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1.
Neurosci Lett ; 715: 134596, 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-31711976

RESUMO

The occipital lobe has been implicated in anxiety disorder, however, its contributions to anxiety in healthy adults remain less clear. We conducted a resting-state functional magnetic resonance imaging study to explore the relationship between the amplitude of low-frequency fluctuation (ALFF), functional connectivity (FC), and state anxiety level in the healthy population. First, the results showed that the ALFF of the left inferior occipital gyrus (IOG) was negatively correlated with state anxiety. Furthermore, state anxiety was positively correlated with the FC between the left IOG and the right medial superior frontal gyrus and right cerebellum 8 area and negatively correlated with the FC between the left IOG and the left superior parietal gyrus. These results indicate that the occipital lobe of healthy individuals is involved in processing of anxiety in part through a frontal-parietal network.

2.
J Affect Disord ; 260: 716-721, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31563070

RESUMO

OBJECTIVE: To explore the alterations and value of brain entropy (BEN) in major depressive disorder (MDD). METHODS: 85 MDD patients and 45 matched normal controls were recruited. MDD was diagnosed based on Diagnostic and Statistical Manual of Mental Disorders, 4th ed (DSM-IV). Symptoms of depression were assessed using the Hamilton depression scale-24 (HAMD-24) at baseline and follow-up (after 8-week treatment). All subjects underwent functional magnetic resonance imaging (fMRI) scans at baseline, and 30 MDD patients completed scans at 8th week. Whole brain BEN maps at each session was calculated using the BEN mapping toolbox. RESULTS: The 8-week antidepressant treatment improved symptoms for all MDD patients. As compared to normal controls, MDD showed reduced BEN in medial orbitofrontal cortex (MOFC)/subgenual cingulate cortex (sgACC), but increased BEN in motor cortex (MC). In MDD patients, higher baseline BEN in MOFC/sgACC and lower baseline BEN in temporal cortex (TC) were associated with higher baseline HAMD scores; higher baseline BEN in MOFC/sgACC and hippocampus were associated with greater reduction of HAMD scores after 8-week medication; greater reduction of HAMD scores after 8-week medication was correlated with greater BEN reduction in MOFC/sgACC but were correlated with less BEN reduction in MC, TC, fusiform gyrus (FG) and visual cortex (VC). CONCLUSION: The results highlighted MOFC/sgACC BEN as a potential marker for the prediction of MDD diagnosis and treatment effect. MDD might have increased MOFC/sgACC BEN but reduced BEN in visual and sensory-motor circuits corresponding to the imbalanced emotional and sensory-motor information processing. Reversing this unbalanced BEN would improve disease conditions in MDD.

3.
Front Psychiatry ; 10: 522, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31396115

RESUMO

Background: Altered resting-state functional connectivity of the cerebellum in obsessive-compulsive disorder (OCD) has been previously reported. However, the previous study investigating cerebellar-cerebral functional connectivity relied on a priori-defined seeds from specific networks. In this study, we aimed to explore the connectivity alterations of the cerebellum in OCD under resting-state conditions with a hypothesis-free approach. Methods: Thirty patients with OCD and 26 healthy controls (HCs) underwent functional magnetic resonance imaging (fMRI) scanning at resting state. Regional cerebral function was evaluated by measuring the fraction of amplitude of low-frequency fluctuation (fALFF). Regions with mean fALFF (mfALFF) alterations were used as seeds in seed correlation analysis (SCA). An independent samples t test was used to compare the differences in mfALFF and functional connection (FC) between the two groups. Pearson correlation analysis was performed to identify the association between functional neural correlates and OCD symptom severity evaluated using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Results: Compared with the HC group, the OCD group showed significantly increased mfALFF values in bilateral cerebellar. The results of FC analysis showed weakened connectivity among the left Crus II, lobule VIII, and right striatum and between the right lobule VIII and the right striatum, and cingulate in the OCD group compared with the HC group. Some of the abovementioned results were associated with symptom severity. Conclusions: OCD patients showed abnormal spontaneous cerebellar activity and weakened functional connectivity between the cerebellum and the cortico-striato-thalamo-cortical (CSTC) circuit (striatum and cingulate), suggesting that the cerebellum may play an essential role in the pathophysiology of OCD.

4.
Artigo em Inglês | MEDLINE | ID: mdl-31336382

RESUMO

To identify whether platelet amyloid-ß protein precursor (AßPP) ratio, phosphorylated-tau (P-tau) 231, P-tau181, and serine 396 and 404 (Ser396/404) phosphorylated tau are potential peripheral indicators for early Alzheimer's disease (AD). Forty-three amnesic mild cognitive impairment (aMCI) patients and 45 normal controls were recruited. Peripheral venous blood was drawn and platelets were collected and evaluated for potential indicators by Western blot analysis. Subsequent meta-analysis was completed on these selected indicators. In platelets of aMCI patients, the AßPP ratio level was significantly lower and levels of P-tau231 and Ser396/404 phosphorylated tau were significantly higher. Moreover, in aMCI patients, a negative correlation was observed between platelet P-tau231 level and the Trail Making Tests A score, and it was found that higher platelet P-tau231 levels significantly associated with a worse performance of information processing speed. Furthermore, values of the area under the curve of platelet P-tau231 and Ser396/404 phosphorylated tau were 0.624 and 0.657, respectively. Finally, a meta-analysis indicated platelet AßPP ratio level was significantly lower in MCI cohorts. In conclusion, platelets of aMCI subjects showed a lower AßPP ratio and higher levels of P-tau231 and Ser396/404 phosphorylated tau when compared to normal controls, which may be critical in identifying early AD.

5.
Behav Brain Res ; 371: 111982, 2019 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-31141727

RESUMO

The thalamus plays an important role in pathological mechanisms underlying obsessive-compulsive disorder (OCD). As the thalamus is a heterogeneous brain region, functional connectivity (FC) between thalamic subregions and other brain regions is worth investigating in OCD. In addition, the relationship between abnormal FC and clinical symptoms is still unclear. In this study, we used resting-state functional magnetic resonance imaging to scan 45 OCD patients and 43 well-matched healthy controls (HCs). Thalamic subregions were defined according to the Human Brainnetome Atlas. The fractional amplitude of low-frequency fluctuations (fALFF) and FC seeding-based connectivity were compared using a two-sample t-test. Correlations between abnormal FC and clinical symptoms were analyzed in OCD patients. Compared with HCs, increased fALFF was found in the bilateral thalamus, and increased FC was observed between the right posterior parietal thalamus (PPtha) and left middle occipital gyrus (LMOG) and between the right occipital thalamus (Otha) and right middle occipital gyrus (RMOG) in OCD patients. In addition, OCD patients had reduced FC between the left sensory thalamus (Stha) and left orbital inferior frontal gyrus, right PPtha and left prefrontal cortex, and between the right Otha and left inferior parietal gyrus (LIPG), respectively. Within the OCD group, the FC between right PPtha-LMOG was correlated with severity of clinical symptoms. These results revealed that the FC between the thalamus and occipital lobe is related to obsessive-compulsive symptoms in OCD patients. This finding provides more accurate information about the involvement of the thalamus in the pathophysiology of OCD.

6.
ACS Chem Neurosci ; 10(8): 3479-3485, 2019 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-31145586

RESUMO

The objective of the study was to explore the potential value of plasma indicators for identifying amnesic mild cognitive impairment (aMCI) and determine whether levels of plasma indicators are related to the performance of cognitive function and brain tissue volumes. In total, 155 participants (68 aMCI patients and 87 health controls) were recruited in the present cross-sectional study. The levels of plasma amyloid-ß (Aß) 40, Aß42, total tau (t-tau), and neurofilament light (NFL) were measured using an ultrasensitive quantitative method. Machine learning algorithms were performed for establishing an optimal model of identifying aMCI. Compared with healthy controls, Aß40 and Aß42 levels were lower and NFL levels were higher in plasma of aMCI patients with an exception of t-tau levels. In aMCI patients, the higher plasma Aß40 levels were correlated with the impaired episodic memory and negative correlations were observed between plasma t-tau levels and global cognitive function and gray matter (GM) volume. In addition, the higher plasma NFL levels were correlated with reduced hippocampus volume and total GM volume of the left inferior and middle temporal gyrus. An integrated model included clinical features, hippocampus volume, and plasma Aß42 and NFL and had the highest accuracy for detecting aMCI patients (accuracy, 74.2%). We demonstrated that plasma Aß40, Aß42, t-tau, and NFL may be useful to identify aMCI and correlate with cognitive decline and brain atrophy. Among these plasma indicators, Aß42 and NFL are more valuable as key members of a peripheral biomarker panel to detect aMCI.

8.
Brain Imaging Behav ; 13(4): 1146-1159, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-30054873

RESUMO

Anxiety is the most frequently co-occurring symptom with depression and subsequently contributes to increased severity and treatment resistance in patients with major depressive disorder (MDD). However, little is known about how these two behaviors are linked or interact at the neural network level. Seventy-five unmedicated MDD patients and 42 cognitively normal (CN) subjects underwent resting-state functional magnetic resonance imaging (R-fMRI) and neuropsychological testing. Multivariate linear regression analysis was performed to investigate the neural substrates of anxiety and depression, as well as their interactive effects on the amygdala functional connectivity (AFC) network in MDD patients. In addition, mediation analysis was employed to explore whether intrinsic amygdala connectivity mediates the association between anxiety and depression in patients with MDD. We found that MDD patients suffered symptoms of severe anxiety and a widely reduced functional connectivity in the AFC network, especially in the frontoparietal system and medial temporal lobe. Furthermore, common and distinct neural circuits involving anxiety and depression were separately identified. Interactive analysis revealed that MDD patients with lower HAMA scores showed milder depressive symptoms and greater AFC strength, while those with higher HAMA scores showed more severe depressive symptoms and lower AFC strength. More importantly, mediation analysis suggested that amygdala connectivity strength mediated the relationship between anxiety and depression in MDD patients. These findings extend our understanding of the brain circuitry implicated in MDD patients with comorbid anxiety, and provide new insight into therapeutic targeting of the neural circuits involved in this comorbidity.


Assuntos
Tonsila do Cerebelo/fisiopatologia , Ansiedade/fisiopatologia , Depressão/fisiopatologia , Adulto , Encéfalo/fisiopatologia , Mapeamento Encefálico/métodos , Cognição/fisiologia , Comorbidade , Conectoma/métodos , Transtorno Depressivo Maior/metabolismo , Transtorno Depressivo Maior/fisiopatologia , Feminino , Humanos , Imagem por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Rede Nervosa/metabolismo , Testes Neuropsicológicos , Lobo Temporal/fisiopatologia
9.
Mol Psychiatry ; 2018 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-30413800

RESUMO

Circular RNAs (circRNAs), highly expressed in the central nervous system, are involved in various regulatory processes and implicated in some pathophysiology. However, the potential role of circRNAs in psychiatric diseases, particularly major depressive disorder (MDD), remains largely unknown. Here, we demonstrated that circular RNA DYM (circDYM) levels were significantly decreased both in the peripheral blood of patients with MDD and in the two depressive-like mouse models: the chronic unpredictable stress (CUS) and lipopolysaccharide (LPS) models. Restoration of circDYM expression significantly attenuated depressive-like behavior and inhibited microglial activation induced by CUS or LPS treatment. Further examination indicated that circDYM functions as an endogenous microRNA-9 (miR-9) sponge to inhibit miR-9 activity, which results in a downstream increase of target-HECT domain E3 ubiquitin protein ligase 1 (HECTD1) expression, an increase of HSP90 ubiquitination, and a consequent decrease of microglial activation. Taken together, the results of our study demonstrate the involvement of circDYM and its coupling mechanism in depression, providing translational evidence that circDYM may be a novel therapeutic target for depression.

10.
J Psychiatr Res ; 103: 61-68, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-29783076

RESUMO

Neuroimaging studies have identified that anhedonia, a core feature of major depressive disorder (MDD), is associated with dysfunction in reward and cognitive control processing. However, it is still not clear how the reward network (ß-network) and the cognitive control network (δ-network) are linked to biased anhedonia in MDD patients. Sixty-eight MDD patients and 64 cognitively normal (CN) subjects underwent a resting-state functional magnetic resonance imaging scan. A 2*2 ANCOVA analysis was used to explore the differences in the nucleus accumbens-based, voxelwise functional connectivity (FC) between the groups. Then, the ß- and δ-networks were constructed, and the FC intensities were compared within and between theß- and δ-networks across all subjects. Multiple linear regression analyses were also employed to investigate the relationships between the neural features of the ß- and δ-networks and anhedonia in MDD patients. Compared to the CN subjects, the MDD patients showed synergistic functional decoupling in both the ß- and δ-networks, as well as decreased FC intensities in the intra- and inter- ß- and δ-networks. In addition, the FC in both the ß- and δ-networks was significantly correlated with anhedonia severity in the MDD patients. Importantly, the integrated neural features of the ß- and δ-networks could more precisely predict anhedonic symptoms. These findings initially demonstrated that the imbalance between ß- and δ-network activity successfully predicted anhedonia severity and suggested that the neural features of both the ß- and δ-networks could represent a fundamental mechanism that underlies anhedonia in MDD patients.


Assuntos
Anedonia/fisiologia , Mapeamento Encefálico , Transtornos Cognitivos/etiologia , Transtorno Depressivo Maior/complicações , Transtorno Depressivo Maior/psicologia , Recompensa , Adulto , Transtornos Cognitivos/diagnóstico por imagem , Transtorno Depressivo Maior/diagnóstico por imagem , Feminino , Humanos , Processamento de Imagem Assistida por Computador , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Modelos Neurológicos , Vias Neurais/diagnóstico por imagem , Testes Neuropsicológicos , Escalas de Graduação Psiquiátrica , Estatísticas não Paramétricas
11.
Artigo em Inglês | MEDLINE | ID: mdl-28823848

RESUMO

Psychomotor retardation (PMR) is one of the core symptoms of major depressive disorder (MDD) and has a specific pathophysiology, but studies of PMR remains sparse. The purpose of this study was to explore the cerebral blood flow (CBF) of PMR in MDD. One-hundred-seven antidepressant-free MDD patients and 48 normal controls (NCs) were recruited for this study. All subjects underwent arterial spin labeling-magnetic resonance imaging (ASL-MRI) for the CBF calculation. MDD patients were divided into the PMR group (N=35) and NPMR (non-PMR) group (N=72) according to the Salpetriere Retardation Rating Scale (SRRS) score. After a baseline MRI scan, patients began to receive antidepressant treatment. Thirty-nine patients (15 PMR, 24 NPMR) who were remitted after 8weeks participated in the follow-up MRI scan. For statistical analysis, subjects with unqualified MRI image and unmatched demographic data were ruled out. Consequently, 30 NCs and 60 patients (30 PMR, 30 NPMR) at baseline as well as 22 patients (11 PMR, 11 NPMR) at follow-up underwent statistical analysis. The PMR group showed significantly decreased CBF in the right primary motor cortex (PMC) at baseline, and the CBF value of the right PMC was significantly correlated with the SRRS score, whereas the CBF of the right PMC was increased in the PMR group at follow-up compared with the baseline in longitudinal comparison. Our findings suggest that the CBF of the right PMC is a potential biomarker of PMR in MDD.


Assuntos
Circulação Cerebrovascular , Transtorno Depressivo Maior/fisiopatologia , Córtex Motor/fisiopatologia , Transtornos dos Movimentos/fisiopatologia , Antidepressivos/uso terapêutico , Mapeamento Encefálico , Circulação Cerebrovascular/efeitos dos fármacos , Circulação Cerebrovascular/fisiologia , Estudos Transversais , Transtorno Depressivo Maior/diagnóstico por imagem , Transtorno Depressivo Maior/tratamento farmacológico , Feminino , Seguimentos , Humanos , Estudos Longitudinais , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Córtex Motor/irrigação sanguínea , Córtex Motor/diagnóstico por imagem , Córtex Motor/efeitos dos fármacos , Transtornos dos Movimentos/diagnóstico por imagem , Transtornos dos Movimentos/tratamento farmacológico , Resultado do Tratamento
12.
J Affect Disord ; 225: 539-544, 2018 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-28866298

RESUMO

BACKGROUND: Graph theoretical analyses have identified disrupted functional topological organization across the brain in patients with major depressive disorder (MDD). However, the relationship between brain topology and short-term treatment responses in patients with MDD remains unknown. METHODS: Sixty-eight patients with MDD and 63 cognitively normal (CN) subjects were recruited at baseline and underwent resting-state functional magnetic resonance imaging scans. Graph theory analysis was used to examine group differences in the whole-brain functional topological properties. The association between altered brain topology and the early antidepressant response was examined. RESULTS: Patients with MDD showed lower normalized clustering coefficients, lower small-worldness scalars and increased nodal efficiencies in the default mode network and decreased nodal efficiencies in basal ganglia and hippocampal networks. In addition, the decreased nodal efficiency in left hippocampus was negatively correlated with depressive severity at baseline and positively correlated with changes in the depressive scores after two weeks of antidepressant treatment. LIMITATIONS: The patients in the present study received different medications. CONCLUSION: These findings indicated that the altered brain functional topological organization in patients with MDD is associated with the treatment response in the early phase of medication. Therefore, brain topology assessments might be considered a useful and convenient predictor of short-term antidepressant responses.


Assuntos
Antidepressivos/uso terapêutico , Transtorno Depressivo Maior/diagnóstico por imagem , Transtorno Depressivo Maior/tratamento farmacológico , Hipocampo/diagnóstico por imagem , Adulto , Mapeamento Encefálico , Análise por Conglomerados , Cognição , Feminino , Hipocampo/patologia , Humanos , Imagem por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Vias Neurais/fisiopatologia , Lobo Temporal/fisiopatologia
13.
Front Mol Neurosci ; 10: 292, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28959185

RESUMO

Multiple genetic loci in the dopamine (DA) pathway have been associated with depression symptoms in patients with major depressive disorder (MDD). However, the neural mechanisms underlying the polygenic effects of the DA pathway on depression remain unclear. We used an imaging genetic approach to investigate the polygenic effects of the DA pathway on the reward network in MDD. Fifty-three patients and 37 cognitively normal (CN) subjects were recruited and underwent resting-state functional magnetic resonance imaging (R-fMRI) scans. Multivariate linear regression analysis was employed to measure the effects of disease and multilocus genetic profile scores (MGPS) on the reward network, which was constructed using the nucleus accumbens (NAc) functional connectivity (NAFC) network. DA-MGPS was widely associated within the NAFC network, mainly in the inferior frontal cortex, insula, hypothalamus, superior temporal gyrus, and occipital cortex. The pattern of DA-MGPS effects on the fronto-striatal pathway differed in MDD patients compared with CN subjects. More importantly, NAc-putamen connectivity mediates the association between DA MGPS and anxious depression traits in MDD patients. Our findings suggest that the DA multilocus genetic profile makes a considerable contribution to the reward network and anxious depression in MDD patients. These results expand our understanding of the pathophysiology of polygenic effects underlying brain network abnormalities in MDD.

14.
J Psychiatr Res ; 84: 9-17, 2017 01.
Artigo em Inglês | MEDLINE | ID: mdl-27673704

RESUMO

Neuroimaging studies have demonstrated that major depressive disorder (MDD) patients show blunted activity responses to reward-related tasks. However, whether abnormal reward circuits affect cognition and depression in MDD patients remains unclear. Seventy-five drug-naive MDD patients and 42 cognitively normal (CN) subjects underwent a resting-state functional magnetic resonance imaging scan. The bilateral nucleus accumbens (NAc) were selected as seeds to construct reward circuits across all subjects. A multivariate linear regression analysis was employed to investigate the neural substrates of cognitive function and depression severity on the reward circuits in MDD patients. The common pathway underlying cognitive deficits and depression was identified with conjunction analysis. Compared with CN subjects, MDD patients showed decreased reward network connectivity that was primarily located in the prefrontal-striatal regions. Importantly, distinct and common neural pathways underlying cognition and depression were identified, implying the independent and synergistic effects of cognitive deficits and depression severity on reward circuits. This study demonstrated that disrupted topological organization within reward circuits was significantly associated with cognitive deficits and depression severity in MDD patients. These findings suggest that in addition to antidepressant treatment, normalized reward circuits should be a focus and a target for improving depression and cognitive deficits in MDD patients.


Assuntos
Encéfalo/fisiopatologia , Transtorno Depressivo Maior/fisiopatologia , Transtorno Depressivo Maior/psicologia , Recompensa , Adulto , Encéfalo/diagnóstico por imagem , Mapeamento Encefálico , Transtorno Depressivo Maior/diagnóstico por imagem , Feminino , Humanos , Modelos Lineares , Imagem por Ressonância Magnética , Masculino , Entrevista Psiquiátrica Padronizada , Análise Multivariada , Vias Neurais/diagnóstico por imagem , Vias Neurais/fisiopatologia , Testes Neuropsicológicos , Escalas de Graduação Psiquiátrica , Índice de Gravidade de Doença
15.
J Pharm Pharmacol ; 67(12): 1705-15, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26408267

RESUMO

OBJECTIVES: Our study aimed to investigate the antidepressant-like effect of ethyl acetate extract of the flowers of Campsis grandiflora (EFCG) in a mice model of chronic unpredictable mild stress (CUMS). METHODS: HPLC-Q-TOF-MS was used to identify the chemical constituents of EFCG. The DPPH assay and ABTS radical-scavenging assay were performed to measure the antioxidant properties. The protective properties of EFCG against H2 O2 -induced oxidative damage were analysed in PC12 cells. The changes of behaviour profiles were investigated by using open-field test, sucrose preference test, forced swimming test (FST) and tail suspension test (TST). Brain tissue samples of mice were collected, and antioxidative measure levels were measured. KEY FINDINGS: The result showed that EFCG had the most active anti-oxidative effect and the protective effect against H2 O2 oxidative injury in PC12 cells. Treatment with the EFCG significantly reduced the depressant-like severity and immobility period as compared with untreated CUMS mice in FST and TST. Moreover, EFCG significantly elevated the contents of superoxide dismutase, Glutathione Peroxidase and decreased the contents of Malonaldehyde (MDA) in mice brain. CONCLUSIONS: Our study found first the antidepressant activity of the EFCG. The results suggested the therapeutic potential of EFCG for depressive disorder.


Assuntos
Antidepressivos/farmacologia , Antioxidantes/farmacologia , Comportamento Animal/efeitos dos fármacos , Bignoniaceae/química , Encéfalo/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Extratos Vegetais/farmacologia , Estresse Psicológico/tratamento farmacológico , Acetatos/química , Animais , Antidepressivos/isolamento & purificação , Antioxidantes/isolamento & purificação , Benzotiazóis/química , Compostos de Bifenilo/química , Encéfalo/metabolismo , Cromatografia Líquida de Alta Pressão , Modelos Animais de Doenças , Flores , Preferências Alimentares/efeitos dos fármacos , Masculino , Camundongos , Atividade Motora/efeitos dos fármacos , Células PC12 , Fitoterapia , Picratos/química , Extratos Vegetais/isolamento & purificação , Plantas Medicinais , Ratos , Solventes/química , Espectrometria de Massas por Ionização por Electrospray , Estresse Psicológico/psicologia , Ácidos Sulfônicos/química , Natação
16.
Zhonghua Yi Xue Za Zhi ; 95(47): 3803-7, 2015 Dec 15.
Artigo em Chinês | MEDLINE | ID: mdl-27337794

RESUMO

OBJECTIVE: To investigate the potential association of carbonic anhydrase I (CA1) anterior pharynx-defective 1A ( APH1A), neurodevelopment protein 1-like 1 (NDEL1) and serine racemase (SRR) gene polymorphisms with the susceptibility of schizophrenia (SZ). METHODS: A case-control study was performed to identify polymorphisms of the CA1, APH1A, NDEL1 and SRR gene that may confer susceptibility to SZ in the Han Chinese population. Five single nucleotide polymorphisms (SNPs) were genotyped in 516 paranoid SZ patients and 516 control subjects by real time quantitative polymerase chain reaction. The association between genotypes and positive and negative symptoms scale was also explored. RESULTS: No significant differences in genotype or allele frequencies of five SNPs were observed between schizophrenic patients and healthy controls (P = 0.163, 0.322, 0.494, 0.338, 0.545; 0.259, 0.149, 0.417, 0.527, 0.720; respectively). However, the frequency of CA haplotypes in SZ group was higher than control group (P = 0.041). The scores of depression/anxiety, positive and excited/hostile factors in SZ patients with genotype of rs2298161 (AG), rs4523957 (CC) and rs8081273 (GG) were higher than other genotypes (P = 0.008, 0.001, 0.000, respectively). CONCLUSIONS: These data suggests that the CA1, APH1A, NDEL1 and SRR gene may not be association with susceptibility to SZ in the Han Chinese population. However, the haplotype of CA may be the susceptible factor of SZ. Rs2298161, rs4523957 and rs8081273 may be associated with some phenotypes of SZ.


Assuntos
Estudos de Associação Genética , Predisposição Genética para Doença , Polimorfismo de Nucleotídeo Único , Esquizofrenia/genética , Grupo com Ancestrais do Continente Asiático , Anidrase Carbônica I/genética , Proteínas de Transporte/genética , Estudos de Casos e Controles , China , Endopeptidases , Frequência do Gene , Genótipo , Haplótipos , Humanos , Proteínas de Membrana/genética , Peptídeo Hidrolases/genética , Racemases e Epimerases/genética
17.
BMC Cardiovasc Disord ; 14: 169, 2014 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-25425404

RESUMO

BACKGROUND: Glucose-insulin-potassium (GIK) has been advocated in the setting of acute coronary syndrome (ACS) to reduce ischemia-related arrhythmias and myocardial injury. We conducted a meta-analysis of randomized controlled trials (RCTs) to assess whether the use of GIK infusions >3 or <3 hours after the onset of symptoms reduce mortality or cardiac arrest. METHODS: Electronic databases (Medline, EMBASE, and Cochrane Central Register of Controlled Trials) and references of retrieved articles were searched for RCTs evaluating the effect of GIK infusions, <3 hours or >3 hours after the onset of symptoms, on mortality and/or cardiac arrest. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for each outcome. RESULTS: Nine trials were identified and eligible for review. The summary OR for in-hospital mortality was 1.01 (95% CI 0.94 to 1.09), based on 2,542 deaths among 27,294 patients. The subgroup analysis according to the study enrollment time (within 3 hours [OR, 0.77, 95% CI 0.50-1.16], vs. >3 hours [OR, 0.90; 95% CI, 0.67-1.21]) did not reveal any difference in mortality. CONCLUSIONS: Administration of GIK in ACS patients does not significantly reduce mortality whether or not GIK administration >3 or <3 hours after the onset of symptoms.


Assuntos
Síndrome Coronariana Aguda/tratamento farmacológico , Soluções Cardioplégicas/administração & dosagem , Parada Cardíaca/prevenção & controle , Ensaios Clínicos Controlados Aleatórios como Assunto , Síndrome Coronariana Aguda/complicações , Síndrome Coronariana Aguda/mortalidade , Soluções Cardioplégicas/efeitos adversos , Distribuição de Qui-Quadrado , Esquema de Medicação , Glucose/administração & dosagem , Glucose/efeitos adversos , Parada Cardíaca/etiologia , Parada Cardíaca/mortalidade , Mortalidade Hospitalar , Humanos , Infusões Parenterais , Insulina/administração & dosagem , Insulina/efeitos adversos , Razão de Chances , Potássio/administração & dosagem , Potássio/efeitos adversos , Fatores de Risco , Fatores de Tempo , Tempo para o Tratamento , Resultado do Tratamento
18.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 28(6): 620-4, 2011 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-22161091

RESUMO

OBJECTIVE: To explore the effect of anti-psychotic treatment on the expression of Neuregulin-1 (NRG1) mRNA in the peripheral blood lymphocytes of schizophrenia patients. METHODS: The NRG1 mRNA in peripheral blood lymphocytes was measured using semi-quantitative reverse transcription (RT)-PCR in 80 first-onset schizophrenia patients, 37 sibling controls and 83 non-related controls. The patients were treated with risperdone and quetiapine for 4 weeks. Positive and negative symptom scale (PANSS) was used to evaluate the severity and clinical efficacy. RESULTS: Prior to the treatment, the expression of NRG1 mRNA expression was significantly lower in patients than other two groups (F=73.004, P=0.000). From the second week on, the level of NRG1 mRNA expression in patients became significantly higher than before and gradually increased, whilst no significant difference between sib and non-sib controls. Prior to the treatment, there was significant correlation (r=-0.232, P=0.038) between the level of NRG1 mRNA and PANSS scores. Four weeks after the treatment, a significant correlation between the reduction rate of PANSS and the change of NRG1 mRNA (r=0.27, P=0.016). CONCLUSION: The expression of NRG1 gene mRNA is associated with schizophrenia. Decreased expression of NRG1 may play a role in the development of schizophrenia, which can be improved by anti-psychotic drugs.


Assuntos
Neuregulina-1/genética , Esquizofrenia/genética , Adolescente , Adulto , Antipsicóticos/farmacologia , Antipsicóticos/uso terapêutico , Feminino , Expressão Gênica/efeitos dos fármacos , Regulação da Expressão Gênica/efeitos dos fármacos , Humanos , Masculino , RNA Mensageiro/metabolismo , Esquizofrenia/tratamento farmacológico , Fatores de Tempo , Adulto Jovem
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