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1.
Injury ; 2020 Jun 23.
Artigo em Inglês | MEDLINE | ID: mdl-33023742

RESUMO

PURPOSE: To repair multiple skin soft tissue defects of one finger is a challenge to hand surgeons. We introduce a method which can be used to repair multiple skin soft tissue defects of one finger with bilateral flaps in parallel pattern flap based on the dorsal branches of the proper digital artery. METHOD: A patient suffered electric injury in her left index finger with two soft tissue defects, and the areas were 1.6 cm × 1.0 cm and 2.2 cm × 1.2 cm, respectively. And who underwent a homodigital parallel flaps based on the dorsal branches of the proper digital artery to repair in January 2018. The donor sites were covered by full-thickness skin grafting. RESULTS: The flaps and the skin grafting survived uneventfully. All incisions achieved primary healing. The follow-up was 19 months, and the shape of the flaps was satisfactory with soft texture and suitable appearance. TAM of the injured finger was 210°, the level was excellent. The score of VAS was 9. CONCLUSION: The homodigital bilateral flaps in parallel pattern based on the dorsal branches of the proper digital artery are a potential treatment in one-stage for multiple skin soft tissue defects of one finger with reliable blood supply, satisfactory results and simple surgical procedure.

2.
J Environ Manage ; 277: 111382, 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-33069143

RESUMO

The efficiency, accuracy and universality of ecological assessment methods comprise an important foundation for comprehensive assessment and restoration of large river ecological health at the watershed scale. New evaluation metrics and methods are urgently needed to be developed to adapt the characteristics of large rivers, including geographical differences in surface runoff, regional ecological complexity, and seasonal changes. In this study, a bacteria-weighted index of biotic integrity was developed to assess the ecological health of large rivers (lrBW-IBI) based on compositional and functional characteristics of sediment bacterial communities from 33 sections of the lower mainstream of Yangtze River. Five key metrics were determined by range, responsiveness, and redundancy tests. Principal component analysis (PCA), entropy method, criteria importance through intercriteria correlation and random forest were applied to calculate weighted coefficients of key metrics. The optimal lrBW-IBI was observed through the sum of PCA weighted-metrics: the relative abundance of Latescibacteria (0.234), Gemmatimonadaceae (0.149), Nitrospira spp. (0.234), Rhizobiales (0.228), and nitrogenase NifH (0.156). According to PCA based lrBW-IBI, 12.12%, 24.24%, 39.39%, and 24.24% of river sections were labeled excellent, good, moderate, and relatively poor, respectively. The ecological status of the lower mainstream of the Yangtze River did not change significantly across seasons but declined gradually from upstream to downstream. This study provides a new assessment tool for the ecological health of large rivers and highlights the importance of microbial ecological index in river ecology.

3.
Biomark Med ; 2020 Oct 16.
Artigo em Inglês | MEDLINE | ID: mdl-33064019

RESUMO

Aim: This study examined the role of lymphocyte-to-monocyte ratio (LMR), an inflammatory biomarker, in predicting the severity of calcific aortic valve stenosis (CAVS) in a Chinese case-control study. Results: The LMR significantly decreased in the patients with CAVS compared with healthy controls. An inverse correlation was observed between the severity of stenosis and LMR in the patients. Additionally, the LMR was identified in the multivariate analysis as an independent predictor of severe CAVS. Conclusion: This study provides evidence of an inverse correlation between the severity of CAVS and LMR. LMR could potentially be applied as an independent predictor of severe CAVS and could be incorporated into a novel predictive model.

4.
J Musculoskelet Neuronal Interact ; 20(3): 398-403, 2020 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-32877976

RESUMO

OBJECTIVES: To explore the role of medial collateral ligament repair in knee osteoarthritis based on TLR4/ MyD88/ NF-κ inflammatory signaling pathway. METHODS: The modified Hulth method was used to establish models, which were divided into a repair group, a model group, and a sham operation group. The repair group was treated with medial ligament repair technology. Synovium and cartilage morphological changes were evaluated by hematoxylin-eosin staining to determine the degree of reparation. The cartilage was evaluated by the Mankin's score, and inflammatory factors in cartilage tissues were determined by ELISA. The changes in TLR4, MyD88, and NF-κB levels were analyzed using the real-time quantitative PCR and Western blot assays. RESULTS: The synovial and cartilage damages in the repair group and the sham operation group were significantly alleviated compared to the model group. The Mankin's score of the model group was significantly lower than the other two groups. The expression of inflammatory factors in the repair group and the sham operation group were significantly lower than in the model group. The expressions of those factors in the repair group and the model group were higher than those in the model group. CONCLUSIONS: Medial ligament repair can improve the cartilage morphology and delay the development and progression of knee osteoarthritis by inhibiting the TLR4/MyD88/NF-κB signaling pathway.

5.
J Clin Ultrasound ; 2020 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-32964466

RESUMO

We treated successfully a man with a femoral artery pseudoaneurysm by ultrasonography-guided application of a suture-mediated closure device. Radiography was not needed, as a guide wire was placed into the femoral artery along the rupture under ultrasonographic guidance alone, and the femoral artery was then sutured with the vascular closure device. The pseudoaneurysm was then completely resolved. This novel approach, which minimizes risks and costs, may be a safe and acceptable option to control iatrogenic pseudoaneurysms, especially when thrombin injection is not feasible.

6.
Environ Res ; 192: 110266, 2020 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-32997966

RESUMO

Understanding the ecological relationship of microbial community under external stimulation is crucial for environmental restoration. Black carbon (e.g., biochar) have been widely deemed as a strategy to enhance pollutants removal because of its structure and redox-active property. However, the underlying ecological mechanism of microbial community under black carbon addition is poorly understood. The major purposes of this study were to determine the microbial assemblage and functional patterns via null model test, network analysis, and function prediction. The results showed that the nitrate removal efficiency of modified black carbon system achieved 46.44%. Both deterministic and stochastic processes were significant for mediating the microbial assemblage and the deterministic process dominated (>95%) the assemblage of community. Keystone taxa in the black carbon systems, involving Sulfuricella, Allorhizobium, and Nitrospira, stimulated the shift of community composition regarding the nitrogen removal. The existence of black carbon and the biotic interactions increased biological nitrate utilization and promoted nitrogen removal. Overall, this study presents the mechanism of bacterial community assembly and provides insight into biological nitrogen removal from microbial ecological perspective.

7.
Artigo em Inglês | MEDLINE | ID: mdl-32827298

RESUMO

Rapid urbanization has been recognized as the primary cause of deteriorating water quality. Thus, it is crucial to take into account urbanization in water quality forecasting. The present study aims at finding the causal relationship between urbanization and water quality, and then predicting water quality based on this causality. For this purpose, nine urbanization indicators and 12 water quality parameters from 2006 to 2018 in Nanjing were collected as urbanization and water quality indices. Correlation and path analyses were firstly used to identify causal relationships between urbanization and water quality indices. Based on these causal relationships, comprehensive water quality indicators and their correlated urbanization parameters were input into a back-propagation neural network (BPNN) to predict water quality. In the improved BPNN, the R2 of the training sets were all greater than 0.99, and those of the test sets were all greater than 0.76, demonstrating that the optimized model is able to predict the water quality with reasonable accuracy. It also showed that the overall water quality in Nanjing will remain good from 2019 to 2028, which means that, when undergoing future urbanization process, water quality is not necessarily negatively affected. The transfer of industrial structure can have a positive influence on water quality. After 2028, the biological water environment index remained in a good state but the volatile phenol index continued to increase, making it a potential threat to future water quality. Industrial wastewater and fertilizer usage, as the primary sources of volatile phenols, should be prioritized for continued governmental control and monitoring into the future. This study provides new insight into the relationship between urbanization and water quality, and the presented models can assist in future-proofing water management strategies.

8.
Environ Sci Technol ; 54(18): 11237-11248, 2020 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-32790991

RESUMO

Understanding the characteristics of biogeochemical processes in urban channel confluences is essential for the evaluation and improvement of water environmental capacity. However, influences of biogeochemical processes in confluence were always overlooked or simply parametrized since the transformation processes controlled by microbial community assembly were hard to quantify. To address this knowledge gap, the present study proposed a novel mathematical modeling system, based on microbial community assembly theory and fluid kinetics, to decouple nitrogen dynamics into flow-induced transport and microorganism-induced transformation processes, and quantified their contributions to nitrogen concentrations. Results revealed that variable selection processes (including hydrodynamic conditions) contributed to significant difference in microbial communities among different hydraulic regions. Variation in microbial communities further shifted transformation processes. Rhodobacterales and Sphingomonadales, which were reported to be vital participants in denitrification process, were enriched in flow separation region, and promoted it as a hotspot for nitrogen removal. In the flow separation region, microorganism-induced transformation processes accounted for 56% of total nitrogen removal, which was significantly higher than that in other regions (12% on average; p < 0.01). Results and findings could provide useful information for the improvement of water environmental capacity.

9.
Polymers (Basel) ; 12(8)2020 Aug 05.
Artigo em Inglês | MEDLINE | ID: mdl-32764279

RESUMO

Expanded polystyrene (EPS) has excellent thermal insulation properties and is widely applied in building energy conservation. However, these thermal insulation materials have caused numerous fires because of flammability. Pyrolysis is necessary to support combustion, and more attention should be paid to the pyrolysis characteristics of EPS. Moreover, pyrolysis is considered to be an effective method for recycling solid waste. Pyrolysis kinetics of EPS were analyzed by thermogravimetric experiments, both in nitrogen and air atmospheres. A new method was proposed to couple the Flynn-Wall-Ozawa model-free method and the model-fitting method called the Coats-Redfern as well as the particle swarm optimization (PSO) global algorithm to establish reaction mechanisms and their corresponding kinetic parameters. It was found that the pyrolysis temperature of EPS was concentrated at 525-800 K. The activation energy of EPS in nitrogen was about 163 kJ/mol, which was higher than that in air (109.63 kJ/mol). Furthermore, coupled with Coats-Redfern method, reaction functions g(α) = 1 - (1 - α)3 and g(α) = 1 - (1 - α)1/4 should be responsible for nitrogen and air reactions, respectively. The PSO algorithm was applied to compute detailed pyrolysis kinetic parameters. Kinetic parameters could be used in further large-scale fire simulation and provide guidance for reactor design.

10.
Water Res ; 182: 116040, 2020 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-32622134

RESUMO

Hyporheic zones (HZ) are hotspots for biogeochemical reactions where groundwater and surface water mix. River dam buildings and other hydrologic controls alter the sediment grain size distribution and modify the downstream hyporheic exchange, with cascading effects on geochemical and microbial processes in river corridors. In this lab-scale column experiment, the N transformations in HZ filled with sediments in different grain sizes were investigated with a focus on understanding the interplay among variational hydraulic connectivity, microbial community structure, functional potential under frequent groundwater-surface water exchange. Porosity was identified as the main driver determining bacterial community assembly in HZ sediments. Significant microbial zonation was observed along the columns and the degree of co-occurrence of bacterial communities in the Fine column was lower than that in the Coarse and Mix columns. The Coarse column allowed for almost 2.47 times the exchange flux relative to the Fine column, and generates the fastest DO consumption rate (-6.52 µg O2/L·s). The enrichment of nitrifiers, i.e., Cytophagaceae and Bacillaceae and nitrification functional genes, i.e., amoA_AOA and amoA_AOB revealed the higher nitrification potential in column filled with coarse sediments. In comparison, the highest NH4+ production rates (2.4 × 10-3 µg N/L·s) took place in Fine column. The higher abundancies of denitrifiers such as Comamonadaceae and Lysobacter and enrichment of functional genes of nirK and nirS interestingly suggested the elevated denitrification potential in Fine column in a more anaerobic environment. The results implied that variations in microbial functional potential and associated nitrogen transformation may occur in size-fractioned HZ to dynamic hyporheic exchange, which added new knowledge to the underlying biogeochemical and ecological processes in regulated river corridors.


Assuntos
Água Subterrânea , Microbiota , Sedimentos Geológicos , Nitrificação , Nitrogênio , Rios
11.
Sci Rep ; 10(1): 12084, 2020 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-32669594

RESUMO

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

13.
Sci Rep ; 10(1): 9638, 2020 06 15.
Artigo em Inglês | MEDLINE | ID: mdl-32541650

RESUMO

Assistive wearable soft robotic systems have recently made a surge in the field of biomedical robotics, as soft materials allow safe and transparent interactions between the users and devices. A recent interest in the field of soft pneumatic actuators (SPAs) has been the introduction of a new class of actuators called fabric soft pneumatic actuators (FSPAs). These actuators exploit the unique capabilities of different woven and knit textiles, including zero initial stiffness, full collapsibility, high power-to-weight ratio, puncture resistant, and high stretchability. By using 2D manufacturing methods we are able to create actuators that can extend, contract, twist, bend, and perform a combination of these motions in 3D space. This paper presents a comprehensive simulation and design tool for various types of FSPAs using finite element method (FEM) models. The FEM models are developed and experimentally validated, in order to capture the complex non-linear behavior of individual actuators optimized for free displacement and blocked force, applicable for wearable assistive tasks.

14.
Dis Markers ; 2020: 9731854, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32454909

RESUMO

Background: Acute pancreatitis (AP) is a life-threatening disease caused by a variety of factors, and once it progresses to severe acute pancreatitis, the prognosis is poor. The purpose of this study was to investigate the diagnostic value of the neutrophil-lymphocyte ratio (NLR) for predicting the severity of acute pancreatitis. Materials and Methods: We searched the databases of PubMed, EMBASE, Web of Science, and Cochrane Library to identify eligible studies using the NLR to predict the severity of AP. The sensitivity (SEN), specificity (SPE), negative likelihood ratio (NLR), positive likelihood ratio (PLR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC) were combined using a bivariate mixed model. Results: A total of 10 articles containing 394 cases and 1319 controls were included in the study. The combined SEN, SPE, NLR, PLR, DOR, and AUC are 79% (73%-84%), 71% (59%-80%), 0.30 (0.21-0.41), 2.7 (1.8-4.0), 9 (5-18), and 0.82 (0.78-0.85), respectively. Conclusions: NLR has a moderately high diagnostic value in predicting the severity of acute pancreatitis.

15.
Environ Sci Pollut Res Int ; 27(24): 30706-30715, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32472504

RESUMO

This study investigates the transmission of volatility between OPEC-oil and sector stock returns in Pakistan. The issue of volatility spillovers across the oil and sector stocks is a crucial part of risk management and portfolio designs, as all firms are not expecting to be equally affected by changes in oil price. Empirically, we estimate a bivariate VAR-GARCH model using daily data sampled from January 1, 2003 to December 29, 2017. We also analyze the optimal weights and hedge ratios for oil-stock portfolio holdings based on our model results. Our findings reveal that negative and significant spillover effects from the oil market to agriculture, energy, and machinery sector stocks are present. However, our findings show that volatility spillover effects are insignificant from stock returns to oil. The findings of the study illustrate that development of stock market will motivate highly polluting firms to invest more in renewable and clean energy, which will help reduce carbon emissions.


Assuntos
Investimentos em Saúde , Paquistão , Volatilização
16.
Environ Pollut ; 264: 114671, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32375092

RESUMO

The combined contamination of brominated flame retardants (BFRs) and heavy metals in electronic waste (e-waste) recycling and disposal areas has been a serious concern owing to their environmental persistence and chronic toxicities. Ammonia oxidizers, e.g., ammonia-oxidizing archaea (AOA) and bacteria (AOB) play essential roles in nitrogen cycling and can serve as ideal indicators that reflect the changes in sediment health in response to environmental variables. There is currently very little information available on the combined toxic effects of BFRs and heavy metals on AOA and AOB communities. In this study, two typical e-waste pollutants, tetrabromobisphenol A (TBBPA) and copper (Cu), were selected as target contaminants to investigate the individual and combined effects of both pollutants on AOA and AOB communities in river sediments. Respective treatments of TBBPA (1, 10, and 20 mg/kg wet weight), Cu (100 mg/kg wet weight) and their combined treatments (weight ratios of 1:100, 1:10, and 1:5) were performed in laboratory experiments. High-throughput sequencing was applied to explore the response of ammonia oxidizers to TBBPA and Cu. The interaction types of TBBPA and Cu were calculated by the directional classification system to reveal the individual and combined toxicities of both contaminants to the ammonia oxidizers. On days 15 and 30, the dominant interaction type of TBBPA and Cu was synergistic (62.50%), and the combined contamination exacted selective pressure and inhibition on the AOB and AOA communities. On days 45 and 90, the interaction type shifted to be antagonistic (83.33%), with both the AOB and AOA communities gradually reaching stable population equilibria. The alteration of the interaction type is attributed to the elevated TBBPA/Cu tolerance as the incubation time increased. This study disclosed the interaction types of TBBPA and Cu in contaminated river sediments, and revealed that the combined effect could potentially manipulate AOB and AOA communities.


Assuntos
Amônia , Archaea , Bactérias , Cobre , Oxirredução , Filogenia , Bifenil Polibromatos , Rios , Microbiologia do Solo
17.
Artigo em Inglês | MEDLINE | ID: mdl-32380937

RESUMO

PRP is an autologous platelet concentrate prepared from the whole blood that is activated to release growth factors and cytokines and has been shown to have the potential capacity to reduce inflammation and improve tissue anabolism for regeneration.The use of platelet-rich plasma (PRP) provides a potential for repair due to its abundant growth factors and cytokines, which are key in initiating and modulating regenerative microenvironments for soft and hard tissues. Among outpatient, orthopedic injuries are common and include bone defects, ligament injury, enthesopathy, musculoskeletal injury, peripheral nerve injury, chronic nonhealing wounds, articular cartilage lesions and osteoarthritis, which are caused by trauma, sport-related or orther types of trauma or tumor resection. Surgical intervention is often required to treat these injuries. However, for numerous reasons regarding limited regeneration capacity and insufficient blood supply of the defect region, these treatments commonly result in unsatisfactory outcomes, and follow-up treatment is challenging. The aim of the present review is to explore future research in the field of PRP therapy in the treatment of diseases associated with orthopedic injuries.

18.
Dalton Trans ; 49(17): 5493-5502, 2020 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-32266911

RESUMO

Heat therapy is a promising therapeutic modality for cancer treatment due to the minimum adverse effects of selective local hyperthermia; however, the low heating efficiency of heat therapy under safe conditions is an issue for its bioapplication. Here, we report the synthesis of water-dispersible sulfur doped iron oxides (SDIOs) with different phase structures and the exploration of the relationships between the different SDIOs and their induction heating capacities as a guideline to obtain a photo-magnetic hyperthermia agent. The agent exhibits good biocompatibility, excellent photothermal conversion efficiency (55.8%) and great T2 weighted magnetic resonance imaging (63.7 mM-1 s-1). Significantly, the SDIOs effectively eliminate tumours in a biologically safe AC magnetic field range (H·f = 4.3 < 5.0 × 106 kA m-1 s-1) and with 808 nm laser irradiation at a safe density of 0.33 W cm-2; also, they can be mostly metabolized from the body after one month. The work presented here adopts anion-doped iron oxides to dramatically improve photo-magnetic hyperthermia effects and may enable further exploration in thermotherapeutic research.

19.
Environ Res ; 186: 109498, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32289568

RESUMO

Phosphorus, one of the primary limiting factors for eutrophication, plays a crucial role in the ecology health of aquatic ecosystems. However, understanding phosphorus bioavailability and source contributions in contaminated lake sediments which could help develop effective eutrophication management plans is limited largely due to the lack of appropriate methods in large catchments with a complex arrangement of sources. Based on the significant relationships between sediment, phosphorus and microbial community, source-specific microbial community fingerprints formed by machine-learning classification SourceTracker might shed light on determining dominant phosphorus sources in the river-lake systems in the era of high-throughput sequencing. This study was conducted in Dongting Lake that suffered accelerated eutrophication due to considerable phosphorus input from the inflow-rivers. The results of phosphorus fractionation according to the Standards, Measurements and Testing harmonized procedure indicated that sediments in the central lake had a higher concentration of non-apatite inorganic phosphorus (Mann-Whitney U test), which deserves greater attention on the risk of phosphorus release. The significant relationships between phosphorus fractionations, sediment and bacterial community were established with the spearman correlation and network analysis. SourceTracker analysis indicated that the major inflow-rivers of phosphorus sources to Dongting Lake were the Songzi, Miluo, and Xinqiang Rivers. The effects of sediment diffusion distance on phosphorus source apportionment were further confirmed. Taken together, our results contribute to an improved understanding of phosphorus fractionations and source contributions in the river-lake systems and its potential impact to eutrophication management plans.

20.
Bioresour Technol ; 306: 123187, 2020 Mar 14.
Artigo em Inglês | MEDLINE | ID: mdl-32213451

RESUMO

Understanding the underlying mechanism that drives the microbial community mediated by graphene derivative is crucial for achieving the enhancement of biological nitrogen removal by external stimulation. The main objectives of this study were to identify the bacterial community assembly mechanism via null model test and molecular ecological network analysis in the sediment culture system. Results showed graphene derivative increased biological nitrogen removal efficiency by 125%. The high electron transfer efficiency and denitrifying enzyme activities were achieved. Deterministic assembly is dominate (>90%) in all the community assembly while the stochastic assembly process only existed in graphene derivative system (6.67%). The nitrogen removal was enhanced due to the intensification of the interaction on the microbial community between stochastic assembly and deterministic assembly. Keystone taxa in the graphene derivative systems, including Sulfuricella, Rhodobacter, and Comamonadaceae, drove the alteration of community structure relating to the nitrogen removal.

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