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1.
Asian J Psychiatr ; 52: 102096, 2020 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-32315977

RESUMO

Altered brain structures have been found in patients with schizo-obsessive disorder, schizophrenia and obsessive-compulsive disorder in previous studies. However, it is unclear whether similar brain changes are also found in individuals with high schizo-obsessive traits (SOT), high schizotypal traits (SCT) and obsessive-compulsive symptoms (OCS). We examined grey matter volume (GMV) and white matter integrity (WMI, including fractional anisotropy, mean diffusivity, axial diffusivity and radial diffusivity) in 26 individuals with high SOT, 30 individuals with high SCT, 25 individuals with OCS and 30 individuals with low trait scores (LT) in this study. Correlation analysis between GMV, WMI, Schizotypal Personality Questionnaire (SPQ) scores and Obsessive-Compulsive Inventory-Revised (OCI-R) scores in the subclinical groups was also carried out. We found that the SOT group exhibited increased GMV at the right superior occipital gyrus and the left postcentral gyrus compared with the LT group. The SCT group exhibited increased GMV at the right precentral gyrus and the bilateral cuneus compared with the LT group, and decreased fractional anisotropy at the anterior corona radiata compared with the other three groups. The OCS group exhibited increased GMV at the left superior temporal gyrus and decreased GMV at the left pre-supplementary motor area compared with the LT group. These findings highlight specific brain changes in individuals with high SOT, high SCT and OCS, and may thus provide new insights into the neurobiological changes that occur in sub-clinical populations of these disorders.

2.
Psych J ; 9(1): 150-152, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31290590

RESUMO

The present study aimed to examine the effect of incentive salience on the motivational behavior and pleasure experience of 35 healthy participants during reward pursuits. The findings suggest that high incentive salience promotes motivation in effort-expenditure decision-making, effort exertion, and pleasure experience.

3.
Cardiovasc Diagn Ther ; 9(3): 239-249, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31275814

RESUMO

Background: Currently, direct comparative safety between endothelin receptor antagonists (ERAs) in pulmonary arterial hypertension (PAH) is limited. Thus, a systematic review with network analysis was conducted. Methods: An electronic search was performed for randomized controlled trials (RCTs) that reported the interested safety data (abnormal liver function, peripheral edema, and anemia) of ERAs in PAH. Risk ratios (RRs) with their confidence intervals (CIs) and the surface under the cumulative ranking curve (SUCRA) were calculated using a network analysis. Results: Ten RCTs involving 2,288 patients were included. Compared with placebo, bosentan (RR, 2.93; 95% CI, 1.78-4.84) significantly increased the risk of abnormal liver function, ambrisentan (RR, 1.62; 95% CI, 1.23-2.13) significantly increased the risk of peripheral edema, and macitentan (RR, 3.42; 95% CI, 1.65-7.07) significantly increased the risk of anemia. SUCRA analysis suggested that bosentan 125 mg twice daily had the highest risk of abnormal liver function; ambrisentan 10 mg once daily had the highest risk of peripheral edema; macitentan 10 mg once daily had the highest risk of anemia. Conclusions: Abnormal liver function (bosentan), peripheral edema (ambrisentan), and anemia (macitentan) were the safety indicators of ERAs in patients with PAH. Different monitoring parameters should be considered for individual ERA.

4.
Psych J ; 8(4): 401-410, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30623586

RESUMO

Anhedonia is defined as deficits in experiencing everyday life pleasure. Empirical studies suggest that anhedonia and working memory (WM) share overlapping neural substrates. Although WM training has been shown to alleviate anhedonia in individuals with social anhedonia, it is not clear whether WM training may also improve anhedonia in individuals with subsyndromal depression. This study examined the potential effect of WM training on improving anhedonia in college students with subsyndromal depression. Fifty college students were recruited and classified as the depressive (19 students) and non-depressive (31 students) groups according to their scores on the Beck Depression Inventory. They then took part in a 20-session dual n-back WM training. All participants were requested to complete a set of measures capturing experiential pleasure and WM capacity both before and after the training. We found significant improvement in WM performance and self-reported measures of experiential pleasure in both groups. However, only the depressive group showed significant improvement in a computer-based task capturing motivation. These preliminary findings suggest that WM training may be able to alleviate anhedonia in individuals with subsyndromal depressive symptoms.


Assuntos
Anedonia , Depressão/psicologia , Memória de Curto Prazo/fisiologia , Estudantes/estatística & dados numéricos , Inquéritos e Questionários , Adulto , Escalas de Graduação Psiquiátrica Breve , China , Humanos , Universidades , Adulto Jovem
5.
Reprod Biomed Online ; 37(1): 25-32, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29703434

RESUMO

RESEARCH QUESTION: Are miRNAs found in follicular fluid related to blastocyst formation from the corresponding oocytes? DESIGN: In this study, 91 individual follicular fluid samples from single follicles containing mature oocytes from 91 women were collected and classified into group 1 (n = 38) with viable blastocysts, and group 2 (n = 53) with no blastocyst. TaqMan human miRNA cards and quantitative reverse transcription polymerase chain reaction were used to identify differently expressed follicular fluid miRNAs between the two groups. RESULTS: We found MIR-663B to be significantly differentially expressed in follicular fluid of oocytes that yielded viable blastocysts versus those that did not develop into blastocysts (14.16 ± 7.00 versus 23.68 ± 17.02; P = 0.019), as well as for those which develop into blastocysts with good morphology versus those with poor morphology (11.69 ± 3.49 versus 20.16 ± 9.33; P = 0.003). CONCLUSIONS: MIR-663B expression levels in human follicular fluid samples were significantly negatively related to viable blastocyst formation and may become an objective evaluation criterion for embryo development potential after IVF.


Assuntos
Blastocisto/metabolismo , Desenvolvimento Embrionário/genética , Líquido Folicular/metabolismo , MicroRNAs/metabolismo , Adulto , Feminino , Humanos , MicroRNAs/genética , Oócitos/metabolismo , Oogênese/fisiologia , Injeções de Esperma Intracitoplásmicas
6.
Medicine (Baltimore) ; 97(11): e0122, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29538209

RESUMO

BACKGROUND: Pulmonary arterial hypertension (PAH) is a progressive disease and ultimately leads to right heart failure. Endothelin receptor antagonists (ERAs) have been demonstrated to significantly improve prognosis in PAH. However, ERAs-induced side effects can result in poor patient tolerance. Thus, we aim to evaluate current safety evidence of ERAs in PAH. METHODS: An electronic search will be performed for randomized controlled trials (RCTs) that reported the interested safety data (abnormal liver function, peripheral edema, and anemia) of ERAs in PAH. Risk ratios (RRs) with their confidence intervals (CIs) and the surface under the cumulative ranking curve (SUCRA) will be calculated using a network analysis. RESULTS: This study will provide the safety evidence of ERAs in PAH by combining the results of individual studies based on direct- and network comparison, and to rank ERAs in the evidence network. CONCLUSIONS: The results will supplement missing evidence of head-to-head comparisons between different ERAs and guide both clinical decision-making and future research.


Assuntos
Antagonistas dos Receptores de Endotelina/farmacologia , Insuficiência Cardíaca/prevenção & controle , Hipertensão Pulmonar/tratamento farmacológico , Anti-Hipertensivos/farmacologia , Insuficiência Cardíaca/etiologia , Humanos , Hipertensão Pulmonar/complicações , Metanálise em Rede , Projetos de Pesquisa , Resultado do Tratamento
7.
Environ Entomol ; 46(3): 538-543, 2017 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-28398551

RESUMO

Knowledge about the prey preference of polyphagous predators is important for determining their ability to suppress pest insects. Tetranychus truncatus (Tetranychidae), Tetranychus turkestani (Tetranychidae), and Thrips tabaci (Thripidae) often coexist in crops. Neoseiulus bicaudus (Wainstein) is a native predatory mite that was recently observed in the Xinjiang Uygur Autonomous Region of northwest China. The objective of this study was to assess the potential of N. bicaudus as a bio-control agent against the three pest species mentioned above. The results showed that N. bicaudus protonymphs, deutonymphs, and adults can be effective biological control agents for the three pest species. Neoseiulus bicaudus at all three developmental stages exhibited a Holling's Type II (convex) functional response to the prey. Neoseiulus bicaudus exhibited no preference between T. truncatus adults and T. turkestani adults, irrespective of the prey ratio. In comparison, N. bicaudus clearly preferred first-instar T. tabaci larvae to T. turkestani adults. The results of this study suggest that N. bicaudus could help control T. truncatus, T. turkestani, and T. tabaci. Among these pests, N. bicaudus may be most effective for first-instar T. tabaci.


Assuntos
Ácaros/fisiologia , Controle Biológico de Vetores , Comportamento Predatório , Animais , China , Feminino , Cadeia Alimentar , Larva/crescimento & desenvolvimento , Larva/fisiologia , Ácaros/crescimento & desenvolvimento , Ninfa/crescimento & desenvolvimento , Ninfa/fisiologia , Tetranychidae/crescimento & desenvolvimento , Tetranychidae/fisiologia , Tisanópteros/crescimento & desenvolvimento , Tisanópteros/fisiologia
9.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 28(1): 39-44, 50, 2016 Feb.
Artigo em Chinês | MEDLINE | ID: mdl-27356403

RESUMO

OBJECTIVE: To establish a novel convenient loop-mediated isothermal amplification (LAMP) method with the unique genes coding Plasmodium helical interspersed sub-telomeric superfamily (PHIST) for the rapid molecular diagnosis of P. falciparum. METHODS: The unique genes coding PHIST with high expression mRNA profile during the ring form or schizont period of P. falciparum were screened and selected from the PlasmoDB database. The LAMP primers of targeted genes were designed by the online software (PrimerExplorer V4). The LAMP assay was executed by the color-displaying method with SYBR Green. The dried blood spots of P. falciparum from clinical isolates were collected and the genomic DNA (gDNA) was extracted. For evaluation of sensitivity, the gDNA was diluted to four gradients (10⁻¹, 10⁻², 10⁻³, and 10⁻4). For assessment of specificity, the gDNA (s) of P. vivax, P. yoelii, Taenia saginata, and Schistosoma japonicum were also extracted. RESULTS: Totally, 61 P. falciparum unique genes coding PHIST were found. The PF3D7_1372300 with high expression value during the ring form and PF3D7_1401600 with high expression value during the schizont period were selected for LAMP assay. The lowest detectable limits of PF3D7_1372300 and PF3D7_1401600 were 130.5 parasite/µl and 1305.3 parasite/µL, respectively. Specific tests showed the amplified products of P. falciparum was positive and all the others including P. vivax, P. yoelii, T. saginata, and S. japonicum were negative. CONCLUSIONS: The established LAMP method with PF3D7_1372300 gene is sensitive, specific, simple and useful. It can be applied to the field investigation and clinical diagnosis for falciparum malaria.


Assuntos
Técnicas de Amplificação de Ácido Nucleico/métodos , Plasmodium falciparum/genética , Proteínas de Protozoários/genética , Sequência de Bases , Biologia Computacional , Dados de Sequência Molecular
10.
Plant Physiol ; 168(4): 1417-32, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26145151

RESUMO

Seed development is an important process of reproductive development and consists of embryo and endosperm development; both comprise several key processes. To determine and investigate the functions of the dynamic DNA methylome during seed development, we profiled the DNA methylation genome wide in a series of developmental stages of rice (Oryza sativa) embryo and endosperm by methylcytosine immunoprecipitation followed by Illumina sequencing. The results showed that embryo is hypermethylated predominantly around non-transposable element (TE) genes, short DNA-TEs, and short interspersed TEs compared with endosperm, and non-TE genes have the most diverse methylation status across seed development. In addition, lowly expressed genes are significantly enriched in hypermethylated genes, but not vice versa, confirming the crucial role of DNA methylation in suppressing gene transcription. Further analysis revealed the significantly decreased methylation at early developing stages (from 2 to 3 d after pollination), indicating a predominant role of demethylation during early endosperm development and that genes with a consistent negative correlation between DNA methylation change and expression change may be potentially directly regulated by DNA methylation. Interestingly, comparative analysis of the DNA methylation profiles revealed that both rice indica and japonica subspecies showed robust fluctuant profiles of DNA methylation levels in embryo and endosperm across seed development, with the highest methylation level at 6 d after pollination (2 d after pollination of endosperm in japonica as well), indicating that a complex and finely controlled methylation pattern is closely associated with seed development regulation. The systemic characterization of the dynamic DNA methylome in developing rice seeds will help us understand the effects and mechanism of epigenetic regulation in seed development.


Assuntos
Metilação de DNA , Perfilação da Expressão Gênica , Regulação da Expressão Gênica no Desenvolvimento , Regulação da Expressão Gênica de Plantas , Oryza/genética , Sementes/genética , Elementos de DNA Transponíveis/genética , Endosperma/genética , Endosperma/crescimento & desenvolvimento , Ontologia Genética , Genes de Plantas/genética , Genoma de Planta/genética , Oryza/crescimento & desenvolvimento , Proteínas de Plantas/genética , Sementes/crescimento & desenvolvimento
11.
Asian Pac J Cancer Prev ; 16(9): 3703-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25987025

RESUMO

BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) is a strong predictor of mortality in patients with colorectal, lung, gastric cancer, pancreatic and metastatic renal cell carcinoma. We here evaluated whether preoperative NLR is an independent prognostic factor for non-metastatic renal cell carcinoma (RCC). MATERIALS AND METHODS: Data from 327 patients who underwent curative or palliative nephrectomy were evaluated retrospectively. In preoperative blood routine examination, neutrophils and lymphocytes were obtained. The predictive value of NLR for non-metastatic RCC was analyzed. RESULTS: The NLR of 327 patients was 2.72±2.25. NLR <1.7 and NLR ≥1.7 were classified as low and high NLR groups, respectively. Chi-square test showed that the preoperative NLR was significantly correlated with the tumor size (P=0.025), but not with the histological subtype (P=0.095)and the pT stage (P=0.283). Overall survival (OS) and disease-free survival (DFS) were assessed using the Kaplan-Meier method. Effects of NLR on OS (P=0.007) and DFS (P=0.011) were significant. To evaluate the independent prognostic significance of NLR, multivariate COX regression models were applied and identified increased NLR as an independent prognostic factor for OS (P=0.015), and DFS (P=0.019). CONCLUSIONS: Regarding patient survival, an increased NLR represented an independent risk factor, which might reflect a higher risk for severe cardiovascular and other comorbidities. An elevated blood NLR may be a biomarker of poor OS and DFS in patients with non-metastatic RCC.


Assuntos
Adenocarcinoma/secundário , Carcinoma de Células Renais/secundário , Neoplasias Renais/patologia , Linfócitos/patologia , Nefrectomia/mortalidade , Neutrófilos/patologia , Cuidados Pré-Operatórios , Adenocarcinoma/mortalidade , Adenocarcinoma/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Renais/mortalidade , Carcinoma de Células Renais/cirurgia , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Neoplasias Renais/mortalidade , Neoplasias Renais/cirurgia , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Prognóstico , Estudos Retrospectivos , Taxa de Sobrevida , Adulto Jovem
12.
J Clin Lab Anal ; 29(4): 289-93, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24849556

RESUMO

BACKGROUND: This study aimed to determine the relationship between hematocrit (HCT) levels and cardiovascular risk factors in a community-based population of middle-aged adults. METHODS: From April 2011 to February 2012, a total of 1,884 middle-aged adults were selected from a community-based population in China. Blood and urine samples were collected for routine blood and urine tests, and measurement of plasma glucose and lipid levels. Baseline information including traditional cardiovascular risk factors was obtained by standard questionnaire to analyze. We evaluated the distribution of the HCT values for middle-aged adults with or without cardiovascular risk factors. There were 548 males and 1,336 females in this study. The mean age of all subjects was 54.7 ± 6.7 years. There were 1,209 subjects with risk factors and 675 without risk factors. RESULTS: The HCT levels in subjects with risk factors were higher than those without risk factors (P = 0.005). According to a simplified tool for evaluation of the 10-year risk of ischemic cardiovascular diseases (CVDs) in Chinese populations, all subjects were divided into four groups: the ultralow-risk group (1,367, 72.6%), low-risk group (232, 12.3%), intermediate-risk group (201, 10.7%), and high-risk/ultrahigh-risk group (84, 4.4%). Compared with HCT levels in the ultralow-risk group, significant differences were found in the low-risk, intermediate-risk, and high-risk/ultrahigh-risk groups (all P < 0.05). CONCLUSION: Our results indicate that elevated HCT levels may be positively associated with cardiovascular risk factors. Thus, the combination of HCT values and cardiovascular risk factors may enable early diagnosis of CVDs.


Assuntos
Doenças Cardiovasculares/sangue , Hematócrito , Características de Residência , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco
13.
Exp Toxicol Pathol ; 61(5): 481-90, 2009 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19121570

RESUMO

INTRODUCTION: Sepsis could be initiated by the gastrointestinal tract injury and subsequent bacterial translocation. In the present experiment, we aimed to investigate effect of ulinastatin (UTI) on the small intestinal injury and bacterial translocation in septic rats and role of mast cells degranulation in its action. METHODS: Fifty-four male Wistar rats were randomly divided into three groups: sham laparatomy, cecal ligation and puncture (CLP), and CLP plus UTI. CLP was used to develop septic rat model and UTI was administered to rats intraperitoneally (50,000 U/kg) 30 min prior to CLP operation. After CLP or sham operation, variable parameters were investigated in three subsets of animals. One subset was used for measurements of nitrite and nitrate (NO(x)) concentration in plasma at 1, 6, 12, 18, and 24h and levels of NO(x) and iNOS mRNA in the small intestine, RMCP-II released into the small intestinal lumen, bacterial translocation and morphologic changes at 24h. The other subsets were used for the small intestinal motility and microvascular in vivo at 24h. RESULTS: Bacterial translocation, barrier injury, impaired motility and blood flow, mast cells degranulation of the small intestine in the CLP group were found more severe than that in the sham group. Elevated RMCP-II, NO(x), and iNOS mRNA levels were also detected in the CLP group. Application of UTI not only protected the small intestine from sepsis but also diminished changes of intestinal mast cells. CONCLUSION: UTI can significantly ameliorate the small intestinal injury and subsequent bacterial translocation by inhibiting mast cells degranulation in septic rats.


Assuntos
Degranulação Celular/efeitos dos fármacos , Glicoproteínas/farmacologia , Intestino Delgado/efeitos dos fármacos , Sepse/tratamento farmacológico , Inibidores da Tripsina/farmacologia , Animais , Quimases/metabolismo , Modelos Animais de Doenças , Motilidade Gastrointestinal/efeitos dos fármacos , Intestino Delgado/lesões , Intestino Delgado/patologia , Masculino , Mastócitos/efeitos dos fármacos , Mastócitos/fisiologia , Óxido Nítrico/metabolismo , Óxido Nítrico Sintase Tipo II/metabolismo , RNA Mensageiro/análise , Ratos , Ratos Wistar , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Sepse/patologia , Junções Íntimas/ultraestrutura
15.
Vaccine ; 25(5): 867-76, 2007 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-17005300

RESUMO

The objectives of this research were to evaluate the risk of prolonged testicular infection as a consequence of vaccination of peri-pubertal bulls with a modified-live, noncytopathic strain of BVDV and to assess vaccine efficacy in preventing prolonged testicular infections after a subsequent acute infection. Seronegative, peri-pubertal bulls were vaccinated subcutaneously with an approximate minimum immunizing dose or a 10x standard dose of modified-live, noncytopathic BVDV or were maintained as unvaccinated controls. Forty-nine days after vaccination, all bulls were intranasally inoculated with a noncytopathic field strain of BVDV. Semen and testicular biopsies collected after vaccination and challenge were assayed for BVDV using virus isolation, reverse transcription-nested PCR, or immunohistochemistry and the identity of viral strains was determined by nucleotide sequencing of PCR products. The vaccine strain of BVDV was detected in testicular tissue of vaccinated bulls as long as 134 days after immunization. Prolonged testicular infections with the challenge strain were detected only in unvaccinated bulls as long as 85 days after challenge. Whereas vaccination caused prolonged testicular infection in some bulls, it did prevent subsequent infection of testicular tissue with the challenge strain. This research demonstrates that subcutaneous vaccination of naïve, peri-pubertal bulls with a noncytopathic, modified-live strain of BVDV can result in prolonged viral replication within testicular tissue. The risk for these prolonged testicular infections to cause venereal transmission of BVDV or subfertility is likely to be low but requires further investigation.


Assuntos
Doença das Mucosas por Vírus da Diarreia Viral Bovina/prevenção & controle , Vírus da Diarreia Viral Bovina/imunologia , Testículo/virologia , Vacinas Virais/imunologia , Animais , Anticorpos Antivirais/sangue , Bovinos , Vírus da Diarreia Viral Bovina/isolamento & purificação , Vírus da Diarreia Viral Bovina/fisiologia , Masculino , Maturidade Sexual , Vacinação , Viremia/virologia , Replicação Viral
16.
Pharmacol Biochem Behav ; 83(2): 271-6, 2006 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-16540157

RESUMO

In our previous studies using an elevated plus-maze test in mice, taurine was shown to present an anxiolytic-like effect after single and repeated administration. The aim of the present study was to investigate the anxiolytic and behavioral effects of taurine on rats in the open field, hole-board, and social interaction test compared to the positive control diazepam. Taurine (14, 42, and 126 mg/kg, i.p.) was administered 30 min before the tests. In the social interaction and hole-board tests, taurine (42 mg/kg) significantly increased social interaction time and the number and duration of head-dipping. In the open field test, taurine (126 mg/kg, i.p.) presented anxiolytic-like effects by increasing the number of center entries, time spent in the central area and the anti-thigmotactic score while having no effect on the locomotor activity. Results from these experiments suggest that taurine produces an anxiolytic-like effect in these animal models and may act as a modulator or anti-anxiety agent in the central nervous system.


Assuntos
Ansiedade/psicologia , Comportamento Animal/efeitos dos fármacos , Taurina/farmacologia , Animais , Relações Interpessoais , Masculino , Aprendizagem em Labirinto , Ratos , Ratos Wistar
17.
Life Sci ; 78(3): 232-8, 2005 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-16111714

RESUMO

The present study was designed to investigate the putative anxiolytic-like effect of sinomenine in three experimental models of anxiety in male rats and mice. Use of the elevated plus-maze test revealed that sinomenine (20 and 40 mg/kg, p.o.) increased the percentage of open arm entries and diazepam (2 mg/kg, p.o.) increased the percentage of open arm entries, the percentage of time spent on open arms and total arm entries in mice. In the light/dark transition test, sinomenine (20 and 40 mg/kg, p.o.) increased time spent in the light area and diazepam (2 mg/kg, p.o.) increased time spent in the light area and the overall movements in mice. In the social interaction test, the sinomenine-treated animals significantly increased social interaction time in low light unfamiliar (7 mg/kg, p.o.) and high light unfamiliar conditions (7 and 14 mg/kg, p.o.) as well as diazepam (3 mg/kg, p.o.). Sinomenine (28 mg/kg, p.o.) can also decrease squares entered in rats in social interaction test under low light unfamiliar condition. In the open-field test, sinomenine (160 mg/kg) decreased squares entered in mice. Thus, these findings indicated that sinomenine exhibited anxiolytic-like effect.


Assuntos
Ansiolíticos/uso terapêutico , Ansiedade/tratamento farmacológico , Comportamento Animal/efeitos dos fármacos , Morfinanos/uso terapêutico , Animais , Ansiedade/fisiopatologia , Escuridão , Modelos Animais de Doenças , Relação Dose-Resposta a Droga , Luz , Masculino , Aprendizagem em Labirinto/efeitos dos fármacos , Camundongos , Ratos , Ratos Wistar , Comportamento Social , Especificidade da Espécie
18.
Pharmacol Biochem Behav ; 81(3): 683-7, 2005 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15970315

RESUMO

The present study in mice compared the putative anxiolytic-like effect of paeonol, a phenolic component from the root bark of Paeonia moutan, with the benzodiazepine diazepam in the elevated plus maze and the light/dark box-test. The comparison was also with regard to locomotor activity (open-field test) and myorelaxant potential (inclined plane test). As with 2 mg/kg diazepam, paeonol (at 17.5 mg/kg) increased the percentage of time spent on open arms in the elevated plus maze and increased the time spent in the light area of the light/dark box (at 8.75 and 17.5 mg/kg). Since paeonol, in contrast to diazepam, had no effect on either the number of squares entered in the open-field test or in the inclined plane test, its side-effect profile is considered as superior to the benzodiazepine.


Assuntos
Acetofenonas/farmacologia , Ansiolíticos/farmacologia , Análise de Variância , Animais , Comportamento Animal/efeitos dos fármacos , Escuridão , Diazepam/farmacologia , Relação Dose-Resposta a Droga , Luz , Masculino , Aprendizagem em Labirinto/efeitos dos fármacos , Camundongos , Atividade Motora/efeitos dos fármacos , Relaxantes Musculares Centrais/farmacologia
19.
Pharmacol Biochem Behav ; 79(2): 377-82, 2004 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-15501315

RESUMO

The effects of angelica essential oil in three assays predictive of anxiolytic activity in male mice were studied, with diazepam as a positive anxiolytic control. In the elevated plus-maze test, compared to the positive control diazepam, angelica essential oil (30.0 mg/kg, PO) had a modest anxiolytic-like effect (increased the percentage of open-arm time and reduced the percent protected head dips). In the light/dark test, angelica essential oil (30.0 mg/kg) prolonged the time spent in the light area without altering the locomotor activity of the animals. In the stress-induced hyperthermia test, 60 and 70 min after drug administration, rectal temperature was measured twice, angelica essential oil at the dose of 30.0 mg/kg inhibited stress-induced hyperthermia. Thus, these findings indicate that angelica essential oil, as does diazepam, exhibits an anxiolytic-like effect. Further studies will be required to assess the generality of the present findings to other species and behavioural paradigms.


Assuntos
Angelica sinensis , Ansiolíticos/uso terapêutico , Ansiedade/tratamento farmacológico , Medicamentos de Ervas Chinesas/uso terapêutico , Fitoterapia , Óleos Vegetais/uso terapêutico , Animais , Ansiedade/etiologia , Escuridão , Diazepam/uso terapêutico , Modelos Animais de Doenças , Febre/tratamento farmacológico , Febre/etiologia , Luz , Masculino , Aprendizagem em Labirinto/efeitos dos fármacos , Camundongos , Estresse Fisiológico/complicações
20.
Life Sci ; 75(12): 1503-11, 2004 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-15240184

RESUMO

The effects of taurine, an inhibitory amino acid, on the behavior of male mice were examined in the elevated plus-maze test of anxiety. Acute taurine treatment (60 mg/kg, PO) significantly increased the percentage of time spent in the open arms. Moreover, when taurine was administered daily for seven days and the plus-maze test was conducted 40 minutes after the last administration, a significant increase of the percentage of time in the open arms was observed even at dose of 2.5 mg/kg, however the open arm entries and the total entries were unaffected at any dose tested. In order to get a comprehensive profile of drug action, detailed behavioral analyses were further exerted. Single administration of 60 mg/kg taurine can significantly reduce the total rears. The results suggest that taurine have some anxiolytic-like properties, although its effects seem more limited and are not consistent with those presented by classic anxiolytics, such as diazepam.


Assuntos
Ansiolíticos/farmacologia , Comportamento Animal/efeitos dos fármacos , Atividade Motora/efeitos dos fármacos , Taurina/farmacologia , Análise de Variância , Animais , Diazepam , Relação Dose-Resposta a Droga , Masculino , Camundongos , Fatores de Tempo
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