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1.
Artigo em Inglês | MEDLINE | ID: mdl-34637271

RESUMO

Electrochromic devices (ECDs) exhibiting tunable optical and thermal modulation in the infrared (IR) region have attracted extensive attention in recent years due to their attractive application prospects in both military and civilian settings. However, considering the continuous energy supply needed for driving the device operation, it is desired to develop advanced IR-ECDs with low energy consumption. Herein, a flexible self-driven IR-ECD is constructed for achieving variable optical and thermal management in a low-energy mode. In this device, a built-in potential difference of 1.36 V exists between the EC polyaniline cathode and the aluminum foil anode. Consequently, there is a rapid and obvious increase in the IR reflectance of the device after connecting the two electrodes. Such a self-driven reflectance contrast is over 20% at the wavelength of 1500 nm, and the coloration efficiency of the device reaches up to 93.6 cm2 C-1. Meanwhile, the maximum apparent temperature modulation on the surface of the device reaches up to 5.6 °C. Then, the self-driven IR-ECD could recover to its original state driven by a solar cell, indicating good reversibility and stability. We anticipate that this work may provide a new insight into developing advanced self-driven IR-ECDs for applications in dynamic military camouflage and commercial thermal control.

2.
Biomed Chromatogr ; : e5266, 2021 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-34648200

RESUMO

Podophyllotoxin (POD), a natural lignan distributed in podophyllum species, has significant antitumor and antiviral activities. But POD often causes serious side effects, such as myelosuppression, gastrointestinal toxicity, neurotoxicity, hepatic and renal dysfunction, and even death, which not only hinder its clinical application but also threaten the patient's health. Therefore, an effective treatment against POD-induced toxicity is of great importance. Our preliminary study found that the total saponins from the stems and leaves of Panax quinquefolius L. (PQS) could significantly reduce the death of mice caused by POD. To reveal how can PQS alleviate POD-induced toxicity, the further study was needed. Peripheral blood cells analysis, diarrhea score and histological examination demonstrated that PQS could relieve myelosuppression and gastrointestinal side effects induced by POD. Then, metabolomics was performed to investigate the possible protective mechanism of PQS on POD-induced myelosuppression and gastrointestinal toxicity. Metabolomics analysis showed that metabolic changes caused by POD could be reversed by PQS in some content. 23 metabolites altered significantly after POD exposure, and 11 metabolites could be significantly reversed by PQS pre-treatment. Metabolic pathway analysis suggested that PQS might play its protective effects by rebalancing disordered arginine, glutamine and unsaturated fatty acids metabolisms.

3.
Appl Opt ; 60(27): 8258-8266, 2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34612922

RESUMO

An acoustic graphene plasmon (AGP) resonator based on gold nanowire arrays structure is proposed in this paper. The resonator is designed by continuous graphene layer/gold nanowire arrays/optical resonant cavity. The infrared light excites the AGP in the graphene/gold arrays structure and propagates along the graphene surface. The coupling efficiency can be improved by the optical resonator cavity. The finite-difference time-domain method is used to simulate and optimize the property of the resonator. The results show that the resonator has a stronger optical limiting effect and higher coupling efficiency. The AGPs are a prospective platform that enhances light-matter interactions, reduces spread loss, and exhibits a double resonance absorption phenomenon in the studied mid-infrared wavelength range. The research results provide a basis for the design of optoelectronic devices and more.

4.
Clin Chim Acta ; 523: 247-259, 2021 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-34626603

RESUMO

BACKGROUND: Immunological monitoring plays a crucial role in organ recipients for allowing tailoring of immunosuppression. However, there is still a paucity of promising indicators for detecting immune status in recipients. METHODS: We conducted a prospective study to characterize the immune status by detecting dynamically lymphocyte subsets and function (represented by the abilities to secrete IFN-γ) in the first 6 months posttransplant in renal recipients. Participants were classified into an immune stable group, infected group, and rejected group. RESULTS: In the stable group, our study suggested that the counts and function of CD4+ T, CD8+ T, and NK lymphocytes decreased to their nadir at week 2, and thereafter these indicators were gradually restored. The counts exceeded pre-operative levels, whereas function did not reach the pre-transplant levels by 6 months. We demonstrated that function of lymphocytes was considerably decreased in infected recipients compared with the stable group when infection occurred. By contrast, the function of lymphocytes was obviously increased at the point of rejection. Receiver operating characteristic (ROC) analysis in the combination of subsets and function of lymphocytes presented a superior clinical value with an area under the curve (AUC) of 0.903 in the diagnosis of infected receivers, and IFN-γ+CD8+ T cells% is the highest indicator with the auROC curve of 0.862. Another ROC analysis confirmed that IFN-γ+CD4  T cells% presented a preferable diagnostic value with an area of 0.887 for rejected recipients. CONCLUSIONS: In conclusion, the ability of lymphocyte subsets secreting IFN-γ may provide a promising assessment of immune status in recipients and allow timely modifying immunosuppression.

5.
Biomed Res Int ; 2021: 5857092, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34651047

RESUMO

Over 10% of patients diagnosed with cervical intraepithelial neoplasia (CIN) have no lesions detected in their cervical conization specimens. The purpose of this study was to determine the factors related to the absence of such lesions. We particularly sought to investigate whether the expression of B7-H4 in precancerous lesions and cancer of the uterine cervix plays a role in the presence or absence of residual lesions in conization specimens and whether this protein is associated with T cells (i.e., Foxp3+ regulatory T cells, CD4+, and CD8+) and interferon-γ production. Of the 807 patients with CIN treated by conization, 104 (12.9%) had no lesions in their conization specimens. Seventy-five of these patients were deemed the study group and were matched with 75 patients who did have CIN detected in their conization specimens (the control group). Immunohistochemistry and immunofluorescence staining were used to detect B7-H4, Foxp3, CD4, CD8, and interferon-γ in the 75 pairs of specimens obtained via biopsy; 20 samples were found to have chronic cervicitis, and another 20 had squamous cell carcinoma of the cervix. Menopause, the absence of human papillomavirus, low-grade histological findings, and a diagnosis of CIN1 and CIN2 on biopsy correlated with a low probability of lesions on conization specimens. B7-H4 expression was detected in 11.1% of CIN2, 46.6% of CIN3, and 70% of cervical cancer samples, but not in tissues representing chronic cervicitis or CIN1. B7-H4 expression was associated with the presence of lesions on conization specimens, increased regulatory T cells, decreased CD8+ T cells, and lower interferon-γ production. These data suggest that close follow-up and thorough reevaluation should be considered for patients diagnosed with CIN2 who are negative for B7-H4 expression on biopsy before proceeding with cervical conization.

6.
Artigo em Inglês | MEDLINE | ID: mdl-34515012

RESUMO

BACKGROUND: Breast cancer is one of the most common cancers worldwide among women, and angiogenesis has an important effect on its growth and metastasis. Glipizide, which is a widely used drug for type 2 diabetes mellitus, has been reported to inhibit tumor growth and metastasis by upregulating the expression of natriuretic peptide receptor A (NPRA). Atrial natriuretic peptide (ANP), the receptor of NPRA, plays an important role in angiogenesis. The purpose of this study was to explore the effect of glipizide combined with ANP on breast cancer growth and metastasis. METHODS: To investigate the effect of glipizide combined with ANP on breast cancer, glipizide, ANP or glipizide combined with ANP was intraperitoneally injected into MMTV-PyMT mice. To explore whether the anticancer efficacy of glipizide combined with ANP was correlated with angiogenesis, a tube formation assay was performed. RESULTS: Glipizide combined with ANP was found to inhibit breast cancer growth and metastasis in MMTV-PyMT mice, which spontaneously develop breast cancer. Furthermore, the inhibitory effect of ANP combined with glipizide was better than that of glipizide alone. ANP combined with glipizide significantly inhibited tube formation of human umbilical vein endothelial cells (HUVECs) by suppressing vascular endothelial growth factor (VEGF)/VEGFR2 (vascular endothelial growth factor receptor 2) signaling. CONCLUSIONS: These results demonstrate that glipizide combined with ANP has a greater potential than glipizide alone to be repurposed as effective agents for the treatment of breast cancer by targeting tumor-induced angiogenesis.

7.
Protein Cell ; 2021 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-34554412

RESUMO

New threats posed by the emerging circulating variants of SARS-CoV-2 highlight the need to find conserved neutralizing epitopes for therapeutic antibodies and efficient vaccine design. Here, we identified a receptor-binding domain (RBD)-binding antibody, XG014, which potently neutralizes ß-coronavirus lineage B (ß-CoV-B), including SARS-CoV-2, its circulating variants, SARS-CoV and bat SARSr-CoV WIV1. Interestingly, antibody family members competing with XG014 binding show reduced levels of cross-reactivity and induce antibody-dependent SARS-CoV-2 spike (S) protein-mediated cell-cell fusion, suggesting a unique mode of recognition by XG014. Structural analyses reveal that XG014 recognizes a conserved epitope outside the ACE2 binding site and completely locks RBD in the non-functional "down" conformation, while its family member XG005 directly competes with ACE2 binding and position the RBD "up". Single administration of XG014 is effective in protection against and therapy of SARS-CoV-2 infection in vivo. Our findings suggest the potential to develop XG014 as pan-ß-CoV-B therapeutics and the importance of the XG014 conserved antigenic epitope for designing broadly protective vaccines against ß-CoV-B and newly emerging SARS-CoV-2 variants of concern.

8.
Environ Monit Assess ; 193(10): 655, 2021 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-34532779

RESUMO

Heavy metals' pollution of agricultural soil is an environmental problem of widespread concern, especially in China, but, how to accurately identify their sources is still a great challenge. Here, we implemented a high-density sampling strategy (2194 samples collected) and combined correlation analysis (CA), principal component analysis (PCA), positive matrix factorization (PMF) modeling, and geostatistical analyses to identify and quantify the source contributions of heavy metals in agricultural soil in a key commodity grain base of China. The results showed that the excess risk rate of Cd was the highest (4.3%), and contributing to 42.7% of the total potential ecological risk in the region. Hence, Cd is the most important ecological risk factor. Heavy metals in the region mainly originated from oil extraction and smelting (7.5%), parent materials and traffic emissions (59.2%), coal-related industrial activities (11.6%), and agricultural sources (21.7%). Cd was mainly derived from oil extraction and smelting (90.1%). As (73.6%), Cr (90.3%), and Pb (67.1%) were closely associated with parent materials and traffic emissions. Hg (87.7%) was mainly originated from coal-related industrial sources. In addition, As (25.6%) and Pb (24.3%) were also from agricultural sources (such as fertilizer, pesticides, and manure). This study confirms that the combination of these methods can accurately identify the sources of heavy metals in agricultural soil. These findings can assist governmental agencies in implementing targeted control strategies to prevent the spread of heavy metals.


Assuntos
Metais Pesados , Poluentes do Solo , China , Monitoramento Ambiental , Metais Pesados/análise , Análise de Componente Principal , Medição de Risco , Solo , Poluentes do Solo/análise
9.
J Clin Psychiatry ; 82(6)2021 09 21.
Artigo em Inglês | MEDLINE | ID: mdl-34551222

RESUMO

Objective: Dyslipidemia is a controversial risk for Alzheimer's disease (AD) with unknown mechanisms. This study aimed to investigate polygenic effects of the lipid metabolic pathway on cerebrospinal fluid (CSF) core biomarkers, cognition, and default mode network (DMN).Methods: Cross-sectional data on serum lipids, CSF core biomarkers, and functional MRI findings for 113 participants (25 cognitively normal, 20 with subjective cognitive decline, 24 early amnestic, 23 with late mild cognitive impairment, and 21 with AD) from the Alzheimer's Disease Neuroimaging Initiative were included. Different cognitive stages were categorized based on neuropsychological assessments. Multivariable linear regression analyses were conducted to investigate the polygenic and interactive effects on the DMN. The correlations of lipid-related polygenes and serum lipids with cognitive performance were also studied via regression analyses.Results: The polygenic scores were significantly correlated with CSF levels of core biomarkers (P < .05) but not with cognition. Several serum lipids were associated with total tau. CSF core biomarkers and 6 serum lipids both could impact cognition in a nonlinear manner. Polygenic effects exhibited diverse trajectories on the DMN subsystems across the AD spectrum. Extensive genetic and interactive effects were mainly concentrated in the cortical frontal-parietal network and subcortical regions. Brain regions of lipid metabolites linking to DMN involved sensorimotor network and occipital lobe.Conclusions: Polygenic effects of the lipid metabolic pathway could accelerate pathological changes and disrupted DMN subsystem trajectory across the AD spectrum. These results deepen the understanding of the mechanism of lipid metabolism affecting the neural system and provide several lipid indicators that enable the impairments of lipid metabolism on the brain to be monitored.

10.
Environ Pollut ; 291: 118116, 2021 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-34537597

RESUMO

Real-time river chloride prediction has received a lot of attention for its importance in chloride control and management. In this study, an artificial neural network model (i.e., multi-layer perceptron, MLP) and a statistical inference model (i.e., stepwise-cluster analysis, SCA) are developed for predicting chloride concentration in stream water. Then, an ensemble learning model based on MLP and SCA is proposed to further improve the modeling accuracy. A case study of hourly river chloride prediction in the Grand River, Canada is presented to demonstrate the model applicability. The results show that the proposed ensemble learning model, MLP-SCA, provides the best overall performance compared with its two ensemble members in terms of RMSE, MAPE, NSE, and R2 with values of 11.58 mg/L, 27.55%, 0.90, and 0.90, respectively. Moreover, MLP-SCA is more competent for predicting extremely high chloride concentration. The prediction of observed concentrations above 150 mg/L has RMSE and MAPE values of 9.88 mg/L and 4.40%, respectively. The outstanding performance of the proposed MLP-SCA, particularly in extreme value prediction, indicates that it can provide reliable chloride prediction using commonly available data (i.e., conductivity, water temperature, river flow rate, and rainfall). The high-frequency prediction of chloride concentration in the Grand River can supplement the existing water quality monitoring programs, and further support the real-time control and management of chloride in the watershed. MLP-SCA is the first ensemble learning model for river chloride prediction and can be extended to other river systems for water quality prediction.

11.
Cells ; 10(9)2021 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-34571893

RESUMO

Uric acid (UA) is the end-product in the human purine metabolism pathway. The UA that accumulates in silkworm tissues is excreted as a nitrogen waste product. Here, we first validated that Bombyx mori has a homolog of the human gene that encodes the 5'-nucleotidase (5'N) involved in purine metabolism. The B. mori gene, Bm5'N, is located upstream of other genes involved in UA metabolism in the silkworm. Disruption of Bm5'N via the CRISPR/Cas9 system resulted in decreased UA levels in the silkworm epidermis and caused a translucent skin phenotype. When Bm5'N mutant silkworms were fed with the uric acid precursor inosine, the UA levels in the epidermis increased significantly. Furthermore, the metabolomic and transcriptomic analyses of Bm5'N mutants indicated that loss of the Bm5'N affected purine metabolism and the ABC transport pathway. Taken together, these results suggest that the UA pathway is conserved between the silkworm and humans and that the Bm5'N gene plays a crucial role in the uric acid metabolism of the silkworm. Thus, the silkworm may be a suitable model for the study of UA metabolism pathways relevant to human disease.

12.
Environ Sci Technol ; 55(18): 12459-12470, 2021 09 21.
Artigo em Inglês | MEDLINE | ID: mdl-34514800

RESUMO

Agricultural plastic films have been proven highly advantageous, but they also cause pollution of plastic debris and associated chemicals. Phthalates (phthalic acid esters, PAEs), an important additive of agricultural films, can be released and contaminate the environment. Here, we analyzed the agricultural plastic usage and assessed plastic debris in China and developed a method to estimate PAE emissions from agricultural films. Additionally, the environmental fate of PAEs was evaluated using a fugacity-based multimedia model. The agricultural plastic film usage in China in 2017 was 2,528,600 tons. After agricultural film recycling and water erosion, the plastic debris amount was estimated as 465,016 tons. The water erosion process carried 4329 tons of plastic debris into the aquatic environment. During its lifetime, the agricultural film released a total of 91.5 tons of two typical types of PAEs. PAEs from the mulching film would mostly be removed through degradation, while those from the greenhouse film accumulate in vegetables. Populated regions exhibited more serious PAE pollution in vegetables but with no immediate health risks. The model was well evaluated using comparable measured concentrations and uncertainty analysis based on the Monte Carlo method. The findings from this study demonstrate the serious agricultural plastic pollution problem and associated PAE contamination in China.


Assuntos
Ácidos Ftálicos , Poluentes do Solo , China , Ésteres , Plásticos , Poluentes do Solo/análise
13.
Nanoscale Horiz ; 2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34542134

RESUMO

Treating cancer with high efficacy while eliminating side effects has been the holy grail of cancer research. The challenge, however, arises from the similarity in molecular traits of cancer cells and normal cells because truly specific cancer biomarkers are extremely scarce if not entirely unavailable. Often, biomarkers serving as the therapeutic targets are present on both healthy cells and cancers, but at different levels, causing not only off-target side effects but also on-target side effects. This work has reported a new concept of cancer treatment, spatial confinement of cells to inhibit cell migration and invasion, which directly addresses the defining trait of cancer on the cellular level, unchecked division. Using large sized graphene oxide (LS-GO), cell surfaces can be patched. Unlike conventional chemotherapy, this spatial confinement does not affect the viability of non-dividing cells but significantly inhibits tumor cell migration and invasion in vitro and in vivo. This new concept has the potential to become a general therapeutic for many cancer types with reduced side effects.

14.
World J Surg Oncol ; 19(1): 247, 2021 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-34416888

RESUMO

BACKGROUND: Previous studies had shown that microRNA-638 (miR-638) exhibited different effects in malignant tumors. Moreover, the function of miR-638 has not been reported in breast cancer. Hence, we designed this research to explore the function of miR-638 in breast cancer. METHODS: Firstly, miR-638 expressions were measured in breast cancer tissues via RT-qPCR. Protein expressions were detected through immunocytochemical (IHC) assay and western blot analysis. Then, Cell Counting Kit-8 (CCK-8) assay and Transwell assay were conducted to observe proliferation and motility of the cells. Dual luciferase assay was performed to confirm the binding site between miR-638 and Homeobox protein Hox-A9 (HOXA9). RESULTS: Reduced expression of miR-638 was detected in breast cancer. And low miR-638 expression was related to poor prognosis in patients with breast cancer. Functionally, the viability, migration, and invasion of the breast cancer cells were suppressed by miR-638 overexpression. Furthermore, miR-638 can directly bind to HOXA9, and increased expression of HOXA9 was also detected in breast cancer. In particular, HOXA9 upregulation can impair anti-tumor effect of miR-638 in breast cancer, and miR-638 can hinder the Wnt/ß-cadherin pathway and epithelial-mesenchymal transition (EMT) in breast cancer. CONCLUSION: miR-638 inhibits breast cancer progression through binding to HOXA9.


Assuntos
Neoplasias da Mama , Proteínas de Homeodomínio , MicroRNAs , Neoplasias da Mama/genética , Caderinas/genética , Linhagem Celular Tumoral , Movimento Celular , Proliferação de Células , Feminino , Proteínas de Homeodomínio/genética , Humanos , MicroRNAs/genética , Prognóstico
15.
Am J Health Behav ; 45(4): 701-710, 2021 07 26.
Artigo em Inglês | MEDLINE | ID: mdl-34340737

RESUMO

Objectives: Information and communication technology (ICT) has emerged as an appealing approach to address the changing life satisfaction of the aging population. This study explores the influence of perceived benefit and social support on the life satisfaction of elderly individuals via the mediation of their ICT use, from a motivation perspective. Additionally, we explore the moderating effect of health consciousness on the relationship between perceived benefit, social support and ICT use for the elderly. Methods: Using 237 valid samples from elderly individuals in China, we conducted a survey to evaluate their ICT use, perceived benefit, social support and life satisfaction. Results: Perceived benefit and social support both can influence life satisfaction of elderly individuals, and the effects of these factors are mediated by elderly ICT use. Furthermore, health consciousness can moderate the relationship among perceived benefit, social support and ICT use for the elderly. Conclusions: Both intrinsic and extrinsic motivations can influence ICT use by elderly individuals as well as their life satisfaction. ICT use plays an important role in life satisfaction for elderly people, and their individual health consciousness is a crucial factor.

16.
J Int Med Res ; 49(8): 3000605211031776, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34369193

RESUMO

The probability of rhabdomyosarcoma occurring in the cervix is less than 0.5% and may be associated with a pathogenic dicer 1, ribonuclease III (DICER1) gene variation. Tumour-induced hypercoagulability and high levels of cancer antigen (CA) 125 are risk factors for cerebral venous sinus thrombosis (CVST). In addition, although nonpuerperal uterine inversion is very rare and is usually caused by leiomyomas from the uterus, large cervical masses can also be the cause. This case report describes a 24-year-old woman with uterine inversion caused by an embryonic cervical rhabdomyosarcoma that presented with CVST as her first symptom. The patient underwent laparoscopic total uterus and bilateral salpingectomy, during which the uterus was found to be completely inverted. Postoperative pathology confirmed embryonic cervical rhabdomyosarcoma. The patient quickly developed lung and para-aortic lymph node metastases. Two months later, the patient died of complications. When coagulation indices in patients with tumours are abnormal, especially when the levels of D-dimer and CA125 increase, it is recommended that anticoagulant therapy is administered in a timely manner to prevent the occurrence of CVST. Furthermore, for large cervical tumours, physicians should also be alert to the occurrence of uterine inversion.


Assuntos
Rabdomiossarcoma , Trombose dos Seios Intracranianos , Neoplasias do Colo do Útero , Inversão Uterina , Adulto , RNA Helicases DEAD-box , Feminino , Humanos , Gravidez , Ribonuclease III , Trombose dos Seios Intracranianos/complicações , Trombose dos Seios Intracranianos/diagnóstico por imagem , Neoplasias do Colo do Útero/complicações , Adulto Jovem
17.
Sci Total Environ ; 790: 148194, 2021 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-34380251

RESUMO

Fluoroquinolones (FQs) have raised significant concerns due to their ubiquitous occurrence and promoting of antimicrobial resistance (AMR). In this study, a molecularly imprinted polymer-diffusive gradient in thin-films (MIP-DGT) sampler is developed for selective measurement of FQs in waters by using a commercial available MIP material as the binding agent. The MIP-DGT shows selective adsorption of the FQs and linearly accumulates the FQs over the deployment time. MIP-DGT measurement is independent of pH (6-8) and ionic strength (IS) (0.01-0.5 M) but is affected by DOM at higher concentrations (~10 mg•L-1), which is due to the altered diffusion coefficients and reduced adsorption on the MIP binding gel. Significant interaction effects of DOM with pH or IS indicate that this is the predominant influence on the MIP-DGT performance, which results in a lower measurement by the MIP-DGT but this is curtailed to some extend with increasing IS or pH. The MIP-DGT measurements, however, correlate well with those by grab sampling in a wastewater treatment plant, suggesting it is reliable for measuring FQs in waters. For the first time, we demonstrate that key water chemistry parameters do have interaction effects on the DGT measurements, which should be considered for the data interpretation. The MIP-DGT is a promising tool to understand the interaction effects of the environmental parameters on the fate, behaviours and bioavailability/toxicity of organic contaminants and improve environmental risk assessments in the environment and modelling.


Assuntos
Monitoramento Ambiental , Poluentes Químicos da Água , Antibacterianos/análise , Difusão , Fluoroquinolonas , Polímeros Molecularmente Impressos , Poluentes Químicos da Água/análise
18.
CNS Neurosci Ther ; 2021 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-34415671

RESUMO

INTRODUCTION: The blood-brain barrier (BBB) disruption contributes to postoperative delirium, but cost-effective and non-invasive assessment of its permeability is not practicable in the clinical settings. Urine albumin to creatinine ratio (UACR), reflecting systemic vascular endothelial dysfunction, may be a prognostic and predictive factor associated with postoperative delirium. The aim was to analyze the relationship between UACR and postoperative delirium in elderly patients undergoing elective non-cardiac surgery. MATERIALS AND METHODS: Through stratified random sampling, a cohort of 408 individuals aged 60 years and older scheduled for elective non-cardiac surgery were included between February and August 2019 in the single-center, prospective, observational study. The presence of delirium was assessed using the Confusion Assessment Method (CAM) or Confusion Assessment Method for the ICU (CAM-ICU) on the day of surgery, at 2 h after the surgery ending time and on the first 3 consecutive days with repeated twice-daily, with at least 6-h intervals between assessments. Urine samples were collected on one day before surgery, and 1st day and 3rd day after surgery. The primary outcome was the presence of postoperative delirium, and association of the level of UACR with postoperative delirium was evaluated with unadjusted/adjusted analyses and multivariable logistic regression. RESULTS: Postoperative delirium was observed in 26.75% (107 of 400) of patients within 3 days post-surgery. UACR-Pre (OR, 1.30; 95% CI, 1.14-1.49, p < 0.001), UACR-POD1 (OR, 1.20; 95% CI, 1.13-1.27, p < 0.001), and UACR-POD3 (OR, 1.14; 95% CI, 1.08-1.20, p < 0.001) between the delirium and non-delirium groups show a significant difference, even after adjusting for age, education levels, and other factors. CONCLUSION: As the marker of endothelial dysfunction, the high perioperative UACR value may be linked to the postoperative delirium in elderly patients undergoing elective non-cardiac surgery.

19.
Support Care Cancer ; 2021 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-34363109

RESUMO

BACKGROUND: Frailty is emerging as an important determinant for health. Compared with Western countries, research in the field of frailty started at a later stage in China and mainly focused on older community dwellers. Little is known about frailty in Chinese cancer patients, nor the risk factors of frailty. This study aimed at investigating the prevalence of frailty and its risk factors in elderly inpatients with gastric and colorectal cancer. METHODS: This cross-sectional study was conducted at a tertiary hospital in China from Mar. 2020 to Nov. 2020. The study enrolled 265 eligible inpatients aged 60 and older with gastric and colorectal cancer who underwent surgery. Demographic and clinical characteristics, biochemical laboratory parameters, and anthropometric data were collected from all patients. The Groningen Frailty Indicator was applied to assess the frailty status of patients. A multivariate logistic regression model analysis was performed to identify the risk factors of frailty and to estimate their 95% confidence intervals. RESULTS: The prevalence of frailty in elderly inpatients with gastric and colorectal cancer was 43.8%. A multivariate logistic regression analysis showed that older age (OR = 1.065, 95% CI: 1.001-1.132, P = 0.045), low handgrip strength (OR = 4.346, 95% CI: 1.739-10.863, P = 0.002), no regular exercise habit (OR = 3.228, 95% CI: 1.230-8.469, P = 0.017), and low MNA-SF score (OR = 11.090, 95% CI: 5.119-24.024, P < 0.001) were risk factors of frailty. CONCLUSIONS: This study suggested a relatively high prevalence of frailty among elderly inpatients with gastric and colorectal cancer. Older age, low handgrip strength, no regular exercise habit, and low MNA-SF score were identified as risk factors of frailty.

20.
Mater Horiz ; 8(1): 12-32, 2021 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-34463695

RESUMO

Lithium metal battery (LMB) is considered to be one of the most promising electrochemical energy storage devices due to the high theoretical specific capacity and the lowest redox potential of metallic lithium; however, some key issues caused by lithium dendrites on the lithium metal anode seriously hinder its real-world applications. As an indispensable part of LMBs, the separator could serve as a physical barrier to prevent direct contact of the two electrodes and control ionic transport in batteries; it is an ideal platform for the suppression of lithium dendrites. In this review, the mechanism of lithium dendrite nucleation and growth are firstly discussed and then some advanced techniques are introduced for the precise characterization of lithium dendrites. On the basis of dendritic nucleation and growth principle, several feasible strategies are summarized for suppressing lithium dendrites by utilizing functional separators, including providing a mechanical barrier, promoting homogeneous lithium deposition, and regulating ionic transport. Finally, some challenges and prospects are proposed to clear the future development of functional separators. We anticipate that this paper will provide a new insight into the design and construction of functional separators for addressing the issues of lithium dendrites in high-energy batteries.

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