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1.
World J Gastrointest Oncol ; 13(10): 1506-1517, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34721781

RESUMO

BACKGROUND: Tubular adenocarcinoma of the colon, which originates from the epithelium of the glands, is a major health concern worldwide. However, it is difficult to detect at an early stage. The lack of biomarkers is a main barrier to the diagnosis and treatment of tubular adenocarcinoma. Neutrophil gelatinase-associated lipocalin (NGAL) is a secreted protein that induces the expression of matrix metalloproteinase-9 (MMP-9) and is involved in various tumors. NGAL and MMP-9 have been reported to be associated with tumorigenesis and development. They may have potential as biomarkers for diagnosis of tubular adenocarcinoma of the colon. AIM: To determine whether NGAL and MMP-9 can be used as potential biomarkers to indicate the progression of tubular adenocarcinoma of the colon. METHODS: Samples were collected from surgically excised tissue from various patients. The content of pro-gastrin-releasing peptide (pro-GRP) in the serum was measured by an electrochemiluminescence immunoassay. The expression patterns of NGAL and MMP-9 and the relationship between NGAL and MMP-9 were examined by quantitative real-time PCR, Western blotting and immunohistochemical analysis. RESULTS: In this study, we found that NGAL and MMP-9 can be used as biomarkers for the detection of tubular adenocarcinoma of the colon and that their combination improved diagnostic accuracy. By analyzing the expression of NGAL in tubular adenocarcinoma at different levels, we found that NGAL expression was significantly upregulated in primary tubular adenocarcinoma tissues compared with normal tissues. The upregulation of NGAL expression was strongly correlated with both the degree of differentiation and the disease stage (I-III), indicating that NGAL could serve as a diagnostic biomarker for tubular adenocarcinoma. When using NGAL as a biomarker for diagnosis, the accuracy was similar to that achieved with the widely used biomarker pro-GRP, suggesting that NGAL is reliable. Moreover, the expression of MMP-9 was also strongly correlated with the differentiation stage, demonstrating that MMP-9 could be used as a biomarker to indicate the progression of tubular adenocarcinoma of the colon. More importantly, the combination of NGAL and MMP-9 produced a more accurate diagnosis of tubular adenocarcinoma, and these results were further confirmed by immunohistochemical analysis of tissue sections. CONCLUSION: Our study demonstrated that both NGAL and MMP-9 can be used as biomarkers for the diagnosis of colon tubular adenocarcinoma and that the results could be further improved by combining them.

2.
Artigo em Inglês | MEDLINE | ID: mdl-34626218

RESUMO

Hubs in the brain network are the regions with high centrality and are crucial in the network communication and information integration. Patients with schizophrenia (SCZ) exhibit wide range of abnormality in the hub regions and their connected functional connectivity (FC) at the whole-brain network level. Study of the hubs in the brain networks supporting complex social behavior (social brain network, SBN) would contribute to understand the social dysfunction in patients with SCZ. Forty-nine patients with SCZ and 27 healthy controls (HC) were recruited to undertake the resting-state magnetic resonance imaging scanning and completed a social network (SN) questionnaire. The resting-state SBN was constructed based on the automatic analysis results from the NeuroSynth. Our results showed that the left temporal lobe was the only hub of SBN, and its connected FCs strength was higher than the remaining FCs in both two groups. SCZ patients showed the lower association between the hub-connected FCs (compared to the FCs not connected to the hub regions) with the real-life SN characteristics. These results were replicated in another independent sample (30 SCZ and 28 HC). These preliminary findings suggested that the hub-connected FCs of SBN in SCZ patients exhibit the abnormality in predicting real-life SN characteristics.

3.
Lupus ; 30(11): 1819-1828, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34569384

RESUMO

OBJECTIVES: Caveolin family proteins, including caveolin-1 (Cav-1), caveolin-2 (Cav-2), and caveolin-3 (Cav-3), are identified as the principal protein components of caveolae in mammalian cells. Circulating form of caveolin family proteins can be used as a good potential biomarker for predicting disease. METHODS: To investigate the clinical significance of the serological levels of caveolin family proteins in patients with systemic lupus erythematosus (SLE), we evaluated the soluble serum levels of caveolin family proteins in patients with SLE by enzyme-linked immunosorbent assay (ELISA) and assessed their associations with various known clinical variables. RESULTS: The major findings of our study are as follows: Cav-2 was not detected in serum of SLE patients and normal controls (NCs). Serum Cav-1 and Cav-3 levels were higher in SLE patients compared with NCs. There were no significant correlations between serum Cav-1 and Cav-3 levels and SLE disease activity. Further analysis showed that serum Cav-3 may be more valuable as a marker than serum Cav-1 in SLE patients. CONCLUSION: Serum levels of Cav-1 and Cav-3 might have a diagnostic role in patients with SLE. However, their predictive and prognostic value was not determined. Further studies are necessary to determine the potential clinical significance of these assays in SLE.

4.
Psychiatry Res Neuroimaging ; 317: 111390, 2021 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-34537603

RESUMO

Social anhedonia (SA) impairs social functioning in schizophrenia. Previous evidence suggested that certain brain regions predict longitudinal change of real-world social outcomes, yet previous study designs have failed to capture the corresponding functional connectivity among the brain regions involved. This study measured the real-world social network in 22 pairs of individuals with high and low levels of SA, and followed up them for 21 months. We further explored whether resting-state social brain network characteristics could predict the longitudinal variations of real-world social network. Our results showed that social brain network characteristics could predict the change of real-world social networks in both the high SA and low SA groups. However, the results differed between the two groups, i.e., the topological characteristics of the social brain network predicted real-world social network change in the high SA group; whereas the functional connectivity within the social brain network predicted real-world social network change in the low SA group. Principal component analysis and linear regression analysis on the entire sample showed that the functional connectivity component centered at the right orbital inferior frontal gyrus could best predict social network change. Our findings support the notion that social brain network characteristics could predict social network development.

5.
Artigo em Inglês | MEDLINE | ID: mdl-34282469

RESUMO

Empathy is the ability to generate emotional responses (i.e., cognitive empathy) and to make cognitive inferences (i.e., affective empathy) to other people's emotions. Empirical evidence suggests that patients with bipolar disorder (BD) exhibit impairment in cognitive empathy, but findings on affective empathy are inconsistent. Few studies have examined the neural mechanisms of cognitive and affective empathy in patients with BD. In this study, we examined the empathy-related resting-state functional connectivity (rsFC) in BD patients. Thirty-seven patients with BD and 42 healthy controls completed the self-report Questionnaires of Cognitive and Affective Empathy (QCAE), the Yoni behavioural task, and resting-sate fMRI brain scans. Group comparison of empathic ability was conducted. The interactions between group and empathic ability on seed-based whole brain rsFC were examined. BD patients scored lower on the Online Simulation subscale of the QCAE and showed positive correlations between cognitive empathy and the rsFC of the dorsal Medial Prefrontal Cortex (dmPFC) with the lingual gyrus. The correlations between cognitive empathy and the rsFC of the temporal-parietal junction (TPJ) with the fusiform gyrus, the cerebellum and the parahippocampus were weaker in BD patients than that in healthy controls. These findings highlight the underlying neural mechanisms of empathy impairments in BD patients.

6.
Asian J Psychiatr ; 61: 102671, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33984618

RESUMO

Schizotypy is the latent personality reflecting the liability to schizophrenia. The Multidimensional Schizotypy Scale (MSS) is a newly developed questionnaire to measure the levels of schizotypy. The Chinese version of MSS has been developed and previous findings supported its structure validity. The present study aimed to examine the construct validity of the Chinese version of the MSS by correlating it with the Schizotypal Personality Questionnaire (SPQ). A total of 1359 university students completed the MSS and the SPQ online. The results of 1027 valid participants demonstrated that all MSS dimensions showed good internal consistency. The MSS positive dimension is strongly correlated with SPQ cognitive-perceptual factor, the MSS negative dimension with the SPQ interpersonal factor, and the MSS disorganized dimension with the SPQ disorganized factor. Taken together, our study provides evidence for construct validity of the Chinese version of the MSS.


Assuntos
Transtorno da Personalidade Esquizotípica , China , Análise Fatorial , Humanos , Psicometria , Reprodutibilidade dos Testes , Transtorno da Personalidade Esquizotípica/diagnóstico , Inquéritos e Questionários
7.
Artigo em Inglês | MEDLINE | ID: mdl-33987711

RESUMO

Altered interoception has been consistently found in people with autism spectrum disorder (ASD), and this impairment may contribute to social cognitive dysfunctions. However, little is known regarding the intercorrelations between interoceptive sensibility, autistic, alexithymic, empathic, and self-related traits. We recruited 1360 non-clinical college students and adults to investigate the complex inter-relationship between these variables using network analysis. The resultant network revealed patterns connecting autistic traits to interoceptive sensibility, empathy, alexithymia, and self-awareness, with reasonable stability and test-retest consistency. The node of alexithymia exhibited the highest centrality and expected influence. As revealed by the network comparison test, networks constructed in high- and low-autistic subgroups were comparable in global strength and structure. Our findings suggested that alexithymia serves as an important node, bridging interoceptive deficits, self-awareness, and empathic impairments of autism spectrum disorder. The co-morbidity of alexithymia should be considered carefully in future studies of interoceptive impairments and social deficits in ASD.

8.
Schizophr Res ; 232: 77-84, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34044349

RESUMO

Social behaviour requires the brain to efficiently integrate multiple social processes, but it is not clear what neural substrates underlie general social behaviour. While psychosis patients and individuals with subclinical symptoms are characterized by social dysfunction, the neural mechanisms underlying social dysfunctions in schizophrenia spectrum disorders remains unclear. We first constructed a general social brain network (SBN) using resting-state functional connectivity (FC) with regions of interest based on the automatic meta-analysis results from NeuroSynth. We then examined the general SBN and its relationship with social network (SN) characteristics in 30 individuals with schizophrenia (SCZ) and 33 individuals with social anhedonia (SA). We found that patients with SCZ exhibited deficits in their SN, while SA individuals did not. SCZ patients showed decreased segregation and functional connectivity in their SBN, while SA individuals showed a reversed pattern with increased segregation and functional connectivity of their SBN. Sparse canonical correlation analysis showed that both SCZ patients and SA individuals exhibited reduced correlation between SBN and SN characteristics compared with their corresponding healthy control groups. These preliminary findings suggest that both SCZ and SA participants exhibit abnormality in segregation and functional connectivity within the general SBN and reduced correlation with SN characteristics. These findings could guide the development of non-pharmacological interventions for social dysfunction in SCZ spectrum disorders.


Assuntos
Esquizofrenia , Anedonia , Encéfalo/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Rede Social
9.
Cogn Neuropsychiatry ; 25(6): 466-479, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-33172340

RESUMO

INTRODUCTION: Alteration of empathy is common in patients with psychiatric disorders. Reliable and valid assessment tools for measuring empathy of clinical samples is needed. The Questionnaire of Cognitive and Affective Empathy (QCAE) is a newly-developed instrument to capture cognitive and affective components of empathy. This study aimed to validate the QCAE and compared self-reported empathy between clinical groups with varied psychiatric diagnoses and healthy sample. METHODS: The present study performed factor analysis for the QCAE on clinical samples in the Chinese setting (n = 534), including patients with schizophrenia (n = 158), bipolar disorder (n = 213) and major depressive disorder (n = 163). Internal consistency, internal correlation and convergent validity was examined in the subsample (n = 361). Group comparison among patients with schizophrenia, bipolar disorder, major depressive disorder and healthy controls (n = 107) was conducted to assess the discriminant validity. RESULTS: Our results indicated acceptable factor model, good reliability and validity of the QCAE. Impaired cognitive empathy was found in clinical samples, especially in patients with schizophrenia, while higher affective empathy was found in patients with bipolar disorder and major depressive disorder. CONCLUSION: The QCAE is a useful tool in assessing empathy in patients with varied psychiatric diagnoses.


Assuntos
Transtorno Bipolar , Transtorno Depressivo Maior , Esquizofrenia , Cognição , Empatia , Humanos , Psicometria/métodos , Reprodutibilidade dos Testes , Inquéritos e Questionários
10.
Psychiatry Res Neuroimaging ; 305: 111170, 2020 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-32836136

RESUMO

In this study, we examined differences in resting-state functional connectivity between sub-regions of the Default Mode Network (DMN) and whole brain voxels in 22 individuals with high schizo-obsessive traits (SOT), 30 with high schizotypal traits (SCT) alone, 20 with high obsessive-compulsive traits (OCT) alone and 30 with low trait scores (LT). We found that the SOT group showed the most reduced functional connectivity within the DMN compared with the other groups. The SOT group also showed increased connectivity between the DMN and the Salience Network, and between the DMN and the Auditory Network compared with the LT group. The SCT group exhibited increased connectivity between the DMN and the Salience Network, and between the DMN and the Executive Control Network (ECN) compared with the LT group. The OCT group exhibited decreased connectivity within the DMN, between the DMN and the Salience Network, and between the DMN and the ECN compared with the LT group. These findings highlight different changes in DMN-related functional connectivity associated with high SOT, SCT and OCT traits and may provide insight into the dysfunctional brain networks in the early stage of schizophrenia spectrum disorders.

11.
Psychol Med ; : 1-10, 2020 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-32677599

RESUMO

BACKGROUND: Schizotypy refers to schizophrenia-like traits below the clinical threshold in the general population. The pathological development of schizophrenia has been postulated to evolve from the initial coexistence of 'brain disconnection' and 'brain connectivity compensation' to 'brain connectivity decompensation'. METHODS: In this study, we examined the brain connectivity changes associated with schizotypy by combining brain white matter structural connectivity, static and dynamic functional connectivity analysis of diffusion tensor imaging data and resting-state functional magnetic resonance imaging data. A total of 87 participants with a high level of schizotypal traits and 122 control participants completed the experiment. Group differences in whole-brain white matter structural connectivity probability, static mean functional connectivity strength, dynamic functional connectivity variability and stability among 264 brain sub-regions of interests were investigated. RESULTS: We found that individuals with high schizotypy exhibited increased structural connectivity probability within the task control network and within the default mode network; increased variability and decreased stability of functional connectivity within the default mode network and between the auditory network and the subcortical network; and decreased static mean functional connectivity strength mainly associated with the sensorimotor network, the default mode network and the task control network. CONCLUSIONS: These findings highlight the specific changes in brain connectivity associated with schizotypy and indicate that both decompensatory and compensatory changes in structural connectivity within the default mode network and the task control network in the context of whole-brain functional disconnection may be an important neurobiological correlate in individuals with high schizotypy.

12.
Cancer Biomark ; 29(3): 307-315, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32716348

RESUMO

BACKGROUND: Tribbles pseudokinase 3 (TRIB3) is a member of the tribbles-related family, which is involved a lot of cellular processes and multiple cancers, such as breast cancer, colorectal cancer, renal cell carcinomas, and lung cancer. However, the expression pattern and biological function of TRIB3 in hepatocellular carcinoma (HCC) has not yet been completely elucidated. METHODS: The expression of TRIB3 and clinicopathological characteristics were evaluated by HCC tissue microarray and qPCR analysis. Lentivirus packaging and transfection were employed to establish cell lines with TRIB3 overexpression or knockdown. The biological functions of TRIB3 in the growth of HCC were determined using MTT and crystal violet assays. Tumor growth was monitored in a xenograft model in vivo. RESULTS: The expression of TRIB3 was upregulated in HCC tissue samples compared to paired normal tissues in 45 patients examined by qPCR assay. TRIB3 expression was significantly correlated with HCC tumor size and prognosis in postoperative patients by analysis of the TRIB3 expression data and HCC clinical features. Forced expression of TRIB3 significantly promoted HCC growth in vitro. In contrast, downregulation of TRIB3 inhibited cell growth in vitro. Moreover, knockdown of TRIB3 suppressed tumorigenesis of HCC cells in vivo. CONCLUSION: TRIB3 promotes growth abilities of HCC cells both in vitro and in vivo and predicts poor prognosis of HCC patients, which serves as a prognostic marker and might provide a potential therapeutic candidate for patients with HCC.


Assuntos
Biomarcadores Tumorais/metabolismo , Carcinoma Hepatocelular/genética , Proteínas de Ciclo Celular/metabolismo , Neoplasias Hepáticas/genética , Recidiva Local de Neoplasia/epidemiologia , Proteínas Repressoras/metabolismo , Animais , Biomarcadores Tumorais/análise , Biomarcadores Tumorais/genética , Carcinogênese/genética , Carcinoma Hepatocelular/mortalidade , Carcinoma Hepatocelular/patologia , Carcinoma Hepatocelular/terapia , Proteínas de Ciclo Celular/análise , Proteínas de Ciclo Celular/genética , Linhagem Celular Tumoral , Intervalo Livre de Doença , Feminino , Perfilação da Expressão Gênica , Regulação Neoplásica da Expressão Gênica , Técnicas de Silenciamento de Genes , Hepatectomia , Humanos , Imuno-Histoquímica , Estimativa de Kaplan-Meier , Fígado/patologia , Fígado/cirurgia , Neoplasias Hepáticas/mortalidade , Neoplasias Hepáticas/patologia , Masculino , Camundongos , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/genética , Prognóstico , /genética , Radioterapia Adjuvante , Proteínas Repressoras/análise , Proteínas Repressoras/genética , Análise Serial de Tecidos , Ensaios Antitumorais Modelo de Xenoenxerto
13.
Asian J Psychiatr ; 52: 102096, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32315977

RESUMO

Altered brain structures have been found in patients with schizo-obsessive disorder, schizophrenia and obsessive-compulsive disorder in previous studies. However, it is unclear whether similar brain changes are also found in individuals with high schizo-obsessive traits (SOT), high schizotypal traits (SCT) and obsessive-compulsive symptoms (OCS). We examined grey matter volume (GMV) and white matter integrity (WMI, including fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity) in 26 individuals with high SOT, 30 individuals with high SCT, 25 individuals with OCS and 30 individuals with low trait scores (LT) in this study. Correlation analysis between GMV, WMI, Schizotypal Personality Questionnaire (SPQ) scores and Obsessive-Compulsive Inventory-Revised (OCI-R) scores in the subclinical groups was also carried out. We found that the SOT group exhibited increased GMV at the right superior occipital gyrus and the left postcentral gyrus compared with the LT group. The SCT group exhibited increased GMV at the right precentral gyrus and the bilateral cuneus compared with the LT group, and decreased fractional anisotropy at the anterior corona radiata compared with the other three groups. The OCS group exhibited increased GMV at the left superior temporal gyrus and decreased GMV at the left pre-supplementary motor area compared with the LT group. These findings highlight specific brain changes in individuals with high SOT, high SCT and OCS, and may thus provide new insights into the neurobiological changes that occur in sub-clinical populations of these disorders.


Assuntos
Transtorno Obsessivo-Compulsivo , Esquizofrenia , Substância Branca , Encéfalo/diagnóstico por imagem , Substância Cinzenta/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética , Transtorno Obsessivo-Compulsivo/diagnóstico por imagem , Esquizofrenia/diagnóstico por imagem , Substância Branca/diagnóstico por imagem
14.
Psych J ; 9(1): 150-152, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31290590

RESUMO

The present study aimed to examine the effect of incentive salience on the motivational behavior and pleasure experience of 35 healthy participants during reward pursuits. The findings suggest that high incentive salience promotes motivation in effort-expenditure decision-making, effort exertion, and pleasure experience.


Assuntos
Tomada de Decisões , Motivação , Prazer , Recompensa , Adulto , Feminino , Força da Mão , Voluntários Saudáveis , Humanos , Masculino
15.
Cardiovasc Diagn Ther ; 9(3): 239-249, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31275814

RESUMO

Background: Currently, direct comparative safety between endothelin receptor antagonists (ERAs) in pulmonary arterial hypertension (PAH) is limited. Thus, a systematic review with network analysis was conducted. Methods: An electronic search was performed for randomized controlled trials (RCTs) that reported the interested safety data (abnormal liver function, peripheral edema, and anemia) of ERAs in PAH. Risk ratios (RRs) with their confidence intervals (CIs) and the surface under the cumulative ranking curve (SUCRA) were calculated using a network analysis. Results: Ten RCTs involving 2,288 patients were included. Compared with placebo, bosentan (RR, 2.93; 95% CI, 1.78-4.84) significantly increased the risk of abnormal liver function, ambrisentan (RR, 1.62; 95% CI, 1.23-2.13) significantly increased the risk of peripheral edema, and macitentan (RR, 3.42; 95% CI, 1.65-7.07) significantly increased the risk of anemia. SUCRA analysis suggested that bosentan 125 mg twice daily had the highest risk of abnormal liver function; ambrisentan 10 mg once daily had the highest risk of peripheral edema; macitentan 10 mg once daily had the highest risk of anemia. Conclusions: Abnormal liver function (bosentan), peripheral edema (ambrisentan), and anemia (macitentan) were the safety indicators of ERAs in patients with PAH. Different monitoring parameters should be considered for individual ERA.

16.
Psych J ; 8(4): 401-410, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30623586

RESUMO

Anhedonia is defined as deficits in experiencing everyday life pleasure. Empirical studies suggest that anhedonia and working memory (WM) share overlapping neural substrates. Although WM training has been shown to alleviate anhedonia in individuals with social anhedonia, it is not clear whether WM training may also improve anhedonia in individuals with subsyndromal depression. This study examined the potential effect of WM training on improving anhedonia in college students with subsyndromal depression. Fifty college students were recruited and classified as the depressive (19 students) and non-depressive (31 students) groups according to their scores on the Beck Depression Inventory. They then took part in a 20-session dual n-back WM training. All participants were requested to complete a set of measures capturing experiential pleasure and WM capacity both before and after the training. We found significant improvement in WM performance and self-reported measures of experiential pleasure in both groups. However, only the depressive group showed significant improvement in a computer-based task capturing motivation. These preliminary findings suggest that WM training may be able to alleviate anhedonia in individuals with subsyndromal depressive symptoms.


Assuntos
Anedonia , Depressão/psicologia , Memória de Curto Prazo/fisiologia , Estudantes/estatística & dados numéricos , Inquéritos e Questionários , Adulto , Escalas de Graduação Psiquiátrica Breve , China , Humanos , Universidades , Adulto Jovem
17.
Reprod Biomed Online ; 37(1): 25-32, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29703434

RESUMO

RESEARCH QUESTION: Are miRNAs found in follicular fluid related to blastocyst formation from the corresponding oocytes? DESIGN: In this study, 91 individual follicular fluid samples from single follicles containing mature oocytes from 91 women were collected and classified into group 1 (n = 38) with viable blastocysts, and group 2 (n = 53) with no blastocyst. TaqMan human miRNA cards and quantitative reverse transcription polymerase chain reaction were used to identify differently expressed follicular fluid miRNAs between the two groups. RESULTS: We found MIR-663B to be significantly differentially expressed in follicular fluid of oocytes that yielded viable blastocysts versus those that did not develop into blastocysts (14.16 ± 7.00 versus 23.68 ± 17.02; P = 0.019), as well as for those which develop into blastocysts with good morphology versus those with poor morphology (11.69 ± 3.49 versus 20.16 ± 9.33; P = 0.003). CONCLUSIONS: MIR-663B expression levels in human follicular fluid samples were significantly negatively related to viable blastocyst formation and may become an objective evaluation criterion for embryo development potential after IVF.


Assuntos
Blastocisto/metabolismo , Desenvolvimento Embrionário/genética , Líquido Folicular/metabolismo , MicroRNAs/metabolismo , Adulto , Feminino , Humanos , MicroRNAs/genética , Oócitos/metabolismo , Oogênese/fisiologia , Injeções de Esperma Intracitoplásmicas
18.
Medicine (Baltimore) ; 97(11): e0122, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29538209

RESUMO

BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive disease and ultimately leads to right heart failure. Endothelin receptor antagonists (ERAs) have been demonstrated to significantly improve prognosis in PAH. However, ERAs-induced side effects can result in poor patient tolerance. Thus, we aim to evaluate current safety evidence of ERAs in PAH. METHODS: An electronic search will be performed for randomized controlled trials (RCTs) that reported the interested safety data (abnormal liver function, peripheral edema, and anemia) of ERAs in PAH. Risk ratios (RRs) with their confidence intervals (CIs) and the surface under the cumulative ranking curve (SUCRA) will be calculated using a network analysis. RESULTS: This study will provide the safety evidence of ERAs in PAH by combining the results of individual studies based on direct- and network comparison, and to rank ERAs in the evidence network. CONCLUSIONS: The results will supplement missing evidence of head-to-head comparisons between different ERAs and guide both clinical decision-making and future research.


Assuntos
Antagonistas dos Receptores de Endotelina/farmacologia , Insuficiência Cardíaca/prevenção & controle , Hipertensão Pulmonar/tratamento farmacológico , Anti-Hipertensivos/farmacologia , Insuficiência Cardíaca/etiologia , Humanos , Hipertensão Pulmonar/complicações , Metanálise em Rede , Projetos de Pesquisa , Resultado do Tratamento
19.
Environ Entomol ; 46(3): 538-543, 2017 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-28398551

RESUMO

Knowledge about the prey preference of polyphagous predators is important for determining their ability to suppress pest insects. Tetranychus truncatus (Tetranychidae), Tetranychus turkestani (Tetranychidae), and Thrips tabaci (Thripidae) often coexist in crops. Neoseiulus bicaudus (Wainstein) is a native predatory mite that was recently observed in the Xinjiang Uygur Autonomous Region of northwest China. The objective of this study was to assess the potential of N. bicaudus as a bio-control agent against the three pest species mentioned above. The results showed that N. bicaudus protonymphs, deutonymphs, and adults can be effective biological control agents for the three pest species. Neoseiulus bicaudus at all three developmental stages exhibited a Holling's Type II (convex) functional response to the prey. Neoseiulus bicaudus exhibited no preference between T. truncatus adults and T. turkestani adults, irrespective of the prey ratio. In comparison, N. bicaudus clearly preferred first-instar T. tabaci larvae to T. turkestani adults. The results of this study suggest that N. bicaudus could help control T. truncatus, T. turkestani, and T. tabaci. Among these pests, N. bicaudus may be most effective for first-instar T. tabaci.


Assuntos
Ácaros/fisiologia , Controle Biológico de Vetores , Comportamento Predatório , Animais , China , Feminino , Cadeia Alimentar , Larva/crescimento & desenvolvimento , Larva/fisiologia , Ácaros/crescimento & desenvolvimento , Ninfa/crescimento & desenvolvimento , Ninfa/fisiologia , Tetranychidae/crescimento & desenvolvimento , Tetranychidae/fisiologia , Tisanópteros/crescimento & desenvolvimento , Tisanópteros/fisiologia
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