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1.
Medicine (Baltimore) ; 99(8): e19246, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32080128

RESUMO

INTRODUCTION: Chromosome 6pter-p24 deletion syndrome (OMIM #612582) is a rare genetic disorder characterized by deletion of the distal part of 6p. Human 6p deletion syndromes result in a variety of congential malformations. PATIENT CONCERNS: The fetus was the fourth child born to healthy non-consanguineous parents with no relevant family history. DIAGNOSIS: The fetus was diagnosed with 6pter-p24 deletion syndrome through prenatal ultrasound, magnetic resonance imaging, and chromosomal microarray analysis. The fetus had brain, skeletal, and heart malformations. The fetus was cytogenetically normal. Chromosomal microarray analysis detected an interstitial 7.999Mb deletion within the 6p25.1p24.3 region of chromosome 6. INTERVENTIONS: There was no treatment for the fetus. OUTCOMES: Pregnancy was terminated. CONCLUSIONS: To the author's knowledge, the present case is one of the first to report the prenatal diagnosis of 6pter-p24 deletion syndrome in a fetus. No published reports have described the diagnosis of 6pter-p24 deletion syndrome using multiple technologies during the antenatal period; therefore, our findings may provide a reference for other clinicians. The clinical features and pathophysiology of this prenatal diagnosis are discussed.


Assuntos
Anormalidades do Olho/diagnóstico , Feto , Perda Auditiva/diagnóstico , Cardiopatias Congênitas/diagnóstico , Hipertelorismo/diagnóstico , Diagnóstico Pré-Natal/métodos , Deleção Cromossômica , Cromossomos Humanos Par 6 , Feminino , Humanos , Gravidez
2.
Artigo em Inglês | MEDLINE | ID: mdl-32069390

RESUMO

The high-throughput (HT) computational method is a useful tool to screen high-performance functional materials. In this work, using the deformation potential method under the single band model, we evaluate the carrier relaxation time and establish an electrical descriptor (χ) characterized by the carrier effective masses based on the simple rigid band approximation. The descriptor (χ) can be used to reasonably represent the maximum power factor without solving the electron Boltzmann transport equation. Additionally, the Grüneisen parameter (γ), a descriptor of the lattice anharmonicity and lattice thermal conductivity, is efficiently evaluated using the elastic properties, omitting the costly phonon calculations. Applying two descriptors (χ and γ) to binary chalcogenides, we HT compute 243 semiconductors and screen 50 promising thermoelectric materials. For these theoretically determined compounds, we successfully predict some previously experimentally and theoretically investigated promising thermoelectric materials. Additionally, 9 p-type and 14 n-type previously unreported binary chalcogenides are also predicted as promising thermoelectric materials. Our work provides not only new thermoelectric candidates with perfect crystalline structure for the future investigations but also reliable descriptors to HT screen high-performance thermoelectric materials.

3.
Accid Anal Prev ; 137: 105438, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32004863

RESUMO

Skateboarding is being an emerging travel model, especially for young travelers. The conflict between skateboarders and the other road users has raised safety concerns for traffic engineers. Safety evaluation about skateboarder-related conflicts has not been well performed due to the low skateboarder-related crashes and the limited historical crash data. Near-crashes have been considered as surrogate data for skateboard-related safety evaluation. This paper developed a procedure to extract skateboarder-associated near-crashes automatically with the roadside Light Detection and Ranging (LiDAR). A new indicator: distance-deceleration-time profile (DDTP) which combined time, space, and deceleration information was introduced for skateboarder-pedestrian near-crash identification. The DDTP was developed for the roadside LiDAR data specially. The case studies showed that the proposed method can extract skateboarder-pedestrian safety-critical events with high accuracy. The proposed method can be also used for skateboarder-vehicle and skateboarder-bicycle near-crash identification.

4.
Phys Chem Chem Phys ; 22(7): 4106-4114, 2020 Feb 19.
Artigo em Inglês | MEDLINE | ID: mdl-32031555

RESUMO

Interfaces in materials play a critical role in a wide range of functional properties. The heterophase semicoherent interface is one of the most difficult systems in density functional theory (DFT) simulations. We have studied the segregation energies of different solutes (Si, Mg and Zn) at the Al/Al2Cu (semi)coherent interfaces based on the linear combination of atomic orbitals (LCAO). Our DFT-LCAO computed segregation energies of solutes at the Al/Al2Cu coherent interface are in good agreement with the DFT-PAW calculations. However, at the Al/Al2Cu semicoherent interface, results from the LCAO calculations are significantly different to those obtained using the PAW method. The local geometry distortion in the semicoherent interface region significantly influences the solute energetics. Considering the distortion, the segregation energies of solutes well explain the trend of the experimentally measured solute concentrations, such as the higher solute Si concentration at the semicoherent interface than that at the coherent interface, and the similar Si concentration across the semicoherent interface. The lattice mismatch effect on the solute segregation energy is investigated as well. At low lattice mismatch (0.25%), the segregation energies of Si and Mg are almost compatible. Our results shed light on improving the theoretical predictions for interfaces to determine accurate functional properties.

5.
Ann Thorac Surg ; 2020 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-31987829

RESUMO

BACKGROUND: T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) is a promising checkpoint. However, its features and prognostic value remain undetermined in esophageal squamous cell carcinoma (ESCC). This study evaluated the prognostic value of TIM-3 expression and its relationship with programmed cell death 1 (PD-1) and CD8+ tumor-infiltrating lymphocytes (TILs) in patients with surgically resected ESCC. METHODS: Expression levels of TIM-3, PD-1, and CD8+ TILs in ESCC were determined by immunohistochemistry. The association between clinicopathologic features or clinical outcomes and TIM-3 expression was analyzed. RESULTS: A total of 183 patients with ESCC who had undergone esophagectomy without implementation of neoadjuvant therapy at the Second Affiliated Hospital of Soochow University in Suzhou, China from January 2009 to December 2014 were included. PD-1 positivity (P = .032) and high CD8+ TIL density (P = .035) significantly correlated with positive TIM-3 expression. TIM-3 positivity was an independent risk factor for recurrence-free survival (RFS) (P < .001) and overall survival (OS) (P < .001). Subgroup analysis revealed that the TIM-3+PD-1+CD8 low group had the worst RFS and OS, whereas the TIM-3-PD-1-CD8 high group had the best RFS and OS (RFS: log-rank test P < .001; OS: log-rank test P < .001). CONCLUSIONS: Positive TIM-3 expression was associated with PD-1 positivity and high CD8+ TIL density and was an independent risk factor for RFS and OS in ESCC. Furthermore, the combination of TIM-3 and PD-1 expression or CD8+ TIL density could further stratify patients into different groups with distinct prognosis.

6.
Clin Nephrol ; 93(3): 140-148, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31939347

RESUMO

AIM: We aimed to apply nurse-led food exchange model intervention to peritoneal dialysis (PD) patients and verify its effectiveness. BACKGROUND: Protein-energy malnutrition is a prominent problem in patients on PD, and it has been estimated that 40% of PD patients suffer from malnutrition to some extent. INTRODUCTION: The rate of malnutrition among PD patients has been relatively high in recent years. Although a lot of effort has been made to alter the situation, an effective method has yet to be implemented. MATERIALS AND METHODS: We recruited 142 patients according to the inclusion and exclusion criteria and divided them into study group (n = 71) and control group (n = 71) using a random-number table generated by SPSS22.0. The control group received routine dietary guidance and instruction while the study group received nurse-led food exchange intervention. The subjective global assessment (SGA) scale scores, nutrition parameter, and dialysis efficacy indicators between the two groups were compared at baseline and after 12 months of intervention. RESULTS: There were no significant differences between the two groups in all dimensions at the baseline measures (p > 0.05). However, after 12 months of intervention, the study group represented a higher score of SGA while the control group declined, which was significantly different (p = 0.022). The study group had an improved level of body mass index, triceps skinfold thickness, middle-arm muscle circumference, serum albumin, prealbumin, and normalized protein catabolic rate, while the control group showed decreased levels, and these results were significantly different (p = 0.001, p = 0.019, p = 0.001, p < 0.001, p = 0.043, respectively). Moreover, blood urea nitrogen declined in the study group and increased in the control group, which was significantly different (p = 0.004). CONCLUSION: Nurse-led food exchange model intervention improved nutrition condition of PD patients dramatically. Implications for nursing and/or health policy: Our study provides a basis for health policy designers to develop nutrition programs and encourage clinical nurses to participate in PD patients' diet management.

7.
Bioresour Technol ; 297: 122388, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31734064

RESUMO

After the co-combustion of tobacco stem/black bean straw/wheat straw/millet straw/corn stalk/rice straw and coal, it was found that all tested biomass in this study could inhibit arsenic release, but only rice straw promoted arsenic release. When the acid washed biomass was mixed with coal during combustion, the release of arsenic increased. When mineral metals (Na, K, Mg, Ca, Al and Fe) and Si elements were added to the coal, the mineral metals inhibited arsenic release. However, the release of arsenic was increased when the silicon content in biomass was high. The volatiles in the biomass also promoted the release of arsenic during co-combustion. The arsenic in the ash generated from co-combustion was mainly in the sulphide-bound state. Co-combustion of biomass and coal reduced the occurrence of an exchangeable state in the ash, and also significantly reduce the possibility of leaching.


Assuntos
Arsênico , Carvão Mineral , Biomassa , Cinza de Carvão , Minerais
8.
J Med Virol ; 92(1): 71-77, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31471921

RESUMO

Gastric cancer (GC) is one of the infection-related cancers. Helicobacter pylori and Epstein-Barr virus (EBV) were established risk factors for GC. Recently, there are several reports showing the inconsistent association between hepatitis B virus (HBV) infection and the development of GC. To explore the relationship between HBV infection and the development of GC, we designed a meta-analysis of previous epidemiological studies, a hospital-based case-control study, followed by an immunohistochemistry (IHC) assay of HBV-exposed GC samples. We found that HBV infection was associated with an increased risk of GC based on the meta-analysis. No significant association between HBV infection and GC was detected according to our hospital-based case-control study. Histological examination showed that the gastric epithelium positive for HBx demonstrated a higher nuclear-cytoplasmic ratio compared to those HBx-negative cells. HBx and HBcAg were expressed more in tumors than those in normal counterparts in HBV-exposed subjects, and PD-L1 was lower in GC tissues from HBV carriers than those in HBV clearances. In conclusion, HBV infection may contribute to a higher risk for GC based on the meta-analysis and to the morphological atypia of gastric epithelium by the histological assessment, and GC patients among HBV carriers showed lower expression of PD-L1 may lose the chance for immune checkpoint blockade therapy.

9.
J Hazard Mater ; 381: 120986, 2020 01 05.
Artigo em Inglês | MEDLINE | ID: mdl-31430639

RESUMO

A series of Mn-Ce/SAPO-34 catalysts were prepared to study the catalytic oxidisation of elemental mercury (Hg0). Sulphur tolerance and SO3 formation over the catalyst were studied further. Hg0 was transported by compressed air from PSA Cavkit. NO, SO2, and NH3 are standard gases, and H2O is produced by gas carrying. Mn could incorporate into the cerium oxide lattice to form capping oxygen and well-dispersed high valance manganese ions after the addition of Ce, which was conducive to NO removal and Hg0 oxidisation. 9 Mn-9Ce showed the best performance regarding Hg0 conversion, achieving more than 92% Hg0 conversion efficiency at 50-300 °C. The sulphur resistance of the Mn-based catalyst was significantly improved after the addition of cerium due to the high affinity of Ce for SO2, and the relative content of HgSO4 was exceeded 72% on the 9 Mn-9Ce catalyst with SO2; SO3 formation over the 9 Mn-9Ce decreased by 17% compared with the 9 Mn. H2O not only reduced the available active site, but also decreased the oxidation rate of SO2. The active sites were preferentially occupied by NH3 rather than Hg0 and SO2, generated NH4+ occupied cation vacancies. Therefore, both H2O and NH3 have inhibitory effects on Hg0 conversion and SO3 formation.

10.
Ann Nutr Metab ; 75(4): 213-222, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31846973

RESUMO

BACKGROUND: Sarcopenia is a syndrome in which skeletal muscle reduction is the main manifestation of age-related and/or disease-related malnutrition associated with postoperative complications and mortality. OBJECTIVES: The aim of the current study was to investigate the association between sarcopenia and postoperative complications as well as the nutrition risk of patients with gastric cancer (GC) who received gastrectomy. In addition, a comparative analysis was performed to evaluate the diagnostic accuracy of total psoas muscle area (TPA) and skeletal muscle area (SMA) in sarcopenia. METHODS: Preoperative computed tomography scans were obtained from 279 GC patients who received a gastrectomy from June 2011 to May 2016. TPA and SMA at the level of the third lumbar vertebra (L3) were used as the sarcopenia diagnostic index. Patients were diagnosed with sarcopenia via the total psoas muscle index (TPI) and skeletal muscle index (SMI) methods. TPI and SMI were normalized with the square of the patient's height (m2) by TPA and SMA. The Clavien-Dindo complications score system was used to classify the complication extent after gastrectomy. Univariate and multivariate logistic regression analyses were carried out to evaluate the risk factors for postoperative complications. RESULTS: A total of 68 and 125 patients were diagnosed with sarcopenia by TPI and SMI, respectively. Eighty-eight (31.5%) patients experienced postoperative complications. Patients with sarcopenia also had a significantly extended postoperative stay (TPI-sarcopenia, 15.0 days vs. non-sarcopenia, 11.0 days, p < 0.001; and SMI-sarcopenia, 14.0 days vs. non-sarcopenia, 11.0 days, p < 0.001) and hospital stay (TPI-sarcopenia, 22.5 days vs. non-sarcopenia, 17.0 days, p < 0.001; and SMI-sarcopenia, 21.0 days vs. non-sarcopenia, 16.5 days, p < 0.001). Multivariate logistic analysis showed that both TPI-sarcopenia (OR 7.561, p < 0.001) and SMI-sarcopenia (OR 10.085, p < 0.001) were associated with the risk of postoperative complications. Furthermore, univariate analysis showed a high correlation between nutrition risk screening 2002 (NRS2002) and sarcopenia (p < 0.001). A total of 54 (79.4%) of the 68 patients who were classified as having sarcopenia by TPI and 94 (75.3%) of the 125 patients who were classified as having sarcopenia by SMI were diagnosed with nutritional risk. CONCLUSIONS: Sarcopenia is associated with the total length of hospital stay, postoperative hospital stay, and severe complications in GC patients undergoing gastrectomy. Moreover, SMI may be a more meaningful index than TPI in reducing the rate of misdiagnosis and in predicting adverse perioperative risk. In addition, sarcopenia may cause severe malnutrition and increases perioperative adverse risk. Thus, both sarcopenia and the NRS2002 nutritional score should be assessed during preoperative nutritional screening and evaluation for GC patients.

11.
ACS Appl Mater Interfaces ; 11(48): 45133-45141, 2019 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-31702889

RESUMO

Here, we report a peak ZT of 1.85 at 873 K for sulfur and Pb codoped polycrystalline SnSe by boosting electrical transport properties while suppressing the lattice thermal conductivity. Compared with single sulfur doped samples, the carrier concentration is improved 1 order of magnitude by Pb incorporation, thereby contributing to improved electrical conductivity and power factor. Moreover, the introduction of sulfur and Pb suppresses the bipolar thermal conductivity by enlarging the band gap. The lattice thermal conductivity significantly decreased as low as 0.13 W m-1 K-1 at 873 K due to the synergic approach involving suppressing bipolar thermal conductivity, large mass fluctuation induced by sulfur incorporation, and nanoprecipitates. We demonstrate that the combination of tailoring band structure, suppressing bipolar thermal conductivity, and introducing large mass fluctuation contributes to the high thermoelectric performance in SnSe. The high performance was achieved through boosting electrical transport properties while maintaining ultralow thermal conductivity. Our findings offer a new strategy for achieving high performance thermoelectric materials.

12.
J Cancer ; 10(22): 5469-5482, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31632491

RESUMO

Background: Docetaxel resistance is a cursing problem with adverse effects on the therapeutic efficacy of prostate cancer (PCa), involving interactions among multiple molecular components. Single or limited molecules are not strong enough as prediction biomarkers of drug resistance. Network biomarkers are considered to outperform individual markers in disease characterization. Methods: In this study, key microRNAs (miRNAs) as biomarkers were identified from the PubMed citations and miRNA expression profiles. Targets of miRNAs were predicted and enriched by biological function analysis. Key target mRNAs of the biomarker miRNAs were screened from protein-protein interaction network and gene expression profiles, respectively. The results were validated by the assessment of their predictive power and system biological analysis. Results: With this approach, we identified 13 miRNAs and 31 target mRNAs with 66 interactions in the constructed network. Integrative functional enrichment analysis and literature exploration further confirmed that the network biomarkers were highly associated with the development of docetaxel resistance. Conclusions: The findings from our results demonstrated that the identified network biomarkers provide a useful tool for predicting the docetaxel resistance and may be helpful for serving as prediction biomarkers and therapeutic targets. However, it is necessary to conduct biological experiments for further investigating their roles in the development of docetaxel resistance.

13.
Medicine (Baltimore) ; 98(39): e17293, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31574850

RESUMO

Human papillomavirus (HPV) infection is the leading cause of cervical cancer and precancerous lesions. Knowledge regarding the prevalence and genotype distribution of HPV in women is important to establish strategies for cervical cancer screening and HPV vaccination. This study aimed to evaluate the characteristics of HPV infection in Taizhou, China. HPV genotype of 10,733 women who visited Taizhou People's Hospital from November 2016 to October 2018 was determined using a PCR and hybridization-based detection test. The prevalence of overall, high risk (HR), and low risk (LR) HPV infections was 34.58%, 29.92%, and 10.12%, respectively. Of HPV-positive cases, 2417 (65.13%) were infected with a single HPV genotype and 1294 (34.87%) were infected with multiple HPV genotypes. HPV-52 was the most prevalent genotype (6.21%), followed by HPV-16 (5.33%), HPV-53 (4.03%), HPV-58 (3.89%), and HPV-81 (3.75%). The highest prevalence of HPV infection was found in women aged ≥60 years (40.72%). Furthermore, the prevalence of HPV increased with the severity of cervical lesions. In conclusions, the prevalence and genotype distribution of HPV varied with age and cervical lesions. The findings might serve as a potential reference for guiding cervical cancer screening and vaccine-based HPV prevention in Taizhou.


Assuntos
Detecção Precoce de Câncer/métodos , Genótipo , Papillomaviridae/genética , Infecções por Papillomavirus/virologia , Neoplasias do Colo do Útero/virologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Feminino , Humanos , Pessoa de Meia-Idade , Infecções por Papillomavirus/complicações , Prevalência , Estudos Retrospectivos , Neoplasias do Colo do Útero/diagnóstico , Adulto Jovem
14.
Microsc Res Tech ; 82(12): 2035-2041, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31489734

RESUMO

Electron backscatter diffraction (EBSD) device can provide crystal structure, orientation, and phase content data through analysis of EBSD patterns. The reliability and precision of these data depend on the quality of the band position and zone axes data. This study introduces a new image processing method that can accurately provide the location of Kikuchi bands and poles. In this method, pattern rotation and gray gradient calculation are employed after for the initial detection of Kikuchi lines. Hough transform and Gaussian function are used for the final definition of bands position. Based on the position of Kikuchi bands, the indices of lattice planes and zone axes can be obtained precisely and easily. Angles between zone axes are calculated using locating results. The maximum error for a single-crystal silicon sample is only 8.07%, illustrating the accuracy of this new method.

15.
World J Clin Cases ; 7(15): 2081-2086, 2019 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-31423441

RESUMO

BACKGROUND: Oncogenic osteomalacia caused by phosphaturic mesenchymal tumors is very difficult to detect. We report a case of tumor-induced osteomalacia caused by a phosphaturic mesenchymal tumor of the left femur in a middle-aged woman after medical imaging and biopsy. CASE SUMMARY: A 57-year-old woman presented with progressive bone pain for five years. She was diagnosed with hypophosphatemic osteomalacia, as her laboratory data showed low serum phosphorus and low serum calcium. Her knee joint radiography revealed an osteolytic lesion of the left femur. A computed tomography scan showed mixed density shadows in the left femur. Magnetic resonance imaging of the left femur showed the presence of an oval area with a hypointense signal in T1-weighted magnetic resonance imaging (MRI) and high-low mixed signal in T2-weighted MRI. Biopsy samples revealed the presence of short spindle cells, vascularization, and characteristics of phosphaturic mesenchymal tumors. Tumor resection was performed, and the clinical presentations and laboratory abnormalities were reversed. CONCLUSION: Diagnosis of oncogenic osteomalacia is difficult due to the varieties and localization of source tumors and absence of pathognomonic biomedical signs. Our case highlights the importance of a combination of medical imaging and biopsy in the diagnosis of oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor.

16.
Fish Shellfish Immunol ; 93: 144-152, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31326584

RESUMO

Phosphoglycerate kinase (EC 2.7.2.3, PGK) catalyses the reversible transfer of a phosphate group from 1,3-diphosphoglyceric acid and ADP to produce 3-phosphoglyceric acid and ATP, which represents the initial production of ATP during glycolysis; therefore, PGK is a key enzyme in the energy metabolism. To study the role of PGK in the resistance to WSSV infection in shrimp, the full-length cDNA of the PGK gene (LvPGK) from Litopenaeus vannamei was obtained by using homology cloning and RACE amplification. The tissue distribution of LvPGK and its expression changes in the main immune tissues after WSSV stimulation were obtained by quantitative real-time PCR. Furthermore, RNA interference (RNAi) was used to study the role of LvPGK in shrimp defending against WSSV infection. The results showed that the full-length cDNA sequence of LvPGK was 1855 bp, contained a 1248 bp open reading frame (ORF) encoding 415 amino acids, and included a conserved PGK domain. LvPGK presented ubiquitous expression in most examined tissues, with the most predominant expression in the muscle and the weakest expression in the intestine. LvPGK transcripts could be induced in the hemocytes and hepatopancreas by injection with WSSV. Both the replication of WSSV and the shrimp cumulative mortality decreased significantly after LvPGK knockdown (P < 0.01). After challenging LvPGK RNAi shrimp with WSSV, the concentration of glucose in the hepatopancreas and muscle tissue did not show significant change; however, the content of pyruvate and lactate decreased significantly (P < 0.05). Moreover, significant decreases in the expression levels of crustin, ALF1, ALF2 and ALF3 were also detected. The results suggested that LvPGK might be involved in WSSV replication by increasing host aerobic and anaerobic metabolism.


Assuntos
Regulação da Expressão Gênica/imunologia , Imunidade Inata/genética , Penaeidae/genética , Penaeidae/imunologia , Fosfoglicerato Quinase/genética , Fosfoglicerato Quinase/imunologia , Sequência de Aminoácidos , Animais , Proteínas de Artrópodes/química , Proteínas de Artrópodes/genética , Proteínas de Artrópodes/imunologia , Sequência de Bases , Perfilação da Expressão Gênica , Penaeidae/enzimologia , Fosfoglicerato Quinase/química , Filogenia , Alinhamento de Sequência , Vírus da Síndrome da Mancha Branca 1/fisiologia
17.
Bioresour Technol ; 291: 121859, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31362200

RESUMO

The adsorption mechanisms of Pb(II) and Cd(II) in aqueous solution using camellia seed husk biochars pyrolyzed at different temperatures were studied. The adsorption of Pb(II) and Cd(II) on biochars are mainly controlled by ion exchange, oxygen functional groups (OFGs) complexation, Pb(II)/Cd(II)-π interactions, and precipitation with minerals. Compared to the raw biochars, both carboxyl and phenolic hydroxyl groups increased in the biochars washed with HCl. However, the previous research ignored the effect of the increased OFGs. Thus, a revised method was proposed from this study to more accurately calculate the contribution of four different mechanisms. Precipitation with minerals was the dominant mechanism for Pb(II) and Cd(II) removal, accounting for 80.61-89.03% and 53.57-75.84%, respectively, of the total adsorption as the pyrolysis temperature increased from 300 °C to 700 °C. As for oxygen functional groups complexation, the percentage of Pb(II) and Cd(II) removal were 4.76-8.55% and 11.34-29.59%, respectively.


Assuntos
Cádmio/química , Carvão Vegetal/química , Ácido Clorídrico/química , Chumbo/química , Oxigênio/química , Adsorção , Temperatura Alta , Oxirredução , Pirólise
18.
Lung Cancer ; 134: 238-244, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31319987

RESUMO

OBJECTIVE: To further investigate the relationship between the cribriform component and spread through air spaces (STAS), and to unravel the potential pathological mechanism of poor prognoses in lung adenocarcinoma (LUAD) patients with a cribriform component. METHODS: We retrospectively reviewed the clinicopathological characteristics of 208 LUADs. The cribriform component was identified by hematoxylin and eosin staining. The identification of STAS referred to our previous study. The relationship between the cribriform component and STAS was determined by using a logistic regression model. The effects of the cribriform component and STAS on prognosis were analyzed using a Cox proportional hazards regression model. RESULTS: LUAD patients with a cribriform component had significantly inferior outcomes and increased risk of both locoregional and distant recurrences when compared with those with no cribriform component (p < 0.001). Among 67 patients with a cribriform component presented, 48 (71.6%) cases had STAS. The logistic regression model identified that the cribriform component was an independent risk factor for the presence of STAS (p = 0.044). Subgroup analysis showed that Crib+ (cribriform component present)/STAS+ (spread through air spaces positive) patients had significantly inferior outcomes when compared with Crib+/STAS- (spread through air spaces negative) patients (p < 0.001). Moreover, the multivariate Cox regression analysis further confirmed that STAS was an independent risk factor for a worsening recurrence-free survival (RFS) (p = 0.001) and overall survival (OS) (p < 0.001) in LUAD patients with a cribriform component. CONCLUSIONS: Our results indicated that STAS was more frequently observed in LUAD patients with a cribriform component. Moreover, STAS could provide helpful prognostic information in patients with stage I-III LUAD with a cribriform component.

19.
Environ Sci Technol ; 53(13): 7913-7920, 2019 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-31188572

RESUMO

Coal-fired power plants represent the largest source of mercury emissions worldwide. Using fly ash, a byproduct of these plants, as a sorbent to remove mercury has proven to be difficult. Here, we found that the fresh surface of modified fly ash has good adsorption performance, and it declines obviously with time because of unsaturation characteristics on surface. On the basis of this mechanism, our study provides a method to in situ capture mercury with high surface energy modified fly ash by mechanochemical and bromide treatment. Fresh modified fly ash with active sites is injected into the flue to directly adsorb mercury. A continuous system within a full-scale 300 MWe plant showed that the mercury adsorption performance of the modified fly ash is similar to that of activated carbon, which is the industry benchmark for the treatment of mercury emission in fossil power generation units. This is a breakthrough and indicates that modified fly ash can become an efficient and convenient industrial sorbent for the removal of mercury.


Assuntos
Poluentes Atmosféricos , Mercúrio , Adsorção , Carvão Mineral , Cinza de Carvão , Centrais Elétricas
20.
Neural Netw ; 117: 124-134, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31158644

RESUMO

In this work, a new zeroing neural network (ZNN) using a versatile activation function (VAF) is presented and introduced for solving time-dependent matrix inversion. Unlike existing ZNN models, the proposed ZNN model not only converges to zero within a predefined finite time but also tolerates several noises in solving the time-dependent matrix inversion, and thus called new noise-tolerant ZNN (NNTZNN) model. In addition, the convergence and robustness of this model are mathematically analyzed in detail. Two comparative numerical simulations with different dimensions are used to test the efficiency and superiority of the NNTZNN model to the previous ZNN models using other activation functions. In addition, two practical application examples (i.e., a mobile manipulator and a real Kinova JACO2 robot manipulator) are presented to validate the applicability and physical feasibility of the NNTZNN model in a noisy environment. Both simulative and experimental results demonstrate the effectiveness and tolerant-noise ability of the NNTZNN model.


Assuntos
Simulação por Computador , Razão Sinal-Ruído
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