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1.
Environ Pollut ; 255(Pt 2): 113292, 2019 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-31597112

RESUMO

The wide application of bisphenol A (BPA) leads to the emergence of BPA residuals in natural water environments. Dissolved organic matter (DOM) existed in water can bind with BPA, hence influencing the migration and transformation of BPA in aquatic environments. pH is a crucial factor governing the binding interactions between DOM and BPA. However, the mechanisms driven the binding process under different pH conditions are still unclear. In this study, the interactions between BPA and humic acids (HA), a primary component of DOM, are investigated over a wide pH range of 3-12 by integrating fluorescence quenching, dynamic light scattering and microcalorimetry. pH dependence of the binding interactions between HA and BPA are interpreted from a thermodynamic perspective. The results indicate that HA can spontaneously interact with BPA to form a stable HA-BPA complex. With the increasing pH, the binding interactions change from entropy driven to entropy-enthalpy co-driven. Hydrophobic force dominate the binding interactions under acidic condition. The synergy of hydrophobic force and hydrogen bond promotes the binding process under neutral condition. Under alkaline conditions, electrostatic repulsion participates the binding process in addition to hydrophobic force and hydrogen bond, weakening the binding strength. Therefore, neutral pH is favorable for HA to bind with BPA, consequently enhancing the dissolution of BPA in natural water bodies. The results are beneficial to better understand the pH dependent distribution of BPA in aquatic environments.

2.
Nano Lett ; 2019 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-31597431

RESUMO

Using natural membranes to coat nanoparticles (NPs) provides an efficient means to reduce the immune clearance of NPs and improve their tumor-specific targeting. However, fabrication of these drug-loaded biomimetic NPs, such as exosome membrane (EM)- or cancer cell membrane (CCM)-coated poly(lactic-co-glycolic acid) (PLGA) NPs, remains a challenging task owing to the heterogeneous nature of biomembranes and labor-intensive procedures. Herein, we report a microfluidic sonication approach to produce EM-, CCM-, and lipid-coated PLGA NPs encapsulated with imaging agents in a one-step and straightforward manner. Tumor cell-derived EM-coated PLGA NPs consisting of both endosomal and plasma membrane proteins show superior homotypic targeting as compared to CCM-PLGA NPs of similar sizes and core-shell structures in both in vitro and in vivo models. The underlying mechanism is associated with a significantly reduced uptake of EM-PLGA NPs by macrophages and peripheral blood monocytes, revealing an immune evasion-mediated targeting of EM-PLGA NPs to homologous tumors. Overall, this work illustrates the promise of using microfluidic sonication approach to fabricate biomimetic NPs for better biocompatibility and targeting efficacy.

3.
Langmuir ; 2019 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-31600438

RESUMO

Core-shell nanostructures, specifically gold nanorods coated with porous silica (GNR@p-SiO2), were successfully fabricated by surface-protected etching. The nanostructures, photothermal effects, drug loading and drug release behaviors, cellular uptake, and combined chemo-photothermal therapy were investigated. The results showed that the as-prepared GNR@p-SiO2 had a uniform porous silica outer layer . Etching process could be modulated by adjusting the etching time, concentrations of etching agents, and concentrations of protective agents. With doxorubicin (DOX) as the model drug, the drug loading capacity reached 18.9%, which was dependent on the DOX concentrations. The drug release profiles were dual stimulus-responsive to pH and laser irradiation. In addition, the GNR@p-SiO2 nanoparticles were biocompatible and effectively internalized by cancer cells. Compared with chemotherapy or photothermal therapy administered individually, combined chemo-photothermal therapy using GNR@p-SiO2 exhibited higher efficiency in killing cancer cells both in vitro and in vivo. Therefore, surface-protected etching is a powerful method for preparing core-shell nanostructures capped with mesoporous silica for combined cancer chemo-photothermal therapy.

4.
Ecotoxicol Environ Saf ; 185: 109720, 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31585392

RESUMO

INTRODUCTION: Selenium plays important roles in antagonizing the toxicity of methylmercury. The underlying mechanism for the antagonism between Se and MeHg is still not fully understood. OBJECTIVE: The role of gut flora against the toxicity of environmental contaminants is receiving more and more attention. The objective of this study was to investigate the role of Se against MeHg-poisoning in the modulation of gut flora and the decomposition of MeHg. METHODS: MeHg-poisoned rats were treated with sodium selenite every other day for 90 days. Fecal samples were collected on Day 8, 30, 60 and 90. Gut flora in feces was determined using 16S rRNA gene profiling, and the concentrations of Se and total mercury (THg) were measured by ICP-MS, and the concentration of MeHg was measured by CVAFS. RESULTS: Gut flora at both the ranks of phylum and genus in the MeHg-poisoned rats after Se treatment was modulated towards that in the control group, suggesting the restoration of the profile of gut flora. Increased THg was found in fecal samples after Se treatment on day 30. The percentage of MeHg (of total mercury) in the MeHg-poisoned group was in the range of 81-105% while it was 65-84% in the Se treatment group on different days, suggesting the increased decomposition of MeHg in MeHg-poisoned rats after Se treatment. CONCLUSIONS: This study suggests that MeHg poisoning damaged the abundance of gut flora and decreased their capacity for the decomposition of MeHg. After Se treatment, the abundance of gut flora was partially restored and the decomposition and excretion of MeHg was enhanced. These findings suggest that the modulation of gut flora may be one way to promote the health status in MeHg-poisoned rats and possibly in human beings.

5.
Nanomedicine ; : 102092, 2019 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-31593795

RESUMO

Dendritic cell (DC)-targeted vaccines based on nanotechnology are a promising strategy to efficiently induce potent immune responses. We synthesized and manufactured a mannose-modified poly (ß-amino ester) (PBAE) nano-vaccines with easily tuneable and pH-sensitive characteristics to co-deliver the tumour-associated antigen polypeptide Trp-2 and the TLR4 agonist monophosphoryl lipid A (MPLA). To reduce immunosuppression in the tumour microenvironment, an immune checkpoint inhibitor, PD-L1 antagonist, was administrated along with PBAE nano-vaccines to delay melanoma development. We found that mannosylated Trp-2 and MPLA-loaded PBAE nano-vaccines can target and mature DCs, consequently boosting antigen-specific cytotoxic T lymphocyte activity against melanoma. The prophylactic study indicates that combination therapy with PD-L1 antagonist further enhanced anti-tumour efficacy by 3.7-fold and prolonged median survival time by 1.6-fold more than free Trp-2/MPLA inoculation. DC-targeting PBAE polymers have a great potential as a nanotechnology platform to design vaccines and achieve synergistic anti-tumour effects with immune checkpoint therapy.

6.
Analyst ; 2019 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-31595888

RESUMO

The detection of the HPV L1 protein provides information about the infection status of the virus, reflects the replication status of the HPV virus in cervical cells, and helps understand the regression and progress of cervical lesions. Herein, we report a novel laser desorption ionization mass spectrometry (LDI MS) method for the sensitive detection of the HPV 16 L1 protein, based on non-covalent competitive adsorption between the HPV 16 L1 aptamer and melamine on gold nanoparticles (AuNPs). The intensity of the MS signal corresponding to the mass tag shows a linear relationship with the HPV 16 L1 concentration in the range 2-80 ng mL-1, with a limit of detection (LOD) of 58.8 pg mL-1. Using this method, the HPV 16 L1 protein is quantitatively analyzed in both clinical and vaccine samples. The described method is simple and has high sensitivity and good reliability.

7.
Cell Death Dis ; 10(10): 753, 2019 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-31582734

RESUMO

Interleukin (IL)-37, a pivotal anti-inflammatory cytokine and a fundamental inhibitor of innate immunity, has recently been shown to be abnormally expressed in several autoimmune-related orthopedic diseases, including rheumatoid arthritis, ankylosing spondylitis, and osteoporosis. However, the role of IL-37 during osteogenic differentiation of mesenchymal stem cells (MSCs) remains largely unknown. In this study, extracellular IL-37 significantly increased osteoblast-specific gene expression, the number of mineral deposits, and alkaline phosphatase activity of MSCs. Moreover, a signaling pathway was activated in the presence of IL-37. The enhanced osteogenic differentiation of MSCs due to supplementation of IL-37 was partially rescued by the presence of a PI3K/AKT signaling inhibitor. Using a rat calvarial bone defect model, IL-37 significantly improved bone healing. Collectively, these findings indicate that extracellular IL-37 enhanced osteogenesis of MSCs, at least in part by activation of the PI3K/AKT signaling pathway.

8.
Neural Plast ; 2019: 2782417, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31582966

RESUMO

Previous studies have demonstrated that myeloid zinc finger 1 (MZF1) in the dorsal root ganglion (DRG) participates in neuropathic pain induced by chronic-constriction injury (CCI) via regulation of voltage-gated K+ channels (Kv). Emerging evidence indicates that transient receptor potential vanilloid 1 (TRPV1) is involved in the development and maintenance of neuropathic pain. Although it is known that the transcription of TRPV1 is regulated by Kruppel-like zinc-finger transcription factor 7 (Klf7)-and that the structure of TRPV1 is similar to that of Kv-few studies have systematically investigated the relationship between MZF1 and TRPV1 in neuropathic pain. In the present study, we demonstrated that CCI induced an increase in MZF1 and TRPV1 in lumbar-level 4/5 (L4/5) DRGs at 3 days post-CCI and that this increase was persistent until at least 14 days post-CCI. DRG microinjection of rAAV5-MZF1 into the DRGs of naïve rats resulted in a decrease in paw-withdrawal threshold (PWT) and paw-withdrawal latency (PWL) compared with that of the rAAV5-EGFP group, which started at four weeks and lasted until at least eight weeks after microinjection. Additionally, prior microinjection of MZF1 siRNA clearly ameliorated CCI-induced reduction in PWT and PWL at 3 days post-CCI and lasted until at least 7 days post-CCI. Correspondingly, microinjection of MZF1 siRNA subsequent to CCI alleviated the established mechanical allodynia and thermal hyperalgesia induced by CCI, which occurred at 3 days postinjection and lasted until at least 10 days postinjection. Microinjection of rAAV5-MZF1 increased the expression of TRPV1 in DRGs. Microinjection of MZF1 siRNA diminished the CCI-induced increase of TRPV1, but not P2X7R, in DRGs. These findings suggest that MZF1 may contribute to neuropathic pain via regulation of TRPV1 expression in DRGs.

9.
Int J Cancer ; 2019 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-31583695

RESUMO

This study aimed to compare the differences in characteristics and prognoses between Asian and white patients receiving immunotherapy for non-small cell lung cancer (NSCLC). We studied 390 patients who received atezolizumab as part of the POPLAR or OAK trial, and analyzed the differences in baseline characteristics, outcomes, and genetic mutations in blood samples between Asian and white patients. Overall survival (OS) was longer in Asian compared with white patients (median OS: 18.7 vs. 11.1 months; P=0.005). Race was identified as an independent prognostic factor for OS (Asian vs white: hazard ratio 0.647, 95% confidence interval 0.447-0.936, P=0.021), together with performance status, histology, baseline sum of the longest tumor diameters (BLSLD), and number of metastatic sites. The two groups also differed in terms of characteristics including smoking history, BLSLD, epidermal growth factor receptor (EGFR) mutation frequency, programmed death-ligand 1 expression, and blood-based tumor-mutation burden. Blood mutations of STK11, EGFR, KEAP1, POLE, GRM3, ATM, and STAG2 were associated with treatment response, and TP53, KEAP1, APC, RB1, CREBBP, EPHA5, and STAG2 mutations were associated with OS. The blood-based mutation profiles differentiated between Asian and white patients, especially in relation to EGFR (23.8% vs 8.5%), TP53 (30.2% vs 46.9%), and STK11 (1.6% vs 12.3%) mutations (all P<0.05). The different clinicopathological features and mutation profiles in Asian and white patients may explain the superior outcome following atezolizumab treatment in Asian patients with NSCLC. The results of this study have important implications for further studies on racial disparities in relation to immunotherapy. This article is protected by copyright. All rights reserved.

10.
Inorg Chem ; 2019 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-31583885

RESUMO

A metal-organic framework (MOF), named SCNU-Z2, based on a new heterotopic tripodal nitrogen-containing ligand, has been constructed. Due to the replacement of one imidazole group in the reported ligand with one tetrazole group, the charge of the framework is changed from cationic to anionic but retains the same framework structure. The framework consists of tubular channels with a diameter of 1.5 nm and exhibits satisfactory stability in water with a pH range of 3-11. The anionic nature of the framework allows the effective adsorption of the cationic dyes MLB, CV, and RhB with capacities of 455.6, 847.4, and 751.8 mg/g, respectively. Among them, the adsorption capacities for SCNU-Z2 on CV and RhB rank as the highest when compared with other reported MOFs. In contrast, SCNU-Z2 exhibits an extremely low capacity for anionic dyes MO and AO, making it useful for the separation of anionic and cationic dyes based on a charge-dependent mode. Interestingly, SCNU-Z2 can be used to degrade an anionic dye, MB, within 30 min under darkness at room temperature. The apparent activation energy of the dye degradation reaction is calculated to be approximately 18.96 kJ·mol-1, implying that the catalytic reaction of MB can be considered as a low-temperature thermocatalytic reaction in the dark/SCNU-Z2 system.

11.
ChemSusChem ; 2019 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-31584756

RESUMO

Although lithium-sulfur battery is a promising energy storage device with high energy density, environmental friendliness and low cost, many obstacles such as poor conductivity, volume expansion and "shuttle effect" still limit their large-scale commercialization. In this work, a two-dimensional (2D) sandwich-like α-ZrP/polypyrrole (α-ZrP/PPy) material with a nanosheet structure is designed for the sulfur hosting. It is found that such a material can provide unique ion transfer channels for the rapid Li + ions transfer and thusly catalytically promote the lithium polysulfides (LiPSs) conversion. Moreover, the α-ZrP nanosheet provides a true-chemical anchor for sulfur species while the PPy helps to build a physical barrier and form a conductive network for accelerating the electron transport and finally promoting the electrochemical performance. In addition, the moderate catalysis function and efficient true-sulfur-confinement effect of α-ZrP are confirmed by experiments as well as theoretical computations. As a result, α-ZrP/PPy@S cathode exhibits a highly reversible capacity of 727.2 mA·h·g -1 even at a high current density of 5 C, offering a novel cathode material for the high performance Li-S batteries.

12.
Cell Death Dis ; 10(10): 776, 2019 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-31601783

RESUMO

M2-polarized tumor associated macrophages (TAMs) play an important role in tumor progression. It has been reported that response gene to complement 32 (RGC-32) promotes M2 macrophage polarization. However, whether RGC-32 expression in macrophages could play a potential role in tumor progression remain unclear. Here we identified that increasing RGC-32 expression in colon cancer and tumor associated macrophages was positively correlated with cancer progression. In vitro studies confirmed that colon cancer cells upregulated RGC-32 expression of macrophages via secreting TGF-ß1. RGC-32 expression promoted macrophage migration. In addition, stimulation of HCT-116 cells with the condition mediums of RGC-32-silienced or over-expressed macrophages affected tumor cell colony formation and migration via altered COX-2 expression. In an animal model, macrophages with RGC-32 knockdown significantly decreased the expression of COX-2 and Ki67 in the xenografts, and partly inhibited tumor growth. Together, our results provide the evidences for a critical role of TGF-ß1/RGC-32 pathway in TAMs and colon cancer cells during tumor progression.

13.
Cell Death Dis ; 10(10): 772, 2019 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-31601785

RESUMO

Increasing evidence suggested that benzene exposure resulted in different types of hematological cancer. Both autophagy and apoptosis were reported to play vital roles in benzene toxicity, but the relationship between autophagy and apoptosis remain unclear in benzene-induced hematotoxicity. In this study, the toxic effect of benzene on autophagy and apoptosis in benzene-exposed workers and in vitro were verified. Results showed that benzene metabolite (1, 4-benzoquinone, 1, 4-BQ) dose-dependently induced autophagy and apoptosis via enhancing phosphorylation of Bcl-2 and beclin1. Finally, we also found that the elevated ROS was in line with enhancing the phosphorylation of Bcl-2 and beclin1 which contributed to 1, 4-BQ-induced autophagy and apoptosis. Taken together, this study for the first time found that the effect of 1, 4-BQ on the crosstalk between autophagy and apoptosis were modulated by the ROS generation via enhancing phosphorylation of Bcl-2(Ser70) and phosphorylation of beclin1(Thr119), which offered a novel insight into underlying molecular mechanisms of benzene-induced hematotoxicity, and specifically how the crosstalk between autophagy and apoptosis was involved in benzene toxicity. This work provided novel evidence for the toxic effects and risk assessment of benzene.

14.
Zhongguo Zhong Yao Za Zhi ; 44(17): 3758-3762, 2019 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-31602950

RESUMO

Ginsenoside Rh_2,firstly isolated from red ginseng,is protopanaxadiol type of steroidal saponin. Rh_2 possessed variety of activities,but bioavailability of oral administration Rh_2 was extremely low due to poor absorption. Moreover,ginsenoside Rh_2 exhibited toxicity on human normal cells. Therefore,to improve stronger anti-tumor activity and attenuate toxicity,it was essential to design and optimize chemical structure of ginsenoside Rh_2. Through n-octanoylchloride modifications,a novel ester derivative of ginsenoside Rh_2 named caprylic acid monoester of Rh_2( C-Rh_2) was designed and synthesized. Structure of novel ginsenoside derivative was identified by1 D and 2 D NMR,as well as ESI-MS analyses. Anti-tumor effect of C-Rh_2 was tested on H22 tumor bearing mice. C-Rh_2 displayed certain anti-tumor activities and exhibited less toxicity than Rh_2. In the present study,C-Rh_2 as ester form of ginsenoside Rh_2 showed better anti-tumor activity and less toxicity,but the specific mechanism needs further investigation.

15.
Zhongguo Zhong Yao Za Zhi ; 44(17): 3792-3797, 2019 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-31602955

RESUMO

This paper was aimed to establish screening methods of anaphylactoid reaction caused by safflower yellow for injection based on RBL-2 H3 cell degranulation model and mice model for acute anaphylactoid reaction,and evaluate the hypersensitivity caused by safflower yellow for injection from different batches. An in vitro cell model was used to keep the cells stimulated for an hour with different batches of safflower yellow for injection as the drug group,serum-free MEM medium as negative control group and 30 mg·L-1 C48/80 as positive control group respectively. The supernatant was then absorbed,and neutral red staining technique was used to detect the effect of safflower yellow injection on the degranulation of RBL-2 H3 cells with the positive cell rate of degranulation as the indicator.An in vivo model was established to validate the experimental results,and mice model for acute anaphylactoid reaction and ELISA method were adopted to detect the plasma histamine content,and screen the hypersensitivity caused by safflower yellow for injection at the animal level by using plasma histamine content as a test index. The results of the neutral red staining experiments showed that the positive control C48/80 could cause cell degranulation,and most of the cells were deeply stained. There was significant difference in positive cell rate between different batches of safflower yellow and positive control group. In the mice model for acute anaphylactoid reaction,it was found that the positive control C48/80 significantly increased the histamine content in the plasma of mice,while the safflower yellow in each batch did not cause a significant increase in plasma histamine( P<0. 000 1). The mechanism of anaphylactoid reaction is relatively complicated. This study was mainly based on the release of histamine and other active substances by degranulation of mast cells. No significant degranulation reaction of RBL-2 H3 cells induced by safflower yellow for injection was detected,nor was the plasma histamine level significantly increased in mice from the in vitro and in vivo aspects.

16.
J Microsc ; 2019 Oct 11.
Artigo em Inglês | MEDLINE | ID: mdl-31603242

RESUMO

Delicate architecture of active material enables improving the performacne of lithium ion batteries. Environmental-friendly Fe2 O3 anode has high theoretical specific capacity (1007 mAh g-1 ) in lithium ion batteries, but suffers from structural collapsing and poor electronic conductivity. Herein, we design an unique hierarchical iron oxide by regulating the initial precursor prussian blue and targeting hollow-shell structures with full consideration of temperature controls. Among them, Fe2 O3 with a sheet-crossing structure at 650°C, affords obvious advantages of improved electronic conductivity, short ionic diffusion length, prevented particle agglomeration, and buffer volume change. Thus, we achieve a superior discharge specific capacity of 611 mAh g-1 at 500 mA g-1 . Regulating hierarchical structure of prussian blue -assisted oxides enables effectively enchancing Li storge performance. This article is protected by copyright. All rights reserved.

17.
Blood Press Monit ; 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31577550

RESUMO

OBJECTIVE: To evaluate the accuracy of the YuWell YE680B oscillometric upper-arm blood pressure monitor for clinic and home blood pressure measurements in adults according to the American National Standards Institute/the Association for the Advancement of Medical Instrumentation/International Organization for Standardization (ANSI/AAMI/ISO) 81060-2:2013 standard. METHOD: Eighty-five subjects (male 46 and female 39) with a mean age of 44.6 years were recruited to fulfill the age, sex, blood pressure, and cuff distribution criteria of the ANSI/AAMI/ISO standard in the general population using the same arm sequential blood pressure measurement method. Two differently-sized cuffs were used for arm circumferences 22-32 cm (medium) and 22-45 cm (large), respectively, for the test device, and for arm circumferences ≤32 cm (standard) and >32 cm (large), respectively, for the mercury sphygmomanometer. RESULTS: A total of 255 comparison pairs were obtained for analysis. For validation criterion 1, the mean ± SD of the differences between the test device and reference systolic/diastolic blood pressure readings was -2.2 ± 7.2/-3.9 ± 5.2 mmHg. For validation criterion 2, the SD of the averaged systolic/diastolic blood pressure differences between the test device and reference blood pressure per subject was 5.70/4.67 mmHg. CONCLUSION: The automated upper-arm blood pressure monitor YuWell YE680B has passed the requirements of the ANSI/AAMI/ISO81060-2:2013 standard, and hence can be recommended for blood pressure measurement in the general population.

18.
Chem Commun (Camb) ; 2019 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-31580361

RESUMO

A cobalt(ii) tetrakis(2,3,5,6-tetrafluoro-4-ethynylphenyl)porphyrin (FCoP-H) was designed and synthesized. With carbon-nanotube-templated polymerization, covalent porphyrin frameworks using FCoP-H can be synthesized via the Hay-coupling. The resulting FCoP@CNT is efficient to catalyze the hydrogen evolution reaction (HER) in aqueous media, and its performance is superior, in terms of both lower overpotentials and larger catalytic currents, to covalent porphyrin frameworks using non-fluorinated cobalt porphyrin analogues and also monomeric fluorinated cobalt porphyrins simply adsorbed on CNTs. This work combines the merits of CNT-templated covalent frameworks and fluorinated cobalt porphyrins to significantly improve the HER performance. This strategy is valuable to be explored in other electrocatalytic systems using molecule-engineered carbon materials.

19.
Ultrasound Med Biol ; 2019 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-31582180

RESUMO

The aim of this study was to investigate the relationship between morphologic characteristics of the calcifications detected by ultrasound in thyroid nodules and thyroid carcinoma. Morphologic characteristics of the calcifications on pre-operative ultrasound examinations of thyroids were compared with post-operative pathologic diagnoses in 543 patients undergoing thyroid surgery. Calcifications were divided into microcalcifications (≤2 mm) and macrocalcifications (>2 mm), and the latter were divided into eggshell calcifications in a row, eggshell discontinuous calcifications, irregular calcifications and multilayer-like calcifications, labeled types I-V. We found that thyroid microcalcifications and partial macrocalcifications, such as eggshell discontinuous calcifications, and multilayer-like calcifications were associated with thyroid carcinoma. In conclusion, microcalcifications were more commonly found in malignant thyroid nodules, particularly in papillary thyroid carcinoma. Eggshell discontinuous macrocalcifications and multilayer-like macrocalcifications also occurred mainly in malignant nodules.

20.
J Colloid Interface Sci ; 558: 115-122, 2019 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-31585220

RESUMO

Chromatic fibers that change color in response to external stimuli are expected to be widely used in various applications such as anti-counterfeiting, military camouflage, and wearable displays. Advanced chromatic fibers with polychromatic and editable color properties behavior are strongly desired for practical applications but have not yet been realized using existing spinning technologies. Here, we present the low-cost, continuous microfluidic spinning of editable polychromatic polylactide (PLA) fibers. The structure and performance of the polychromatic PLA fibers were precisely controlled by adjusting the parameters used in microfluidic spinning. The structure of the as-spun products evolved through three different stages based on the editable encapsulation of functional materials into the PLA matrix. Fibers with versatile performance were achieved. A beaded polychromatic PLA fiber showed the possibility to delivery coded information through its editable chromatic behavior. A core-shell polychromatic PLA fiber showed good mechanical properties and knittability, which make it promising to fabricate smart color-changing textiles.

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