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1.
Phys Rev Lett ; 123(10): 100503, 2019 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-31573287

RESUMO

Quantum computing has seen tremendous progress in past years. Due to implementation complexity and cost, the future path of quantum computation is strongly believed to delegate computational tasks to powerful quantum servers on the cloud. Universal blind quantum computing (UBQC) provides the protocol for the secure delegation of arbitrary quantum computations, and it has received significant attention. However, a great challenge in UBQC is how to transmit a quantum state over a long distance securely and reliably. Here, we solve this challenge by proposing a resource-efficient remote blind qubit preparation (RBQP) protocol, with weak coherent pulses for the client to produce, using a compact and low-cost laser. We experimentally verify a key step of RBQP-quantum nondemolition measurement-in the field test over 100 km of fiber. Our experiment uses a quantum teleportation setup in the telecom wavelength and generates 1000 secure qubits with an average fidelity of (86.9±1.5)%, which exceeds the quantum no-cloning fidelity of equatorial qubit states. The results prove the feasibility of UBQC over long distances, and thus serves as a key milestone towards secure cloud quantum computing.

2.
Clin Linguist Phon ; 33(3): 279-293, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30136866

RESUMO

Dysphonia Severity Index (DSI) is an objective multi-parametric measurement of voice quality, which has been widely used in different countries. Studies indicate that DSI may be influenced by vocal pathology, age and geographical factors, whereas gender does not significantly affect DSI. The purpose of this study was to investigate the effects of gender and age on the DSI and related parameters in a Shanghainese population. The present study measured the DSI and the parameters maximum phonation time (MPT), highest fundamental frequency (HF0), lowest intensity (LI) and Jitter in 187 Shanghainese subjects, including 106 young adults aged 18-23 years (52 males and 54 females) and 81 children aged 7-9 years (44 boys and 37 girls). Two-way analysis of variance indicated that HF0 was significantly higher in female subjects than in male subjects, in both young adults and children. Gender was not significantly associated with MPT, LI, jitter or DSI. With regard to age, MPT and DSI were significantly higher in young adults than in children, and HF0 and LI were significantly lower. No significant associations between age and jitter were detected. In terms of clinic significance, the results of this study may contribute to the establishment of a normal reference range for Shanghainese DSI values, and the influence of gender and age on DSI and its separate components.

3.
Peptides ; 106: 96-101, 2018 08.
Artigo em Inglês | MEDLINE | ID: mdl-30016700

RESUMO

For clinical use, it is essential to develop potent endomorphin (EM) analogs with reduced antinociceptive tolerance. In the present study, the antinociceptive activities and tolerance development of four potent EM-1 analogs with C-terminal oligoarginine-conjugation was evaluated and compared in the radiant heat paw withdrawal test. Following intracerebroventricular (i.c.v.) administration, all analogs 1-4 produced potent and prolonged antinociceptive effects. Notably, analogs 2 and 4 with the introduction of D-Ala in position 2 exhibited relatively higher analgesic potencies than those of analogs 1 and 3 with ß-Pro substitution, consistent with their µ-opioid binding characteristic. In addition, at a dose of 50 µmol/kg, endomorphin-1 (EM-1) failed to produce any significant antinociceptive activity after peripheral administration, whereas analogs 1-4 induced potent antinociceptive effects with an increased duration of action. Herein, our results indicated the development of antinociceptive tolerance to EM-1 and morphine at the supraspinal level on day 7. By contrast, analogs 1-4 decreased the antinociceptive tolerance. Furthermore, subcutaneous (s.c.) administration of morphine at 50 µmol/kg also developed the antinociceptive tolerance, whereas the extent of tolerance developed to analogs 1-4 was largely reduced. Especially, analog 4 exhibited non-tolerance-forming antinociception after peripheral administration. The present investigation gave the evidence that C-terminal conjugation of EM-1 with oligoarginine vector will facilitate the development of novel opioid analgesics with reduced opioid tolerance.


Assuntos
Analgésicos Opioides/farmacologia , Analgésicos/farmacologia , Arginina/química , Tolerância a Medicamentos , Oligopeptídeos/farmacologia , Animais , Membro Posterior/efeitos dos fármacos , Temperatura Alta/efeitos adversos , Masculino , Camundongos , Modelos Animais , Oligopeptídeos/síntese química , Oligopeptídeos/química , Dor/prevenção & controle , Receptores Opioides mu/efeitos dos fármacos
4.
J Zhejiang Univ Sci B ; 16(6): 524-32, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-26055914

RESUMO

The energy homeostasis-associated (Enho) gene encodes a secreted protein, adropin, which regulates the expression of hepatic lipogenic genes and adipose tissue peroxisome proliferator-activated receptor γ, a major regulator of lipogenesis. In the present study, the porcine (Sus scrofa) homologue of the Enho gene, which was named pEnho, was amplified by reverse transcriptase polymerase chain reaction (RT-PCR) using oligonucleotide primers derived from in silico sequences. The gene sequence was submitted into the GenBank of NCBI, and the access number is GQ414763. The pEnho encodes a protein of 76 amino acids which shows 75% similarity to Homo sapiens adropin. The expression profile of pEnho in tissues (liver, muscle, anterior jejunum, posterior jejunum, and ileum) was determined by quantitative real-time RT-PCR. pEnho was localized on porcine chromosome 10 and no introns were found. In conclusion, pEnho was cloned and analysed with the aim of increasing knowledge about glucose and lipid metabolism in piglets and helping to promote the health and growth of piglets through adropin regulation.


Assuntos
Regulação da Expressão Gênica no Desenvolvimento/fisiologia , Suínos/metabolismo , Sequência de Aminoácidos , Animais , Sequência de Bases , Clonagem Molecular , Dados de Sequência Molecular , Especificidade de Órgãos , Suínos/genética , Distribuição Tecidual
5.
Acta Crystallogr Sect E Struct Rep Online ; 68(Pt 4): o1128, 2012 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-22589983

RESUMO

In the title compound, C(15)H(17)NO(8), the nitro group is essentially coplanar with the aromatic ring [dihedral angle = 6.4 (3) Å]. The five-membered ring has a twist conformation. In the crystal, C-H⋯O inter-actions link the mol-ecules into a helical chain propagating along [010].

6.
Acta Crystallogr Sect E Struct Rep Online ; 68(Pt 3): o558, 2012 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-22412479

RESUMO

In the title compound, C(12)H(14)N(2)O(5), the five-membered 1,3-dioxolane ring has a twisted conformation. In the crystal, N-H⋯O and C-H⋯O hydrogen bonds link the mol-ecules into a two-dimensional network lying parallel to the ab plane. There are also C-H⋯π inter-actions present in the crystal structure.

7.
J Phys Chem B ; 110(45): 22596-600, 2006 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-17092006

RESUMO

The equilibrium and dynamic adsorption data of H(2) and D(2) on different micro- and mesoporous adsorbents with orderly structure including 3A, 4A, 5A, Y, and 10X zeolites; carbon CMK-3; silica SBA-15; and so forth were collected. Critical effect of the nanodimension of adsorbents on the adsorption behavior of hydrogen and its isotopes is shown. The highest adsorption capacity was observed at pore size 0.7 nm, but equal or even larger isotope difference in the equilibrium adsorption was observed at larger pore sizes, whereas the largest isotope difference in the dynamic adsorption was observed at 0.5 nm. The adsorption rate of D(2) is larger than that of H(2) in microporous adsorbents, but the sequence could be switched over in mesoporous materials. Linear relationship was observed between the adsorption capacity for hydrogen and the specific surface area of adsorbents although the adsorbents are made of different material, which provides a convincing proof of the monolayer mechanism of hydrogen adsorption. The linear plot for microporous adsorbents has a larger slope than that for mesoporous adsorbents, which is attributed to the stronger adsorption potential in micropores.

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