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1.
Zhonghua Liu Xing Bing Xue Za Zhi ; 41(4): 489-493, 2020 Mar 05.
Artigo em Chinês | MEDLINE | ID: mdl-32133830

RESUMO

Objective: To describe the epidemiological characteristics of a cluster of COVID-19 cases reported in Baodi district of Tianjin as of 18 February, 2020, which might be associated with the exposure in a local department store, and provide suggestions for prevention and control strategy development. Methods: The basic characteristics, time and area distributions, clinical manifestations, epidemiological history and transmission mode of the COVID-19 cases associated with the department store exposure were analyzed. Results: A total of 40 COVID-19 cases were associated with the department store exposure, accounting for 75.47% of the total confirmed cases (53 cases) reported in Baodi district. The cases were mainly at the age of 60 years or older (35.00%) and farmers (40.00%). The main clinical manifestations included fever (95.00%), cough (35.00%), and diarrhea (15.00%). The proportion of confirmed severe cases was 32.50%. The incidence curve showed that the incidence peak occurred on 31 January, 2020. Among the 40 cases, 6(15.00%) were department store employees, 19(47.50%) were customers and 15(37.50%) were close contacts (secondary cases). The first case occurred on 21 January, 2020, this case was a department store employee who had a purchasing history at whole sale markets in other provinces and cities before the onset, and 3 employees were still on duty after symptom onsets. The median of the incubation period of customer cases was 6 days, and the median of the interval between onset and medical treatment of customer cases was 7 days. Conclusion: This was a cluster epidemic of COVID-19, which might be associated with the exposure in the department store. By now, the current prevention and control measures have achieved satisfied effects.

2.
Artigo em Chinês | MEDLINE | ID: mdl-32062895

RESUMO

Objective: To analyze the major occupational disease surveillance and the occupational health examination of Jining in 2018, provide the basis for the government department formulating occupational disease prevention measures. Methods: In January 2019, collecting data of the occupational disease and Occupational Health Information Surveillance Network in Jining from January 1 to December 31, 2018, 37295 workers were collected, and 37295 workers who were exposed to key occupational disease risk factors and underwent occupational health check-up during their working period. The contact of occupational Hazard Factors and occupational health examination were analyzed. SPSS 22.0 was used to set up the database for statistical analysis. Results: Workers exposed to major occupational hazards were more exposed to noise (56.34%, 39935/70883) , coal dust (15.65%, 11095/70883) , welding fume (10.25%, 7262/70883) , silicon dust (5.61%, 3975/70883) . In 2018, 24 cases (38.71%, 2462) of coal worker's pneumoconiosis, 21 cases (33.87%, 2162) of silicosis, 8 cases (12.90%, 82) of noise deafness and 8 cases (12.90%, 862) of brucellosis were the major occupational diseases reported. The abnormal rate of lung function examination was 14.87% (461/3100) , and the abnormal rate of high frequency hearing threshold examination was 4.56% (1492/32731) in workers exposed to coal dust (coal-silica dust) , the difference was statistically significant (P<0.01) . Conclusion: Jining should strengthen the supervision of enterprises with key occupational disease hazards, formulate classified supervision and management methods, and improve the occupational health inspection rate of workers.


Assuntos
Doenças Profissionais/epidemiologia , Exposição Ocupacional/análise , Saúde do Trabalhador , China , Nível de Saúde , Humanos
3.
Clin Radiol ; 74(12): 976.e1-976.e9, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31604574

RESUMO

AIM: To develop liver a computed tomography (CT) radiomics model to predict gastro-oesophageal variceal bleeding (GVB) secondary to hepatitis B-related cirrhosis. MATERIALS AND METHODS: Electronic medical records and image data of liver triple-phase contrast-enhanced CT examinations of 295 patients with hepatitis B-related cirrhosis were collected retrospectively from two hospitals. Two hundred and thirty-six and 59 patients were enrolled randomly into the training and validation cohorts, respectively; and 75 in the training cohort and 16 in the validation cohort endured GVB while the others did not during follow-up period. Radiomics features of the liver were extracted from the portal venous phase images, and clinical features came from medical records. The tree-based method and univariate feature selection were used to select useful features. The radiomics model, clinical model, and integration of radiomics and clinical models were built using the useful image features and/or clinical features. Predicting performance of three models was evaluated with the area under receiver-operating characteristic curve (AUC), accuracy, and F-1 score. RESULTS: Twenty-one useful radiomics features and/or three clinical features were selected to build prediction models that correlated with GVB. AUC of integration of radiomics and clinical models was larger than of clinical or radiomics models for the training cohort (0.83±0.09 versus 0.64±0.08 or 0.82±0.10) and the validation cohort (0.64 versus 0.61 or 0.61). Integration of radiomics and clinical models obtained good performance in predicting GVB for both the training and validation cohorts (accuracy: 0.76±0.07 and 0.73, and F-1 score: 0.77±0.09 and 0.72, respectively). CONCLUSION: Integration of the radiomics and clinical models may be a non-invasive method to predict GVB.

4.
Neoplasma ; 66(5): 847-857, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31288527

RESUMO

The aim of this work was to determine the expression of the ERß (estrogen receptor ß) and multidrug resistance, namely MDR1 (P-glycoprotein, P-gp), in 152 samples of non-small cell lung cancer. The expression pattern of ERß and MDR1 were assessed by the quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry. We also analyzed the correlation between ERß and MDR1 with clinical and pathological data. The co-expression pattern of ERß and individual MDR1 proteins was assessed by correspondence analysis and chi-squared tests. In the present study, we found that patients with tumor stage I-II showed higher ERß mRNA expression levels and decreased expression of ERß protein with increasing tumor grade, which is opposite to MDR1 expression. In addition, an opposite co-expression pattern of ERß and individual MDR1 proteins was also observed. In conclusion, the results can be used to better understand the expression control of MDR1 and may allow for the establishment of new cancer chemistry strategies that will control P-gp expression in NSCLC.


Assuntos
Carcinoma Pulmonar de Células não Pequenas/metabolismo , Resistência a Múltiplos Medicamentos , Resistencia a Medicamentos Antineoplásicos , Receptor beta de Estrogênio/metabolismo , Neoplasias Pulmonares/metabolismo , Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo , Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Estadiamento de Neoplasias , Reação em Cadeia da Polimerase Via Transcriptase Reversa
5.
IUCrJ ; 6(Pt 4): 552-557, 2019 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-31316800

RESUMO

A Cr3Al compound with a DO3 structure has previously been predicted to be nearly half metal and a promising spintronics material; however, its synthesis has not been reported. Here, a Cr3Al compound with a DO3 structure is successfully prepared in thin-film form by the magnetron sputtering method. It was found that the substrate temperature is crucial to the atomic ordering, thin-film density and lattice constant. The lattice constant varies with different substrate temperatures and is smaller than the theoretical equilibrium lattice constant. Theoretical investigations on the electronic structures and magnetic properties indicate that the Cr3Al compound with a DO3 structure is a rare material with zero-gap half-metallic characteristics under an experimental lattice constant of 5.83 Å. The experimental result is in agreement with the theoretical results in magnetization, and the Cr3Al compound synthesized in this work exhibits semi-metallic-like electrical transport characteristics and positive magnetoresistance of greater than 2% in the temperature range 2-250 K.

6.
IUCrJ ; 6(Pt 4): 688-694, 2019 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-31316812

RESUMO

CsCl-type materials have many outstanding characteristics, i.e. simple in structure, ease of synthesis and good stability at room temperature, thus are an excellent choice for designing functional materials. Using high-throughput first-principles calculations, a large number of topological semimetals/metals (TMs) were designed from CsCl-type materials found in crystallographic databases and their crystal and electronic structures have been studied. The CsCl-type TMs in this work show rich topological character, ranging from triple nodal points, type-I nodal lines and critical-type nodal lines, to hybrid nodal lines. The TMs identified show clean topological band structures near the Fermi level, which are suitable for experimental investigations and future applications. This work provides a rich data set of TMs with a CsCl-type structure.

7.
Eur Rev Med Pharmacol Sci ; 23(11): 4961-4970, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31210332

RESUMO

OBJECTIVE: To investigate the potential influence of micro ribonucleic acid (miR)-9 on depressive behaviors of depression mice. MATERIALS AND METHODS: Depression model in mice was established via chronic unpredictable mild stress. A total of 36 C57BL/6 mice were randomly divided into control group (control mice, n=12), model group (depression mice administrated with control lentivirus, n=12) and miR-9 low-expression group (depression mice administrated with LV-miR-9-shRNA lentivirus, n=12). After 6 weeks, the depressive behaviors of mice were evaluated by behavioral experiments. Mice were then sacrificed for harvesting the hippocampus. Relative level of miR-9 in mouse hippocampus was determined via quantitative polymerase chain reaction (qPCR). Moreover, the number of newborn neurons in the hippocampus in each group was detected via immunofluorescence assay. Expression levels of doublecortin (DCX), post-synaptic density protein 95 (PSD95) and Notch signaling pathway in the hippocampus in each group were detected via Western blotting. RESULTS: In the open field test, there were no significant differences in the crossing score and rearing score among control group, model group and miR-9 low-expression group (p>0.05). The immobility time of mice in tail suspension test and forced swimming test increased significantly in model group compared with that in control group (p<0.01), while it was significantly shorter in miR-9 low-expression group than that in model group (p<0.01). The expression of miR-9 in mouse hippocampus in model group was significantly higher than that in control group and miR-9 low-expression group (p<0.01). In miR-9 low-expression group, the number of newborn neurons in the hippocampus was significantly larger than that in control group and model group (p<0.01). Protein levels of both DCX and PSD95 were significantly higher in control group than those in model group (p<0.01). Besides, protein levels of Notch intracellular domain (NICD), Hes1 and Jag1 in the hippocampus in model group were remarkably declined compared with those in control group (p<0.01), which were higher in miR-9 low-expression group. CONCLUSIONS: MiR-9 is upregulated in the hippocampus of depression mice. Silence of miR-9 in the hippocampus can effectively activate the Notch signaling pathway, promote the neuronal regeneration in the hippocampus and improve the depressive symptoms of mice.

8.
Neoplasma ; 66(5): 810-817, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31129969

RESUMO

The American Joint Committee on Cancer (AJCC) released its 8th edition of cancer staging implemented in early 2018. This study aims to compare anatomic staging (AS) with prognostic staging (PS) based on the updated AJCC 8th edition staging manual. A retrospective single-center analysis of 313 triple-negative breast invasive ductal carcinoma patients who received surgery at department of breast surgery in the Fourth Hospital of Hebei Medical University from 01/2010 -12/2012 was performed. All cases were restaged using the AJCC 8th edition AS and PS system. The 7-year disease-free survival (DFS) and the 7-year overall survival (OS) rates were 76.30% and 78.27%, respectively. Applying the PS system, 277 (88.5%) patients of the AS groups were upstaged to the PS groups, 31 cases with IIIC and 5 cases with IV unchanged (11.5%) and no cases downstaged. Both 7-year DFS and 7-year OS were significantly different in the different AS and PS groups (all, p<0.001). The PS system was found to provide better prognostic information in patients with AS group IIB. A total of 43 patients with AS group IIB were upstaged by PS system, in which 30 patients were +2 upstaged to PS IIIB, and 13 patients were +3 upstaged to PS IIIC. PS IIIB and IIIC from AS IIB had significant differences in 7-year DFS (χ2=5.628, p=0.014) and 7-year OS (χ2=6.037, p=0.018). Both AS and PS systems proposed in the 8th edition of the AJCC breast cancer staging manual had prognostic value in TNBC. Moreover, the PS system predicts clinical outcomes of TNBC patients more accurately than the traditional AS system.


Assuntos
Carcinoma Ductal de Mama/diagnóstico , Estadiamento de Neoplasias , Neoplasias de Mama Triplo Negativas/diagnóstico , Intervalo Livre de Doença , Humanos , Prognóstico , Estudos Retrospectivos , Estados Unidos
9.
Neoplasma ; 20192019 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-31088107

RESUMO

The American Joint Committee on Cancer (AJCC) released its 8th edition of cancer staging which is to be implemented in early 2018. This study aims to compare anatomic staging (AS) with prognostic staging (PS) based on the updated AJCC 8th edition staging manual. A retrospective single-center analysis of 313 triple-negative breast invasive ductal carcinoma patients who received surgery at department of breast surgery in the Fourth Hospital of Hebei Medical University from 2010-01 to 2012-12 was performed. All cases were restaged using the AJCC 8th edition AS and PS system. The 7-year DFS and the 7-year OS rates were 76.30% and 78.27%, respectively. Applying the PS system, 277 (88.5%) patients of the AS groups were up-staged to the PS groups, 31 cases with IIIC and 5 cases with IV unchanged (11.5%), and no cases down-staged. Both 7-year DFS and 7-year OS were significantly different in the different AS and PS groups (all, P<0.001). The PS system was found to provide better prognostic information in patients with AS group IIB. A total of 43 patients with AS group IIB were up-staged by PS system, in which 30 patients were +2 up-staged to PS IIIB, and 13 patients were +3 up-staged to PS IIIC. PS IIIB and IIIC from AS IIB had significant differences in 7­year DFS (χ2 = 5.628, P = 0.014) and 7­year OS (χ2 = 6.037, P = 0.018). Both AS and PS systems proposed in the 8th edition of the AJCC breast cancer staging manual had prognostic value in TNBC. Moreover, the PS system predicts clinical outcomes of TNBC patients more accurately than the traditional AS system.


Assuntos
Estadiamento de Neoplasias/métodos , Neoplasias de Mama Triplo Negativas/diagnóstico , Feminino , Humanos , Prognóstico , Estudos Retrospectivos , Estados Unidos
11.
Artigo em Chinês | MEDLINE | ID: mdl-30970400

RESUMO

Objective:This study was designed to show the preliminary efficacy and safety of the improved tongue base suspension surgery in severe obstructive sleep apnea(OSA) patients classified as Friedman Ⅱand Friedman Ⅲ. Method:The severe OSA patients diagnosed by PSG as Friedman Ⅱ type and Ⅲ type underwent surgery treatment. The tongue base of the patient was implanted with titanium plate and fixed on the chin of mandible. The UPPP surgery was performed with reference to H-UPPP. After surgery, the patients were followed up, PSG was re-examined and the change of various subjective and objective indicators of rehabilitation and adverse reactions were observed and recorded.Result: One hundred and two patients with severe OSA who were not tolerant or unwilling to use CPAP treatment were treated by the above surgical method. All the patients underwent surgery successfully and generally recovered about 1 month after the surgery without obvious tongue base pain, foreign body sensation or other discomfort. Eating and speaking function were as usual, the wound was healed well, and no serious infection or rejection was observed. The main postoperative adverse reactionwas tension line fracture(3 cases). Sixty-seven patients completed follow-up. At 3 to 6 months after surgery, the AHI, ESS sleepiness score and snore index were lower than those before surgery, while LSaO2and CT 90% were higher than those before surgery(P<0.01). The AHI before surgery was 60.5± 22.4, and the average AHI after surgery was 27.8± 22.4. The effective rate of the surgery was 71.6% and the success rate was 58.2%. The AHI has dropped by an average of 54.0%, and snore improved by 63.9%. Conclusion: After preliminary clinical observation, the study suggests that the improved tongue base suspension with UPPP has satisfactory curative effect and feasibility for the treatment of severe OSA patients classified as Friedman Ⅱ type and Ⅲ type.


Assuntos
Apneia Obstrutiva do Sono , Língua , Humanos , Faringe , Polissonografia , Apneia Obstrutiva do Sono/cirurgia , Ronco , Língua/cirurgia , Resultado do Tratamento , Úvula
12.
Zhonghua Yi Shi Za Zhi ; 49(1): 29-33, 2019 Jan 28.
Artigo em Chinês | MEDLINE | ID: mdl-30970422

RESUMO

Shanghan Lun Ben Zhi(, Essential intention of Treatise on Febrile Diseases Caused by Cold) have many versions: the edition of Yanshan bookstore was published in the 16th year of Daoguang (1836); the edition of Juwentang was published during the Tongzhi period; the lithographic printing of Licheng Sanyou Yizhai was published in the 1st year of Xuantong (1909); the Qiu Jisheng's edition was published in the 8th year of the Republic of China (1919); the lithographic printing of Shaoxing Moruntang book court was published in the 18th year of the Republic of China (1929); the photocopy of lithographic printing of Licheng Sanyou Yizhai in the 1st year of Xuantong (1909) was published by Taiwan Freedom Press in 1973; the photocopy of Juwentang's edition during the Tongzhi period was published through Xuxiu Siku Quanshu(, Continuation of Complete Library of Four Branches of Literature) by Shanghai Ancient Books Publishing House in 2002; the photocopy of Tongzhi's edition was published through Zhongyi Guji Zhenben Jicheng (, Integration of Ancient Books of Traditional Chinese Medicine: continued) by Hunan Science and Technology Publishing House in 2014; the point collation edition of Xuxiu Siku Quanshu Shanghan Lei Yizhu Jicheng(, Continuation of the Integration of Typhoid Medical Works in Complete Library of Four Branches of Books) was published by Jiangsu Science and Technology Press in 2010. The description of Sibu Zonglu Yiyao Bian(, Four general catalogues medical editorial) was recorded in Daoguang's 16th year (1836) of Yanshan bookstore as "the edition of Qing Daoguang's 15th year Yiwei" ; in addition, Zhongguo Zhongyi Guji Zongmu(, Chinese traditional medicine ancient books general catalogue) was recorded in Daoguang's 16th year (1836) of Yanshan bookstore as "the Yanshan bookstore engraved edition in Qingdaoguang's 15th year Yiwei (1835)" , but they were both errors. The photocopy Tongzhi edition of Xuxiu Siku Quanshu was mistakenly entitled "edition of Qing Daoguang Lithography of Yanshan Bookstore Print" . The description of Shanghan Lun Ben Zhi in Zhongguo Zhongyi Guji Zongmu had the edition of Qing Daoguang's 9th year Jichou (1829) and the edition of Guangdong Dasheng pharmaceutical bureau of the Republic of China.


Assuntos
Livros , Medicina Tradicional Chinesa , China , História do Século XX , Medicina Tradicional Chinesa/história , Pesquisa , Taiwan
13.
Beijing Da Xue Xue Bao Yi Xue Ban ; 51(2): 362-364, 2019 Apr 18.
Artigo em Chinês | MEDLINE | ID: mdl-30996384

RESUMO

Peripheral arterial disease is one part of systematic atherosclerosis, becoming a heavy burden of human health. Patients in end stage of peripheral arterial disease manifest critical limb ischemia with severe rest pain and refractory ulcer. Surgical revascularization is the optimal option for patients with critical limb ischemia to avoid major amputation and improve quality of life. However, some of them contraindicate surgical revascularizations owing to coexisting morbidities. Spinal cord stimulation is reported to be effective and minimally invasive in pain relief and limb salvage for patients with limb ischemia. Here, we reported one case with chronic critical limb ischemia and gangrene of foot who underwent spinal cord stimulation, which was, as we knew, the first case in China. He was diagnosed with Burger disease and accompanied with history of stroke, chronic obstructive pulmonary disease and Castleman's disease. It showed totally occlusive lesions of external iliac and femoropopliteal artery and no outflows below the knee in the computed tomography angiography. Given the complexity of lesions and weakness of the patient, spinal cord stimulation was indicated for control of rest pain and limb salvage. As specified, we implanted the temporary neurostimulator as the first step. After 2 weeks from temporary neurostimulator implantation, the patient achieved significant relief in intensity of pain, and acquired 20% improvement of transcutaneous oxygen pressure. The satisfactory results indicated probable effectiveness of spinal cord stimulation, thus we performed the permanent neurostimulator implantation 1 month later. During 2 months of follow-up, the patients stabilized at Fountain III with pain relief with one kind of nonsteroidal anti-inflammatory drug. In our case, we confirmed the significant validity of spinal cord stimulation for pain control and consequent improvement of quality of life in non-reconstructable chronic critical limb ischemia. Furthermore, we reviewed that a number of published studies suggested that spinal cord stimulation be a reasonable option for patients with critical rest pain, especially who contraindicated surgical revascularization. The application of spinal cord stimulation in pain relief for non-reconstructable chronic critical limb ischemia was approved by related guidelines released by European Society of Cardiology and Trans-Atlantic Inter-Society Consensus. Further investigations are required for assessing the long-term outcome in limb salvage.


Assuntos
Estimulação da Medula Espinal , China , Humanos , Isquemia , Perna (Membro) , Salvamento de Membro , Masculino , Qualidade de Vida , Medula Espinal , Resultado do Tratamento
14.
Zhonghua Shao Shang Za Zhi ; 35(3): 224-227, 2019 Mar 20.
Artigo em Chinês | MEDLINE | ID: mdl-30897871

RESUMO

On 17th June 2017, a 50 years old man with refractory gout was admitted in our hospital. During the treatment, he was accompanied by intermittent fever (39 to 40 ℃) of unknown origin for 60 days and gastrointestinal bleeding, with difficult wound repair. After comprehensive treatment of thorough debridement, vacuum sealing drainage, skin graft, skin flap repair, and drug administration, the patient was discharged fully recovered on post hospitalization day 104.


Assuntos
Febre/complicações , Hemorragia Gastrointestinal/complicações , Gota/terapia , Desbridamento , Drenagem , Gota/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Tratamento de Ferimentos com Pressão Negativa , Transplante de Pele , Resultado do Tratamento , Cicatrização
15.
Zhonghua Yu Fang Yi Xue Za Zhi ; 53(3): 272-278, 2019 Mar 06.
Artigo em Chinês | MEDLINE | ID: mdl-30841666

RESUMO

Objective: To explore the relationship between anthropometric indices and the incident risk of hypertension, compare novel anthropometric indices with traditional indices in hypertension prediction and establish hypertension prediction models among elderly Chinese. Methods: A total of 27 009 retirees from the Dongfeng Motor Corporation were recruited at baseline in 2008 and the first follow-up was conducted in 2013. After the exclusion of participants less than 60 years old, participants with hypertension, coronary heart disease, stroke, cancer, and those with missing data, a total of 6 784 elderly participants were enrolled in this study. A multivariate logistic regression model was used to analyze the relationship between traditional anthropometric indices, body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), novel anthropometric indices, visceral adiposity index (VAI), body shape index (ABSI), body roundness index (BRI), and the incident risk of hypertension. Meanwhile, a multivariate logistic regression model was used to establish hypertension prediction models. Receiver operating characteristic (ROC) curve was applied to compare the prediction ability of different models. Results: A total of 1 787 incident cases of hypertension were identified, with the incidence of hypertension about 27.59%. Significant positive associations were detected between BMI, WC, WHtR, VAI, BRI and the incident risk of hypertension after adjusting for potential confounders (all P values<0.05). In men, the OR (95%CI) (upper tertile vs lower tertile) was 1.45 (1.22-1.73) for VAI, and 1.86 (1.55-2.23) for BRI. In women, the OR (95% CI) (upper tertile vs lower tertile) was 1.55 (1.22-1.96) for VAI, and 1.60 (1.27-2.01) for BRI. For ABSI, no significant association was observed in either men (OR (95%CI): 1.07 (0.90-1.28)) or women (OR (95%CI): 1.03 (0.82-1.29), both P values >0.05). The basic hypertension prediction model included age, drinking (only in men), education status (only in men), systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting blood glucose levels. Based on the basic prediction model, BMI (in men: AUC=0.697) and BRI (only in men: AUC=0.696) improved area under ROC curve (AUC) significantly (P<0.05). BMI was the strongest predictor in both men (AUC=0.697) and women (AUC=0.685) in the extended model. Conclusion: Significant positive associations were detected between BMI, WC, WHtR, VAI, BRI and the incident risk of hypertension among elderly Chinese. BMI was the strongest predictor in hypertension prediction model compared with other anthropometric indices.


Assuntos
Antropometria/métodos , Hipertensão/epidemiologia , Idoso , Índice de Massa Corporal , China/epidemiologia , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Fatores de Risco
16.
Br J Anaesth ; 122(3): 350-360, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30770053

RESUMO

BACKGROUND: Resolution of inflammation is an active and dynamic process after surgery. Maresin 1 (MaR1) is one of a growing number of specialised pro-resolving lipids biosynthesised by macrophages that regulates acute inflammation. We investigated the effects of MaR1 on postoperative neuroinflammation, macrophage activity, and cognitive function in mice. METHODS: Adult male C57BL/6 (n=111) and Ccr2RFP/+Cx3cr1GFP/+ (n=54) mice were treated with MaR1 before undergoing anaesthesia and orthopaedic surgery. Systemic inflammatory changes, bone healing, neuroinflammation, and cognition were assessed at different time points. MaR1 protective effects were also evaluated using bone marrow derived macrophage cultures. RESULTS: MaR1 exerted potent systemic anti-inflammatory effects without impairing fracture healing. Prophylaxis with MaR1 prevented surgery-induced glial activation and opening of the blood-brain barrier. In Ccr2RFP/+Cx3cr1GFP/+ mice, fewer infiltrating macrophages were detected in the hippocampus after surgery with MaR1 prophylaxis, which resulted in improved memory function. MaR1 treatment also reduced expression of pro-inflammatory cell surface markers and cytokines by in vitro cultured macrophages. MaR1 was detectable in the cerebrospinal fluid of older adults before and after surgery. CONCLUSIONS: MaR1 exerts distinct anti-inflammatory and pro-resolving effects through regulation of macrophage infiltration, NF-κB signalling, and cytokine release after surgery. Future studies on the use of pro-resolving lipid mediators may inform novel approaches to treat neuroinflammation and postoperative neurocognitive disorders.


Assuntos
Encefalopatias/prevenção & controle , Ácidos Docosa-Hexaenoicos/farmacologia , Fraturas Ósseas/cirurgia , Inflamação/prevenção & controle , Transtornos Neurocognitivos/prevenção & controle , Idoso , Idoso de 80 Anos ou mais , Animais , Modelos Animais de Doenças , Feminino , Humanos , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Pessoa de Meia-Idade , Período Perioperatório
17.
Zhonghua Yi Xue Za Zhi ; 99(2): 120-123, 2019 Jan 08.
Artigo em Chinês | MEDLINE | ID: mdl-30669750

RESUMO

Objective: To analyze the influence of different thyroid stimulating hormone (TSH) cut-offs to diagnose subclinical hypothyroidism (SCH) in the first trimester of gestation. Methods: A total of 896 pregnant women were enrolled in Peking University International Hospital between October 2016 and March 2018. Among them, 421 pregnant women with single fetus who were conformed to the criteria of National Academy of Clinical Biochemistry (NACB), without adverse pregnancy outcomes and obstetric complications, were selected to establish their self-sequential longitudinal reference ranges of thyroid function. Then, SCH was diagnosed in the first trimester, using different TSH cutoffs, such as the upper limit of the first trimester-specific reference range, 4.0 mU/L recommended by the 2017 Guidelines of American Thyroid Association (ATA), 5.17 mU/L (Roche reagent) recommended by 2012 Guidelines of Chinese Society of Endocrinology and Chinese Society of Perinatal Medicine, and 2.5 mU/L recommended by 2011 Guidelines of ATA, respectively. Results: The TSH reference range was 0.12-4.16 mU/L in the first trimester. Using TSH>4.16, 4.0, 5.17 and 2.5 mU/L to diagnose SCH in the first trimester, the prevalence rates were 4.35% (39/896), 5.92% (53/896), 1.56% (14/896) and 20.87% (187/896), respectively. There was no statistically significant difference between the prevalence rates of SCH using the TSH upper reference limit of 4.0 mU/L and 4.16 mU/L (P=0.134). When TSH was defined as>4.0 mU/L to diagnose SCH, the sensitivity, specificity and Youden index was 97.4%, 98.2%, and 0.956, respectively. Conclusions: The TSH upper reference limit of 4.0 mU/L recommended by 2017 Guidelines of ATA can be used as a cut-off to diagnose SCH in first trimester for the areas without trimester-specific reference ranges for TSH in China.


Assuntos
Hipotireoidismo , Primeiro Trimestre da Gravidez , China , Feminino , Humanos , Gravidez , Testes de Função Tireóidea , Tireotropina
18.
Zhonghua Yi Xue Za Zhi ; 99(2): 142-147, 2019 Jan 08.
Artigo em Chinês | MEDLINE | ID: mdl-30669754

RESUMO

Objective: To construct computational fluid model of type B aortic dissection using patient-specific reverse engineering and fluid-structure interaction, and evaluate the application of computational fluid model on aortic remodeling of type B aortic dissection. Methods: Consecutive computed tomographic angiograph data was acquired from a patient with type B aortic dissection at initial diagnosis, 1 week and 6 years after endovascular repair of primary tear entry and 3 months after endovascular repair of distal tear erosion. Three-dimensional model of aortic dissection was reversely reconstructed by Mimics, and then the model was smoothened by Geomagic. Computational fluid dynamic numerical simulation was performed in ANSYS by the means of two-way fluid-structure interaction, and the relation between blood dynamic characteristic and thrombosed remodeling of type B aortic dissection was evaluated. Results: The computational fluid model of type B aortic dissection using patient-specific reverse engineering and fluid-structure interaction method was successfully constructed. Local peak of blood pressure on the convex surface of junction at aortic arch and descending aorta was found. The wall stress was much higher at the false lumen than that at the true lumen, and the peak of wall stress converged on the edge and tear entry of false lumen. After the exclusion of proximal tear entry, the blood streamline was decreased significantly and flowed reversely. Blood flow in the remaining false lumen was retrograded from the entry at left iliac artery and formed turbulence at the top of false lumen, which was benefit for dissection thrombus remodeling. The higher pressure at the false lumen was associated with the new formation of aortic aneurysm at the distal tear. Conclusion: The computational fluid model of aortic dissection based on patient-specific reverse engineering and fluid-structure interaction method can successfully reveal the relatively truly blood dynamic and wall pressure characteristic of type B aortic dissection.


Assuntos
Aneurisma Dissecante , Modelos Cardiovasculares , Aorta , Aneurisma Aórtico , Aneurisma da Aorta Torácica , Implante de Prótese Vascular , Procedimentos Endovasculares , Hemodinâmica , Humanos , Resultado do Tratamento
19.
Nutr Metab Cardiovasc Dis ; 29(3): 260-267, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30642789

RESUMO

BACKGROUND AND AIMS: We evaluated the association between parental obesity and their children's obesity parameters [e.g., percentage of body fat (PBF)] over time. METHODS AND RESULTS: The study included 2066 Chinese parents-children trios (n = 1001 girls and 1065 boys, aged 6-14 years). Children's height, weight, waist circumference (WC) and PBF (bioelectrical impedance analysis) were annually assessed from 2014 (baseline) to 2016. Information on parental height and body weight, and children's diet and physical activity was collected in 2014. The association between parental obesity and changes in their children's PBF during follow-up was analyzed using a mixed effects model. We also examined changes in children's BMI and WC in secondary analyses. Baseline mean BMI, WC, and PBF for children were 17.6 ± 3.5 kg/m2, 60.5 ± 9.6 cm, and 16.6 ± 6.5%, respectively. We observed that maternal, but not paternal, obesity was associated with a greater increase in children's PBF during the follow-up. An adjusted mean difference in annual increase of PBF was 0.41% [95% confidence interval (CI): 0.01%, 0.84%] for children with obese mothers, compared with those with normal-weight mothers. Both maternal and paternal obesity was associated with a greater increase in their children's BMI and WC (p trend<0.01 for both); however, the associations were stronger in mother-children pairs than those in father-children pairs. CONCLUSIONS: Maternal obesity was associated with a greater increase in PBF in Chinese school-aged children.


Assuntos
Filho de Pais Incapacitados , Mães , Obesidade/epidemiologia , Obesidade Pediátrica/epidemiologia , Adiposidade , Adolescente , Fatores Etários , Índice de Massa Corporal , Criança , China/epidemiologia , Impedância Elétrica , Pai , Feminino , Humanos , Estilo de Vida , Masculino , Obesidade/diagnóstico , Obesidade/fisiopatologia , Obesidade Pediátrica/diagnóstico , Obesidade Pediátrica/fisiopatologia , Prevalência , Fatores de Risco , Fatores Sexuais , Fatores de Tempo , Circunferência da Cintura
20.
Animal ; 13(3): 533-541, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29983136

RESUMO

Recent studies indicate that early postnatal period is a critical window for gut microbiota manipulation to optimise the immunity and body growth. This study investigated the effects of maternal faecal microbiota orally administered to neonatal piglets after birth on growth performance, selected microbial populations, intestinal permeability and the development of intestinal mucosal immune system. In total, 12 litters of crossbred newborn piglets were selected in this study. Litter size was standardised to 10 piglets. On day 1, 10 piglets in each litter were randomly allotted to the faecal microbiota transplantation (FMT) and control groups. Piglets in the FMT group were orally administrated with 2ml faecal suspension of their nursing sow per day from the age of 1 to 3 days; piglets in the control group were treated with the same dose of a placebo (0.1M potassium phosphate buffer containing 10% glycerol (vol/vol)) inoculant. The experiment lasted 21 days. On days 7, 14 and 21, plasma and faecal samples were collected for the analysis of growth-related hormones and cytokines in plasma and lipocalin-2, secretory immunoglobulin A (sIgA), selected microbiota and short-chain fatty acids (SCFAs) in faeces. Faecal microbiota transplantation increased the average daily gain of piglets during week 3 and the whole experiment period. Compared with the control group, the FMT group had increased concentrations of plasma growth hormone and IGF-1 on days 14 and 21. Faecal microbiota transplantation also reduced the incidence of diarrhoea during weeks 1 and 3 and plasma concentrations of zonulin, endotoxin and diamine oxidase activities in piglets on days 7 and 14. The populations of Lactobacillus spp. and Faecalibacterium prausnitzii and the concentrations of faecal and plasma acetate, butyrate and total SCFAs in FMT group were higher than those in the control group on day 21. Moreover, the FMT piglets have higher concentrations of plasma transforming growth factor-ß and immunoglobulin G, and faecal sIgA than the control piglets on day 21. These findings indicate that early intervention with maternal faecal microbiota improves growth performance, decreases intestinal permeability, stimulates sIgA secretion, and modulates gut microbiota composition and metabolism in suckling piglets.


Assuntos
Transplante de Microbiota Fecal/veterinária , Microbioma Gastrointestinal , Intestinos/fisiologia , Sus scrofa/microbiologia , Sus scrofa/fisiologia , Animais , Intestinos/imunologia , Distribuição Aleatória , Sus scrofa/crescimento & desenvolvimento , Sus scrofa/imunologia
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