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Rev Sci Instrum ; 89(10): 106102, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30399692


The ability to conduct en-route centrifugation of samples improves quality and timeliness in the pre-analytical phase. This is demonstrated here on a quadcopter whereby the propellers were adapted to house and apply centrifugal forces to sample-containing capillary tubes instead of incorporating a centrifuge. Tests revealed the ability of the method to separate non-homogenized milk into a cream portion and a skim milk portion, and human whole blood into plasma, buffy coat, and red blood cell components.

Anal Biochem ; 545: 1-3, 2018 03 15.
Artigo em Inglês | MEDLINE | ID: mdl-29307634


Autonomous systems for sample transport to the laboratory for analysis can be improved in terms of timeliness, cost and error mitigation in the pre-analytical testing phase. Drones have been reported for outdoor sample transport but incorporating devices on them to attain homogenous mixing of reagents during flight to enhance sample processing timeliness is limited by payload issues. It is shown here that flipping maneuvers conducted with quadcopters are able to facilitate complete and gentle mixing. This capability incorporated during automated sample transport serves to address an important factor contributing to pre-analytical variability which ultimately impacts on test result reliability.

Testes Imediatos , Impressão Tridimensional , Biomarcadores/análise , Humanos , Testes Imediatos/economia , Impressão Tridimensional/economia , Impressão Tridimensional/instrumentação
Eur Phys J E Soft Matter ; 38(11): 119, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26577818


We advance a scheme in which a liquid body on a stationary tip in contact with a rotating superhydrophobic surface is able to maintain resonance primarily from stick-slip events. With tip-to-surface spacing in the range 2.73 ≤ h < 2.45 mm for a volume of 10 µL, the liquid body was found to exhibit resonance independent of the speed of the drum. The mechanics were found to be due to a surface-tension-controlled vibration mode based on the natural frequency values determined. With spacing in the range 2.45 ≤ h < 2.15 mm imposed for a volume of 10 µL, the contact length of the liquid body was found to vary with rotation of the SH drum. This was due to the stick-slip events being able to generate higher energy fluctuations causing the liquid-solid contact areas to vary since the almost oblate spheroid shape of the liquid body had intrinsically higher surface energies. This resulted in the natural frequency perturbations being frequency- and amplitude-modulated over a lower frequency carrier. These findings have positive implications for microfluidic sensing.

Microfluídica , Nanoestruturas/química , Interações Hidrofóbicas e Hidrofílicas , Rotação , Propriedades de Superfície
Langmuir ; 31(24): 6695-703, 2015 Jun 23.
Artigo em Inglês | MEDLINE | ID: mdl-25986160


Captive bubbles on a superhydrophobic (SH) surface have been shown to increase in volume via injection of air through the surrounding plastron. The experimental contact diameter against volume trends were found to follow that predicted by the Surface Evolver simulation generally but corresponded with the simulated data at contact angle (CA) = 158° when the volume was 20 µL but that at CA = 170° when the volume was increased to 180 µL. In this regime, there was a simultaneous outward movement of the contact line as well as a small reduction in the slope that the liquid-air interface makes with the horizontal as air was injected. At volumes higher than 180 µL, air injection caused the diameter to reduce progressively until detachment. The inward movement of the contact line in this regime allowed the bubble body to undergo shape deformations to stay attached onto the substrate with larger volumes (300 µL) than predicted (220 µL at CA = 170°) using simulation. In experiments to investigate the effect of translating the SH surface, movement of captive bubbles was possible with 280 µL volume but not with 80 µL volume. This pointed to the possibility of transporting gas-phase samples on SH surfaces using larger captive bubble volumes.

J Pharm Biomed Anal ; 102: 199-202, 2015 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25289516


Array-based tests in a microplate format are complicated by the regional variation in results of the outer against the inner wells of the plate. Analysis of the evaporation mechanics of sessile drops showed that evaporation rate increase with temperature was due to changes in the heat of vaporization, density and diffusion coefficient. In simulations of direct bottom heating of standard microplates, considerable heat transfer via conduction from the side walls was found to be responsible for lower temperatures in the liquid in wells close to the edge. Applying a two temperature heating mode, 304 K at the side compared to 310 K at the bottom, allowed for a more uniform temperature distribution. Transparency microplates were found to inherently possess immunity to the edge effect problem due to the presence of air between the liquid and solid wall.

Testes de Química Clínica/métodos , Análise de Elementos Finitos , Temperatura Alta , Humanos , Volatilização