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1.
Pediatr Rheumatol Online J ; 21(1): 11, 2023 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-36707855

RESUMO

OBJECTIVES: To characterize the clinical features and outcomes of childhood-onset primary Sjögren's syndrome (pSS). METHODS: Patients less than 18 years old who were diagnosed with pSS by paediatric rheumatologists were included, and all patients were applied the 2002 American-European Consensus Group (ACEG) criteria, the 2016 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria for pSS, or the 1999 proposed juvenile pSS criteria. The electronic medical records of patients with pSS from 2013 to 2020 were collected and analysed. RESULTS: Thirty-nine patients were included. Of them, 27 (69.2%), 38 (97.4%) and 35 (89.7%) patients fulfilled the AECG criteria, ACR/EULAR criteria and proposed juvenile pSS criteria, respectively. The female:male ratio was 3.9:1. The median ages at first signs or symptoms and at diagnosis were 9.2 (4.7, 14.5) years and 10.9 (6.3, 15.0) years, respectively. The main clinical manifestations were rash or purpura (20, 51.3%), followed by fever (12, 30.8%), glandular enlargement/recurrent parotitis (10, 25.6%), and dry mouth and/or dry eyes (9, 23.1%). Twenty-eight (56.4%) patients had systemic damage, the most common of which was haematological involvement (14, 35.9%), followed by hepatic (13, 33.3%) and renal involvement (8, 20.5%). Thirty-eight (97.4%) patients underwent labial minor salivary gland biopsy, and all exhibited focal lymphocytic sialadenitis. All patients had a global ESSDAI score ≥ 1 at diagnosis, and the median total score at diagnosis was 8 (2, 31). Thirty-six (92.3%) patients were followed up for a median time of 23.6 (7.9, 79.5) months, and three patients developed systemic lupus erythematosus (SLE) at follow-up times of 13.3, 38.8 and 63.8 months. CONCLUSIONS: The presentation of childhood-onset pSS is atypical, and extraglandular manifestations and systemic involvement are more common than in adult-onset pSS. Labial salivary gland biopsy is vital for patients with probable pSS. Some patients may develop SLE over time.

2.
Drug Deliv ; 30(1): 2168794, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36708154

RESUMO

The aim of this study is to demonstrate a method for improving the solubility and relative bioavailability of artemisinin using a self-emulsifying drug delivery system (SEDDS). The self-emulsifying drug load, solubility, and emulsifying time were used as the evaluation indices, based on a solubility test and a ternary phase diagram. Optimal Mixture Design in Design-Expert software was used to optimize the prescription of the artemisinin SEDDS. By determining the water distribution coefficient in vitro, combined with the drug concentration-time curve in vivo, a comparison was made of the relative oral bioavailability of the artemisinin SEDDS and the crude drug. The optimal prescription ratio of oleic acid polyethylene glycol glyceride, polyoxyethylene hydrogenated castor oil, and diethylene glycol monoethyl ether in the artemisinin SEDDS was 0.5:0.2:0.3 (wt/wt/wt), with a drug loading capacity of 41.556 mg/g, a solubility of 1.997 mg/mL, and a self-emulsification time of 214 s. The optimal prescription was transparent, slightly yellow, and oil-like. The average loading capacity of artemisinin was 41.912 mg/g, the emulsification time was 231 s, the average particle size was 128.0 nm, the average Zeta potential was -4.29 mV, and the solubility of artemisinin SEDDS in water was 1.997 mg mL-1. It is 33.85 times of the solubility of artemisinin in water, which achieves the purpose of increasing the solubility of artemisinin. The comparison of the oil/water distribution coefficient of the artemisinin SEDDS with that of the crude drug in vitro showed that SEDDS could improve the permeability of artemisinin and promote the absorption in vivo, and the relative bioavailability of the SEDDS agent was at least 1.47 times higher than that of the crude drug. The artemisinin SEDDS could significantly improve the solubility and relative bioavailability of artemisinin.

3.
Sci Rep ; 13(1): 1104, 2023 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-36670173

RESUMO

Coherent beam combining technology applied to multiple vortex beams is a promising method to generate high-power vortex beams. We utilize the coherent combination of multiple Laguerre-Gaussian beams at the waist plane and propose theoretically a practical generation system for a high-power beam carrying orbital angular momentum by considering oblique incidence. The results demonstrate that the orbital angular momentum distribution of the combined field is similar to that of a single Laguerre-Gaussian beam within the Rayleigh length. Moreover, the combined field has relativistic intensity local spots that exhibit stable spatial propagation. The proposed system may potentially be applied to intense vortical fields, large scale nuclear fusion device, such as suppressing stimulated Raman scattering and filamentation when a laser beam propagates in plasma.

4.
Artigo em Inglês | MEDLINE | ID: mdl-36701037

RESUMO

OPINION STATEMENT: Although chimeric antigen receptor T cell immunotherapy has been successfully applied in patients with hematological malignancies, several obstacles still need to be overcome, such as high relapse rates and side effects. Overcoming the limitations of CAR-T cell therapy and boosting the efficacy of CAR-T cell therapy are urgent issues that must be addressed. The exploration of small-molecule compounds in combination with CAR-T cell therapies has achieved promising success in pre-clinical and clinical studies in recent years. Protein kinase inhibitors, demethylating drugs, HDAC inhibitors, PI3K inhibitors, immunomodulatory drugs, Akt inhibitors, mTOR inhibitors, and Bcl-2 inhibitors exhibited potential synergy in combination with CAR-T cell therapy. In this review, we will discuss the recent application of these combination therapies for improved outcomes of CAR-T cell therapy.

5.
Mar Pollut Bull ; 187: 114513, 2023 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-36638717

RESUMO

Large-scale kelp aquaculture offers several opportunities to counteract eutrophication. Here, six sites from Ailian Bay to its offshore waters in Rongcheng, northern China, were selected to investigate the spatiotemporal variations of kelp (Saccharina japonica) and seawater concentrations of C, N, and P in 2017 and 2019 in order to assess nutrient removal by kelp farming. Variations in biological parameters and elemental nutrient concentrations of whole thalli were also quantified in 2015 and 2016. We found that kelp farming in Ailian Bay can remove 1309 tons of C, 104 tons of N, and 12 tons of P. The increase of total suspended matter and nutrient concentrations from the coast to offshore waters supports the hypothesis of nutrient removal by farmed kelp. This study provides evidence of the bioremediation potential of farmed kelp.

6.
PLoS One ; 18(1): e0277965, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36689409

RESUMO

We examine whether equity incentive can encourage exploratory innovation from the perspective of dynamic innovation decision-making process. Using the data of equity incentives in China's listed companies from 2006 to 2017, we construct exploratory intensity of innovation strategy and analyze the impact of equity incentive on corporation exploratory innovation strategy from both the cross-sectional and time-series perspectives. We find a positive relationship between the vesting period and explorative innovation strategy in the cross-sectional dimension. However, the time-series analyses show that the innovation strategy becomes less explorative and more exploitative after the third period during equity incentive. The effect of vesting period is stronger in smaller firms and during the non-financial crisis period. Further analysis reveals that followed by the changes in innovation strategy, the growth rates of innovation output and firm performance also decline.


Assuntos
Motivação , Organizações , Estudos Transversais , Tomada de Decisões
7.
Bioresour Technol ; : 128663, 2023 Jan 21.
Artigo em Inglês | MEDLINE | ID: mdl-36693504

RESUMO

Although magnetic modification has potential for preparing recyclable biochar, the traditional preparation methods of loading magnetic materials on biochar will probably lead to pore blockage and consequently remarkable adsorption recession. Herein, a preparation method was developed in which ball milled biochar was loaded with ultrafine magnetite and then milled for a second time, thus generating a magnetic, recyclable biochar with minimal pore blockage. The deposits of magnetite did not significantly wrap the biochar, although a decreased sorption performance was still detectable. Benefitting from the extra milling step, surface functional groups and specific surface areas of the adsorbents were largely restored, thus leading to a 93.8% recovery adsorption of 84.6±2.5 mg/L on methylene blue. Meanwhile, the recyclability of the material was not affected. The adsorption was driven by multiple interactions. These twice-milled magnetic biochar is quite outstanding for sustainable removal of aqueous contaminants with its recyclability and high sorption efficiency.

8.
Biomater Sci ; 2023 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-36648752

RESUMO

An elaborate design of multimodal antibacterial agents has been revealed to be a promising strategy to address bacterial resistance, originating from the abuse of antibiotics. In this work, we have developed a positively charged and porous material, FePPOPHydantoin, as a disinfectant via introducing 1,3-dibromo-5,5-dimethylhydantoin (Hydantoin) and porphyrin iron units into a polymer framework. The extended π conjugated networks of FePPOPHydantoin endowed the material with strong near-infrared (NIR) absorption, high density of surface catalytic active centers, superior stability, and reproducibility. FePPOPHydantoin exhibits high peroxidase mimetic and photo-Fenton activity, which can catalyze the biologically allowable maximum concentrations of hydrogen peroxide (100 µM) to produce a vast amount of hydroxyl radicals. Simultaneously, the effective electrostatic interaction between the positively charged FePPOPHydantoin and the negatively charged bacteria facilitates the binding of FePPOPHydantoin on the bacterial membrane, restricting bacteria within the destruction range of hydroxyl radicals and thus making the bacteria more vulnerable. Finally, further close contact between bacteria and Hydantoin units in FePPOPHydantoin gave the material an antibacterial efficiency of over 99.999%. Compared with chemical therapy, photo-Fenton therapy, or peroxidase catalytic therapy alone, FePPOPHydantoin had a noteworthy multi-amplified antibacterial efficiency. Furthermore, FePPOPHydantoin exhibited good biocompatibility and negligible cytotoxicity. The in vivo antibacterial therapy on the Staphylococcus aureus (S. aureus) infected mouse wound model clearly proved the effectiveness of FePPOPHydantoin for fighting bacterial infections. This work highlights opportunities for the design of nanozymes with enhanced bacteriostatic activity, providing a new avenue for the construction of novel antibiotics.

9.
Ann Biomed Eng ; 2023 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-36629950

RESUMO

For certain types of cancer patients, ovarian transplantation has a risk of malignant cancer cell infection. However, the autologous transplantation of an artificial ovary is safe and effective, guarantees the normal development of isolated follicles, regular oocyte maturation, and ovulation, partially restores endocrine function, and enables the patient to regain reproductive ability. Despite the complexity of the natural ovary, some progress has been made in the repair or replacement of reproductive tissues with the use of various biomaterials. This article reviews the physical structure, biomechanical properties, design elements, preparation routes, construction and practical use of natural polymer materials, usually hydrogel scaffolds, such as alginate, fibrin, gelatin, collagen, agarose, and acellular ovarian matrix in the preparation of artificial ovaries. We summarize how these materials can be made into artificial ovaries to achieve the conditions for fertility through follicle and oocyte development and identify several major issues to overcome for the future development of artificial ovaries, including how to establish blood recirculation, and how to establish hormone synthesis and release channels. This review is intended to provide a reference for the use of natural polymer biomaterials in reproductive clinics.

10.
Orphanet J Rare Dis ; 17(1): 422, 2022 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-36461028

RESUMO

BACKGROUND: Chronic active Epstein-Barr virus infection (CAEBV) is a rare but life-threatening progressive disease. Human leukocyte antigen (HLA)-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is the best choice as sometimes HLA-matched donor is not accessible. However, graft-versus-host-disease (GVHD) following transplantation remains a major cause of treatment failure and elevated mortality. Post-transplant cyclophosphamide (PTCy) has recently emerged for effective GVHD prophylaxis in a haploidentical setting in many hematologic malignancies. Here, we report the performance of PTCy for GVHD prophylaxis in a series of CEABV patients treated with haplo-HSCT. METHODS: Consecutive pediatric CAEBV patients who were treated with haplo-HSCT and give PTCy for GVHD prophylaxis were analyzed. 1-year GVHD and relapse-free survival (GRFS), overall survival (OS) and cumulative incidence of moderate-to-severe chronic GVHD (cGVHD) were estimated. RESULTS: A total of 8 patients ranging from 2 to 15 years old were included. Among them, 4 patients had early complications after haplo-HSCT. Counts of T-cell subsets increased within 6 months post transplantation, indicating an immune reconstitution. Only 1 patient developed grade II acute GVHD, and 2 patients had moderate cGVHD. One patient died from diffuse alveolar hemorrhage within the first year after transplantation. The 1-year GRFS rate, OS rate and cumulative incidence of moderate-to-severe cGVHD were 62.5%, 87.5% and 25.0%, respectively. CONCLUSION: Our findings suggest that, among CAEBV patients treated with haplo-HSCT, PTCy may be an alternative choice for the prevention of GVHD.


Assuntos
Infecções por Vírus Epstein-Barr , Doença Enxerto-Hospedeiro , Transplante de Células-Tronco Hematopoéticas , Criança , Humanos , Pré-Escolar , Adolescente , Infecções por Vírus Epstein-Barr/prevenção & controle , Doença Enxerto-Hospedeiro/tratamento farmacológico , Doença Enxerto-Hospedeiro/prevenção & controle , Herpesvirus Humano 4 , Ciclofosfamida/uso terapêutico , Infecção Persistente
11.
Am J Transl Res ; 14(11): 8252-8262, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36505333

RESUMO

OBJECTIVE: To summarize and evaluate the relevant evidence on nutrition management of post-stroke dysphagia (PSD) to provide evidence-based basis for clinical staff. METHODS: We searched evidence in BMJ Best Practice, Up To Date, Cochrane Library, PubMed and so on from their inception to May 31, 2021. The quality assessment was conducted by two researchers by using AGREE II for guidelines, JBI evidence-based health care center evaluate standards for systematic review and expert consensus. RESULTS: An initial searching of 445 literatures resulted in 26 literatures that met inclusion criteria. Finally, a total of 38 pieces of evidence were summarized from 5 aspects including nutrition risk screening and assessment, nutrition support principles, enteral nutrition, parenteral nutrition, and hydration management. CONCLUSIONS: This study summarized the evidence of the nutrition management for PSD patients. Since evidences are from different countries, it's better to assess the clinical environment and other related factors before their application.

12.
Front Plant Sci ; 13: 1075007, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36570919

RESUMO

Contamination of soils by microplastics can have profound ecological impacts on terrestrial ecosystems and has received increasing attention. However, few studies have considered the impacts of soil microplastics on plant communities and none has tested the impacts of spatial heterogeneity in the horizontal distribution of microplastics in the soil on plant communities. We grew experimental plant communities in soils with either a homogeneous or a heterogeneous distribution of each of six common microplastics, i.e., polystyrene foam (EPS), polyethylene fiber (PET), polyethylene bead (HDPE), polypropylene fiber (PP), polylactic bead (PLA) and polyamide bead (PA6). The heterogeneous treatment consisted of two soil patches without microplastics and two with a higher (0.2%) concentration of microplastics, and the homogeneous treatment consisted of four patches all with a lower (0.1%) concentration of microplastics. Thus, the total amounts of microplastics in the soils were exactly the same in the two treatments. Total and root biomass of the plant communities were significantly higher in the homogeneous than in the heterogeneous treatment when the microplastic was PET and PP, smaller when it was PLA, but not different when it was EPS, HDPE or PA6. In the heterogeneous treatment, total and root biomass were significantly smaller in the patches with than without microplastics when the microplastic was EPS, but greater when the microplastic was PET or PP. Additionally, in the heterogeneous treatment, root biomass was significantly smaller in the patches with than without microplastics when the microplastic was HDPE, and shoot biomass was also significantly smaller when the microplastic was EPS or PET. The heterogeneous distribution of EPS in the soil significantly decreased community evenness, but the heterogeneous distribution of PET increased it. We conclude that soil heterogeneity in the horizontal distribution of microplastics can influence productivity and species composition of plant communities, but such an effect varies depending on microplastic chemical composition (types) and morphology (shapes).

13.
Front Plant Sci ; 13: 1080674, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36531348

RESUMO

Many of the world's most invasive plants are clonal, and clonal functional traits are suggested to contribute to their invasiveness. Clonal integration is one of the most important clonal functional traits, but it is still unclear whether clonal integration can benefit invasive alien clonal plants more than native ones in heterogeneous environments with reciprocal patchiness of resources and whether invasive plants show a higher capacity of division of labor than native ones in such environments. We grew connected (allowing clonal integration) and disconnected (preventing clonal integration) ramet pairs of an invasive plant Wedelia trilobata and its occurring native congener W. chinensis in the environment consisting of reciprocal patches of light and soil nutrients (i.e., a high-light but low-nutrient patch and a low-light but high-nutrient patch). Clonal integration greatly promoted the growth of the invasive species, but had no significant effect on the native one. Both invasive and native species showed division of labor in terms of morphology, biomass allocation, and/or photosynthetic physiology, but the capacity of labor division did not differ between the invasive and the native species. We conclude that in heterogeneous environments consisting of reciprocal patches of resources, which are common in nature, clonal integration can confer invasive plants a competitive advantage over natives, but this difference is not related to their capacity of labor division. This study highlights the importance of clonal integration for plants in heterogeneous environments and suggests that clonal integration can contribute to the invasion success of alien clonal plants.

14.
Polymers (Basel) ; 14(21)2022 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-36365563

RESUMO

In order to explore the methods of recycling waste paper, reduce environment pollution, and develop a circular economy, the application of waste corrugated paper to the strengthening of polylactic acid (PLA) was studied. Plant fiber from waste corrugated paper (WCPF) was used to prepare WCPF/PLA composite via co-extrusion. The WCPF was extracted from the waste corrugated paper by beating in a Valli beating machine and grinding in a disc grinder. KH-550 coupling agent was used to modify the surface of WCPF to improve the interface adhesive strength between the WCPF and PLA matrix. The effects of the contents of WCPF and KH-550 coupling agent on the mechanical properties, microstructure, crystallization properties, and thermostability of the WCPF/PLA composite were studied. The results show that the WCPF can be well separated from each other. The WCPF can be uniformly dispersed in the PLA matrix through a co-extrusion process. WCPF can increase the mechanical strength and deformation resistance ability of WCPF/PLA composite, and KH-550 coupling agent can further improve that of the WCPF/PLA composite. This study is of obvious significance to the recycling of waste paper and the development of a circular economy.

15.
Nat Prod Res ; : 1-6, 2022 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-36323318

RESUMO

Colletotrin A (1), a new 1,4-benzoxazine derivative, and eight known compounds, including two alkaloids (2-3), one acylamide (4), one benzaldehyde (5), and four sterols (6-9) were obtained from endophytic fungus Colletotrichum gloeosporioides B-142, which was isolated from Dracaena cochinchinensis. Among them, 1,2,3,4-tetrahydroquinoline-4,8-diol (2) was reported for the first time as natural product. The structure of compound 1 was elucidated with help of spectroscopic data including IR, UV, electronic circular dichroism (ECD) calculation, HRESIMS, 1D and 2D NMR (COSY, HSQC and HMBC). The antimicrobial activities were evaluated by disc diffusion method.

17.
Org Biomol Chem ; 20(45): 8849-8854, 2022 11 23.
Artigo em Inglês | MEDLINE | ID: mdl-36326261

RESUMO

An enantioselective addition of 5-amino-isoxazoles with ß,γ-alkynyl-α-ketimino esters catalyzed by a chiral phosphoric acid has been developed. This procedure allowed the formation of quaternary α-isoxazole-α-alkynyl amino acid derivatives with high yields (up to 99%) and good to excellent enantioselectivities (up to 97%), and the corresponding products enabled many further elaborations. The control experiment revealed that the hydrogen-bonding interaction of 5-amino-isoxazole with the chiral phosphoric acid played a vital role in the enantioselectivity, and the transition state of the reaction was proposed.


Assuntos
Aminoácidos , Isoxazóis , Estereoisomerismo , Estrutura Molecular , Catálise , Aminoácidos/química
18.
Front Psychiatry ; 13: 1017888, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36276314

RESUMO

Objective: Bipolar depression (BD) and major depressive disorder (MDD) are both common affective disorders. The common depression episodes make it difficult to distinguish between them, even for experienced clinicians. Failure to properly diagnose them in a timely manner leads to inappropriate treatment strategies. Therefore, it is important to distinguish between BD and MDD. The aim of this study was to develop and validate a nomogram model that distinguishes BD from MDD based on the characteristics of lymphocyte subsets. Materials and methods: A prospective cross-sectional study was performed. Blood samples were obtained from participants who met the inclusion criteria. The least absolute shrinkage and selection operator (LASSO) regression model was used for factor selection. A differential diagnosis nomogram for BD and MDD was developed using multivariable logistic regression and the area under the curve (AUC) with 95% confidence interval (CI) was calculated, as well as the internal validation using a bootstrap algorithm with 1,000 repetitions. Calibration curve and decision curve analysis (DCA) were used to evaluate the calibration and clinical utility of the nomogram, respectively. Results: A total of 166 participants who were diagnosed with BD (83 cases) or MDD (83 cases), as well as 101 healthy controls (HCs) between June 2018 and January 2022 were enrolled in this study. CD19+ B cells, CD3+ T cells, CD3-CD16/56+ NK cells, and total lymphocyte counts were strong predictors of the diagnosis of BD and MDD and were included in the differential diagnosis nomogram. The AUC of the nomogram and internal validation were 0.922 (95%; CI, 0.879-0.965), and 0.911 (95% CI, 0.838-0.844), respectively. The calibration curve used to discriminate BD from MDD showed optimal agreement between the nomogram and the actual diagnosis. The results of DCA showed that the net clinical benefit was significant. Conclusion: This is an easy-to-use, repeatable, and economical nomogram for differential diagnosis that can help clinicians in the individual diagnosis of BD and MDD patients, reduce the risk of misdiagnosis, facilitate the formulation of appropriate treatment strategies and intervention plans.

19.
Medicine (Baltimore) ; 101(42): e31151, 2022 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-36281175

RESUMO

The downward referral platform in the regional medical alliance has provided more possibilities to follow-up rehabilitation and transitional care for increasing stroke survivors, which also has the most contributions in the rational use of resources and health promotion of stroke survivors. However the downward referral rate is low compared to upward referral. At present, no scholars have explored the downward referral experiences of medical demanders from the perspective of qualitative study, and these experiences may also most truly reflect the influencing factors of their unwillingness to downward referral. Therefore, this study explored the subjective experiences of stroke caregivers who had experienced the downward referral, because stroke attacks often lead to lack of autonomy of patients themselves, making it difficult to complete interviews with them. A descriptive phenomenological study was adopted. A purposive sampling strategy was used to recruit 13 stroke caregivers. Interviews were guided by a semi-structured interview-guide encouraging interviewees to reflect on their experiences with downward referral. Coliazzi's data analysis process was applied. The analysis of the data revealed 4 themes: coping challenges; disrupted information; gaps in medical and nursing transition, and potential enabling factors. The results of this study showed that the lack of knowledge of medical alliance, non-sharing of medical information and non-homogeneousness of medical quality were identified to be impeding positive attitude towards downward referral and be factors of bad experiences. Of course, the interviewees had positive experiences such as smooth referral and comfortable environment. These may be potential enabling factors to their attitude towards downward referral. The challenges and needs of medical demanders after downward referral are worthy of attention, and these should be solved by corresponding measures to improve the downward referral rate and referral experiences.


Assuntos
Reabilitação do Acidente Vascular Cerebral , Acidente Vascular Cerebral , Humanos , Cuidadores , Acidente Vascular Cerebral/terapia , Encaminhamento e Consulta , Pesquisa Qualitativa
20.
Open Med (Wars) ; 17(1): 1550-1558, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36245703

RESUMO

Autoimmune liver diseases (AILDs) are life-threatening chronic liver diseases, mainly including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and AIH-PBC overlap syndrome (OS), which are difficult to distinguish clinically at early stages. This study aimed to establish model to achieve the purpose of the diagnosis of AIH/PBC OS in a noninvasive way. A total of 201 AILDs patients were included in this retrospective study who underwent liver biopsy during January 2011 to December 2020. Serological factors significantly associated with OS were determined by the univariate analysis. Two multivariate models based on these factors were constructed to predict the diagnosis of AIH/PBC OS using logistic regression and random forest analysis. The results showed that immunoglobulins G and M had significant importance in both models. In logistic regression model, anti-Sp100, anti-Ro-52, anti-SSA, or antinuclear antibody positivity were risk factors for OS. In random forest model, activated partial thromboplastin time and ɑ-fetoprotein level were important. To distinguish PBC and OS, the sensitivity and specificity of logistic regression model were 0.889 and 0.727, respectively, and the sensitivity and specificity of random forest model were 0.944 and 0.818, respectively. In conclusion, we established two predictive models for the diagnosis of AIH/PBC OS in a noninvasive method and they showed better performance than Paris criteria for the definition of AIH/PBC OS.

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