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1.
Infect Drug Resist ; 12: 3189-3195, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31632104

RESUMO

Background: Patients with high-titer anti-IFN-γ autoantibodies present disseminated non-tuberculous mycobacterial (NTM) and other opportunistic infections. Due to its rare occurrence and non-specific symptoms, this syndrome is difficult to diagnose during early disease stages. Here, we report a case with high-concentrations of serum anti-IFN-γ autoantibodies who presented with disseminated Talaromyces marneffei and NTM disease accompanied Sweet's syndrome. Case presentation: A 62-year-old Chinese woman with no previous history was admitted to our hospital in August 2016 due to intermittent fever for 2 years, left chest wall redness, and swelling for 3 months. During hospitalization, the patient was confirmed with disseminated T. marneffei and successfully treated with antifungal therapy. In July 2017, upon second admission, Mycobacterium avium intracellular (MAC) pulmonary infection was established after positive cultures from the right lung tissue. The patient failed treatment after 1 month of anti-NTM therapy due to side effects. In May 2018, she was confirmed as having disseminated MAC disease accompanied by hand rashes, which was considered as Sweet's syndrome. High-level anti-IFN-γ antibodies in the patient serum were detected upon comparison with normal controls (2.85-fold increase). Following anti-NTM therapy, both symptoms and pulmonary infiltration gradually improved, and joint destruction and lymphadenitis remained. Conclusions: Patients with anti-interferon-γ autoantibodies should be considered for severe, recurrent infections in adults in the absence of other known risk factors. Sweet's syndrome is a common skin manifestation of the syndrome.

2.
MycoKeys ; 49: 99-129, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31043854

RESUMO

Palms represent the most morphological diverse monocotyledonous plants and support a vast array of fungi. Recent examinations of palmicolous fungi in Thailand led to the discovery of a group of morphologically similar and interesting taxa. A polyphasic approach based on morphology, multi-gene phylogenetic analyses and divergence time estimates supports the establishment of a novel pleosporalean family Striatiguttulaceae, which diversified approximately 39 (20-63) MYA (crown age) and 60 (35-91) MYA (stem age). Striatiguttulaceae is characterized by stromata or ascomata with a short to long neck, trabeculate pseudoparaphyses and fusiform to ellipsoidal, 1-3-septate ascospores, with longitudinal striations and paler end cells, surrounded by a mucilaginous sheath. Multi-gene phylogenetic analysis showed that taxa of Striatiguttulaceae form a well-supported and distinct monophyletic clade in Pleosporales, and related to Ligninsphaeriaceae and Pseudoastrosphaeriellaceae. However, these families can be morphologically demarcated by the slit-like ascomata and extremely large ascospores in Ligninsphaeriaceae and the rather narrow fusiform ascospores in Pseudoastrosphaeriellaceae. Eight strains of Striatiguttulaceae formed two monophyletic sub-clades, which can be recognized as Longicorpus gen. nov. and Striatiguttula gen. nov. Morphologically, the genus Longicorpus can be differentiated from Striatiguttula by its elongated immersed ascomata and fusiform ascospores with relatively larger middle cells and paler end cells. Two new species Striatiguttulanypae and S.phoenicis, and one new combination, Longicorpusstriataspora are introduced with morphological details, and phylogenetic relationships are discussed based on DNA sequence data.

3.
Nat Prod Res ; 33(19): 2860-2863, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30445850

RESUMO

Six compounds, benzyl 3-O-ß-D-glucopyranosyl-7-hydroxybenzoate (1), spathulenol (2), 1,7,8-trihydroxy-2-naphtaldehyde (3), quercetin (4), astragalin (5) and 2-methoxy-4-(2-propenyl)phenyl ß-D-glucoside (6), were isolated from the leaves of Melia azedarach L. The structure elucidation of compound 1 was discussed in detail based on its 2D-NMR data. Compound 1 showed weak cytotoxicity against the cell lines of T-24, NCI-H460, HepG2, SMMC-7721, CNE, MDA-MB-231 and B16F10 with the inhibition rates from 10.01% to 34.05% at the concentration of 80 µM.


Assuntos
Antineoplásicos Fitogênicos/farmacologia , Melia azedarach/química , Folhas de Planta/química , Antineoplásicos Fitogênicos/química , Antineoplásicos Fitogênicos/isolamento & purificação , Linhagem Celular , Linhagem Celular Tumoral , Ensaios de Seleção de Medicamentos Antitumorais , Glucosídeos/química , Glucosídeos/isolamento & purificação , Glucosídeos/farmacologia , Células Hep G2 , Humanos , Quempferóis/química , Quempferóis/isolamento & purificação , Quempferóis/farmacologia , Espectroscopia de Ressonância Magnética , Estrutura Molecular , Quercetina/química , Quercetina/isolamento & purificação , Quercetina/farmacologia , Sesquiterpenos/química , Sesquiterpenos/isolamento & purificação , Sesquiterpenos/farmacologia
4.
J Asian Nat Prod Res ; 21(6): 522-527, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29665732

RESUMO

A new natural product, 3α,19-dihydroxyl-ent-pimara-8(14),15-diene (1), which possesses an α-orientation hydroxymethyl at C-4 and ∆8,14 groups, as well as eight known compounds, was isolated from the rhizomes of Ricinus communis. The structure of 1 was elucidated by extensive spectroscopic methods and its absolute configurations were confirmed by X-ray crystallographic analysis. The inhibitory rate of 1 against protein tyrosine phosphatase 1B (PTP1B) was 49.49% at the concentration of 6.58 × 10-5 mol/L.


Assuntos
Diterpenos/química , Diterpenos/farmacologia , Inibidores Enzimáticos/química , Inibidores Enzimáticos/farmacologia , Proteína Tirosina Fosfatase não Receptora Tipo 1/antagonistas & inibidores , Ricinus/química , Animais , Cristalografia por Raios X , Hipoglicemiantes/química , Hipoglicemiantes/farmacologia , Camundongos , Conformação Molecular , Estrutura Molecular , Rizoma/química
5.
Zhongguo Zhong Yao Za Zhi ; 39(15): 2956-9, 2014 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-25423840

RESUMO

This study is to evaluate the effects of Shenmai injection on the temporal alterations of action potential (AP), early afterdepolarization (EAD) and delayed afterdepolarization (DAD) in papillary muscles. The action potentials were recorded by a glass electrode. APD at 90% repolarization (APD9 ) was measured, and spontaneous EAD and DAD were observed. The results show APD90 was significantly prolonged in model group compared with sham-operated group, whereas it was remained unchanged in Shenmai injec- tion treatment group and amiodarone group. The spontaneous EADs and DADs were frequently visible in model group. In conclusion, EAD, DAD and trigger activities increase gradually during pathological progression of rat cardiac hypertrophy, and Shenmai injection could improve the action potential change in rat cardiac hypertrophy.


Assuntos
Potenciais de Ação/efeitos dos fármacos , Cardiomegalia/fisiopatologia , Medicamentos de Ervas Chinesas/farmacologia , Ventrículos do Coração/efeitos dos fármacos , Ventrículos do Coração/fisiopatologia , Músculos Papilares/efeitos dos fármacos , Músculos Papilares/fisiopatologia , Animais , Pressão Sanguínea/efeitos dos fármacos , Combinação de Medicamentos , Medicamentos de Ervas Chinesas/administração & dosagem , Injeções , Masculino , Ratos , Ratos Sprague-Dawley
6.
Shanghai Kou Qiang Yi Xue ; 23(2): 237-42, 2014 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-24935852

RESUMO

PURPOSE: To evaluate the restorative effectiveness of fiber post versus metal screw post through systematical review. METHODS: Randomized controlled trials (RCTs) data from the establishment of the database up to June 2013 were searched from MEDLINE (Ovid), PubMed, The Cochrane Library, Embase, Wanfang Data, VIP, CNKI and CBM using the designed strategy. After data extraction and quality review of the retrieved articles by two independent investigators, the softwares of RevMan 5.1.0 and GRAED profiler 3.2.2 were employed to process data analysis. RESULTS: Ten RCTs were finally included, of which 1 was English literature and 9 were Chinese literatures. Meta analysis suggested that the survival rate of repair of adult and young permanent teeth was significantly higher using fiber post than metal screw post [RR=1.21,95%CI(1.13,1.30), P<0.01,RR=1.21,95%CI(1.10,1.34), P<0.01], and the results root fracture rate was significantly lower [RR=0.16,95%CI(0.05,0.48),P=0.001]. No significant difference was found in the rate of post-core fall off [RR=0.76,95%CI(0.33,1.73), P>0.05] and gingivitis [RR=0.71, 95%CI(0.27,1.88), P>0.05]. All outcomes were of low quality in the GRADE system. CONCLUSIONS: Compared with metal screw post, the survival rate is significantly higher and the root fracture rate is significantly lower by using fiber post. However, the conclusion is limited by lack of relevant studies, small sample sizes, inadequate quality and diversified methodology. Further study is needed by employing more well-designed, large-sample and multi-center RCTs to verify the conclusion.


Assuntos
Parafusos Ósseos , Coroas , Adulto , Humanos , Metais , Ensaios Clínicos Controlados Aleatórios como Assunto
7.
Guang Pu Xue Yu Guang Pu Fen Xi ; 31(9): 2508-11, 2011 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-22097859

RESUMO

In the present paper, the natural pyrite was the sample. With the UV-visible near-infrared spectrophotometer Cary 500, we measured the absorption and reflection spectra of the sample within 200-2 000 nm range, calculated the absorption coefficient and figured out the forbidden band of the sample according to the Tauc regulation. The authors discovered that the light absorption coefficient of natural pyrite measured is 10(5) order of magnitude; in the absorption pattern we found obvious shoulder line structure and we can judge that the sample belongs to indirect forbidden band semiconductor, its forbidden band was 0.64 eV in width and the "limit conversion efficiency" corresponding to 0.64 eV could reach 14% or so. With the comparison of the results of this paper and the forbidden band of the solar battery materials at present in common, this paper mainly analyzed the effect of the light absorption coefficient and forbidden band on the photoelectric conversion efficiency of pyrite. The authors found that its high absorption coefficient provided the possibility that pyrite will be used as solar battery with the film form, but its forbidden band was narrower than the theoretical number. The authors could broaden its forbidden band or make composite films to use.

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