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1.
J Adv Nurs ; 2020 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-32449228

RESUMO

AIM: The purpose of this study is to design a research protocol for the clinical testing of the "Mommy go" for pregnant women with a risk of postpartum depression. DESIGN: A non-blinded randomized controlled trial. METHODS: A randomized controlled study will be performed from January 2018 to the completion of the study. The intervention group will follow the "Mommy go" protocol and the control group will receive traditional support. We will use the Edinburgh Postpartum Depression Scale and the Chinese version of the Postpartum Depression Predictors Inventory-Revised to measure the risk of postpartum depression in pregnant women. The outcomes are clinical data, postpartum depressive mood, self-efficacy and infant temperament. Outcomes will be assessed using questionnaires and through data generated by digital technologies. DISCUSSION: The expected outcomes are increased self-efficacy and infant temperament, reduced postpartum depressive mood and improvements to postpartum depression. We expect the study to have a clinical impact on future online interventions for postpartum depression in China. IMPACT: This study will provide an internet-based intervention for postpartum depression in China. It will be implemented in clinical practice if it can effectively improve postpartum depression.

2.
J Control Release ; 321: 629-640, 2020 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-32135224

RESUMO

Liver fibrosis leads to over one million deaths annually worldwide. Hepatic stellate cells (HSCs) have been identified as the main executors of liver fibrosis. Unfortunately, no drug has yet been approved for clinical use against liver fibrosis, largely because the tested drugs have been unable to access HSCs and efficiently remove the collagen accumulation involved in fibrogenesis. Here, we designed an efficient HSC-targeting lipid delivery system that carried dual siRNAs intended to both inhibit collagen synthesis and promote collagen degradation, with the goal of realizing enhanced anti-liver fibrosis by bidirectional regulation of collagen accumulation. The delivery system was constructed by using amphiphilic cationic hyperbranched lipoids (C15-PA) for siRNA complexation and helper lipoids (cholesterol-polyethylene glycol-vitamin A, Chol-PEG-VA) for HSCs targeting. The generated vitamin A-decorated and hyperbranched lipoid-based lipid nanoparticles (VLNPs) showed excellent gene-binding ability and transfection efficiency, and enhanced the delivery of siRNAs to HSCs. Fibrotic mice treated with dual siRNA-loaded VLNPs showed a great reduction in the collagen accumulation seen in this model; the enhanced effect of bidirectional regulation reduced the collagen accumulation level in treated mice to almost that seen in normal mice. There was no notable sign of toxicity or tissue inflammation in mice exposed to repeated intravenous administration of the dual siRNA-loaded VLNPs. In conclusion, our results indicate that biocompatible VLNPs designed to exploit precise targeting and an effective bidirectional regulation strategy hold promise for treating liver fibrosis.

3.
Biomaterials ; 230: 119616, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31837823

RESUMO

As hepatic stellate cells (HSCs) are essential for hepatic fibrogenesis, HSCs targeted nano-drug delivery system is a research hotspot in liver fibrosis therapy. However, the excessive deposition of fibrosis collagen (mainly collagen I) in the space of Disse associated with hepatic fibrogenesis would significantly hinder nano-formulation delivery to HSCs. Here, we have prepared a collagenase I and retinol co-decorated polymeric micelle that possess nanodrill-like and HSCs-target function based on poly-(lactic-co-glycolic)-b-poly (ethylene glycol)-maleimide (PLGA-PEG-Mal) (named CRM) for liver fibrosis therapy. Upon encountering collagen I barrier, CRM exerted a nanodrill-like function, efficiently degrading pericellular collagen I and showing greater uptake by human HSCs than other micelle formulations. Besides, CRM could realize excellent accumulation in the fibrotic liver and accurate targeting to activated HSCs in mouse hepatic fibrosis model. Moreover, CRM loaded with nilotinib (CRM/NIL), a second-generation tyrosine kinase inhibitor used in the treatment of liver fibrosis, showed optimal antifibrotic activity. This work suggests that CRM with dual function is an efficient carrier for liver fibrosis drug delivery and collagenase I decorating could be a new strategy for building more efficient HSCs targeted nano-drug delivery system.

4.
Zhongguo Zhong Yao Za Zhi ; 44(20): 4448-4453, 2019 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-31872631

RESUMO

Musk,with unique and intense perfume,was a kind of deep brown precious medicinal material in traditional Chinese medicine. However,the immature musk in musk pot was white and stench. Given the fact that bacterial diversity generated odorous metabolites in animal hosts,in this study,musk samples at three different mature stages,including MJ( the end of June),MA( the end of August) and MO( the end of October) were harvested from three male forest musk deer,and then next-generation sequencing was used to intensively survey the bacterial communities in musk harvested at different mature stages. RESULTS: indicated that the average OTUs per sample at the end of June,August and October were 47 116. 00 ± 1 567. 24( SE),52 009. 00 ± 8 958. 75( SE) and50 004. 67±4 135. 57( SE),respectively. Feature of the musk 16 S rRNA gene showed a total of 418 genera belonging to 52 phyla were observed in all samples. The main microbiota was bacteria,which accounted for 98. 82%,99. 95% and 99. 58% in MJ,MA and MO,respectively. At phylum level,Firmicutes was the most abundant bacterial of MA( 32. 75%) and MO( 39. 19%). While,the major bacterial in MJ was Proteobacteria( 49. 14%). PICRUSt analysis revealed the functions of bacterial in MJ were mainly involved in secretion,while bacterial functions of MA and MO were mainly involved in amino acid or other substance metabolism,which was in accord with the musk secretion physiological process of forest musk deer. This is the first study involved in the bacterial diversity in musk of forest musk deer across the maturation process,while may provide a new insight into the musk generation mechanism.


Assuntos
Cervos/microbiologia , Ácidos Graxos Monoinsaturados , Animais , Florestas , Sequenciamento de Nucleotídeos em Larga Escala , Masculino
5.
Arch Womens Ment Health ; 22(2): 279-287, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-29980903

RESUMO

Postpartum depression is a common complication of childbearing and up to 12 months postpartum. This study aimed to determine the prevalence of postpartum depressive mood (PDM) in China by performing a meta-analysis of published studies. Studies that reported the prevalence of PDM in China were identified by searching the PubMed, Embase, CNKI, and CQVIP databases. Three thousand, one hundred, and two articles were obtained, and after careful evaluation, 26 studies were finally included in the meta-analysis. The combined studies included a total of 7618 cases with 1621 cases of PDM. The studies were assessed on the basis of heterogeneity testing and the potential for publication bias. Stata software 11.0 was used to perform the meta-analysis. The random-effect model showed that the prevalence of PDM was 21% with a 95% confidence interval (CI) of 17-25%. PDM was the highest 0 to 1.5 months after delivery. PDM levels decreased to 10.4% (95% CI 9.7-11.1%, P < 0.001) after publication bias were corrected. Sensitivity analyses evaluated the stability of our results and showed no significant change when any single study was excluded. Subgroup analyses showed that region, instruments used, cut-off score, and time points for depression assessment were positively associated with PDM prevalence. The prevalence of PDM differed among regions, with South Central China and East China exhibiting the lowest prevalence. The prevalence was higher in regions with poor economic development, suggesting that more attention should be devoted to Southwest and North China and that the prevalence of PDM should be evaluated 0 to 1.5 months after delivery.


Assuntos
Depressão Pós-Parto/epidemiologia , Grupo com Ancestrais do Continente Asiático/psicologia , China/epidemiologia , Feminino , Humanos , Prevalência
6.
Zhongguo Zhong Yao Za Zhi ; 39(23): 4522-5, 2014 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-25911794

RESUMO

Forest musk deer (Moschus berezovskii), a rare wild medicinal animal, is listed under the category of the state key protected wildlife list of China. Musk, secreted by the musk glands, is with high economic and medicinal value and used as precious traditional medicine in China. In order to meet the needs of musk in Chinese traditional medicine, forest musk deer farming was conducted in 1950s, but the research progress on musk secretion mechanism was slow. Therefore, by reviewing the histological and anatomical structure of forest musk deer musk gland, the relationship between sex hormones and the musk secretion process, and the molecular mechanism of the musk secretion, the existing problems in investigating the musk secretion mechanism were analyzed and the development trends in this field were also discussed, in order to provide a reference for further studies on the musk secretion mechanism and improve musk production of forest musk deer.


Assuntos
Cervos/metabolismo , Glândulas Exócrinas/química , Ácidos Graxos Monoinsaturados/química , Animais , Glândulas Exócrinas/anatomia & histologia , Glândulas Exócrinas/metabolismo , Ácidos Graxos Monoinsaturados/metabolismo , Masculino
7.
Huan Jing Ke Xue ; 28(6): 1241-4, 2007 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-17674729

RESUMO

Aeration in the inverse direction of effluent was applied as the measure of online backwashing to control membrane pollution in the dynamic membrane bio-reactor treating sewage wastewater. When the intensity of aeration was 5.6 m3/(m2 x h) and the aeration time was 5 min, it took 45 min for the dynamic membrane to recover filtration capacity. With the recovery of dynamic membrane filterability, effluent turbidity was below 5 NTU. The backwashing interval of the reactor could maintain about 15 h. SEM pictures showed that online aeration backwashing in the inverse direction of effluent could efficiently destroy part of dynamic membrane layer. After the dynamic membrane recovery, dynamic membrane could check more than 50% TOC of various molecule weights range > 3 x 10(4). Aeration in the inverse direction of effluent was an economical and effective means of online backwashing in the dynamic membrane bio-reactor.


Assuntos
Reatores Biológicos , Eliminação de Resíduos Líquidos/instrumentação , Desenho de Equipamento , Membranas Artificiais , Eliminação de Resíduos Líquidos/métodos
8.
Guang Pu Xue Yu Guang Pu Fen Xi ; 23(2): 403-6, 2003 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-12961908

RESUMO

In this paper, two simple cyanine dyes were synthesized through allyl alcohol monomer, and were bound to the polished monocrystalline germanium surface using a new chemical method. Raman spectra and X-ray photoelectron spectra (XPS) were used to analyze the dye-binding germanium wafers. In comparison with the contrast germanium wafer, the dye-binding germanium wafers showed that the intensity of the first grade Raman peak of the germanium substrate was reduced and some new Raman peaks corresponding to the dyes appeared from 600 to 3,200 cm-1. And from XPS, C-N, S-C, C-O bonds were proved to have been bound to the germanium surface. In conclusion, the two dyes were bound covalently to germanium wafers through Ge-O bond.


Assuntos
Carbocianinas/química , Corantes Fluorescentes/química , Germânio/química , Fenômenos Químicos , Físico-Química , Cristalização , Condutividade Elétrica , Luz , Propanóis , Semicondutores , Espectrometria por Raios X/métodos , Análise Espectral Raman/métodos
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