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1.
Angew Chem Int Ed Engl ; : e202203519, 2022 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-35384199

RESUMO

Inferior contact interface and low charge transfer efficiency seriously restrict the performance of heterojunctions. Herein, chemically bonded α-Fe2 O3 /Bi4 MO8 Cl (M=Nb, Ta) dot-on-plate Z-scheme junctions with strong internal electric field are crafted by an in situ growth route. Experimental and theoretical results demonstrate that the internal electric field provides a powerful driving force for vectorial migration of photocharges between Bi4 MO8 Cl and α-Fe2 O3 , and the interfacial Fe-O bond not only serves as an atomic-level charge flow highway but also lowers the charge transfer energy barrier, thereby accelerating Z-scheme charge transfer and realizing effective spatial charge separation. Impressively, α-Fe2 O3 /Bi4 MO8 Cl manifests a significantly improved photocatalytic activity for selective oxidation of aromatic alcohols into aldehydes (Con. ≥92 %, Sel. ≥96 %), with a performance improvement of one to two orders of magnitude. This work presents atomic-level insight into interfacial charge flow steering.

2.
Small ; 18(19): e2200914, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35403802

RESUMO

Hydrogen peroxide (H2 O2 ) as a useful chemical has a wide range of applications, and the development of efficient semiconducting materials for H2 O2 production is deemed as a promising strategy to realize the energy conversion. In this paper, Cdx Zn1-x S (x = 0, 0.1, 0.3, 0.5, 0.7, 0.9, 1) nano-branches are fabricated and the piezocatalytic and photocatalytic H2 O2 evolution performance are studied. Under ultrasound condition, the H2 O2 yield of as-synthesized solid solutions is all higher than those of pristine ZnS and CdS, and optimal evolution rate achieves 21.9 µmol g-1 h-1 for Cd0.5 Zn0.5 S without any sacrificial agent, while it is increased to 151.6 µmol g-1 h-1 under visible light irradiation. The piezo/photoelectrochemical tests, piezoresponse force microscopy (PFM), and computational simulation reveal that the nano-branch structure benefits the mechanical energy conversion more, favoring the H2 O2 evolution for Cd0.5 Zn0.5 S, and a higher concentration of charge carriers is generated in photocatalysis. The active radical trapping and in situ electron spin resonance (ESR) experiments demonstrate that both of the H2 O2 generation pathways are originated from oxygen reduction by the sequential two-step single-electron reaction. This work opens a door for promoting the H2 O2 production from nanostructure and solid solution design.

3.
SAGE Open Med Case Rep ; 10: 2050313X221082416, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35355852

RESUMO

Ameloblastoma is a kind of benign, odontogenic tumor of epithelial origin, and surgery is mainstay treatment method; however, recurrence is common, and usually the treatment for recurrence is still surgery. We report on a patient of recurrent ameloblastoma treated with carbon ion radiation therapy and achieved a good efficacy. A 25-year-old female with relapse of an ameloblastoma was referred to the Wuwei Heavy Ion Center for carbon ion therapy. She had been initially diagnosed with ameloblastoma 8 years ago and underwent operation of right mandible ameloblastoma. After she transferred to our center, she accepted a dose of 60 GyE carbon ion radiation therapy, and the efficacy is good. Carbon ion radiation therapy can be an effective treatment option for ameloblastoma.

4.
Soft Matter ; 18(13): 2522-2527, 2022 Mar 30.
Artigo em Inglês | MEDLINE | ID: mdl-35311841

RESUMO

The electrochemical performance and safe operation of the separator plays an important role in lithium-ion batteries. The introduction of inorganic nanoparticles into the separators with organic matter as the matrix effectively improves the thermal stability and wettability of the composite separators, but it also blocks some pores and adversely affects the electrochemical performance. Herein, vermiculite and laponite nanoparticles are introduced into a poly(vinylidene fluoride) matrix to prepare organic-inorganic composite separators for lithium-ion batteries and the synergistic effect of the two inorganic nanofillers is explored. By adding the same amount of the two nanoparticles into the polymer matrix, the prepared separator has the highest ionic conductivity (0.72 mS cm-1) at room temperature and the lowest interfacial impedance (283 Ω). It has an initial discharge capacity of 161.2 mA h g-1 at a rate of 0.5C, a coulombic efficiency of 99.5% after 100 cycles, and a high capacity retention rate of 98.4%, which shows excellent rate performance. The results show that the two clay nanoparticles exert their respective advantages and exhibit a synergistic enhancement effect on the battery performance, which inspires new ideas for the preparation of new organic-inorganic composite separators.

5.
J Phys Chem Lett ; 13(10): 2348-2355, 2022 Mar 17.
Artigo em Inglês | MEDLINE | ID: mdl-35254063

RESUMO

Here, a new three-dimensional (3D) porous h-BC2N was designed via the assembly of prismane C8 and boron nitride chains as the candidates for alkali metal ion battery anodes. By systematic calculations, it is found that h-BC2N is both thermally and mechanically stable, even at a temperature as high as 1000 K. Li ions can migrate with multiple diffusion directions in h-BC2N, and the minimum diffusion barrier is only 0.10 eV lower than that of graphite. The theoretical specific capacity of the h-BC2N anode for Li is 549 mAh/g, which is higher than that reported for graphite. h-BC2N is also a promising anode for sodium (NIBs) and potassium ion batteries (KIBs) whose specific capacities are also large (549 mAh/g), and the energy barriers are 0.35 and 0.19 eV, respectively. Additionally, LIBs, NIBs, and KIBs exhibit voltage stability upon charging/discharging and good cycling stability. This theoretical exploration may open a new frontier in the search for more practical 3D porous structures as LIBs, NIBs, and KIBs anodes.

6.
Sci Total Environ ; 828: 154230, 2022 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-35271923

RESUMO

Veterinary antibiotics are widely used in many countries worldwide to treat diseases and protect the health of animals. However, the effects of sulfonamide antibiotics introduced via manure and wastewater irrigation on nitrogen (N) loss in the soil-plant system remain poorly understood. Here, we conducted a pot experiment to assess the effects of sulfamethazine (SMZ) and its degradation product (2-amino-4,6-dimethylpyrimidine, ADPD) at four concentration gradients (i.e., 0, 1, 10, 100 mg kg-1) on nitrous oxide (N2O) and ammonia (NH3) emissions, and the abundances of N-cycling functional genes and sulfonamide resistance genes. We also collated 350 observations from 62 published papers and performed a meta-analysis of antibiotic addition effects on N2O emission and soil net nitrification and denitrification. Antibiotics additions showed an inhibitory effect on N2O emissions, which accords with the trend of our meta-analysis showing a significant decrease of 32%. The decreased N2O emissions were attributed to the significant reduction in the abundances of total bacterial communities, ammonia oxidizers, and nir-type denitrifiers and to the resultant changes in soil inorganic N. N2O emissions did not differ between non-environmentally relevant concentrations for SMZ but lowered with increasing ADPD concentrations. This discrepancy can be explained by differential responses of the gene abundances of ammonia oxidizers and nirK-type denitrifiers and the development of antibiotic resistance genes in the highest concentration following antibiotic additions. Antibiotic additions increased soil NH3 volatilization but did not affect vegetable yield. Therefore, these findings provide insight into how the prevalence of antibiotics in soils could alter the N-cycling process and associated gas emissions, with implications for understanding the ecological risks of antibiotics in agriculture.


Assuntos
Nitrogênio , Solo , Agricultura , Amônia/análise , Animais , Antibacterianos/farmacologia , Fertilizantes/análise , Gases/análise , Nitrogênio/análise , Óxido Nitroso/análise , Microbiologia do Solo , Sulfametazina , Sulfanilamida
7.
J Hazard Mater ; 430: 128446, 2022 05 15.
Artigo em Inglês | MEDLINE | ID: mdl-35152105

RESUMO

Piezocatalysis driven by a gentle force possesses broad application prospects for degrading organic pollutants, sterilisation, wound healing and tissue recovery. The flexible and industrially scalable poly(vinylidene fluoride) (PVDF) film is commonly used in piezocatalysis. However, under gentle force action, PVDF composite-based piezocatalysis is poor. Herein, a flexible porous film based on poly(vinylidene fluoride)-hexafluoro propylene (PVDF-HFP) is enhanced with Fenton fillers (α-Fe2O3 nanoparticles). α-Fe2O3 nanoparticles improve the piezoelectric catalysis performance of PVDF-HFP by the ß-phase enhancement and provide Fe3+ to react with H2O2 generated by the piezoelectric film itself, leading to an additional Fenton reaction. Meanwhile, the Fe3+/Fe2+ cycle in the Fenton process accelerates under the piezoelectric field, promoting the Fenton reaction for 6.9% degradation improvement. The study on Fe2O3/PVDF-HFP porous film with the piezo-Fenton reaction under flowing water may help promote new piezocatalysis designs with high efficiency for self-powered environmental purification.


Assuntos
Peróxido de Hidrogênio , Polivinil , Polímeros de Fluorcarboneto , Porosidade , Água
8.
Nanoscale ; 14(7): 2649-2659, 2022 Feb 17.
Artigo em Inglês | MEDLINE | ID: mdl-35134104

RESUMO

Developing a novel antibiotics-free antibacterial strategy is essential for minimizing bacterial resistance. Materials that not only kill bacteria but also promote tissue healing are especially challenging to achieve. Inspired by chemical conversion processes in living organisms, we develop a piezoelectrically active antibacterial device that converts ambient O2 and H2O to ROS by piezocatalytic processes. The device is achieved by mounting nanoscopic polypyrrole/carbon nanotube catalyst multilayers onto piezoelectric-dielectric films. Under stimuli by a hand-held massage device, the sterilizing rates for S. aureus and E. coli reach 84.11% and 94.85% after 10 minutes of operation, respectively. The antibacterial substrate at the same time preserves and releases drugs and presents negligible cytotoxicity. Animal experiments demonstrate that daily treatment for 10 minutes using the device effectively accelerates the healing of infected wounds on the backs of mice, promoting hair follicle generation and collagen deposition. We believe that this report provides a novel design approach for antibacterial strategies in medical treatment.


Assuntos
Nanocompostos , Staphylococcus aureus , Animais , Antibacterianos/química , Bandagens , Escherichia coli , Camundongos , Nanocompostos/química , Polímeros/farmacologia , Pirróis
9.
J Neuroinflammation ; 19(1): 23, 2022 Jan 29.
Artigo em Inglês | MEDLINE | ID: mdl-35093099

RESUMO

BACKGROUND: Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to directly bind with 5-HT2B receptor (5-HT2BR), but the precise mechanisms, whereby fluoxetine confers the anti-depressive actions via 5-HT2BR is not fully understood. Although neuroinflammation-induced A1 astrocytes are involved in neurodegenerative diseases, the role of A1 astrocyte in the pathogenesis and treatment of major depressive disorder (MDD) remains unclear. METHODS: Mice were subjected to chronic mild stress (CMS) for 6 weeks and subsequently treated with fluoxetine for 4 weeks. The depressive-like and anxiety-like behaviors and the activation of A1 reactive astrocyte in hippocampus and cortex of mice were measured. Primary astrocytes were stimulated with A1 cocktail (tumor necrosis factor (TNF)-α, interleukin (IL)-1α and C1q), activated (LPS) microglia-conditioned medium (MCM) or IL-6 for 24 h and the expression of A1-special and A2-special markers were determined using RT-qPCR and western blot. The role of 5-HT2BR in the effects of fluoxetine on A1 reactive astrocyte was measured using 5-HT2BR inhibitor and siRNA in vitro and AAVs in vivo. The functions of downstream signaling Gq protein and ß-arrestins in the effects of fluoxetine on the activation of A1 astrocyte were determined using pharmacological inhibitor and genetic knockout, respectively. RESULTS: In this study, we found that fluoxetine inhibited the activation of A1 reactive astrocyte and reduced the abnormal behaviors in CMS mice, as well as ameliorated A1 astrocyte reactivity under three different stimulators in primary astrocytes. We also showed that astrocytic 5-HT2BR was required in the inhibitory effects of fluoxetine on A1 reactive astrocyte in MDD in vivo and in vitro. We further found that the functions of fluoxetine in the activation of A1 astrocyte were independent of either Gq protein or ß-arrestin1 in vitro. ß-arrestin2 pathway was the downstream signaling of astrocytic 5-HT2BR mediated the inhibitory effects of fluoxetine on A1 astrocyte reactivity in primary astrocytes and CMS mice, as well as the improved roles of fluoxetine in behavioral impairments of CMS mice. CONCLUSIONS: These data demonstrate that fluoxetine restricts reactive A1 astrocyte via astrocytic 5-HT2BR/ß-arrestin2 pathway in a mouse model of MDD and provide a novel therapeutic avenue for MDD.


Assuntos
Transtorno Depressivo Maior , Fluoxetina , Animais , Astrócitos/metabolismo , Transtorno Depressivo Maior/metabolismo , Fluoxetina/farmacologia , Fluoxetina/uso terapêutico , Camundongos , Serotonina/metabolismo , beta-Arrestina 2/genética , beta-Arrestina 2/metabolismo
10.
Nanoscale ; 14(5): 2004-2012, 2022 Feb 03.
Artigo em Inglês | MEDLINE | ID: mdl-35072192

RESUMO

Zinc-ion hybrid capacitors (ZIHCs) are regarded as a potential candidate for large-scale energy storage devices. However, the inadequate cathode and the inferior wettability between the electrode and electrolyte hinder the construction of high-performance ZIHCs. Herein, boron (B) and sulfur (S) co-doped spongy-like hierarchically porous carbon (B2S3C) is first proposed as a cathode material for ZIHCs. Here, B doping is favorable for improving the wettability, while S doping contributes to enhancing the electrical properties. In addition, the density functional theory (DFT) results uncover that B and S atoms contribute to reducing the energy barrier between Zn2+ and the cathode, leading to boosted chemical adsorption ability of Zn2+ on the cathode. As a result, the assembled ZIHC based on B2S3C exhibits a high specific capacity of 182.6 mA h g-1 at 0.1 A g-1, an excellent capacity retention of 96.2% after 10 000 cycles and a remarkable energy density of 292.2 W h kg-1 at a power density of 62.2 W kg-1, superior to the previously reported ZIHCs. Due to the flexibility of the assembled electrodes, the solid-state ZIHC can sustain various deformations. This work paves a feasible path for the development of cost-effective and high-performance porous carbon materials.

11.
Chemistry ; 28(15): e202104287, 2022 Mar 10.
Artigo em Inglês | MEDLINE | ID: mdl-35060212

RESUMO

The molecularly selective catalysis in enzyme is central to life. However, their functioning mechanism remains elusive. We propose here that the synergistic effects from (i) effective orbital hybridizing and energy gap decreasing via chelating on single Zr atom as the catalytic center, (ii) selective supramolecular encapsulation in the cage, and (iii) piezoelectrical field motivation are able to achieve the enzyme-mimetic molecular selective high performance catalysis. Metal-organic polyhedra (MOPs) are added into a piezoelectrical polymer matrix to achieve the composite structure where ultrasonic treatment motivates redox reactions in the MOP-guest complex. Encapsulated and chelated guest such as Rhodamine B (RhB) is effectively converted with ratios higher than 90 % after 100 min. In comparison, molecules inefficient in either cage encapsulation or chelating with the Zr center can not be converted. This study first proposes a synergistic plot for enzyme-mimetic catalyst realization and is expected to inspire new mentality in efficient catalyst designing.


Assuntos
Metais , Catálise , Metais/química , Oxirredução
12.
J Int Med Res ; 50(1): 3000605211072795, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-35000479

RESUMO

Primary malignant melanoma of the female urethra (PMMFU) is extremely rare, accounting for 0.2% of all melanomas, and fewer than 200 cases have been reported worldwide. Because of the small number of clinical cases and unclear biological characteristics, there is no uniform and standard treatment protocol. We herein describe the treatment of PMMFU using carbon ion radiotherapy. The radiotherapy was delivered at 60.8 Gy (RBE) in 16 fractions, once daily, five times per week. The patient achieved complete tumor disappearance within 1 year after carbon ion radiotherapy and remained disease-free thereafter. She developed acute grade 1 radiation dermatitis and urethritis, which resolved quickly; no other toxic effects were observed. At the time of this writing, her survival duration was 33 months. This case demonstrates that carbon ion radiotherapy may be a good option for primary genitourinary mucosal malignancies.


Assuntos
Radioterapia com Íons Pesados , Melanoma , Neoplasias Cutâneas , Intervalo Livre de Doença , Feminino , Humanos , Masculino , Melanoma/radioterapia , Uretra
13.
Invest New Drugs ; 40(1): 198-208, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-34519970

RESUMO

BACKGROUND: Peritumoral fibroblasts are key components of the tumor microenvironment. Through remodeling of the extracellular matrix (ECM) and secretion of pro-tumorigenic cytokines, peritumoral fibroblasts foster an immunosuppressive milieu conducive to tumor cell proliferation. In this study, we investigated if peritumoral fibroblasts could be therapeutically engineered to elicit an anti-cancer response by abolishing the proteolytic activities of membrane-bound metalloproteinases involved in ECM modulation. METHODS: A high affinity, glycosylphosphatidylinositol (GPI)-anchored Tissue Inhibitor of Metalloproteinase (TIMP) named "T1PrαTACE" was created for dual inhibition of MT1-MMP and TACE. T1PrαTACE was expressed in fibroblasts and its effects on cancer cell proliferation investigated in 3D co-culture models. RESULTS: T1PrαTACE abrogated the activities of MT1-MMP and TACE in host fibroblasts. As a GPI protein, T1PrαTACE could spontaneously detach from the plasma membrane of the fibroblast to co-localize with MT1-MMP and TACE on neighboring cancer cells. In a 3D co-culture model, T1PrαTACE promoted adherence between the cancer cells and surrounding fibroblasts, which led to an attenuation in tumor development. CONCLUSION: Peritumoral fibroblasts can be modulated with the TIMP for the elimination of cancer cells. As a novel anti-tumor strategy, our approach could potentially be used in combination with conventional chemo- and immunotherapies for a more effective cancer therapy.


Assuntos
Fibroblastos/efeitos dos fármacos , Neoplasias/patologia , Inibidores Teciduais de Metaloproteinases/farmacologia , Proteínas ADAM/antagonistas & inibidores , Proteína ADAM17/antagonistas & inibidores , Linhagem Celular Tumoral , Células Endoteliais da Veia Umbilical Humana , Humanos
14.
Chem Eng J ; 431: 134005, 2022 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-34899039

RESUMO

With the outbreak of COVID-19, microbial pollution has gained increasing attention as a threat to human health. Consequently, many research efforts are being devoted to the development of efficient disinfection methods. In this context, hydrogen peroxide (H2O2) stands out as a green and broad-spectrum disinfectant, which can be produced and sprayed in the air directly by cavitation in ultrasonic nebulisation. However, the yield of H2O2 obtained by ultrasonic nebulisation is too low to satisfy the requirements for disinfection by spraying and needs to be improved to achieve efficient disinfection of the air and objects. Herein, we report the introduction of a zinc layer into an ultrasonic nebuliser to improve the production of H2O2 and generate additional Zn2+ by self-corrosion, achieving good disinfecting performance. Specifically, a zinc layer was assembled on the oscillator plate of a commercial ultrasonic nebuliser, resulting in a 21-fold increase in the yield of H2O2 and the production of 4.75 µg/mL Zn2+ in the spraying droplets. When the generated water mist was used to treat a bottle polluted with Escherichia coli for 30 min, the sterilisation rate reached 93.53%. This ultrasonic nebulisation using a functional zinc layer successfully enhanced the production of H2O2 while generating Zn2+, providing a platform for the development of new methodologies of spray disinfection.

15.
J Colloid Interface Sci ; 606(Pt 1): 135-147, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34388566

RESUMO

As a pseudocapacitive electrode material, nickel-cobalt bimetallic phosphide has attracted wide attention with its advantage in capacitance and chemical activity. While, like Ni-Co oxides or sulfides, the application of nickel-cobalt bimetallic phosphide is generally hampered by its confined conductivity, low chemical stability and unsatisfactory cycle durability. Herein, this work demonstrates a NiCoP@CNT@PPy (NCP@CNT@PPy) composite that is obtained by polymerizing pyrrole monomer on the surface of NiCoP@CNT complex. According to density functional theory (DFT), it is theoretically demonstrated that the bimetallic Ni-Co phosphide (NiCoP) can exhibit more electrons near the Fermi level than single Ni or Co phosphide. Under the combined effects of carboxylic carbon nanotubes (c-CNTs) and polypyrrole (PPy), the NCP@CNT@PPy electrode exhibits excellent electrochemical performance. In addition, a flexible asymmetric supercapacitor (ASC) is prepared, which demonstrated high energy density and admirable heat-resistance and flexibility performance, showing huge potential in the application of heat-resistant storage energy systems and portable wearable devices.


Assuntos
Nanotubos de Carbono , Dispositivos Eletrônicos Vestíveis , Eletrodos , Polímeros , Pirróis
16.
Small ; 18(8): e2106420, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-34936197

RESUMO

Conversion of solar and mechanical vibration energies for catalytic water splitting into H2 has gained substantial attention recently. However, the sluggish charge separation and inefficient energy utilization in photocatalytic and piezocatalytic processes severely restrict the catalytic activity. In this paper, efficient piezo-photocatalytic H2 evolution from water splitting is realized via simultaneously converting solar and vibration energy over one-dimensional (1D) nanorod-structured Cdx Zn1-x S (x = 0, 0.2, 0.4, 0.6, 0.8, 1) solid solutions. Under combined visible light and ultrasound irradiation, Cd0.4 Zn0.6 S 1D nanorods deliver a prominently synergetic piezo-photocatalytic H2 yield rate of 4.45 mmol g-1  h-1 , far exceeding that under sole ultrasound or illumination. The consumedly promoted catalytic activity of Cd0.4 Zn0.6 S is attributed to strengthened charge separation by piezo-potential as disclosed by light-assisted scanning Kelvin probe force microscopy (SKPFM), increased strain sensitivity, and desirable optimization between piezoelectricity and visible-light response due to the formation of 1D configuration and solid solution. Metal and metal oxide depositions disclose that reduction and oxidation reactions separately occur at the tips and lateral edges of the Cd0.4 Zn0.6 S nanorods, in which the spatially separated reactive sites also contribute to super catalytic activity. This work is expected to inspire a new design strategy of coupled catalysis reactions for efficient renewable fuel production.

17.
Small Methods ; 5(7): e2100125, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34927988

RESUMO

Efficient and durable electrocatalysts are highly desirable for overall water splitting. Herein, a facile strategy is demonstrated to rationally construct CoFe Prussian blue analogues (PBA)@CoP cube-on-sheet hierarchical structure by etching reaction with intermediated CoO to form PBA nanocubes. Benefitting from the heterostructured engineering, the as-synthesized CoFe PBA@CoP presents remarkable electrocatalytic performance in 1.0 m KOH, only requiring overpotentials of 100 mV for hydrogen evolution reaction (HER) and 171 mV for oxygen evolution reaction (OER) to reach the 10 mA cm-2 current density with good stability. Extraordinarily enhanced electrocatalytic performance is ascribed to not only the rapid charge transfer of active species, but also the synergistic effect between each component to achieve tuned electronic structure and abundant electrocatalytic active sites. Especially, the assembled two-electrode cell using CoFe PBA@CoP as both cathode and anode delivers the current densities of 10 mA cm-2 at a relatively low cell voltage of 1.542 V, outperforming most of low-cost bifunctional electrocatalysts reported to date. The controllable and versatile strategy will open up an avenue to prepare hybrid films for advanced electrochemical energy storage and conversion.

18.
World J Clin Cases ; 9(33): 10374-10381, 2021 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-34904113

RESUMO

BACKGROUND: Despite being the most common intraocular malignancy among adults, choroidal melanoma is a rare cancer type, even more so when accompanied by lung cancer. We report a patient with synchronous choroid melanoma and lung cancer treated with carbon ion radiotherapy (CIRT). CASE SUMMARY: A 41-year-old woman was transferred to our center with a diagnosis of choroidal melanoma in her right eye. During the examination, we found a right lung tumor that was histologically diagnosed as lung cancer. The patient was treated with CIRT for both malignant neoplasms. The CIRT dose was 70 photon equivalent doses (GyE) in five fractions for the right eye choroidal melanoma and 72 GyE in 16 fractions for the right lung cancer. At 3 mo after CIRT, the choroidal melanoma completely disappeared, as did the right lung cancer 7 mo after; the patient was in complete remission. CONCLUSION: CIRT may be an effective treatment for double primary lung cancer and choroid melanoma.

19.
ACS Appl Mater Interfaces ; 13(47): 56620-56629, 2021 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-34786937

RESUMO

Nanoscopic heterojunction stacks are prevalent in nature as well as in artificial material systems, such as the nanoscopically blended components in soil or artificial catalytic layers on device surfaces. Despite the enormous attention placed on studying individual heterojunctions, the advantageous catalytic performance of heterojunction aggregates has not been recognized. In this study, we employ the ordered N-doped TiO2 nanosheets and Au nanoparticle heterojunction multilayers obtained by a layer-by-layer technique to investigate the functional merits stemmed from heterojunction aggregates. The study demonstrates that nanoscopic heterojunction stacks promote the internal electric field that stemmed from charge separation and boost carrier separations. The aggregate-enhanced carrier separation can be harnessed in chemical conversions. The enhancement effect is influenced by both the dimensions of the entire aggregates as well as the dimensions of the nanoscopic building units. We expect the study to promote the understanding of heterojunction catalysts and corresponding matter conversion from the individual particulate level to the nanoscopic aggregate level and facilitate better harnessing of the photovoltaic effects or catalytic power in nanoscopic heterojunction aggregates.

20.
World J Clin Cases ; 9(26): 7833-7839, 2021 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-34621834

RESUMO

BACKGROUND: Radical cystectomy is considered the first choice for the treatment of muscle-invasive bladder cancer. However, for some patients who have lost the indications for surgery, external beam radiotherapy is a non-invasive and effective treatment. CASE SUMMARY: A 76-year-old patient with bladder cancer who had serious comorbidities and could not tolerate surgery or chemotherapy came to the Wuwei Heavy Ion Center. He received carbon ion radiotherapy (CIRT) with a whole-bladder dose of 44 GyE and tumor boost of 20 GyE. When he finished CIRT, his bladder cancer-related hematuria completely disappeared, and computed tomography examination showed that the tumor had obviously decreased in size. At the 3-mo follow-up, the tumor disappeared, and there were no acute or late adverse events. CIRT was well tolerated in this patient. CONCLUSION: CIRT may allow for avoiding resection and was well tolerated with curative outcomes.

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