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1.
Acta Neurochir Suppl ; 127: 105-119, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31407071

RESUMO

The protein kinase RNA-like endoplasmic reticulum kinase (PERK) pathway, which is a branch of the unfolded protein response, participates in a range of pathophysiological processes of neurological diseases. However, few studies have investigated the role of the PERK in intracerebral hemorrhage (ICH). The present study evaluated the role of the PERK pathway during the early phase of ICH-induced secondary brain injury (SBI) and its potential mechanisms. An autologous whole blood ICH model was established in rats, and cultured primary cortical neurons were treated with oxyhemoglobin to mimic ICH in vitro. We found that levels of phosphorylated alpha subunit of eukaryotic translation initiation factor 2 (p-eIF2α) and activating transcription factor 4 (ATF4) increased significantly and peaked at 12 h during the early phase of the ICH. To further elucidate the role of the PERK pathway, we assessed the effects of the PERK inhibitor, GSK2606414, and the eIF2α dephosphorylation antagonist, salubrinal, at 12 h after ICH both in vivo and in vitro. Inhibition of PERK with GSK2606414 suppressed the protein levels of p-eIF2α and ATF4, resulting in increase of transcriptional activator CCAAT/enhancer-binding protein homologous protein (CHOP) and caspase-12, which promoted apoptosis and reduced neuronal survival. Treatment with salubrinal yielded opposite results, which suggested that activation of the PERK pathway could promote neuronal survival and reduce apoptosis. In conclusion, the present study has demonstrated the neuroprotective effects of the PERK pathway during the early phase of ICH-induced SBI. These findings highlight the potential value of PERK pathway as a therapeutic target for ICH.

2.
IEEE Trans Image Process ; 29: 237-249, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31369377

RESUMO

Unsupervised video object segmentation aims to automatically segment moving objects over an unconstrained video without any user annotation. So far, only few unsupervised online methods have been reported in the literature, and their performance is still far from satisfactory because the complementary information from future frames cannot be processed under online setting. To solve this challenging problem, in this paper, we propose a novel unsupervised online video object segmentation (UOVOS) framework by construing the motion property to mean moving in concurrence with a generic object for segmented regions. By incorporating the salient motion detection and the object proposal, a pixel-wise fusion strategy is developed to effectively remove detection noises, such as dynamic background and stationary objects. Furthermore, by leveraging the obtained segmentation from immediately preceding frames, a forward propagation algorithm is employed to deal with unreliable motion detection and object proposals. Experimental results on several benchmark datasets demonstrate the efficacy of the proposed method. Compared to state-of-the-art unsupervised online segmentation algorithms, the proposed method achieves an absolute gain of 6.2%. Moreover, our method achieves better performance than the best unsupervised offline algorithm on the DAVIS-2016 benchmark dataset. Our code is available on the project website: https://www.github.com/visiontao/uovos.

3.
Sci Rep ; 9(1): 14484, 2019 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-31597925

RESUMO

Contact resistance and current crowding are important to nanoscale electrical contacts. In this paper, we present a self-consistent model to characterize partially overlapped parallel contacts with varying specific contact resistivity along the contact length. For parallel tunneling contacts formed between contacting members separated by a thin insulating gap, we examine the local voltage-dependent variation of potential barrier height and tunneling current along the contact length, by solving the lumped circuit transmission line model (TLM) equations coupled with the tunneling current self consistently. The current and voltage distribution along the parallel tunneling contacts and their overall contact resistance are analyzed in detail, for various input voltage, electrical contact dimension, and material properties (i.e. work function, sheet resistance of the contact members, and permittivity of the insulating layer). It is found the existing one-dimensional (1D) tunneling junction models become less reliable when the tunneling layer thickness becomes smaller or the applied voltage becomes larger. In these regimes, the proposed self-consistent model may provide a more accurate evaluation of the parallel tunneling contacts. For the special case of constant ohmic specific contact resistivity along the contact length, our theory has been spot-checked with finite element method (FEM) based numerical simulations. This work provides insights on the design, and potential engineering, of nanoscale electrical contacts with controlled current distribution and contact resistance via engineered spatially varying contact layer properties and geometry.

4.
Cardiovasc Res ; 2019 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-31593224

RESUMO

AIMS: Blood flow patterns play an important role in the localization of atherosclerosis in the sense that low-flow state is pro-atherogenic, and helical flow is protective against atherosclerosis. Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates cholesterol metabolism via LDL receptor degradation and is highly expressed in the atherosclerotic tissues. This study was designed to investigate the role of different blood flow patterns in the regulation of PCSK9 expression. METHODS AND RESULTS: We designed an experimental model guider to generate stable helical flow. Our data showed that compared with normal flow, low flow state induces while helical flow inhibits PCSK9 expression in the rabbit thoracic aorta in an inflammatory state. Our data also identified that TLR4-MyD88-NF-κB signaling plays an important role in PCSK9 expression. On the other hand, TRIF pathway had almost no effect. Further studies showed that the signals downstream of NF-κB, such as proinflammatory cytokines (IL-1ß, IL-18, MCP-1, IL-6, TNF-α, IL-12, IFNγ and GM-CSF) directly influence PCSK9 expression. Interestingly, high fat diet further enhanced PCSK9 expression in an inflammatory milieu. CONCLUSIONS: These observations suggest a link between abnormal flow patterns and PCSK9 expression in inflammatory states, which may qualify helical flow and proinflammatory cytokines as potential targets to treat PCSK9 related cardiovascular diseases. TRANSLATIONAL PERSPECTIVE: PCSK9 regulates LDL receptor degradation and plays key roles in hypercholesterolemia and related cardiovascular diseases. In this study, we show that helical flow which is associated with atherosclerosis induces more PCSK9 than linear flow. Further proinflammatory cytokines directly determine PCSK9 levels. As upstream pathway, TLR4-MyD88-NF-κB signaling plays an important role in the regulation of PCSK9 expression. TRIF has almost no effect in this signaling. Thus, inhibition of TLR4-MyD88-NF-κB signaling may be a novel strategy to attenuate PCSK9 release associated with helical flow.

5.
Dis Markers ; 2019: 3863458, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31565098

RESUMO

Objective: Circular RNAs (circRNAs) have been reported to be widely involved in pathological processes of various cancers. However, little is known about their diagnostic values in early gastric cancer (EGC). This study is aimed at exploring whether circulating circRNAs in plasma could act as biomarkers for EGC diagnosis. Materials and Methods: Mass spectrometry (MS) was performed to identify the proteins that at significantly aberrantly levels in gastric cancer (GC) tissues. The target circRNA was identified by bioinformatics analysis. A receiver operating characteristic (ROC) curve was generated to evaluate the diagnostic utility. Results: MS revealed that the ribosomal protein L6 (RPL6) expression was significantly downregulated only in EGC tissues vs. nontumorous tissues; this was validated by western blotting (n = 30, p = 0.0094). Bioinformatics analysis predicted that there is a hsa_circ_0006848/hsa_miR-329-5p/RPL6 axis in GC progression. The hsa_circ_0006848 expression was significantly downregulated in EGC tissues (vs. nontumorous tissues, n = 30, p = 0.0073) and plasma samples from EGC patients (vs. paired healthy volunteers, n = 30, p = 0.0089). In addition, the hsa_circ_0006848 plasma level in postoperative patients was significantly higher than that of preoperative patients (n = 30, p = 0.047). Furthermore, the decreased hsa_circ_0006848 expression in plasma was negatively correlated with poor differentiation (p = 0.037) and tumor size (p = 0.046). The area under the ROC curve (AUC) of hsa_circ_0006848 in plasma was 0.733, suggesting a good diagnostic value. The plasma hsa_circ_0006848 level combined with the carcinoembryonic antigen (CEA), carbohydrate-associated antigen 19-9 (CA19-9), and carbohydrate-associated antigen 72-4 (CA72-4) level increased the AUC to 0.825. Conclusion: Our results indicated that plasma hsa_circ_0006848 may be a novel noninvasive biomarker in EGC diagnosis.

6.
Small ; : e1904116, 2019 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-31588680

RESUMO

2D layers of metal dichalcogenides are of considerable interest for high-performance electronic devices for their unique electronic properties and atomically thin geometry. 2D SnS2 nanosheets with a bandgap of ≈2.6 eV have been attracting intensive attention as one potential candidate for modern electrocatalysis, electronic, and/or optoelectronic fields. However, the controllable growth of large-size and high-quality SnS2 atomic layers still remains a challenge. Herein, a salt-assisted chemical vapor deposition method is provided to synthesize atomic-layer SnS2 with a large crystal size up to 410 µm and good uniformity. Particularly, the as-fabricated SnS2 nanosheet-based field-effect transistors (FETs) show high mobility (2.58 cm2 V-1 s-1 ) and high on/off ratio (≈108 ), which is superior to other reported SnS2 -based FETs. Additionally, the effects of temperature on the electrical properties are systematically investigated. It is shown that the scattering mechanism transforms from charged impurities scattering to electron-phonon scattering with the temperature. Moreover, SnS2 can serve as an ideal material for energy storage and catalyst support. The high performance together with controllable growth of SnS2 endow it with great potential for future applications in electrocatalysis, electronics, and optoelectronics.

7.
Inorg Chem ; 2019 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-31577144

RESUMO

A series of isomorphic lanthanide metal-organic frameworks (Ln-MOFs), {[Ln(L)(H2O)2]·5H2O}n (1-Ln, where Ln = Eu, Tb, Gd, and EuxTb1-x), have been synthesized by a rigid 1,3-bis(3,5-dicarboxyphenyl)imidazolium chloride (H4L+Cl-) ligand and Ln3+ ions via a solvothermal method. Single-crystal X-ray diffraction indicated that 1-Ln exhibited similar three-dimensional porous frameworks with one-dimensional channels decorated by the uncoordinated carboxylate oxygen atoms. The luminescent sensing studies indicated that 1-Eu is an outstanding reusable luminescent probe suitable for the simultaneous detection of Cr2O72-, CrO42-, and MnO4- ions in an aqueous solution. Remarkably, the different proportions of Eu3+ and Tb3+ can be combined into the same Ln-MOF to yield a new series of differently doped 1-EuxTb1-x MOFs. At the same excitation wavelength, they generated dual-emission peaks of Eu3+ and Tb3+ to show a gradual change in luminous color between yellow-green, yellow, orange, orange-red, and red. On the basis of the excellent optical properties of 1-Ln complexes, they can be employed as promising luminescent probe and multicolor tunable photoluminescence materials.

8.
Nat Commun ; 10(1): 4472, 2019 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-31578330

RESUMO

Moiré superlattices (MSLs) are modulated structures produced from homogeneous or heterogeneous 2D layers stacked with a twist angle and/or lattice mismatch. Expanding the range of available materials, methods for fabricating MSL, and realization of unique emergent properties are key challenges. Here we report a facile bottom-up synthesis of homogeneous MSL based on a wide-gap 2D semiconductor, BiOCl, using a one-pot solvothermal approach with robust reproducibility. Unlike previous MSLs usually prepared by directly stacking two monolayers, our BiOCl MSLs are realized in a scalable, direct way through chemical growth of spiral-type nanosheets driven by screw-dislocations. We find emergent properties including large band gap reduction (∼0.6 eV), two-fold increase in carrier lifetime, and strongly enhanced photocatalytic activity. First-principles calculations reveal that such unusual properties can be ascribed to the locally enhanced inter-layer coupling associated with the Moiré potential modulation. Our results demonstrate the promise of MSL materials for chemical and physical functions.

9.
Aging (Albany NY) ; 112019 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-31581131

RESUMO

Recently, an increasing number of studies have reported that dysregulation of long noncoding RNAs (lncRNAs) plays an important role in cancer initiation and progression, including in epithelial ovarian carcinoma (EOC). However, little is known about the detailed biological functions of the lncRNA small nucleolar RNA host gene 22 (SNHG22) during the progression of EOC. Here, we found that SNHG22 was significantly increased in EOC tissues and was significantly associated with a low level of differentiation. Forced SNHG22 expression promoted chemotherapy resistance in EOC cells. Knockdown of SNHG22 expression increased the sensitivity of EOC cells to cisplatin and paclitaxel. Importantly, we found that SNHG22 could directly interact with miR-2467 and lead to the release of miR-2467-targeted Gal-1 mRNA. Moreover, SNHG22 overexpression induced EOC cell resistance to chemotherapy agents via PI3K/AKT and ERK cascade activation. In summary, our findings demonstrate that SNHG22 plays a critical role in the chemotherapy resistance of EOC by mediating the miR-2467/Gal-1 regulatory axis.

10.
Aging (Albany NY) ; 112019 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-31581133

RESUMO

Two-pore-domain (KCNK, K2P) K+ channels are transmembrane protein complexes that control the flow of ions across biofilms, which underlie many essential cellular functions. Because KCNK family members are known to contribute to tumorigenesis in various types of cancer, we hypothesized that they might be differentially expressed in hepatocellular carcinoma (HCC) cells as compared to healthy tissue and serve as diagnostic or prognostic biomarkers. We tested this hypothesis through bioinformatic analyses of publicly available data for the expression of various KCNK subunits in HCC. We observed reduced expression of KCNK2, KCNK15, and KCNK17 in liver cancer, as well as overexpression of KCNK9, all of which correlated with a better prognosis for HCC patients per survival analyses. Moreover, ROC curves indicated that KCNK2, KCNK9, KCNK15, and KCNK17 levels could be used as a diagnostic biomarker for HCC. Finally, our western blot and qRT-PCR results were consistent with those obtained from bioinformatic analyses. Taken together, these results suggest that KCNK2, KCNK9, KCNK15, and KCNK17 could serve as potential diagnostic and prognostic biomarkers of HCC.

11.
Biomed Pharmacother ; : 109437, 2019 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-31590992

RESUMO

Immune checkpoint inhibitors (ICPIs) and chimeric antigen receptor (CAR) T-cell therapy are two main promising methods of immunotherapy, which have become increasingly important in cancer treatment. After the wider application of these medicine in clinic, a range of immune related adverse events (irAEs) covering almost any system arouse the concern for being randomness and unpredictability. Even if most adverse events are mild and controllable after thoughtful management, the occurrence of life-threatening toxicities should not be ignored because of the insidious and atypical symptoms, which makes the early diagnosis even more challenging. In this review, a brief introduction of immunotherapy and mechanisms underlying irAEs is involved. We mainly focus on the early diagnostic method and recommended management of toxicities of different systems separately, and consequently maximized effectiveness of immunotherapy can be achieved.

12.
Nat Med ; 2019 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-31591594

RESUMO

The ability to expand hematopoietic stem and progenitor cells (HSPCs) ex vivo is critical to fully realize the potential of HSPC-based therapies. In particular, the application of clinically effective therapies, such as cord blood transplantation, has been impeded because of limited HSPC availability. Here, using 3D culture of human HSPCs in a degradable zwitterionic hydrogel, we achieved substantial expansion of phenotypically primitive CD34+ cord blood and bone-marrow-derived HSPCs. This culture system led to a 73-fold increase in long-term hematopoietic stem cell (LT-HSC) frequency, as demonstrated by limiting dilution assays, and the expanded HSPCs were capable of hematopoietic reconstitution for at least 24 weeks in immunocompromised mice. Both the zwitterionic characteristics of the hydrogel and the 3D format were important for HSPC self-renewal. Mechanistically, the impact of 3D zwitterionic hydrogel culture on mitigating HSPC differentiation and promoting self-renewal might result from an inhibition of excessive reactive oxygen species (ROS) production via suppression of O2-related metabolism. HSPC expansion using zwitterionic hydrogels has the potential to facilitate the clinical application of hematopoietic-stem-cell therapies.

13.
Environ Microbiol ; 2019 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-31600864

RESUMO

Myxococcus xanthus kills susceptible bacteria using myxovirescin A (TA) during predation. However, whether prey cells in nature can escape M. xanthus by developing resistance to TA is unknown. We observed that many field-isolated Bacillus licheniformis strains could survive encounters with M. xanthus, which was correlated to their TA resistance. A TA glycoside was identified in the broth of predation-resistant B. licheniformis J32 cocultured with M. xanthus, and a glycosyltransferase gene (yjiC) was up-regulated in J32 after the addition of TA. Hetero-expressed YjiC modified TA to a TA glucoside (TA-Gluc) by conjugating a glucose moiety to the C-21 hydroxyl group, and the resulting compound was identical to the TA glycoside present in the coculture broth. TA-Gluc exhibited diminished bactericidal activity due to its weaker binding with LspA, as suggested by in silico docking data. Heterologous expression of the yjiC gene conferred both TA and M. xanthus-predation resistance to the host E. coli cells. Furthermore, under predatory pressure, B. licheniformis Y071 rapidly developed predation-resistance by acquiring TA-resistance through the overexpression of yjiC and lspA genes. These results suggest that M. xanthus predation resistance in B. licheniformis is due to the TA deactivation by glucosylation, which is induced in a predator-mediated manner. This article is protected by copyright. All rights reserved.

14.
Environ Sci Technol ; 2019 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-31603317

RESUMO

Iron electrocoagulation (Fe EC) is normally considered as a separation process. Here we found that Fe(II)‒O2 interactions in Fe EC systems could produce reactive oxidants, mainly hydroxyl radicals (•OH), for refractory organic contaminants transformation. Production of reactive oxidants, probed by benzoate conversion to p-hydroxybenzoic acid (p-HBA), depended on dissolved oxygen (DO) concentration and Fe(II) speciation. Measurable levels of DO were required for significant p-HBA production. Fe precipitates evolved from lepidocrocite to magnetite when DO decreased to below the detection limit. Both experiments and kinetic modeling suggest that the main Fe(II) species contributing to reactive oxidants (mainly •OH) production changed from aqueous Fe(II) initially to lepidocrocite-sorbed Fe(II) with progressive precipitates formation. When DO was not measurable at high currents (≥ 50 mA or 100 mA/L), reactive oxidants production was ineffective because of pH rise and Fe(II) preservation in magnetite, but it could be enhanced drastically by aeration. The reactive oxidants produced at 30 mA (or 60 mA/L) could degrade about 47% of 10 µM aniline and 34% of sulfanilamide within 6 h of Fe EC treatment. Our findings highlight the importance of reactive oxidants for refractory organic contaminants oxidation in Fe EC systems.

15.
J Agric Food Chem ; 2019 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-31593461

RESUMO

Global Natural Product Social (GNPS) feature based networking was applied to follow the phytochemicals including 9 flavonoid glycosides, 6 catechins, and 3 flavonols in Huangjinya green tea. Further, a new 8-O-4'-type neolignan glycoside, camellignanoside A (1), together with 15 known compounds (2-16), were isolated through a variety of column chromatography, and the structure was elucidated extensively by UPLC-Q-TOF-MS2, 1H and 13C NMR, HSQC, HMBC, 1H-1H CCOY, ROESY, and NOESY, and circular dichroism (CD) spectroscopies. Compounds 1 and 2 showed acetylcolinesterase (AChE) inhibition activity with IC50 = 0.75 and 0.18 µM, respectively.

16.
Cell Cycle ; : 1-14, 2019 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-31594448

RESUMO

Spermatogenesis is an important physiological process associated with male infertility. As a kind of post-transcriptional regulation, RNA editings (REs) change the genetic information at the mRNA level. But whether there are REs and what's the role of REs during the process are still unclear. In this study, we integrated published RNA-Seq datasets and established a landscape of RNA REs during the development of mouse spermatogenesis. Totally, 7530 editing sites occurred in 2012 genes among all types of male germ cells were found, these sites enrich on some regions of chromosomes, including chromosome 17 and both ends of chromosome Y. We also found about half of the REs in CDSs can cause amino acids changes. Some non-synonymous REs which exist in specific genes may play important roles in spermatogenesis. Finally, we verified a non-synonymous A-to-I RNA editing site in Cog3 and a stoploss editing in Tssk6 during spermatogenesis. In short, we systematically analyzed the dynamic landscape of RNA editing at different stages of spermatogenesis.

17.
Medicine (Baltimore) ; 98(39): e17362, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31574882

RESUMO

RATIONALE: Klebsiella pneumoniae infection can induce multiple invasive abscesses, and the invasive infection is severe and life-threatening. PATIENT CONCERNS: A 69-year-old previously healthy Chinese male presented with fever, chill, backache, and ocular pain. DIAGNOSIS: The blood culture results indicated Klebsiella pneumoniae of the K1 serotype. Multiple invasive abscesses in liver, lung, eye, soft tissue, and central nervous system were identified by imaging examination. Subsequently, the patient experienced right ocular pain accompanied by visual disturbance. Tyndall sign was strongly positive, and lens opacity was observed by the ophthalmologist. INTERVENTIONS: Full-dose and long-term treatment with meropenem was performed. Intraventricular injection of glass and anterior chamber puncture with antibiotics were performed twice. The patient also underwent an evacuation of the brain abscess. OUTCOMES: The patient's headache and lumbar backache were relieved, his ophthalmodynia disappeared, and his vision recovered after nearly 3 months of treatment. LESSONS: Imaging examination is very important for severe Klebsiella pneumoniae infection. The choice of antibiotics is complex, and the antimicrobial regimen should be adjusted according to the assessment of illness and the therapeutic effect. Surgical intervention must be considered for patients with multiple invasive abscesses.


Assuntos
Abscesso/microbiologia , Antibacterianos/uso terapêutico , Infecções por Klebsiella/microbiologia , Klebsiella pneumoniae , Meropeném/uso terapêutico , Idoso , Humanos , Masculino
18.
J Phys Act Health ; : 1-6, 2019 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-31593924

RESUMO

BACKGROUND: The objective was to examine changes of children's time spent in sedentary, light physical activity, moderate to vigorous physical activity (MVPA), and estimated energy expenditure (EE) rates during weekdays and weekends across 3 years. METHODS: An initial sample of 261 children's (mean age = 7.81 y) 5-day physical activity and EE were assessed annually via accelerometry across 3 years using repeated-measures multivariate analysis of variance. The outcome variables were time spent in sedentary, light physical activity, MVPA, and kilocalories per day for weekdays and weekends. RESULTS: A significant decrease in MVPA and EE occurred during weekdays across the 3 years (P = .01). Only the second-year data demonstrated an increase (+2.49 min) in weekend MVPA (P = .04). Children's sedentary time during weekdays increased significantly in years 1 and 2 (P = .01), yet significantly decreased in the third year (-44.31 min). Children's sedentary time during weekends significantly decreased in the first year (-27.31 min), but increased in the following 2 years (P = .01). Children's light physical activity demonstrated a statistically significant increase in year 2 (+3.75 min) during weekdays (P = .05). CONCLUSIONS: Children's MVPA and EE generally declined during weekdays but were maintained during weekends across a 3-year time span. Children may benefit most from weekday intervention strategies.

20.
Clin Otolaryngol ; 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31573757

RESUMO

BACKGROUND: Pretreatment serum albumin (ALB) is a novel index that was identified in recent years and is considered to be closely related to the prognosis of nasopharyngeal carcinoma (NPC). However, the association between ALB and NPC remains controversial. OBJECTIVE OF REVIEW: To assess the prognostic significance of pretreatment serum ALB in patients with NPC. TYPE OF REVIEW: A systematic review and meta-analysis. SEARCH STRATEGY: We searched PubMed, the Cochrane Library, and the Web of Science for studies published up to August 2018. The keywords used were related to albumin, nasopharyngeal carcinoma and prognosis. EVALUATION METHOD: We extracted the following data from all included studies: author, publication year, country, cancer center, time points of randomization, sample size, mean or median age, gender, TNM stage of NPC, cut-off value of pretreatment serum albumin, number of high-grade cases, and duration of follow up. Then, we generated the pooled hazard ratios (HR) for overall survival (OS) and distant metastasis-free survival (DMFS) to perform this meta-analysis. RESULTS: Ten studies comprising 7,339 cases were included. Lower pretreatment serum ALB levels were significantly associated with worse OS (HR=1.32, 95% CI 1.17-1.48) and DMFS (HR=1.40, 95% CI 1.08-1.80). In general, our findings were further verified in the subgroup analyses based on three features, including cancer stage, cut-off value and analysis type. CONCLUSION: A decreased level of pretreatment serum albumin implies a poor prognosis and can be detected to define the risk stratification of NPC patients.

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