas & inibidores , Proteínas Proto-Oncogênicas c-pim-1/metabolismo , Ratos Sprague-Dawley , Quinases da Família src/antagonistas & inibidores , Quinases da Família src/metabolismo
10.
Emerg Infect Dis ; 26(2)2020 Feb 17.
Artigo em Inglês | MEDLINE | ID: mdl-31855533

RESUMO

In China, influenza A(H7N9) virus appeared in 2013, then mutated into a highly pathogenic virus, causing outbreaks among poultry and cases in humans. Since September 2017, extensive use of the corresponding vaccine, H7-Re1, successfully reduced virus prevalence. However, in 2019, a novel antigenic variant emerged, posing considerable economic and public health threats.A.

11.
World J Clin Cases ; 7(22): 3887-3894, 2019 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-31799319

RESUMO

BACKGROUND: Thyroxine-binding globulin (TBG; the gene product of SERPINA7) is the main transporter of thyroid hormones in humans. Mutations in the TBG gene may lead to inherited TBG deficiency. There have been 28 reported mutations that associate with complete TBG deficiency (TBG-CD). Here we identified a novel frameshift mutation causing early termination of the TBG protein and TBG-CD in a Chinese family. CASE SUMMARY: A 46-year-old Chinese man was referred to our hospital with normal free thyroxine, free triiodothyronine, thyrotropin, but lower total thyroxine and total triiodothyronine, and undetectable serum TBG, indicative of TBG-CD. Blood samples were obtained from the patient's family members and thyroid function and serum TBG were evaluated. Genomic DNA from peripheral blood was sequenced to detect possible TBG mutation(s). Quantitative PCR high-resolution melting curve analysis was used to screen TBG-Poly (L283F) among 117 Chinese men. A novel mutation of TBG (p.Phe135Alafs*21), a 19-nucleotide insertion in exon 1, was identified, which resulted in a truncated TBG protein product and caused TBG-CD. The other mutation, identified in the proband's father, is a known polymorphism, TBG-Poly (L283F). The frequency of the TBG-Poly allele among 117 unrelated Han Chinese men from northeast China was 21.37%. CONCLUSION: A novel mutation in the TBG gene associated with the TBG-CD phenotype was identified in a Chinese family. Additionally, it was found that 21.37% of Chinese males had TBG-Poly (L283F).

12.
Immunobiology ; : 151889, 2019 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-31812342

RESUMO

The genomic organization of goat immunoglobulin light chains (Igλ and Igκ) loci were annotated based on the goat genome database. The goat Igλ chain located on chromosome 17 contains at least 35 Vλ gene fragments (seven potential functional genes, one ORF and 27 pseudogenes), two Jλ-Cλ clusters arranged in a Vλ(35)-Jλ2-Cλ1-Jλ1-Cλ2 pattern, with another Cλ3 on scaffold. The Igκ locus included 11 Vκ (five potential functional genes, two ORFs and four pseudogene fragments), three Jκ genes and a single Cκ gene ordered in Vκ(35)-Jκ(3)-Cκ pattern on chromosome 11. By analyzing the clonies of Igλ and Igκ, we further found Vλ2 (26.23 %) &Vλ3 (73.11 %), Vκ2 (52.07 %) &Vκ4 (46.15 %) were predominately used in the expression of λ and κ chains respectively. λ chain showed more abundance in connective diversity than κ chain. Besides, somatic hypermutation with higher frequency in both immunoglobulin light chains was the major mechanism for the goat repertoire diversity. These results demonstrated goat immunoglobulin light chain variable region genome loci and repertoire diversity.

13.
Sci Rep ; 9(1): 18415, 2019 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-31804580

RESUMO

Currently, exercise-based cardiac rehabilitation (CR) is the only recommended secondary prevention strategy for cardiac patients that attempts to tackle stress and psychosocial wellbeing, but it is under-utilized and lacks a comprehensive curriculum for this purpose; hence there is a critical gap to address psychosocial needs of cardiac patients after an event. Mindfulness-based stress reduction (MBSR) has shown benefits in the general population but its role in cardiac patients is not clear. We conducted a pilot randomized controlled trial (RCT) of MBSR in CR-eligible cardiac patients during their initial year of recovery. Patients were allocated 2:1 (intervention:control) to an 8-week MBSR group intervention or usual care. Standard measures of depression, anxiety, perceived stress, health related quality of life (HRQOL), blood pressure, biomarkers (lipids, HbA1c, CRP) and 24-hour Holter monitoring were obtained at baseline, 3- and 9-months post-randomization. Sub-group analyses were performed for participants with at least mild depression (PHQ-9 ≥ 5). 47 patients [mean age 58.6 years; 38% female; 77% white] were enrolled in 2 cohorts. 87% of MBSR patients completed the intervention; study retention was >95% at each follow-up visit. At 3 months, compared to controls, MBSR patients showed improvements in depression [p = 0.01] and anxiety [p = 0.04] with a similar trend in HRQOL [p = 0.06]. The MBSR group showed greater improvement or less worsening of most CV risk factors, with an attenuation of treatment effects at 9 months. Participants with at PHQ-9 scores ≥5 at baseline showed greater improvement in psychosocial and CV outcomes, that persisted at 9 months. MBSR is a safe and well received secondary prevention strategy. This pilot RCT provides preliminary evidence of MBSR's potential to improve short term psychosocial well-being in cardiac patients during their first year of recovery.

14.
Chem Commun (Camb) ; 56(2): 265-268, 2019 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-31807742

RESUMO

The novel two-dimensional honeycomb layered Cu3LiRu2O6 exhibits Pauli-like paramagnetic and Mott variable range hopping semiconduction behaviors, which contradict the large specific-heat Sommerfeld coefficient for metals, and indicate a possible spin-excitation induced nonmetallic metal. This nonmetallic feature can be significantly suppressed by pressure toward producing a bad-metal state, as reflected by the temperature-dependent resistivity response up to 35 GPa.

15.
Artigo em Inglês | MEDLINE | ID: mdl-31752150

RESUMO

Objective: To describe the prevalence of metabolic syndrome (MetS) in adolescents and its association with several MetS-related biochemical markers. Methods: A cross-sectional analysis was carried out and data were extracted from the Nutrition and Health Surveillance in Primary and Secondary school students of Beijing (NHSPSB) 2017. Participants were aged 10-15 years old. MetS was diagnosed using the recommended criteria for Chinese adolescents. The associations among MetS, biochemical biomarkers, and socioeconomic status were estimated by multivariable linear regression. Results: The prevalence of MetS in adolescents in Beijing was 3% in the total sample, 4% in boys, and 2% in girls. Moreover, the prevalence of MetS in the overweight and obesity populations were 5% and 12% respectively. The prevalence of MetS remained higher in boys than in girls. The concentrations of alanine aminotransferase (ALT), serum uric acid (SUA), low density lipoprotein (LDL), and C-reactive protein (CRP) were higher in the MetS children in comparison with non-MetS children (All p < 0.05), while the high-density lipoprotein (HDL) concentration was lower in MetS children. After adjusting for socioeconomic parameters in the multivariable regression model, MetS was strongly associated with ALT, SUA, HDL, and LDL. The five components of MetS indicated that abdominal obesity and a high serum triglyceride (TG) concentration were tightly linked with ALT, SUA, LDL, and CRP; while a low HDL concentration and elevated blood pressure were related to enhanced ALT, UA, and CRP. Additionally, impaired fasting glucose was only related to increased ALT. Conclusion: The epidemiological issues of MetS in Beijing adolescents should be known across socioeconomic classes. Early intervention strategies, such as dietary pattern interventions and physical excise, should be designed for that population to reduce the disease burdens of cardiovascular disease (CVD), Type 2 diabetes (T2D), and steatohepatitis in adulthood.

17.
J Thorac Dis ; 11(9): 3769-3775, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31656649

RESUMO

Background: Few previous reports have evaluated lung specimen extraction method or how to improve lung specimen extraction method, especially with single-port thoracoscopic surgery. We evaluated the feasibility and surgical advantages of double-arm lung specimen extraction method by comparing double-arm vs. single-arm specimen extraction times. Methods: We retrospectively analyzed data for 268 patients undergoing partial lung resection via single-port thoracoscopy and specimen extraction using a specimen extractor in the Union Medical College Hospital of Fujian Medical University from November 2017 to June 2018. We divided patients into groups based on the specimen location as an upper-lobe group (group I), lower-lobe group (group II), and lung-segment group (group III). We then performed a subgroup analysis based on the degree of collapse of the lung lobe specimens during extraction as follows: good in group IA and IIA, and poor in group IB and IIB. Results: The double-arm method required statistically significantly less time than the single-arm method: (69.6±31.9 vs. 89.9±47.8 s, respectively, P=0.037). We found no significant difference in lung specimen extraction time for double-arm vs. single-arm extraction in group I, II, or III (P=0.093, P=0.153, P=0.174, respectively). We also found no significant difference in lung specimen extraction time between the two methods in group IA and group IIA (P=0.165, P=0.649, respectively). However, in groups IB and IIB, extraction time with the double-arm method was significantly shorter compared with the single-arm method (64.4±12.3 vs. 89.1±12.1 s, P=0.034 and 113.8±27.1 vs. 160.0±31.8 s, P=0.042, respectively). Conclusions: In single-port thoracoscopic partial lung resection, double-arm specimen extraction method is more convenient and can shorten sample extraction time, especially for upper- and lower-lung lobes with poor degree of collapse. Double-arm specimen extraction method is feasible and effective after single-port thoracoscopic partial lung resection.

18.
FEBS Open Bio ; 9(12): 2080-2092, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31642613

RESUMO

Cervical squamous cell carcinoma (CSCC) accounts for a significant proportion of cervical cancer; thus, there is a need for novel and noninvasive diagnostic biomarkers for this malignancy. In this study, we performed integrated analysis of a dataset from the Gene Expression Omnibus database to identify differentially expressed genes (DEGs) and differentially expressed miRNAs (DEmiRNAs) between CSCC, cervical intraepithelial neoplasia (CIN) and healthy control subjects. We further established protein-protein interaction and DEmiRNA-target gene interaction networks, and performed functional annotation of the target genes of DEmiRNAs. In total, we identified 1375 DEGs and 19 DEmiRNAs in CIN versus normal control, and 2235 DEGs and 33 DEmiRNAs in CSCC versus CIN by integrated analysis. Our protein-protein interaction network indicates that the common DEGs, Cyclin B/cyclin-dependent kinase 1 (CDK1), CCND1, ESR1 and Aurora kinase A (AURKA), are the top four hub genes. P53 and prostate cancer were identified as significantly enriched signaling pathways of common DEGs and DEmiRNA targets, respectively. We validated that expression levels of three DEGs (TYMS, SASH1 and CDK1) and one DEmiRNA of hsa-miR-99a were altered in blood samples of patients with CSCC. In conclusion, a total of four DEGs (TYMS, SASH1, CDK1 and AURKA) and two DEmiRNAs (hsa-miR-21 and hsa-miR-99a) may be involved in the pathogenesis of CIN and the progression of CIN into CSCC. Of these, TYMS is predicted to be regulated by hsa-miR-99a and SASH1 to be regulated by hsa-miR-21.

19.
Chin Med J (Engl) ; 132(18): 2143-2149, 2019 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-31478926

RESUMO

BACKGROUND: Thyroid autoimmunity (TAI) is prevalent among women of reproductive age and associated with adverse pregnancy outcomes. This study aimed to investigate the association between iron nutritional status and the prevalence of TAI in women during the first trimester of pregnancy and in non-pregnant women of childbearing age. METHODS: Cross-sectional analysis of 7463 pregnant women during the first trimester of pregnancy and 2185 non-pregnant women of childbearing age nested within the sub-clinical hypothyroid in early pregnancy study, a prospective collection of pregnant and non-pregnant women's data, was conducted in Liaoning province of China between 2012 and 2015. Serum thyrotropin, free thyroxine, thyroid peroxidase antibodies (TPOAbs), thyroglobulin antibodies (TgAbs), serum ferritin, and urinary iodine were measured. Iron deficiency (ID) was defined as serum ferritin <15 µg/L and iron overload (IO) was defined as ferritin >150 µg/L. TPOAb-positive was defined as >34 U/mL and TgAb-positive was defined as >115 U/mL. Multilevel logistic regression was conducted to examine the association between TAI and different iron nutritional status after adjusting for potential confounders. RESULTS: The prevalence of isolated TPOAb-positive was markedly higher in women with ID than those without ID, in both pregnant and non-pregnant women (6.28% vs. 3.23%, χ = 10.264, P = 0.002; 6.25% vs. 3.70%, χ = 3,791, P = 0.044; respectively). After adjusting for confounders and the cluster effect of hospitals, ID remained associated with TPOAb-positive in pregnant and non-pregnant women (odds ratio [OR]: 2.111, 95% confidence interval [CI]: 1.241-3.591, P = 0.006; and OR: 1.822, 95% CI: 1.011-3.282, P = 0.046, respectively). CONCLUSION: ID was associated with a higher prevalence of isolated TPOAbs-positive, but not with isolated TgAb-positive, in both pregnant women during the first trimester of pregnancy and non-pregnant women of childbearing age, while IO was not associated with either isolated TPOAb-positive or isolated TgAb-positive. CLINICAL TRIAL REGISTRATION: ChiCTR-TRC-13003805, http://www.chictr.org.cn/index.aspx.

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