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1.
Food Chem ; 335: 127653, 2021 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-32739818

RESUMO

Buckwheat is a gluten-free crop under the family Polygonaceae abundant with beneficial phytochemicals that provide significant health benefits. It is cultivated and adapted in diverse ecological zones all over the world. Recently its popularity is expanding as a nutrient-rich healthy food with low-calories. The bioactive compounds in buckwheat are flavonoids (i.e., rutin, quercetin, orientin, isoorientin, vitexin, and isovitexin), fatty acids, polysaccharides, proteins, and amino acids, iminosugars, dietary fiber, fagopyrins, resistant starch, vitamins, and minerals. Buckwheat possesses high nutritional value due to these bioactive compounds. Additionally, several essential bioactive factors that have long been gaining interest because these compounds are beneficial for healing and preventing several human diseases. The present review demonstrates an overview of the recent researches regarding buckwheat phytochemicals and particularly focusing on the distinct function of bioactive components with their health benefits.

2.
Artigo em Inglês | MEDLINE | ID: mdl-32998819

RESUMO

INTRODUCTION: Preeclampsia (PE) is associated with an exaggerated maternal systemic inflammatory response. Throughout gestation, the placenta releases extracellular vesicles through the syncytiotrophoblast layer (STB) into the maternal circulation and this is increased in PE. Expression of Siglec-6, a transmembrane receptor of molecular weight 50 KDa, is upregulated in PE placental tissue. METHODS: Here we investigated respective abundance of Siglec-6 in PE -and normal pregnancy- (NP) derived placental lysates (PL) and syncytiotrophoblast-derived extracellular vesicles (STBEV). STBEV from PE and NP placentas were isolated through dual-lobe placental perfusion and serial ultracentrifugation. Siglec-6 was characterized by immunohistochemistry, immunoblotting, mass spectrometry (MS), and deglycosylation. RESULTS: Immunoblotting revealed the expected Siglec-6 (50 KDa) band present in both PE and NP PL, however an additional heavier band was observed at 70 KDa only in PE PL, but not in NP. When interrogating STBEV we saw an absence of the expected 50 KDa band but the 70 KDa was present predominantly only in the PE STBEV. Deglycosylation of PL and STBEV from PE showed that the 70 KDa and the 50 KDa bands were reduced to 48 KDa, suggesting glycosylation. Both 48 KDa and 70 KDa bands were subjected to MS, confirming Siglec-6 expression in both. DISCUSSION: Our data shows that the inability to detect Siglec-6 in circulation might be due to the placenta secreting STBEV carrying a modified glycosylated form of Siglec-6 with a 70 KDa molecular weight, significantly and uniquely upregulated in PE STBEV.

3.
Macromol Rapid Commun ; : e2000438, 2020 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-33000900

RESUMO

The primary issue of polymer electrolytes is to achieve high ion conductivity while retaining mechanical properties. A nanocomposite electrolyte with the inverse hexagonal cylindrical phase (three-dimensionally continuous domains for ion conduction and embedded domains for mechanical support) is prepared through the electrostatic self-assembly of a polyoxometalate (H3 PW12 O40 , PW) and a triblock copolymer poly(N-vinyl pyrrolidone)-block-polystyrene-block-poly(N-vinyl pyrrolidone) (PSP). The cylindrical nanocomposite exhibits a conductivity of 1.32 mS cm-1 and a storage modulus of 4.6 × 107  Pa at room temperature. These two values are higher than those of pristine PSP by two orders of magnitudes and a factor of six, respectively. PW clusters are used as multifunctional nano-additives (morphological inducer, proton conductor, and nano-enhancer) and their incorporation achieves the simultaneous improvement in both conductive and mechanical performance.

4.
Artigo em Inglês | MEDLINE | ID: mdl-33001393

RESUMO

Soil pollution is one of the most important issues in environmental governance at present. Using scientific and reasonable methods to estimate the economic losses caused by soil pollution is the basis for maximizing the effectiveness of governance resources. This study combines the methods of mixed group discussion and literature analysis to establish preliminary soil pollution value loss measurement indicators. The Delphi method is used to modify, add, and delete indicators to obtain a set of feasible soil pollution value loss measurement indicator systems. It laid a method foundation for further quantifying the loss of soil pollution value and provided support to related government decisions such as land resource management and soil pollution control. The response coefficients of the two rounds of expert consultations were 81.2% and 77.8%; the degree of expert authority was 0.647 and 0.708; the coordination coefficients were 0.155 and 0.194; the final indicator system included three dimensions of economic, social, and environmental, a total of eight indicators. The experts in the soil pollution value loss measurement index system established in this study have unified final opinions and a good degree of coordination, which can be used to measure soil pollution value loss.

5.
J Am Chem Soc ; 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33002358

RESUMO

Hybrid organic-inorganic perovskites (HOIPs) with the general formula ABX3 hold phenomenal research interest for their great scientific and technological potential in photovoltaic, piezoelectric, and electroluminescent devices. It is their considerable structural diversity that offers a good opportunity to build a variety of HOIP structures with various functionalities. However, no organometallic-based HOIP piezoelectrics have yet been found, despite the structural diversity and functional richness of organometallic compounds such as the ferrocene-based family. Here, for the first time, we report an organometallic-based HOIP piezoelectric, [(ferrocenylmethyl)trimethylammonium]PbI3. Benefitting from the stability of ferrocene-based cations, excellent piezoelectric performance, comparable to that of LiNbO3, can be obtained and optimized by tuning the anionic framework. The involvement of organometallic cations enables a narrow band gap of 2.37 eV, much lower than those of most HOIPs and some inorganic semiconductors. This work provides a new future direction for the study of perovskites and will inspire intriguing research on organometallic-based HOIP piezoelectrics.

6.
Diabetes Ther ; 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33006131

RESUMO

INTRODUCTION: To evaluate whether the extent of gastrectomy or the reconstruction method brings benefit of type 2 diabetes mellitus (T2DM) remission after gastrectomy in patients with gastric cancer. METHODS: PUBMED, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library were searched to find eligible studies published from inception to July 31, 2020. RESULTS: A total of nine studies (1424 patients) were included. At the first year and the end of follow-up time after gastrectomy, the total gastrectomy group had better T2DM remission than the subtotal gastrectomy group, and the Roux-en-Y reconstruction (R-Y) group had better T2DM remission compared with the non-R-Y group. There was no difference between R-Y and non-R-Y in terms of subtotal gastrectomy (OR 1.08, 95% CI 0.63-1.84, P = 0.78). However, total gastrectomy with R-Y had better T2DM remission than subtotal gastrectomy with R-Y (OR 2.75, 95% CI 1.19-6.35, P = 0.02). CONCLUSION: Total gastrectomy with R-Y had better T2DM remission. The extent of gastrectomy rather than the reconstruction method might play an important role in T2DM remission after gastrectomy in patients with gastric cancer.

8.
Sci Rep ; 10(1): 16712, 2020 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-33009495

RESUMO

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

9.
Sci Rep ; 10(1): 16218, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33004830

RESUMO

The Notch signaling network determines stemness in various tissues and targeting signaling activity in malignant brain cancers by gamma-secretase inhibitors (GSI) has shown promising preclinical success. However, the clinical translation remains challenging due to severe toxicity side effects and emergence of therapy resistance. Better anti-Notch directed therapies, specifically directed against the tumor promoting Notch receptor 1 signaling framework, and biomarkers predicting response to such therapy are of highest clinical need. We assessed multiple patient datasets to probe the clinical relevance Notch1 activation and possible differential distribution amongst molecular subtypes in brain cancers. We functionally assessed the biological effects of the first-in-human tested blocking antibody against Notch1 receptor (brontictuzumab, BRON) in a collection of glioma stem-like cell (GSC) models and compared its effects to genetic Notch1 inhibition as well as classical pharmacological Notch inhibitor treatment using gamma-secretase inhibitor MRK003. We also assess effects on Wingless (WNT) stem cell signaling activation, which includes the interrogation of genetic WNT inhibition models. Our computed transcriptional Notch pathway activation score is upregulated in neural stem cells, as compared to astrocytes; as well as in GSCs, as compared to differentiated glioblastoma cells. Moreover, the Notch signature is clinical predictive in our glioblastoma patient discovery and validation cohort. Notch signature is significantly increased in tumors with mutant IDH1 genome and tumors without 1p and 19q co-deletion. In GSCs with elevated Notch1 expression, BRON treatment blocks transcription of Notch pathway target genes Hes1/Hey1, significantly reduced the amount of cleaved Notch1 receptor protein and caused significantly impairment of cellular invasion. Benchmarking this phenotype to those observed with genetic Notch1 inhibition in corresponding cell models did result in higher reduction of cell invasion under chemotherapy. BRON treatment caused signs of upregulation of Wingless (WNT) stem cell signaling activity, and vice versa, blockage of WNT signaling caused induction of Notch target gene expression in our models. We extend the list of evidences that elevated Notch signal expression is a biomarker signature declaring stem cell prevalence and useful for predicting negative clinical course in glioblastoma. By using functional assays, we validated a first in man tested Notch1 receptor specific antibody as a promising drug candidate in the context of neuro oncology and propose biomarker panel to predict resistance and therapy success of this treatment option. We note that the observed phenotype seems only in part due to Notch1 blockage and the drug candidate leads to activation of off target signals. Further studies addressing a possible emergence of therapy resistance due to WNT activation need to be conducted. We further validated our 3D disease modeling technology to be of benefit for drug development projects.

10.
J Mater Chem B ; 2020 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-33026041

RESUMO

Dihydroartemisinin (DHA) has been regarded as a potential anticancer agent in recent years. Nevertheless, the clinical applications of DHA are seriously restricted as a result of its intrinsic characteristics, such as poor water solubility, instability, and fast clearance. Herein, a type of fluorescent nanoparticles was successfully fabricated via supramolecular assembling of carbon dots (CDs) and DHA. The formulated CDs-DHA fluorescent nanoparticles not only significantly improve the solubility and stability of DHA, but also possess favorable biocompatibility and pH-dependent drug release behavior. In particular, the hybrids of CDs and DHA as nanocarriers can effectively promote the endocytosis of DHA and exhibit enhanced antitumor effects compared with free DHA in vitro and in vivo. In addition, we also explore the possible action mechanism of CDs-DHA through flow cytometric assay, transfection and western blot analysis. The results indicate that CDs-DHA nanoparticles suppress the progression of hepatic carcinoma through inducing apoptosis and inhibiting glucose metabolism, and the mechanism is related to the downregulation of PKM2 expression and the suppression of the Akt/mTOR signaling pathway, which may provide a potential therapeutic target for hepatic carcinoma treatment. This work emphasizes the great potential of utilizing CDs as a safe and convenient platform to deliver DHA for efficient cancer therapy, and the study on the anticancer mechanism can also offer theoretical support for the clinical application of DHA.

11.
Artigo em Inglês | MEDLINE | ID: mdl-33011212

RESUMO

PURPOSE: Currently, there are about 15 ongoing clinical studies on low dose radiotherapy (LDRT) for COVID-19 pneumonia. One of the underlying assumptions is that irradiation of 0.5-1.5 Gy is effective at ameliorating viral pneumonia. We aimed to reanalyze all available experimental radiobiological data to assess evidence for such amelioration. METHODS AND MATERIALS: With standard statistical survival models, and based on a systematic literature review, we re-analyzed thirteen radiobiological animal datasets published in 1937-1973 in which animals (guinea pigs/dogs/cats/rats/mice) received radiation before or after bacterial/viral inoculation, and assessing various health endpoints (mortality/pneumonia morbidity). In most datasets absorbed doses did not exceed 7 Gy. RESULTS: For six studies evaluating post-inoculation radiation exposure (more relevant to LDRT for COVID-19 pneumonia) the results are heterogeneous, with one study showing a significant increase (p<0.001) and another showing a significant decrease (p<0.001) in mortality associated with radiation exposure. Among the remaining four studies, mortality risk was non-significantly increased in two studies and non-significantly decreased in two others (p>0.05). For pre-inoculation exposure the results are also heterogeneous, with six (of eight) datasets showing a significant increase (p<0.01) in mortality risk associated with radiation exposure and the other two showing a significant decrease (p<0.05) in mortality or pneumonitis morbidity risk. CONCLUSIONS: These data do not provide support for reductions in morbidity or mortality associated with post-infection radiation exposure. For pre-infection radiation exposure the inconsistency of direction of effect is difficult to interpret. One must be cautious about adducing evidence from such published reports of old animal datasets.

12.
Artigo em Inglês | MEDLINE | ID: mdl-33017186

RESUMO

Sepsis-induced acute kidney injury (SA-AKI) is associated with high mortality rates, but clinicians lack effective treatments except supportive care or renal replacement therapies. Recently, histone deacetylase (HDAC) inhibitors have been recognized as potential treatments for AKI and sepsis in animal models; however, the adverse effect generated by use of pan-inhibitors of HDACs may limit their application in people. In this study, we explored the possible renoprotective effect of a selective class IIa HDAC inhibitor TMP195 in a murine model of SA-AKI induced by lipopolysaccharide (LPS). Administration of TMP195 significantly reduced increased serum creatinine and blood urea nitrogen levels and renal damage induced by LPS; this was coincident with reduced expression of HDAC4, a major isoform of class IIa HDACs, and elevated histone H3 acetylation. TMP195 treatment following LPS exposure also reduced renal tubular cell apoptosis and attenuated renal expression of NGAL and Kim-1, two biomarkers of tubular injury. Moreover, LPS exposure resulted in increased expression of BAX and cleaved caspase3, and decreased expression of BCL-2 and BMP-7 in vivo and in vitro; TMP195 treatment reversed these responses. Finally, TMP195 inhibited LPS-induced upregulation of multiple proinflammatory cytokines/chemokines, including ICAM-1, MCP-1, TNF-α, and IL-1ß and accumulation of inflammatory cells in the injured kidney. Collectively, these data indicated that TMP195 has a powerful renoprotective effect in SA-AKI by mitigating renal tubular cell apoptosis and inflammation, and suggest that targeting class IIa HDACs might be a novel therapeutic strategy for the treatment of SA-AKI that avoids the unintended adverse effects of a pan-HDAC inhibitor.

13.
ChemSusChem ; 2020 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-33017513

RESUMO

The carboxylation of cyclic oxime esters with carbon dioxide via visible-light photoredox catalysis is demonstrated for the first time. A variety of cyclopentanone and cyclobutanone oxime esters undergo ring-opening C-C bond cleavage and carboxylation to give cyanoalkyl-containing carboxylic acids in moderate to good yields. Moreover, this methodology features mild reaction conditions (room temperature, 1 atm), wide substrate scope, good functional group tolerance as well as facile derivations of products. Mechanistic studies indicate that the benzylic radicals and anions might be the key intermediates.

14.
J Clin Pathol ; 2020 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-33020176

RESUMO

AIMS: A growing research demonstrated that YAP1 played important roles in gliomagenesis. We explored the expression of YAP1 and STAT3, the relationship between them and the effect of YAP1, STAT3 on prognosis in glioma. METHODS: Expression of YAP1, p-YAP1, STAT3, pSTAT3-S727 and pSTAT3-Y705 in 141 cases of low-grade gliomas (LGG) and 74 cases of high-grade gliomas (HGG) of surgical specimens were measured by immunohistochemistry. Pearson's X2 test was used to determine the correlation between immunohistochemical expressions and clinicopathological parameters. Pearson's or Spearman correlation test was used to determine the association between these proteins expression. Survival analysis was used to investigate the effect of these proteins on prognosis. RESULTS: High expressions of YAP1, STAT3, pSTAT3-S727 and pSTAT3-Y705 were found in HGG compared with LGG (p=0.000). High expressions of YAP1, STAT3, pSTAT3-S727 and pSTAT3-Y705 were found in 63.5%, 59.5%, 66.2% and 31.1% cases of HGG, respectively. YAP1 expression was associated to tumour location, Ki-67 and P53, STAT3 expression was related with Ki-67 and P53, and the expression of pSTAT3-S727 was associated with Ki-67. There was a significantly positive correlation between YAP1 and pSTAT3-S727 (p<0.0001; r=0.5663). Survival analysis revealed that patients with YAP1 and pSTAT3-S727 coexpression had worse overall survival (OS) and progression-free survival (PFS) (p<0.0001). Tumour grade, age, Ki-67 and YAP1 expression were independent prognostic factors for OS. In LGG group, both YAP1 and pSTAT3-S727 expressions were negative correlation with IDH1 mutation, YAP1 and pSTAT3-S727 coexpression showed worse OS and PFS of glioma patients. CONCLUSION: Our research showed that YAP1 and STAT3 were significantly activated in HGG compared with LGG. YAP1 significantly correlated with pSTAT3-S727 in glioma, YAP1 and pSTAT3-S727 coexpression may serve as a reliable prognostic biomarker and therapeutic target for glioma.

15.
Artigo em Inglês | MEDLINE | ID: mdl-33015978

RESUMO

The protective functions of thalidomide in paraquat (PQ)-induced injury have been reported. But the mechanisms remain largely unknown. In this research, a PQ-treated rat model was established and further treated with thalidomide. Oedema and pathological changes, oxidative stress, inflammation, fibrosis, and cell apoptosis in rat lungs were detected. A PQ-treated RLE-6TN cell model was constructed, and the viability and apoptosis rate of cells were measured. Differentially expressed microRNAs (miRNAs) after thalidomide administration were screened out. Binding relationship between miR-141 and histone deacetylase 6 (HDAC6) was validated. Altered expression of miR-141 and HDAC6 was introduced to identify their functions in thalidomide-mediated events. Consequently, thalidomide administration alone exerted no damage to rat lungs; in addition it reduced PQ-induced oedema. The oxidative stress, inflammation and cell apoptosis in rat lungs were reduced by thalidomide. In RLE-6TN cells, thalidomide increased cell viability and decreased apoptosis. miR-141 was responsible for thalidomide-mediated protective events by targeting HDAC6. Overexpression of HDAC6 blocked the protection of thalidomide against PQ-induced injury via activating the IkBα-NF-κB signalling pathway. Collectively, this study evidenced that thalidomide protects lung tissues from PQ-induced injury through a miR-141/HDAC6/IkBα-NF-κB axis.

16.
J Clin Invest ; 2020 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-33016929

RESUMO

ARID1A, a component of the chromatin-remodeling complex SWI/SNF, is one of the most frequently mutated genes in human cancer. We sought to develop rational combination therapy to potentiate the efficacy of immune checkpoint blockade in ARID1A-deficient tumors. In a proteomic analysis of a data set from The Cancer Genomic Atlas, we found enhanced expression of Chk2, a DNA damage checkpoint kinase, in ARID1A-mutated/deficient tumors. Surprisingly, we found that ARID1A targets the nonchromatin substrate Chk2 for ubiquitination. Loss of ARID1A increased the Chk2 level through modulating autoubiquitination of the E3-ligase RNF8 and thereby reducing RNF8-mediated Chk2 degradation. Inhibition of the ATM/Chk2 DNA damage checkpoint axis led to replication stress and accumulation of cytosolic DNA, which subsequently activated the DNA sensor STING-mediated innate immune response in ARID1A-deficient tumors. As expected, tumors with mutation or low expression of both ARID1A and ATM/Chk2 exhibited increased tumor-infiltrating lymphocytes and were associated with longer patient survival. Notably, an ATM inhibitor selectively potentiated the efficacy of immune checkpoint blockade in ARID1A-depleted tumors but not in WT tumors. Together, these results suggest that ARID1A's targeting of the nonchromatin substrate Chk2 for ubiquitination makes it possible to selectively modulate cancer cell-intrinsic innate immunity to enhance the antitumor activity of immune checkpoint blockade.

17.
Biochim Biophys Acta Rev Cancer ; : 188443, 2020 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-33035642

RESUMO

Fibroblasts have gained increasing attention in tissue desmoplasia, especially in tumors. Activated fibroblasts from various sources modulate matrix composition and stiffness associated with organ fibrosis as well as tumor progression. More importantly, cancer-associated fibroblasts (CAFs) interacts with both cancer cells and other stromal cells, providing a tumor-promoting microenvironment for tumor invasion and metastasis. However, CAF biology is not fully understood due to its heterogeneity. Here, we describe the main transforming cues that contribute to CAF activation and unveil the expanding CAF heterogeneity associated with tumor progression in multiple aspects. Finally, we summarize the prospective promising and challenging stroma-targeted anti-tumor strategies.

18.
Animals (Basel) ; 10(10)2020 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-33036300

RESUMO

Wildlife conservation and management has become a very complex public policy issue in China as concerns over on animal welfare and empathy for animals have grown. Science-based conservation strategies that are oriented toward sustainable wildlife management (SWM) are under threat as these new attitudes and values emerge and take hold. This study accesses the attitudes of college students towards SWM and wildlife conservation, and investigates demographic characteristics influencing their attitudes in China, a country that is traditionally associated with consumptive use of wildlife and SWM, but where new ideas about wildlife conservation are emerging. From October 2018 to April 2019, nine universities (including "Double First-Class" universities, first-tier universities, second-tier universities), and four three-year colleges in China were selected as survey locations, and face-to-face interviews were conducted with 1991 students. A total of 1977 questionnaires were recovered, of which 1739 were valid, with a completion rate of 88%. A Likert seven-point scale method was used to score students' attitudes, and a classification and regression tree (CART) was used to analyze whether their attitudes were affected by their demographic characteristics. The results show that although students are broadly supportive of the theory of SWM, some are deeply antagonistic about on SWM on issues that arouse strong emotions such as "Animal Welfare and Rights" and "Trophy Hunting". Demographic characteristics of students affect their degree of support for the SWM with support for SWM lower among vegetarians, freshmen, and students who have taken environmental protection electives. This research suggests that the theory of SWM requires to be refreshed and adapted to appeal to the younger generation of Chinese students, with SWM principles integrated into the environmental education programs of universities and three-year colleges. More attention should also be attached to media publicity by the government about wildlife conservation so as to enhance awareness of the need for SWM.

19.
Respir Med ; 173: 106158, 2020 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-33011445

RESUMO

OBJECTIVE: To develop and validate a prediction model for airflow obstruction (AO) in older Chinese. DESIGN: Multivariable logistic regression analysis in large population cohort of Chinese aged ≥50 years. PARTICIPANTS: Model development: 8762 Chinese aged ≥50 years were selected from the early phase recruits to the Guangzhou Biobank Cohort Study (GBCS) (recruited from September 2003 to May 2006). Internal validation: 100 bootstrap samples drawn with replacement from the development sample. External validation: 8395 Chinese aged ≥50 years from later phase GBCS (recruited from September 2006 to January 2008). OUTCOMES: AO was defined by a forced expiratory volume in 1 s/forced vital capacity ratio < lower limits of normal. RESULTS: 839 (9.6%) and 764 (9.1%) individuals had AO in the development and temporal validation samples respectively. The predictors in the prediction model included sex, age, body mass index groups, smoking status, presence of respiratory symptoms, and history of asthma. Model development and validation was stratified by sex. Model performance including calibration (calibration-in-the-large -0.017 vs. -0.157; and calibration slope 0.88 vs. 1.02), discrimination (C-statistic 0.72 vs. 0.63 with 95% confidence interval 0.69-0.75 vs. 0.62-0.73) and clinical usefulness (decision curve analysis) in the external temporal validation sample were more satisfactory in men than that in women. Prediction models with risk thresholds (13% in men and 7% in women) and easy-to-use nomograms were developed to assess the probability of AO. CONCLUSION: The diagnostic models based on readily available epidemiologic and clinical information with satisfactory performance can assist physicians to identify older individuals at high risk of AO and may improve the efficiency of spirometry for active case finding. Further validation beyond the Chinese population is warranted.

20.
J Am Chem Soc ; 2020 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-33044819

RESUMO

Recent advances in spherical mesoporous metal oxides (SMMOs) have demonstrated their enormous potential in a large variety of research fields. However, a direct creation of these materials with precise control on their key shape features, particularly pore architectures, remains a major challenge as compared to the widely explored counterpart of silica. Here, using Al2O3 as an example, we identified that deposition kinetics in solution played an essential role in the construction of different SMMOs. Specifically, a controlled Al3+ precipitation is critical to maintaining the electrostatic interaction between the inorganic precursors and the molecular templates, thereby achieving a designable assembly of these two components toward uniform mesoporous Al2O3-based nanospheres. We demonstrated that such a synthesis strategy is not only able to precisely control the channel orientations from concentric to radial and dendritic, a synthesis capability impeded so far for SMMOs, but is readily applicable to other metal oxides. Our study showed that the growth-kinetics control is a simple but powerful synthesis protocol and opened up a multifunctional platform to achieve systematic design of SMMOs for their future applications.

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