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1.
Sci Prog ; 104(4): 368504211059038, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34825592

RESUMO

To solve the problem of difficult quantitative identification of surface defect depth during laser ultrasonic inspection, a support vector machine-based method for quantitative identification of surface rectangular defect depth is proposed. Based on the thermal-elastic mechanism, the finite element model for laser ultrasound inspection of aluminum materials containing surface defects was developed by using the finite element software COMSOL. The interaction process between laser ultrasound and rectangular defects was simulated, and the reflected wave signals corresponding to defects of different depths under pulsed laser irradiation were obtained. Laser ultrasonic detection experiments were conducted for surface defects of different depths, and multiple sets of ultrasonic signal waveform were collected, and several feature vectors such as time-domain peak, center frequency peak, waveform factor and peak factor were extracted by using MATLAB, the quantitative defect depth identification model based on support vector machine was established. The experimental results show that the laser ultrasonic surface defect identification model based on support vector machine can achieve high accuracy prediction of defect depth, the regression coefficient of determination is kept above 0.95, and the average relative error between the true value and the predicted value is kept below 10%, and the prediction accuracy is better than that of the reflection echo method and BP neural network model.

2.
Diabetes Metab Syndr Obes ; 14: 4469-4482, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34795494

RESUMO

Purpose: To analyze the impact of hyperglycemia on the clinical outcome of COVID-19 in patients with newly diagnosed diabetes (NDD). Patients and Methods: We performed a retrospective study of 3114 cases of COVID-19 without pre-existing diabetes, 351 of which had NDD, in Hubei Province, China. The Cox regression model was used to calculate the risk of adverse clinical outcomes comparing the NDD vs non-NDD group before and after propensity score-matched (PSM) analysis. Patients with NDD were further divided into a sustained hyperglycemia group, a fluctuating group, and a remitted group based on their blood glucose levels during hospitalization as well as into hypoglycemic agent users and nonusers. Results: Compared to the non-NDD individuals, individuals with NDD had a significantly increased risk of all-cause mortality (adjusted HR after PSM, 2.65; 95% CI, 1.49-4.72; P = 0.001) and secondary outcomes involving organ damage during the 28-day follow-up period. Subgroup analyses indicated that among individuals with NDD, the individuals with remitted hyperglycemia had the lowest 28-day mortality, whereas those with sustained hyperglycemia had the highest (IRR 24.27; 95% CI, 3.21-183.36; P < 0.001). Moreover, individuals treated with hypoglycemic agents had significantly lower all-cause mortality than those not treated with hypoglycemic agents (IRR 0.08; 95% CI, 0.01-0.56; P < 0.001). Conclusion: Our study reinforces the clinical message that NDD is strongly associated with poor outcomes in COVID-19 patients. Furthermore, resolved hyperglycemia in the later phase of the disease and the use of hypoglycemic agents were associated with improved prognosis in patients with NDD.

3.
Cell Metab ; 33(10): 1943-1956.e2, 2021 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-34478633

RESUMO

Metabolic dysfunction is becoming a predominant risk for the development of many comorbidities. Ischemic heart disease (IHD) still imposes the highest disease burden among all cardiovascular diseases worldwide. However, the contributions of metabolic risk factors to IHD over time have not been fully characterized. Here, we analyzed the global disease burden of IHD and 15 associated general risk factors from 1990 to 2019 by applying the methodology framework of the Global Burden of Disease Study. We found that the global death cases due to IHD increased steadily during that time frame, while the mortality rate gradually declined. Notably, metabolic risk factors have become the leading driver of IHD, which also largely contributed to the majority of IHD-related deaths shifting from developed countries to developing countries. These findings suggest an urgent need to implement effective measures to control metabolic risk factors to prevent further increases in IHD-related deaths.

4.
World J Clin Cases ; 9(24): 7231-7236, 2021 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-34540983

RESUMO

BACKGROUND: Splenic hamartoma (SH) is a rare, benign vascular proliferation that is often found incidentally. It may be misdiagnosed as a splenic aneurysm or splenic malignancy. CASE SUMMARY: A 21-year-old male patient was admitted to our hospital with a complaint of an incidentally discovered asymptomatic splenic space-occupying lesion for 2 wk. Abdominal computed tomography (CT) scan showed a circular low-density shadow in the hilum of the spleen. Contrast-enhanced CT revealed an aneurysm located in the hilum of the spleen before operation. Laparoscopic splenectomy was performed and postoperative pathology revealed the presence of SH. CONCLUSION: Imaging studies are insufficient for the differential diagnosis of SH from other diseases, and laparoscopic splenectomy is a less invasive procedure and useful for the diagnostic purpose as well.

5.
Artigo em Inglês | MEDLINE | ID: mdl-34445887

RESUMO

Erysiphe necator is an economically important biotrophic fungal pathogen responsible for powdery mildew disease on grapevine. Currently, genome sequences are available for only a few Erysiphe necator isolates from USA. Based on the combination of Nanopore and Illumina sequencing technologies, we present here the complete genome assembly for an isolate of E. necator NAFU1 identified in China. We acquired a total of 15.93 Gb raw reads. These reads were processed into a 61.12 Mb genome assembly containing 73 contigs with the N50 of 2.06 Mb and a maximum length of 6.05 Mb. Combining the results of three gene-prediction modules, i.e. an evidence-based gene modeler (EVidenceModeler or EVM), an ab initio gene modeler, and a homology-based gene modeler, we predicted 7235 protein-coding genes in the assembled genome of E. necator NAFU1. This information will facilitate studies of genome evolution and pathogenicity mechanisms of E. necator and other powdery mildew species through comparative genome sequence analysis and other molecular genetic tools.

6.
J Neuroinflammation ; 18(1): 130, 2021 Jun 11.
Artigo em Inglês | MEDLINE | ID: mdl-34116703

RESUMO

BACKGROUND: Astrocytes are the predominant glial cell type in the central nervous system (CNS) that can secrete various cytokines and chemokines mediating neuropathology in response to danger signals. D-dopachrome tautomerase (D-DT), a newly described cytokine and a close homolog of macrophage migration inhibitory factor (MIF) protein, has been revealed to share an overlapping function with MIF in some ways. However, its cellular distribution pattern and mediated astrocyte neuropathological function in the CNS remain unclear. METHODS: A contusion model of the rat spinal cord was established. The protein levels of D-DT and PGE2 synthesis-related proteinase were assayed by Western blot and immunohistochemistry. Primary astrocytes were stimulated by different concentrations of D-DT in the presence or absence of various inhibitors to examine relevant signal pathways. The post-injury locomotor functions were assessed using the Basso, Beattie, and Bresnahan (BBB) locomotor scale. RESULTS: D-DT was inducibly expressed within astrocytes and neurons, rather than in microglia following spinal cord contusion. D-DT was able to activate the COX2/PGE2 signal pathway of astrocytes through CD74 receptor, and the intracellular activation of mitogen-activated protein kinases (MAPKs) was involved in the regulation of D-DT action. The selective inhibitor of D-DT was efficient in attenuating D-DT-induced astrocyte production of PGE2 following spinal cord injury, which contributed to the improvement of locomotor functions. CONCLUSION: Collectively, these data reveal a novel inflammatory activator of astrocytes following spinal cord injury, which might be beneficial for the development of anti-inflammation drug in neuropathological CNS.

7.
Sex Med ; 9(3): 100349, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34087534

RESUMO

INTRODUCTION: Phenotype switch refers to the process in which smooth muscle cells change from contractile type to synthetic type and acquire the ability of proliferation. Phenotypic transformation involves many changes of cell function, such as collagen deposition and fibrosis, which affect the normal erectile function of penis. AIM: To investigate the role of miR-195-5p in regulating the Phenotype switch of the corpus cavernosum smooth muscle (CCSM) cells. METHODS: A small mother against decapentaplegic 7(Smad7) virus vector and a miR-195-5p mimics or an si-Smad7 viral vector and a miR-195-5p inhibitor were transfected into CCSM cells. The cells were obtained by primary culture of rat corpus cavernosum smooth muscle tissue. Real-time polymerase chain reaction (PCR) experiments, Western blotting, hematoxylin-eosin (HE) staining, transwell experiments, MTT assays, and flow cytometry were used to detect miR-195-5p, Smad7, phenotype switch markers of CCSM cells and related protein expression, as well as changes in cell morphology, migration, proliferation and apoptosis. MAIN OUTCOME MEASURE: To study the regulation of miR-195-5p in CCSM cells by overexpression and silencing strategies. RESULTS: Overexpressed miR-195-5p promoted the transformation of CCSM cells from a contractile type to a synthetic type. Meanwhile, the migration ability and proliferation ability of CCSM cells increased, and the apoptosis rate decreased. The expression-silencing of miR-195-5p gave rise to the opposite effect. The results of the rescue experiment demonstrated that overexpressed Smad7 rescued the inhibitory of the switch of the CCSM cell phenotype from the contractile type to the synthesis type caused by overexpression of miR-195-5p alone. Moreover, the enhancement effect of the migration ability and proliferation ability of CCSM cells was also eliminated, and the apoptosis rate was increased. Silencing miR-195-5p and Smad7 at the same time resulted in the opposite effect. CONCLUSION: miR-195-5p may regulate the phenotype switch of CCSM cells by targeting Smad7. Zhang J, Zhang X, Zhang J, et al. miR-195-5p Regulates the Phenotype Switch of CCSM Cells by Targeting Smad7. Sex Med 2021;9:100349.

8.
Insects ; 12(5)2021 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-33946774

RESUMO

The stick tea thrip Dendrothrips minowai (Priesner) (Thysanoptera: Thripidae) is a destructive pest in tea plantations in south and southwest China. To control this pest, a non-crop banker plant system was developed using a polyphagous predator Orius strigicollis (Poppius) (Heteroptera: Anthocoridae) with the black bean aphid Aphis fabae (Scopoli) (Hemiptera: Aphididae) as an alternative prey and the faba bean Vicia faba as the banker plant to support the predator in targeting the pest. The fitness of A. fabae on tea plants and faba bean was evaluated to determine its host specificity. Moreover, the control efficacy of the banker plant system on D. minowai on tea plants was tested in the laboratory and compared with that of direct release of O. strigicollis. The experiments showed that faba bean was an excellent non-crop host for A. fabae because, while the aphid population increased quickly on faba bean, it could only survive for up to 9 days on tea plants. Compared with direct release of O. strigicollis, lower densities of pest were observed when introducing the banker plant system. Our results indicate that this banker plant system has the potential to be implemented in the field to improve the control of the pest thrips.

9.
Yonsei Med J ; 62(5): 453-460, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33908217

RESUMO

PURPOSE: Multiple pathways are involved in inducing liver fibrosis, which can damage the integrity of liver. Among them, miR-125b has been found to exert an activating action on hepatic stellate cells. Endoplasmic reticulum stress and autophagy lead to liver disorders. Here, we evaluated the therapeutic influence of miR-125b on the endoplasmic reticulum function in injured livers submitted to bile duct ligation. MATERIALS AND METHODS: For inducing injury, bile duct ligation was done on miR-125b transgenic rats (miR-125b-Tg) in wild type rats. The rat T-6 cells received transfection of miR-125b mimic and Tunicamycin. Protein expressions were observed by western blot analysis. RESULTS: Compared to wild type rats, liver-injured rats showed significant impairment of liver function as assessed by the total bilirubin levels. The miR-125b-Tg rats showed decrease in activity of aspartate transaminase and alanine transaminase. Liver tissues of miR-125b-Tg rats showed weaker fibrotic matrix formation. Upregulation of miR-125b decreased the bile duct ligation-mediated hepatic disturbances for the expressions of endoplasmic reticulum kinase, inositol-requiring kinase 1alpha, sXBP1, CHOP, LC3, p62, ULK, and caspase-3/-8/-9. T-6 cells transfected with miR-125b mimic and treated with Tunicamycin caused decrease in levels of cleaved caspase-3, sXBP1, CHOP, and LC3. The miR-125b signaling showed protective effect on the liver tissues subjected to injury and fibrosis histopathology. CONCLUSION: This study demonstrates a novel insight into the miR125b-mediated stabilization of endoplasmic reticulum integrity, which slows the progression of injury-induced hepatic deterioration.


Assuntos
Icterícia Obstrutiva , MicroRNAs , Animais , Fibrose , Fígado/patologia , Cirrose Hepática/genética , Cirrose Hepática/patologia , MicroRNAs/genética , Ratos , Transdução de Sinais
10.
Curr Med Res Opin ; 37(6): 917-927, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33729889

RESUMO

BACKGROUND: To develop a sensitive and clinically applicable risk assessment tool identifying coronavirus disease 2019 (COVID-19) patients with a high risk of mortality at hospital admission. This model would assist frontline clinicians in optimizing medical treatment with limited resources. METHODS: 6415 patients from seven hospitals in Wuhan city were assigned to the training and testing cohorts. A total of 6351 patients from another three hospitals in Wuhan, 2169 patients from outside of Wuhan, and 553 patients from Milan, Italy were assigned to three independent validation cohorts. A total of 64 candidate clinical variables at hospital admission were analyzed by random forest and least absolute shrinkage and selection operator (LASSO) analyses. RESULTS: Eight factors, namely, Oxygen saturation, blood Urea nitrogen, Respiratory rate, admission before the date the national Maximum number of daily new cases was reached, Age, Procalcitonin, C-reactive protein (CRP), and absolute Neutrophil counts, were identified as having significant associations with mortality in COVID-19 patients. A composite score based on these eight risk factors, termed the OURMAPCN-score, predicted the risk of mortality among the COVID-19 patients, with a C-statistic of 0.92 (95% confidence interval [CI] 0.90-0.93). The hazard ratio for all-cause mortality between patients with OURMAPCN-score >11 compared with those with scores ≤ 11 was 18.18 (95% CI 13.93-23.71; p < .0001). The predictive performance, specificity, and sensitivity of the score were validated in three independent cohorts. CONCLUSIONS: The OURMAPCN score is a risk assessment tool to determine the mortality rate in COVID-19 patients based on a limited number of baseline parameters. This tool can assist physicians in optimizing the clinical management of COVID-19 patients with limited hospital resources.


Assuntos
COVID-19 , Medição de Risco/métodos , COVID-19/epidemiologia , COVID-19/mortalidade , China , Hospitalização/estatística & dados numéricos , Humanos , Itália , Fatores de Risco
11.
Medicine (Baltimore) ; 100(6): e24635, 2021 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-33578581

RESUMO

RATIONALE: Duodenal neuroendocrine tumor (d-NET) is a rare tumor originating in the neuroendocrine system. The clinical manifestations of d-NET are similar to those of other digestive tract tumors, resulting in a lack of specificity and complex clinical symptoms. PATIENT CONCERNS: A 55-year-old female patient was admitted to our hospital with a chief complaint of an abdominal mass that had been present for more than 4 months. DIAGNOSES: The upper abdomen enhanced computed tomography scan showed an uneven density mass across the upper abdomen, and the tumor size was approximately 6.2 × 5.8 cm with obvious visible enhancement present in 1 area and a cystic nonenhanced area. The postoperative pathology showed the tumor cells to be positive for chromogranin, synaptophysin, cytokeratin, CD56 (partial weak), negative for vimentin, CD117, DOG-1, CD34, S-100, SMA, desmin, and Ki-67 approximately 2%, which confirmed the diagnosis of d-NETs. INTERVENTIONS: We preferred laparoscopic surgical exploration, but the tumor started at the ascending part of the duodenum and involved the mesenteric artery. As the branches of the superior mesenteric artery were intertwined with the tumor, it was difficult to operate with the endoscope, so we converted to open laparotomy. The postoperative pathology revealed the presence of d-NET. OUTCOMES: The patient recovered uneventfully and was discharged after the operation. One-month and 3-month follow-up after surgery, showed no evidence of recurrence. LESSONS: Radiological imaging studies are insufficient for the differential diagnosis of abdominal mass from other diseases, whereas surgery is the only radical treatment method, and the preferred surgical method is still active radical resection of the tumor.


Assuntos
Neoplasias Duodenais/diagnóstico , Tumores Neuroendócrinos/diagnóstico , Diagnóstico Diferencial , Neoplasias Duodenais/diagnóstico por imagem , Neoplasias Duodenais/cirurgia , Feminino , Humanos , Laparotomia , Pessoa de Meia-Idade , Tumores Neuroendócrinos/diagnóstico por imagem , Tumores Neuroendócrinos/cirurgia , Tomografia Computadorizada por Raios X
12.
IEEE Trans Pattern Anal Mach Intell ; 43(4): 1239-1253, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31689183

RESUMO

Just like many other topics in computer vision, image classification has achieved significant progress recently by using deep learning neural networks, especially the Convolutional Neural Networks (CNNs). Most of the existing works focused on classifying very clear natural images, evidenced by the widely used image databases, such as Caltech-256, PASCAL VOCs, and ImageNet. However, in many real applications, the acquired images may contain certain degradations that lead to various kinds of blurring, noise, and distortions. One important and interesting problem is the effect of such degradations to the performance of CNN-based image classification and whether degradation removal helps CNN-based image classification. More specifically, we wonder whether image classification performance drops with each kind of degradation, whether this drop can be avoided by including degraded images into training, and whether existing computer vision algorithms that attempt to remove such degradations can help improve the image classification performance. In this article, we empirically study those problems for nine kinds of degraded images-hazy images, motion-blurred images, fish-eye images, underwater images, low resolution images, salt-and-peppered images, images with white Gaussian noise, Gaussian-blurred images, and out-of-focus images. We expect this article can draw more interests from the community to study the classification of degraded images.

13.
Zhonghua Nan Ke Xue ; 26(8): 713-716, 2020 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-33377732

RESUMO

Objective: To investigate the effects of bilateral microsurgical subinguinal varicocelectomy (BMSV) in patients with asthenozoospermia or oligozoospermia. METHODS: Totally 147 patients with male infertility received BMSV from January 2018 to May 2019, of whom 109 had complete data recorded. We retrospectively analyzed the clinical data, including the total sperm count per ejeculate, sperm concentration and sperm motility before and after surgery, and the rate of natural conception achieved during the follow-up. RESULTS: BMSV achieved a total effectiveness rate of 79.00% in improving the percentage of progressively motile sperm (a rise of ≥20%) and a marked effectiveness rate of 70.00% (a rise of ≥50%) in the 100 cases of asthenozoospermia as compared with the baseline, with a mean recovery time of (110.13 ± 37.43) days. Besides, a total effectiveness rate of 74.29% (an increase of ≥20%) and a marked effectiveness rate of 71.43% (an increase of ≥50%) were attained in the improvement of sperm concentration in the 35 cases of oligozoospermia, with a mean recovery time of (117.00 ± 48.79 ) days. A natural conception rate of 30.30% was observed during the follow-up. No severe adverse events occurred postoperatively. CONCLUSIONS: BMSV is significantly effective for the treatment of asthenozoospermia and oligozoospermia.


Assuntos
Astenozoospermia , Oligospermia , Varicocele , Astenozoospermia/cirurgia , Humanos , Masculino , Microcirurgia , Oligospermia/cirurgia , Estudos Retrospectivos , Contagem de Espermatozoides , Motilidade Espermática , Resultado do Tratamento , Varicocele/cirurgia
14.
Gastroenterol Res Pract ; 2020: 8914367, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32802047

RESUMO

Background: Intraoperative fluid (IOF) administration plays an important role during major abdominal surgery although increased fluid intake can adversely influence postoperative outcomes. However, the effect of the IOF rate on the outcomes of pancreatoduodenectomy (PD) is unclear. Methods: 151 patients, who underwent PD at Binzhou Medical University Hospital between January 2010 and May 2017, were categorized into three groups according to IOF rates (ml/kg/hr): restricted (<10, n = 47), standard (10-15, n = 76), and liberal (>15, n = 28). Results: The overall postoperative morbidity was 56.95%. The incidence of postoperative pancreatic fistula (POPF) was 11.26%. The in-hospital mortality rate was 7.28% with the most common cause being grade C POPF and secondary intra-abdominal infections. The patients in the liberal group had significantly higher incidences of POPF (25%) and respiratory complications (21.43%). The other outcome parameters such as recovery of bowel function, hospital stay, and postoperative daily drainage were similar among the groups. Multivariable analysis confirmed the IOF rate to be most strongly associated with POPF (odds ratio: 5.195, confidence interval: 1.142-23.823, P = 0.023) and respiratory complications (odds ratio: 7.302, confidence interval: 0.676-58.231, P = 0.025). Conclusions: The IOF rate significantly affects the incidence of POPF and respiratory complications after PD. Careful patient-oriented fluid therapy may help to prevent these complications.

15.
Environ Geochem Health ; 42(11): 3899-3909, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32632911

RESUMO

Kongyu Gold Mining Area is located in the northern margin of the Sichuan-Yunnan tectonic belt. This area has gone through two large tectonic cycles of Mesoproterozoic, Neoproterozoic and Phanerozoic. The strata are accompanied by a large number of tensile cracks, shear cracks and microfissures. The voidage, permeability and transitional effect of the rock are increased, and the transformation between surface water and groundwater is enhanced. On the other hand, tectonic movement controls the distributions and allocations of elements in the earth's crust, resulting in directional geochemical changes in crustal materials and rules. Driven by the tectonic force, the elements are reallocated. The ion content and ion compressibility of those elements increase and decrease inversely. The manifestations of rocks and minerals under directional pressure can be characterized by the flow and puncture of plastic minerals and the fragmentation of hard and brittle minerals. In the process of leaching, the pollutant elements precipitate from the deposits of different granular ores, and most are absorbed by the soil column; thus, the mass fraction of polluting elements in the soil column obviously increases. The variability is the largest when the leachate passes through the fine ore. The rate of change of the element mass fraction from high to low is Ni, Zn, Cu, Cd, Pb, As and Cr. A small part migrated from the soil column to the collection fluid, and the leaching effect is related to the rate of change of soil mass fraction, the ion radius of elements and the compressibility.


Assuntos
Metais/análise , Poluentes do Solo/análise , Solo/química , China , Monitoramento Ambiental/métodos , Fenômenos Geológicos , Ouro , Água Subterrânea/química , Minerais/análise , Mineração , Rios , Poluentes Químicos da Água/análise
16.
Hypertension ; 76(4): 1104-1112, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32673499

RESUMO

The prognostic power of circulating cardiac biomarkers, their utility, and pattern of release in coronavirus disease 2019 (COVID-19) patients have not been clearly defined. In this multicentered retrospective study, we enrolled 3219 patients with diagnosed COVID-19 admitted to 9 hospitals from December 31, 2019 to March 4, 2020, to estimate the associations and prognostic power of circulating cardiac injury markers with the poor outcomes of COVID-19. In the mixed-effects Cox model, after adjusting for age, sex, and comorbidities, the adjusted hazard ratio of 28-day mortality for hs-cTnI (high-sensitivity cardiac troponin I) was 7.12 ([95% CI, 4.60-11.03] P<0.001), (NT-pro)BNP (N-terminal pro-B-type natriuretic peptide or brain natriuretic peptide) was 5.11 ([95% CI, 3.50-7.47] P<0.001), CK (creatine phosphokinase)-MB was 4.86 ([95% CI, 3.33-7.09] P<0.001), MYO (myoglobin) was 4.50 ([95% CI, 3.18-6.36] P<0.001), and CK was 3.56 ([95% CI, 2.53-5.02] P<0.001). The cutoffs of those cardiac biomarkers for effective prognosis of 28-day mortality of COVID-19 were found to be much lower than for regular heart disease at about 19%-50% of the currently recommended thresholds. Patients with elevated cardiac injury markers above the newly established cutoffs were associated with significantly increased risk of COVID-19 death. In conclusion, cardiac biomarker elevations are significantly associated with 28-day death in patients with COVID-19. The prognostic cutoff values of these biomarkers might be much lower than the current reference standards. These findings can assist in better management of COVID-19 patients to improve outcomes. Importantly, the newly established cutoff levels of COVID-19-associated cardiac biomarkers may serve as useful criteria for the future prospective studies and clinical trials.


Assuntos
Infecções por Coronavirus , Creatina Quinase Forma MB/sangue , Cardiopatias , Peptídeo Natriurético Encefálico/sangue , Pandemias , Fragmentos de Peptídeos/sangue , Pneumonia Viral , Troponina I/sangue , Betacoronavirus/isolamento & purificação , Biomarcadores/sangue , COVID-19 , China/epidemiologia , Infecções por Coronavirus/sangue , Infecções por Coronavirus/mortalidade , Infecções por Coronavirus/terapia , Feminino , Cardiopatias/sangue , Cardiopatias/mortalidade , Cardiopatias/virologia , Hospitalização/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Mortalidade , Avaliação de Resultados em Cuidados de Saúde , Pneumonia Viral/sangue , Pneumonia Viral/mortalidade , Pneumonia Viral/terapia , Valor Preditivo dos Testes , Prognóstico , Estudos Retrospectivos , SARS-CoV-2
17.
Artigo em Inglês | MEDLINE | ID: mdl-32356750

RESUMO

By involving only subtle motions of body parts, video-based microaction recognition is a very important but challenging problem. Most existing action recognition methods are developed for general actions, and the current state-of-the-art methods usually largely rely on high-layer features learned from convolutional neural networks (CNNs). High-layer CNN features usually contain more semantic information but less detailed information. However, detailed information can be important for microactions due to the motion subtleness of such actions. In this paper, we propose to more effectively learn midlayer CNN features for enhancing microaction recognition. More specifically, we develop a new dual-branch network for microaction recognition: one branch uses the high-layer CNN features for classification, and the second branch further explores the midlayer CNN features for classification. In the second branch, we introduce a novel subtle motion detector consisting of three modules: 1) a discriminative spatial-temporal feature learning module, which further learns the subtle motion features corresponding to the discriminative spatial-temporal regions, 2) a parallel multiplier attention module, which further refines the features learned in channels and spatial-temporal domains, and 3) an activation fusion module, which fuses the max and average activations from midlayer CNN features for classification. In the experiments, we build a new microaction video dataset, where the micromotions of interest are mixed with other larger general motions such as walking. Comprehensive experimental results verify that the proposed method yields new state-of-the-art performance in two microaction video datasets, while its performance on two generalaction video datasets is also very promising.

18.
Pathol Res Pract ; 216(6): 152982, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32360250

RESUMO

BACKGROUND: Dysregulation of miRNAs is closely involved with hepatocellular carcinoma (HCC) progression, oncogenesis and signalling pathways. The aim of this study was to investigate differences in expression of miRNAs in HCC tissue in comparison to healthy liver tissue, as well as to explore the key miRNA-targeted genes. METHODS: Gene Chip microarray analysis was used to analyse differentially expressed miRNAs (DEMs) in tissues, and qRT-PCR was performed to validate the top 9 downregulated miRNAs. Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes pathway (KEGG) enrichment analyses were performed for target genes using the DAVID database. A protein-protein interaction (PPI) network of the target genes was created by STRING and visualised using Cytoscape. Three online miRNA databases were utilised to aid in the prediction of genes targeted by the top 10 significantly altered DEMs. RESULTS: In total, 153 upregulated and 206 downregulated miRNAs were identified in HCC tissue. The genes targeted by the top 10 increased and decreased miRNAs were 6 and 1060, respectively. Moreover, FOXO1 was projected to be regulated by all twenty miRNAs. A PPI network was constructed that consisted of 956 nodes and 1298 edges. Four significant modules, consisting of 66 hub genes, were detected from the PPI system via MCODE. Functional enrichment demonstrated that miRNAs have a vital function in cancer development and advancement. CONCLUSION: In summary, our study identified DEMs in HCC tissue, major target genes and possible molecular mechanisms that underlie HCC, providing novel insights for treatment approaches.


Assuntos
Carcinoma Hepatocelular/genética , Neoplasias Hepáticas/genética , MicroRNAs/genética , Transcriptoma/genética , Biomarcadores Tumorais/genética , Biologia Computacional , Humanos , Análise de Sequência com Séries de Oligonucleotídeos
19.
Polymers (Basel) ; 12(4)2020 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-32252274

RESUMO

Two types of naphthalimide derivatives were synthesized by introducing a carbazole group and an n-butyl, respectively, into the naphthalimide system. The electron-donating ability of two kinds of derivatives was investigated by the electrochemical method. These two types of derivatives were used as initiators for the polymerization of d and l-lactide polymerization. Here, the emission and UV-vis absorption serve as the main focus. Compared with solely donor-initiated polylactide (PLA), the PLA with a donor-acceptor structure has a more efficient phosphorescence emission, of which the longest phosphorescence lifetime is up to 407 ms. The experimental results reveal the existence of charge-transfer states in the donor-acceptor-ended polymer. Due to the role of charge-transfer states, a red phosphorescent polymer was developed. Theoretically, these desirable advantages render synthesized PLAs a potential candidate for bioimaging and anti-counterfeiting.

20.
Gastroenterol Res Pract ; 2020: 7246895, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32190043

RESUMO

Background: Periampullary tumors (PT) may rarely present as acute pancreatitis (AP) or acute recurrent pancreatitis (ARP). Unlike other cases of AP and ARP, these conditions necessitate pancreaticoduodenectomy (PD), and timely diagnosis is crucial. Materials and Methods. A retrospective review of clinical, radiological, surgical, and pathological data was conducted for patients admitted to the Binzhou Medical University Hospital during the period from January 2010 to December 2017, for AP or ARP caused by PT. All patients included in the study group had undergone PD. The perioperative data for these patients was compared with data for patients with PT but without AP or ARP who underwent PD during the same period (control group). Results: During the study period, 412 patients with AP or ARP were treated; among this group, 15 patients had PT. Compared with controls, patients in the study group were younger in age and had a longer course of disease, more frequent hospitalizations, and more severe derangements in laboratory data (P < 0.05). Operative time and intraoperative blood loss were significantly higher in the study group, but the incidence of postoperative outcomes such as pancreatic/biliary fistula, abdominal infection, postoperative hospital stay, and mortality were similar between groups (P < 0.05). Operative time and intraoperative blood loss were significantly higher in the study group, but the incidence of postoperative outcomes such as pancreatic/biliary fistula, abdominal infection, postoperative hospital stay, and mortality were similar between groups (. Conclusions: Neither AP nor ARP has any adverse impact on the outcomes of PD. However, in the treatment of younger patients suffering from AP or ARP, unexplained pancreatic duct dilation and weight loss should raise the suspicion of PT. EUS and EUS-FNA may be helpful in making the diagnosis.

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