Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 74
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Medicine (Baltimore) ; 99(2): e18619, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31914040

RESUMO

BACKGROUND: Guillain-Barré syndrome (GBS) is the most common acute paralytic neuropathy. Many clinical trials indicate acupuncture provides a good effect as a complementary therapy of Western medicine for GBS. The objective of this systematic review protocol is to provide the evidence to evaluate the effectiveness and safety of acupuncture on the treatment of GBS. METHODS: We will search relevant randomized controlled trials investigating the effect of acupuncture for GBS in following databases from start to October 2019: PubMed, Embase, the Cochrane Library, CINAHL Complete, National Digital Science Library, China National Knowledge Infrastructure, and Wanfang Database without language restriction. For articles that meet our inclusion criteria, 2 researchers will extract the data information independently, and assess the risk of bias and trial quality by the Cochrane collaboration's tool. All data will be analyzed by RevMan V.5.3.3 statistical software. RESULTS: According to the Barthel index of Activities of Daily Living (ADL) and the Medical Research Council (MRC) muscle scale, the efficacy and safety of acupuncture for GBS will be determined in this study. CONCLUSION: This systemic review will provide high quality evidence to judging whether acupuncture provides benefits to treat GBS.Prospero registration number: CRD42019158710.


Assuntos
Terapia por Acupuntura/métodos , Síndrome de Guillain-Barré/terapia , Atividades Cotidianas , Terapia por Acupuntura/efeitos adversos , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Projetos de Pesquisa
2.
Sci Rep ; 10(1): 608, 2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-31953461

RESUMO

Multiple kinases converge on the transcription factor cAMP response element-binding protein (CREB) to enhance the expression of proteins essential for long-term synaptic plasticity and memory. The p90 ribosomal S6 kinase (RSK) is one of these kinases, although its role is poorly understood. The present study exploited the technical advantages of the Aplysia sensorimotor culture system to examine the role of RSK in long-term synaptic facilitation (LTF) and long-term enhancement of neuronal excitability (LTEE), two correlates of long-term memory (LTM). Inhibition of RSK expression or RSK activity both significantly reduced CREB1 phosphorylation, LTF, and LTEE, suggesting RSK is required for learning-related synaptic plasticity and enhancement in neuronal excitability. In addition, knock down of RSK by RNAi in Aplysia sensory neurons impairs LTF, suggesting that this may be a useful single-cell system to study aspects of defective synaptic plasticity in Coffin-Lowry Syndrome (CLS), a cognitive disorder that is caused by mutations in rsk2 and associated with deficits in learning and memory. We found that the impairments in LTF and LTEE can be rescued by a computationally designed spaced training protocol, which was previously demonstrated to augment normal LTF and LTM.

3.
Sci China Life Sci ; 63(1): 18-58, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31813094

RESUMO

Reproductive biology is a uniquely important topic since it is about germ cells, which are central for transmitting genetic information from generation to generation. In this review, we discuss recent advances in mammalian germ cell development, including preimplantation development, fetal germ cell development and postnatal development of oocytes and sperm. We also discuss the etiologies of female and male infertility and describe the emerging technologies for studying reproductive biology such as gene editing and single-cell technologies.

4.
J Am Med Inform Assoc ; 27(3): 386-395, 2020 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-31841149

RESUMO

OBJECTIVE: Development of systematic approaches for understanding and assessing data quality is becoming increasingly important as the volume and utilization of health data steadily increases. In this study, a taxonomy of data defects was developed and utilized when automatically detecting defects to assess Medicaid data quality maintained by one of the states in the United States. MATERIALS AND METHODS: There were more than 2.23 million rows and 32 million cells in the Medicaid data examined. The taxonomy was developed through document review, descriptive data analysis, and literature review. A software program was created to automatically detect defects by using a set of constraints whose development was facilitated by the taxonomy. RESULTS: Five major categories and seventeen subcategories of defects were identified. The major categories are missingness, incorrectness, syntax violation, semantic violation, and duplicity. More than 3 million defects were detected indicating substantial problems with data quality. Defect density exceeded 10% in five tables. The majority of the data defects belonged to format mismatch, invalid code, dependency-contract violation, and implausible value types. Such contextual knowledge can support prioritized quality improvement initiatives for the Medicaid data studied. CONCLUSIONS: This research took the initial steps to understand the types of data defects and detect defects in large healthcare datasets. The results generally suggest that healthcare organizations can potentially benefit from focusing on data quality improvement. For those purposes, the taxonomy developed and the approach followed in this study can be adopted.

5.
Org Lett ; 21(24): 10069-10074, 2019 Dec 20.
Artigo em Inglês | MEDLINE | ID: mdl-31814413

RESUMO

A vinylogous addition-cyclization reaction of cyclic α-amide enones with good yields and excellent regioselectivity catalyzed by cinchona squaramides has been reported. Using 4-aryl-3-butenyl N-acylpyrazoles as nucleophiles led to 1,4-selective γ-addition of enones, and 1,2-selective γ-addition of enones took place when 3-aryl-3-butenyl N-acylpyrazoles was used as the donors. The 1,4- and 1,2-selective γ-adducts are then formed into the corresponding highly stereoselective and enantioselective fused bicyclic and spirocyclic products by intramolecular cyclization. The synthetic utility of the products has also been demonstrated through further transformations of the products.

6.
Zhongguo Zhong Yao Za Zhi ; 44(20): 4387-4396, 2019 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-31872623

RESUMO

To evaluate the effectiveness and safety of Xiyanping Injection in the treatment of acute bronchitis in children. The research systematically retrieved four Chinese databases( namely CNKI,VIP,Wan Fang,Sino Med) and four English databases( namely EMbase,Cochrane Library,Medline,Clinical Trail.gov). The retrieval time ranged from the commencement of each database to April2019. According to pre-set inclusion criteria and exclusion criteria,randomized controlled trials( RCTs) of Xiyanping Injection in the treatment of acute bronchitis in children were screened out. The quality assessment of the included studies was performed using the " Cochrane Bias Risk Assessment" tool,and the Meta-quantitatively analysis on the included studies was performed using Rev Man 5.3 software. A total of 648 articles were retrieved,and 10 studies were finally included. Except for one multi-arm test,the total sample size was 1 260,including 630 cases in the test group and 630 cases in the control group. The overall quality of the included study was not high. The results of Meta-analysis showed that in terms of antipyretic time,Xiyanping Injection combined with routine therapy was superior to routine therapy in the shortening of fever time in children with acute bronchitis( MD =-0.94,95%CI[-1.18,-0.70],P<0.000 01); in the overall efficacy,Xiyanping Injection combined with routine therapy was superior to routine therapy( RR = 1. 34,95% CI[1.26,1.42],P<0.000 01) and Yanhuning Injection + routine therapy( RR = 1.28,95%CI[1.19,1.38],P<0.000 01); descriptive analysis showed that Xiyanping Injection was excellent in the overall efficacy in treating acute bronchitis in children. The differences between the two groups were statistically significant( P< 0.000 1). The adverse reactions included in the study were mild adverse reactions,with no impact on treatment. Based on the results of this study,Xiyanping Injection combined with routine therapy or other Western medicine had a certain effect on acute bronchitis in children,especially in improving the overall efficacy of acute bronchitis in children. No serious adverse reactions were observed. And in the time of fever,cough and cough disappearance time,lung voice loss time,Xiyanping Injection + routine therapy or Western medicine therapy was better than routine therapy or Western medicine therapy. However,the small size of included studies,the low quality of the included studies,and the existence of publication bias and the low quality of the evidence had impacts on the reliability of the conclusion. Therefore,more large-sample,multi-center,well-designed,rigorous randomized controlled trials with best case reports are required to further verify the efficacy and safety.


Assuntos
Bronquite/tratamento farmacológico , Medicamentos de Ervas Chinesas/uso terapêutico , Doença Aguda , Criança , Humanos , Injeções , Masculino , Reprodutibilidade dos Testes
7.
Med Sci Monit ; 25: 7735-7745, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31613871

RESUMO

This study aimed to investigate the intrinsic mechanisms of Qishen granules (QSG) in the treatment of HF, and to provide new evidence and insights for its clinical application. Information on QSG ingredients was collected from Traditional Chinese medicine systems pharmacology (TCMSP), TCM@Taiwan, TCMID, and Batman, and input into SwissTargetPrediction to identify the compound targets. HF-related targets were detected from Therapeutic Target Database (TTD), Disgenet-Gene, Drugbank database, and Online Mendelian Inheritance in Man (OMIM) database. The overlap targets of QSG and HF were identified for pathway enrichment analysis by utilizing the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. The protein-protein interaction (PPI) network of QSG-HF was constructed, following by the generation of core targets, construction of core modules, and KEGG analysis of the core functional modules. There were 1909 potential targets predicted from the 243 bioactive compounds in QSG which shared 129 common targets with HF-related targets. KEGG pathway analysis of common targets indicated that QSG could regulated 23 representative pathways. In the QSG-HF PPI network analysis, 10 key targets were identified, including EDN1, AGT, CREB1, ACE, CXCR4, ADRBK1, AGTR1, BDKRB1, ADRB2, and F2. Further cluster and enrichment analysis suggested that neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway, renin secretion, vascular smooth muscle contraction, and the renin-angiotensin system might be core pathways of QSG for HF. Our study elucidated the possible mechanisms of QSG from a systemic and holistic perspective. The key targets and pathways will provide new insights for further research on the pharmacological mechanism of QSG.


Assuntos
Medicamentos de Ervas Chinesas/metabolismo , Medicamentos de Ervas Chinesas/farmacologia , Insuficiência Cardíaca/tratamento farmacológico , China , Humanos , Medicina Tradicional Chinesa , Mapas de Interação de Proteínas , Transdução de Sinais/efeitos dos fármacos
8.
Zhongguo Zhong Yao Za Zhi ; 44(14): 2914-2925, 2019 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-31602833

RESUMO

To systematically review the efficacy and safety of Huoxiang Zhengqi Pills combined with Western medicine in the treatment of acute gastroenteritis. Four Chinese databases( CNKI,VIP,Wan Fang,Sino Med) and three English databases( Cochrane Library,Medline,EMbase) were systematically and comprehensively searched from the database establishment to April 2019 to collect the randomized controlled trials( RCTs) about the treatment of acute gastroenteritis with Huoxiang Zhengqi Pills combined with Western medicine. Two investigators independently performed literature screening,data extraction and bias risk assessment. Rev Man 5. 3 software was used for data analysis. A total of 316 articles were retrieved and finally 44 studies were included in this study,involving 4153 patients. The overall quality of the included studies was generally low. Meta-analysis results showed that in the total clinical effective rate,Huoxiang Zhengqi Pills combined with conventional treatment or norfloxacin tablets was superior to conventional treatment or norfloxacin tablets alone. In terms of the time for improving clinical symptoms,Huoxiang Zhengqi Pills combined with conventional treatment or norfloxacin tablets could better relieve fever than conventional treatment or norfloxacin tablets alone. In terms of incidence of adverse reactions,there was no statistical difference between Huoxiang Zhengqi Pills combined with conventional treatment and conventional treatment alone. Other outcome measures were affected by various factors( such as inclusion of only 1 study or excessive heterogeneity among studies) and could not be concluded. Due to the limitations of the quality and quantity of included studies,this conclusion still needs to be verified by more high quality researches.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Gastroenterite/tratamento farmacológico , Humanos , Norfloxacino/uso terapêutico , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
9.
Medicine (Baltimore) ; 98(35): e17003, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31464956

RESUMO

BACKGROUND: The proportion of application of acupuncture for chronic atrophic gastritis (CAG) is increasing over time. We will conduct this study to explore the efficacy and safety of acupuncture as a treatment method for CAG. METHODS: We will go through domestic and foreign databases until July 2019 to identify related randomized controlled trials that explored the effectiveness of acupuncture for CAG. RevMan (V.5.3) and test sequential analysis (V.0.9) will be used for mata-analysis and trial sequential analysis. RESULTS: This study will update previous evidence summaries of acupuncture and determine the efficacy and safety of acupuncture for CAG based on clinical effectiveness rate, clearance of Helicobacter pylori (H pylori) infection, and quality of life and symptom scores. CONCLUSION: This study will determine the evidence for judging whether acupuncture provides benefits in the treatment of CAG, and will support the application of acupuncture in the recovery of patients with CAG. REGISTRATION NUMBER: CRD42019127916.


Assuntos
Terapia por Acupuntura/métodos , Gastrite Atrófica/epidemiologia , Gastrite Atrófica/terapia , Infecções por Helicobacter/epidemiologia , Infecções por Helicobacter/terapia , Terapia por Acupuntura/efeitos adversos , Qualidade de Vida , Ensaios Clínicos Controlados Aleatórios como Assunto , Projetos de Pesquisa
10.
Org Lett ; 21(18): 7337-7341, 2019 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-31465234

RESUMO

Reported herein is an inverse-electron-demand oxa-Diels-Alder reaction that is remotely ß,γ-regioselective with ß,γ-unsaturated amides and ß,γ-unsaturated-α-ketoesters using a bifunctional catalyst. It can provide different kinds of dihydropyrans bearing three subsequent chiral carbon centers in good to high yield (61-99%) and with complete enantioselectivity (99 to >99% ee). Furthermore, a larger-scale experiment confirmed the reliability of the current reaction, and further effective transformation of the product has been realized.

11.
Medicine (Baltimore) ; 98(33): e16829, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31415403

RESUMO

BACKGROUDS: Moxibusion is a famous traditional Chinese medicine (TCM) treatment, which can be used to treat stable angina pectoris for many years. We will conduct this study to explore the efficacy and safety of moxibustion as an additional therapy and to provide more reliable evidence for clinical practice. METHODS: We will go through 8 databases until July 2019 to identify related randomized controlled trials that compared moxibustion with the control group. The main result is the clinical effective rate. RevMan (V.5.3) and test sequential analysis (V.0.9) will be used for mata analysis and trial sequential analysis. RESULTS: This study will provide a high-quality synthesis of current evidence of moxibustion and we have a specific opportunity to determine the efficacy and safety of moxibustion in patients with stable angina pectoris. CONCLUSIONS: This study will explore whether or not moxibustion can be used as one of the non-drug therapies to prevent or treat stable angina pectoris, especially in the elderly population with related risk factors. REGISTRATION NUMBER: CRD42018112830.


Assuntos
Angina Estável/terapia , Medicina Tradicional Chinesa/métodos , Moxibustão/métodos , Adulto , Idoso , Feminino , Humanos , Masculino , Metanálise como Assunto , Pessoa de Meia-Idade , Projetos de Pesquisa , Resultado do Tratamento
12.
Medicine (Baltimore) ; 98(23): e16033, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31169745

RESUMO

BACKGROUND: The worldwide organ shortage continues to be the main limitation of liver transplantation. To bridge the gap between the demand and supply of liver grafts, it becomes necessary to use extended criteria donor livers for transplantation. Hypothermic machine perfusion (HMP) is designed to improve the quality of preserved organs before implantation. In clinical liver transplantation, HMP is still in its infancy. METHODS: A systematic search of the PubMed, EMBASE, Springer, and Cochrane Library databases was performed to identify studies comparing the outcomes in patients with HMP versus static cold storage (SCS) of liver grafts. The parameters analyzed included the incidences of primary nonfunction (PNF), early allograft dysfunction (EAD), vascular complications, biliary complications, length of hospital stay, and 1-year graft survival. RESULTS: A total of 6 studies qualified for the review, involving 144 and 178 liver grafts with HMP or SCS preservation, respectively. The incidences of EAD and biliary complications were significantly reduced with an odds ratio (OR) of 0.36 (95% confidence interval [CI] 0.17-0.77, P = .008) and 0.47 (95% CI 0.28-0.76, P = .003), respectively, and 1-year graft survival was significantly increased with an OR of 2.19 (95% CI 1.14-4.20, P = .02) in HMP preservation compared to SCS. However, there was no difference in the incidence of PNF (OR 0.30, 95% CI 0.06-1.47, P = .14), vascular complications (OR 0.69, 95% CI 0.29-1.66, P = .41), and the length of hospital stay (mean difference -0.30, 95% CI -4.10 to 3.50, P = .88) between HMP and SCS preservation. CONCLUSIONS: HMP was associated with a reduced incidence of EAD and biliary complications, as well as an increased 1-year graft survival, but it was not associated with the incidence of PNF, vascular complications, and the length of hospital stay.


Assuntos
Hipotermia Induzida/métodos , Transplante de Fígado/métodos , Preservação de Órgãos/métodos , Perfusão/métodos , Complicações Pós-Operatórias/epidemiologia , Adulto , Aloenxertos/irrigação sanguínea , Doenças dos Ductos Biliares/epidemiologia , Doenças dos Ductos Biliares/etiologia , Doenças dos Ductos Biliares/prevenção & controle , Feminino , Sobrevivência de Enxerto , Humanos , Incidência , Fígado/irrigação sanguínea , Transplante de Fígado/efeitos adversos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Disfunção Primária do Enxerto/epidemiologia , Disfunção Primária do Enxerto/etiologia , Disfunção Primária do Enxerto/prevenção & controle , Fatores de Tempo
13.
Sci Total Environ ; 678: 21-29, 2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31075588

RESUMO

Monitoring and mapping the sensitivity of grassland ecosystems to climate change is crucial for developing sustainable local grassland management strategies. The sensitivity of alpine grasslands to climate change is considered to be high on the Qinghai-Tibet Plateau (QTP), yet little is known about its spatial pattern, and particularly the variations between different elevations. Here, based on the Normalized Difference Vegetation Index (NDVI) and three climate variables (air temperature, precipitation, and solar radiation), we modified a vegetation sensitivity index-approach to capture the relative sensitivity of alpine grassland productivity to climate variability on the QTP during 2000-2016. The results show that alpine grasslands on the southern QTP are more sensitive to climate variability overall, and that the climate factors driving alpine grassland dynamics are spatially heterogeneous. Alpine grasslands on the southern QTP are more sensitive to temperature variability, those on the northeastern QTP display strong responses to precipitation variability, and those on the central QTP are primarily influenced by a combination of radiation and temperature variability. The sensitivity of alpine grasslands to climate variability increases significantly along an elevational gradient, especially to temperature variability. This study underscores that alpine grasslands at higher elevations on the QTP are more sensitive to climate variability than those at lower elevations at the regional scale.


Assuntos
Mudança Climática , Monitoramento Ambiental , Pradaria , Altitude , Tibet
14.
Zhongguo Zhong Yao Za Zhi ; 44(7): 1503-1508, 2019 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-31090311

RESUMO

To evaluate the efficacy and safety of Lianhua Qingwen Capsules in the treatment of viral influenza in order to guide clinical medication. Randomized controlled trials(RCTs) regarding Lianhua Qingwen Capsules for treatment of viral influenza were searched in the CNKI, WanFang, VIP, SinoMed and PubMed. The quality of papers selected based on the inclusion criteria were assessed according to the Cochrane collaboration method and Meta-analysis was performed by using RevMan 5.3 software. A total of 8 articles were included, with a total sample size of 955 cases, including 478 cases in the treatment group, and 477 cases in the control group. In terms of the therapeutic effect, Lianhua Qingwen Capsules group was superior to the control group, with a total effective rate RR=1.20, 95%CI [1.09,1.32], P=0.70; recovery rate of body temperature RR=1.13, 95%CI [1.02,1.24], P=0.001; rate of symptom improvement RR=1.18, 95%CI [1.12,1.24], P=0.16. In terms of adverse reactions, the control group was superior to Lianhua Qingwen Capsules, with the incidence of adverse reactions RR=1.54, 95%CI [0.73,3.24], P=0.93. Lianhua Qingwen Capsules has a better therapeutic effect on viral influenza, but the incidence of adverse reactions is high, and its safety must be taken seriously. Given the small number of documents included and the low quality, the efficacy and safety of Lianhua Qingwen Capsules shall be confirmed by more high-quality clinical studies.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Influenza Humana/tratamento farmacológico , Cápsulas , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto
15.
Zhongguo Zhong Yao Za Zhi ; 44(8): 1668-1673, 2019 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-31090333

RESUMO

To analyze the clinical characteristics of Maixuekang Capsules combined with traditional Chinese medicines in the treatment of patients with nephrotic syndrome,and provide references for improving rationality of clinical drug use. Based on the database of hospital information system(HIS) in 15 hospitals in China,the electrical medical records of the patients diagnosed as nephrotic syndrome and treated with Maixuekang Capsules were collected. Their diagnostic information and characteristics of combined traditional Chinese medicines were analyzed by using association rules. The results showed that 1 588 patients of nephrotic syndrome who used Maixuekang Capsules were often complicated with hypertension(863 cases,accounting for 7. 54%),anemia(551 cases,accounting for 4. 81%),and coronary heart disease(349 cases,accounting for 3. 05%). Maixuekang Capsules were mainly combined with Tabellae Rhei et Natrii Bicarbonatis,Baining Capsules,tanshinone,Ganmao Qingre Granule,Shuxuening Injection in treating nephrotic syndrome. The results indicated that in the real world,Maixuekang Capsules was mainly used in combination with traditional Chinese medicines such as blood-activating and stasis-removing agents,pathogens eliminating and supporting healthy Qi agents,digestants,anti-bacterial and anti-inflammatory agents,wind-dispersing and antipyretic agents for patients with nephropathy. By the pharmacological effect,it was suitable for nephropathy patients based on combined diagnosis. The association rules of combination were specific,and can provide reference for subsequent studies and rational clinical medication of traditional Chinese medicines.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Síndrome Nefrótica/tratamento farmacológico , Anemia/complicações , Cápsulas , China , Doença das Coronárias/complicações , Humanos , Hipertensão/complicações , Medicina Tradicional Chinesa
16.
Zhongguo Zhong Yao Za Zhi ; 44(1): 186-192, 2019 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-30868831

RESUMO

To systemically evaluate the efficacy and safety of Jintiange Capsules in the treatment of postmenopausal osteoporosis(PMOP).Seven literature databases were retrieved systematically,and two reviewers independently searched and screened studies,extracted data,and included all the randomized controlled trials on Jintiange Capsules in the treatment of PMOP.Interventions included comparison of Jintiange Capsules with placebo and routine treatment,and the studies on Jintiange Capsules combined with routine treatment versus conventional treatment were also included.The evaluation indicators of the study included at least one of the followings:fracture,quality of life,daily living ability,clinical symptoms,death,adverse events/adverse reactions,bone density,and bone metabolism indexes.The original study quality evaluation was conducted by following the Cochrane Handbook standard and statistical analysis was performed by using Rev Man 5.2.A total of 7 randomized controlled trials were included and the study quality was low.Meta-analysis showed that as compared with conventional treatment alone,Jintiange Capsules combined with conventional treatment showed more obvious effects in pain relief(MD=-0.98,95% CI[-1.55,-0.41],P=0.000 8),increasing blood calcium levels(MD=0.05,95% CI[0.02,0.09],P=0.003) and lowering serum alkaline phosphatase levels(MD=-12.92,95% CI[-24.09,-1.75],P=0.02).In addition,the Chinese patent medicine alone or in combination with conventional treatment was relatively safe.In conclusion,Jintiange Capsules has a certain effect in treating PMOP,but the quality of evidence is low.It is necessary to conduct well designed randomized controlled trials and select recognized evaluation indicators,especially the end outcomes in order to further improve the clinical evidence.


Assuntos
Antineoplásicos/uso terapêutico , Densidade Óssea , Fraturas Ósseas/prevenção & controle , Osteoporose Pós-Menopausa/tratamento farmacológico , Cálcio/sangue , Cápsulas , Feminino , Humanos , Masculino , Qualidade de Vida
17.
J Environ Manage ; 235: 432-441, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30710853

RESUMO

Historical trends show that the total area of agricultural land in Nepal has changed markedly over time, but few studies have addressed the causative drivers underlying this change. Evaluating the perceptions of farmers is an effective tool for addressing this issue because it reflects the full range of drivers associated with changes in land use. This study utilizes historical agricultural area, population, and climate data for 1910-2010, combined with a series of applied household surveys and focus group discussions to assess farmers' perceptions of these changes and identify the major drivers. The paired t-test was employed to measure differences between various groups of drivers. The total area of agricultural land in Nepal has expanded rapidly since 1910, more intensively in the southern (Tarai) and central (Hill) ecological regions of the country, and has decreased slightly near large cities in recent decades. Farmers' perceptions show that socioeconomic variables were considered to be the crucial drivers of changes in agricultural land use. The three other major drivers were grouped as: neighborhood, climate-topography, and policy drivers. In particular, farmers pointed to the high level of population growth (93.96%) as the main factor underlying the changes, and the majority of drivers are associated with this variable. Access to roads (77.36%), urbanization (33.77%), government policies (23.58%), and remittance impact (16.79%) are other notable triggering variables. The paired t-test results equating variables from different groups of drivers and ecological regions indicate varied significance (p-values range from 0.004 to 0.983). Our analysis confirms that the synergy between social and natural observations can be integrated to obtain research findings that identify scientific and social issues. The interplay between the drivers should be emphasized in developing plans for sustainable agricultural land use management.


Assuntos
Agricultura , Fazendeiros , Mudança Climática , Conservação dos Recursos Naturais , Humanos , Nepal , Urbanização
18.
Clin Interv Aging ; 14: 91-104, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30655662

RESUMO

Purpose: The aim of this meta-analysis was to evaluate the efficacy of Tai chi (TC) as an adjuvant treatment for osteopenia and primary osteoporosis. Methods: We went through eight databases to identify relevant randomized controlled trials that compared TC with a control group. The primary outcome was osteoporosis-related fractures (fracture incidence). Meta-analyses and trial sequential analyses (TSA) were conducted using RevMan 5.3 and TSA 0.9. Results: Fifteen randomized controlled trials involving a total of 857 patients were included in the analyses. No trials reported primary outcome; however, bone mineral density (BMD) values differed significantly in subgroup 1 (TC vs no treatment; weighted mean difference [WMD] =0.05 g/cm2, 95% CI 0.03 to 0.07; P<0.00001; P for heterogeneity =0.22, I 2=22%) and subgroup 2 (TC vs conventional treatments; WMD =0.16 g/cm2, 95% CI 0.11 to 0.21; P<0.00001; P for heterogeneity =0.008, I 2=75%). In addition, two trials compared TC with conventional treatments, which found a significant difference in bone gla protein (standardized mean difference =-1.18, 95% CI -1.66 to -0.70; P<0.00001; P for heterogeneity =0.58, I 2=75%). The results of the BMD were confirmed by TSA. Also, TC may have a certain effect on the relief of osteoporotic pain (WMD = -2.61, 95% CI -3.51 to -1.71; WMD = -1.39, 95% CI -2.01 to -0.77). However, it did not promote the quality of life, level of serum calcium, serum phosphorus, and also had no effect on bone turnover markers. Conclusion: Although there is no study monitoring fracture incidence, TC may be beneficial for patients in improving BMD values, level of bone gla protein, and relieving osteoporotic pain. However, due to the low methodological quality, current evidence for treating osteopenia and primary osteoporosis through TC is insufficient.


Assuntos
Osteoporose/terapia , Tai Ji , Idoso , Densidade Óssea , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Qualidade de Vida
19.
Cartilage ; 10(4): 408-416, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-29562767

RESUMO

OBJECTIVE: The CC chemokine family member eotaxin-1, also named chemokine C-C motif ligand 11 (CCL11), has been detected in knee osteoarthritis (OA) and could induce breakdown of cartilage matrix. This study was performed to investigate the plasma and synovial fluid eotaxin-1 levels with the disease progression in elderly Han Chinese with primary knee OA. DESIGN: A total of 143 elderly primary knee OA patients and 135 healthy controls were enrolled in the study. The Western Ontario and McMaster Universities Arthritis Index (WOMAC) was performed to evaluate the clinical severity. The radiographic severity was assessed by Kellgren-Lawrence (K-L) grading. Plasma and synovial fluid (SF) eotaxin-1 levels were explored using enzyme-linked immunosorbent assay. The SF levels of matrix metalloproteinase-3 (MMP-3) and interleukin-6 (IL-6) were also examined. RESULTS: Elevated plasma eotaxin-1 levels were found in knee OA patients compared with healthy controls. Eotaxin-1 levels in SF of knee OA patients with K-L grade 4 were significantly elevated compared with those with K-L grades 2 and 3. Meanwhile, knee OA patients with K-L grade 3 had significantly increased SF levels of eotaxin-1 compared with those with K-L grade 2. Plasma eotaxin-1 levels in different K-L grading did not reach significant difference. Eotaxin-1 levels in SF of knee OA patients were significantly associated with disease severity evaluated by KL grading criteria. In addition, eotaxin-1 levels in SF were positively related to clinical severity illustrated by WOMAC as well as biochemical markers MMP-3 and IL-6. CONCLUSIONS: Eotaxin-1 levels in SF instead of plasma, were independently and positively related to the disease severity in elderly knee OA patients. The inhibition of eotaxin-1 and its related signaling pathways may serve as a novel therapeutic approach for OA progression.

20.
Biomed Res Int ; 2019: 1642575, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31915683

RESUMO

Qishen granules (QSG) are a famous formula with cardioprotective properties to heart failure (HF). The aim of this study was to investigate the underlying mechanism of QSG on apoptosis and fibrosis in the treatment of HF. HF model was induced by left anterior descending artery ligation on Sprague-Dawley rats. Transcriptome analysis was used to investigate the regulatory pathways of QSG on HF. Interestingly, downregulated genes of QSG were significantly enriched in Hippo pathway which plays a crucial role in regulating cell apoptosis and proliferation. We found that QSG inhibited the expressions of proapoptotic key proteins P-53 and fibrosis-related proteins TGF-ß1, SMAD3, and CTGF. Further, we conducted research on the key proteins in the Hippo pathway upstream of CTGF and P-53. The results showed that MST1, P-MST1, P-LATS1, and RASSF1A that exert proapoptotic function were downregulated after QSG intervention. Similarly, P-YAP and P-TAZ, mediating self-degradation and apoptosis, were both observably decreased after QSG administration. Taken together, QSG are shown to be likely to exert cardioprotective effects by inhibiting the progression of apoptosis and fibrosis through Hippo pathway.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA