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1.
J Hazard Mater ; 382: 121043, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31450207

RESUMO

Aerobic granular sludge-based simultaneous nitrification, denitrification and phosphorus removal (SNDPR) systems were configured for the treatment of low-strength municipal wastewater. Granular characteristics, process performance, and the corresponding microbial ecology dynamics were comprehensively explored with sodium acetate and succinate as mixed carbon source. Results revealed that aerobic granules kept structural and functional resilience, while mixed carbon source largely altered and balanced the growth and competition of phosphorus/glycogen accumulating organisms (PAOs/GAOs). Appropriate ratio of mixed carbon source was vital for superb physiochemical behaviors and reliable removal performance by aerobic granules. Therefore, the aerobic granular SNDPR system could achieve deep-level nutrients removal through enhancing the anaerobic carbon uptake rate and strengthening the carbon usage efficiency. The present work could add some guiding sight into the application of aerobic granular SNDPR system for wastewater treatment.

2.
J Mot Behav ; 52(1): 58-70, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-30848722

RESUMO

The present study investigates the effect of sensory deprivation of the index and middle finger on motor function of all digits during maximal voluntary force production tasks. A total of 27 subjects performed maximal isometric pressing tasks by using different instructed finger combinations. Subjects completed the same tasks in two visits: a control visit when they had normal sensory feedback in all fingers, and an anesthesia visit when digital nerve blocks were performed on their right index and middle fingers. We evaluated three aspects of motor adaptation on both local (anesthetized) and non-local (non-anesthetized) digits during maximal force production: (1) task-relevant and overall force magnitude, (2) force directional application, and (3) digital individuation and force sharing. Our results indicate that selective digital anesthesia resulted in decreased maximal force magnitude, changed direction of force production, and significant changes extended to non-local digits. The motor weakness and inefficiency revealed in the non-local digits implies that sensory information from each digit can be shared across the digits to assist motor execution within the same hand.

3.
Ultrasound Med Biol ; 46(1): 20-25, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31582180

RESUMO

The aim of this study was to investigate the relationship between morphologic characteristics of the calcifications detected by ultrasound in thyroid nodules and thyroid carcinoma. Morphologic characteristics of the calcifications on pre-operative ultrasound examinations of thyroids were compared with post-operative pathologic diagnoses in 543 patients undergoing thyroid surgery. Calcifications were divided into microcalcifications (≤2 mm) and macrocalcifications (>2 mm), and the latter were divided into eggshell calcifications in a row, eggshell discontinuous calcifications, irregular calcifications and multilayer-like calcifications, labeled types I-V. We found that thyroid microcalcifications and partial macrocalcifications, such as eggshell discontinuous calcifications, and multilayer-like calcifications were associated with thyroid carcinoma. In conclusion, microcalcifications were more commonly found in malignant thyroid nodules, particularly in papillary thyroid carcinoma. Eggshell discontinuous macrocalcifications and multilayer-like macrocalcifications also occurred mainly in malignant nodules.

4.
Addict Behav ; 101: 105976, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31101387

RESUMO

PURPOSE: The current study attempts to clarify the mediating role of cognitive function on the relationship between environmental pressure (pressure caused by negative parenting styles and dysfunctional school environments) and Internet Use Disorder (IUD); this study explores the effects of sex and left-behind children (LBC). METHODS: A cross-sectional sample of adolescents aged 12-15 years was recruited in 2018. A total of 3048 junior high school adolescents in rural areas of the Sichuan province in western China completed a series of psychological inventories, including the Adolescent Pathological Internet Use Scale (APIUS), the Junior High School Students' Perceived School Climate Inventory (PSCI-M), the Egna Minnen av. Barndoms Uppfostran (EMBU), and the Mental Health Screening Inventory for Children and Adolescents (MHS-C), for an analysis of IUD, school climate, parenting styles and cognition, respectively. RESULTS: Among the participants, 18.5% (N = 565) exhibited significant symptoms of IUD. The correlation analysis showed that IUD was positively correlated with parents' punishment, rejection and over-interference and academic pressure, whereas IUD was negatively associated with good teacher-student relationships, good schoolmate relationships and cognitive function scores. Structural equation modelling (SEM) showed that cognitive function partially contributed to the association between family and school pressures and IUD. DISCUSSION: Cognitive function is one of the mediating pathways through which environmental pressures may predict IUD among junior high school students. Interventions may target the mediating pathway of cognitive function to alleviate the negative impact of environmental pressure on IUD.

5.
Int J Cancer ; 146(2): 475-486, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31107971

RESUMO

Long noncoding RNAs (lncRNAs) promote cell proliferation, migration, invasion and castration resistance in prostate cancer (PCa). Understanding the inherited molecular mechanisms by which lncRNAs contribute to the progression of PCa to a lethal disease could have an important impact on cancer detection, diagnosis and prognosis. In our study, PCa-associated lncRNA transcripts from RNA-seq data were identified and screened via bioinformatics analysis, NCBI annotations and literature review. We identified a novel lncRNA, lncAPP (lncRNA activated in PCa progression), which activates in PCa progression and is expressed in primary tumor tissues and urine samples of patients with localized or advanced PCa. Urinary-based lncAPP is a promising biomarker for predicting PCa progression. In vitro and in vivo studies demonstrated that lncAPP enhanced cell proliferation and promoted migration and invasion. The underlying mechanism of lncRNA was investigated by RNA immunoprecipitation, dual-luciferase reporter system assay, etc. Upregulation of lncAPP promoted cell migration and invasion via competitively binding miR218 to facilitate ZEB2/CDH2 expression. In addition, in vivo subcutaneous tumor xenograft models and tail intravenously injection metastatic models were constructed to evaluate lncRNA function. Targeting lncAPP/miR218 axis in cell lines and tumor xenografts restrained tumor progression properties both in vitro and in vivo. These results establish that lncAPP/miR218 axis plays a critical role in PCa progression, and they also suggest new strategies to prevent tumor progression for therapeutic purposes.

6.
Mater Sci Eng C Mater Biol Appl ; 107: 110309, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31761185

RESUMO

Release behaviors of drugs from drug deliveries are crucial for the enhancement of therapy efficiency, reduction of toxicity and patient compliance. Herein, antisolvent crystallization is employed to coat methlyene blue (MB)-loaded silica by shellac precipitation (silica-MB@shellac), which is simultaneously induced by outward diffusion of H+ ions from particular silica-MB. The encapsulation of shellac shell on silica-MB modulates the aggregation state of MB, which endows silica-MB@shellac a decreased MB's thermal stability, enhanced photoluminescence intensity, improved stability against in vitro reduction by ascorbic acid and retained photodynamic therapy activity. From the absorbance of MB supernatant obtained during incubation, the concentrations of MB monomers and dimers are determined via a non-linear regression analysis to investigate the influence of shellac coating on MB's release mechanisms from silica-MB@shellac. According to the simulated models, small diffusion constants of MB are caused by limited diffusion through shellac shells with high compaction degrees. These are observed for samples synthesized under high supersaturation degree during antisolvent crystallization. High degree of supersaturation is achieved through increasing shellac concentration, additive amount and dropping rate of antisolvent, as well as decreasing pH values of aqueous buffers as antisolvent. Furthermore, a combined mechanism of Fickian diffusion and Case-IΙ relaxation is proposed to describe the release behaviors of MB monomer and dimers from silica-MB@shellac. Therefore, this work may shed light on the encapsulation method of polymer on drug-loaded powders and the control of aggregation states of photosensitizers to promote the photoluminescence intensity, photodynamic therapy efficiency and controlled release behaviors.

7.
J Colloid Interface Sci ; 558: 115-122, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31585220

RESUMO

Chromatic fibers that change color in response to external stimuli are expected to be widely used in various applications such as anti-counterfeiting, military camouflage, and wearable displays. Advanced chromatic fibers with polychromatic and editable color properties behavior are strongly desired for practical applications but have not yet been realized using existing spinning technologies. Here, we present the low-cost, continuous microfluidic spinning of editable polychromatic polylactide (PLA) fibers. The structure and performance of the polychromatic PLA fibers were precisely controlled by adjusting the parameters used in microfluidic spinning. The structure of the as-spun products evolved through three different stages based on the editable encapsulation of functional materials into the PLA matrix. Fibers with versatile performance were achieved. A beaded polychromatic PLA fiber showed the possibility to delivery coded information through its editable chromatic behavior. A core-shell polychromatic PLA fiber showed good mechanical properties and knittability, which make it promising to fabricate smart color-changing textiles.

8.
J Hazard Mater ; 383: 121099, 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-31518808

RESUMO

High CO2 emissions during the production process of ordinary Portland cement (OPC) promoted greener-cement development, wherein the application of magnesium oxychloride cement (MOC) can add value to waste in potash industry and reduce environmental hazards. However, its application was restricted by its inferior water resistance. It's a challenge to remarkably increase both the compressive strength and water resistance of MOC. Herein, we demonstrate that cornstarch/sodium polyacrylate (PAAS) MOC composites exhibit increased compressive strength and water resistance. Moreover, the biomineralization process encourages the growth and alignment of phase 5 crystals by a cornstarch template with hydroxyl groups, thus enhancing the compressive strength of MOC. The chelation of magnesium ions and the transformation of phase 5 crystal structure by PAAS can significantly enhance the water resistance of MOC. This composite exhibits a 21.0% increase in compressive strength, and the softening coefficient is also increased from 0.48 to 0.81 in comparison with unmodified-MOC. Meanwhile, the hydrogen bonds between cornstarch and elemental Cl obviously decrease the efflorescence phenomena of the MOC. This MOC composite with a markedly increased compressive strength and water resistance, which was prepared by a facile and green method, may have potential applications in building development and the replacement of OPC.

9.
J Hazard Mater ; 383: 121169, 2020 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-31520931

RESUMO

Nickel (Ni) contamination in soils, at high concentrations, is considered to be very common. Knowledge of the total content of Ni is frequently insufficient to estimate environmental risk. Our explored findings showed that the earthworms adding reduced the available Ni, along with the superior performance of HCl than CaCl2. The bioaccumulation of Ni in earthworms was aggravated with increasing Ni dosage and exposure time. Bioaccumulation factor was significantly correlated with the extractable Ni, which was the most suitable predicting the variations of Ni bioavailability. LC50 of earthworms on 7 and 14 days were 1202.444 mg kg-1 and 1069.324 mg kg-1, respectively along with the recovery rate in 500 mg kg-1 Ni polluted soil reached up to 92.5%. Earthworms' respiration was sensitive presenting a significant dose-effect relationship with the Ni concentration. Five biochemical indices in earthworms were induced along with the relevance of a dose- and time-response pattern. Additionally, histological damage in earthworm's body wall, intestine and seminal vesicles were observed under high level of Ni exposure. Overall, we believe that our current study will open a new window for deeper insights into the potential availability of Ni along with other associated metals on the function of soil ecosystem.

10.
Acta Pharm ; 70(1): 35-47, 2020 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-31677374

RESUMO

Allergic rhinitis (AR) is a common disease that causes severe inflammation and even disabilities. Previous studies have reported baicalein to have an anti-inflammatory effect. However, the pharmacological action of baicalein on anaphylaxis has not been clarified yet. This study assessed the in vivo protective effect of baicalein post-treatment in an ameliorating ovalbumin (OVA)-sensitized AR rat model. Baicalein attenuated histological alterations, aberrant tissue repair and inflammation after OVA-induced AR. Baicalein reduced the frequency of nasal/ear rubs and sneezes in rats, and inhibited generation of several inflammatory cytokines (TNF-α, IL-1ß, and IL-6) in both blood and nasal lavage of rats. Infiltrations of eosinophils, lymphocyte, and neutrophils were decreased in baicalein-administered rats. Furthermore, baicalein inhibited the expression of STAT3 phosphorylation in the nasal mucosa. In summary, baicalein attenuated OVA-induced AR and inflammation, which suggests it as a promising therapeutic agent for the alleviation of AR-associated inflammation and pathology.

11.
Ecotoxicol Environ Saf ; 187: 109859, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31677573

RESUMO

Chrysanthemum (Dendranthema grandiflora) flowers are consumed as a popular, traditional herbal tea worldwide. During tea infusion with hot water pesticide residues in chrysanthemum flowers can be transferred into tea solution, posing potential health risks to consumers. Using greenhouse chrysanthemum this study systematically investigated the transfer of metalaxyl-M, fludioxonil, cyantraniliprole, thiamethoxam, and clothianidin (a major metabolite of thiamethoxam) from dry chrysanthemum flowers to tea solution at a range of infusion repetitions, duration and water temperature. The tested pesticides were released into tea solution at varying degrees, and the maximum transfer percentage was 59.9%, 9.8%, 29.4%, 88.2% and 68.4% for metalaxyl-M, fludioxonil, cyantraniliprole, thiamethoxam, and clothianidin, respectively. The transfer of pesticides into tea solution generally increased with increasing pesticide water solubility, water temperature, infusion duration, and pesticide concentrations in dry chrysanthemum flowers, but decreased with increasing octanol-water partition coefficient and the number of infusion repetitions. Risk quotient for pesticide intake via consuming tea solution of chrysanthemum flowers (one and two times of recommended pesticide dosages) ranged from <0.00003 to 0.0924, indicating a low health risk. This study provides useful information for risk assessment of pesticide residues in greenhouse chrysanthemum flowers and may help establish realistic maximum residue limit of pesticides in chrysanthemum flowers and tea solution.

12.
Spectrochim Acta A Mol Biomol Spectrosc ; 224: 117413, 2020 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-31369990

RESUMO

The twelve Λ-S electronic states of the first four dissociation limits of the MgSb molecule have been examined at the icMRCI+Q level employing basis sets of quintuple-ζ quality. The potential energy curves, vibrational levels and spectroscopic constants of the species have been investigated. The permanent dipole moments of the interested states are derived, and the transition dipole moments, Einstein emission coefficients, radiation lifetimes and Franck-Condon factors between selected states are also determined. Four Λ-S states of the first two dissociation limits split into seven Ω states under the effect of spin-orbit coupling. Characterizations of the MgSb low-lying Ω states are performed for the first time. In addition, the results and relevant data provided in this work on MgSb are compared with the antimony-IIA group and magnesium-VA group diatomic species. It is anticipated that this work will shed some light on further investigations of MgSb and other antimony-IIA group systems.

13.
Ultrasonics ; 100: 105981, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31479965

RESUMO

Porosity is an integral part of thermal barrier coatings (TBCs) and is required to provide thermal insulation and to accommodate operational thermal stresses. Accurate characterization of the TBCs porosity is difficult due to the complex pore morphology and ultra-thin coating thickness. In this paper, a BP neural network optimizing Gaussian process regression (GPR) algorithm, termed BP-GPR, is presented to characterize the TBCs porosity based on a constructed ultrasonic reflection coefficient amplitude spectrum (URCAS). The characteristic parameters of URCAS are optimized through the BP neural network combined with a high determination coefficient R2 rule. Then the optimized parameters are utilized to train the GPR algorithm for predicting the unknown TBCs porosity. The proposed BP-GPR method was demonstrated through a series of finite element method (FEM) simulations, which were implemented on random pore models (RPMs) of plasma spraying ZrO2 coating with a thickness of 300 µm and porosities of 1%, 3%, 5%, 7%, and 9%. Simulation results indicated the relative errors of the predicted porosity of RPMs were 6.37%, 7.62%, 1.07%, and 1.07%, respectively, which has 32% and 48% accuracy higher than that predicted only by BP neural network or GPR algorithm. It is verified that the proposed BP-GPR method can accurately characterize the porosity of TBCs with complex pore morphology.

14.
Food Chem ; 306: 125613, 2020 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-31610331

RESUMO

Reduction of bitter taste in protein hydrolysates is a challenging task. The aim of this study was to apply a simple two-step approach to prepare low bitter hydrolysates and investigate the influence of peptide modifications on taste characteristics. Protein hydrolysates were prepared from porcine muscle and plasma through simultaneous hydrolysis using endo- and exo-peptidases combined with peptide glycation by glucosamine (GlcN). Spectroscopic analysis and quantification of major alpha-dicarbonyl compounds (α-DCs) indicated the relatively low extent of Maillard reaction in GlcN-glycated protein hydrolysates. Thermal degradation of high MW peptides (>10 kDa) might play a major role in Maillard reaction, reflected by the formation of more Maillard reacted peptides (1-5 kDa), especially in plasma samples. Sensory evaluation indicated that glycation by GlcN can alter taste profiles of protein hydrolysates, which may be attributed to the formation of Maillard reacted peptides and peptide modifications revealed by LC-MS/MS analysis.

15.
Transgenic Res ; 2019 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-31673914

RESUMO

The vitamin E family includes tocopherols and tocotrienols, which are essential lipid-soluble antioxidants necessary for human and livestock health. The seeds of many plant species, including maize, have high gamma (γ)-tocopherol but low alpha (α)-tocopherol contents; however, α-tocopherol is the most effective antioxidant. Therefore, it is necessary to optimize the tocopherol composition in plants. α-Tocopherol is synthesized from γ-tocopherol by γ-tocopherol methyltransferase (γ-TMT, VTE4) in the final step of the tocopherol biosynthetic pathway. In the present study, the full-length coding sequence (CDS) of γ-TMT was isolated from Zea mays, named ZmTMT. The ZmTMT CDS was 1059 bp in size, encoding 352 amino acids. Recombinant ZmTMT was expressed in Escherichia coli and the purified protein effectively converted γ-tocopherol into α-tocopherol in vitro. A comparison of enzyme activities showed that the activity of ZmTMT was higher than that of GmTMT2a (Glycine max) and AtTMT (Arabidopsis thaliana). Overexpression of ZmTMT increased the α-tocopherol content 4-5-fold in transgenic Arabidopsis and around 6.5-fold in transgenic maize kernels, and increased the α-/γ-tocopherol ratio to approximately 15 and 17, respectively. These results show that it is feasible to overexpress ZmTMT to optimize the tocopherol composition in maize; such a corn product might be useful in the feed industry in the near future.

16.
Opt Express ; 27(19): 27076-27087, 2019 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-31674575

RESUMO

Self-mixing velocity sensor based on a mutual-injected two-element terahertz quantum cascade laser (THz QCL) array is studied theoretically. The working characteristics of mutual-injected THz QCL array with different frequency detunings and self-mixing feedback strengths, as well as their influences on the self-mixing measurements are discussed in detail. Within the phase-locked range, each laser in the array reaches a stable state rapidly and can be used as a self-mixing detector due to the mutual injection coupling. The array will no longer be phase-locked when the frequency detuning of the lasers is too large, and only the laser that receives the feedback light can still be used for self-mixing velocity measurements. It is also found that even for the case of strong feedback, the THz QCLs will not be completely unstable and the self-mixing velocity measurements could also be possible. In addition, the simulation also shows that the array could measure two independent moving targets simultaneously. These results provide the theoretical support for the future applications of THz QCL arrays in self-mixing sensors.

17.
Opt Express ; 27(19): 27168-27182, 2019 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-31674583

RESUMO

The principle of superposition is a key ingredient for quantum mechanics. A recent work [Phys. Rev. Lett.116, 110403 (2016)10.1103/PhysRevLett.116.110403] has shown that a quantum adder that deterministically generates a superposition of two unknown states is forbidden. Here we consider the implementation of the probabilistic quantum adder in the 3D cavity-transmon system. Our implementation is based on a three-level superconducting transmon qubit dispersively coupled to two cavities. Numerical simulations show that high-fidelity generation of the superposition of two coherent states is feasible with current circuit QED technology. Our method also works for other physical systems such as two optical cavities coupled to a three-level atom or two nitrogen-vacancy center ensembles interacted with one three-level superconducting flux qubit.

18.
Telemed J E Health ; 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31674890

RESUMO

Background: User-generated content shared in the online health communities (OHCs) is becoming a valuable resource for researchers to understand patients' decision-making behaviors in the management of their health. Many studies have focused on how to obtain useful information from online reviews in OHCs. Introduction: This study focuses on a telemedicine service called Online Private Doctor (OPD), which is offered by a leading Chinese physician review website (PRW). OPD reviews have not received much attention. By data mining the reviews, our goal is to determine what patients are talking about when they use the OPD service and whether they are satisfied with the service or not. Materials and Methods: We used a Python web crawler to collect 41,029 reviews and 84,510 short reviews (labels) of all 5,645 physicians who offered the OPD service on a PRW (haodf.com) in China. Mixed methods (i.e., a literature review, topic discovery, annotation, and a sentiment analysis) were used to determine the information that the OPD reviews are meant to express. Results: We discovered that the OPD reviews can be categorized into four subjects: competence (35.1%), communication (29.4%), treatment (26.0%), and convenience (9.5%). In terms of previously discovered topics, we found that competence, communication, and treatment have been discussed before, but convenience is an emerging subject. The sentiment analysis indicated that 93.67% of the reviews indicated positive emotions, and the area under the receiver operating characteristic (ROC) curve is 0.64. Furthermore, the labels indicated that only 0.72% (603/84,570) of reviews were negative toward the OPD service. The subjects of the labels were distributed according to competence (34.7%), communication (23.8%), treatment (33.5%), and convenience (8.0%). Discussion: The findings of our study suggest that patients who ever used OPD have been quite satisfied with the service. From their reviews, we discovered that OPD has its special characteristics and is convenient. However, it still has some shortcomings, for example, the quality of the phone connection. In terms of both the platform and the doctors, more efforts should be made to make the OPD better and more regulated. Conclusion: OPD is an emerging telemedicine service that still needs more time and space to evolve. For patients, it helps reduce problems such as scheduling and queuing. Therefore, it brings more convenience to people's daily lives. In the future, more attention should be paid to this service, as it is helpful in reducing the uneven distribution of medical resources.

20.
Oral Dis ; 2019 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-31696592

RESUMO

This study aims to investigate the levels of SLIT3 in gingival crevicular fluid (GCF) of healthy and periodontal disease subjects, and their correlations to periodontal disease. A total of 45 periodontal patients and 45 periodontally healthy volunteers were enrolled. The clinical parameters, radiographic bone loss and the levels of SLIT3, receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG) in GCF were measured. The prevalences of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia in subgingival plaque were also analyzed. The expression of SLIT3 and RANKL was detected in the periodontium of experimental periodontitis in rats and lipopolysaccharide (LPS)-induced mouse macrophage. The total amounts and concentrations of SLIT3 and RANKL were significantly higher in periodontitis than those in healthy, while the level of OPG was significantly lower (p < .05). Significant positive correlations were observed between the level of GCF SLIT3 and clinical attachment level and radiographic bone loss (p < .05). There existed a significant positive correlation between SLIT3 and RANKL (p < .05). Increased expression of SLIT3 and RANKL was observed in the periodontium of periodontal rats. SLIT3 expression was induced by LPS stimulation in macrophages. These results suggest that SLIT3 may act as a diagnostic indicator of periodontal disease and should be further investigated.

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