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1.
Sci Total Environ ; 723: 137775, 2020 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-32213399

RESUMO

Biochar is a product of biomass thermochemical conversion. Its yield and quality vary significantly with the production technology and process parameters, which also affect its performance in agro and forestry systems. In this review, biochar production technologies including slow pyrolysis, fast pyrolysis, gasification, and torrefaction were compared. The yield of biochar was found to decrease with faster heating rate or more oxygen available. The benefits of biochar application to agro and forestry systems were discussed. Improvements in soil health, plant growth, carbon sequestration, and greenhouse gas mitigation are apparent in many cases, but opposite results do exist, indicating that the beneficial aspect of biochar are limited to particular conditions such as the type of biochar used, the rate of application, soil type, climate, and crop species. Limitations of current studies and future research needed on biochar are also discussed. Specifically, the relationships among biochar production technologies, biochar properties, and biochar performance in agro and forestry systems must be better understood.

2.
Oxid Med Cell Longev ; 2020: 7286958, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32215177

RESUMO

Hyperlipidemia is considered one of the most important risk factors for erectile dysfunction (ED). To determine the effect of sodium tanshinone IIA sulfonate (STS) as an antioxidant agent on ED in high-fat diet- (HFD-) induced hyperlipidemia in rats and to investigate if STS administration could improve erectile function via hydrogen sulfide (H2S) production by inhibition of oxidative stress. Hyperlipidemia was induced in Sprague-Dawley rats by feeding HFD for 16 weeks. The rats were randomly divided into 3 groups: control, HFD, and HFD treated with STS (10 mg/kg/day for 12 weeks, intraperitoneal injection). Erectile function including intracavernosal pressure (ICP), H2S production, and antioxidant capacity was assessed. In addition, cavernosal smooth muscle cells (CSMC) isolated from SD rats were pretreated with STS in vitro and exposed to H2O2. Expressions of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1), activity of antioxidant enzymes, and H2S-generating enzymes within CSMC were examined. ICP was significantly decreased in HFD rats compared with control. In addition, decreased H2S production and expression of cystathionine É£-lyase (CSE) and cystathionine ß-synthase (CBS) associated with increased oxidative stress were observed in the penile tissue of HFD rats. However, all these changes were reversed by 16 weeks after STS administration. STS also increased antioxidant defense as evidenced by increased expression of Nrf2/HO-1 in the penile tissue of HFD rats. In CSMC, pretreatment with STS attenuated the decreased expression of CSE and CBS and H2S production by H2O2. STS exerted similar protective antioxidative effect as shown in the in vivo hyperlipidemia model. The present study demonstrated the redox effect of STS treatment on ED via increased H2S production in HFD-induced hyperlipidemia rat model by increased antioxidant capacity via activation of the Nrf2/HO-1 pathway, which provides STS potential clinical application in the treatment of hyperlipidemia-related ED.

4.
Oncologist ; 25(3): 203-207, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32162810

RESUMO

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Growing evidence supports gene fusions as good candidates for molecularly targeted therapy in CRC. Here we describe a case of a 63-year-old man who had a radical right hemicolectomy procedure 24 months ago. Pathological diagnosis indicated colorectal adenocarcinoma with stage pT4N2bMx. During re-examination in December 2016, positron emission tomography/computed tomography scans indicated relapse with multiple lymph nodes metastasis. Then the patient received a nine-cycle combination treatment of XELOX and bevacizumab and showed progressive disease (PD). Subsequently, the patient was treated with bevacizumab plus FOLFIRI for 2 months before discontinuation because of adverse events. Paraffin sections of postoperative colorectal tissue were subjected to next-generation sequencing, and epidermal growth factor receptor (EGFR) amplification and rare EGFR-SEPT14 fusion were identified. The patient then received erlotinib, an EGFR tyrosine kinase inhibitor (TKI), and achieved a partial response. However, the patient subsequently showed PD, and a new variant, EGFRvIII, appeared in metastasis, which may be involved in erlotinib resistance. We suggest that there is value in treating patients harboring EGFR fusions with EGFR TKI therapy, and EGFR-SEPT14 fusion may be used as a therapeutic target for CRC. KEY POINTS: To the authors' knowledge, this is the first report of EGFR-SEPT14 fusion in colorectal cancer. The patient achieved a partial response after treatment with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib. This report expands the list of gene fusions in colorectal cancer and highlights new targets for the therapeutic intervention. EGFRvIII may be involved in erlotinib resistance, which is rare in colorectal cancer.

5.
J Nat Prod ; 2020 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-32191465

RESUMO

Overexpression of phosphopantetheinyl transferase (PPtase)-encoding genes sfp and svp in the marine-derived Verrucosispora sp. SCSIO 40062 led to the production of two new aminofuran monomers, proximicin F (1) and proximicin G (3) and a new dimer diproximicin A (2), along with two known compounds, proximicins B (4) and C (5). Their structures were unambiguously elucidated on the basis of detailed NMR spectroscopic analysis and high-resolution electrospray ionization mass spectrometry (HRESIMS) data. Proximicin B (4) showed moderate antibacterial activities against Staphylococcus aureus, methicillin-resistant S. aureus, and Bacillus subtilis.

6.
Waste Manag ; 105: 492-500, 2020 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-32143145

RESUMO

Sequential potassium hydroxide (KOH)-phosphoric acid (H3PO4) activation was applied to biomass waste to fabricate activated carbon microspheres (mCMs) with a controllable porous structure. Carbon microspheres (CMs) were first synthesized from xylose using a bottom-up approach of hydrothermal carbonization. Sequential KOH and H3PO4 activation was applied to the CMs in a KOH-carbon solid reaction. This created pores, which were further enlarged by adsorption of H3PO4. The KOH:carbon (C) and H3PO4:C molar ratios, and the H3PO4 heating rate and activation time, were varied to investigate the effect on average pore size and pore distribution. A uniform porous structure was formed without destruction of the spherical shape, and an almost 700-fold increase in surface area was obtained over the non-activated CMs. Following activation with H3PO4, phosphorous groups were found to be present at the surface of the carbon microspheres. The mCM was tested as a supercapacitor electrode and was shown to have a maximum specific capacitance of up to 277F g-1. A Ragone plot showed the maximum power density to be 173.88 W Kg-1. This increased specific capacitance was attributed to the increase in surface area and the presence of phosphorous-containing acid sites on the material surface.


Assuntos
Xilose , Biomassa , Capacitância Elétrica , Microesferas , Porosidade
7.
J Am Heart Assoc ; 9(6): e014421, 2020 Mar 17.
Artigo em Inglês | MEDLINE | ID: mdl-32131687

RESUMO

Background Sex differences in health status outcomes after percutaneous coronary intervention among patients without acute myocardial infarction are not well described. Methods and Results A total of 2237 patients (33.4% women) without acute myocardial infarction undergoing percutaneous coronary intervention were enrolled from 39 Chinese tertiary hospitals in the PEACE (China Patient-centered Evaluative Assessment of Cardiac Events) prospective percutaneous coronary intervention study. Data were collected immediately before and 1 year following percutaneous coronary intervention. Health status was measured using the disease-specific Seattle Angina Questionnaire (SAQ) Angina Frequency and Quality of Life domains, as well as the SAQ Summary Score. Among the study population, women were older, more often single, had lower levels of education, and had a higher prevalence of cardiac risk factors such as hypertension and diabetes mellitus. Women had lower mean 1-year SAQ Angina Frequency scores (mean±SD, 91.0±17.3 versus 93.9±13.3; P<0.01), SAQ Quality of Life scores (mean±SD, 67.3±23.0 versus 70.6±21.6; P<0.01), and SAQ Summary Scores (mean±SD, 81.6±13.8 versus 84.8±11.9; P<0.01), a difference of marginal clinical significance that persisted after multivariable adjustment. A slightly larger improvement in the SAQ Summary Score was observed in women as compared with men (20.9±22.6 versus 18.5±21.3; P=0.007) in unadjusted analysis. However, women were less likely to achieve clinically significant improvement in SAQ Angina Frequency (adjusted odds ratio, 0.67; 95% CI, 0.45-1.00) and SAQ Quality of Life (adjusted odds ratio, 0.73; 95% CI, 0.56-0.96) after adjustment. Conclusions There were no clinically significant differences in 1-year health status outcomes and improvement in health status by sex among patients without acute myocardial infarction following percutaneous coronary intervention. However, female sex was associated with poorer 1-year health status and a lower likelihood of experiencing clinically improvement in health status. Clinical Trial Registration URL: https://www.clinicaltrials.gov/. Unique identifier: NCT01624922.

8.
Enzyme Microb Technol ; 135: 109498, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32146931

RESUMO

Whole-cell biocatalysts could be used in wide-ranging applications. In this study, a new kind of whole-cell biocatalyst was successfully constructed by genetically immobilizing soybean seed coat peroxidase (SBP) on the cell surface of Yarrowia lipolytica Po1h, using a new integrative surface display expression vector (pMIZY05). The coding sequence of SBP was optimized and chemically synthesized, then inserted into pMIZY05 to generate expression plasmid pMIZY05-oEp. A DNA fragment corresponding to SBP and selection marker expression cassettes, without bacterial sequences, was released from pMIZY05-oEp by enzyme digestion and used to transform host yeast cells. A transformant (CM11) with a high recombinant SBP activity of 1571.9 U/mL was obtained, and recombinant SBP was proved to be successfully anchored on cell surface by testing the activities of different cellular fractions. After optimization of culture conditions, the recombinant SBP activity of CM11 was increased to 4187.8 U/mL. Afterwards, biochemical properties of the recombinant SBP were determined: optimum catalytic conditions were 37.5℃ at pH 3.5, and recombinant SBP exhibited high stability during thermal or acidic treatment. Recombinant activity of cell-displayed SBP was re-examined at optimum temperature and pH, which promoted an increase up to 4432.5 U/mL. To our knowledge, this represents the highest activity ever reported for heterologous expression of SBP. This study also provides a useful strategy for heterologous expression of proteins which could be toxic to intracellular content of host cells.

9.
Exp Cell Res ; : 111949, 2020 Mar 05.
Artigo em Inglês | MEDLINE | ID: mdl-32145254

RESUMO

Farnesoid X receptor (FXR) is a metabolic nuclear receptor, which protects liver from many endogenous and exogenous injuries. Metallothioneins (MTs) belong to a low-molecular-weight protein family involved in metal homeostasis and the regulation of hepatic oxidative stress. In the present study, we aimed to investigate the effect of FXR on hepatic MT1 expression and the underlying mechanism. C57BL/6 mice or primary cultured mouse hepatocytes were treated with the synthetic FXR ligand GW4064 or natural ligand CDCA. RNA-Sequencing (RNA-seq) analysis was performed to identify gene expression profile in the livers of mice treated with GW4064. Real-time PCR and Western blot were applied to determine the expression of MT1 and other FXR target genes in the livers of mice and primary hepatocytes treated with GW4064 and CDCA. Cellular and subcellular locations of MT1 in the livers of mice treated with GW4064 were examined using immunohistochemistry assay. FXR small interfering RNAs (siRNA) was transfected to silence FXR. Luciferase reporter and chromatin immunoprecipitation (ChIP) assays were utilized to confirm the regulation of MT1 gene promoter activity by FXR. RNA-seq analysis revealed that GW4064 treatment significantly induced MT1 expression in mouse liver. Consistently, MT1 expression in the hepatocytes of mouse livers and cultured hepatocytes was upregulated by GW4064 as well as CDCA. In addition, adenovirus-mediated overexpression of FXR markedly increased, while siRNA-mediated FXR silencing significantly suppressed MT1 expression in cultured hepatocytes. Luciferase reporter and ChIP assays further confirmed that the MT1 gene was under the direct control of FXR. Collectively, our findings demonstrate that MT1 is a novel target gene of FXR and may contribute to antioxidative capacity of FXR in liver diseases.

10.
Artigo em Inglês | MEDLINE | ID: mdl-32169372

RESUMO

OBJECTIVE: Whether mitral valve repair is superior to replacement in the population with rheumatic heart disease has been debated. This study aims to compare outcomes of repair with replacement by the propensity score method. METHODS: This observational, prospective study enrolled patients with rheumatic heart disease who underwent mitral valve repair and replacement from January 2011 to April 2019. The propensity score method was used to select 2 groups with similar baseline characteristics. Baseline, clinical, and follow-up data were collected. Clinical outcomes included death from any cause, reoperation, and valve-related complications. RESULTS: The overall population before matching (N = 1644) included 612 patients who underwent repair and 1032 patients who underwent replacement. The propensity score analysis generated matches for 1058 patients (529 pairs). The median follow-up time was 4.12 years. Early mortality and death from any cause during follow-up were significantly lower in the repair group compared with the replacement group (hazard ratio, 0.19; 95% confidence interval [CI], 0.05-0.64; P = .003; hazard ratio, 0.38; 95% CI, 0.19-0.74; P = .003, respectively). Patients in the repair group had a lower risk of valve-related complications compared with patients in the replacement group (subhazard ratio, 0.44; 95% CI, 0.21-0.90; P = .025). In terms of reoperation, no significant difference was observed between the repair and replacement groups (subhazard ratio, 2.54; 95% CI, 0.89-7.22; P = .081). CONCLUSIONS: The results suggest that rheumatic mitral valve repair in select patients is superior to mitral valve replacement with regard to lower mortality and fewer valve-related complications; meanwhile, it has a comparable risk of reoperation compared with replacement.

11.
Artigo em Inglês | MEDLINE | ID: mdl-32062366

RESUMO

Albendazole (ABZ) is the first-line drug in treating echinococcosis, which is recommended by WHO. To address the poor bioavailability of albendazole, liposomal albendazole was formulated and is available in our hospital for many years. In this study, a sensitive, reliable and accurate UPLC-Q-TOF-MS method was developed and validated for the determination of albendazole and its metabolites, albendazole sulfoxide (ABZSO), albendazole sulfone (ABZSO2) and albendazole-2-aminosulfone (ABZSO2NH2) in naturally echinococcus granulosus (E. granulosus) infected sheep plasma and tissues with mebendazole (MBZ) as the internal standard (IS). Plasma and tissues samples were prepared by protein precipitation method. The separation was performed on an ACQUITY UPLC® BEH C18 column (2.1 × 50 mm, 1.7 µm) with a gradient mobile phase consisting of methanol and water containing 0.1% formic acid at 0.4 mL/min. The detection was performed on a quadrupole time-of-flight (Q-TOF) high-resolution mass spectrometer using positive electrospray ionization (ESI) source with a chromatographic run time of 6.0 min. The detection was operated using target ions of [M + H]+ at m/z 266.096 for ABZ, m/z 282.091 for ABZSO, m/z 298.086 for ABZSO2, m/z 240.081 for ABZSO2NH2 and m/z 296.104 for IS in selective ion mode, respectively. This method was validated in terms of selectivity, linearity, precision, accuracy, recovery, matrix effect, dilution effect, carryover effects, stability, calibration curve and LLOQ. All validation parameter results were within the acceptable range described in guideline for bioanalytical method validation. This method has been successfully applied to the pharmacokinetic study following single and multiple oral dose of 10 mg/kg liposomal albendazole, and tissue distribution study following multiple oral dose of 10 mg/kg, with emulsion albendazole as the reference preparation. The results in the article will provide valuable information for use in clinical applications of liposomal albendazole and also be beneficial for further development of liposomal albendazole in future studies.


Assuntos
Albendazol/sangue , Albendazol/farmacocinética , Cromatografia Líquida de Alta Pressão/métodos , Equinococose/tratamento farmacológico , Doenças dos Ovinos/tratamento farmacológico , Albendazol/química , Albendazol/uso terapêutico , Animais , Equinococose/veterinária , Echinococcus granulosus , Modelos Lineares , Lipossomos , Espectrometria de Massas/métodos , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Ovinos , Distribuição Tecidual
12.
Pharmacol Rep ; 2020 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-32048266

RESUMO

BACKGROUND: Prostate cancer (PCa) is the most common malignancy in men and in the absence of any effective treatments available. METHODS: For the development of potential anticancer agents, 24 kinds of naftopidil-based arylpiperazine derivatives containing the bromophenol moiety were synthesized and characterized by using spectroscopic methods. Their pharmacological activities were evaluated against human PCa cell lines (PC-3 and LNCaP) and a1-adrenergic receptors (a1-ARs; α1a, α1b, and α1d-ARs). The structure-activity relationship of these designed arylpiperazine derivatives was rationally explored and discussed. RESULTS: Among these derivatives, 3c, 3d, 3h, 3k, 3o, and 3s exhibited the most potent activity against the tested cancer cells, and some derivatives with potent anticancer activities exhibited better a1-AR subtype selectivity than others did (selectivity ratio > 10). CONCLUSION: This work provided a potential lead compound for the further development of anticancer agents for PCa therapy.

13.
Genomics ; 112(3): 2510-2515, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32045670

RESUMO

To investigate the association between SNPs in human IGF2/H19 gene locus and epithelial ovarian cancer (EOC) risk, we performed a case-control study in 422 individuals (219 EOC patients and 203 cancer-free controls). Four SNPs (rs2525885, rs2839698, rs3741206, rs3741219) were found to be related with EOC risk. Specifically, the minor allele C of rs2525885 and allele A of rs2839698 was associated with elevated EOC genetic susceptibility under both dominant and recessive models (TC + CC vs TT: adjusted OR: 1.61, P = .031; CC vs TT + TC: adjusted OR: 4.87, P = .014; GA + AA vs GG: adjusted OR: 1.63, P = .023; AA vs GG + GA: adjusted OR: 2.43, P = .007). For rs3741206, the genotype TC + CC was associated with a significant decrease in EOC risk with the TT genotype as reference in a dominant genetic model (adjusted OR: 0.44, P = .003), while for rs3741219, genotype AA was associated with a 59% decrease in EOC risk only in the recessive model (adjusted OR: 0.41, P = .038). In the stratified analysis, an increased risk associated with the variant genotypes was observed in only subjects aged >47 years for rs2525885 (adjusted OR = 2.04, P = .024), rs2839698 (adjusted OR = 2.50, P = .047) and rs3741206 (adjusted OR = 0.37, P = .009), respectively. What's more, the TC + CC genotype of rs2525885 was significantly associated with advanced FIGO stage (III vs II, adjusted OR = 2.73, P = .040).

14.
Artigo em Inglês | MEDLINE | ID: mdl-32092917

RESUMO

Soil erosion risk assessment is an essential foundation for the planning and implementation of soil and water conservation projects. The commonality among existing studies is that they considered different indicators (e.g., rainfall and slope) in order to determine the soil erosion risk; however, the majority of studies in China neglect one important indicator, namely the slope aspect. It is widely accepted that the vegetation and distribution of rainfall differs according to the different slope aspects (such as sunny slope and shady slope) and these attributes will accordingly influence the soil erosion. Thus, existing studies neglecting this indicator cannot reflect the soil erosion well. To address this problem, a flexible soil erosion risk assessment method that supports decision makers in identifying priority areas in soil and water conservation planning was developed in the present study. Firstly, in order to verify the impact of the slope aspect on soil erosion, field investigations were conducted, and its impact on the characteristics of the community in the study area was analyzed. Secondly, six assessment indicators were selected, including slope gradient, precipitation, NDVI, land use, soil texture and slope aspect. Next, a developed multi-criteria decision analysis (MCDA) method based on the Choquet integral was adopted to assess the soil erosion risk. The MCDA method, combining objective data with subjective assessment based on Choquet integral, could solve the weight problem encountered when using the quantitative method. The parameters required can be modified according to the soil erosion types, assessment scales, and data availability. The synergistic and inhibitory effects among the soil erosion parameters were also considered in the assessment. Finally, the soil erosion risk results in the Xinshui River watershed revealed that more attention should be paid to the slope of farmland and grassland during the planning and management of soil and water conservation projects. The methodology used in the current study can support decision makers in planning and implementing soil and water conservation measures in regions with different erosion types.

15.
Database (Oxford) ; 20202020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-32103267

RESUMO

Drosophila melanogaster is a well-established model organism that is widely used in genetic studies. This species enjoys the availability of a wide range of research tools, well-annotated reference databases and highly similar gene circuitry to other insects. To facilitate molecular mechanism studies in Drosophila, we present the Predicted Drosophila Interactome Resource (PDIR), a database of high-quality predicted functional gene interactions. These interactions were inferred from evidence in 10 public databases providing information for functional gene interactions from diverse perspectives. The current version of PDIR includes 102 835 putative functional associations with balanced sensitivity and specificity, which are expected to cover 22.56% of all Drosophila protein interactions. This set of functional interactions is a good reference for hypothesis formulation in molecular mechanism studies. At the same time, these interactions also serve as a high-quality reference interactome for gene set linkage analysis (GSLA), which is a web tool for the interpretation of the potential functional impacts of a set of changed genes observed in transcriptomics analyses. In a case study, we show that the PDIR/GSLA system was able to produce a more comprehensive and concise interpretation of the collective functional impact of multiple simultaneously changed genes compared with the widely used gene set annotation tools, including PANTHER and David. PDIR and its associated GSLA service can be accessed at http://drosophila.biomedtzc.cn.

16.
Chemosphere ; 243: 125331, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31995863

RESUMO

The effects of reaction temperature, residence time, sulfuric acid and potassium hydroxide on the total concentration and speciation of N and P, potentially toxic elements (salts and metal elements) of pig manure during its hydrothermal carbonization (HTC) were investigated. Concentrations of Cl, K, Na and Mg in the hydrochars were much lower but total N, P and nitrate-nitrogen (NO3--N) contents were significantly higher than in untreated pig manure. The acid-extractable fractions of Cu and Zn in hydrochars were 0.03-0.63 and 0.17-0.66 times lower than those in pig manure and decreased significantly with increasing reaction temperature. The addition of sulfuric acid (H2SO4) or potassium hydroxide (KOH) in HTC reduced the contents of P, Ca, Mg, Cl and heavy metal elements (HMEs) in hydrochars, and the removal rates of Cu and Zn were up to 55% and 59%, respectively. Overall, the rapid treatment of pig manure by HTC reduced the harm of salts and HMEs, and effectively recovered the nutrients in pig manure. The HTC under alkaline conditions was desirable for optimizing the main elemental composition of the hydrochars.


Assuntos
Esterco , Eliminação de Resíduos Líquidos/métodos , Animais , Carbono , Hidróxidos/química , Esterco/análise , Metais Pesados/análise , Minerais/análise , Nitrogênio/análise , Fósforo/química , Compostos de Potássio/química , Ácidos Sulfúricos/química , Suínos , Temperatura Ambiente , Fatores de Tempo
17.
BMC Infect Dis ; 20(1): 64, 2020 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-31964345

RESUMO

BACKGROUND: The aim of our study was to analyze the risk factors of nosocomial infection after cardiac surgery in children with congenital heart disease (CHD). METHODS: We performed a retrospective cohort study, and children with CHD who underwent open-heart surgeries at Shanghai Children's Medical Center from January 1, 2012 to December 31, 2018 were included. The baseline characteristics of these patients of different ages, including neonates (0-1 months old), infants (1-12 months old) and children (1-10 years old), were analyzed, and the association of risk factors with postoperative nosocomial infection were assessed. RESULTS: A total of 11,651 subjects were included in the study. The overall nosocomial infection rate was 10.8%. Nosocomial infection rates in neonates, infants, and children with congenital heart disease were 32.9, 15.4, and 5.2%, respectively. Multivariate logistic regression analysis found age (OR 0798, 95%CI: 0.769-0.829; P < 0.001), STS risk grade (OR 1.267, 95%CI: 1.159-1.385; P < 0.001), body mass index (BMI) <5th percentile (OR 1.295, 95%CI: 1.023-1.639; P = 0.032), BMI >95th percentile (OR 0.792, 95%CI: 0.647-0.969; P = 0.023), cardiopulmonary bypass (CPB) time (OR 1.008, 95%CI: 1.003-1.012; P < 0.001) and aortic clamping time (OR 1.009, 1.002-1.015; P = 0.008) were significantly associated with nosocomial infection in CHD infants. After adjusted for confounding factors, we found STS risk grade (OR 1.38, 95%CI: 1.167-1.633; P < 0.001), BMI < 5th percentile (OR 1.934, 95%CI: 1.377-2.715; P < 0.001), CPB time (OR 1.018, 95%CI: 1.015-1.022; P < 0.001), lymphocyte/WBC ratiocut off value (OR 1.546, 95%CI: 1.119-2.136; P = 0.008) were significantly associated with nosocomial infection in CHD children. CONCLUSION: Our study suggested STS risk grade, BMI, CPB duration, low lymphocyte/WBC or high neutrophil/WBC ratio were independently associated with nosocomial infection in CHD infant and children after cardiac surgery.

18.
Sci Total Environ ; 714: 136628, 2020 Apr 20.
Artigo em Inglês | MEDLINE | ID: mdl-31981869

RESUMO

Particulate organic matter (POM) is a fraction of organic matter with dissimilar properties in different soils. POM isolated from soils and sediments (wetland, oil waste field, farmlands and aquaculture pond sediment) was used to study its sorption behavior on the antibiotic oxytetracycline (OTC). Impacts of solution pH, ionic strength and temperature on the OTC sorption were studied. The sorption rates of OTC in POM from wetland (POM-w) and farmland (POM-f1, POM-f2) were rapid during the first 3 h and gradually decreased with reaction time until reaching the equilibrium. Linear sorption occurred from 3 to 12 h in POM from oil waste field land (POM-o) and aquaculture pond sediment (POM-a). The organic carbon normalized partition coefficient (koc) varied from 215.0 to 4493.6 L kg-1, and it was nearly 10× higher for the POM-w, POM-f1 and POM-f2 than in the POM-o and POM-a. Sorption of OTC by POM exhibited strong pH dependence. Ionic factors affected OTC sorption in POM-f1, POM-f2 and POM-a. The sorption capacity declined >50% in a solution with Ca2+ compared to other ions with similar ionic strength. Sorption thermodynamics showed an entropy increasing and endothermic progress during the OTC sorption in POM, implying a spontaneous sorption process. Several mechanisms were involved in OTC sorption in POM, including hydrogen bonding, cation exchange, hydrophobic partitioning and surface complexation.

19.
Environ Pollut ; 260: 114021, 2020 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-32000028

RESUMO

Hexavalent chromium (Cr(VI)) has significantly threatened the environmental health because of its distinct toxicity. A novel magnetic core-shell structured NZVI@ZD composite was designed for simultaneous adsorption and reduction of Cr(VI). NZVI@ZD was synthesized by carbonization of the as-prepared core-shell structure NZVI@zeolitic imidazole framework-67 (ZIF-67). After carbonization, the original ZIF-67 shell shape was preserved well with marginal parts developing to graphitized carbon. Both cobalt (Co) and NZVI nanoparticles were finely dispersed in the porous ZIF-67 derivative (ZD). NZVI@ZD exhibited excellent removal performance for Cr(VI), owing to its high specific surface area and large pore size favorable for Cr(VI) adsorption and diffusion. The maximum adsorption capacity of NZVI@ZD for Cr(VI) was surprisingly as high as 226.5 mg g-1, surpassing the pristine ZIF-67 (29.35 mg g-1) and NZVI@ZIF-67 (36.53 mg g-1). Zeta potential and X-ray photoelectron spectroscopy (XPS) spectra revealed that electrostatic attraction, reduction and precipitation might be involved in the Cr(VI) removal process by NZVI@ZD, resulting in the conversion of the adsorbed Cr(VI) to Cr(III) of lower toxicity and an eventual immobilization on the NZVI@ZD. The magnetic core-shell structured NZVI@ZD possessed superior adsorptive reactivity for Cr(VI) to most other traditional or newly reported materials, thus should be deemed highly efficient for Cr(VI)-contaminated wastewater treatment.

20.
Heart ; 2020 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-31980439

RESUMO

OBJECTIVE: We aimed to estimate the current use of secondary prevention drugs and identify its associated individual characteristics among those with established cardiovascular diseases (CVDs) in the communities of China. METHODS: We studied 2 613 035 participants aged 35-75 years from 8577 communities in 31 provinces in the China Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project, a government-funded public health programme conducted from 2014 to 2018. Participants self-reported their history of ischaemic heart disease (IHD) or ischaemic stroke (IS) and medication use in an interview. Multivariable mixed models with a logit link function and community-specific random intercepts were fitted to assess the associations of individual characteristics with the reported use of secondary prevention therapies. RESULTS: Among 2 613 035 participants, 2.9% (74 830) reported a history of IHD and/or IS, among whom the reported use rate either antiplatelet drugs or statins was 34.2% (31.5% antiplatelet drugs, 11.0% statins and 8.3% both). Among the 1 530 408 population subgroups, which were defined by all possible permutations of 16 individual characteristics, reported use of secondary prevention drugs varied substantially (8.4%-60.6%). In the multivariable analysis, younger people, women, current smokers, current drinkers, people without hypertension or diabetes and those with established CVD for more than 2 years were less likely to report taking antiplatelet drugs or statins. CONCLUSIONS: The current use of secondary prevention drugs in China is suboptimal and varies substantially across population subgroups. Our study identifies target populations for scalable, tailored interventions to improve secondary prevention of CVD.

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