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1.
J Hazard Mater ; 381: 121208, 2019 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-31563672

RESUMO

Contaminated mining sites require ecological restoration work, of which phytoremediation using appropriate plant species is an attractive option. Our present study is focused on one typical contaminated mine site with indigenous plant cover. The X-ray absorption near edge structure (XANES) analysis indicated that Cu (the major contaminant) was primarily associated with goethite (adsorbed fraction), with a small amount of Cu oxalate-like species (organic fraction) in mine affected soil. With growth of plant species like Miscanthus floridulus and Stenoloma chusanum, the Cu-oxalate like organic species in rhizosphere soil significantly increased, with corresponding decrease in Cu-goethite. In the root cross-section of Miscanthus floridulus, synchrotron-based micro-X-ray fluorescence (µ-XRF) microscopy and micro-XANES results indicated that most Cu was sequestered around the root surface/epidermis, primarily forming Cu alginate-like species as a Cu-tolerance mechanism. From the root epidermis to the cortex and vascular bundle, more Cu(I)-glutathione was observed, suggesting reductive detoxification ability of Cu(II) to Cu(I) during the transport of Cu in the root. The observation of Cu-histidine in root internal cell layers showed another Cu detoxification pathway based on coordinating amino ligands. Miscanthus floridulus showed ability to accumulate phosphorous and nitrogen nutrients in rhizosphere and may be an option for in situ phytostabilization of metals in contaminated mining area.

2.
Disabil Rehabil ; : 1-9, 2019 Aug 22.
Artigo em Inglês | MEDLINE | ID: mdl-31437066

RESUMO

Purpose: To describe the perceived participation and assess its determinants among young and middle-aged stroke patients following acute care one month after discharge in mainland China. Methods: Two hundred and twenty-three patients were consecutively recruited from two tertiary hospitals and were followed up 1 month after discharge in the outpatient department or their communities to assess their participation by using the Impact on Participation and Autonomy Questionnaire, with 23 patients lost to follow-up. Determinants (i.e., sociodemographic, diseased-related, physical, psychological, and social factors) of participation were identified in four domains: indoor autonomy; outdoor autonomy; family role; and social life. Results The overall perceived participation of our respondents was good to fair. Forty-six (23.0%), 32 (16.0%), 13 (6.5%), and 19 (9.5%) perceived their participation as "very good" in the domains of indoor autonomy, family role, outdoor autonomy and social life, respectively. Stroke severity, depressive symptoms, and social support were the common determinants of participation for all the domains, with stroke severity being the strongest correlate. Activities of daily living was associated with indoor autonomy, family role, and outdoor autonomy, but not associated with social life. Conclusions The perceived participation of our respondents is relatively optimistic. Physical health along with mental and social status can affect participation. Tailored strategies should be implemented early in the rehabilitation phase to promote stoke survivors' participation in all the domains. Implications for rehabilitation Although the overall perceived participation of young and middle-aged stroke patients was fair to good, attention should be paid to their family roles. The strategies should be mainly focused on reducing the stroke severity to improve patients' participation. Improving patients' depressive symptom and social support can also be helpful for improving their participation.

3.
Zhongguo Zhen Jiu ; 39(8): 809-13, 2019 Aug 12.
Artigo em Chinês | MEDLINE | ID: mdl-31397123

RESUMO

OBJECTIVE: To observe the related factors of left ventricular configuration in patients with mild to moderate hypertension, and to evaluate the influence of acupuncture on left ventricular configuration and cardiac function. METHODS: Huoxue Sanfeng acupuncture regime formulated by academician SHI Xue-min was applied to 200 patients with mild to moderate hypertension. The treatment was given once a day, 5 times a week for 3 months. Blood pressure and blood lipid levels were measured before treatment. Before treatment and 3 months after treatment, the echocardiography was used to measured end-diastolic left ventricular diameter (LVIDd), end-diastolic left ventricular posterior wall thickness (LVPWTd), and end-diastolic interventricular septum thickness (IVSTd), ejection fraction (EF), left ventricular mass index (LVMI), etc.; the relevant influencing factors of different left ventricular configurations were analyzed. RESULTS: The patients with mild to moderate hypertension had left ventricular dysplasia (left ventricular remodeling, concentric hypertrophy, eccentric hypertrophy) reached 60%, and compared with the normal configuration group and the left ventricular remodeling group, there were significant differences in nighttime mean pulse pressure, total cholesterol, BMI and waist circumference in the eccentric hypertrophy group (P<0.05). LVMI was associated with nighttime pulse pressure, waist circumference, total cholesterol and BMI (P<0.05). Left ventricular relative wall thickness was associated with total cholesterol, BMI and waist circumference (P<0.05). The diastolic function from normal configuration to left ventricular remodeling, concentric hypertrophy and eccentric hypertrophy gradually decreased, but there were no significant difference (P>0.05). The systolic function in the concentric hypertrophy group and the eccentric hypertrophy group was significantly lower than that in the normal configuration group and the left ventricular remodeling group (P<0.05). There was no significant difference in left ventricular systolic function and diastolic function before and after acupuncture (P>0.05). CONCLUSION: Sixty percents of patients with mild to moderate hypertension have abnormal left ventricular configuration and are associated with total cholesterol, BMI, waist circumference and nighttime mean pulse pressure. Studies have not found that acupuncture can significantly improve the left ventricular configuration and left cardiac function.

4.
Zhongguo Zhen Jiu ; 39(7): 703-7, 2019 Jul 12.
Artigo em Chinês | MEDLINE | ID: mdl-31286730

RESUMO

OBJECTIVE: To observe the characteristics of carotid intima-media thickness (IMT) and cerebral blood flow velocity in patients with mild-to-moderate hypertension, and to evaluate the effects of acupuncture on carotid IMT and blood flow velocity of middle cerebral artery and vertebral-basilar artery. METHODS: A total of 240 patients with mild-to-moderate hypertension who met the inclusion criteria were treated with Huoxue Sanfeng acupuncture method proposed by academician SHI Xue-min. The acupoints of Renying (ST 9), Quchi (LI 11), Hegu (LI 4), Zusanli (ST 36) and Taichong (LR 3) were selected. The treatment was given once a day, five times a week for 3 months. The carotid ultrasonography and transcranial color Doppler were performed before treatment and 3 months after treatment to evaluate the improvements of carotid IMT and brain blood flow velocity. RESULTS: Among 175 patients, 94.3% suffered from impaired carotid IMT. After acupuncture intervention, 7.7%-10.9% patients had improved IMT but 4.6%-6.3% had aggravated carotid IMT. There was no significant difference of carotid IMT before and after treatment (P>0.05). About 50% patients had abnormal intracranial blood flow velocity; after acupuncture intervention, 27.4%-33.3% patients who had the abnormal blood flow velocity had normal one, but 27.0%-52.5% patients who had normal blood flow velocity had abnormal one. After acupuncture intervention, the low-speed blood flow of MCA, VA and BA in female patients aged 41-60 years and the low-speed blood flow of MCA and VA in female patients aged 61-70 years were significantly improved (all P<0.05); the high-speed blood flow of MCA and VA in male patients aged 61-70 years and the high-speed blood flow of VA and BA in female patients aged 41-60 years were significantly decreased (all P<0.05). CONCLUSION: Nearly 95% of patients with mild-to-moderate hypertension had carotid IMT, and about 50% had abnormal blood flow velocity of intracranial artery. The present study failed to found significant effects of acupuncture on carotid IMT, but it shows acupuncture can generally improve the low blood flow velocity in women with mild-to-moderate hypertension.


Assuntos
Terapia por Acupuntura , Hipertensão , Adulto , Idoso , Velocidade do Fluxo Sanguíneo , Espessura Intima-Media Carotídea , Circulação Cerebrovascular , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
5.
Org Biomol Chem ; 17(29): 7055-7065, 2019 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-31304943

RESUMO

An efficient copper-mediated ortho-C(sp2)-H thiolation of aromatic amides directed by a novel directing group [4-chloro-2-(1H-pyrazol-1-yl)phenyl]amine has been developed without the need of other additives or oxidants, allowing for an increased usefulness. With the high compatibility of sterically demanding substrates, this reaction is scalable and can tolerate a wide scope of functional groups to provide alkyl and aryl thioethers in good to excellent yields (up to 93%). Furthermore, the protocol has been successfully implemented for the selenylation as well.

6.
Food Res Int ; 121: 463-470, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31108770

RESUMO

Umami is critical to the taste of shiitake mushroom. To isolate and identify umami peptides, fractions from hydrolyzed dried shiitake mushroom were separated by ultrafiltration, gel filtration chromatography (GFC), and reversed-phase high-performance liquid chromatography (RP-HPLC). Separations were combined with sensory evaluations (grading and taste dilution analysis) and analysis of electronic tongue, which were used to identify the most umami component in shiitake mushroom. Low-molecular-weight fractions (MW < 3 kDa) have the strongest flavor in the shiitake mushroom hydrolysate. In the 3 subfractions separated from low-molecular-weight fractions (MW < 3 kDa) by GFC, the second subfraction (F2) was selected for RP-HPLC analysis. The first peak (G1) in RP-HPLC was identified by LC-Q-TOF-MS, and 2 tripeptides and 3 dipeptides were identified. The amino acid sequence of these peptides were Gly-Cys-Gly, Glu-Pro-Glu, Cys-Met, Val-Phe, and Gly-Glu.

7.
Psychiatr Genet ; 29(4): 127-129, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30933047

RESUMO

Dysregulation of the immune system in mental disease, particularly complement component 4 (C4), which may be associated with schizophrenia, has been repeatedly observed. This study investigated the association between the level of serum component 4 and schizophrenia. Data were derived from a case-control association study of 40 unrelated adult patients with schizophrenia and 40 matched healthy controls. The component 4 level in serum was measured for comparative analysis by a component 4 enzyme-linked immunosorbent assay kit. Our findings suggest that the serum component 4 level is lower in patients with schizophrenia than in the controls, and the results apply to both males and females. Our results will lay an important foundation for establishing diagnostic methods and provide feasible and reliable evidence for the clinical treatment of schizophrenia.

8.
Ying Yong Sheng Tai Xue Bao ; 30(4): 1287-1294, 2019 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-30994290

RESUMO

Based on a two-year field experiment located at Shenyang Applied Ecological Experiment Station of Chinese Academy of Sciences, we examined the effects of stabilized N fertilizer combined with straw returning on rice yield and emission of N2O and CH4 in aquic brown soil. Six treatments were set up, i.e. control (CK), urea(U), urea+urease inhibitor+nitrification inhibitor (U+I), straw (S), straw+urea (S+U), straw+urea+ urease inhibitor+nitrification inhibitor (S+U+I). The results showed that urea application increased rice yield, cumulative N2O and CH4 emission, and global warming potential. The treatment of U+I significantly mitigated cumulative N2O emission. Returning rice straw to the field significantly increased cumulative N2O emission, cumulative CH4 emission, global warming potential, and greenhouse gas emission intensity. The S+U+I treatment had the highest rice yield and greenhouse gas emission intensity. U+I treatment had the the second highest rice yield and the lowest greenhouse gas emission intensity. Rice yield in the S treatment showed no significant difference with CK. Our results indicated that S+U+I and U+I are relatively better agricultural strategies compared with other treatments in paddy fields on aquic soil.


Assuntos
Agricultura/métodos , Fertilizantes , Gases de Efeito Estufa/análise , Metano/análise , Óxido Nitroso/análise , Oryza/crescimento & desenvolvimento , Solo
9.
Int J Biol Macromol ; 133: 391-411, 2019 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-30974145

RESUMO

Previously, we have identified the C3dg protein as an important player in the pathogenesis of atopic dermatitis (AD). In this study, we aimed to identify critical factors associated with C3dg in human keratinocytes based on high-throughput screening (HTS) approaches. We overexpressed C3dg in HaCaT human keratinocytes and conducted serial HTS studies, including RNA sequencing analysis integrated with antibody-chip arrays and implementation of bioinformatics algorithms (PPI mappings). Cumulatively, these approaches identified several novel C3dg-associated genes and proteins that are thought to be significantly involved in skin diseases including AD. These novel genes and proteins included LPA, PROZ, BLK, CLDN11, and FGF22, which are believed to play important roles in C3dg-associated skin functions in keratinocytes, as well as genes related to the two important pathways of systemic lupus erythematosus and Staphylococcus aureus infection. In particular, FGF22 is a unique gene that was detected and validated in all methods applied in this study. By integrating the datasets obtained from these HTS studies and utilizing the strengths of each method, we obtained new insights into the functional role of C3dg in keratinocytes. The approach used here contributes to clinical understanding of C3dg-associated applications and may also be applicable to treatment of AD.

10.
Environ Int ; 126: 717-726, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30878867

RESUMO

Long term mining activities can cause significant metal pollution in the environment, thereby showing potential risk to the paddy field. Elucidating the interfacial processes of trace metals from contaminated paddy soil to rice within the rhizosphere can provide important information on metal biogeochemistry and food safety. The current study aims to explore the spatial distribution and molecular speciation of Cu from rhizosphere to rice plant in a mining-impacted paddy soil, and reveal the possible uptake mechanisms. X-ray absorption near edge structure (XANES) analysis indicated that Cu was primarily associated with iron oxide and sulfide in soil with a minor proportion of organic complexed species. In the rice samples, Cu showed much higher concentrations in the roots than the shoots, as most Cu was sequestered in the root surface and epidermis (primarily in the form of C/N ligands bound Cu species), rather than root xylem, as identified by micro X-ray fluorescence (µ-XRF) imaging coupling with µ-XANES. By contrast, in the root xylem, thiol-S bound Cu(I) complex was observed, representing the reduced product of Cu(II) by thiol-S ligands in rice root. The absorbed Cu was probably transported from the root to the aerial part as C/N ligand bound Cu complex such as Cu-histidine like species, which was observed in the root xylem. The large retention capacity and reduction of Cu(II) in rice root alleviated Cu toxicity to rice, which was beneficial for food safety (e.g., lower concentration of Cu in rice grains). These findings showed for the first time that the uptake mechanisms by rice from field contaminated sites, which shed light on Cu detoxification process and potential remediation strategies.

11.
Medicine (Baltimore) ; 98(10): e14747, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30855469

RESUMO

The association between adiposity parameters and cognition is complex. The purpose of this study was to assess the relationship between adiposity parameters and cognition in middle-aged and elderly people in China.Data were obtained from a cross-sectional study. Cognitive function was evaluated in 5 domains, and adiposity parameters were measured. The association between adiposity parameters and cognition was analyzed using multiple linear and binary logistic regression analyses.After controlling for confounders, men with overweight and obesity had better scores in TICS-10 ([1] total, overweight vs normal: P = .006, ß = 0.04; obesity vs normal: P = .005, ß = 0.04. [2] stratification by age, with age ≥ 59 years, overweight vs normal: P = .006, ß = 0.05; obesity vs normal: P = .014, ß = 0.05. [3] stratification by educational levels, with less than elementary education, overweight vs normal: P = .011, ß = 0.05; obesity vs normal: P = .005, ß = 0.05), immediate word recall ([1] total, overweight vs normal: P = .015, ß = 0.04. [2] stratification by age, with age 45-58 years, overweight vs normal: P = .036, ß = 0.05. [3] stratification by educational levels, with less than elementary education, overweight vs normal: P = .044, ß = 0.04; above high school, overweight vs normal: P = .041, ß = 0.09), self-rated memory ([1] stratification by age, with age ≥ 59 years, overweight vs normal: P = .022, ß = 0.05. [2] stratification by educational levels, with less than elementary education, overweight vs normal: P = .023, ß = 0.04), and drawing a picture ([1] total, overweight vs normal: OR = 1.269, 95% CI = 1.05-1.53. [2] stratification by educational levels, with less than elementary education, overweight vs normal: OR = 1.312, 95% CI = 1.06-1.63); obesity vs normal: OR = 1.601, 95% CI = 1.11-2.31 than the normal weight; women with overweight and obesity had better measure scores in the TICS-10 ([1] total, overweight vs normal: P < .0001, ß = 0.06; obesity vs normal: P < .0001, ß = 0.05. [2] stratification by age, with age 45-58 years, obesity vs normal: P = .007, ß = 0.05; with age ≥ 59 years: overweight vs normal: P < .0001, ß = 0.07, obesity vs normal: P = .002, ß = 0.06. [3] stratification by educational levels, with illiterate, overweight vs normal: P = .001, ß = 0.08; obesity vs normal: P = .004, ß = 0.06; with less than elementary education, overweight vs normal: P < .0001, ß = 0.07; obesity vs normal: P = .010, ß = 0.05), immediate word recall ([1] total, overweight vs normal: P = .011, ß = 0.04; obesity vs normal: P = .002, ß = 0.04. [2] stratification by age, with age 45-58 years, obesity vs normal: P = .021, ß = 0.05; with age ≥ 59 years: overweight vs normal: P = .003, ß = 0.06. [3] stratification by educational levels, with illiterate, obesity vs normal: P = .028, ß = 0.05; with less than elementary education, obesity vs normal: P = .016, ß = 0.05), delay word recall ([1] total, overweight vs normal: P = .015, ß = 0.03; obesity vs normal: P = .031, ß = 0.03. [2] stratification by age, with age ≥ 59 years: overweight vs normal: P = .004, ß = 0.06. [3] stratification by educational levels, with less than elementary education, obesity vs normal: P = .043, ß = 0.04), self-rated memory ([1] total, obesity vs normal: P = .026, ß = 0.03. [2] stratification by age, with age ≥ 59 years, overweight vs normal: P = .044, ß = 0.04; obesity vs normal: P = .018, ß = 0.05), and drawing a picture ([1] total, overweight vs normal: OR = 1.226, 95% CI = 1.06-1.42. [2] stratification by age, with age 45-58 years: overweight vs normal: OR = 1.246, 95% CI = 1.02-1.53) than the normal weight. Regarding the association between WC and cognitive function, the obesity demonstrated better mental capacity ([1] total, men: P < .0001, ß = 0.06; women: P < .0001, ß = 0.05. [2] stratification by age, men with age 45-58 years: P < .0001, ß = 0.08; men with ≥ 59 years: P = .006, ß = 0.05. women with age 45-58 years: P = .001, ß = 0.06; women with ≥ 59 years: P = .012, ß = 0.04. [3] stratification by educational levels, men with illiterate: P = .045, ß = 0.09; men with less than elementary education: P < .0001, ß = 0.08; women with illiterate: P < .0001, ß = 0.09), ability to recall immediately ([1] total, men: P = .030, ß = 0.03; women: P = .001, ß = 0.05. [2] stratification by age, women with age 45-58 years: P = .028, ß = 0.04; women with ≥ 59 years: P = .007, ß = 0.05. [3] stratification by educational levels, men with less than elementary education: P = .007, ß = 0.05; women with illiterate: P = .027, ß = 0.05; women with less than elementary education: P = .002, ß = 0.06), delay word recall ([1] total, women: P = .044, ß = 0.03. [2] stratification by educational levels, men with less than elementary education: P = .023, ß = 0.04), self-rated memory (stratification by educational levels, women with less than elementary education: P = .030, ß = 0.04), and draw a picture ([1] total, men: OR = 1.399, 95% CI = 1.17-1.67; women: OR = 1.273, 95% CI = 1.12-1.45. [2] stratification by age, men with age 45-58 years: OR = 1.527, 95% CI = 1.15-2.03; men with age ≥ 59 years: OR = 1.284, 95% CI = 1.02-1.61; women with age 45-58 years: OR = 1.320, 95% CI = 1.10-1.58; women with age ≥ 59 years: OR = 1.223, 95% CI = 1.01-1.49. [3] stratification by educational levels, men with less than elementary education: OR = 1.528, 95% CI = 1.25-1.87; women with illiterate: OR = 1.404, 95% CI = 1.14-1.73) than the participants with normal weight after the multivariate adjustment.Our study demonstrated a significant relationship between adiposity parameters and cognition that supports the "jolly fat" hypothesis.


Assuntos
Adiposidade , Cognição/fisiologia , Escolaridade , Obesidade , Idoso , Índice de Massa Corporal , China/epidemiologia , Correlação de Dados , Feminino , Humanos , Masculino , Testes de Memória e Aprendizagem , Pessoa de Meia-Idade , Obesidade/diagnóstico , Obesidade/epidemiologia , Obesidade/psicologia , Medição de Risco , Fatores de Risco , Fatores Sexuais , Circunferência da Cintura
12.
J Pain Symptom Manage ; 57(4): 783-792, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30639731

RESUMO

CONTEXT: An unresolved issue in symptom cluster (SC) research is that the numbers and types of SCs vary based on the multiple dimensions of the experienced symptoms that are used for SC identification. OBJECTIVE: This study aimed to identify SCs using the ratings of occurrence, severity, and distress in newly diagnosed acute myeloid leukemia (AML) patients at three stages of their induction therapy (i.e., T1, T2, and T3). Then, we evaluated the consensus among the numbers and types of symptoms in each SC identified by multiple dimensions over time. METHOD: The Chinese version of the Memorial Symptom Assessment Scale was used to evaluate the occurrence, severity, and distress ratings of 32 symptoms in patients newly diagnosed with AML during their induction therapy. Exploratory factor analysis was used for SCs identification. RESULTS: Using the three dimensions in the AML patients (n = 126), four SCs were identified at T1 and T3 and three SCs were identified at T2. The number of symptoms in individual SCs varied over time, whereas the specific symptoms in SCs remained similar over time. The severity ratings fit the data better than did the ratings of occurrence and distress. CONCLUSION: These findings provided insights into the most common SCs in AML patients undergoing induction therapy by multidimensional evaluation and could lay the foundation for future targeted symptom interventions. Further studies are needed to explore the mechanisms of SCs in AML patients undergoing the chemotherapy.

13.
Medicine (Baltimore) ; 98(3): e13688, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30653088

RESUMO

OBJECTIVE: This post hoc analysis of an open-label, single-arm, multicenter study was designed to assess the efficacy, safety, and tolerability of paliperidone extended release (ER) in Chinese patients with non-acute schizophrenia, after switching from olanzapine. METHODS: Patients with schizophrenia who were dissatisfied with prior olanzapine treatment switched to flexible paliperidone ER (3-12 mg/day) based on clinical judgment. Change from baseline to week 12 in Positive and Negative Syndrome Scale (PANSS) total scores (primary endpoint), PANSS subscale scores, response rate, Clinical Global Impression-Severity (CGI-S) score, personal and social performance (PSP) scores, patient satisfaction with treatment score, change in sleep quality, level of daytime sleepiness and safety were evaluated. RESULTS: Out of 118 enrolled patients, 95 (81%) completed the study. Mean duration of study was 76.9 (23.85) days. The primary endpoint, mean (SD) PANSS total score changed significantly from baseline to endpoint (-19.6 [18.71], P <.0001). Secondary endpoints including PANSS subscale score, PSP, patient satisfaction and daytime drowsiness also significantly improved (P <.001). Most commonly reported (≥1%) treatment-emergent adverse events were akathisia (n = 14 [12%]) and insomnia (n = 9 [8%]). CONCLUSIONS: Switching to flexible-dosed paliperidone ER in patients dissatisfied with prior olanzapine treatment achieved good efficacy and tolerability consistently over 12 weeks.


Assuntos
Antipsicóticos/uso terapêutico , Palmitato de Paliperidona/uso terapêutico , Satisfação do Paciente/estatística & dados numéricos , Esquizofrenia/tratamento farmacológico , Adulto , Acatisia Induzida por Medicamentos/epidemiologia , Antipsicóticos/administração & dosagem , Antipsicóticos/efeitos adversos , China/epidemiologia , Substituição de Medicamentos/métodos , Feminino , Humanos , Masculino , Olanzapina/efeitos adversos , Palmitato de Paliperidona/administração & dosagem , Palmitato de Paliperidona/efeitos adversos , Prevalência , Estudos Prospectivos , Esquizofrenia/epidemiologia , Distúrbios do Início e da Manutenção do Sono/induzido quimicamente , Resultado do Tratamento
14.
Int Clin Psychopharmacol ; 34(1): 37-44, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30308557

RESUMO

A new self-rating functional scale (SRFS) was developed to assess the functionality of patients with schizophrenia, referred to the structure of Personal and Social Performance Scale (PSP). The main aim of this study was to evaluate the reliability and validity of the SRFS. A total of 210 patients with schizophrenia were recruited from outpatient clinics in six sites in China. Demographic information, SRFS, PSP, World Health Organization Disability Assessment Schedule II, and Positive and Negative Syndrome Scale were assessed. Spearman's correlation coefficient and path analysis were used to assess the reliability and validity of the SRFS. Cronbach's α coefficient was used to assess the internal consistency reliability. Cronbach's α was 0.83, and ranged from 0.80 to 0.82 stably, indicating that the scale was reliable in internal consistency. Spearman's correlation coefficient between split two parts was 0.68 (P<0.01), suggesting a moderate to strong split-half reliability. The standardized regression coefficients ranged from 0.48 to 0.79, indicating moderate construct validity. Spearman's correlation coefficients between SRFS and PSP, World Health Organization Disability Assessment Schedule II, and Positive and Negative Syndrome Scale are 0.59, 0.65, and 0.47 (all P<0.01), respectively, indicating moderate criteria validities. The SRFS is a reliable and valid instrument for assessing personal and social functionality in patients with schizophrenia.

15.
Zhen Ci Yan Jiu ; 43(12): 754-8, 2018 Dec 25.
Artigo em Chinês | MEDLINE | ID: mdl-30585451

RESUMO

Prehypertension is an independent risk factor for end stage of heart, brain and renal diseases. The immune inflammatory imbalance promotes the occurrence of damage of target organs in the pre-hypertension stage. This article focuses on the relationship between the immune-inflammation and prehypertension and its target organ damage. It was found that acupuncture treatment can lower blood pressure, postpone the development of prehypertension, improve vascular endothelia function and immune function, down-regulate the levels of serum proinflammatory cytokines, and reduce inflammatory reactions of the heart and kidney, possible by way of regulating cellular signal pathways as TLR 4/NF-κB, p 38/MAPK, CaM-eNOS-NO, TGF-ß 1/Smads, etc. and playing a protective effect on the target organs. However, its detailed mechanisms remain largely unknown up to now.


Assuntos
Terapia por Acupuntura , Pré-Hipertensão , Pressão Sanguínea , Citocinas , Humanos , Inflamação , Pré-Hipertensão/terapia
16.
Environ Sci Pollut Res Int ; 25(36): 36223-36238, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30362041

RESUMO

In November 2013, the total concentration of selected heavy metals in 43 urban dust samples, collected from two small-sized cities of industrial E'zhou and agricultural Huanggang, located in the southeastern Hubei province, central China, was detected quantitatively by flame atomic absorption spectrometric (FAAS) for ultimate purpose of pollution monitoring and risk evaluation. Results indicated that the mean concentrations exceeding their respective background values were observed for all the investigated metals, with the exception of Co (13.08mg kg-1) and Fe (38635.02mg kg-1) in Huanggang road dusts, whose average concentrations were close to the background levels. In comparison with the reference data reported from the selected cities worldwide, the urban road dusts were seriously polluted by heavy metals to diverse degrees. The contour distribution maps implied that obviously higher values zones were found between two different types of urban areas, located to both sides of the coastline of Yangtze River. Multivariate statistical analysis revealed that the enriched heavy metals had emanated from the combined effects of both natural sources and anthropogenic sources. Three pollution indices indicated that the riskiest element mainly comprising Cr, Ni, Cu, and Pb appeared to be the major contributors to the urban environmental pollution. Avoiding continuous damage requires, the riskiest metallic contaminants should be paid preferential attention to.

17.
J Sci Food Agric ; 2018 Oct 18.
Artigo em Inglês | MEDLINE | ID: mdl-30338537

RESUMO

BACKGROUND: As a potential health hazard, 5-hydroxymethylfurfural (HMF) has been detected in thermally processed foods high in sugar and amino acids. In order to analyze HMF quantitatively and investigate the kinetics of its formation, high-performance liquid chromatography was employed to determine the content of HMF in six sugar-amino acid thermal reaction models. RESULTS: In thermal reaction models, formation of HMF was significantly affected by sugar and amino acid composition, pH value and heating conditions. HMF formation increased with increasing sugar and amino acid (cysteine excepted) content, temperature and reaction time. A maximum amount of HMF of 1.50 g kg-1 was detected in the sucrose-glutamic acid model at 110 °C and 6 h. Low pH value and added acidic amino acids promoted the formation of HMF, especially in the sucrose-containing system. CONCLUSION: HMF formation followed first-order kinetics in four models, including the model of glucose-cysteine, glucose-glutamic acid, glucose-leucine and sucrose-leucine. In contrast, HMF formation followed zero-order kinetics in the model of sucrose-glutamic acid. The quantity of HMF increased as the quantity of sugar and amino acid increased (cysteine excepted) in six tested models. © 2018 Society of Chemical Industry.

18.
Int J Mol Sci ; 19(10)2018 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-30274198

RESUMO

Bolting is a key process in the growth and development of lettuce (Lactuca sativa L.). A high temperature can induce early bolting, which decreases both the quality and production of lettuce. However, knowledge of underlying lettuce bolting is still lacking. To better understand the molecular basis of bolting, a comparative proteomics analysis was conducted on lettuce stems, during the bolting period induced by a high temperature (33 °C) and a control temperature (20 °C) using iTRAQ-based proteomics, phenotypic measures, and biological verifications using qRT-PCR and Western blot. The high temperature induced lettuce bolting, while the control temperature did not. Of the 5454 identified proteins, 619 proteins presented differential abundance induced by high-temperature relative to the control group, of which 345 had an increased abundance and 274 had a decreased abundance. Proteins with an abundance level change were mainly enriched in pathways associated with photosynthesis and tryptophan metabolism involved in auxin (IAA) biosynthesis. Moreover, among the proteins with differential abundance, proteins associated with photosynthesis and tryptophan metabolism were increased. These findings indicate that a high temperature enhances the function of photosynthesis and IAA biosynthesis to promote the process of bolting, which is in line with the physiology and transcription level of IAA metabolism. Our data provide a first comprehensive dataset for gaining novel understanding of the molecular basis underlying lettuce bolting induced by high temperature. It is potentially important for further functional analysis and genetic manipulation for molecular breeding to breed new cultivars of lettuce to restrain early bolting, which is vital for improving vegetable quality.

19.
Onco Targets Ther ; 11: 6767-6775, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30349309

RESUMO

Purpose: Oxidative stress was significantly associated with the development of malignancies. The purpose of this study was to evaluate the significance of serum total oxidant/antioxidant status in operable advanced gastric cancer patients. Materials and methods: A total of 284 patients who underwent curative resection for primary stage III gastric cancer were enrolled. Total oxidant status, total antioxidant status, and oxidative stress index (OSI) were evaluated within 24 hours before surgery, and compared with 120 healthy donors. The correlation between the OSI and survival outcome was analyzed by the Kaplan-Meier method with log-rank test and Cox's regression methods, respectively. Results: Mean OSI of gastric cancer patients was higher than healthy controls (1.41±0.96 vs 0.78±0.42, P<0.001). All patients were stratified into two groups using the optimal cutoff value (1.42) of OSI using a sensitivity of 94.1% and a specificity of 64.0% as optimal conditions from receiver operating curve analysis. Patients with an OSI ≥1.42 had poorer mean overall survival (45.6 vs 29.8 months, P=0.022) and mean recurrence-free survival (43.3 vs 28.1 months, P=0.011) than patients with an OSI <1.42 in univariate analysis, and OSI was also confirmed as an independent predictor for survival for gastric cancer in multivariate analysis (hazard ratio, 0.541; 95% CI: 0.127-1.102; P=0.01). Conclusion: Preoperative OSI can be considered as an independent prognostic factor for operable and advanced gastric cancer.

20.
Medicine (Baltimore) ; 97(38): e12352, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30235693

RESUMO

The depressive symptoms have been associated with increased disabilities, and the depressive symptoms-related elevation of high C-reactive protein (CRP) has been proposed as a possible mechanism. We examined the relations between CRP and depressive symptoms among the middle-aged and elderly in China.A longitudinal sample of the middle-aged and elderly (4404 men and 5055 women) who were interviewed in the 2011 China Health and Retirement Longitudinal Study was used. A multivariate logistic regression analysis was used to examine the effects of sociodemographic characteristics, lifestyle, activity status, physical exercise, systolic blood pressure, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, body mass index (BMI), and CRP levels on depressive symptoms.The mean age in the study was 60.26 years [standard deviation (SD) ±â€Š9.25; 46.56% men]. The mean CPR level was 2.79 mg/L (range, 0.01-178.10; SD ±â€Š7.80). Depression scores ranged from 0 to 30 with a mean 8.65 (SD ±â€Š6.33). The prevalence of depressive symptoms was 38.49% in the total population, 31.04% in men and 44.99% in men. Compared with baseline CRP levels (≤1.00 mg/L), the depressive symptoms are only weakly correlated with CRP levels among women [CRP 1.01-3.00 mg/L: odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.73-0.98; CRP 3.01-10.00 mg/L: OR = 1.25, 95% CI = 1.03-1.51; CRP >10 mg/L: OR = 1.41, 95% CI = 1.06-1.88]. After adjusting for age, education, marital status, hukou, residence, cigarette smoking, alcohol drinking, eating meals, activity status, major accidental injury, diseases, health status, physical exercise, systolic blood pressure, LDL, HDL, triglycerides, and BMI, depressive symptoms were not associated with subsequent high CPR levels among the middle-aged and elderly (CRP 1.01-3.00 mg/L: OR = 0.93, 95% CI = 0.83-1.03; CRP 3.01-10.00 mg/L: OR = 0.95, 95% CI = 0.82-1.10; CRP >10 mg/l: OR = 1.11, 95% CI = 0.88-1.39).Our data do not support an association between CRP and depressive symptoms in both middle-aged and elderly men and women among china.


Assuntos
Proteína C-Reativa/análise , Depressão/sangue , Idoso , China , Feminino , Nível de Saúde , Humanos , Modelos Logísticos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Razão de Chances , Aposentadoria/psicologia , Fatores de Risco
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