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1.
Arch Osteoporos ; 15(1): 49, 2020 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-32189157

RESUMO

INTRODUCTION: Observational studies have shown that tea consumption has a potentially beneficial effect on bone health. However, few studies have assessed the effects of types of tea consumed on bone health. We aimed to investigate whether drinking oolong tea is associated with increased calcaneus bone mineral density (BMD) in postmenopausal women. METHODS: From an epidemiological survey in Shantou, 476 postmenopausal women aged 40 to 88 years were enrolled in the study. All women were questioned about their demographic features, lifestyle, health status, types of tea consumed, habit of tea consumption, and habitual dietary intake by use of a structured questionnaire. Estimated areal BMD was measured by calcaneal quantitative ultrasound (QUS). RESULTS: As compared with non-tea drinkers, oolong tea drinkers had higher calcaneus BMD (ß 34.70 [95% CI 10.38, 59.03]). In addition, calcaneus BMD was significantly increased for those drinking 1-5 cups/day (ß 27.43 [95% CI 3.70, 51.16]) but not > 5 cups/day. We observed no linear increase in calcaneus BMD with increasing years of tea consumption and local polynomial regression fitting showed a parabola-shaped association between years of tea consumption and calcaneus BMD. However, symptoms of osteoporosis did not differ by types of tea consumed. CONCLUSION: Long-term moderate oolong tea consumption may have beneficial effects on bone health in postmenopausal women in Shantou of southern China.

2.
Phytochemistry ; 172: 112260, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31982646

RESUMO

Six undescribed quinoline alkaloids, named dasycarines A-E, and 18 known ones were isolated from the root bark of Dictamnus dasycarpus. All the structures were elucidated on the basis of comprehensive analysis of UV, IR, NMR, and HRMS spectroscopic data, and the absolute configurations were assigned via comparison of the calculated and experimental ECD data. (+)-Dasycarine A (1a) and (-)-Dasycarine A (1b) are a pair of enantiomers of dimeric furoquinoline alkaloid, which are the first dimeric via [2 + 2] cycloaddition of furan. The structure and absolute configuration of (-)-dasycarine A was determined via X-ray crystallography. Additionally, all the isolated compounds were tested for their inhibitory effects on NO production stimulated by LPS in BV-2 microglial cells. Three compounds showed strong inhibition with IC50 values below 5.0 µM; nine compounds exhibited inhibition with IC50 values in the range of 7.8-28.4 µM. Furthermore, we demonstrated that preskimmianine suppressed the levels of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and nuclear factor kappa B (NF-κB) in LPS-induced BV-2 microglial cells.


Assuntos
Alcaloides , Dictamnus , Quinolinas , Anti-Inflamatórios , Casca de Planta
3.
Eur J Clin Nutr ; 2020 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-31932742

RESUMO

BACKGROUND/OBJECTIVES: The results linking body iron stores to the risk of gestational diabetes mellitus (GDM) are conflicting. We aimed to measure the serum ferritin level of women in early pregnancy and evaluate the risk of GDM in a Chinese urban population. SUBJECTS/METHODS: In total, 851 pregnant women between 10 and 20 weeks of gestation took part in the prospective, observational study conducted. The women were divided into four groups by quartiles of serum ferritin levels (Q1-4). Their blood samples were collected and assayed for several biochemical variables at the beginning of the study, and the women were followed up with a 75-g oral glucose tolerance test at 24-28 weeks of gestation. RESULTS: The participants had an average serum ferritin concentration of 65.67 µg/L. GDM prevalence within each serum ferritin quartile was 9.4%, 14.6%, 18.8% and 19.3%, respectively, (P = 0.016). The odds ratio for GDM in the ferritin Q2-4 was 1.64 (CI: 0.90-2.99), 2.23 (CI: 1.26-3.96) and 2.31 (CI: 1.30-4.10), compared with Q1, respectively. This association persisted after adjusting for potential confounders factors. In addition, in Q4, pregnant women with a pre-pregnancy body mass index ≥24 kg/m2, maternal age ≤35 years old or haemoglobin≥ 110 g/L did have an increased risk of developing GDM. CONCLUSIONS: Elevated serum ferritin concentrations in early gestation are associated with an increased risk of GDM, especially in pregnant women who have a high baseline iron storage status with no anaemia or who are overweight/obese. Individual iron supplementation should be considered to minimize the risk of GDM.

4.
Environ Int ; 135: 105410, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31884132

RESUMO

BACKGROUNDS: Evidence is scarce on the relation between maternal exposure to ambient air pollution during pregnancy and fetal growth in developing countries. Moreover, the current evidence is inconsistent. We aimed to investigate the association of trimester-specific exposure to air pollution with risk of being born small for gestational age (SGA) and birth weight-markers of fetal growth-among Chinese term births. METHODS: This retrospective population-based cohort study consisted of 2,567,457 singleton term live-births from January 1, 2014 to December 31, 2017 across 123 Chinese districts and counties. Personal exposure to ambient air pollutants including carbon monoxide (CO), sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3), particulate matter with aerodynamic diameter < 2.5 µm (PM2.5), and PM10 was assigned using the inverse distance weighting spatial interpolation algorithm. Generalized estimating equations (GEE) logistic regression models were performed to estimate the associations between trimester-specific exposure to air pollution and risk of SGA or low birth weight (LBW), and GEE linear regression to examine the associations between the exposure and term birth weight, adjusting for maternal demographics, maternal cigarette smoking status during pregnancy, mode of delivery, gravidity, gestational age, year and month of conception, neonate's sex, and meteorological factors. Stratified and sensitivity analyses were also performed. RESULTS: When mother exposed to ambient air pollutants over the entire pregnancy, per IQR increment (0.122 mg/m3) in ambient CO concentrations was associated with higher risk of SGA (odds ratio (OR) = 1.04, 95% confidence interval (CI): 1.02, 1.05) and reduced birth weight among term births (-5.95 g, 95% CI: -8.01, -3.89). This association was also pronounced in the second and third trimesters. Term birth weight was negatively associated with per IQR increase of O3 (-3.52 g, 95% CI: -6.23, -0.81), PM2.5 (-5.93 g, 95% CI: -8.36, -3.49) and PM10 (-7.78 g, 95% CI: -10.41, -5.16) during the entire pregnancy, respectively. No significant association was detected between maternal exposure to air pollutants and term LBW. Effect estimates of heterogeneity suggested that maternal age and infant sex modified the impact of air pollution on birth weight. CONCLUSIONS: The findings suggest that maternal exposure to air pollution during pregnancy is adversely affecting fetal growth. Further studies are warranted to integrate these findings and take clinical or public health interventions in pregnancy.

5.
Sci Total Environ ; 700: 134510, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31629267

RESUMO

Manganese-oxidizing aerobic granular sludge (Mn-AGS) is a novel extension of AGS technology to treat arsenic (As) in organic wastewater. In this study, Mn-AGS was first applied to treat real wastewater (bottom ash leachates) containing high levels of As(III) and Cu(II) in a sequencing batch reactor (SBR) for 91 days. Influent and effluent As(III), As(V), Cu(II), as well as pH and chemical oxygen demand (COD) were monitored daily, and sludge was collected regularly for morphological observation, chemical characterization, and microbial analysis. The results indicated that As(III) and Cu(II) could be efficiently removed from wastewater (∼83% and ∼100%, respectively), but the performance was sensitive to pH variation, especially for As(III). The removed As and Cu were mostly bound to carbonates (60.2 ±â€¯2.0% and 70.0 ±â€¯0.6%, respectively) and Fe/Mn oxides (28.2 ±â€¯1.6% and 14.6 ±â€¯0.5%, respectively) in the final sludge. Influent As(III) was partially oxidized into As(V), and high fractions of As(V) were obtained in the Fe/Mn oxide-bound phase. Unexpectedly, microbial analysis revealed that community richness was only slightly changed when the influent was acidized (pH 4.0) but greatly reduced after the influent pH back to 6.0. It could be explained by that acid-fast bacteria rapidly grew after pH recovery and eliminated non-acid-fast bacteria. This work further supported the practical application of Mn-AGS to treat As(III)-containing organic wastewaters.


Assuntos
Arsênico/metabolismo , Cobre/metabolismo , Manganês/metabolismo , Eliminação de Resíduos Líquidos/métodos , Poluentes Químicos da Água/metabolismo , Aerobiose , Arsênico/análise , Águas Residuárias/química , Poluentes Químicos da Água/análise
6.
J Nat Prod ; 82(12): 3288-3301, 2019 Dec 27.
Artigo em Inglês | MEDLINE | ID: mdl-31804070

RESUMO

Twenty-six glucoconjugated monoterpene indole alkaloids, including 12 new compounds, rhynchophyllosides A-L (1-12), and 14 known ones, 13-26, were obtained from the hook-bearing stems of Uncaria rhynchophylla (Miq.) Miq. ex Havil. Their structures were unambiguously elucidated by analyses of UV, MS, NMR, ECD, and single-crystal X-ray diffraction data. The ESI-MSn behavior of the new glucoalkaloids was also elucidated. Although comprising the same glucosyl moiety, the aglycone skeletons and glucosidic numbers and linkage varied greatly, implying the diversity in biosynthetic pathways. This is the first report of such structurally diverse glucoconjugated monoterpene indole alkaloids from U. rhynchophylla. Compound 1 represents a new subtype of oxindole alkaloid with a seven-membered D-ring, 10 is a rare monoterpene indole alkaloid with the glucosyl moiety located at C-9, 4 and 5 are the first two oxindole alkaloid diglycosides, and 11 and 12 represent the first two examples of alkaloids with a quinolone nucleus from the genus Uncaria. Compound 10 exhibited moderate acetylcholinesterase (AChE) inhibitory activity with an IC50 value of 10.5 µM. Molecular docking was performed to explore the binding mode of inhibitor 10 at the active site of AChE.

7.
Int J Chron Obstruct Pulmon Dis ; 14: 2319-2329, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31632001

RESUMO

Background: Chronic obstructive pulmonary disease (COPD) is recognized as a chronic lung disease with incomplete reversible airflow limitation, but its pathophysiology was still not clear. This study aimed at investigating regulatory roles of special miRNA-mRNA axis in COPD development. Methods: Differentially expressed miRNAs and downstream mRNAs were screened from the Gene Expression Omnibus (GEO) dataset by using the LIMMA package in R software. Weighted Gene Co-expression Network Analysis (WGCNA) was used to construct a co-expression network for COPD. The correlation of dysregulated miRNA(s) and COPD was analyzed, and miRNAs with significant differences were validated in peripheral blood mononuclear cells (PBMCs) from COPD patients by real-time PCR. Regulatory roles of candidate miRNAs and targeted mRNAs were investigated in vitro study. Results: Thirteen modules of co-expressed miRNAs and mRNAs were constructed from a selected cohort with WGCNA. Turquoise module with 12 differentially expressed miRNAs and 120 mRNAs was significantly correlated with COPD. The expression of hsa-miR-664a-3p, an upregulated miRNA in the module, was increased both in lung tissue and PBMCs from COPD patients, whereas that targeted four and a half LIM domains 1 (FHL1) gene was decreased and positively correlated with forced expiratory volume in 1 sec (FEV1)/forced vital capacity (FVC%) (r = 0.59, p < 0.01). In vitro, luciferase activity assay revealed FHL1 as a target of hsa-miR-664a-3p and it could be directly downregulated by overexpression of hsa-miR-664a-3p. Furthermore, cigarette smoke extract could increase hsa-miR-664a-3p level and decrease FHL1 level in Beas-2B cells. Conclusion: The present study validated significant upregulation of hsa-miR-664a-3p in COPD patients, and its target gene FHL1 was downregulated and positively correlated with FEV1/FVC%; both hsa-miR-664a-3p and FHL1 could be regulated by cigarette smoke extract. Results of bioinformatic analyses and expanded validation suggest that the axis from hsa-miR-664a-3p to FHL1 might play a key role in cigarette smoke-induced COPD, and the exact mechanism should be confirmed in further studies.

8.
Sci Total Environ ; 690: 417-425, 2019 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-31299574

RESUMO

Organic micropollutants (OMPs) are frequently detected in water and wastewater, and have attracted wide attention due to potential adverse effects on ecosystems and human health. In this work, manganese-oxidizing aerobic granular sludge (Mn-AGS) was successfully cultivated and applied to remove OMPs from wastewater. Biogenic manganese (III,IV) oxides (bio-MnOx) were generated and accumulated to 22.0-28.3 mg Mn/g SS in the final sludge. Neither the addition of allochthonous manganese-oxidizing bacteria (MnOB; Pseudomonas putida MnB1) nor the reduction in hydraulic retention time (HRT) facilitated the cultivation of Mn-AGS. Batch experiments of OMPs degradation indicated that Mn-AGS significantly improved (1.3-3.9 times) degradation rates of most OMPs. Removal rates of bisphenol A (BPA), 17α­ethinylestradiol (EE2), tetracycline (TC), and chloramphenicol (CAP) were 3.0-12.6 µg/h/g SS by the traditional AGS and 8.0-16.3 µg/h/g SS by Mn-AGS; those of imazethapyr (IM) were relatively high, 64.7 ±â€¯0.1 and 127.8 ±â€¯2.5 µg/h/g SS by AGS and Mn-AGS, respectively. However, degradation of dichlorophenyl phosphine (DCPP) was slower by Mn-AGS than AGS, 9.0 ±â€¯0.4 vs. 21.2 ±â€¯0.9 µg/h/g SS, possibly due to inhibition of microbial activity by bio-MnOx. This work provides a promising method for treating OMPs in organic wastewater, but the possible inhibition of microbes by bio-MnOx should be noted.

9.
Chemosphere ; 236: 124353, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31319307

RESUMO

As, Sb, and Cr are redox-sensitive and toxic heavy metal(loid)s, and redox reactions are usually involved in the treatment of substrates containing these elements. In this study, manganese-oxidizing aerobic granular sludge (Mn-AGS) was obtained by continuously adding Mn(II) to the sludge in a sequencing batch reactor (SBR). Morphological observations, and analyses of extracellular polymeric substances (EPS), Mn valence-states, and microbial communities were performed on the resulting sludge. After 50 days of cultivation, biogenic Mn(III,IV) oxides (bio-MnOx) accumulated up to approximately 25 mg Mn/g suspended solids (SS). X-ray photoelectron spectroscopy (XPS) revealed that the percentage of Mn(III,IV) was 87.6%. The protein (PN) component in EPS increased from 80.3 to 87.8 mg/g volatile suspended solids (VSS) during cultivation, which might be favorable for sludge granulation and heavy metal(loid) removal. Batch experiments showed that Mn-AGS was better at oxidizing As(III)/Sb(III) into less toxic As(V)/Sb(V) than traditional AGS. Remarkably, the results indicated that Mn-AGS did not oxidize Cr(III) but was able to reduce Cr(VI) into relatively harmless Cr(III). This work provided a new promising method with which to treat As(III), Sb(III), and Cr(VI) in wastewaters.


Assuntos
Antimônio/análise , Arsênico/análise , Cromo/análise , Manganês/química , Esgotos/química , Purificação da Água/métodos , Reatores Biológicos , Oxirredução
10.
J Asian Nat Prod Res ; : 1-8, 2019 May 30.
Artigo em Inglês | MEDLINE | ID: mdl-31144510

RESUMO

Three new compounds (1-3), named dasycarine G (1), dasycarether (2), and dasycarester (3), along with seven known compounds (4-10) obtained from the genus Dictamnus for the first time, were isolated from the root bark of Dictamnus dasycarpus. Their structures were elucidated on the basis of spectroscopic data (UV, IR, HR-ESI-MS, 1D and 2D NMR, and CD). In the in vitro assay, compounds 1, 5, 6, 9, and 10 exhibited NO inhibitory effects of LPS-induced BV-2 cells with IC50 values in the range of 10.4 µM to 27.2 µM.

11.
BMJ Open ; 9(5): e024197, 2019 05 24.
Artigo em Inglês | MEDLINE | ID: mdl-31129573

RESUMO

OBJECTIVE: Dengue is a mosquito-transmitted virus infection that remains rampant across the tropical and subtropical areas worldwide. However, the spatial and temporal dynamics of dengue transmission are poorly understood in Chao-Shan area, one of the most densely populated regions on China's southeastern coast, limiting disease control efforts. We aimed to characterise the epidemiology of dengue and assessed the effect of seasonal climate variation on its dynamics in the area. DESIGN: A spatio-temporal descriptive analysis was performed in three cities including Shantou, Chaozhou and Jieyang in Chao-Shan area during the period of 2014-2017. SETTING: Data of dengue cases of three cities including Shantou, Chaozhou and Jieyang in Chao-Shan area during 2014-2017 were extracted. Data for climatic variables including mean temperature, relative humidity and rainfall were also compiled. METHODOLOGY: The epidemiology and dynamics of dengue were initially depicted, and then the temporal dynamics related to climatic drivers was assessed by a wavelet analysis method. Furthermore, a generalised additive model for location, scale and shape model was performed to study the relationship between seasonal dynamics of dengue and climatic drivers. RESULTS: Among the cities, the number of notified dengue cases in Chaozhou was greatest, accounting for 78.3%. The median age for the notified cases was 43 years (IQR: 27.0-58.0 years). Two main regions located in Xixin and Chengxi streets of Chaozhou with a high risk of infection were observed, indicating that there was substantial spatial heterogeneity in intensity. We found an annual peak incidence occurred in autumn across the region, most markedly in 2015. This study reveals that periods of elevated temperatures can drive the occurrence of dengue epidemics across the region, and the risk of transmission is highest when the temperature is between 25°C and 28°C. CONCLUSION: Our study contributes to a better understanding of dengue dynamics in Chao-Shan area.

12.
Water Res ; 157: 83-93, 2019 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-30953858

RESUMO

Aerobic granular sludge (AGS) is a powerful biotechnology to remove various heavy metal(loid)s from wastewater, but not including arsenic (As). In this study, a novel manganese-oxidizing aerobic granular sludge (Mn-AGS) was developed to remove As from organic wastewater. Eight sequencing batch reactors (SBRs) were operated in duplicate to investigate the feasibility of As removal by Mn-AGS. The immobilized As in the granular sludge was characterized by sequencing extraction, X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), and Raman spectroscopy. Oxidation pathways for As and their contributions in Mn-AGS were evaluated by seven batch experiments under different conditions. The results indicated that As removal efficiency was much higher by Mn-AGS than by AGS. In Mn-AGS, As(III) was efficiently oxidized into As(V) (74.6%-82.6%) and then mostly bound on amorphous ferrihydrite and biogenic Mn oxides (bio-MnOx) (56.2%-65.0%), while metal arsenates, such as ferric arsenate, were not detected. Importantly, As removal was greatly improved by a small addition of Fe(II) in Mn-AGS. This might be primarily caused by Fenton reactions, because this improvement was removed when H2O2, self-generated in Mn-AGS, was scavenged by exogenous catalase (CAT). This study provided a novel extension of the traditional AGS technology to treat As in organic wastewater with an acceptable degree of efficiency.


Assuntos
Arsênico , Águas Residuárias , Peróxido de Hidrogênio , Manganês , Oxirredução , Esgotos
13.
World J Pediatr ; 15(3): 289-296, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30993581

RESUMO

BACKGROUND: Women who had delivered a macrosomic newborn will have a higher risk to deliver another macrosomia. We aimed to examine the recurrence risk of macrosomia in the subsequent pregnancy and the implications in long-term child health. METHODS: Data from the Collaborative Perinatal Project, a longitudinal birth cohort with 54,371 singleton births, were used. 401 recurrent macrosomic infants (macro-macro) and 1327 normal weight babies with a macrosomia in the last pregnancy (macro-normal) were selected to explore risk factors for recurrent macrosomia. Furthermore, 768 newly onset macrosomia with normal birthweight infant in previous pregnancies (normal-macro) were identified to examine long-term health effects of recurrent macrosomia. RESULTS: The recurrent rate of macrosomia was 23.2% [95% confidence interval (CI) 21.2%, 25.2%]. White race, higher pre-pregnant body mass index (BMI), more gestational weight gain, male infant and more prior macrosomic infants were significant risk factors for recurrent macrosomia. At 4 years of age, recurrent macrosomic infants had a higher BMI (16.7 vs. 16.1 kg/m2, adjusted ß: 0.36, 95% CI: 0.12, 0.60) and a higher risk of overweight and obesity (adjusted OR: 1.56, 95% CI: 1.10, 2.23) than infants with normal birthweight after a previous macrosomic sibling. There was no significant difference between recurrent macrosomia and newly onset macrosomia in child outcomes after adjustment for covariates. CONCLUSIONS: Fetal macrosomia has a high recurrence rate in the following pregnancy. Higher maternal pre-pregnant BMI and gestational weight gain are still important risk factors for recurrence of macrosomia, which in turn increases the risk for childhood obesity.


Assuntos
Macrossomia Fetal/epidemiologia , China/epidemiologia , Feminino , Humanos , Recém-Nascido , Estudos Longitudinais , Paridade , Gravidez , Fatores de Risco
14.
Molecules ; 24(8)2019 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-31013944

RESUMO

Three previously undescribed biflavonoids, oxytrodiflavanone A (1), and oxytrochalcoflavanones A,B (2,3), were isolated from the aerial part of Oxytropis chiliophylla, together with their putative biosynthetic monomers, i.e., (2S)-5,7-dihydroxyflavanone (4), (2S)-7-hydroxyflavanone (5), and 2',4'-dihydroxychalcone (6). The structures of these compounds were elucidated by a combination analysis of spectroscopic data. The cytotoxic activities of all the isolated compounds against PC-3 human prostate cancer cell line are also presented.


Assuntos
Antineoplásicos Fitogênicos , Biflavonoides , Chalconas , Flavanonas , Oxytropis/classificação , Neoplasias da Próstata/tratamento farmacológico , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/farmacologia , Biflavonoides/química , Biflavonoides/farmacologia , Chalconas/química , Chalconas/farmacologia , Flavanonas/química , Flavanonas/farmacologia , Humanos , Masculino , Células PC-3 , Neoplasias da Próstata/metabolismo , Neoplasias da Próstata/patologia
15.
BMJ Open ; 9(2): e024708, 2019 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-30772855

RESUMO

OBJECTIVE: To examine the total non-accidental mortality burden attributable to ambient temperatures and assess the effect modification of the burden by specific causes of death and individual characteristics in a high plateau area in southwest China. METHODS: Using daily mortality and meteorological data from 2009 to 2016, we applied a quasi-Poisson model combined with a distributed lag non-linear model to estimate the temperature-mortality association with the assessment of attributable fraction and number. We calculated attributable fractions and deaths with 95% empirical CIs (eCIs), that were due to cold and heat, defined as temperatures below and above the median temperature, and for mild and extreme temperatures, defined by cut-offs at the 2.5th and 97.5th temperature percentiles. RESULTS: We analysed 89 467 non-accidental deaths; 4131 were attributable to overall temperatures, with an attributable fraction of 4.75% (95% eCI 2.33% to 6.79%). Most of the mortality burden was caused by cold (4.08%; 0.86% to 7.12%), whereas the burden due to heat was low and non-significant (0.67%; -2.44% to 3.64%). Extreme cold (1.17%; 0.58% to 1.69%) was responsible for 24.6% (ie, 1.17% divided by 4.75%) of the total death burden. In the stratification analyses, attributable risk due to cold was higher for cardiovascular than respiratory disease (6.18% vs 3.50%). We found a trend of risk of increased death due to ambient temperatures with increasing age, with attributable fractions of 1.83%, 2.27% and 6.87% for age ≤64, 65-74 and ≥75 years old, respectively. The cold-related burden was slightly greater for females, farmers, ethnic minorities and non-married individuals than their corresponding categories. CONCLUSIONS: Most of the burden of death was attributable to cold, and specific causes and individual characteristics might modify the mortality burden attributable to ambient temperatures. The results may help make preventive measures to confront climate change for susceptible population in this region.

16.
Phytochemistry ; 159: 199-207, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30634082

RESUMO

Eight previously undescribed isoquinoline alkaloids, mucroniferanines H-M, together with 16 known isoquinoline alkaloids, were isolated from Corydalis mucronifera Maxim.. The structures of the previously undescribed compounds were elucidated by interpretation of 1D and 2D NMR spectroscopic and HRMS data, and their absolute configurations were established by computational electronic circular dichroism (ECD) calculations and X-ray diffraction data. Mucroniferanine L is reported as the first natural amide bond linked isoquinoline alkaloid dimer. The isolated compounds were evaluated for AChE and BuChE inhibitory activities and mucroniferanine H showed significant activities with IC50 values of 2.31 µM and 36.71 µM, respectively.


Assuntos
Acetilcolinesterase/efeitos dos fármacos , Alcaloides/farmacologia , Inibidores da Colinesterase/farmacologia , Corydalis/química , Isoquinolinas/farmacologia , Alcaloides/química , Dicroísmo Circular/métodos , Cristalografia por Raios X , Concentração Inibidora 50 , Isoquinolinas/química , Estrutura Molecular , Análise Espectral/métodos , Estereoisomerismo
17.
Bioorg Chem ; 85: 382-385, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30665032

RESUMO

Three new cytosporone derivatives dothiorelones K-M (1, 2 and 7), together with six known ones (3-6, 8 and 9) were isolated from the mangrove-derived fungus Dothiorella sp. ML002. Their structures were determined by comprehensive 1D, 2D NMR spectroscopic and HR-ESI-MS spectroscopic data. Compounds 1, 2 and 5 displayed inhibitory activities against α-glucosidase with the IC50 values of 22.0, 77.9 and 5.4 µg/mL, respectively. Additionally, compounds 1, 2, and 5 also exhibited antibacterial activities against Staphylococcus aureus (ATCC 6538) with the same MIC values of 50 µg/mL, respectively. The results indicated that cytosporone derivatives will be useful to as diabetes control agents.


Assuntos
Ascomicetos/química , Benzopiranos/farmacologia , Resorcinóis/farmacologia , Antibacterianos/isolamento & purificação , Antibacterianos/farmacologia , Antibacterianos/toxicidade , Benzopiranos/isolamento & purificação , Benzopiranos/toxicidade , Linhagem Celular Tumoral , Inibidores de Glicosídeo Hidrolases/isolamento & purificação , Inibidores de Glicosídeo Hidrolases/farmacologia , Inibidores de Glicosídeo Hidrolases/toxicidade , Humanos , Testes de Sensibilidade Microbiana , Resorcinóis/isolamento & purificação , Resorcinóis/toxicidade , Staphylococcus aureus/efeitos dos fármacos
18.
Chemosphere ; 220: 837-844, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30612053

RESUMO

Soils are experiencing increasing pollution with arsenic (As) and phthalate esters (PAEs), which is threatening human health. In this study, the feasibility of simultaneous remediation of soil As(III) and a PAE, dibutyl phthalate (DBP), by a manganese-oxidizing bacterium (MnOB) was evaluated. As immobilization and DBP degradation were simultaneously enhanced by MnOB addition. The effects of initial concentrations of As(III), DBP, and Mn(II), and moisture content on the removal of As(III) and DBP were investigated. The results indicated that there was a competitive interaction between As(III) and DBP removal, and 40 mg/kg of Mn(II) dosage and 20%-30% soil moisture content were recommended for optimal and simultaneous removal of As(III) and DBP. Microbial community analysis revealed that community structure and diversity were not changed significantly by MnOB addition. Taken together, the findings from this study indicated that DBP was degraded primarily by microorganisms, whereas As(III) was removed largely by biogenic Mn oxides and immobilized by adsorption onto Mg/Fe oxides and/or formation of metal arsenate precipitates/co-precipitates. This study offers a novel and high-efficiency strategy to remediate the combined contamination of As and PAEs in soils.


Assuntos
Arsênico/isolamento & purificação , Dibutilftalato/metabolismo , Recuperação e Remediação Ambiental/métodos , Adsorção , Arsênico/química , Bactérias/metabolismo , Humanos , Manganês/metabolismo , Compostos de Manganês/química , Óxidos/química , Solo/química , Poluentes do Solo/isolamento & purificação , Poluentes do Solo/metabolismo
19.
J Asian Nat Prod Res ; 21(6): 535-541, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29756490

RESUMO

Three new triterpenoid saponins, julibrosides A5-A7 (1-3), together with five known saponins (4-8), were isolated from the stem bark of Albizia julibrissin. Their structures were elucidated on the basis of extensive spectroscopic data analysis of MS, 1D and 2D NMR, and chemical methods. Compounds 7 and 8 were isolated from the genus Albizia for the first time. The new compounds showed no cytotoxicity and anti-inflammatory activity.


Assuntos
Albizzia/química , Saponinas/química , Triterpenos/química , Animais , Anti-Inflamatórios não Esteroides/farmacologia , Antineoplásicos Fitogênicos/farmacologia , Linhagem Celular Tumoral , Humanos , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Camundongos , Estrutura Molecular , Resultados Negativos , Óxido Nítrico/metabolismo , Casca de Planta/química , Caules de Planta/química , Saponinas/farmacologia , Triterpenos/farmacologia
20.
J Asian Nat Prod Res ; 21(4): 337-342, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29359585

RESUMO

Chemical investigation of the stem bark of Ficus tsiangii led to the isolation of a new coumarin ficuscoumarin (1) and a new norlignan ficuslignan (2) by chromatographic methods. Their structures were elucidated on the basis of spectroscopic analyses.


Assuntos
Cumarínicos/isolamento & purificação , Ficus/química , Lignanas/isolamento & purificação , Cumarínicos/química , Lignanas/química , Espectroscopia de Ressonância Magnética
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