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1.
Sci Total Environ ; 807(Pt 1): 150561, 2021 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-34624692

RESUMO

Hydroxylated polybrominated diphenyl ethers (OH-BDEs) are major transformation products of PBDEs that readily bioaccumulate in the marine food web. Although 6-OH-BDE-47 is frequently and abundantly detected in cetaceans, its potential toxic effects are largely unknown. We explored the toxicological pathways and mechanisms of OH-BDEs by exposing pygmy killer whale skin fibroblast cell lines (PKW-LWHT) to 6-OH-BDE-47 at concentrations ranging from 0.02, 0.2, 2 to 4 µM. The result showed that 6-OH-BDE-47 inhibited cell proliferation in a concentration- and time-dependent manner. The cell cycle data revealed that the cell cycle was arrest at the G0/G1 phase by 6-OH-BDE-47. Using qPCR and Western blot assay, we found that 6-OH-BDE-47 up-regulated the transcription and expression level of p21 and RB1 and down-regulated the expression level of Proliferating Cell Nuclear Antigen (PCNA), CDK2, CDK4, cyclin D1, cyclin E2, E2F1, and E2F3 and the cellular phosphorylated RB1. The results showed that 6-OH-BDE-47 was able to arrest the cell cycle of PKW-LWHT cells at G1 phase by changing the expression level of related regulatory genes in G1 stage, and finally inhibit cell proliferation.

2.
Artigo em Inglês | MEDLINE | ID: mdl-34477493

RESUMO

Chloropropanols such as 3-monochloropropane-1,2-diol (3-MCPD) and 1,3-dichloro-2-propanol (1,3-DCP) have drawn increasing attention due to their release from food contact paper and their potential carcinogenic effects. In this study, the effects were investigated of water extraction conditions on release of chloropropanols from food contact paper, and the extraction efficiencies of chloropropanols by water extract and migration method were compared. Cold water was found to be more severe than hot water for extraction of chloropropanols, with the highest water extraction value obtained at 23°C. Two hours of extraction was sufficient as the chloropropanols can be fully extracted from food contact paper within a short period of time. Increase of temperature in the range of 10°C-60°C had little impact on release of chloropropanols, however, the extraction of chloropropanols decreased when high temperatures (80°C or above) were applied due to volatilisation losses. Hence, attention should be paid when choosing extract conditions representing the worst-case scenario. The water extraction value using EN 645 method gives higher results compared to migration test described in GB 31604.1 and GB 5009.156, suggesting that the water extract method was probably more severe. For migration test, aqueous-based simulants were found to be more conservative than oil-based simulants, suggesting the conventional experiment conditions applicable for compliance test of chloropropanols migration can be simplified and optimised.

3.
Artigo em Inglês | MEDLINE | ID: mdl-34549872

RESUMO

Therapeutic peptides have been widely concerned because of their good biocompatibility, but their efficacy is limited by the inability to penetrate cell membranes, which is a key bottleneck in peptide drugs delivery. Herein, an in vivo self-assembly strategy is developed to induce phase separation of cell membrane that improves the peptide drugs internalization and anticancer efficacy. A phosphopeptide KYp is synthesized, containing an anticancer peptide [KLAKLAK] 2 (K) and a responsive moiety phosphorylated Y (Yp). After interacting with alkaline phosphatase (ALP) on the cell membrane, KYp can be dephosphorylated and self-assembles in situ , which induces the aggregation of ALP and the protein-lipid phase separation on the cell membrane. ALP is involved in the assembly of peptides, forming the large aggregates and entering cells, which leads to the enhanced permeability of cell membrane. Consequently, the peptide drugs internalization is ~2-fold enhanced compared to non-responsive peptide nanoparticle, and IC 50 value of KYp is approximately ~5 times lower than that of free peptide. Finally, the tumor of mice treated with KYp is suppressed effectively, showing the negligible side effect in vivo . Therefore, the in vivo self-assembly induced phase separation on the cell membrane promises a new strategy to improve the drug delivery efficacy in cancer therapy.

4.
Nature ; 596(7872): 362-366, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34408329

RESUMO

Polaritons in anisotropic materials result in exotic optical features, which can provide opportunities to control light at the nanoscale1-10. So far these polaritons have been limited to two classes: bulk polaritons, which propagate inside a material, and surface polaritons, which decay exponentially away from an interface. Here we report a near-field observation of ghost phonon polaritons, which propagate with in-plane hyperbolic dispersion on the surface of a polar uniaxial crystal and, at the same time, exhibit oblique wavefronts in the bulk. Ghost polaritons are an atypical non-uniform surface wave solution of Maxwell's equations, arising at the surface of uniaxial materials in which the optic axis is slanted with respect to the interface. They exhibit an unusual bi-state nature, being both propagating (phase-progressing) and evanescent (decaying) within the crystal bulk, in contrast to conventional surface waves that are purely evanescent away from the interface. Our real-space near-field imaging experiments reveal long-distance (over 20 micrometres), ray-like propagation of deeply subwavelength ghost polaritons across the surface, verifying long-range, directional and diffraction-less polariton propagation. At the same time, we show that control of the out-of-plane angle of the optic axis enables hyperbolic-to-elliptic topological transitions at fixed frequency, providing a route to tailor the band diagram topology of surface polariton waves. Our results demonstrate a polaritonic wave phenomenon with unique opportunities to tailor nanoscale light in natural anisotropic crystals.

5.
Environ Pollut ; 288: 117712, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34246996

RESUMO

Nitrate, as one of the major components of tropospheric aerosols, plays a crucial role in winter haze formation. While, the formation mechanism of the high production of nitrate in Chinese megacities is still not fully understood. To quantify the contributions of major formation pathways to nitrate, airborne particles in Xi'an, inland China during the winter of 2017 were measured and analyzed for the water-soluble ions and stable nitrogen/oxygen isotope compositions of nitrate in PM2.5, followed by a WRF-Chem model simulation. The oxygen isotopic results indicated that N2O5 hydrolysis was an important formation pathway for the daytime nitrate in the haze episodes. The model simulation further revealed that N2O5 hydrolysis contribution increased from 8.2% to 20.5% of the total nitrate over 14:00-16:00 p.m., clearly showing that N2O5 formation followed by a heterogeneous hydrolysis to nitrate can effectively proceed in daytime under the abundantly co-existing O3, NO2 and NH3 conditions.


Assuntos
Poluentes Atmosféricos , Nitratos , Aerossóis/análise , Poluentes Atmosféricos/análise , China , Monitoramento Ambiental , Hidrólise , Nitratos/análise , Material Particulado/análise , Estações do Ano
6.
Biomed J ; 2021 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-34237455

RESUMO

The natriuretic peptide family (NPs) is a group of natural endocrine hormones, containing a 17-amino acid ring structure connected by disulfide bonds of two cysteines. In this review, the members of the natriuretic peptide family and their corresponding receptors as well as the anti-cancer effects are introduced. Four cardiac hormones of NPs (ANP, VD, KP and LANP) can effectively inhibit the growth of human small cell lung cancer, breast cancer and other tumors and significantly reduce tumor volume in vivo. The in vitro experiments also show that cardiac hormones, CNP and urodilatin can effectively inhibit the growth of most tumor cells. We then further summarized the anti-cancer mechanism of natriuretic peptides. Finally, we will introduce several methods that modify natriuretic peptides, leading to enhance their stability and prolong the biological effects of these peptides, which might be helpful for the clinical application in the future. Peptide therapy is a very promising field for cancer treatments since they can induce the death of cancer cells without dramatically affecting normal cells. The synthesis of a useful and stable natriuretic peptide can enhance the effect of cancer treatments and significantly reduce drug resistance and toxicity.

7.
Chem Commun (Camb) ; 2021 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-34213519

RESUMO

By utilizing a supramolecular complex rather than an individual molecule as a deformable and elastic substitutional component, we put forward a solid-solution strategy and demonstrate an example of how two related yet non-isostructural crystalline host-guest compounds can form molecular solid solutions. Interestingly, such a strategy can effectively and continuously modulate the molecular motion and phase transition in them, as revealed by the variable-temperature/frequency dielectric responses.

8.
Comput Intell Neurosci ; 2021: 5582666, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34257637

RESUMO

Emotion plays an important role in people's life. However, the existing researches do not give a unified conclusion on the brain function network under different emotional states. In this study, pictures from the international affective picture system (IAPS) of different valences were presented to subjects with a fixed frequency blinking frequency to induce stable state visual evoked potential (SSVEP). With the source location method, the cerebral cortex source signal was reconstructed based on EEG signals, and then the difference in SSVEP amplitudes in key brain areas under different emotional states and the difference in brain function network connections among different brain areas were analysed in cortical space. The results of the study show that positive and negative emotions evoked greater activation intensities in the prefrontal, temporal, and parietal lobes compared with those of neutral emotion. The network connections with a significant difference between emotional states mainly appear in the alpha and gamma bands, and the network connections with significant differences between positive emotion and negative emotion mainly exist in the right middle temporal gyrus and the superior frontal gyrus on both sides. In addition, the long-range connections play an important role in the process of emotional processing, especially the connections among frontal gyrus, middle temporal gyrus, and middle occipital gyrus. The results of this study provide a reliable scientific basis for revealing and elucidating the neural mechanism of emotion processing and the selection of brain regions and frequency bands in emotion recognition based on EEG signals.


Assuntos
Potenciais Evocados Visuais , Imageamento por Ressonância Magnética , Encéfalo , Mapeamento Encefálico , Córtex Cerebral , Emoções , Humanos
9.
BMJ Open ; 11(7): e045168, 2021 07 12.
Artigo em Inglês | MEDLINE | ID: mdl-34253663

RESUMO

OBJECTIVE: To assess the awareness, attitude and barriers of colorectal cancer screening among high-risk populations in China. DESIGN: A cross-sectional study was employed. SETTING: This study was conducted in nine hospitals in Hunan province, China. PARTICIPANTS: Individuals with a high-risk for colorectal cancer were interviewed using a pretested structured questionnaire. PRIMARY AND SECONDARY OUTCOME MEASURES: Knowledge, attitude towards colorectal cancer screening, sociodemographic factors associated with screening knowledge and behaviour and barriers of colorectal cancer screening. RESULTS: This study included 684 participants. The mean knowledge score was 11.86/24 (SD 4.84). But over 70% of them held a positive attitude towards screening. Only 13.3% had undergone colorectal cancer screening. Independent factors related to knowledge were education level of college or above, working as a white collar, higher income, having health insurance, having seen a doctor in the past year and with a high perceived risk (p<0.05). Factors independently associated with screening behaviour included personal history of colorectal disease, having seen a doctor in the past year, previous discussion of colorectal cancer screening, high perceived risk and better knowledge (p<0.05). Main reasons for not undergoing screening were no symptoms or discomfort (71.1%), never having thought of the disease or screening (67.4%) and no doctor advised me (29.8%). CONCLUSION: In China, the majority of high-risk people had deficient knowledge and had never undergone colorectal cancer screening. But most of them held a positive attitude towards the benefits of colorectal cancer screening. This has promising implications to design targeted educational campaigns and establish screening programmes to improve colorectal cancer awareness and screening participation. Healthcare professionals should advise high-risk individuals to participate in screening and inform them about cancer risk.


Assuntos
Neoplasias Colorretais , Detecção Precoce de Câncer , China , Neoplasias Colorretais/diagnóstico , Estudos Transversais , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Programas de Rastreamento , Fatores de Risco , Inquéritos e Questionários
11.
AIDS Rev ; 23(3): 153-163, 2021 06 03.
Artigo em Inglês | MEDLINE | ID: mdl-34082440

RESUMO

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious RNA coronavirus responsible for the pandemic of the coronavirus disease 2019 (COVID-19). Recent advances in virology, epidemiology, diagnosis, and clinical management of COVID-19 have contributed to the control and prevention of this disease, but re-positivity of SARS-CoV-2 in recovered COVID-19 patients has brought a new challenge for this worldwide anti-viral battle. Reverse transcription polymerase chain reaction (RT-PCR) tests of the SARS-CoV-2 pathogen is widely used in clinical diagnosis, but a positive RT-PCR result may be multifactorial, including false positive, SARS-CoV-2 RNA fragment shedding, reinfection of SARS-CoV-2, or re-activation of COVID-19. Re-infection of SARS-CoV-2 or re-activation of COVID-19 is an indicator of live viral carriers and isolation/treatment is needed, but SARS-CoV-2 RNA fragment shedding is not. SARS-CoV-2 RNA is recently reported to integrate into the host genome, but the far-reaching outcome is currently unclear. Therefore, it is critical for appropriate manipulation and prevention of COVID-19 to distinguish these causal factors of SARS-CoV-2 re-positivity. In this review article, we updated the current knowledge of SARS-CoV-2 re-positivity in discharged COVID-19 patients with a focus on re-infection and re-activation. We proposed a hypothetical flowchart for handling of the SARS-CoV-2 re-positive cases.


Assuntos
COVID-19/patologia , RNA Viral/análise , Reinfecção/virologia , SARS-CoV-2/genética , Ativação Viral/genética , Imunidade Adaptativa/imunologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Anticorpos Antivirais/sangue , COVID-19/diagnóstico , Criança , Pré-Escolar , Reações Falso-Positivas , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Adulto Jovem
12.
Ren Fail ; 43(1): 993-1003, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34157941

RESUMO

OBJECTIVES: Concerns are increasing about the clinical characteristics of gram- negative bacterial peritonitis for providing reference for clinical diagnosis, treatment and prevention. METHODS: A retrospective analysis was performed examining patients who developed peritoneal dialysis-related peritonitis (PDRP) from 1 January 2009 to 31 December 2018. RESULTS: Among 898 PD patients, 677 episodes of peritonitis occurred in 344 patients. Over 10 years, the proportion of gram-negative bacterial peritonitis increased from 0% to 26.15% (p = .045). E. coli was the leading cause (38.51%) of the 148 cases of gram-negative bacterial peritonitis. The increase of E. coli peritonitis between the first 5 and the last 5 years was obvious (20.45% vs. 46.15%). The antimicrobial sensitivity of gram-negative organisms to cefotaxime decreased from 71.43% to 55.84% (p = .017). In the gram-negative group, the effluent white cell count (WCC) on the first day was larger (OR: 1.374;95%CI: 1.248-1.563; p < .001), the time required for the WCC to normalize was longer (OR: 1.100;95%CI: 1.037-1.189; p = .003), and the level of C-reactive protein (CRP) was higher (OR: 1.038;95%CI: 1.026-1.042; p < .001) than those in the gram-positive group. The complete cure rate and treatment failure rate of gram-negative bacteria peritonitis were 87.8% and 12.2% respectively. CONCLUSIONS: Over 10 years, the proportion of gram-negative bacterial peritonitis increased, with E. coli epidermidis being the most common pathogen. More effluent WCC on the first day, longer time required for the WCC to normalize, and higher level of CRP are more common for gram-negative bacterial peritonitis. Prognosis of gram-negative bacterial peritonitis is worse.

13.
Electrophoresis ; 42(16): 1578-1593, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34018209

RESUMO

The Y-STR landscape of Coastal Southeastern Han (CSEH) living in Chinese southeast areas (including Guangdong, Fujian, and Zhejiang provinces) is still unclear. We investigated 62 Y-STR markers in a reasonably large number of 1021 unrelated males and 1027 DNA-confirmed father-son pairs to broaden the genetic backgrounds of CSEH. In total, 85 null alleles, 121 off-ladder alleles, and 95 copy number variants were observed, and 1012 distinct haplotypes were determined with the overall HD and DC values of 0.999974 and 0.9912. We observed 369 mutations in 76 099 meiotic transfers, and the average estimated Y-STR mutation rate was 4.85 × 10-3 (95% CI, 4.4 × 10-3 -5.4 × 10-3 ). The Spearman correlation analyses indicated that GD values (R2 = 0.6548) and average allele sizes (R2 = 0.5989) have positive correlations with Y-STR mutation rates. Our RM Y-STR set including 8 candidate RM Y-STRs, of which DYS534, DYS630, and DYS713 are new candidates in CSEH, distinguished 18.52% of father-son pairs. This study also clarified the population structures of CSEH which isolated in population-mixed South China relatively. The strategy, SM Y-STRs for familial searching and RM Y-STRs for individual identification regionally, could be applicable based on enough knowledge of the Y-STR mutability of different populations.

14.
Angew Chem Int Ed Engl ; 60(29): 16215-16223, 2021 07 12.
Artigo em Inglês | MEDLINE | ID: mdl-33971079

RESUMO

The systemic use of pharmaceutical drugs for cancer patients is a compromise between desirable therapy and side effects because of the intrinsic shortage of organ-specific pharmaceutical drug. Design and construction of pharmaceutical drug to achieve the organ-specific delivery is thus desperately desirable. We herein regulate perylene skeleton to effect organ-specificity and present an example of lung-specific distribution on the basis of bay-twisted PDIC-NC. We further demonstrate that PDIC-NC can target into mitochondria to act as cellular respiration inhibitor, inducing insufficient production of adenosine triphosphate, promoting endogenous H2 O2 and . OH burst, elevating calcium overload, efficiently triggering the synergistic apoptosis, autophagy and endoplasmic reticulum stress of lung cancer cells. The antitumor performance of PDIC-NC is verified on in vivo xenografted, metastasis and orthotopic lung cancer, presenting overwhelming evidences for potentially clinical application. This study contributes a proof-of-concept demonstration of twisted perylene to well attain lung-specific distribution, and meanwhile achieves intensive lung cancer chemotherapy.


Assuntos
Antineoplásicos/química , Antineoplásicos/farmacologia , Perileno/química , Perileno/farmacologia , Apoptose/efeitos dos fármacos , Autofagia/efeitos dos fármacos , Linhagem Celular Tumoral , Estresse do Retículo Endoplasmático/efeitos dos fármacos , Humanos , Relação Estrutura-Atividade
15.
ACS Nano ; 15(5): 8694-8705, 2021 05 25.
Artigo em Inglês | MEDLINE | ID: mdl-33957753

RESUMO

Photodynamic therapy (PDT) has shown great potential in infection treatment. However, the shallow depth of the short wavelength light and the low reactive oxygen species (ROS) production hinder its development. A strategy that can achieve a second near-infrared (NIR-II) light that is a long wavelength induced multi-intensified antibacterial PDT is most critical. Herein, hybrid plasmonic Au/CdSexSy with precise Ag doping (ACA) nanodumbbells are rationally designed for ideal NIR-II light induced antibacterial PDT. Plasmonic Au nanorods extend the photocatalytic activity of ACA to NIR-II regions, which provides a basis for NIR-II light induced PDT. More importantly, multi-intensified PDT can be realized by the following creativities: (i) elaborate design of as-synthesized nanodumbbells that allows for electron holes to be redistributed in different regions simultaneously, (ii) the efficient hot-electrons injection that benefits from the ratio tailoring of anions ratio of Se and S, and (iii) the dopant Ag level inhibiting the combination of electron holes. The nanodumbbells create effective hot-electrons injection and a separation of electron holes, which provides great convenience for the production of ROS and allows NIR-II light induced PDT for the inhibition of bacteria and biofilms. As a result, comparably, our well-defined ACA hybrid nanodumbbells can generate about 40-fold superoxide radicals (·O2-) and more hydroxyl radicals (·OH). Therefore, the MIC value of the as-synthesized nanodumbbells is lower than the value of 1/16 of core-shell ACA. In vivo results further demonstrate that our nanodumbbells exhibit excellent PDT efficacy.


Assuntos
Nanotubos , Fotoquimioterapia , Fármacos Fotossensibilizantes/farmacologia , Fármacos Fotossensibilizantes/uso terapêutico , Espécies Reativas de Oxigênio
16.
Drug Des Devel Ther ; 15: 1915-1930, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33976541

RESUMO

Background: S. baicalensis, a traditional herb, has great potential in treating diseases associated with aberrant lipid metabolism, such as inflammation, hyperlipidemia, atherosclerosis and Alzheimer's disease. Aim of the Study: To elucidate the mechanism by which S. baicalensis modulates lipid metabolism and explore the medicinal effects of S. baicalensis at a holistic level. Materials and Methods: The potential active ingredients of S. baicalensis and targets involved in regulating lipid metabolism were identified using a network pharmacology approach. Metabolomics was utilized to compare lipids that were altered after S. baicalensis treatment in order to identify significantly altered metabolites, and crucial targets and compounds were validated by molecular docking. Results: Steroid biosynthesis, sphingolipid metabolism, the PPAR signaling pathway and glycerolipid metabolism were enriched and predicted to be potential pathways upon which S. baicalensis acts. Further metabolomics assays revealed 14 significantly different metabolites were identified as lipid metabolism-associated elements. After the pathway enrichment analysis of the metabolites, cholesterol metabolism and sphingolipid metabolism were identified as the most relevant pathways. Based on the results of the pathway analysis, sphingolipid and cholesterol biosynthesis and glycerophospholipid metabolism were regarded as key pathways in which S. baicalensis is involved to regulate lipid metabolism. Conclusion: According to our metabolomics results, S. baicalensis may exert its therapeutic effects by regulating the cholesterol biosynthesis and sphingolipid metabolism pathways. Upon further analysis of the altered metabolites in certain pathways, agents downstream of squalene were significantly upregulated; however, the substrate of SQLE was surprisingly increased. By combining evidence from molecular docking, we speculated that baicalin, a major ingredient of S. baicalensis, may suppress cholesterol biosynthesis by inhibiting SQLE and LSS, which are important enzymes in the cholesterol biosynthesis pathway. In summary, this study provides new insights into the therapeutic effects of S. baicalensis on lipid metabolism using network pharmacology and lipidomics.

17.
J Med Virol ; 93(8): 4966-4974, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-33913556

RESUMO

This study aimed to examine changes in levels of cytokine and T cell surface molecules in chronic hepatitis B (CHB) patients receiving sequential interferon therapy following 1-year nucleos(t)ide analogs (NAs) treatment. Cytokine levels were measured in 30 patients, and T cell surface molecule expression was measured in 48 patients receiving sequential interferon therapy and 24 patients only receiving NA mono-therapy. An HBsAg titer of <0.05 IU/ml was defined as a "functional cure." In the cured group (HBsAg < 0.05 IU/ml), a decreasing probability was observed in IFN-γ (after Week 0), and IL-22 and IP-10 (after Week 12). In the non-cured group (HBsAg ≥ 0.05 IU/ml), a probability of slightly decreasing was observed for IFN-γ (after Week 12), and a probability of increasing IP-10 concentration (after Week 0) was observed. Generalized estimating equation (GEE) analyses showed significant differences in the levels of IL-10, IL-23, CCL-3, IL-1ß, IL-2, and IL-12P70 between the two groups. In GEE analysis, there were significant differences in expressions of CD45RO+ between the cured group and the non-cured group. The frequencies of T cells expressing Tim-3, CD62L, and CD152 were significantly lower in the sequential interferon therapy group than in the NA mono-therapy group. Changes in cytokine levels (IFN-γ, IP-10, IL-10, IL-23, CCL-3, IL-1ß, IL-2, and IL-12P70) and T cell surface molecules (CD45RO+ ) may predict HBsAg seroconversion in CHB patients receiving sequential interferon therapy. The period from Weeks 12 to 24 during sequential interferon therapy may be a critical time of immune status change.

18.
Asian J Psychiatr ; 60: 102655, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33882386

RESUMO

Broad Autism Phenotype (BAP) refers to a set of symptoms or personality traits which similar but not meet the diagnostic criteria for autism in relatives of individuals with Autism Spetrum Disorders (ASD).The Broad Autism Phenotype Questionnaire (BAPQ) is one of the new and widely used assessment tools to measure BAP.It has been translated into 8 different languages and some versions were investigated the psychometric properties but not including Chinese version (BAPQ-C).This study aimed to analyze the reliability and validity of the BAPQ-C and explore its applicability in the Chinese population. 1,618 families were included in the study consisting of 890 ASD children and 728 typically developed(TD)children. Our results did not find a well-fitting three-factor(Aloof,Rigid,Pragmatic language) structure which is consistent with previous studies.But we formed a model that only included Aloof and Pragmatic language dimensions.The parameter after removing the rigid dimension was significantly better.This study indicated that the short version of Aloof and Pragmatic language sub-scales has good reliability and validity and can be used to study BAP in the Chinese population. Nevertheless, more studies are still needed to improve the psychometric properties of the BAPQ-C.


Assuntos
Transtorno do Espectro Autista , Transtorno Autístico , Transtorno do Espectro Autista/diagnóstico , Transtorno Autístico/diagnóstico , Criança , China , Humanos , Idioma , Fenótipo , Reprodutibilidade dos Testes , Inquéritos e Questionários
19.
Brain Res ; 1765: 147502, 2021 08 15.
Artigo em Inglês | MEDLINE | ID: mdl-33901488

RESUMO

In dynamic video target detection tasks, distractors may suddenly appear due to the dynamicity of the visual scene and the uncertainty of the visual information, strongly influencing participants' attention and target detection performance. Moreover, the neural mechanism that accounts for dynamic distractor processing remains unknown, which makes it difficult to compensate for in EEG-based video target detection. Here, cortical activities with high spatiotemporal resolution were reconstructed using the source localization method. The time-varying networks among important brain regions in different cognitive phases, including information integration, decision-making, and execution, were identified to investigate the neural mechanism of dynamic distractor processing. The experimental results indicated that dynamic distractors could induce a P3-like component. In addition, there was obvious asymmetry between the two hemispheres during video target detection. Specifically, the brain responses induced by dynamic distractors were weak and more concentrated in the left hemisphere during the information integration phase; left superior frontal gyrus activity related to preparation for the presence of distractors was critical, while the attention network and primary visual network, especially in the left visual pathway, were more active for dynamic targets during the decision-making phase. These findings provide guidance for designing an effective EEG-based model for dynamic video target detection.

20.
Zhongguo Zhong Yao Za Zhi ; 46(1): 41-45, 2021 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-33645049

RESUMO

Drying is one of the most common unit operations in the production of traditional Chinese medicine. The drying process of traditional Chinese medicine materials is accompanied by the dynamic reduction of water content. As a key index to determine the end of the drying process, the moisture content of materials plays an important role in improving drying efficiency and saving energy. Recently, the drying process of traditional Chinese medicine is mostly monitored by offline detection, and there are few reports of online moisture detection applications. In this paper, the principle and current application of online inspection technology for the material drying process in different fields were introduced. The significance of online detection technology in drying of traditional Chinese medicine was also analyzed. Meanwhile, the application prospect of online detection technology in the field of drying of traditional Chinese medicine was predicted. In response to urgent transformation and upgrading of the traditional Chinese medicine manufacturing industry, the application of online moisture detection technology is expected to be a key breakthrough in the intelligent upgrading of traditional Chinese medicine drying technology and equipment.


Assuntos
Medicamentos de Ervas Chinesas , Medicina Tradicional Chinesa , Dessecação , Controle de Qualidade , Tecnologia Farmacêutica
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