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2.
Food Chem ; 397: 133807, 2022 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-35917787

RESUMO

Low-cost wheat by-products have been modified to become an effective delivery system for curcumin. Wheat bran cellulose (WBC) and wheat gluten proteins (WPs) were co-assembled by a pH cycle and addition of sodium tripolyphosphate (STP). Fluorescence spectroscopy and zeta-potential evidenced that the embedding of WBC into the WPs favored the formation composites a relative unfolding state. Modifying the nanocomposite with STP lowered the Dh and PDI of the co-assembled structure. The nanocomplexes had a typical core-shell structure according to TEM characterization, where proteins aggregate to form a hydrophobic core and the hydrophilic WBC and STP crosslinked to form the shell. To improve the bioavailability of curcumin, it was encapsulated in WWBCs composites by participating in their structural co-assembly. In vitro simulated gastrointestinal digestion experiments showed that the curcumin encapsulated in WWBCs possessed gastrointestinal slow and controlled release function, with a final release of curcumin of 77.8 ± 2.3 %.

3.
Ann Transl Med ; 10(13): 741, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35957730

RESUMO

Background: Surface-based cortical morphological patterns provide insight into the neural mechanisms of Parkinson's disease (PD). Explorations of the relationship between these patterns and the clinical assessment and treatment effects could be used to inform early intervention and treatment planning. Methods: We recruited 78 PD patients who underwent presurgical evaluation and 55 healthy controls. We assessed neocortical sulcal depth, gyrification index, and fractal dimension and applied a general linear model using the multivariate Hotelling's t-test to determine the joint effect of surface-based shape abnormalities in PD. The relationship between the neuroimaging pattern and clinical assessment was investigated using a multivariate linear regression model. A machine learning model based on surfaced-based features was used to predict responses to medication and deep brain stimulation (DBS). Results: The surface-based neuroimaging pattern of PD included decreases in morphological metrics in the gyrus (left: F=4.32; right: F=4.13), insular lobe (left: F=4.87; right: F=4.53), paracentral lobe (left: F=4.01; right: F=4.26), left posterior cingulate cortex (F=4.48), and left occipital lobe (F=4.27, P<0.01). This pattern was significantly associated with cognitive performance and motor symptoms (P<0.01). The machine learning model using morphological metrics was able to predict the drug response in the tremor score (R=-0.34, P<0.01) and postural instability and gait disorders score (R=0.24, P=0.04). Conclusions: We identified the surface-based neuroimaging pattern associated with PD and explored its association with clinical assessment. Our findings suggest that these morphological indicators have potential value in informing personalized medicine and patient management.

4.
Front Surg ; 9: 841680, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35937609

RESUMO

This study aims to analyze the potential association between the preoperative coagulation status and perioperative blood loss in spinal deformity correction surgery. The preoperative coagulation status and estimated blood loss (EBL) during operation, postoperative wound drainage, and allogeneic transfusion during and after operation were recorded and analyzed. Among the 164 patients, 26 had a longer prothrombin time (PT), 13 had a lower fibrinogen level, 55 had a longer activated partial thromboplastin time (APTT), and 2 had a longer thrombin time (TT), and the platelet count (PLT) was all normal or higher than the normal level. The mean EBL per surgical level was 77.8 ml (range, 22-267 ml), and the mean drainage per surgical level was 52.7 ml (range, 7-168 ml). Fifty-five patients and 12 patients underwent allogeneic transfusion during and after the operation, respectively. The differences in EBL per surgical level, mean drainage per surgical level, the occurrences of allogeneic transfusion during and after operation between the patients with a longer PT, lower fibrinogen level, longer APTT or longer TT, and the normal controls were not significant (all P's > 0.05). The Spearman correlation analysis showed that there was no correlation between PT, fibrinogen, APTT, TT or PLT with EBL per surgical level, mean drainage per surgical level, or allogeneic transfusion during and after the operation (all P's > 0.05). The abnormal preoperative coagulation status but not hemophilia does not lead to more perioperative blood loss or a higher rate of perioperative allogeneic transfusion in spinal deformity correction surgery.

5.
Cancer Lett ; 545: 215852, 2022 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-35926817

RESUMO

Small cell lung cancer (SCLC) is a highly malignant tumor with extremely poor prognosis. The treatment strategy is very limited, and patient outcomes remain dismal with the 5-year survival rate being mere 3-6%. Thus, novel therapeutic strategies for SCLC patients are urgently needed. In this study, we found that the triple-therapy of poly (ADP-ribose) polymerase (PARP) inhibitor, radiotherapy (RT) and anti-PD-1 treatment significantly inhibited tumor growth and prolonged survival in the syngeneic SCLC models in immunocompetent C57BL/6 mice. Mechanistically, we demonstrated that the combination of PARP inhibitor niraparib and RT reshaped an inflamed tumor microenvironment, including activation of the cGAS/STING immune response pathway, induction of immunogenic cell death, and upregulation of PD-L1 on tumor cells. Furthermore, this triple-therapy substantially augmented CD8+ T cell infiltration and activation, and enhanced anti-tumor effects as revealed by increased median survival time and reduced tumor volume without additional myelosuppression or hepatic injury. Together, our studies demonstrated that PARP inhibitor combined with RT potentiated anti-tumor immunity and enhanced the efficacy of anti-PD-1 immunotherapy in preclinical study, which provided a promising therapeutic strategy for SCLC patients in clinic.

6.
Artigo em Inglês | MEDLINE | ID: mdl-35917052

RESUMO

PURPOSE: For estrogen receptor (ER)-positive breast cancer, neoadjuvant endocrine therapy (NET) has been shown to be as effective as neoadjuvant chemotherapy (NACT). We evaluated the prognostic significance of Preoperative Endocrine Prognostic Index (PEPI). METHODS: We conducted a prospective, multi-center, non-randomized, controlled trial that enrolled postmenopausal early-stage strongly ER-positive (≥ 50%) and HER2-negative breast cancer patients. All patients were given 4-month NET before surgery. The primary objective was to investigate the 5-year recurrence-free survival (RFS) in patients who had PEPI 0-1 or pathological complete response (pCR) without chemotherapy. Patients who had PEPI 0-1 or pCR were recommended to receive adjuvant endocrine therapy only and patients had PEPI ≥ 2 may receive adjuvant chemotherapy at the discretion of the treating physician. RESULTS: A total of 410 patients were included and 352 patients constituted the per-protocol population. Overall, 9 patients (2.5%) had pCR (ypT0/is ypN0), 128 patients (36.4%) had PEPI = 0, and 56 patients (15.9%) had PEPI = 1. After a median follow-up of 60 months (4-104 months), patients who had PEPI 0-1 or pCR showed an improved 5-year RFS [99.5% (95% CI 98.5-99.9%) for PEPI 0-1 or pCR group vs. 93.7% (95% CI 89.6-97.8%) for PEPI ≥ 2 group, P = 0.028]. No survival difference was detected between patients received adjuvant chemotherapy vs. no chemotherapy among PEPI ≥ 2 cases. CONCLUSION: PEPI 0-1 or pCR may be used to define a group of ER-positive and HER2-negative postmenopausal early breast cancer patients with low relapse risk for whom adjuvant chemotherapy can be safely withheld. Studies on the identification and alternative treatment options for endocrine-resistant tumors are warranted. CLINICAL TRIAL REGISTRATION: NCT01613560.

7.
World Neurosurg ; 2022 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-35787958

RESUMO

OBJECTIVE: The purpose of this study was to investigate differences between measurements of spine on two-dimensional (2D) radiography and three-dimensional (3D) computed tomography (CT) images taken of patients with adolescent idiopathic scoliosis. METHODS: Standard preoperative CT images and posteroanterior (PA) and lateral radiography images were collected prospectively from 43 patients with adolescent idiopathic scoliosis in whom selective spinal fusions were performed. The parameters of interest were the thoracic Cobb angle, lumbar Cobb angle, T4-T12 kyphosis angle, and L1-S1 lordosis (LL) angle. The parameters were measured using 3 separate methods: 3D measurement of CT images (3D measurement), 2D measurement of radiography images (2D measurement), and 2D measurement of radiography images generated by the projection of CT images (2D XP measurement). Significant differences among the results were assessed by comparison T test. RESULTS: The mean difference between the 2D and 2D XP measurements for the thoracic Cobb, lumbar Cobb, T4-T12 kyphotic, and L1-S1 lordotic angles was 8.38°, 7.67°, 8.77°, and 10.18°, respectively. The mean difference between the 2D XP and 3D measurements was -2.81°, -2.78°, -1.29°, and -2.36°, respectively. The mean difference between the 2D and 3D measurements was 5.16°, 4.51°, 6.49°, and 7.37°, respectively. The results showed significant differences (P < 0.05) among the spinal parameters measured using the 2D, 2D XP, and 3D measurement methods on both the coronal and sagittal plane. CONCLUSIONS: Significant differences among the 2D, 2D XP, and 3D measurement methods were observed on both the sagittal plane and coronal plane of the scoliotic spines as a result of variations in posture during imaging and differences in measurement methods.

8.
Global Spine J ; : 21925682221117130, 2022 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-35862230

RESUMO

STUDY DESIGN: Retrospective Aanalysis of a Large Cohort of Cases. OBJECTIVES: To explore the rate and cause of revision surgery after spinal fusion in adolescent idiopathic scoliosis(AIS). METHODS: The patients diagnosed with AIS who underwent spinal fusion surgery in a single center from 2002 to 2018 were retrospectively analyzed. All the patients were followed up at least 2 years. The causes of revision surgery were analyzed and the incidence of revision surgery was counted. RESULTS: A total of 1816 AIS patients were included in the study. After an average of 8.5 years (range 3-18 years) follow-up, a total of 51 patients underwent 54 revision operations. The overall revision rate is 2.8%. The revision rate of combined approach (anterior and posterior) and anterior approach was 6.6% (8/122), and the revision rate of posterior approach was 2.5% (43/1694). The most common causes of revision were malposition of implants/implants failure (37%), followed by poor wound healing/ infection (23%). Spinal decompensation, adding on and proximal junctional kyphosis (PJK) accounted for 20%. The compensatory curve continued to worsen after selective fusion accounted for 14% and finally the discomfort with the implants accounted for 6%. CONCLUSIONS: The overall revision rate of spinal fusion for AIS is 2.8%. The implants and incision problems were the most common causes of revision surgeries.

9.
Int J Clin Pract ; 2022: 6924489, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35832798

RESUMO

Background: Thoracic surgery is one of the most painful surgical steps. An important tool for managing postoperative pain is effective postoperative analgesia. This research aimed at comparing the analgesic roles of three new fascial block techniques in the postoperative period after video-helped thoracoscopic operation (VATS). Methods: We randomly allocated ninety patients into three teams experiencing ultrasound-directed serratus plane block, erector spinae plane block, and the rhomboid intercostal block, respectively. 0.4% ropivacaine of 20 mL was received by all groups. Outcomes. At 0-12 hours, sufentanil consumption was significantly lower in the RIB (35.2 ± 3.3 mg) and ESP (35.4 ± 2.8 mg) groups than that in the SAB (43.3 ± 2.7 mg) group (P < 0.001), and no obvious diversity in sufentanil consumption was shown between the RIB and ESP groups (P=0.813). At 12-24 hours, sufentanil consumption was greatly lower in the RIB and ESP groups than that in the SAB group (P < 0.001), and no great diversity in sufentanil consumption was found between the RIB and ESP groups (P=0.589). No great diversity in sufentanil consumption was shown between the RIB (50.4 ± 1.4 mg), ESP (50.4 ± 1.5 mg), and SAB (51.0 ± 1.7 mg) groups at 24-48 hours (P=0.192). At 6, 12, 18, and 24 hours, the postoperative dynamic NRS scores were significantly lower in the RIB and ESP groups than in the SAB group ((P < 0.05) for all contrasts). Nevertheless, no great diversity was observed in postoperative pain marks at 0.5, 1, 3, 6, 12, 18, 24, 36, and 48 hours after the surgery across the three groups. No statistical diversity was found in the postoperative NRS mark between groups RIB and ESP within 48 hours after surgery in case of active patients ((P < 0.05) for all contrasts). At 24 hours after surgery, a significant difference in IL-1ß and IL-6 inflammatory factor concentrations was found between RIB and ESP compared with SAB block ((P < 0.05) for all contrasts). However, no great diversities were observed in IL-1ß, and IL-6 inflammatory factor concentrations between RIB, ESP, and SAB at 24 hours preoperatively and at 48 hours postoperatively ((P < 0.05) for all comparisons). Conclusion: The dosage of sufentanil can be effectively reduced by ultrasound-directed rhomboid intercostal block and erector spinae plane block within 24 hours after VATS surgery, and pain can be relieved effectively within 24 hours by comparing with serratus plane block.


Assuntos
Analgesia , Bloqueio Nervoso , Analgesia/métodos , Analgésicos Opioides , Humanos , Interleucina-6 , Bloqueio Nervoso/métodos , Medição da Dor , Dor Pós-Operatória/prevenção & controle , Estudos Prospectivos , Sufentanil , Cirurgia Torácica Vídeoassistida , Ultrassonografia de Intervenção/métodos
10.
Commun Biol ; 5(1): 663, 2022 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-35790819

RESUMO

The purpose of this study is to examine the association between G protein-coupled receptor 87 (GPR87) and lung adenocarcinoma (LUAD) metastasis and immune infiltration. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets extract clinical data. According to the TCGA database, increased GPR87 expression predicts poor overall survival, progression-free interval, and disease-specific survival in LUAD patients. The meta-analysis also reveals a significant association between high GPR87 expression and poor overall survival. Moreover, functional experiments demonstrate that GPR87 silencing reduces LUAD cell invasion and migration. Immunoblotting shows that GPR87 knockdown decreased Vimentin and N-cadherin expression and increased E-cadherin expression in LUAD cells. GPR87 expression in LUAD is positively correlated with immune infiltration. In addition, GPR87 expression is associated with immune and chemotherapy resistance in LUAD patients. Our findings indicate that GPR87 promotes tumor progression and is correlated with immune infiltration, suggesting GPR87 as a possible biomarker for prognosis prediction in LUAD.


Assuntos
Adenocarcinoma de Pulmão , Adenocarcinoma , Neoplasias Pulmonares , Adenocarcinoma/metabolismo , Adenocarcinoma de Pulmão/genética , Adenocarcinoma de Pulmão/metabolismo , Regulação Neoplásica da Expressão Gênica , Humanos , Neoplasias Pulmonares/patologia , Processos Neoplásicos , Receptores de Ácidos Lisofosfatídicos/genética , Receptores de Ácidos Lisofosfatídicos/metabolismo
11.
12.
Front Genet ; 13: 911369, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35846127

RESUMO

Background: Non-invasive prenatal diagnosis (NIPD) can identify monogenic diseases early during pregnancy with negligible risk to fetus or mother, but the haplotyping methods involved sometimes cannot infer parental inheritance at heterozygous maternal or paternal loci or at loci for which haplotype or genome phasing data are missing. This study was performed to establish a method that can effectively recover the whole fetal genome using maternal plasma cell-free DNA (cfDNA) and parental genomic DNA sequencing data, and validate the method's effectiveness in noninvasively detecting single nucleotide variations (SNVs), insertions and deletions (indels). Methods: A Bayesian model was developed to determine fetal genotypes using the plasma cfDNA and parental genomic DNA from five couples of healthy pregnancy. The Bayesian model was further integrated with a haplotype-based method to improve the inference accuracy of fetal genome and prediction outcomes of fetal genotypes. Five pregnancies with high risks of monogenic diseases were used to validate the effectiveness of this haplotype-assisted Bayesian approach for noninvasively detecting indels and pathogenic SNVs in fetus. Results: Analysis of healthy fetuses led to the following accuracies of prediction: maternal homozygous and paternal heterozygous loci, 96.2 ± 5.8%; maternal heterozygous and paternal homozygous loci, 96.2 ± 1.4%; and maternal heterozygous and paternal heterozygous loci, 87.2 ± 4.7%. The respective accuracies of predicting insertions and deletions at these types of loci were 94.6 ± 1.9%, 80.2 ± 4.3%, and 79.3 ± 3.3%. This approach detected pathogenic single nucleotide variations and deletions with an accuracy of 87.5% in five fetuses with monogenic diseases. Conclusions: This approach was more accurate than methods based only on Bayesian inference. Our method may pave the way to accurate and reliable NIPD.

13.
Artigo em Inglês | MEDLINE | ID: mdl-35881246

RESUMO

Komagataella phaffii (K. phaffii) is a famous microbial cell of heterologous protein and value-added chemicals production because of its strict and strong promoter (alcohol oxidase 1 promoter, PAOX1). Formate is an attractive substitute of traditional inducer methanol because methanol is toxic and explosive. To obtain high level of Aspergillus niger ATCC1015 xylanase as a model of heterologous protein by K. phaffii at formate induction, insertion of three-copy cis-acting element W3A into PAOX1 additionally, and co-expression of transcription factor Mit1 under another PAOX1 were carried out separately and simultaneously. The yield of xylanase increased by 41% at formate induction when Mit1 was co-expressed. Furtherly, the yield of xylanase increased by 42% using sorbitol as supplemental carbon source with the result of 408.3 × 103 U‧L-1 xylanase. Therefore, a non-methanol needed and inducible heterologous protein expression system of Komagataella phaffii was developed successfully.

14.
ACS Appl Mater Interfaces ; 14(28): 32084-32095, 2022 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-35819052

RESUMO

Alkali and alkaline-earth metal salts with 3,4-dinitropyrazole (DNP) were synthesized by the reaction of DNP with stoichiometric amounts of the corresponding metal hydroxide-, oxide-, or carbonate-based highly pure salts, and products were fully characterized. Determination of single-crystal structures of all new complexes except for the lithium and strontium salts was performed by X-ray diffraction techniques. The cesium salt crystallized no water among them. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) manifested that these salts have satisfactory thermal stabilities with decomposition temperatures above 210 °C. They also showed that there exists strong bonding of crystallized water among lattices, which disappeared at temperatures equal to or above 115 °C except for salts MES-3, MES-4, and MES-9. In addition, the percentage of water contents was confirmed by using DSC and TGA methods. The constant-volume combustion heats of these metal salts containing DNP anions were measured using an oxygen bomb calorimeter due to their expectant interest in energetic materials, and their standard molar formation enthalpies were obtained. The investigated salts were found to be insensitive toward friction and impact. Findings of burning tests performed with experimental formulations using MES-1, MES-7, MES-8, and MES-9 certify that these four salts might be more promising candidates for application in green pyrotechnics.

15.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 53(4): 559-563, 2022 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-35871723

RESUMO

Neuromodulation technology is one of the medical fields currently experiencing the most rapid development, witnessing a surge in the types of modulation techniques and a constant expansion of indications. Consequently, hundreds of thousands of patients with functional neurological disorders have benefited from the advancements in the field all over the world. Nevertheless, some challenges remain, for exmaple, the lack of a thorough understanding of the mechanism of neuromodulation, the long-standing controversy over the optimal targets of neuromodulation, the lack of reliable efficacy predictors, and the cumbersome and inefficient mode of postoperative programming. We anticipate that these issues will be resolved with the continued advancement in medical technology and the gradual revelation of the neural network mechanism of brain disorders. More individualized, precise, and intelligent neuromodulation technology will be the main direction of development in the future. Herein, we reviewed and commented on the evolution of neuromodulation technology, the current status of its applications, and its prospective development.


Assuntos
Terapia por Estimulação Elétrica , Terapia por Estimulação Elétrica/métodos , Humanos , Estudos Prospectivos
16.
J Radiat Res ; 2022 Jul 11.
Artigo em Inglês | MEDLINE | ID: mdl-35818292

RESUMO

Brachytherapy has the advantages of being minimally invasive and highly conformal, and it achieves good results in head and neck tumors. To precisely implant the radioactive seeds according to the preplan in deep head and neck regions, the surgical navigation is applied. This study aims to explore the clinical application and accuracy of imaging-based surgical navigation-guided 125I interstitial brachytherapy in terms of seed position. We included 41 patients with tumors in deep head and neck regions. The brachytherapy treatment plan was designed, and the preplanned data were transferred to the navigation system. Needle implantation and seed delivery were performed under surgical navigation system guidance with or without the combination of individual template. The treatment accuracy was evaluated by comparing seed cluster locations between the preoperative treatment plan and the postoperative treatment outcome. A total of 2879 seeds were delivered. The range, mean and median distances between the geometric centers of the preoperative seed point clusters and the postoperative seed point clusters were 0.8-10.5 mm, 4.5 ± 2.3 mm and 4.1 mm, respectively. The differences between preoperative and postoperative volumes of the minimum bounding box of seed point clusters were nonsignificant. In conclusion, the imaging-based surgical navigation system is a promising clinical tool to provide the preplanned data for interstitial brachytherapy intraoperatively, and it is feasible and accurate for the real-time guidance of needle implantation and seed delivery in deep head and neck regions.

17.
CNS Neurosci Ther ; 28(9): 1380-1392, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35687507

RESUMO

BACKGROUND/AIMS: The efficacy and safety of posterior subthalamic area (PSA) and ventral intermediate nucleus (VIM) deep brain stimulation (DBS) in the treatment of essential tremor (ET) have not been compared in large-scale studies. We conducted a secondary analysis to identify the superior target of ET-DBS treatment. METHODS: PubMed, Embase, Cochrane Library, and Google Scholar were searched for relevant studies before September 2021. The tremor-suppression efficacy and rate of stimulation-related complications (SRCR) after PSA-DBS and VIM-DBS treating ET were quantitatively compared. Secondary outcomes, including tremor subitem scores and quality of life results, were also analyzed. Subgroup analyses were further conducted to stratify by follow-up (FU) periods and stimulation lateralities. This study was registered in Open Science Framework (DOI: 10.17605/OSF.IO/7VJQ8). RESULTS: A total of 23 studies including 122 PSA-DBS patients and 326 VIM-DBS patients were analyzed. The average follow-up time was 12.81 and 14.66 months, respectively. For the percentage improvement of total tremor rating scale (TRS) scores, PSA-DBS was significantly higher, when compared to VIM-DBS in the sensitivity analysis (p = 0.030) and main analysis (p = 0.043). The SRCR after VIM-DBS was higher than that of PSA-DBS (p = 0.022), and bilateral PSA-DBS was significantly superior to both bilateral and unilateral VIM-DBS (p = 0.001). CONCLUSIONS: This study provided level IIIa evidence that PSA-DBS was more effective and safer for ET than VIM-DBS in 12-24 months, although both PSA-DBS and VIM-DBS were effective in suppressing tremor in ET patients. Further prospective large-scale randomized clinical trials are warranted in the future.


Assuntos
Estimulação Encefálica Profunda , Tremor Essencial , Estimulação Encefálica Profunda/métodos , Tremor Essencial/terapia , Humanos , Qualidade de Vida , Resultado do Tratamento , Tremor , Núcleos Ventrais do Tálamo
18.
Neuroimage ; 258: 119389, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-35714885

RESUMO

Low-frequency oscillations (LFOs, 28 Hz) in the subthalamic nucleus(STN) are known to reflect cognitive conflict. However, it is unclear if LFOs mediate communication and functional interactions among regions implicated in conflict processing, such as the motor cortex (M1), premotor cortex (PMC), and superior parietal lobule (SPL). To investigate the potential contribution of LFOs to cognitive conflict mediation, we recorded M1, PMC, and SPL activities by right subdural electrocorticography (ECoG) simultaneously with bilateral STN local field potentials (LFPs) by deep brain stimulation electrodes in 13 patients with Parkinson's disease who performed the arrow version of the Eriksen flanker task. Elevated cue-related LFO activity was observed across patients during task trials, with the earliest onset in PMC and SPL. At cue onset, LFO power exhibited a significantly greater increase or a trend of a greater increase in the PMC, M1, and STN, and less increase in the SPL during high-conflict (incongruent) trials than in low-conflict (congruent) trials. The local LFO power increases in PMC, SPL, and right STN were correlated with response time, supporting the notion that these structures are critical hubs for cognitive conflict processing. This power increase was accompanied by increased functional connectivity between the PMC and right STN, which was correlated with response time across subjects. Finally, ipsilateral PMC-STN Granger causality was enhanced during high-conflict trials, with direction from STN to PMC. Our study indicates that LFOs link the frontal and parietal cortex with STN during conflicts, and the ipsilateral PMC-STN connection is specifically involved in this cognitive conflict processing.


Assuntos
Estimulação Encefálica Profunda , Doença de Parkinson , Núcleo Subtalâmico , Conflito Psicológico , Humanos , Lobo Parietal
19.
Dalton Trans ; 51(25): 9894-9904, 2022 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-35722662

RESUMO

Two bimetallic complexes of 4-hydroxy-3,5-dinitropyrazole, [K2Mn(DNPO)2(H2O)4]n·2H2O (BMEP-1) and [K2Zn(DNPO)2(H2O)6]n (BMEP-2), were synthesized and characterized by IR spectroscopy and elemental analysis. The crystal structures of BMEP-1 and BMEP-2 were determined by single-crystal X-ray diffraction. It is noteworthy that these complexes presented different metal-organic frameworks. The thermal behaviors of BMEP-1 and BMEP-2 were investigated by differential scanning calorimetry and thermogravimetric analysis measurements. These bimetallic complexes exhibited high thermal stability (348.0 °C and 331.0 °C) due to their large coordination bonds and three-dimensional interconnected structure. The catalytic performances of BMEP-1 and BMEP-2 on the thermal decomposition of ammonium perchlorate were investigated by TGA-DSC, TGA-FTIR, and non-isothermal kinetic analyses. The results showed that BMEP-1 and BMEP-2 exhibited excellent catalytic performance in the thermal decomposition of ammonium perchlorate. Notably, there was only a single exothermic peak at 302.6 °C and 318.6 °C, and the activation energy values of ammonium perchlorate decreased to 123.88 kJ mol-1 and 128.43 kJ mol-1, respectively. TGA-FTIR results showed that BMEP-1 and BMEP-2, as effective components of catalysis, will promote the production of H2O, N2O, NO2, and HCl in advance, during the thermal decomposition of ammonium perchlorate. BMEP-1 and BMEP-2 are expected to be two candidate additives for the catalytic decomposition of ammonium perchlorate in composite solid propellants.

20.
Artigo em Inglês | MEDLINE | ID: mdl-35653446

RESUMO

Information security occupies a very important part of national security. Chaos communication can provide high-level physical layer security, but its harsh claims on the chaotic system parameters of the transmitter and the receiver resulting in reduced synchronization coefficient and more difficult consistent synchronization of point to multipoint networking. In this article, a chaotic synchronization and communication system based on reservoir computing (RC) has been proposed. In this scheme, the trained RC highly synchronized with the emitter acts as the receiver with simplified structure under the premise of ensuring safety. Simultaneously, the cross-prediction algorithm has been proposed to weaken the accumulation effect of prediction synchronization error of RC and facilitate the realization of long-term communication. Furthermore, the tolerance of the system performance to the signal-to-noise ratio with the variations of the mask coefficients has been investigated, and the optimal operation point under the condition of the adjustable number of nodes and leakage rate of RC has been numerically analyzed. The simulation results show that the normalized mean-square error of synchronization of 10⁻6 magnitude and the bit error rate of decryption at 10⁻8 level can be obtained. Finally, from the operational perspective, a 100-m short-distance experiment confirms that its communication performance is consistent with the simulation results. We strongly believe that the proposed system offers the opportunity of a new research direction in chaotic secure communications.

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