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1.
J Colloid Interface Sci ; 638: 99-108, 2023 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-36736122

RESUMO

Anodes based on silicon/carbon composites promise their commercial prospects for next-generation lithium ion batteries owing to their merits of high specific capacity, enhanced ionic and electronic conductivity, and excellent compatibility. Herein, a series of carbonaceous framework/Si composites are designed and prepared by rational waste utilization. N, P codoped foam-like porous carbon/Si composites (FPC@Si) and N, P codoped carbon coated Si composites (NPC@Si) are fabricated by utilizing expired milk powder as a carbon source with facile treatment methods. The results indicate that the porous carbon skeleton and carbon shell can improve the conductivity of Si and stabilize the solid electrolyte interfaces to avoid direct contact between active material and electrolyte. Moreover, the influence of drastic volume expansion of Si on the anode can be efficiently alleviated during charge/discharge processes. Therefore, the Si/C composite electrodes present excellent long-term cycling stability and rate capability. The electrochemical performance shows that the reversible capacity of FPC@Si and NPC@Si can be respectively maintained at 587.3 and 731.2 mAh g-1 after 1000 charge/discharge cycles under 400 mA g-1. Most significantly, the optimized Si/C composite electrodes exhibit outstanding performance in the full cell tests, promising them great potential for practical applications. This study not only provides a valuable guidance for recycling of waste resources, but also supports a rational design strategy of advanced composite materials for high-performance energy storage devices.

2.
Atherosclerosis ; 367: 1-7, 2023 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-36706681

RESUMO

BACKGROUND AND AIMS: Risk stratification for three-vessel coronary artery disease (3VD) remains an important clinical challenge. In this study, we utilized machine learning (ML), which can address the limitations of traditional regression-based models, to develop a novel model to assess mortality risk in patients with 3VD. METHODS: This study was based on a prospective cohort of 8943 participants with 3VD consecutively enrolled between 2004 and 2011. An ML-derived random forest model was trained and tested to predict 4-year mortality. The predictability of the model was compared with that of an established model, the Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery score II (SSII), among 3VD patients undergoing percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), and medical therapy (MT) alone. RESULTS: The all-cause mortality was 7.5% (667 patients) over the 4-year follow-up period. The correlation-based feature selection algorithm selected 18 of the 94 features to develop the ML model. In the testing dataset, the ML-derived model achieved an area under the curve of 0.81 for 4-year mortality prediction. Its predictability was significantly better than that of the SSII among patients undergoing PCI (0.80 vs. 0.70, p < 0.001) or CABG (0.80 vs. 0.67, p < 0.001). The model also outperformed the SSII in patients receiving MT alone (ML: 0.75 vs. SSII for PCI: 0.70 or SSII for CABG: 0.66, p < 0.001). CONCLUSIONS: This ML-based approach exhibited better performance in risk stratification for 3VD compared with the conventional method. Further validation studies are needed to confirm these findings.

3.
Micromachines (Basel) ; 14(1)2023 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-36677268

RESUMO

Live-cell microscopy is crucial for biomedical studies and clinical tests. The technique is, however, limited to few laboratories due to its high cost and bulky size of the necessary culture equipment. In this study, we propose a portable microfluidic-cell-culture system, which is merely 15&nbsp;cm×11&nbsp;cm×9&nbsp;cm in dimension, powered by a conventional alkali battery and costs less than USD 20. For long-term cell culture, a fresh culture medium exposed to 5% CO2 is programmed to be delivered to the culture chamber at defined time intervals. The 37 °C culture temperature is maintained by timely electrifying the ITO glass slide underneath the culture chamber. Our results demonstrate that 3T3 fibroblasts, HepG2 cells, MB-231 cells and tumor spheroids can be well-maintained for more than 48 h on top of the microscope stage and show physical characters (e.g., morphology and mobility) and growth rate on par with the commercial stage-top incubator and the widely adopted CO2 incubator. The proposed portable cell culture device is, therefore, suitable for simple live-cell studies in the lab and cell experiments in the field when samples cannot be shipped.

4.
Int Immunopharmacol ; 115: 109659, 2023 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-36608442

RESUMO

Hyperactivity of HPA axis results in intestinal dysfunction, which may play a role in brain injury caused by ischemic stroke (IS). Escin shows a neuroprotective effect but it may not penetrate blood brain barrier (BBB). Previous work in our laboratory showed that escin ameliorated intestinal injury in animals. The aim of this study is to investigate whether escin attenuates brain injury by improving intestinal dysfunction in middle cerebral artery occlusion (MCAO) rats, to mimic IS. MCAO rats and lipopolysaccharides (LPS)-induced Caco-2 cells were used to evaluate the effects of escin in vivo and in vitro. The results showed that escin could not penetrate BBB but reduced brain infarct volume, improved neurological function, inhibited neuroinflammation, ameliorated intestinal dysfunction and tissue integrity by increasing the expression of the tight junction protein in vivo and in vitro. Escin reduced the increased corticosterone and endotoxin level in blood of MCAO rats, regulated GR/p38 MAPK/NF-κB signaling pathway in ileal tissue and LPS/TLR4/NF-κB signaling pathway in ischemic brain tissue. These findings suggest that escin could attenuate ischemic brain injury by improving intestinal dysfunction, and it may be a promising way to protect brain injury by protecting intestine, instead of targeting the brain directly after IS.

5.
J Reprod Immunol ; 155: 103789, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-36603466

RESUMO

Follicular atresia was initiated with the apoptosis of granulosa cells (GCs) mostly mediated by oxidative stress (OS). Our previous studies found that the number of CD8+ T cells and proportion of CD8+/CD4+ T cells increased in the follicles of diminished ovary reserve (DOR). However, the mechanism was still poorly explored. Herein, our results showed that the level of H2O2 in follicular fluid (FF) and reactive oxygen species (ROS) in GCs were increased, while the expression of SOD1, SOD2 and GPX1 was down-regulated in GCs with DOR. In addition, we found that OS within a certain range promoted the expression of CCL5 in GCs, which facilitated the infiltration of CD8+ T cells to the follicles. In vitro co-culture experiment showed that CD8+ T cells inhibited GCs proliferation and promoted their apoptosis through intrinsic apoptosis pathway. Maraviroc, the CCR5 antagonist, alleviated CCL5-induced immune attack of CD8+ T cells. Our results indicated that ROS-CCL5 axis recruited CD8+ T cells into FF resulting in the apoptosis of GCs in DOR. This has further implications for the understanding of the pathology of DOR and searching for the therapeutic management of this disease.


Assuntos
Linfócitos T CD8-Positivos , Ovário , Humanos , Feminino , Espécies Reativas de Oxigênio/metabolismo , Ovário/metabolismo , Linfócitos T CD8-Positivos/metabolismo , Peróxido de Hidrogênio/metabolismo , Atresia Folicular , Células da Granulosa/metabolismo , Apoptose , Quimiocina CCL5/metabolismo
6.
ACS Appl Mater Interfaces ; 15(4): 6187-6201, 2023 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-36655841

RESUMO

Suitable relative humidity is essential for the preservation of cultural relics, food storage, and so on. A special material that can regulate the relative humidity in the microenvironment is particularly important. In this work, several innovative electrospun films with reversible photoresponsive wettability and the ability to regulate microenvironmental relative humidity were prepared. The spiropyran unit of the synthesized copolymer played the most important role in humidity regulation due to its reversible transition between a nonpolar ring-closed state and a polar ring-opened state induced by alternating ultraviolet/visible illumination. More interestingly, the introduction of acrylic acid segments exhibited a controllable hydrogen bond synergistic effect for increasing the range of humidity regulation. The color change and the reversible change ranges of wettability and microenvironmental relative humidity under ultraviolet/visible irradiation are all closely related to the number of acrylic acid segments. Cassie theory, density functional theory (DFT), and interaction region indicator (IRI) analysis were used to characterize this phenomenon. Electrospinning is a promising method to achieve large-scale production that can put such material into practical applications.

7.
Big Data ; 2023 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-36656559

RESUMO

Recognition of handwritten Uchen Tibetan characters input has been considered an efficient way of acquiring mass data in the digital era. However, it still faces considerable challenges due to seriously touching letters and various morphological features of identical characters. Thus, deeper neural networks are required to achieve decent recognition accuracy, making an efficient, lightweight model design important to balance the inevitable trade-off between accuracy and latency. To reduce the learnable parameters of the network as much as possible and maintain acceptable accuracy, we introduce an efficient model named HUTNet based on the internal relationship between floating-point operations per second (FLOPs) and Memory Access Cost. The proposed network achieves a ResNet-18-level accuracy of 96.86%, with only a tenth of the parameters. The subsequent pruning and knowledge distillation strategies were applied to further reduce the inference latency of the model. Experiments on the test set (Handwritten Uchen Tibetan Data set by Wang [HUTDW]) containing 562 classes of 42,068 samples show that the compressed model achieves a 96.83% accuracy while maintaining lower FLOPs and fewer parameters. To verify the effectiveness of HUTNet, we tested it on the Chinese Handwriting Data sets Handwriting Database 1.1 (HWDB1.1), in which HUTNet achieved an accuracy of 97.24%, higher than that of ResNet-18 and ResNet-34. In general, we conduct extensive experiments on resource and accuracy trade-offs and show a stronger performance compared with other famous models on HUTDW and HWDB1.1. It also unlocks the critical bottleneck for handwritten Uchen Tibetan recognition on low-power computing devices.

8.
Eur J Pharmacol ; 940: 175478, 2023 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-36563953

RESUMO

Acetylcholinesterase (AChE) inhibitor (AChEI) is well established as first-line agents for relieving the symptoms of Alzheimer's disease (AD). Injectable sustained-release formulation of AChEI may be suitable for treating AD patients. However, it needs to know whether continuous inhibition of AChE could deteriorate or attenuate myocardial damage if myocardial ischemia (MI) occurs. Huperzine A microspheres (HAM) are a sustained-release formulation releasing sustainably huperzine A (an AChEI) for more than 7 days after a single dose of HAM. This study aimed to investigate the myocardial damage in an isoprenaline (ISO)-induced MI mice model during HAM treatment. The heart injury was evaluated by assaying serum CK-MB, Tn-I and observing histopathological changes. The levels of proinflammatory cytokines in serum were detected. The level of p-P65 and the expression of proteins in the JAK2/STAT3 signaling pathway were assayed with Western blot. Administration with a single dose of HAM resulted in inhibiting the MI-induced increases of CK-MB and Tn-I, alleviating the damage of heart tissue, and decreasing the levels of TNF-α and IL-6. In addition, HAM decreased the levels of p-P65, p-JAK2, and p-STAT3 in heart tissue. The effects of HAM could be weakened or abolished by the specific α7nAChR antagonist. These findings suggest that continuous AChE inhibition could protect the heart from ischemic damage during administration of sustained-release formulation of AChEI, which is associated with the anti-inflammatory effect of HAM by regulating α7nAChR-dependent JAK2/STAT3 signaling pathway.


Assuntos
Traumatismos Cardíacos , Isquemia Miocárdica , Camundongos , Animais , Receptor Nicotínico de Acetilcolina alfa7/metabolismo , Microesferas , Acetilcolinesterase/metabolismo , Preparações de Ação Retardada/farmacologia , Isquemia Miocárdica/tratamento farmacológico , Transdução de Sinais , Fator de Transcrição STAT3/metabolismo , Janus Quinase 2/metabolismo
9.
Neural Regen Res ; 18(5): 1076-1083, 2023 May.
Artigo em Inglês | MEDLINE | ID: mdl-36254996

RESUMO

Studies have shown that gut microbiota metabolites can enter the central nervous system via the blood-spinal cord barrier and cause neuroinflammation, thus constituting secondary injury after spinal cord injury. To investigate the correlation between gut microbiota and metabolites and the possible mechanism underlying the effects of gut microbiota on secondary injury after spinal cord injury, in this study, we established mouse models of T8-T10 traumatic spinal cord injury. We used 16S rRNA gene amplicon sequencing and metabolomics to reveal the changes in gut microbiota and metabolites in fecal samples from the mouse model. Results showed a severe gut microbiota disturbance after spinal cord injury, which included marked increases in pro-inflammatory bacteria, such as Shigella, Bacteroides, Rikenella, Staphylococcus, and Mucispirillum and decreases in anti-inflammatory bacteria, such as Lactobacillus, Allobaculum, and Sutterella. Meanwhile, we identified 27 metabolites that decreased and 320 metabolites that increased in the injured spinal cord. Combined with pathway enrichment analysis, five markedly differential amino acids (L-leucine, L-methionine, L-phenylalanine, L-isoleucine and L-valine) were screened out, which play a pivotal role in activating oxidative stress and inflammatory responses following spinal cord injury. Integrated correlation analysis indicated that the alteration of gut microbiota was related to the differences in amino acids, which suggests that disturbances in gut microbiota might participate in the secondary injury through the accumulation of partial metabolites that activate oxidative stress and inflammatory responses. Findings from this study provide a new theoretical basis for improving the secondary injury after spinal cord injury through fecal microbial transplantation.

10.
Exp Dermatol ; 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36457234

RESUMO

The transition of macrophages from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype is crucial during the wound healing process. In this study, we assess the role of chemokine (C-C motif) ligand 6 (CCL6) in modulating macrophage polarization and wound healing. Initially, we observed significantly upregulated CCL6 expression in the skin tissue on the edge of the wound during the inflammation and proliferation phases. Furthermore, we discovered that the mice treated with rCCL6 had significantly accelerated wound healing and increased levels of M2-type macrophages. Using in vitro models, we found that CCL6 promotes the M2 polarization of macrophages by activating the PI3-kinase/Akt signaling pathway. Additionally, our results showed that CCL6 inhibited macrophage autophagy and accelerated wound healing, whereas the autophagy inducer rapamycin delayed wound healing. Finally, we determined that the PI3-kinase inhibitor LY294002 promoted macrophage autophagy and decreased M2 macrophages, indicating the importance of PI3-K in M2 polarization, and this process was reversed by CCL6. Taken together, our study demonstrates that CCL6 promotes M2 polarization, inhibits macrophage autophagy, and accelerates skin wound healing by activating the PI3-kinase/Akt signaling pathway.

11.
Polymers (Basel) ; 14(24)2022 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-36559931

RESUMO

A composite thin shell with a high fiber volume fraction prepared by resin transfer molding (RTM) may have void defects, which create deformations in the final curing and lead to the final product being unable to meet the actual assembly requirements. Taking a helmet shell as an example, a multi-directional compression RTM (M-CRTM) method with an adjustable injection gap is proposed according to the shape of the thin shell. This method can increase the injection gap to reduce the fiber volume fraction during the injection process, making it easier for the resin to penetrate the reinforcement and for air bubbles to exit the mold. X-ray CT detection shows that the porosity of the helmet shell prepared by the newly developed technology is 36.6% lower than that of the RTM-molded sample. The void's distribution is more uniform, and its size is decreased, as is the number of voids, especially large voids. The results show that the maximum curing deformation of the M-CRTM-molded helmet shell is reduced by 13.7% compared to the RTM molded sample. This paper then further studies the deformation types of the shell and analyzes the causes of such results, which plays an important role in promoting the application of composite thin shells.

12.
J Acoust Soc Am ; 152(6): 3422, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36586850

RESUMO

For rotating sound source localization, there are mainly two types of frequency-domain beamforming methods, the virtual rotating array (VRA) method and mode composition beamforming (MCB). Compared with the VRA method, MCB overcomes the constraint of microphone array configuration and avoids error introduced by interpolation. In order to obtain the MCB result, modal transfer functions, which are the modal coefficients in the analytical solution of the sound field of rotating source, should be pre-calculated. However, the computation of modal transfer functions takes a long time, especially under a large number of considered frequencies. Therefore, the computational efficiency of MCB is limited by the computation of modal transfer functions. In this paper, an expression of modal transfer functions at multiple considered frequencies is derived first. According to this expression, intermediate variables independent of frequency are computed in a fast way, then modal transfer functions at each considered frequency are calculated through these intermediate variables. This expression is successfully applied to improve the computational efficiency of MCB for rotating broadband source localization.

13.
Nat Biomed Eng ; 2022 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-36536254

RESUMO

Hepatobiliary magnetic resonance imaging (MRI) can inform the diagnosis of liver tumours in patients with liver cirrhosis and hepatitis. However, its clinical utility has been hampered by the lack of sensitive and specific contrast agents, partly because hepatocyte-specific nanoparticles, regardless of their surface ligands, are readily sequestered by Kupffer cells. Here we show, in rabbits, pigs and macaques, that the performance of hepatobiliary MRI can be enhanced by an ultrasmall nanoparticle composed of a manganese ferrite core (3 nm in diameter) and poly(ethylene glycol)-ethoxy-benzyl surface ligands binding to hepatocyte-specific transmembrane metal and anion transporters. The nanoparticle facilitated faster, more sensitive and higher-resolution hepatobiliary MRI than the clinically used contrast agent gadoxetate disodium, a substantial enhancement in the detection rate (92% versus 48%) of early-stage liver tumours in rabbits, and a more accurate assessment of biliary obstruction in macaques. The nanoparticle's performance and biocompatibility support the further translational development of liver-specific MRI contrast agents.

14.
J Agric Food Chem ; 70(47): 14831-14840, 2022 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-36383360

RESUMO

Hesperetin-7-O-glucoside (Hes-7-G) is a typical flavonoid monoglucoside, which can be generated from hesperidin with the removal of rhamnose by hydrolysis. Untargeted and targeted metabolomics together with 16S rRNA gene sequencing were employed to explore the exact absorption site of Hes-7-G and its beneficial effect in mice. Intestinal 1H nuclear magnetic resonance (NMR)-based metabolomics screening showed that Hes-7-G is mainly metabolized in the small intestine of mice, especially the ileum segment. Quantification analysis of bile acids (BAs) in the liver, intestinal tract, feces, and serum of mice suggests that Hes-7-G intake accelerates the processes of biosynthesis and excretion of BAs, thus promoting digestion and lowing hepatic cholesterol and triglyceride. 16S rRNA gene sequencing reveals that Hes-7-G significantly elevates the diversity of the gut microbiota in mice, especially those bacteria associated with BA secondary metabolism. These results demonstrated that long-term dietary Hes-7-G plays beneficial roles in health by modulating the gut bacteria and BA metabolism in mice.


Assuntos
Microbioma Gastrointestinal , Hesperidina , Camundongos , Animais , Microbioma Gastrointestinal/genética , Hesperidina/metabolismo , RNA Ribossômico 16S/genética , Ácidos e Sais Biliares/metabolismo , Fígado/metabolismo , Bactérias/genética , Bactérias/metabolismo , Glucosídeos/metabolismo , Camundongos Endogâmicos C57BL
15.
Lipids Health Dis ; 21(1): 118, 2022 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-36369093

RESUMO

BACKGROUND: Total occlusion is the most severe coronary lesion, indicating heavy ischemic burden and poor prognosis. The lipid profile is central to the development of atherosclerotic coronary lesions. Evidence on the optimal lipid measure to be monitored and managed in patients with established coronary artery disease (CAD) is inconclusive. METHODS: Total cholesterol (TC), total triglyceride (TG), low-density lipoprotein cholesterol (LDL-c), nonhigh-density lipoprotein cholesterol (non-HDL-c), lipoprotein (a) [Lp(a)], apolipoprotein B (apoB), non-HDL-c/HDL-c, and apoB/apoA-1 were analyzed in quintiles and as continuous variables. The associations of lipid measures with total occlusion were tested using logistic regression models, visualized with restricted cubic splines, and compared by areas under the receiver operating characteristic curves (AUROC). Discordance analysis was performed when apoB/apoA-1 and non-HDL-c/HDL-c were not in concordance. RESULTS: The prospective cohort study included 10,003 patients (mean age: 58 years; women: 22.96%), with 1879 patients having total occlusion. The risks of total occlusion significantly increased with quintiles of Lp(a), non-HDL-c/HDL-c, and apoB/apoA-1 (all p for trend < 0.001). TG had no association with total occlusion. Restricted cubic splines indicate significant positive linear relations between the two ratios and total occlusion [odds ratio per 1-standard deviation increase (95% confidence interval): non-HDL-c/HDL-c: 1.135 (1.095-1.176), p < 0.001; apoB/apoA-1: 2.590 (2.049-3.274), p < 0.001]. The AUROCs of apoB/apoA-1 and non-HDL-c/HDL-c were significantly greater than those of single lipid measures. Elevation in the apoB/apoA-1 tertile significantly increased the risk of total occlusion at a given non-HDL-c/HDL-c tertile but not vice versa. CONCLUSION: ApoB/apoA-1 confers better predictive power for total occlusion than non-HDL-c/HDL-c and single lipid measures in established CAD patients.


Assuntos
Aterosclerose , Doença da Artéria Coronariana , Humanos , Feminino , Pessoa de Meia-Idade , Apolipoproteína A-I , Estudos Transversais , Estudos Prospectivos , Fatores de Risco , Apolipoproteínas B , Triglicerídeos , Colesterol , Lipoproteína(a) , HDL-Colesterol
16.
Biomimetics (Basel) ; 7(4)2022 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-36412728

RESUMO

With the development of micro/nano-optics, metasurfaces are gaining increasing attention working as novel electromagnetic wave control devices. Among which, metalenses have been developed and applied as a typical application of metasurfaces owing to their unique optical properties. However, most of those previous metalenses can only produce one focal point, which severely limits their applications. Inspired by the fly compound eye, we propose a special kind of spatial multifocal metalens. Our metalenses can reverse the polarization state of the incident circularly polarized light, which is then focused. In addition, a horizontally aligned multifocal metalens can be achieved by designing reasonable phase and region distributions, which is similar to a vertically aligned one. Most significantly, a spatially 3D-arrayed multifocal metalens with low crosstalk is well achieved by combining these two distribution methods. The proposed bionic 3D-arrayed multifocal metalens with amazing focusing effect promises applications in imaging, nanoparticle manipulation, optical communication, and other fields.

17.
J Geriatr Cardiol ; 19(8): 583-593, 2022 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-36339466

RESUMO

OBJECTIVE: To determine whether high-risk patients with three-vessel disease (TVD) with and without prior stroke preferentially benefit from three strategies [percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG) and medical therapy (MT)]. METHODS: A total of 8943 patients with TVD were included in the study. Patients enrolled were stratified into two categories according to the presence or absence of prior stroke history. The primary endpoint was all-cause death. Secondary endpoints included stroke and major adverse cardiac and cerebrovascular event (MACCE), a composite of death, myocardial infarction (MI), unplanned revascularization and stroke. RESULTS: Prior stroke was present in 888 patients (9.9%). These patients were older and had higher rates of comorbidities. During a median follow-up of 7.5 years, patients with prior stroke were strongly associated with increased risks of all-cause death, cardiac death, stroke and MACCE, even after adjusting for confounding variables and results been consistent across either treatment subgroup (PCI, CABG and MT) (all adjusted P < 0.01). Notably, there was a significant interaction between prior stroke history and treatment strategies. Revascularization strategy (PCI or CABG) was associated with a lower incidence of all-cause death and MACCE compared with MT alone, and favorable rates of MACCE, MI and unplanned revascularization in the CABG group compared with the PCI group, but with similar rate of all-cause death regardless of prior stroke history. The prevalence of stroke was significantly higher after CABG when compared with PCI or MT in no prior stroke patients [hazard ratio (HR) = 1.429, 95% CI: 1.132-1.805 for CABG vs. MT; HR = 1.703, 95% CI: 1.371-2.116 for CABG vs. PCI]. CONCLUSIONS: Patients with TVD and prior stroke have poor clinical outcomes. It is essential to balance benefit and risk when determining the optimal treatment strategy for TVD with and without prior stroke.

18.
J Agric Food Chem ; 70(46): 14732-14743, 2022 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-36351282

RESUMO

The sugar moieties of natural flavonoids determine their absorption, bioavailability, and bioactivity in humans. To explore structure-dependent bioactivities of quercetin, isoquercetin, and rutin, which have the same basic skeleton linking different sugar moieties, we systemically investigated the ameliorative effects of dietary these flavonoids on high-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) of mice. Our results revealed that isoquercetin exhibits the strongest capability in improving NAFLD phenotypes of mice, including body and liver weight gain, glucose intolerance, and systemic inflammation in comparison with quercetin and rutin. At the molecular level, dietary isoquercetin markedly ameliorated liver dysfunction and host metabolic disorders in mice with NAFLD. At the microbial level, the three flavonoids compounds, especially isoquercetin, can effectively regulate the gut microbiota composition, such as genera Akkermansia, Bifidobacterium, and Lactobacillus, which were significantly disrupted in NAFLD mice. These comparative findings offer new insights into the structure-dependent activities of natural flavonoids for NAFLD treatment.


Assuntos
Microbioma Gastrointestinal , Hepatopatia Gordurosa não Alcoólica , Humanos , Camundongos , Animais , Hepatopatia Gordurosa não Alcoólica/metabolismo , Quercetina/farmacologia , Glicosídeos/farmacologia , Camundongos Endogâmicos C57BL , Rutina , Flavonoides/farmacologia , Açúcares
19.
Atherosclerosis ; 2022 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-36357218

RESUMO

BACKGROUND AND AIMS: In patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI), the effects of high-sensitivity C-reactive protein (hsCRP) on Lipoprotein(a) (Lp(a))-associated cardiovascular risk remains unclear. This study aimed to investigate the independent and combined association of Lp(a) and hsCRP with cardiovascular events in this specific population. METHODS: A total of 10,424 patients with measurements of both Lp(a) and hsCRP were included in this prospective cohort study. Cox proportional hazards models and Kaplan-Meier analysis were performed to evaluate the relationship between Lp(a), hsCRP and adverse cardiac and cerebrovascular events (MACCE; all-cause death, myocardial infarction, ischemic stroke and revascularization). RESULTS: During 5 years of follow-up, 2140 (20.5%) MACCE occurred. Elevated Lp(a) and hsCRP levels were associated with increased risks of MACCE (p<0.05). Notably, there might be a significant interaction between Lp(a) and hsCRP (P for interaction = 0.019). In the setting of hsCRP≥2 mg/L, significant higher risk of MACCE was observed with Lp(a) 15-29.9 mg/dL (HR: 1.18; 95% CI 1.01-1.39) and Lp(a) ≥30 mg/dL (HR: 1.20; 95% CI 1.04-1.39), whereas such association was attenuated when hsCRP was <2 mg/L with Lp(a) 15-29.9 mg/dL (HR: 0.94; 95% CI 0.80-1.10) and Lp(a) ≥30 mg/dL (HR: 1.12; 95% CI 0.98-1.28). Moreover, when Lp(a) and hsCRP were combined for risk stratification, patients with dual elevation of these two biomarkers had a significant higher risk of MACCE compared with the reference group (Lp(a) < 15 mg/dL and hsCRp<2 mg/L) (p<0.05). CONCLUSIONS: In patients with CAD undergoing PCI, high Lp(a) level was associated with worse outcomes, and this association might be stronger in those with elevated hsCRP concomitantly. Evaluation of Lp(a) and hsCRP together may help identify high-risk individuals for targeted intervention in clinical utility.

20.
Sensors (Basel) ; 22(21)2022 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-36366040

RESUMO

Surgeons are at high risk for developing musculoskeletal symptoms (MSS), like neck and back pain. Quantitative analysis of 3D neck and trunk movements during surgery can help to develop preventive devices such as exoskeletons. Inertial Measurement Units (IMU) and markerless motion capture methods are allowed in the operating room (OR) and are a good alternative for bulky optoelectronic systems. We aim to validate IMU and markerless methods against an optoelectronic system during a simulated surgery task. Intraclass correlation coefficient (ICC (2,1)), root mean square error (RMSE), range of motion (ROM) difference and Bland-Altman plots were used for evaluating both methods. The IMU-based motion analysis showed good-to-excellent (ICC 0.80-0.97) agreement with the gold standard within 2.3 to 3.9 degrees RMSE accuracy during simulated surgery tasks. The markerless method shows 5.5 to 8.7 degrees RMSE accuracy (ICC 0.31-0.70). Therefore, the IMU method is recommended over the markerless motion capture.


Assuntos
Movimento , Pescoço , Fenômenos Biomecânicos , Amplitude de Movimento Articular , Movimento (Física)
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