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1.
Thyroid ; 2020 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-32031055

RESUMO

Background: Sporadic medullary thyroid carcinoma (MTC) is a relatively uncommon neuroendocrine malignancy, and the molecular tumorigenesis of its sporadic type (sMTC) is not clear enough. Here we performed a study focusing on the genomic and transcriptomic characterization of sMTC. Methods: Twenty-nine sMTC patients were included. Whole-exome sequencing (WES) was carried out in 18 patients with both tumor samples and matched noncancerous tissues. Whole transcriptome sequencing (RNA-Seq) was performed in all 29 tumors. WES, RNA-Seq and copy number alteration (CNA) data were analyzed. Cell Counting Kit-8 (CCK-8) assay was used to evaluate cell proliferation. Results: In the somatic setting, RET was the only recurrently cancer-related mutated gene (5/18, 27.8%). In the germline setting, FAT1 and FAT4, two members of the FAT gene family, were identified as the two most common mutated genes. Meanwhile, CNA analysis found that FAT1 and FAT4, both located at chromosome 4q, were also two of the most commonly affected genes by somatic chromosomal deletions (4/18, 22.2%). Using TT and MZ-CRC-1 cell lines, CCK-8 assay showed that FAT1 and FAT4 knockdown could both promote MTC cell proliferation. Based on the gene expression profile, patients were clustered into two molecular subtypes: the mesenchymal-like subtype was characterized by epithelial-mesenchymal transition, while the proliferative-like subtype was associated with enrichment of cell cycle pathways. Most events of structural recurrence (80%) occurred in the proliferative-like subtype. Conclusion: In addition to RET, our research also shows there may be high-frequency FAT1/FAT4 genomic alterations in sMTC. Two molecular subtypes of sMTC with distinct biological behaviors are also identified. However, our results need to be validated by larger samples and more comprehensive experiments in the future, especially for the frequency and function of FAT1/FAT4 germline variants.

2.
J Mol Model ; 26(2): 34, 2020 Jan 25.
Artigo em Inglês | MEDLINE | ID: mdl-31982972

RESUMO

A series of dyes are designed by adding the different electron-donating (-CH3, -NH2, -OH) and electron-withdrawing groups (-Br, -Cl, -NO2) to the different ancillary ligands in the alkynylrhenium(I) tricarbonyl diimine complexes [Re(CO)3(N^N){C≡C-C6H4-CH=C(CN)(COOH)}], where N^N = 1,10-phenanthroline (phen)(1) and then investigated the sensitization properties of dyes linked to the TiO2(101) surface. Density functional theory (DFT) and time-dependent density functional theory (TD-DFT) were used to study the electronic structure, frontier molecular orbitals, and absorption spectral properties. The effect of group-substitution on sensitization properties is obvious. When the dye molecules are combined with TiO2(101) surface, not only the absorptions of some sensitizers containing -CH3 or -OH groups have red shift but also the electrons can be directly injected into the TiO2 conduction band from the dye molecules compared with the parent molecular 1. The results indicate that the designed dyes containing electron-donating groups have smaller energy gaps, better light-harvesting efficiency, sufficient driving force, and higher charge transfer efficiency as appropriate dye sensitizers. We hope it can provide valuable hints so that we can design more efficient dye sensitizers in DSSCs.

3.
Trials ; 21(1): 102, 2020 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-31959220

RESUMO

BACKGROUND: Hysterosalpingography (HSG) is an accepted radiologic diagnostic modality for initial infertility workup, and is generally considered uncomfortable and painful. However, the management of pain related to HSG remains inefficient. As an emerging nonpharmacologic and noninvasive pain control strategy, virtual reality (VR) distraction has been successfully used in areas such as burns, blunt force trauma, hospital-based needle procedures, dental/periodontal procedures, and urological endoscopy patients. This study aims to evaluate the analgesic effect of VR during HSG. METHODS/DESIGN: A single-center, parallel-group, randomized controlled trial will be carried out in the Radiology Department of Yinchuan Women and Children Healthcare Hospital, Yinchuan. A total of 200 participants who are scheduled for HSG will be enrolled in this study. The participants will be randomized (1:1) into two groups: a VR group and a blank control group. The VR group will receive routine care plus immersive VR intervention and the blank control group will receive routine care. Outcomes will be monitored at baseline, immediately after HSG and 15 min after HSG for each group. The primary outcome is the worst pain score during HSG by a visual analog scale (VAS). The secondary outcomes include: affective pain, cognitive pain, and anxiety during the HSG procedure; worst pain within 15 min after HSG; patient satisfaction and acceptance with pain management; physiological parameters; adverse effects; HSG results; and immersion perception score of the VR system (for the VR condition only). DISCUSSION: This study will focus on exploring a simply operated, noninvasive and low-cost analgesia during the HSG procedure. The results of this trial will provide data on the feasibility and safety of VR distraction therapy during HSG. TRIAL REGISTRATION: Chinese Clinical Trial Register, ChiCTR1900021342. Registered on 16 February 2019.

4.
Bioorg Chem ; 94: 103346, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31645277

RESUMO

Many natural or synthetic chalcones have potential anti-tumor activity. Here, we synthesized two series of chalcone analogues containing a thieno[2,3-d]pyrimidin-2-yl group and evaluated for their cytotoxic activity towards cultured human lung cancer A549 and colorectal HCT-116 cells. Among them, compound 8d was the most cytotoxic against HCT-116 cells, with an IC50 value of 2.65 µM. Analyses of the phenotypic changes induced by this compound found a dose-dependent accumulation of HCT-116 cells in sub-G1 phase, indicating that compound 8d might induce apoptosis. Furthermore, we found that 8d triggered mitochondrial membrane potential depolarization, promoted reactive oxygen species formation in HCT-116 cells, and increased the percentage of early and late apoptotic cells. Finally, immunoblotting indicated that 8d increased PARP-1 and caspases 3, 7 and 9 cleavage. These data suggest that compound 8d induces apoptosis via the mitochondrial death pathway.

5.
Cancer Med ; 9(3): 1017-1024, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31854077

RESUMO

BACKGROUND: Lymph node yield (LNY) was implemented in the stratification of papillary thyroid cancer (PTC) patients. The effect of LNY may be related to the extent of surgery. This study aims to identify influencing factors for LNY in central compartment neck dissection (CND). METHODS: Data of 13 712 consecutive PTC patients were analyzed retrospectively. Risk factors for LNY in CND and distribution characteristics of LNY were evaluated. Its relationship with prognosis was studied in another cohort of 136 cases. RESULTS: LNY in therapeutic CND was significantly higher than prophylactic CND (Unilateral: 5.55 ± 3.79 vs 3.41 ± 2.77; Bilateral: 8.90 ± 5.10 vs 6.47 ± 4.17, P < .001). Other independent factors included extranodal extension (ETE), tumor size, and concurrent Hashimoto's thyroiditis. The inconsistency distribution of LNY in bilateral CND was associated with preoperative and intraoperative assessment. Patients with significant difference between major and minor LNY suffered from poorer prognosis (10y-RFS: 58.3% vs 92.0%; HR = 6.719, 95%, P < .0001). CONCLUSIONS: CND surgical procedure, ETE, and Hashimoto's thyroiditis were independent factors of LNY. Inconsistent distribution of LNY was associated with prognosis of bilateral PTC patients. The impact of preoperative and intraoperative assessment on the actual extent of CND can be used to explain the relationship between LNY and PTC prognosis.

6.
Opt Express ; 27(24): 35524-35536, 2019 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-31878722

RESUMO

We report dynamic regulation of nonlocal degree, nonlocal effects and spatial dispersion characteristics for transverse electric (TE) waves in periodic layered gyromagnetic metamaterials (PLGMs) by an applied magnetic field. A nonlocal effective permeability tensor, relying on both frequency and wave vector, is derived by expanding the accurate dispersion relation obtained by the transfer-matrix method (TMM) to high-order terms. The numerical results indicate that the degree of nonlocality of electromagnetic response in such PLGMs is closely dependent on the ratio between the period of PLGMs and the working wavelength. There are giant spatial nonlocality and strong spatial dispersion near the center or boundary of the first Brillouin zone, which leads two or three propagating modes to appear in these regions for a fixed frequency. Interestingly, the degree of nonlocality, nonlocal effects and spatial dispersion properties in such PLGMs can be manipulated dynamically by an applied static magnetic field. In addition, it is possible that a quasi-straight isofrequency contour occurs in the case of linear response. These properties make the PLGMs become excellent candidates for designing photonic devices in information communication, storage, nondiffraction transmission, and so on.

7.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 37(6): 684-686, 2019 Dec 01.
Artigo em Chinês | MEDLINE | ID: mdl-31875452

RESUMO

Double-root mandibular third molars are the common types of mandibular third molars that are prone to impac-tion. Based on the summary of clinical cases and experience, the commonly used crown-root separation technique is improved as diagonal root separation technique that divides the roots by the line connecting the distal axis angle to the root furcation. This new method improves the efficiency of the operation and reduces surgical trauma. This paper details the surgical method, minimally invasive mechanics, and key points of this technique, compares the technique with the crown-root separation tech-nique, and discusses their joint applications.


Assuntos
Dente Serotino , Dente Impactado , Humanos , Mandíbula , Dente Molar , Raiz Dentária
8.
Sheng Li Xue Bao ; 71(6): 894-904, 2019 Dec 25.
Artigo em Chinês | MEDLINE | ID: mdl-31879745

RESUMO

Ion channels are a widespread class of membrane proteins that help establish and control cell membrane potential by allowing the passive diffusion of inorganic ions with high specificity through cell membrane. They are widely distributed in various cells and tissues, and their normal structure and function are of fundamental importance for all living organisms. The rapid advances in molecular cloning, protein structure analysis, patch clamp recordings and other technologies have greatly promoted the research on the biophysical and molecular properties of ion channels, and made significant progress in the study of the relationship between ion channels and pathophysiology as well. The immune system is made up of immune cells and organs that work together to protect the body and respond to infection and disease. Remarkably, recent basic and clinical research has revealed that ion channels are frequently and abundantly expressed in immune cells and have crucial roles in immune cell development and immune response. This review summarized recent progress in the roles of ion channels in immune cells, including the expression and regulation of ion channels in immune cells, the effects of ion flux mediated by ion channels on lymphocyte development, and functional roles of ion channels in both innate and adaptive immune responses. We also discussed some unresolved and insufficiently addressed issues in the current research, so as to provide an informative reference for better understanding the functional roles of ion channels in the immune system and further elucidation of their function from a physiological and pathological point of view.


Assuntos
Imunidade , Canais Iônicos , Proteínas de Membrana , Membrana Celular , Imunidade/fisiologia , Canais Iônicos/imunologia , Pesquisa/tendências
9.
Huan Jing Ke Xue ; 40(10): 4718-4724, 2019 Oct 08.
Artigo em Chinês | MEDLINE | ID: mdl-31854843

RESUMO

In order to investigate the effects of warming and straw application on soil microbial biomass carbon and nitrogen and bacterial community structure, a randomized block experiment was performed. Four treatments were included, namely a control (CK), warming (WA), straw application (SA), and warming and straw application (WS) treatments. The soils were sampled during the soybean (Sep. 23, 2017) and winter wheat (April 21, 2018) growing seasons. The soils were used to determine the microbial biomass C and N content using chloroform fumigation methods, and the bacterial community structure was evaluated using high-throughput sequencing (Illumina HiSeq). Results indicated that there was no significant difference in microbial biomass C between different warming and straw application treatments (P>0.05). The microbial biomass N of the warming treatment was significantly higher than that of control in the soybean field (P<0.01). There were significant differences in the most dominant soil bacteria between treatments in the soybean growing season (P<0.05) at the class, order, family, and genus levels, while there was no difference in the winter wheat growing season. The percentages of dominant Gemmatimonadales, Gemmatimonadaceae, and Sphingomonas in the CK and WA (or SA) treatments were significantly different (P<0.05) in the soybean growing season. There was a significant (P<0.05) difference in the dominant Gammaproteobacteria between the CK and WA treatments in the winter wheat growing season. The observed number of species, Shannon index, Simpson index, and Chao1 index were lowest in the warming plots in the soybean growing season and highest in the warming and straw application plots in the winter wheat growing season. The Shannon index for the WA plots was significantly higher than in the WS plots in the soybean growing season (P<0.05). The observed number of species, Shannon index, Simpson index, and Chao1 index were significantly higher in the soybean plots than in the winter wheat plots (P<0.05), while the abundance was significantly higher in the winter wheat plots than in the soybean plots (P<0.05). The soybean growing season had significantly higher diversity than the winter wheat growing season. The indexes of α diversity were highly significantly correlated with soil microbial biomass C and N in the soybean growing season (P<0.001), while there was no such correlation in the winter wheat growing season. The indices of α diversity were significantly correlated in both the soybean growing season and winter wheat growing season (P<0.05).


Assuntos
Nitrogênio , Microbiologia do Solo , Solo , Agricultura , Biomassa , Carbono , Temperatura Ambiente
10.
Gland Surg ; 8(5): 557-568, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31741887

RESUMO

Background: Papillary thyroid cancer (PTC) has a strong propensity to metastasize to the cervical lymph nodes. Little was known currently about whether tumor's location would influence the risk of lymph node metastasis in PTC. Methods: The study enrolled PTC patients who underwent primary surgical therapy in our center for small unifocal tumor. The tumor's location was evaluated by ultrasound in three axes, three planes and 3D space. Logistic univariate and multivariate analysis were applied to explore the association between tumors' location and the risk of lymph node metastasis in PTC. Different localization methods of thyroid tumors were evaluated using ROC curve. Results: Totally 1,266 PTC patients were enrolled in this study. Univariate and multivariate analyses showed that gender, age, tumor size and tumor's location (in longitudinal axis, longitudinal sagittal plane, longitudinal coronal plane, sagittal coronal plane and 3D space) was associated with central lymph node dissection (CLND); gender, tumor size and tumor's location (in longitudinal axis, coronal axis, longitudinal sagittal plane, longitudinal coronal plane, sagittal coronal plane and 3D space) was related with lateral lymph node dissection (LLND) (P<0.05). In the ROC curve analysis, the 3D location showed the highest predictive value of lymph node metastasis (C-statistics: 0.724 for CLNM; 0.763 for LLNM). The middle posterior lateral (OR=2.575, P=0.028), inferior anterior central (OR=2.829, P=0.016), inferior posterior lateral (OR=2.759, P=0.039) and isthmus tumors (OR=4.526, P=0.001) were at a higher risk of CLNM, and the middle anterior central tumors (OR=0.102, P=0.015) were related with lower risk of LLNM. Conclusions: Stereotactic localization showed the highest predictive value of lymph node metastasis. The middle posterior lateral, inferior anterior central, inferior posterior lateral and isthmus tumors were at a higher risk of CLNM when compared to other locations. For such patients, careful preoperative evaluation of nodal status should be done.

11.
Diagn Interv Radiol ; 25(6): 442-450, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31650970

RESUMO

PURPOSE: We aimed to evaluate the quality of chest computed tomography (CT) images obtained with low-dose CT using three iterative reconstruction (IR) algorithms. METHODS: Two 64-detector spiral CT scanners (HDCT and iCT) were used to scan a chest phantom containing 6 ground-glass nodules (GGNs) at 11 radiation dose levels. CT images were reconstructed by filtered back projection or three IR algorithms. Reconstructed images were analyzed for CT values, average noise, contrast-to-noise ratio (CNR) values, subjective image noise, and diagnostic acceptability of the GGNs. Repeated-measures analysis of variance was used for statistical analyses. RESULTS: Average noise decreased and CNR increased with increasing radiation dose when the same reconstruction algorithm was applied. Average image noise was significantly lower when reconstructed with MBIR than with iDOSE4 at the same low radiation doses. The two radiologists showed good interobserver consistency in image quality with kappa 0.83. A significant relationship was found between image noise and diagnostic acceptability of the GGNs. CONCLUSION: Three IR algorithms are able to reduce the image noise and improve the image quality of low-dose CT. In the same radiation dose, the low-dose CT image quality reconstructed with MBIR algorithms is better than that of other IR algorithms.

12.
Front Microbiol ; 10: 2135, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31572340

RESUMO

Tuberculosis is still a major threat to global public health. Here, a novel diagnosis assay, termed as multiple cross displacement amplification combined with nanoparticle-based lateral flow biosensor (MCDA-LFB), was developed to simultaneously detect IS6110 and IS1081 of Mycobacterium tuberculosis (MTB) in DNA extracted from reference strain H37Rv and clinical samples. The amplification can be finished within 30 min at a fixed temperature (67°C), thus the whole procedure, including rapid template preparation (15 min), isothermal reaction (30 min) and result reporting (2 min), can be completed within 50 min. The limit of detection of multiplex MCDA assay was 10 fg per reaction. By using the multiplex MCDA protocol, cross-reaction with non-mycobacteria and non-tuberculous mycobacteria (NTM) strains was not observed. Among clinically diagnosed TB patients, the sensitivity of liquid culture, Xpert MTB/RIF and multiplex MCDA assay was 42.0% (50/119), 49.6% (59/119), and 88.2% (105/119), respectively. Among culture positive samples, the sensitivity of Xpert MTB/RIF and multiplex MCDA assay was 86.0% (43/50) and 98.0% (49/50), respectively. Among culture negative samples, the sensitivity of Xpert MTB/RIF and multiplex MCDA assay was 23.2% (16/69) and 81.2% (56/69), respectively. The specificity was 100% (60/60) for Xpert MTB/RIF and 98.3% (59/60) for multiplex MCDA. Therefore, the multiplex MCDA assay for MTB detection is rapid, sensitive and easy to use and may be a promising test for early diagnosis of TB.

13.
Neuroendocrinology ; 2019 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-31655821

RESUMO

BACKGROUND: Neuroendocrine tumor (NET) rarely occurs in the mediastinum and the etiology and pathogenesis are still unclear. OBJECTIVES: This study assessed inherited or de novo mutations in familial mediastinal NETs. METHOD: DNA samples from four persons were subjected to the whole-exome sequencing, and Sanger sequencing was used to identify Deleted in malignant brain tumor 1 (DMBT1) mutations in all 45 family members. RESULTS: All patients showed a germline DMBT1 mutation at 4971C. Sanger sequencing data showed that four NETs and two carriers in the first patient family had this DMBT1 mutation, and two NETs and four carriers in the second patient family had this DMBT1 mutation. The in vitro data showed that ectopic expression of DMBT1 reduced tumor cell viability and migration by arresting the G1/S phase of cell cycle. CONCLUSIONS: The data from current study identified a germline missense mutation in DMBT1D1657E as a susceptibility gene for familial mediastinal NETs.

14.
J Emerg Med ; 57(4): 444-452, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31514988

RESUMO

BACKGROUND: Acute pain is the most common complaint in Emergency Department (ED) admissions, and options for analgesia are limited. Nitrous oxide/oxygen possesses many properties showing it may be an ideal analgesic in the ED. OBJECTIVES: The aim of this study is to evaluate the safety and analgesic effect of the fixed nitrous oxide/oxygen mixture for trauma patients in the ED. METHODS: We enrolled 60 patients in this double-blind, randomized study. The treatment group received conventional pain treatment plus a mixture of 65% nitrous oxide/oxygen. The control group received the conventional pain treatment plus oxygen. Primary outcome was the reduction in pain intensity at 5 and 15 min after the start of intervention. Secondary outcomes include adverse events, physiological parameters, and satisfaction from both patients and health care professionals. RESULTS: Initial pain scores for the nitrous oxide/oxygen group (6.0 [5.0-8.0]) and the oxygen group (6.75 [5.0-9.0]) were comparable (p = 0.57). The mean numerical rating scale scores at 5 min were 3.4 ± 1.8 and 7.0 ± 1.8 for nitrous oxide/oxygen and oxygen, respectively (p < 0.01). The mean pain intensity at 15 min in the treatment group was 3.0 ± 1.9, compared with 6.3 ± 2.2 in the control group (p < 0.01). Both patients' (8.0 [7.0-9.0] vs. 4.0 [2.0-6.0], p < 0.01) and physicians' (8.5 [8.0-9.0] vs. 4.0 [3.0-6.0], p < 0.01) satisfaction scores in the treatment group were significantly higher than the oxygen group. No serious adverse events were observed. CONCLUSIONS: This study gives supporting evidence for the safety and effectiveness of using self-administered nitrous oxide/oxygen mixture in the ED for moderate-to-severe traumatic pain.

15.
BMC Vet Res ; 15(1): 294, 2019 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-31412870

RESUMO

BACKGROUND: Glaesserella parasuis (G. parasuis) is an influential pathogen of the pig, which induces high morbidity and mortality in naive pig populations in the pig industry. Accurate and rapid detection of the agent is important for disease control. In this study, a simple recombinase polymerase amplification (RPA) with a Lateral flow (LF) strip (RPA-LF-GPS) was developed to detect G. parasuis. RESULTS: The RPA-LF-GPS can specifically detect G. parasuis a limit of 100 CFU from other common related pathogens causing arthritis in the pig. The RPA-LF-GPS assay can use boiled synovial fluid samples as a template with the same sensitivity as other DNA extraction methods. In the detection of clinic positive synovial fluid sample, RPA-LF-GPS is equally sensitive (98.1%) compared with that of PCR (90.4%) (P > 0.05). The whole procedure of the RPA-LF-GPS assay could be finished in 1 hour without professional equipment. CONCLUSIONS: RPA-LF-GPS assay is a rapid and simple method for point-of-care diagnostic testing for G. parasuis infection.


Assuntos
Infecções por Haemophilus/veterinária , Haemophilus parasuis , Recombinases/metabolismo , Doenças dos Suínos/microbiologia , Líquido Sinovial/microbiologia , Animais , Infecções por Haemophilus/microbiologia , Técnicas de Amplificação de Ácido Nucleico/veterinária , Reação em Cadeia da Polimerase/veterinária , Recombinases/química , Recombinases/genética , Sensibilidade e Especificidade , Suínos , Doenças dos Suínos/diagnóstico
16.
J Cancer ; 10(18): 4380-4388, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31413758

RESUMO

Background: The aim of this study was to develop and validate prognostic nomograms predicting overall (OS) and cancer-specific survival (CSS) of patients with major salivary gland (MaSG) mucoepidermoid carcinoma (MEC). Methods: 1398 MaSG-MEC patients were identified from the Surveillance, Epidemiology and End Results (SEER) database. They were randomly and equally divided into a training cohort (n=699) and a validation cohort (n=699). The best subsets of covariates were identified to develop nomograms predicting OS and CSS based on the smallest Akaike Information Criterion (AIC) value in the multivariate Cox models. The nomograms were internally and externally validated by the bootstrap resampling method. The predictive ability was evaluated by Harrell's Concordance Index (C-index). Results: For the training cohort, eight (age at diagnosis, tumor grade, primary site, surgery, radiation, T, N and M classification) and seven predictors (all the above factors except primary site) were selected to create the nomograms estimating the 3- and 5- year OS and CSS, respectively. C-index indicated better predictive performance of the nomograms than the 7th AJCC staging system, which was confirmed by both internal (via the training cohort: OS: 0.888 vs 0.785, CSS: 0.938 vs 0.821) and external validation (via the validation cohort: OS: 0.844 vs 0.743, CSS: 0.882 vs 0.787). The calibration plots also revealed good agreements between the nomogram-based prediction and observed survival. Conclusions: We have proposed and validated the nomograms predicting OS and CSS of MaSG-MEC. They are proved to be of higher predictive value than the AJCC staging system and may be adopted in future clinical practice.

17.
ACS Appl Mater Interfaces ; 11(36): 33091-33101, 2019 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-31414794

RESUMO

Transition metal carbonates/hydroxides have attracted much attention as appealing anode materials due to their considerable reversible electrochemical catalytic conversion capacity. However, their serious positive or negative trends with cycles caused by the electrochemical catalytic conversion seriously affect their practical applications. Herein, novel one-dimensional cobalt hydroxide carbonate (CHC) nanomaterials are tightly anchored on reduced graphene oxide (RGO) sheets via a facile one-pot hydrothermal synthesis, forming surface-confined domains to further restrict the electrochemical catalytic conversion process. The analysis on the cycled electrodes at varied potentials confirms that the added capacity of CHC arises from the step-by-step reversible reactions of Li2CO3 and LiOH under the electrochemical catalysis of Co metal generated by the conversion reaction of CHC. The reversible reaction of Li2CO3 is followed closely by that of LiOH in the discharge process, while the order is opposite in the charge process. Such a step-by-step electrochemical catalytic conversion process could confine each other to accommodate the volume change and avoid side reactions. The confined effect is further enhanced by limiting the width and length of the CHC, which are determined by regulating the nucleation and growth of CHC on the surface of RGO, leading to an extraordinary cyclability. The optimized CHC/RGO hybrid maintains a high reversible capacity of 1110 mA h g-1 after 100 cycles at 0.1 A g-1, which is much higher than the theoretical value of CHC (506 mA h g-1) on the basis of the recognized conversion reaction. Furthermore, it keeps high reversible capacities of 755 and 506 mA h g-1 after 200 cycles at 1 and 2 A g-1, respectively, exhibiting a high-rate cyclability with the lowest coefficient of variance of 9.4% among the reported ones. The confined step-by-step electrochemical catalytic conversion process facilitates high lithium storage capacity and satisfactory cyclability with a pretty low variance coefficient.

18.
Nat Prod Res ; : 1-7, 2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31460795

RESUMO

Two new dihydroisocoumarins (1 and 2), together with six known compounds (3-8), were isolated from the fungus Penicillium sp. XR046 collected from the Xinren coal area of Guizhou province in China. Their structures were elucidated on the basis of spectroscopic analysis. The absolute configurations of C-3 in 1 and 2 were established by comparison of their CD data with those of known compounds. Compounds 1-6 showed anti-microbial activities with MIC values in the range of 50∼100 µg/mL against Candida albicans, Staphylococcus epidermidis, Bacillus subtilis, and Escherichia coli.

19.
Br J Radiol ; 92(1103): 20190461, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31430199

RESUMO

OBJECTIVE: Main duct and mixed intraductal papillary mucinous neoplasms (IPMN) are pre-malignant cystic pancreatic neoplasms associated with pancreatic duct dilatation. Distinguishing these from benign causes of pancreatic duct dilatation is important in order to allow appropriate surveillance or surgery. A patulous duodenal papilla with extrusion of mucus at endoscopic evaluation, the endoscopic fish mouth ampulla (E-FMA) sign, is reported in main duct and mixed IPMN. We aimed to establish whether a CT correlate (CT-FMA) of this sign exists and whether this was associated with the presence of invasion or high-grade dysplasia. We defined the CT-FMA sign as an uninterrupted column of water attenuation material running from the pancreatic duct to the duodenal lumen. METHODS: A retrospective, blinded review of 44 patients with histologically confirmed IPMN and 87 age-matched controls with pancreatic duct dilatation on CT was undertaken. A case-control series matched for the degree of pancreatic duct dilatation was used to compare the rates of invasion or high-grade dysplasia between main duct and mixed IPMN patients, with and without a CT-FMA sign. RESULTS: The CT-FMA sign could be identified in 18.5% patients with main duct/mixed IPMN with specificity 100%, positive predictive value 100% and negative predictive value 79.8%. A significant association was found between CT-FMA in main duct/mixed IPMN compared to controls, but not with the presence of high-grade dysplasia or invasion. CONCLUSIONS: The CT-FMA sign is a newly reported, highly specific sign of MD and mixed IPMN. ADVANCES IN KNOWLEDGE: If a fish mouth ampulla is identified at CT, a diagnosis of main duct or mixed IPMN is highly likely.


Assuntos
Adenocarcinoma Mucinoso/diagnóstico por imagem , Carcinoma Ductal Pancreático/diagnóstico por imagem , Neoplasias Pancreáticas/diagnóstico por imagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Ampola Hepatopancreática/diagnóstico por imagem , Estudos de Casos e Controles , Humanos , Pessoa de Meia-Idade , Lesões Pré-Cancerosas/diagnóstico por imagem , Estudos Retrospectivos , Tomografia Computadorizada por Raios X
20.
Oncol Lett ; 18(2): 1579-1584, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31423225

RESUMO

Warburg found that tumor cells exhibit high-level glycolysis, even under aerobic condition, which is known as the 'Warburg effect'. As systemic changes in the entire metabolic network are gradually revealed, it is recognized that metabolic reprogramming has gone far beyond the imagination of Warburg. Metabolic reprogramming involves an active change in cancer cells to adapt to their biological characteristics. Thyroid cancer is a common endocrine malignant tumor whose metabolic characteristics have been studied in recent years. Some drugs targeting tumor metabolism are under clinical trial. This article reviews the metabolic changes and mechanisms in thyroid cancer, aiming to find metabolic-related molecules that could be potential markers to predict prognosis and metabolic pathways, or could serve as therapeutic targets. Our review indicates that knowledge in metabolic alteration has potential contributions in the diagnosis, treatment and prognostic evaluation of thyroid cancer, but further studies are needed for verification as well.

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