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1.
J Clin Pharm Ther ; 2021 Mar 25.
Artigo em Inglês | MEDLINE | ID: mdl-33768534

RESUMO

WHAT IS KNOWN AND OBJECTIVE: Anaplastic Lymphoma Kinase Tyrosine Kinase Inhibitors (ALK TKIs) are standard first-line therapy for non-small cell lung cancer patients with ALK rearrangement. Although some cases of hepatotoxicity related to these drugs have been reported, there is still a lack of investigation on severe hepatotoxicity, such as hepatic failure, with ALK TKIs. METHODS: We evaluated ALK TKI (crizotinib, alectinib, brigatinib, ceritinib and lorlatinib)-induced hepatic failure events (AIHFEs), by using the Reporting Odds Ratio (ROR) and Bayesian Confidence Propagation Neural Network method for mining the adverse event report signals in the FDA Adverse Event Reporting System (FAERS) database from Jan 2013 to Dec 2019. RESULTS AND DISCUSSION: The AIHFEs of "Hepatic failure," "hepatitis fulminant" and "hepatic necrosis" were defined as exposure event signals caused by ALK TKIs. The RORs of "Hepatic failure" were 4.95 (2.36-10.42) in alectinib, 3.77 (1.69-8.40) in ceritinib and 2.45 (1.60-3.76) in crizotinib, respectively. The ROR of "hepatitis fulminant" was 7.86 (3.52-17.54) in crizotinib. The Information Component value of "hepatic necrosis" was 1.97 (0.15) in alectinib. In reports of exposure-event signals, the clinical outcome of eventual death was common and could occur within 3 months. In the reports of "hepatic failure," there was no significant difference in the number of reports between men and women [OR=1.86 (0.94-3.67), p = 0.09]. WHAT IS NEW AND CONCLUSIONS: By mining the adverse event report signals in the FAERS database, we found the exposure event signals of AIHFEs in ALK TKIs were "hepatic failure," "hepatitis fulminant" and "hepatic necrosis". AIHFEs were more likely to appear in the reports of ceritinib, crizotinib and alectinib.

2.
Cell Adh Migr ; 15(1): 74-83, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33734001

RESUMO

Tissue factor (TF) has been extensively studied for tumor metastasis, but its role in mediating cancer cell adhesion to vasculature remains unknown. This study aimed to measure the ability of TF to mediate the adhesion of breast cancer cells to human umbilical vein endothelial cells (HUVECs). MDA-MB-231 cells expressed the highest TF level and adhered more to HUVECs under static and flow conditions, a neutralizing TF antibody abolished the enhanced adhesion of MDA-MB-231 cells to HUVECs. Recombinant human soluble TF (rTF) bonded ß1integrin on HUVECs surfaces, ß1 or α3integrin antibody combined with TF antibody abolished more cell-cell adhesion. These data suggested that TF mediated adhesion of breast cancer cells to endothelial cells may rely on ß1integrin on HUVECs surfaces.

3.
IEEE Trans Cybern ; PP2021 Mar 22.
Artigo em Inglês | MEDLINE | ID: mdl-33750733

RESUMO

Evolutionary multitask learning has achieved great success due to its ability to handle multiple tasks simultaneously. However, it is rarely used in the hyperheuristic domain, which aims at generating a heuristic for a class of problems rather than solving one specific problem. The existing multitask hyperheuristic studies only focus on heuristic selection, which is not applicable to heuristic generation. To fill the gap, we propose a novel multitask generative hyperheuristic approach based on genetic programming (GP) in this article. Specifically, we introduce the idea in evolutionary multitask learning to GP hyperheuristics with a suitable evolutionary framework and individual selection pressure. In addition, an origin-based offspring reservation strategy is developed to maintain the quality of individuals for each task. To verify the effectiveness of the proposed approach, comprehensive empirical studies have been conducted on the homogeneous and heterogeneous multitask dynamic flexible job shop scheduling. The results show that the proposed algorithm can significantly improve the quality of scheduling heuristics for each task in all the examined scenarios. In addition, the evolved scheduling heuristics verify the mutual help among the tasks in a multitask scenario.

4.
IEEE Trans Cybern ; PP2021 Feb 02.
Artigo em Inglês | MEDLINE | ID: mdl-33531323

RESUMO

Dynamic flexible job shop scheduling (JSS) has received widespread attention from academia and industry due to its practical application value. It requires complex routing and sequencing decisions under unpredicted dynamic events. Genetic programming (GP), as a hyperheuristic approach, has been successfully applied to evolve scheduling heuristics for JSS due to its flexible representation. However, the simulation-based evaluation is computationally expensive since there are many calculations based on individuals for making decisions in the simulation. To improve training efficiency, this article proposes a novel multifidelity-based surrogate-assisted GP. Specifically, multifidelity-based surrogate models are first designed by simplifying the problem expected to be solved. In addition, this article proposes an effective collaboration mechanism with knowledge transfer for utilizing the advantages of multifidelity-based surrogate models to solve the desired problems. This article examines the proposed algorithm in six different scenarios. The results show that the proposed algorithm can dramatically reduce the computational cost of GP without sacrificing the performance in all scenarios. With the same training time, the proposed algorithm can achieve significantly better performance than its counterparts in most scenarios while no worse in others.

5.
Cell Death Dis ; 12(2): 153, 2021 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-33542193

RESUMO

Studies have found that RNA-binding proteins (RBPs) are dysfunctional and play a significant regulatory role in the development of glioma. Based on The Cancer Genome Atlas database and the previous studies, we selected heterogeneous nuclear ribonucleoprotein (HNRNPD) as the research candidate and sought its downstream targeted genes. In the present study, HNRNPD, linc00707, and specific protein 2 (SP2) were highly expressed, while zinc fingers and homeboxes 2 (ZHX2) and miR-651-3p were remarkedly downregulated in glioma tissues and cells. HNRNPD, linc00707, and SP2 knockdown or ZHX2 and miR-651-3p overexpression suppressed glioma cells proliferation, migration, and invasion and vasculogenic mimicry (VM) formation. Knockdown of HNRNPD increased the stability of ZHX2 mRNA. ZHX2 bound to the promoter region of linc00707 and negatively regulate its expression. Linc00707 could bind with miR-651-3p, while miR-651-3p bound to the 3' untranslated region (3'UTR) of SP2 mRNA to negatively regulate its expression. The transcription factor SP2 directly bound to the promoter regions of the VM formation-related proteins MMP2, MMP9, and VE-cadherin, playing a role in promoting transcription in order to regulate the VM formation ability of glioma cells.

6.
J Agric Food Chem ; 69(6): 1984-1993, 2021 Feb 17.
Artigo em Inglês | MEDLINE | ID: mdl-33533600

RESUMO

Insecticides are more broadly known to affect insect cellular immunity, but the components in hemocytes and their response to insecticide stress are still unknown. In this paper, a method based on trifluoroacetic acid extraction, followed by IC-CD/ESI-MS analysis, was developed to simultaneously determine tricarboxylic acid (TCA) cycle metabolites and anion components in hemocytes from Mythimna separata larvae. Validation gave excellent selectivity, recovery (88.7-107.6%), linear correlation (r2 > 0.9961), precision (<3.89%), LOD (0.002-0.006 mg/L), LOQ (0.006-0.020 mg/L), and a short chromatographic run. The method was verified by administration of 4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl 3-(1,3-dioxoiso-indolin-2-yl) propanoate (QDP) or emamectin benzoate (EMB) to hemocytes in vitro and larvae in vivo. TCA metabolites including citrate, α-ketoglutarate, fumarate, malate, and oxaloacetate, and anions including acetate, oxalate, chloride, carbonate, and sulfate were identified and clearly separated. QDP and EMB showed a biphasic dose effect on TCA metabolites, and the contrary hormesis paralleled the different actions of QDP and EMB. The inhibition or improvement of cellular immunity depended on the QDP concentration. In conclusion, a highly sensitive, reliable, and robust method was developed, enabling the monitoring of hemocyte immunity by the quantification of TCA metabolites and anion components in minute hemocyte samples.

7.
Environ Monit Assess ; 193(2): 54, 2021 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-33428009

RESUMO

The heavy metal pollution level in soils is heavily affected by the soil particle size distribution. However, the heavy metal loss during particle size extraction and the effect of calcite on the heavy metals removal in terms of the particle size are unclear. In this study, the distribution of heavy metals (Cu, Cd, Cr, Co, Ni, Zn, Pb, U, and V) was determined in five particle fractions (> 2, 2-0.25, 0.25-0.02, 0.02-0.002, and < 0.002 mm) of two soil and one sediment samples collected from the floodplain of Dongchuan, Yunnan Province, Southwest China. The sampled floodplain soils were mainly composed of gravel and sand fractions (> 97%). The concentrations of all nine heavy metals in the sampled soils and sediment increase significantly with decreasing particle sizes. The maximal loss rate of Cd and Cu reaches 54% and 8.6%, respectively, which should be considered in the process of particle size fraction extraction in soils. The removal amount and removal rate of heavy metals in solution by pure calcite ranks in the order of Pb2+ > Cu2+ > Cr6+, while the removal rate of Pb (93.13%) is much higher than that of Cu (24.56%) and Cr (10.71%), which increase with the calcite particle size decreasing. The stabilization of carbonate minerals in soils is crucial for heavy metal pollution control in floodplain soils with high carbonate concentrations in Dongchuan, China.


Assuntos
Metais Pesados , Poluentes do Solo , China , Monitoramento Ambiental , Metais Pesados/análise , Tamanho da Partícula , Solo , Poluentes do Solo/análise
8.
Sci Data ; 8(1): 26, 2021 01 25.
Artigo em Inglês | MEDLINE | ID: mdl-33495477

RESUMO

Water colour is the result of its constituents and their interactions with solar irradiance; this forms the basis for water quality monitoring using optical remote sensing data. The Forel-Ule Index (FUI) is a useful comprehensive indicator to show the water colour variability and water quality change in both inland waters and oceans. In recent decades, lakes around the world have experienced dramatic changes in water quality under pressure from both climate change and anthropogenic activities. However, acquiring consistent water colour products for global lakes has been a challenge. In this paper we present the first time series FUI dataset for large global lakes from 2000-2018 based on MODIS observations. This dataset provides significant information on spatial and temporal changes of water colour for global large lakes during the past 19 years. It will be valuable to studies in search of the drivers of global and regional lake colour change, and the interaction mechanisms between water colour, hydrological factors, climate change, and anthropogenic activities.

10.
Entropy (Basel) ; 22(6)2020 Jun 16.
Artigo em Inglês | MEDLINE | ID: mdl-33286436

RESUMO

Based on advantages of integer and fractional chaotic systems, hybrid chaotic systems and their definitions and some fundamental concepts are proposed, such as hybrid degree (HD), the lowest order (LO) and the total dimension order (TDO). The preliminary properties of hybrid Lorenz systems and hybrid forms of some classic chaotic systems are studied. Then, the relations between HD, LO and TDO with different parameters is investigated in chaotic systems. To be specific, HD is associated with fractional order. It is a directional method to search LO and TDO in chaotic systems. Finally, based on the incommensurate fractional stability theory, we accomplish combination synchronization for three different hybrid order chaotic systems. The simulation results verify the effectiveness of the synchronization controller.

11.
Entropy (Basel) ; 22(11)2020 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-33287028

RESUMO

Although complex Lü systems have been considered in many studies, application of the self-time-delay synchronization (STDS) of complex Lü systems in secure speech communications does not appear to have been covered in much of the literature. Therefore, it is meaningful to study the STDS of complex Lü systems and its application in secure speech communication. First, a complex Lü system with double time-delay is introduced and its chaotic characteristics are analyzed. Second, a synchronization controller is designed to achieve STDS. Third, the improved STDS controller is used to design a speech communication scheme based on a complex Lü system. Finally, the effectiveness of the controller and communication scheme are verified by simulation.

12.
Neurology ; 2020 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-33277416

RESUMO

OBJECTIVE: Accumulating evidence suggests that cancer survivors may have a relatively higher risk of stroke. The hypothesis of this meta-analysis was to determine whether cancer survivors have a relatively higher risk of stroke than non-cancer populations based on the published data from population-based cohort studies. METHODS: Pubmed, Embase and Cochrane Library were searched from inception to February 8, 2020 for population-based cohort studies. Effect estimates with 95% CIs were pooled using the random-effects model. We conducted subgroup analyses and meta-regression to explore sources of heterogeneity and the stability of the results. RESULTS: Twenty population-based cohort studies involving 10,479,530 participants were identified. Overall, the RR for stroke in cancer survivors was 1.66 (95% CI, 1.35-2.04; p < 0.001) compared with that in non-cancer controls, among which survivors of head and neck, hematologic, lung, pancreas and stomach cancer (all p < 0.05) showed consistent significant results, whereas no significant increased risk was observed for other cancer types. The effects were more prominent in cancer survivors with female gender (RR 1.38, 1.18-1.61; p < 0.001), younger age at cancer diagnosis (<45 years) (RR 2.57, 95% CI, 1.27-5.19; p = 0.009) and shorter cancer survival duration (≥1-2 years) (RR 1.69, 95% CI, 1.18-2.42; p = 0.004). Moreover, cancer survivors had a significantly increased risk of ischemic stroke (RR 1.53, 95% CI, 1.28-1.84; p < 0.001) compared with hemorrhagic stroke. CONCLUSIONS: Cancer plays a critical role in the etiologic of stroke. Due to the existence of substantial heterogeneity among the included studies, the results should be interpreted with caution. However, early prevention and effective intervention of stroke in cancer survivors requires attention from the health policy makers.

13.
Int J Cancer ; 2020 Dec 19.
Artigo em Inglês | MEDLINE | ID: mdl-33341092

RESUMO

Branched-chain amino acids (BCAAs), including leucine, isoleucine and valine, may potentially influence cancer progression by various mechanisms including its role in insulin resistance. However, the association of BCAAs with survival among patients with established colorectal cancer (CRC) remains unclear. We evaluated the associations between postdiagnostic BCAA intake with CRC-specific mortality and overall mortality among 1674 patients with nonmetastatic CRC in the Nurses' Health Study and the Health Professionals Follow-up Study. Patients completed a validated food frequency questionnaire. Multivariable hazard ratios (HRs) were calculated using Cox proportional-hazards regression model after adjustment for tumor characteristics and potential confounding factors. Comparing the highest with the lowest quartile intake of postdiagnostic total BCAA, the multivariable HRs were 1.18 (95% confidence interval [CI], 0.75-1.85, P for trend = .46 across quartiles) for CRC-specific mortality and 1.30 (95% CI, 1.01-1.69, P for trend = .04) for all-cause mortality. The multivariable HRs (the highest vs the lowest quartile) for all-cause mortality were 1.33 (95% CI, 1.03-1.73, Ptrend = .02) for valine, 1.28 (95% CI, 0.99-1.66, P for trend = .05) for leucine and 1.25 (95% CI, 0.96-1.61, P for trend = .06) for isoleucine. No statistically significant associations with each of the BCAA intake were observed for CRC-specific mortality (all P for trend > .30). Our findings suggest positive associations between higher intake of dietary BCAAs and risk of all-cause mortality in CRC patients. These findings need to be confirmed and potential mechanisms underlying this association need to be elucidated.

14.
Entropy (Basel) ; 22(12)2020 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-33339118

RESUMO

Although many chaotic systems with time delays have been studied in recent years, most studies have only focused on the theoretical level, without special applications. Therefore, we present a basic introduction of a time delay complex Chen chaotic system, including the influence of parameter changes and time delay factors on the time delay system. On the basis of complex modified projection synchronization (CMPS), we detail the design of a new controller and communication scheme and apply this communication scheme to a wireless body area network (WBAN), in order to encrypt and decrypt body data collected by sensors. Finally, we perform a numerical simulation, demonstrating the effectiveness of the proposed communication scheme.

15.
Chem Commun (Camb) ; 2020 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-33227106

RESUMO

A new rubidium fluorooxoborate, RbB3O4F2, was structurally designed and synthesized by using the strategy of fluorine-introduction into borates. Interestingly, RbB3O4F2 presents the novel [B3O4F2]- chains formed by the unprecedented [B3O5F2]3- fundamental building block. More importantly, RbB3O4F2 has a large birefringence and a deep-UV cutoff edge. The finding of novel [B3O5F2]3- FBB and [B3O4F2]- chains in RbB3O4F2 greatly enriches the structural diversity of fluorooxoborates.

16.
Sensors (Basel) ; 20(22)2020 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-33217939

RESUMO

With the development of citizen science, digital cameras and smartphones are increasingly utilized in water quality monitoring. The smartphone application HydroColor quantitatively retrieves water quality parameters from digital images. HydroColor assumes a linear relationship between the digital pixel number (DN) and incident radiance and applies a grey reference card to derive water leaving reflectance. However, image DNs change with incident light brightness non-linearly, according to a power function. We developed an improved method for observing and calculating water leaving reflectance from digital images based on multiple reflectance reference cards. The method was applied to acquire water, sky, and reflectance reference card images using a Cannon 50D digital camera at 31 sampling stations; the results were validated using synchronously measured water leaving reflectance using a field spectrometer. The R2 for the red, green, and blue color bands were 0.94, 0.95, 0.94, and the mean relative errors were 27.6%, 29.8%, 31.8%, respectively. The validation results confirm that this method can derive accurate water leaving reflectance, especially when compared with the results derived by HydroColor, which systematically overestimates water leaving reflectance. Our results provide a more accurate theoretical foundation for quantitative water quality monitoring using digital and smartphone cameras.

17.
Artigo em Inglês | MEDLINE | ID: mdl-33170322

RESUMO

The objective of present work is to evaluate possible interactions among four clinically-used vascular epidermal growth factor receptor (VEGFR)-tyrosine kinase inhibitors (TKIs), including apatinib, cabozantinib, sorafenib, and sunitinib, with epidermal growth factor receptor (EGFR)-TKI gefitinib. This may advance knowledge regarding possible dual-target suppression strategies for advanced NSCLC, including VEGFR-TKI plus EGFR-TKI. The in vitro metabolism study demonstrated that apatinib inhibited the formation of metabolite M537194 with moderate effect, and inhibited another metabolite formation of M523595 with strong effect, in both human and rat liver microsomes. Sorafenib, cabozantinib, and sunitinib had no significant inhibitory effect on gefitinib metabolism. The results of the in vivo pharmacokinetics study were consistent with the in vitro metabolism study: the AUC0-t, AUC0-∞ and Cmax of gefitinib increased significantly when co-administered with apatinib by 26.8, 28.7, and 19.8%, respectively. Cabozantinib, sorafenib, and sunitinib exhibited no effect on gefitinib pharmacokinetics. Molecular docking was applied to investigate the binding mode between TKIs and CYP2D6. The docking results illustrated that binding characteristics of apatinib and gefitinib with CYP2D6 were similar, which accounts for competitive mechanism of apatinib-inhibited gefitinib metabolism. In summary, apatinib inhibited the metabolism of gefitinib in vitro and in vivo that were mediated by CYP2D6 and CYP3A4. In addition, cabozantinib, sorafenib, and sunitinib expressed no interaction with gefitinib. The results of the present study may provide a basis and valuable information for the development of treatment strategies.

18.
Amino Acids ; 2020 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-33236256

RESUMO

Protonectin was a typical amphiphilic antimicrobial peptide with potent antimicrobial activity against Gram-positive and Gram-negative bacteria. In the present study, when its eleventh amino acid in the sequence was substituted by phenylalanine, the analog named phe-Prt showed potent antimicrobial activity against Gram-positive bacteria, but no antimicrobial activity against Gram-negative bacteria, indicating a significant selectivity between Gram-positive bacteria and Gram-negative bacteria. However, when Gram-negative bacteria were incubated with EDTA, the bacteria were susceptible to phe-Prt. Next, the binding effect of phe-Prt with LPS was determined. Our result showed that LPS could hamper the bactericidal activity of phe-Prt against Gram-positive bacteria. The result of zeta potential assay further confirmed the binding effect of phe-Prt with LPS for it could neutralize the surface charge of E. coli and LPS. Then, the effect of phe-Prt on the integrity of outer membrane of Gram-negative bacteria was determined. Our results showed that phe-Prt had a much weaker disturbance to the outer membrane of Gram-negative bacteria than the parent peptide protonectin. In summary, the introduction of L-phenylalanine into the sequence of antimicrobial peptide protonectin made phe-Prt show significant selectivity against Gram-positive bacteria, which could partly be attributed to the delay effect of LPS for phe-Prt to access to cell membrane. Although further study is still needed to clarify the exact mechanism of selectivity, the present study provided a strategy to develop antimicrobial peptides with selectivity toward Gram-positive and Gram-negative bacteria.

19.
IEEE Trans Cybern ; PP2020 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-33079689

RESUMO

Dynamic flexible job-shop scheduling (DFJSS) is a challenging combinational optimization problem that takes the dynamic environment into account. Genetic programming hyperheuristics (GPHH) have been widely used to evolve scheduling heuristics for job-shop scheduling. A proper selection of the terminal set is a critical factor for the success of GPHH. However, there is a wide range of features that can capture different characteristics of the job-shop state. Moreover, the importance of a feature is unclear from one scenario to another. The irrelevant and redundant features may lead to performance limitations. Feature selection is an important task to select relevant and complementary features. However, little work has considered feature selection in GPHH for DFJSS. In this article, a novel two-stage GPHH framework with feature selection is designed to evolve scheduling heuristics only with the selected features for DFJSS automatically. Meanwhile, individual adaptation strategies are proposed to utilize the information of both the selected features and the investigated individuals during the feature selection process. The results show that the proposed algorithm can successfully achieve more interpretable scheduling heuristics with fewer unique features and smaller sizes. In addition, the proposed algorithm can reach comparable scheduling heuristic quality with much shorter training time.

20.
Plant Cell ; 32(12): 3792-3811, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33093148

RESUMO

Following germination in the dark, Arabidopsis (Arabidopsis thaliana) seedlings undergo etiolation and develop apical hooks, closed cotyledons, and rapidly elongating hypocotyls. Upon light perception, the seedlings de-etiolate, which includes the opening of apical hooks and cotyledons. Here, we identify Arabidopsis Small Auxin Up RNA17 (SAUR17) as a downstream effector of etiolation, which serves to bring about apical hook formation and closed cotyledons. SAUR17 is highly expressed in apical hooks and cotyledons and is repressed by light. The apical organs also express a group of light-inducing SAURs, as represented by SAUR50, which promote hook and cotyledon opening. The development of etiolated or de-etiolated apical structures requires asymmetric differential cell growth. We present evidence that the opposing actions of SAUR17 and SAUR50 on apical development largely result from their antagonistic regulation of Protein Phosphatase 2C D-clade 1 (PP2C-D1), a phosphatase that suppresses cell expansion and promotes apical hook development in the dark. SAUR50 inhibits PP2C-D1, whereas SAUR17 has a higher affinity for PP2C-D1 without inhibiting its activity. PP2C-D1 predominantly associates with SAUR17 in etiolated seedlings, which shields it from inhibitory SAURs such as SAUR50. Light signals turn off SAUR17 and upregulate a subgroup of SAURs including SAUR50 at the inner side of the hook and cotyledon cells, leading to cell expansion and unfolding of the hook and cotyledons.

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