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1.
J Colloid Interface Sci ; 606(Pt 2): 1163-1169, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34487935

RESUMO

Mn-doped perovskite nanocrystals have promised new optoelectronic applications due to their unique material properties. In the present study, Mn-doped perovskite nanocrystalline films were prepared in situ in a polymer matrix. The Mn-doped perovskite nanocrystals (PNCs) had good crystallinity and uniform size/spatial distributions in the polymer film. Bright dual-color emission and the long lifetime of the excited state of the dopant were observed from the host exciton and the Mn2+ dopant, respectively. Furthermore, magnetism was observed in the optimal Mn2+ concentration, implying that magnetic coupling was achieved in the Mn-doped perovskite lattice. The Mn-doped perovskite films also showed superior stability against moisture. To demonstrate the practicality of this composite film, a white light emitting device was fabricated by combining a single composite film with a blue light emitting diode; the device showed a high-quality white light emission, and the Commission Internationale De L'Eclairage (CIE) chromaticity coordinate of the white light emitting diode (WLED) (0.361, 0.326) was close to the optimal white color index. In this single-layer WLED, self-absorption among the luminous multilayers in traditional white light emitting diodes can be avoided. The study findings revealed that Mn-doped perovskite nanocrystalline films have many exciting properties, which bodes well for the fundamental study and design of high-performance optoelectronic devices.

2.
Dis Markers ; 2021: 2409820, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34795805

RESUMO

Enhancer RNAs (eRNAs), a subclass of noncoding RNAs from enhancers, have been demonstrated to exhibit important regulatory effects on the expressions of various genes. However, the role of eRNAs in skin cutaneous melanoma (SKCM) remained largely unclear. In this study, we aimed to explore the expression and prognostic value of an enhancer RNA TEX41 in SKCM as well as the associations between TEX41 and tumor-infiltrating immune cells (TICs). We observed that TEX41 expression was distinctly increased in SKCM specimens compared with normal skin specimens using GEPIA. Survival assays based on TGCA datasets revealed that patients with low TEX41 expressions displayed a longer overall survival than those with high TEX41 expression. CIBERSORT datasets revealed that TEX41 was related to 8 types of TICs (macrophages M1, T cells regulatory, plasma cells, mast cells resting, T cells CD8, dendritic cells resting, and T cells follicular helper). Three kinds of TICs were negatively related to TEX41 expressions, including macrophages M2, NK cells resting, and macrophages M0. The expressions of TEX41 were involved in five KEGG pathways, including transcriptional misregulation in cancer, SNARE interactions in vesicular transport, mitophagy-animal, melanoma, melanogenesis, and progesterone-mediated oocyte maturation. Overall, TEX41 can be used as a novel biomarker for the prognosis of SKCM patients and is associated with TICs, indicating it as a therapeutic target for SKCM.

3.
Adv Sci (Weinh) ; : e2101527, 2021 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-34719890

RESUMO

Chemodynamic therapy (CDT) is an emerging treatment that usually employs chemical agents to decompose hydrogen peroxide (H2 O2 ) into hydroxyl radical (•OH) via Fenton or Fenton-like reactions, inducing cell apoptosis or necrosis by damaging biomacromolecules such as, lipids, proteins, and DNA. Generally, CDT shows high tumor-specificity and minimal-invasiveness in patients, thus it has attracted extensive research interests. However, the catalytic reaction efficiency of CDT is largely limited by the relatively high pH at the tumor sites. Herein, a 808 nm laser-potentiated peroxidase catalytic/mild-photothermal therapy of molybdenum diphosphide nanorods (MoP2 NRs) is developed to improve CDT performance, and simultaneously achieve effective tumor eradication and anti-infection. In this system, MoP2 NRs exhibit a favorable cytocompatibility due to their inherent excellent elemental biocompatibility. Upon irradiation with an 808 nm laser, MoP2 NRs act as photosensitizers to efficiently capture the photo-excited band electrons and valance band holes, exhibiting enhanced peroxidase-like catalytic activity to sustainedly decompose tumor endogenous H2 O2 to •OH, which subsequently destroy the cellular biomacromolecules both in tumor cells and bacteria. As demonstrated both in vitro and in vivo, this system exhibits a superior therapeutic efficiency with inappreciable toxicity. Hence, the work may provide a promising therapeutic technique for further clinical applications.

4.
Nanoscale ; 13(43): 18084-18088, 2021 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-34730160

RESUMO

This communication describes a novel water-soluble membrane prepared from chitosan intended for SARS-CoV-2 viral nucleic acid collection and detection. The CSH membrane formed from nanofibers shows promising potential in the quantitative determination of the SARS-CoV-2 viral nucleic acids at a concentration of 102 copies per L in air. The sponge-like structure which allows gas to pass through for collection of viral nucleic acids potentially provides simple, fast, and reliable sampling as well as detection of various types of airborne viruses.


Assuntos
COVID-19 , Ácidos Nucleicos , Humanos , RNA Viral , SARS-CoV-2 , Manejo de Espécimes , Água
5.
ACS Appl Mater Interfaces ; 13(43): 50988-50995, 2021 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-34689562

RESUMO

Two-dimensional (2D) semiconductors are promising photocatalysts; in order to overcome the relatively low efficiency of single-component 2D photocatalysts, heterostructures are fabricated for effective charge separation. Herein, a 2D heterostructure is synthesized by anchoring nickel nanoparticle-decorated black phosphorus (BP) nanosheets to graphitic carbon nitride (CN) nanosheets (CN/BP@Ni). The CN/BP@Ni heterostructure exhibits an enhanced charge separation due to the tight interfacial interaction and the cascaded electron-transfer channel from CN to BP and then to Ni nanoparticles. Possessing abundant active sites of Ni and P-N coordinate bonds, CN/BP@Ni shows a high visible-light-driven H2 evolution rate of 8.59 mmol·h-1·g-1 with the sacrificial agent EtOH, about 10-fold to that of CN/BP. When applying benzyl alcohol to consume photogenerated holes, CN/BP@Ni enables the selective production of benzaldehyde; therefore, two value-added products are obtained in a single closed redox cycle. This work provides new insights into the development of photocatalysts without non-noble metals.

6.
Biology (Basel) ; 10(10)2021 Oct 13.
Artigo em Inglês | MEDLINE | ID: mdl-34681136

RESUMO

A carrier-free CRISPR/Cas9 ribonucleoprotein delivery strategy for genome editing mediated by a cold atmospheric plasma (CAP) is described. The CAP is promising in many biomedical applications due to efficient production of bioactive ionized species. The MCF-7 cancer cells after CAP exposure exhibit increased extracellular reactive oxygen and nitrogen species (RONS) and altered membrane potential and permeability. Hence, transmembrane transport of Ca2+ into the cells increases and accelerates ATP hydrolysis, resulting in enhanced ATP-dependent endocytosis. Afterwards, the increased Ca2+ and ATP contents promote the release of cargo into cytoplasm due to the enhanced endosomal escape. The increased membrane permeability also facilitates passive diffusion of foreign species across the membrane into the cytosol. After CAP exposure, the MCF-7 cells incubated with Cas9 ribonucleoprotein (Cas9-sgRNA complex, Cas9sg) with a size of about 15 nm show 88.9% uptake efficiency and 65.9% nuclear import efficiency via passive diffusion and ATP-dependent endocytosis pathways. The efficient transportation of active Cas9sg after the CAP treatment leads to 21.7% and 30.2% indel efficiencies in HEK293T and MCF-7 cells, respectively. This CAP-mediated transportation process provides a simple and robust alternative for the delivery of active CRISPR/Cas9 ribonucleoprotein. Additionally, the technique can be extended to other macro-biomolecules and nanomaterials to cater to different biomedical applications.

7.
Small ; 17(40): e2103239, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34486220

RESUMO

Nanomaterial-based photothermal and photocatalytic therapies are effective against various types of cancers. However, combining two or more materials is considered necessary to achieve the synergistic anticancer effects of photothermal and photocatalytic therapy, which made the preparation process complicated. Herein, the authors describe simple 2D titanium diselenide (TiSe2 ) nanosheets (NSs) that can couple photothermal therapy with photocatalytic therapy. The TiSe2 NSs are prepared using a liquid exfoliation method. They show a layered structure and possess high photothermal conversion efficiency (65.58%) and good biocompatibility. Notably, upon near-infrared irradiation, these NSs exhibit good photocatalytic properties with enhanced reactive oxygen species generation and H2 O2 decomposition in vitro. They can also achieve high temperatures, with heat improving their catalytic ability to further amplify oxidative stress and glutathione depletion in cancer cells. Furthermore, molecular mechanism studies reveal that the synergistic effects of photothermal and enhanced photocatalytic therapy can simultaneously lead to apoptosis and necrosis in cancer cells via the HSP90/JAK3/NF-κB/IKB-α/Caspase-3 pathway. Systemic exploration reveals that the TiSe2 NSs has an appreciable degradation rate and accumulates passively in tumor tissue, where they facilitate photothermal and photocatalytic effects without obvious toxicity. Their study thus indicates the high potential of biodegradable TiSe2 NSs in synergistic phototherapy for cancer treatment.


Assuntos
Nanopartículas , Neoplasias , Humanos , Raios Infravermelhos , Fototerapia , Titânio
8.
Nanoscale ; 13(33): 13923-13942, 2021 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-34477675

RESUMO

Owing to their peculiar oxidative effect, silver cations (Ag+) are well known for their antimicrobial properties and explored as therapeutic agents for biomedical applications. Size control with improved dispersion and stability are the key factors of Ag NPs (silver nanoparticles) to be used in biomedical applications. Silver based nano-materials are highly efficient due to their biological, chemical and physical properties in comparison with bulk silver. Atomic scale fabrication is achieved by rearranging the internal components of a material, in turn, influencing the mechanical, electrical, magnetic, thermal and chemical properties. For instance, size and shape have a strong impact on the optical, thermal and catalytic properties of Ag NPs. Such properties can be tuned by controlling the surface/volume ratio of Ag nanostructures with a small size (ideally <100 nm), in turn showing peculiar biological activity different from that of bulk silver. Silver nanomaterials such as nanoparticles, thin films and nanorods can be synthesized by various physical, chemical and biological methods whose most recent implementations will be described in this review. By controlling the structure-functionality relationship, silver based nano-materials have high potential for commercialization in biomedical applications. Antimicrobial, antifungal, antiviral, and anti-inflammatory Ag NPs can be applied in several fields such as pharmaceutics, sensors, coatings, cosmetics, wound healing, bio-labelling agents, antiviral drugs, and packaging.


Assuntos
Anti-Infecciosos , Nanopartículas Metálicas , Nanoestruturas , Antibacterianos/farmacologia , Anti-Infecciosos/farmacologia , Prata
9.
Nat Nanotechnol ; 16(10): 1150-1160, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34354264

RESUMO

Although nanomaterials have shown promising biomedical application potential, incomplete understanding of their molecular interactions with biological systems prevents their inclusion into mainstream clinical applications. Here we show that black phosphorus (BP) nanomaterials directly affect the cell cycle's centrosome machinery. BP destabilizes mitotic centrosomes by attenuating the cohesion of pericentriolar material and consequently leads to centrosome fragmentation within mitosis. As a result, BP-treated cells exhibit multipolar spindles and mitotic delay, and ultimately undergo apoptosis. Mechanistically, BP compromises centrosome integrity by deactivating the centrosome kinase polo-like kinase 1 (PLK1). BP directly binds to PLK1, inducing its aggregation, decreasing its cytosolic mobility and eventually restricting its recruitment to centrosomes for activation. With this mechanism, BP nanomaterials show great anticancer potential in tumour xenografted mice. Together, our study reveals a molecular mechanism for the tumoricidal properties of BP and proposes a direction for biomedical application of nanomaterials by exploring their intrinsic bioactivities.

10.
Adv Mater ; 33(32): e2101717, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34219296

RESUMO

Most contemporary X-ray detectors adopt device structures with non/low-gain energy conversion, such that a fairly thick X-ray photoconductor or scintillator is required to generate sufficient X-ray-induced charges, and thus numerous merits for thin devices, such as mechanical flexibility and high spatial resolution, have to be compromised. This dilemma is overcome by adopting a new high-gain device concept of a heterojunction X-ray phototransistor. In contrast to conventional detectors, X-ray phototransistors allow both electrical gating and photodoping for effective carrier-density modulation, leading to high photoconductive gain and low noise. As a result, ultrahigh sensitivities of over 105  µC Gyair -1  cm-2 with low detection limit are achieved by just using an ≈50 nm thin photoconductor. The employment of ultrathin photoconductors also endows the detectors with superior flexibility and high imaging resolution. This concept offers great promise in realizing well-balanced detection performance, mechanical flexibility, integration, and cost for next-generation X-ray detectors.

12.
Biomaterials ; 275: 120950, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34119886

RESUMO

Clinical treatment of Osteosarcoma (OS) encounters great challenges of postsurgical tumor recurrence and extensive bone defect. To address these issues, innovative multifunctional PLGA/Mg porous scaffolds were designed for comprehensive postsurgical management of OS. The PLGA/Mg composite scaffolds exhibited several unique features: (1) The multiple functions of Mg particles were explored for the first time to fulfill the requirement for postsurgical management of OS. The intact Mg particles exhibits excellent photothermal effect for tumor eradication, and the released Mg ions could subsequently promote bone regeneration, thus endowing the PLGA/Mg scaffolds dual functions of suppressing OS recurrence and repairing bone defect in a sequential way; (2) A low temperature rapid prototyping (LT-RP) 3D-printing technology was used to fabricate the scaffolds with biomimetic hierarchical porous structures, which could structurally promote bone regeneration; (3) The PLGA/Mg scaffolds have excellent biodegradability and biocompatibility, exhibiting great promise for clinical translation. Finally, the PLGA/Mg scaffolds achieved complete suppression of tumor recurrence in the presence of near-infrared laser irradiation, as well as efficient bone defect repair in vivo. Activation of the AKT and ß-catenin pathways of osteoblast cells by PLGA/Mg scaffolds was identified, which might be the modulators to accelerate the ossification. The innovative PLGA/Mg scaffolds demonstrated excellent capabilities in postsurgical OS recurrence suppression and bone regeneration, providing a promising clinical strategy for comprehensive postsurgical management of OS.


Assuntos
Neoplasias Ósseas , Osteossarcoma , Neoplasias Ósseas/cirurgia , Regeneração Óssea , Humanos , Magnésio , Recidiva Local de Neoplasia , Osteogênese , Osteossarcoma/cirurgia , Impressão Tridimensional , Tecidos Suporte
13.
ACS Appl Mater Interfaces ; 13(26): 30797-30805, 2021 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-34169714

RESUMO

The memristor is a foundational device for an artificial synapse, which is essential to realize next-generation neuromorphic computing. Herein, an optoelectronic memristor based on a two-dimensional (2D) transitional-metal trichalcogenide (TMTC) is designed and demonstrated. Owing to the excellent optical and electrical characteristics of titanium trisulfide (TiS3), the memristor exhibits stable bipolar resistance switching (RS) as a result of the controllable formation and rupturing of the conductive aluminum filaments. Multilevel storage is realized with light of multiple wavelengths between 400 and 808 nm, and the synaptic properties such as conduction modulation and spiking timing-dependent plasticity (STDP) are achieved. On the basis of the photonic potentiation and electrical habitual ability, Pavlovian-associative learning is successfully established on this TiS3-based artificial synapse. All these results reveal the large potential of 2D TMTCs in artificial neuromorphic chips.

14.
Nanoscale ; 13(22): 10133-10142, 2021 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-34060584

RESUMO

Efficient point-of-care diagnosis of severe acute respiratory syndrome-corovavirus-2 (SARS-CoV-2) is crucial for the early control of novel coronavirus infections. At present, polymerase chain reaction (PCR) is primarily used to detect SARS-CoV-2. Despite the high sensitivity, the PCR process is time-consuming and complex which limits its applicability for rapid testing of large-scale outbreaks. Here, we propose a rapid and easy-to-implement approach for SARS-CoV-2 detection based on surface enhanced infrared absorption (SEIRA) spectroscopy. The evaporated gold nano-island films are used as SEIRA substrates which are functionalized with the single-stranded DNA probes for specific binding to selected SARS-CoV-2 genomic sequences. The infrared absorption spectra are analyzed using the principal component analysis method to identify the key characteristic differences between infected and control samples. The SEIRA-based biosensor demonstrates rapid detection of SARS-CoV-2, completing the detection of 1 µM viral nucleic acids within less than 5 min without any amplification. When combined with the recombinase polymerase amplification treatment, the detection capability of 2.98 copies per µL (5 aM) can be completed within 30 min. This approach provides a simple and economical alternative for COVID-19 diagnosis, which can be potentially useful in monitoring and controlling future pandemics in a timely manner.


Assuntos
COVID-19 , Ácidos Nucleicos , Teste para COVID-19 , Humanos , Técnicas de Amplificação de Ácido Nucleico , RNA Viral , SARS-CoV-2 , Sensibilidade e Especificidade , Análise Espectral
15.
Biomaterials ; 273: 120788, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33933912

RESUMO

Intrinsic immune behaviors of nanomaterials and immune systems promote research on their adjuvanticity and the design of next generation nanovaccine-based immunotherapies. Herein, we report a promising multifunctional nanoadjuvant by exploring the immune-potentiating effects of black phosphorus nanosheets (BPs) in vitro and in vivo. The facile coating of BPs with phenylalanine-lysine-phenylalanine (FKF) tripeptide-modified antigen epitopes (FKF-OVAp@BP) enables the generation of a minimalized nanovaccine by integrating high loading capacity, efficient drug delivery, comprehensive dendritic cell (DC) activation, and biocompatibility for cancer immunotherapy. Systemic immunization elicits potent antitumor cellular immunity and significantly augments checkpoint blockade (CPB) against melanoma in a mouse model. Furthermore, near-infrared (NIR) photothermal effects of BPs create an immune-favorable microenvironment for improved local immunization. This study offers new insight into the integration of immunoactivity and photothermal effects for enhanced cancer immunotherapy by using a nanoadjuvant and thus potentially advances the design and application of multifunctional adjuvant materials for cancer nanotreatment.


Assuntos
Imunoterapia , Fósforo , Adjuvantes Imunológicos , Animais , Sistemas de Liberação de Medicamentos , Fatores Imunológicos , Camundongos
16.
BMC Med Genomics ; 14(1): 126, 2021 05 10.
Artigo em Inglês | MEDLINE | ID: mdl-33971873

RESUMO

BACKGROUND: Primary bilateral macronodular adrenocortical hyperplasia (PBMAH) is a rare form of adrenal Cushing's syndrome. The slowly progressing expansion of bilateral adrenal tissues usually persists for dozens of years, leading to delayed onset with severe conditions due to chronic mild hypercortisolism. About 20-50% cases were found to be caused by inactivating mutation of armadillo repeat-containing protein 5 (ARMC5) gene. CASE PRESENTATION: A 51-year-old man was admitted for severe diabetes mellitus, resistant hypertension, centripedal obesity and edema. PBMAH was diagnosed after determination of adrenocorticotropic hormone and cortisol levels, dexamethasone suppression tests and abdominal contrast-enhanced CT scanning. The metabolic disorders of the patient remarkably improved after sequentially bilateral laparoscopic adrenalectomy combined with hormone replacement. Sanger sequencing showed germline nonsense mutation of ARMC5 c.967C>T (p.Gln323Ter). The second somatic missense mutation of ARMC5 was detected in one out of two resected nodules, reflecting the second-hit model of tumorigenesis. Routine genetic testing in his apparently healthy offspring showed one of two daughters and one son harbored the germline mutation. CONCLUSIONS: In conclusion, our case report highlight the importance of genetic testing in the molecular diagnosis of PBMAH. Genetic screening in related family members will find out asymptomatic variant carriers to guide life-long follow-up.

17.
Front Mol Biosci ; 8: 669361, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34026842

RESUMO

Fluorescent imaging combined with atomic force microscopy (AFM), namely AFM-fluorescence correlative microscopy, is a popular technology in life science. However, the influence of involved fluorophores on obtained mechanical information is normally underestimated, and such subtle changes are still challenging to detect. Herein, we combined AFM with laser light excitation to perform a mechanical quantitative analysis of a model membrane system labeled with a commonly used fluorophore. Mechanical quantification was additionally validated by finite element simulations. Upon staining, we noticed fluorophores forming a diffuse weakly organized overlayer on phospholipid supported membrane, easily detected by AFM mechanics. The laser was found to cause a degradation of mechanical stability of the membrane synergically with presence of fluorophore. In particular, a 30 min laser irradiation, with intensity similar to that in typical confocal scanning microscopy experiment, was found to result in a ∼40% decrease in the breakthrough force of the stained phospholipid bilayer along with a ∼30% reduction in its apparent elastic modulus. The findings highlight the significance of analytical power provided by AFM, which will allow us to "see" the "unseen" in correlative microscopy, as well as the necessity to consider photothermal effects when using fluorescent dyes to investigate, for example, the deformability and permeability of phospholipid membranes.

18.
Chem Soc Rev ; 50(6): 3656-3676, 2021 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-33710177

RESUMO

The novel human infectious coronaviruses (CoVs) responsible for severe respiratory syndromes have raised concerns owing to the global public health emergencies they have caused repeatedly over the past two decades. However, the ongoing coronavirus disease 2019 (COVID-19) pandemic induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has received unprecedented attention internationally. Monitoring pathogenic CoVs in environmental compartments has been proposed as a promising strategy in preventing the environmental spread and tracing of infectious diseases, but a lack of reliable and efficient detection techniques is still a significant challenge. Moreover, the lack of information regarding the monitoring methodology may pose a barrier to primary researchers. Here, we provide a systematic introduction focused on the detection of CoVs in various environmental matrices, comprehensively involving methods and techniques of sampling, pretreatment, and analysis. Furthermore, the review addresses the challenges and potential improvements in virus detection techniques for environmental surveillance.


Assuntos
Teste para COVID-19/métodos , COVID-19/diagnóstico , COVID-19/epidemiologia , Monitoramento Ambiental/métodos , Pandemias , SARS-CoV-2/isolamento & purificação , Aerossóis/análise , COVID-19/transmissão , Fômites/virologia , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Imunoensaio , Controle de Qualidade , SARS-CoV-2/genética , SARS-CoV-2/imunologia , Esgotos/virologia , Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz , Águas Residuárias/virologia
19.
Biomed Environ Sci ; 34(1): 9-18, 2021 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-33531103

RESUMO

Objective: The relationship between serum uric acid (SUA) levels and glycemic indices, including plasma glucose (FPG), 2-hour postload glucose (2h-PG), and glycated hemoglobin (HbA1c), remains inconclusive. We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population. Methods: The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study. A total of 105,922 community-dwelling adults aged ≥ 40 years underwent the oral glucose tolerance test and uric acid assessment. The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models. Results: A total of 30,941 men and 62,361 women were eligible for the current analysis. Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels, but with different inflection points in men and women. The thresholds for FPG, 2h-PG, and HbA1c for men and women were 6.5/8.0 mmol/L, 11.0/14.0 mmol/L, and 6.1/6.5, respectively (SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices). Conclusion: An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes, while the inflection points were reached earlier in men than in women.


Assuntos
Índice Glicêmico , Ácido Úrico/sangue , Idoso , Glicemia/análise , China/epidemiologia , Estudos de Coortes , Diabetes Mellitus/sangue , Feminino , Teste de Tolerância a Glucose , Hemoglobina A Glicada/análise , Humanos , Masculino , Pessoa de Meia-Idade
20.
Nanoscale ; 13(1): 51-58, 2021 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-33326544

RESUMO

New electrode materials are crucial to high-performance lithium-ion batteries (LIBs). Silicon monophosphides (SiPs), composed of silicon and phosphorus, have a very high theoretical capacity (3060 mA h g-1), which is more than 8 times that of graphite (372 mA h g-1). The two-dimensional structure of SiPs also benefits ion transportation and diffusion. In this work, the chemical vapor transport (CVT) method is employed to synthesize SiPs for LIB anodes, and the lithium storage capacity co-affected by size and crystallinity is investigated using controllably synthesized thin belts and bulk crystals. The SiPs prepared by the high-temperature iodine-assisted CVT method have a belt-like morphology about 72 nm thick. After 200 cycles, the stable capacity is about 615 mA h g-1 at 100 mA g-1, and a reversible capacity of ∼320 mA h g-1 is achieved at a high current density of 5.0 A g-1. In contrast, the micrometer-thick bulk SiP crystals cannot provide efficient lithium ion extraction. Moreover, the smaller and thinner SiPs obtained at a lower temperature show abnormally high mass transport resistance and low lithium ion diffusivity. These results demonstrate that SiPs are promising LIB anode materials, and the size and crystallinity are closely related to the anodic performance. This new knowledge is valuable for the development of high-performance LIBs.

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