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Int J Colorectal Dis ; 36(9): 1981-1993, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34322745


PURPOSE: The present study aimed to identify independent clinicopathological and socio-economic prognostic factors associated with overall survival of early-onset colorectal cancer (EO-CRC) patients and then establish and validate a prognostic nomogram for patients with EO-CRC. METHODS: Eligible patients with EO-CRC diagnosed from 2010 to 2017 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were randomly divided into a training cohort and a testing cohort. Independent prognostic factors were obtained using univariate and multivariate Cox analyses and were used to establish a nomogram for predicting 3- and 5-year overall survival (OS). The discriminative ability and calibration of the nomogram were assessed using C-index values, AUC values, and calibration plots. RESULTS: In total, 5585 patients with EO-CRC were involved in the study. Based on the univariate and multivariate analyses, 15 independent prognostic factors were assembled into the nomogram to predict 3- and 5-year OS. The nomogram showed favorable discriminatory ability as indicated by the C-index (0.840, 95% CI 0.827-0.850), and the 3- and 5-year AUC values (0.868 and 0.84869 respectively). Calibration plots indicated optimal agreement between the nomogram-predicted survival and the actual observed survival. The results remained reproducible in the testing cohort. The C-index of the nomogram was higher than that of the TNM staging system (0.840 vs 0.804, P < 0.001). CONCLUSION: A novel prognostic nomogram for EO-CRC patients based on independent clinicopathological and socio-economic factors was developed, which was superior to the TNM staging system. The nomogram could facilitate postoperative individual prognosis prediction and clinical decision-making.

Neoplasias Colorretais , Nomogramas , Neoplasias Colorretais/diagnóstico , Humanos , Estadiamento de Neoplasias , Prognóstico , Programa de SEER
Chem Commun (Camb) ; 49(20): 2046-8, 2013 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-23385347


The catalytic mechanism of doped complex hydrides for hydrogen storage remains unconfirmed. Here, we report a simple method to separate the active species of Ti-based catalysts in NaAlH(4) by filtration using tetrahydrofuran (THF) as solvent. The results show that the average particle size of the obtained Al-Ti active species is 30-50 nm.

Opt Express ; 12(21): 5243-57, 2004 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-19484083


Wavelength modulation imaging (WMI) is capable of determining both spectroscopic and geometrical properties of a target, but the latter is often ignored in spectroscopic studies. This work theoretically and experimentally demonstrates the importance of both in WMI applications. Experiments were performed with an all-digital signal processing approach employing a tunable mid-infrared laser capable of digital wavelength modulation. All three orders of wavelength-derivative images, 0th, 1st, and 2nd are generated simultaneously. Higher order images can reveal or enhance features that are not evident in the 0th order. An example shows a synthetic imaging approach that combines the 2nd order WMI of CO gas with a focal plane array image to allow chemical visualization with minimal background clutter. In another example, fine geometrical features were revealed for a target that has little intrinsic spectroscopic signatures.