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1.
Opt Lett ; 46(22): 5778-5781, 2021 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-34780460

RESUMO

A novel fiber laser called an oscillating-amplifying integrated fiber laser was studied experimentally, in which the oscillating section and amplifying section share the pump between them. Based on this configuration, a 5-kW fiber laser system with optical-optical efficiency of 80.9% and M2 factor of 1.5 was achieved. The startup and shutdown sequence of the laser was studied in detail. When pumps of the laser were deliberately turned on in an inverted order, such as switching on/off the amplifying section before/after the oscillating section, which is normally disastrous in a classic fiber amplifier, the laser system turned out to operate stably at full power level. Thus, it is verified that there is no priority between the amplifier and the seed in this laser system. It combines the advantages of conventional fiber oscillators and fiber amplifiers, including high efficiency, high reliability, good anti-backreflection, and simple control logic.

2.
J Am Chem Soc ; 143(44): 18635-18642, 2021 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-34719924

RESUMO

Encryption is critical to information security; however, existing chemical-based information encryption strategies are still in their infancy. We report here a new approach to chemical encryption involving a supramolecular gel QR (quick response) code with multiple encryption functions. Three color "turn-on" supramolecular polymer gels, G1-G3, were prepared that produce pink, purple, and yellow colors when subject to treatment with acetic acid vapor, UV light, and methanolic FeCl3, respectively. As the result of hydrogen-bonding interactions at the gel interfaces, the three gels can be assembled to produce gel G4. Engraving a QR code pattern onto G4 then gave gel G5. When one or two stimuli are applied to the individual pieces corresponding to the QR engraved versions of the gels G1-G3 making up G5, a complete scannable pattern is not displayed, and the stored information cannot be recognized. Only when three different stimuli are applied at the same time does G5 give a complete recognizable pattern allowing the stored information to be retrieved. This strategy was applied to the decryption-based opening of a coded lock.

3.
Opt Express ; 29(17): 26366-26374, 2021 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-34615073

RESUMO

The transverse mode instability (TMI) has been one of the main limitations for the power scaling of single mode fiber lasers. In this work, we report a 6 kW single mode monolithic fiber laser enabled by effective mitigation of the TMI. The fiber laser employs a custom-made wavelength-stabilized 981 nm pump source, which remarkably enhanced the TMI threshold compared with the wavelength of 976 nm. With appropriately distributing bidirectional pump power, the monolithic fiber laser is scaled to 6 kW with single mode beam quality (M2<1.3). The stability is verified in a continuous operation for over 2 hours with power fluctuation below 1%.

4.
Opt Lett ; 46(19): 5031-5034, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34598262

RESUMO

In this Letter, we propose a scheme to use a temporally stable pump source in a high-power random distributed feedback Raman fiber laser (RRFL) with a half-open cavity. Different from conventional pump manners, the pump source is based on an Yb-doped fiber amplifier, seeded by a temporally stable phase-modulated single-frequency fiber laser for suppressing the spectral broadening and second-order Raman Stokes generation in the output laser. Using a piece of 50-m-long 20/400 µm passive fiber, the maximum output power of 1570 W was obtained with a pump power of 2025 W. The conversion efficiency with respect to the pump power was 77.5%. To the best of our knowledge, this is the highest output power ever reported in a RRFL to date. This work could provide a novel method for power scaling of RRFLs.

5.
Adv Mater ; 33(45): e2105418, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34541727

RESUMO

With the continuous advancement of information technology, the requirements for the information storage capacity of materials are getting higher and higher. However, information code materials usually only store a single piece of information. In order to improve their storage capacity, aggregation-induced emission (AIE) supramolecular adhesive hydrogels with different fluorescent colors are prepared, and a "Codes in Code" method is used to demonstrate the storage capacity for large amounts of information. Four kinds of poly(vinyl alcohol) (PVA) supramolecular hydrogels with different fluorescent colors are prepared; based on the hydrogen bonds on the hydrogel surface, these hydrogels can be assembled into a hydrogel, G5, which shows multiple fluorescent colors under the irradiation of UV light. When many 1D barcode patterns or/and 2D code patterns are incorporated into G5, not only a kind of 3D information but also plenty of 1D or/and 2D information can be stored. Therefore, the information codes prepared by the "Codes in Code" method can store a large amount of information.

6.
Chem Soc Rev ; 50(18): 10025-10043, 2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34346444

RESUMO

Water compatible supramolecular polymers (WCSPs) combine aqueous compatibility with the reversibility and environmental responsiveness of supramolecular polymers. WCSPs have seen application across a number of fields, including stimuli-responsive materials, healable materials, and drug delivery, and are attracting increasing attention from the design, synthesis, and materials perspectives. In this review, we summarize the chemistry of WCSPs from 2016 to mid-2021. For the sake of discussion, we divide WCSPs into five categories based on the core supramolecular approaches at play, namely hydrogen-bonding arrays, electrostatic interactions, large π-conjugated subunits, host-guest interactions, and peptide-based systems, respectively. We discuss both synthesis and polymer structure, as well as the underlying design expectations. The goal of this overview is to deepen our understanding of the strategies that have been exploited to prepare WCSPs, as well as their properties and uses. Thus, a section devoted to potential applications is included in this review.

7.
Opt Lett ; 46(10): 2404-2407, 2021 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-33988594

RESUMO

In this Letter, we report a high-power narrow-linewidth Yb-Raman fiber amplifier with a high second-order Raman threshold and high intensity stability. By employing two temporally stable seed lasers, over 2 kW output power at 1120 nm is achieved at a pump power of 2.6 kW with an optical-to-optical efficiency of 76.3%. The 3 dB linewidth of the 1120 nm Raman-signal laser varies slightly from 0.41 nm to 0.53 nm, and the power ratio of the second-order Raman Stokes light is only about ${-}{46.3}\;{\rm{dB}}$ at the output power of 2 kW. The results further confirm that the technique of employing temporally stable seed lasers is superior to the power scaling of narrow-linewidth Yb-Raman fiber amplifiers. To the best of our knowledge, it is the first demonstration of an over 2 kW narrow-linewidth fiber laser operating at 1120 nm.

8.
Allergy Asthma Clin Immunol ; 17(1): 45, 2021 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-33941235

RESUMO

BACKGROUND: Investigating the endotypes of the different asthma phenotypes would help disease monitoring, prognosis determination, and improving asthma management standardization. This study aimed to classify asthma into four endotypes according to the allergic and eosinophilic characteristics and explore the phenotypes (clinical characteristics, pulmonary functions, and fractional expired nitric oxide (FeNO)) of each endotype. METHODS: This retrospective study included non-acute asthma patients treated at the First Hospital of Shanxi Medical University (05/2016-01/2018). The patients were classified into the eosinophilic allergic, eosinophilic non-allergic, non-eosinophilic allergic, and non-eosinophilic non-allergic asthma endotypes. Serum sIgE, lung function, FeNO, and induced sputum cytology were tested and compared among groups. RESULTS: Of the 171 included patients, 22 had eosinophilic allergic asthma, 17 had eosinophilic non-allergic asthma, 66 had non-eosinophilic allergic asthma, and 66 had non-eosinophilic non-allergic asthma. Lung function measurements (FEV1%, FEF25%, FEF50%, FEF75%, and FEF25-75%) showed that airway dysfunction was worse in eosinophilic non-allergic asthma than in the other three endotypes (all P < 0.001). In allergic asthma patients, eosinophilic asthma had worse airway dysfunction than non-eosinophilic asthma (all P < 0.05). Similar results were found in non-allergic asthma (all P < 0.01). The FeNO levels in eosinophilic allergic asthma were higher than in eosinophilic non-allergic and non-eosinophilic non-allergic asthma (both P = 0.001). CONCLUSIONS: FeNO can objectively reflect eosinophilic airway inflammation in asthma. Endotypic classification of asthma patients regarding the allergic and eosinophilic characteristics is conducive to the effective management of patients with asthma.

9.
BMC Public Health ; 21(1): 460, 2021 03 06.
Artigo em Inglês | MEDLINE | ID: mdl-33676457

RESUMO

BACKGROUND: We investigated the health status of some workers exposed to occupational noise in Xinjiang, and explored the influencing factors of their health level. We aimed to determine the key protection groups of occupational noise hazards, which might provide the basis for the development of targeted noise prevention measures. METHODS: We used descriptive analysis to investigate a total of 11,800 participants who underwent occupational health examination in Xinjiang Occupational Disease Prevention Hospital. RESULTS: The hearing abnormality rate of noise exposure participants was 8.03%, which was higher in males than females (χ2 = 54.507, p < 0.05). The abnormal rate of high-frequency hearing threshold in Xinjiang minorities was lower than in Han nationality (χ2 = 11.780, p < 0.05), while the results of the electrocardiogram were reversed (χ2 = 9.128, p < 0.05). Differences in abnormal rates of blood pressure (χ2 = 149.734, p < 0.05), hearing (χ2 = 231.203, p < 0.05), and physical examination (χ2 = 360.609, p < 0.05) are statistically significant in different industries. The abnormal rates of blood pressure (χ2 = 67.416, p < 0.05) and hearing (χ2 = 49.535, p < 0.05) gradually decrease with the expansion of the enterprise scale. Logistic regression analysis showed that gender, nationality, age, enterprise size, and industry were closely related to pure tone audiometry examination abnormal rate. CONCLUSION: Workers of male, elder, in mine and small/medium enterprises should be the key populations to prevent occupational noise hazard. It is necessary to standardize occupational health management in enterprises, which helps to improve workers' self-protection awareness and quality of life.


Assuntos
Perda Auditiva Provocada por Ruído , Ruído Ocupacional , Doenças Profissionais , Exposição Ocupacional , Saúde do Trabalhador , Idoso , Feminino , Perda Auditiva Provocada por Ruído/diagnóstico , Perda Auditiva Provocada por Ruído/epidemiologia , Perda Auditiva Provocada por Ruído/etiologia , Humanos , Masculino , Ruído Ocupacional/efeitos adversos , Qualidade de Vida
10.
Opt Lett ; 46(6): 1393-1396, 2021 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-33720195

RESUMO

We have demonstrated a 5 kW high-power monolithic fiber amplifier employing a homemade spindle-shaped ytterbium-doped fiber (YDF) based on the main oscillator power amplifier configuration. The YDF consists of a spindle-shaped core and cladding along the fiber length, with a core/cladding diameter of 27/410 µm at both ends and 39.5/600 µm in the middle. An output power of over 5 kW and beam quality of about 1.9 and an optical-to-optical conversion efficiency of 66.6% were achieved in the amplifier under a bidirectional pump scheme. While operating at the maximum power, the laser performance was evaluated, and the transverse mode instability and stimulated Raman scattering effects were well mitigated. To the best of our knowledge, this is the highest power demonstration in a continuous-wave fiber laser employing a tapered fiber. Further power scaling is promising by optimizing the structure of the YDF.

11.
Aging (Albany NY) ; 13(3): 3573-3587, 2021 01 10.
Artigo em Inglês | MEDLINE | ID: mdl-33429365

RESUMO

Inflammation is considered as a key pathogenesis factor of dementia and epilepsy. However, epilepsy's association with dementia, particularly its role in the development of dementia, remains unclear. To evaluate the association between epilepsy and the risk of dementia, in Taiwan, we have now conducted a retrospective cohort study comprising 675 individuals (age, ≥50 years) with epilepsy and 2,025 matched control subjects without epilepsy. In order to match individuals diagnosed with epilepsy with those with no diagnosis of epilepsy (comparison cohort), we utilized exact matching at a ratio of 1:3. Compared with those in the comparison cohort, individuals in the epilepsy cohort had a significantly increased risk of developing dementia (adjusted hazard ratio = 2.87, p < 0.001). A similar result has been observed after stratifying for sex (adjusted hazard ratio in males = 2.95, p < 0.001; adjusted hazard ratio in females = 2.66, p < 0.001). To conclude, based on these data, epileptic individuals ≥50 years were at a greater risk of developing dementia than people who do not have epilepsy, which indicates that a diagnosis of epilepsy presents a greater risk for the development of dementia.


Assuntos
Demência/epidemiologia , Epilepsia/epidemiologia , Idade de Início , Idoso , Idoso de 80 Anos ou mais , Estudos de Casos e Controles , Transtornos Cerebrovasculares/epidemiologia , Estudos de Coortes , Comorbidade , Traumatismos Craniocerebrais/epidemiologia , Depressão/epidemiologia , Feminino , Humanos , Hipertensão/epidemiologia , Hepatopatias/epidemiologia , Masculino , Pessoa de Meia-Idade , Modelos de Riscos Proporcionais , Doença Pulmonar Obstrutiva Crônica/epidemiologia , Estudos Retrospectivos , Fatores de Risco , Taiwan/epidemiologia
12.
Probiotics Antimicrob Proteins ; 13(1): 238-248, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-32529293

RESUMO

Plantaricin BM-1, a class IIa bacteriocin produced by Lactobacillus plantarum BM-1, has significant antibacterial activity against Gram-positive and Gram-negative bacteria. This study aimed to explore the role of the Escherichia coli K12 outer membrane (OM) channel protein TolC in the response to plantaricin BM-1. The tolC null mutant (E. coli K12∆tolC) was constructed by Red homologous recombination. The mechanism of tolC regulating the sensitivity of E. coli K12 under plantaricin BM-1 was investigated. tolC null mutation significantly increased the E. coli K12 sensitivity to plantaricin BM-1 and inhibited biofilm formation, and cells ruptured and shrunk. Proteomic analysis showed that the AcrAB-TolC and EmrAB-TolC efflux pumps were significantly (p < 0.05) upregulated in E. coli K12∆tolC. Based on the results of real-time PCR, we concluded that under plantaricin BM-1, the CpxR/CpxA two-component regulatory system of E. coli K12 responded with envelope damage, followed by activation of the transcription of marA and expression of AcrAB-TolC efflux pump. Moreover, tolC null mutation weakened the AcrAB-TolC efflux pump and then increased the sensitivity of E. coli K12 to plantaricin BM-1. These will contribute exploring the action mechanism of class IIa bacteriocins against Gram-negative bacteria.


Assuntos
Proteínas da Membrana Bacteriana Externa/metabolismo , Proteínas de Bactérias/metabolismo , Bacteriocinas/farmacologia , Farmacorresistência Bacteriana/efeitos dos fármacos , Escherichia coli K12/metabolismo , Proteínas de Escherichia coli/metabolismo , Proteínas de Membrana Transportadoras/metabolismo , Proteínas Quinases/metabolismo , Proteínas da Membrana Bacteriana Externa/genética , Proteínas de Bactérias/genética , Escherichia coli K12/genética , Proteínas de Escherichia coli/genética , Proteínas de Membrana Transportadoras/genética , Proteínas Quinases/genética
13.
Opt Lett ; 45(21): 5949, 2020 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-33137038

RESUMO

This publisher's note contains corrections to Opt. Lett.45, 5792 (2020)OPLEDP0146-959210.1364/OL.404893.

14.
Opt Lett ; 45(20): 5792-5795, 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-33057286

RESUMO

In order to balance the mitigation of transverse mode instability and stimulated Raman scattering effect in the high power fiber lasers, a specially designed Yb-doped fiber, named spindle-shaped Yb-doped fiber, was fabricated with a core/cladding diameter of 20/400 µm at both ends and 30/600 µm in the middle. Based on this fiber, an all-fiber laser oscillator was built and over 3 kW near-single-mode (M2 factor ∼1.3) laser was achieved with an optical-to-optical conversion efficiency of 78.4%. While operating at the maximum power, the transverse mode instability is well mitigated and the stimulated Raman scattering effect is well suppressed (>34dB lower than signal laser). Further power scaling is promising by optimizing the structure of the Yb-doped fiber.

15.
Opt Lett ; 45(13): 3394-3397, 2020 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-32630854

RESUMO

Yb-Raman fiber amplifier (YRFA) is a compact setup that can be applied to achieve high-power narrow linewidth or special wavelength lasers. In this Letter, we realized a high-power YRFA with seed wavelengths of 1090 nm and 1150 nm, tandem-pumped by a 1018 nm fiber laser. The dynamic of mode interaction has been carefully studied. The beam cleanup effect in the large mode area, step-index fiber has been observed for the first time, to the best of our knowledge, when the pump power ranges from 800 W to 1700 W. A model taking into account the Raman mode interaction is proposed to explain this phenomenon, which agrees well with the experiments. The mode instability (MI) effect is also observed in the amplifier, and the threshold is about 2 kW, which is lower than the conventional Yb-doped fiber amplifier. Stimulated Raman scattering is attributed to the onset of MI. Finally, the 1338 W 1150 nm laser is achieved by this YRFA, which we believe to be the highest power reported at this wavelength.

16.
Sci Rep ; 10(1): 9006, 2020 Jun 02.
Artigo em Inglês | MEDLINE | ID: mdl-32488090

RESUMO

In this manuscript, we studied the thermal properties of hundred-watt fiber laser oscillator by real-time in-situ distributed temperature measurement. Optical frequency domain reflectometry (OFDR) was introduced to measure the temperature distribution of gain fiber core. The fiber laser oscillator operated at 1080 nm and the wavelength of detecting signal from OFDR was ~1550 nm. The maximum output power of this fiber oscillator was 100 W. The fiber core temperature distributions in experiment agree well with our theoretical simulation. The temperature measurement of gain fiber core in oscillator has always been a problem because the backward laser from the oscillator may reduce the signal-to-noise ratio in OFDR. To the best of our knowledge, this is the first temperature distribution measurement of fiber core in hundred-watt oscillator. By the experimental measurement and theoretical model, we also analyzed the thermal properties of laser oscillator respectively pumped by 915 nm and 976 nm LD sources. We found fiber laser oscillator pumped by 976 nm LD sources experienced not only higher maximum thermal load but also higher average thermal load than that pumped by 915 nm LD sources at the same level output power. We also analyzed the fiber core temperature of other components in system, such as combiners and fiber Bragg gratings (FBG). These results are meaningful for us to improve the thermal design and management in fiber lasers.

17.
J Food Prot ; 83(10): 1693-1700, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-32421790

RESUMO

ABSTRACT: The quorum-sensing regulation of class II bacteriocin (AcH) synthesis in Lactobacillus plantarum subsp. plantarum Zhang-LL was studied. No detectable inhibition zone was formed by the supernatant of L. plantarum subsp. plantarum Zhang-LL culture in skim milk (SM) with an inoculum size of 7 × 102 CFU/mL after incubation for 36 h. Hence, this culture system was used to investigate the induced regulation mechanism of bacteriocin production in L. plantarum subsp. plantarum Zhang-LL. Bacteriocin production by this bacterium in SM medium was induced by treatment with inactivated culture supernatant from de Man Rogosa Sharpe (MRS) medium (supernatant-MRS). Pediocin AcH encoded by the papA gene in a plasmid in strain Zhang-LL was the inducer present in supernatant-MRS. This is the first report of the role of pediocin AcH in the quorum-sensing regulation of class II bacteriocin synthesis. The mRNA of the papA, papB, papC, and papD genes involved in bacteriocin synthesis by strain Zhang-LL in SM medium was upregulated significantly after being induced by pediocin AcH. This study offers the first evidence that the ABT40_05745, ABT40_05750, and ABT40_11975 components of two-component systems in L. plantarum subsp. plantarum Zhang-LL are involved in the induced regulation of AcH bacteriocin production.


Assuntos
Bacteriocinas , Lactobacillus plantarum , Humanos , Lactobacillus , Lactobacillus plantarum/genética , Pediocinas
18.
Opt Express ; 28(9): 13323-13335, 2020 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-32403810

RESUMO

In this paper, we proposed a temperature modulation technique for the suppression of stimulated Brillouin scattering (SBS). This technique can achieve different kinds of temperature distributions in a high-power laser system with compact design and safe operation. We built up an experiment platform and a theoretical model to evaluate the performance of the temperature modulation technique by applying different temperature distributions along the gain fiber. A total of 3.3 dB SBS suppression can be achieved with only a 70 °C temperature gradient at 36 W output power in this experiment. During the experiment, optical frequency domain reflectometry (OFDR) was used to measure the temperature distributions of the gain fiber core under the effect of the temperature modulation technique. By further simulating and optimizing the temperature distributions, we can see the potential of SBS suppression rise to 3.5 dB with this temperature modulation technique. Through these studies, we demonstrated our temperature modulation technique with high flexibility and great potential for SBS suppression in a high-power single-frequency laser system.

19.
PLoS One ; 15(4): e0231975, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32324803

RESUMO

Plantaricin BM-1 is a class IIa bacteriocin with a strong bactericidal effect on gram-positive bacteria. Although plantaricin BM-1 also inhibits the growth of some gram-negative bacteria, including Escherichia coli, the mechanism is not clear. In this study, we used tandem mass tag-based quantitative proteomics analysis to examine the inhibitory mechanism of plantaricin BM-1 against E. coli K12, and evaluated the morphological effects by electron microscopy. The results demonstrated that plantaricin BM-1 inhibits the growth of E. coli K12 by bacteriostatic action, mainly acting on the surface of the cell wall, leading to its collapse. Proteomic analysis identified 976 differentially expressed proteins (>1.2-fold change, p < 0.05) under treatment with plantaricin BM-1, including 490 up-regulated proteins and 486 down-regulated proteins. These proteins were mainly involved in peptidoglycan synthesis and energy metabolism pathways, including amino acid, glyoxylate and dicarboxylate, ABC transporter, and quorum-sensing pathways. Specifically, plantaricin BM-1 treatment significantly improved peptidoglycan synthesis and enhanced the tricarboxylic acid cycle in E. coli K12, and altered the expression of cell membrane proteins. These results provide new insight into the inhibition mechanism of class IIa bacteriocins on gram-negative bacteria, which can lay the foundation for its broader use as an alternative to conventional antibiotics.


Assuntos
Bacteriocinas/farmacologia , Escherichia coli K12/efeitos dos fármacos , Escherichia coli K12/metabolismo , Peptidoglicano/biossíntese , Proteômica , Escherichia coli K12/crescimento & desenvolvimento , Proteínas de Escherichia coli/metabolismo , Proteínas de Membrana/metabolismo
20.
Proc Natl Acad Sci U S A ; 117(1): 563-572, 2020 01 07.
Artigo em Inglês | MEDLINE | ID: mdl-31871155

RESUMO

Small cell carcinoma of the bladder (SCCB) is a rare and lethal phenotype of bladder cancer. The pathogenesis and molecular features are unknown. Here, we established a genetically engineered SCCB model and a cohort of patient SCCB and urothelial carcinoma samples to characterize molecular similarities and differences between bladder cancer phenotypes. We demonstrate that SCCB shares a urothelial origin with other bladder cancer phenotypes by showing that urothelial cells driven by a set of defined oncogenic factors give rise to a mixture of tumor phenotypes, including small cell carcinoma, urothelial carcinoma, and squamous cell carcinoma. Tumor-derived single-cell clones also give rise to both SCCB and urothelial carcinoma in xenografts. Despite this shared urothelial origin, clinical SCCB samples have a distinct transcriptional profile and a unique transcriptional regulatory network. Using the transcriptional profile from our cohort, we identified cell surface proteins (CSPs) associated with the SCCB phenotype. We found that the majority of SCCB samples have PD-L1 expression in both tumor cells and tumor-infiltrating lymphocytes, suggesting that immune checkpoint inhibitors could be a treatment option for SCCB. We further demonstrate that our genetically engineered tumor model is a representative tool for investigating CSPs in SCCB by showing that it shares a similar a CSP profile with clinical samples and expresses SCCB-up-regulated CSPs at both the mRNA and protein levels. Our findings reveal distinct molecular features of SCCB and provide a transcriptional dataset and a preclinical model for further investigating SCCB biology.


Assuntos
Carcinoma de Células Pequenas/patologia , Carcinoma de Células de Transição/patologia , Transformação Celular Neoplásica/genética , Neoplasias da Bexiga Urinária/patologia , Bexiga Urinária/patologia , Urotélio/patologia , Animais , Antineoplásicos Imunológicos/farmacologia , Antineoplásicos Imunológicos/uso terapêutico , Antígeno B7-H1/antagonistas & inibidores , Antígeno B7-H1/metabolismo , Carcinoma de Células Pequenas/genética , Carcinoma de Células Pequenas/terapia , Carcinoma de Células de Transição/genética , Carcinoma de Células de Transição/terapia , Transformação Celular Neoplásica/efeitos dos fármacos , Células Cultivadas , Cistectomia , Conjuntos de Dados como Assunto , Células Epiteliais , Regulação Neoplásica da Expressão Gênica , Engenharia Genética , Humanos , Linfócitos do Interstício Tumoral/metabolismo , Camundongos , Cultura Primária de Células , RNA-Seq , Bexiga Urinária/citologia , Bexiga Urinária/cirurgia , Neoplasias da Bexiga Urinária/genética , Neoplasias da Bexiga Urinária/terapia , Urotélio/citologia , Ensaios Antitumorais Modelo de Xenoenxerto
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