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1.
Int Heart J ; 2020 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-32350204

RESUMO

Infectious endocarditis (IE) is a rare disease with high mortality rate. Recently, red cell distribution width (RDW) has drawn special attention for predicting cardiovascular disease. This study aims to explore the relationship between RDW value and postoperative death of IE patients.Clinical records of patients with definite IE from Chinese People's Liberation Army General Hospital department of cardiovascular surgery were collected and analyzed. Clinical, echocardiographic, and biochemical variables were evaluated along with RDW.Results: A total of 158 consecutive IE patients (mean age 47.0 ± 16.3 years, male 61.4%) were enrolled in this study. According to receiver operating characteristic (ROC) curve analysis, the optimal RDW cutoff value for predicting mortality was 15.45% (area under the curve 0.913, P < 0.001). A total of 28 patients (17.8%) died postoperatively; of these, 89.3% had RDW value >15.45%. Binary regression analysis showed that aging, multiple valvular involved, valvular vegetation formation, pulmonary hypertension, and high RDW are strong predictors of postoperative death. Multiple regression analysis revealed that high RDW value was independent predictors of postoperative mortality in patients with IE (ß: 3.704, 95% confidence interval (95%CI): 2.729-604.692, P < 0.05).IE has a high inhospital mortality rate, and increased RDW is an independent predictor of postoperative death in these patients.

3.
Ann Plast Surg ; 2020 Mar 19.
Artigo em Inglês | MEDLINE | ID: mdl-32205499

RESUMO

BACKGROUND: The hand and wrist are most often in contact with electrical currents and thus most vulnerable to severe electrical burns. The treatment of such severe injury via surgical intervention remains a big challenge because of the vast tissue necrosis and the segmental vascular injury. The flow-through lateral-thigh free flap has been used effectively to resurface these defects and to reconstruct segmental vascular defects. METHODS: Between January 2014 and June 2017, 11 male patients aged 19 to 53 years were admitted to the burn unit of our institution. Each presented with severe electrical burns to the wrist with long segmental vascular injury, and 2 cases suffered from electrical burn on both wrists. After radical debridement, the soft-tissue and segmental artery defects were rebuilt through the application of flow-through lateral-thigh free flap for 1 of the ulnar or radial artery injury (7/12). Ulnar artery defects were rebuilt through the application of flow-through lateral-thigh free flap, and radial artery revascularization was done using a greater saphenous vein graft for both ulnar and radial artery injuries (5/12). Vascular condition was closely monitored throughout the treatment period. RESULTS: Forearm amputation was performed in 1 case as a result of distal immediate necrosis postinjury. Successful limb salvage was achieved in the other 12 wrists. Infection beneath the flap occurred in 3 cases but resolved after debridement. Over the course of the 3- to 12-month follow-up period, the free flaps maintained good texture and sharpness, distal circulation of affected limb became well established, and the appearances of the donor sites were acceptable. CONCLUSIONS: High-voltage electrical burns of the wrist are highly destructive, and sophisticated management of damage requires concomitant vascular reconstruction and soft-tissue coverage. The flow-through anterolateral-thigh flap is an optimal solution for this problem. Emphasis must be placed on the affected blood vessel throughout the treatment period.

4.
Health Qual Life Outcomes ; 18(1): 75, 2020 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-32188480

RESUMO

BACKGROUND: Proxy respondent-someone who assists the intended respondent or responds on their behalf-are widely applied in the measurement of health-related quality of life (HRQL). However, proxies may not provide the same responses as the intended respondents, which may bias the findings. OBJECTIVES: To determine whether the use of proxies is related to socio-demographic characteristics of the intended respondent, and to assess the possible proxy response bias of Chinese version of EQ-5D-3 L in general population. METHODS: A cross-sectional study based on a provincially representative sample from 2013 National Health Service Survey (NHSS) in Shaanxi, China was performed. HRQL was measured by Chinese version of EQ-5D-3 L. Propensity score matching (PSM) was used to get matched pairs of self-reports and proxy-reports. Before and after PSM, univariate logistic and linear models including the indicator of proxy response as the only independent variable, were employed to assess the possible proxy response bias of the dimensional and overall health status of EQ-5D-3 L respectively. RESULTS: 19.9% of the responses involved a proxy. Before PSM, the proxy-report group was younger in age and reported less unhealthy lifestyle, lower prevalence of disease, and less hospitalization than the self-report group. After PSM, it showed that the proxy-report group was statistically more likely to report health problem on each dimension of EQ-5D-3 L, with odds ratios larger than one comparing with self-report group. The means of EQ-5D-3 L index and EQ VAS of proxy-report group were 0.022 and 0.834 lower than self-report group. CONCLUSIONS: Significantly negative proxy response bias was found in Chinese EQ-5D-3 L in general population, and the magnitude of the bias was larger in physical dimensions than psychological dimensions after using PSM to control confounders.

6.
Nat Commun ; 10(1): 2930, 2019 Jul 02.
Artigo em Inglês | MEDLINE | ID: mdl-31266944

RESUMO

Cesium-based perovskite nanocrystals (PNCs) possess alluring optical and electronic properties via compositional and structural versatility, tunable bandgap, high photoluminescence quantum yield and facile chemical synthesis. Despite the recent progress, origins of the photoluminescence emission in various types of PNCs remains unclear. Here, we study the photon emission from individual three-dimensional and zero-dimensional cesium lead bromide PNCs. Using photon antibunching and lifetime measurements, we demonstrate that emission statistics of both type of PNCs are akin to individual molecular fluorophores, rather than traditional semiconductor quantum dots. Aided by density functional modelling, we provide compelling evidence that green emission in zero-dimensional PNCs stems from exciton recombination at bromide vacancy centres within lead-halide octahedra, unrelated to external confinement. These findings provide key information about the nature of defect formation and the origin of emission in cesium lead halide perovskite materials, which foster their utilization in the emerging optoelectronic applications.

7.
J Acad Nutr Diet ; 119(11): 1890-1902, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31078559

RESUMO

BACKGROUND: Caregivers' feeding behavior plays a crucial role in the development of overweight and obesity in preschoolers. However, to date, there is no broadly accepted scale or questionnaire for assessing preschoolers' caregivers' feeding behavior in China. OBJECTIVE: To develop a scale that can be used to assess preschoolers' caregivers' feeding behavior in China and to conduct a preliminary evaluation of the scale's reliability, validity, and discriminative ability. DESIGN: The scale was created through a literature review and qualitative interviews with the target population. Items were reviewed by 50 caregivers of preschoolers and 10 experienced pediatricians, and 95 items were selected to form a draft scale. The draft scale underwent three rounds of investigation, and the results from these evaluations were used to select items that formed the final scale. PARTICIPANTS/SETTING: Three groups of caregivers (n=175, 400, and 912) were sampled and stratified from urban and suburban kindergartens in the cities of Jinan and Xi'an between March 2016 and October 2017 to participate in evaluations of the draft scale. From these caregiver groups, 146, 362, and 768 participants completed valid questionnaires, respectively, which were used in the scale's evaluation. PRIMARY OUTCOME MEASURES: The general demographic data of the participants and scores of each item in the scale were the primary outcome measures. STATISTICAL ANALYSES PERFORMED: Exploratory factor analysis and variability analysis were used to evaluate the draft scale, based on data from two rounds of investigation. The structure of the scale was explored through confirmatory factor analysis, and its reliability, construct validity, and discriminative ability were evaluated based on data from a third round of investigation. RESULTS: The Chinese Preschoolers' Caregivers' Feeding Behavior Scale (CPCFBS) consisted of 35 items and seven dimensions; the total cumulative variance contribution rate was 58.6%; the Cronbach's α coefficient was .91; the split-half reliability coefficient was 0.89; and the test-retest reliability coefficient was 0.85. The age and weight status of the children and the caregivers' age and education levels, as well as family incomes and child-caregiver relationships, were correlated with feeding behavior. CONCLUSIONS: The CPCFBS appeared to have good reliability and construct validity in specific Chinese populations. Future studies are needed to confirm existing findings in different Chinese populations with larger sample sizes.

8.
J Cell Physiol ; 234(11): 19895-19910, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30963578

RESUMO

Circular RNAs (circRNAs) are a new class of RNAs, and many studies have identified thousands of circRNAs in tumor cells. Fibronectin type III domain-containing protein 3B (FNDC3B) circular RNA (circFNDC3B, circBase ID: hsa_circ_0006156) circularizes with exons 5 and 6. Gibson Assembly DNA technology was used to construct a circFNDC3B expression vector without a splice site and restriction enzyme site. We showed that circFNDC3B increased migration and invasion in gastric cancer (GC). Ectopic expression of circFNDC3B reduced the level of E-cadherin protein to promote the epithelial-mesenchymal transition in GC. RNA immunoprecipitation assays and RNA pull-down assays confirmed that circFNC3B increased CD44 expression, which was associated with cell adhesion, via the formation of a ternary complex of circFNDC3B-IGF2BP3-CD44 mRNA. These results indicated that circFNDC3B was associated with the degree of malignancy to highlight the specific characteristics of cell invasion.

9.
Appetite ; 138: 146-152, 2019 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-30917942

RESUMO

The aim of this study was to explore the relationship between caregivers' feeding behaviors and children's eating behaviors among preschoolers in China. From April to July 2016, a cross-sectional survey was administered to 912 preschoolers' caregivers in China. The Chinese Preschooler's Caregiver Feeding Behavior Scale (CPCFBS) and Chinese Preschooler's Eating Behavior Questionnaire (CPEBQ) were used to assess caregivers' feeding behaviors and children's eating behaviors, respectively. Pearson correlation and canonical correlation analysis (CCA) based on principal component analysis were performed to explore the relationships between them. Two interpretable canonical variables and structures were yielded through CCA. The first canonical variable could explain 35.1% and 29.0% of the total variance of the caregivers' feeding behaviors and the children's eating behaviors variable groups, respectively, with a canonical correlation coefficient of 0.659 (rU1,V1 = 0.659, P < 0.001). The second canonical variable could explain 17.6% and 14.9% of the total variance of the caregivers' feeding behaviors and the children's eating behaviors variable groups, respectively, with a canonical correlation coefficient of 0.309 (rU2,V2 = 0.309, P < 0.001). According to the canonical structure, higher performance behaviors of the caregiver, such as encouragement of healthy eating, responsibility for feeding, supervision of eating, behavior restricted feeding, content restricted feeding and lower weight concerns, were associated with reasonable behaviors of children, including lower emotional eating, food responsiveness, unhealthy eating habits and higher initiative eating. Our results demonstrated that caregivers' feeding behaviors were the major influencing factors of children's eating behaviors, and caregivers' encouragement of healthy eating, responsibility for feeding, supervision of eating, restricted feeding and lower weight concerns were associated with reasonable children's eating behaviors, especially low children's emotional eating, low food responsiveness, infrequent unhealthy eating habits, frequent initiative eating, infrequent satiety responsiveness and food fussiness behaviors.

10.
ACS Nano ; 13(2): 2520-2525, 2019 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-30721023

RESUMO

Scintillators, which are capable of converting ionizing radiation into visible photons, are an integral part of medical, security, and commercial diagnostic technologies such as X-ray imaging, nuclear cameras, and computed tomography. Conventional scintillator fabrication typically involves high-temperature sintering, generating agglomerated powders or large bulk crystals, which pose major challenges for device integration and processability. On the other hand, colloidal quantum dot scintillators cannot be cast into compact solid films with the necessary thickness required for most X-ray applications. Here, we report the room-temperature synthesis of a colloidal scintillator comprising CsPbBr3 nanosheets of large concentration (up to 150 mg/mL). The CsPbBr3 colloid exhibits a light yield (∼21000 photons/MeV) higher than that of the commercially available Ce:LuAG single-crystal scintillator (∼18000 photons/MeV). Scintillators based on these nanosheets display both strong radioluminescence (RL) and long-term stability under X-ray illumination. Importantly, the colloidal scintillator can be readily cast into a uniform crack-free large-area film (8.5 × 8.5 cm2 in area) with the requisite thickness for high-resolution X-ray imaging applications. We showcase prototype applications of these high-quality scintillating films as X-ray imaging screens for a cellphone panel and a standard central processing unit chip. Our radiography prototype combines large-area processability with high resolution and a strong penetration ability to sheath materials, such as resin and silicon. We reveal an energy transfer process inside those stacked nanosheet solids that is responsible for their superb scintillation performance. Our findings demonstrate a large-area solution-processed scintillator of stable and efficient RL as a promising approach for low-cost radiography and X-ray imaging applications.

11.
Medicine (Baltimore) ; 98(2): e14123, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30633227

RESUMO

By comparing the intraoperative and postoperative conditions under different surgical methods, namely, keyhole endoscopy and craniotomy, we aim to provide more reasonable surgical treatment for patients with hypertensive cerebral hemorrhage.Eighty-nine patients with cerebral hemorrhage at Rizhao People's Hospital between January 2015 and December 2016 were analyzed retrospectively. Patients were assigned to the keyhole endoscopy group and the craniotomy group. The intraoperative (the duration of operation, operative blood transfusion and loss, and hematoma clearance rate) and the postoperative parameters (death rate, rebleeding rate, edema, and postoperative activity of daily living [ADL] scores) of the 2 groups were compared.Compared with the craniotomy group, the keyhole endoscopy group exhibited decreases in mean blood loss (P < .05, 180 ±â€Š13.6 mL vs 812 ±â€Š35.2 mL), blood transfusion (P < .05, 0 mL vs 480 ±â€Š13.6 mL), the average surgical duration of operation (P < .05, 113 ±â€Š14.3 minutes vs 231 ±â€Š26.1 minutes), and the severe edema rate (P < .05, 10.9% vs 72.1%) and increases in the average hematoma clearance rate (P < .05, 95.6% vs 82.3%) and postoperative ADL scores (P < .05, 85.2% vs 39.0%). Neither the death rate (P > .05, 4.3% vs 4.7%) nor rebleeding rate (P > .05, 2.2% vs 2.3%) showed any obvious changes.Keyhole endoscopy for the treatment of hypertensive intracerebral hemorrhage has the advantages of minimal trauma with good effects, and its main reason for short operation time, reduced bleeding, and high hematoma clearance rate is the "brain-hematoma" pressure gradient. Use of the intraoperative micropull technique and removal of intracerebral hematoma in the shortest time possible are critical factors contributing to the high ADL scores in the keyhole endoscopy group. However, further validation on a larger sample size is required.


Assuntos
Craniotomia , Hemorragia Intracraniana Hipertensiva/cirurgia , Neuroendoscopia/métodos , Adulto , Idoso , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento
12.
ACS Appl Mater Interfaces ; 11(5): 5223-5231, 2019 Feb 06.
Artigo em Inglês | MEDLINE | ID: mdl-30620549

RESUMO

All-inorganic lead halide perovskites are promising materials for many optoelectronic applications. However, two issues that arise during device fabrication hinder their practical use, namely, inadequate continuity of coated inorganic perovskite films across large areas and inability to integrate these films with traditional photolithography due to poor adhesion to wafers. Herein, for the first time, to address these issues, we show a room-temperature synthesis process employed to produce CsPbBr3 perovskite nanocrystals with two-dimensional (2D) nanosheet features. Due to the unique properties of these 2D nanocrystals, including the "self-assembly" characteristic, the "double solvent evaporation inducing self-patterning" strategy is used to generate high-quality patterned thin films in selected areas automatically after drop-casting, enabling fabrication of high-performance devices without using complex and expensive fabrication processing techniques. The films are free from microcracks. In a proof-of-concept experiment, photodetector arrays are used to demonstrate the superior properties of such films. We provide evidence of both high responsivity (9.04 A/W) and high stability across large areas. The photodetectors fabricated on a flexible substrate exhibit outstanding photoresponse stability. Advanced optical and structural studies reveal the possible mechanism. Our simple and cost-effective method paves the way for the next-generation nanotechnology based on high-performance, cost-effective optoelectronic devices.

13.
Brain Behav ; 9(1): e01179, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30511376

RESUMO

OBJECTIVE: Postoperative complications are common in patients who underwent decompressive craniectomy (DC) after traumatic brain injury (TBI). However, little is known about the degree of association between the postoperative complications and the long-term outcome of adult TBI patients after DC. The aim of this study was to evaluate the risk of postoperative complications that influenced the long-term outcome of DC in TBI patients. METHOD: A total of 121 patients were studied up to 6 months after DC in TBI. The collected data included demographic, clinical and radiological information, postoperative complications, and Glasgow Outcome Scale-Extended (GOSE) scores at follow-up 6 months after DC. Based on their GOSE scores, they were divided into two functional groups: favorable (GOSE = 5-8) or unfavorable outcome (GOSE = 2-4) group. The characteristics of the two groups were compared using statistical analysis. Finally, a regression model was established and a receiver operating characteristic (ROC) curve was applied to analyze its performance power. RESULTS: Of 121 admitted patients, 31 (25.62%) sustained an unfavorable outcome. A logistic regression analysis showed that the presence of Glasgow Coma Scale (GCS) scores on admission (odds ratio [OR] 0.285, p = 0.001), posttraumatic hydrocephalus (PTH) (OR 8.688, p = 0.003), craniectomy site (OR 8.068, p = 0.033), and postoperative progressive hemorrhagic injury (PHI) (OR 6.196, p = 0.026) were independent risk factors that correlated with an unfavorable outcome. Analysis using ROC curves demonstrated that these factors had different accuracies in predicting an unfavorable outcome (AUC = 0.852 for GCS scores on admission; AUC = 0.826 for PTH, AUC = 0.617 for craniectomy site; AUC = 0.616 for postoperative PHI). The performance power of the GCS scores on admission and PTH influenced the patient's outcomes to a similar degree (p = 0.623), and either predicted the outcome better than the craniectomy site or the postoperative PHI (p < 0.05, respectively). CONCLUSION: These findings suggest that the occurrence of PTH and postoperative PHI were independently associated with an unfavorable long-term outcome after DC in patients with TBI. Early prevention and treatment of PTH and postoperative PHI may be beneficial to improve the long-term outcome, especially in patients with lower admission GCS scores or bilateral DC.


Assuntos
Lesões Encefálicas Traumáticas/cirurgia , Craniectomia Descompressiva/efeitos adversos , Hidrocefalia/etiologia , Adulto , Progressão da Doença , Feminino , Escala de Coma de Glasgow , Escala de Resultado de Glasgow , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Período Pós-Operatório , Estudos Retrospectivos , Fatores de Risco , Resultado do Tratamento
14.
Clin Respir J ; 12(11): 2551-2558, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30160381

RESUMO

BACKGROUND: The incidence and risk factors of chronic thromboembolic pulmonary hypertension (CTEPH) in patients with acute pulmonary embolism (PE) have been well reported. However, in real world, patients diagnosed with PE for the first time were usually composed of acute PE, sub-acute PE, and chronic PE, and the cumulative incidence and risk factors of CTEPH in this cohort were still unknown. METHODS: A prospective, long-term, follow-up study was conducted to assess the incidence of symptomatic CTEPH in consecutive patients with PE diagnosed for the first time. Patients with unexplained persistent dyspnea during follow-up underwent transthoracic echocardiography and, if the findings indicated pulmonary hypertension, ventilation-perfusion lung scanning and right heart catheterization. CTEPH was confirmed if perfusion defects were present, mean pulmonary artery pressure (mPAP) ≥25 mmHg and pulmonary artery wedge pressure (PAWP) ≤15 mmHg. RESULTS: The cumulative incidence of CTEPH in patients with PE diagnosed for the first time was 11.2% at 3 months, 12.7% at 1 year, 13.4% at 2 years, and 14.5% at 3 years. The following factors increased the risk of CTEPH: time from symptoms to treatment of PE ≥1 month (odds ratio (OR), 14.77), intermediate (OR, 37.63) to high risk PE (OR, 39.81), segmental and sub-segmental branch location of embolism (OR, 8.30) and PE-related primary risk factors (OR, 5.01). 9.4% of CTEPH patients developed from acute PE, and 90.6% from sub-acute and chronic PE. CONCLUSIONS: In real world, CTEPH is a relatively common and serious complication in PE patients diagnosed for the first time. Early diagnosis and treatment of PE will decrease the incidence of CTEPH in these unspecified patients.


Assuntos
Hipertensão Pulmonar/diagnóstico , Embolia Pulmonar/diagnóstico , Embolia Pulmonar/epidemiologia , Adulto , Idoso , Doença Crônica , Ecocardiografia/métodos , Feminino , Seguimentos , Humanos , Hipertensão Pulmonar/epidemiologia , Incidência , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Embolia Pulmonar/classificação , Embolia Pulmonar/diagnóstico por imagem , Pressão Propulsora Pulmonar/fisiologia , Fatores de Risco , Índice de Gravidade de Doença
15.
BMC Med Educ ; 18(1): 144, 2018 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-29921253

RESUMO

BACKGROUND: Biostatistics is a key but challenging subject in medical curricula that is usually delivered via a didactic approach in China. However, whether it is the best teaching approach to improve the learner's competency, especially for medical postgraduates is yet to be proved. Therefore, a block curriculum design was initially developed to provide selective education to the postgraduates towards the professional career of their interest. A questionnaire was designed to assess the students' perceptions toward biostatistics as these affective factors might impact the learning process. Thus, the present study aimed to detect whether the new block curriculum design could promote the students' positive perceptions and further improve the course achievement. METHODS: This cohort study investigated and assessed the perceptions toward biostatistics of the first-year postgraduates undergoing traditional teaching and block teaching, respectively. Structural equation modeling was applied to explore the association between perception and course achievement in the block teaching group. RESULTS: With a response rate of 97.84 and 96.67% from the two cohorts respectively, 499 block teaching postgraduates had more positive perceptions as compared to 465 traditionally teaching postgraduates with Likert 5-point agreement response mean of 3.50 vs. 3.31 for course value, 3.66 vs. 2.97 for course comment, and 4.29 vs. 4.10 for expectation. Moreover, block teaching students presented superior confidence about academic statistical knowledge, and therefore, 77.96% of them approved of the new teaching approach. Age, specialty, research experience, logical thinking capacity, mathematical basics, and computer basics might influence the postgraduates' self-assessment ability (all P < 0.05). Structural equation modeling confirmed a positive correlation between perceptions and the course achievements with a reasonable fit. CONCLUSIONS: The block curriculum design in the biostatistics course improved the postgraduates' positive perception and may have had a positive role in improving postgraduates' achievement in learning biostatistics.


Assuntos
Atitude do Pessoal de Saúde , Bioestatística , Currículo , Educação Médica Continuada , Ensino/estatística & dados numéricos , Adulto , China , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Percepção , Estudantes de Medicina , Inquéritos e Questionários , Adulto Jovem
16.
J Craniofac Surg ; 29(3): e287-e290, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29419591

RESUMO

OBJECTIVE: The aim of the study was to explore the values and disadvantages of micromirror in the intracranial aneurysm clipping surgery. METHODS: Micromirror was used to assist microsurgical clipping to 36 intracranial aneurysms in 31 patients, of which 3 were carotid-ophthalmic artery aneurysms, 3 were anterior choroidal artery aneurysms, 11 were posterior communicating artery aneurysms, 7 were middle cerebral artery aneurysms, 10 were anterior communicating artery or anterior cerebral artery aneurysms, and the rest were a posterior cerebral artery aneurysm and a posterior inferior cerebellar artery aneurysm. The micromirror was used before and after clipping to observe the anatomic features of necks hidden behind and medial to aneurysms, to visualize surrounding neurovascular structures, and to verify the optimal clipping position. Intraoperative indocyanine green fluorescein angiography, postoperative computerized tomography angiography, and digital subtraction angiography confirmed the success of sufficient clipping. RESULTS: Intraoperative indocyanine green angiography, postoperative computerized tomography angiography , or digital subtraction angiography were performed and showed no case of wrong or insufficient clipping of aneurysm. CONCLUSIONS: Micromirror-assisted microsurgical clipping to the intracranial aneurysm is safe, sufficient, convenient, and practical.


Assuntos
Angiografia Cerebral , Aneurisma Intracraniano , Procedimentos Neurocirúrgicos , Cirurgia Assistida por Computador , Procedimentos Cirúrgicos Vasculares , Humanos , Aneurisma Intracraniano/diagnóstico por imagem , Aneurisma Intracraniano/cirurgia
17.
J Phys Chem Lett ; 8(14): 3173-3177, 2017 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-28644033

RESUMO

With record efficiencies achieved in lead halide perovskite-based photovoltaics, urgency has shifted toward finding alternative materials that are stable and less toxic. Bismuth-based perovskite materials are currently one of the most promising candidates among those alternatives. However, the band structures of these materials, including the nature of the bandgaps, remain elusive due to extremely low photoluminescence quantum yield (PLQY) and scattering issues in their thin-film form. Here, we reveal the specific nature of the material's electronic transitions by realizing monodisperse colloidal nanocrystals (NCs) of hexagonal-phase Cs3Bi2X9 perovskites, which afford well-resolved PL features. Interestingly, the PL profile exhibits a dual-spectral feature at room temperature with comparable intensities, based on which we propose an exciton recombination process involving both indirect and direct transitions simultaneously-an observation further supported by temperature-dependent and density functional theory (DFT) calculations. Our findings provide experimental and theoretical insights into the nature of the bandgaps in bismuth halide materials-essential information for assessing their viability in solar cells and optoelectronics.

18.
J Phys Chem Lett ; 8(5): 961-965, 2017 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-28181438

RESUMO

Perovskite nanocrystals (NCs) have become leading candidates for solution-processed optoelectronics applications. While substantial work has been published on 3-D perovskite phases, the NC form of the zero-dimensional (0-D) phase of this promising class of materials remains elusive. Here we report the synthesis of a new class of colloidal semiconductor NCs based on Cs4PbBr6, the 0-D perovskite, enabled through the design of a novel low-temperature reverse microemulsion method with 85% reaction yield. These 0-D perovskite NCs exhibit high photoluminescence quantum yield (PLQY) in the colloidal form (PLQY: 65%), and, more importantly, in the form of thin film (PLQY: 54%). Notably, the latter is among the highest values reported so far for perovskite NCs in the solid form. Our work brings the 0-D phase of perovskite into the realm of colloidal NCs with appealingly high PLQY in the film form, which paves the way for their practical application in real devices.

19.
Respir Care ; 62(4): 489-496, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28119496

RESUMO

BACKGROUND: Monotherapy and sequential combination therapy have been widely used in the treatment of pulmonary arterial hypertension (PAH). There is limited evidence for initial combination therapy in patients with PAH, particularly those with World Health Organization (WHO) functional class III or IV. METHODS: Twenty-seven consecutive treatment-naive PAH subjects with WHO functional class III or IV PAH were randomized into 3 groups with a 1:1:1 ratio: a combination therapy group with 125 mg of bosentan twice daily plus 10 µg of iloprost 4-6 times/d; a bosentan monotherapy group with 125 mg of bosentan twice daily; and a iloprost monotherapy group with 10 µg of iloprost 4-6 times/d. Clinical and hemodynamic data were collected at baseline, 6 weeks, and 3 months. The primary end point was the change in the 6-min walk distance (6MWD) from baseline values. RESULTS: At baseline, there were no differences in demographics, WHO classification, hemodynamics, classification of PAH, or 6MWD among the 3 groups. The 6MWD significantly improved in the combination therapy group compared with the bosentan monotherapy and iloprost monotherapy groups at week 6 (P = .001) and after 3 months (P < .001), respectively. Secondary end points significantly improved in the combination therapy group for mean pulmonary artery pressure, cardiac index, and WHO functional classification after 3 months of treatment and for N-terminal pro-brain natriuretic peptide, Minnesota Living with Heart Failure questionnaire scores, and PaO2 after 6 weeks and 3 months of treatment, compared with the monotherapy groups. CONCLUSIONS: Initial combination therapy in treatment-naive PAH subjects with WHO functional class III or IV can significantly improve 6MWD, hemodynamics, and quality of life compared with monotherapy. Further studies with large samples and placebo controls are required to assess the tolerability and efficacy of initial combination therapy in patients with PAH. (ClinicalTrials.gov registration NCT01712997).


Assuntos
Anti-Hipertensivos/administração & dosagem , Hipertensão Pulmonar/tratamento farmacológico , Iloprosta/administração & dosagem , Sulfonamidas/administração & dosagem , Vasodilatadores/administração & dosagem , Adulto , Bosentana , Quimioterapia Combinada , Feminino , Hemodinâmica/efeitos dos fármacos , Humanos , Hipertensão Pulmonar/fisiopatologia , Masculino , Artéria Pulmonar/fisiopatologia , Qualidade de Vida , Fatores de Tempo , Resultado do Tratamento , Teste de Caminhada
20.
Turk Neurosurg ; 27(4): 500-508, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-27593801

RESUMO

AIM: To identify whether neuronavigation-assisted aspiration (NA) combined with electro-acupuncture (EA) provides better motor recovery in events of hypertensive putaminal hematoma (HPH) sized 30 to 50 ml. This study aims to examine whether neuronavigation-assisted aspiration and electro-acupuncture have additional value to cerebral hemorrhage motor rehabilitation. MATERIAL AND METHODS: 240 patients with HPH sized 30 to 50 ml and admitted within 6 to 10 hours after stroke ictus were included in this study. Group 1 contained 60 patients who underwent neuronavigation-assisted aspiration and electro-acupuncture (NAEA), group 2 contained 60 patients who underwent neuronavigation-assisted aspiration (NA), group 3 contained 60 patients who underwent electro-acupuncture (EA), and group 4 contained 60 patients who received conservative therapy consisting solely of medications. All the patients received the same therapeutic plan on admission and functional exercises three days after stroke onset. Electro-acupuncture was performed on the third day of admission; motor recovery was examined on weeks zero and eight by blinded assessors. Outcome measures included Fugl-Meyer assessment, modified Ashworth Scale and Functional Independence Measure. RESULTS: Group one showed significantly improved motor outcomes compared to group four (p < 0.01). Group one also showed significant motor improvement when pre-and post- therapy functioning was examined (p < 0.01). Cerebral edema and ischemia were significantly decreased in group one compared to group 3 and 4 (p < 0.05). While not as effective as group one treatment, group two and group three patients had significant motor recovery after intervention when compared to group four (p < 0.05). Muscular tension secondary to stroke was considerably improved between group one and group four, group two and group four, group three and group four respectively (p < 0.05). Activities of daily living (ADL) improved a lot with EA together with NA. CONCLUSION: Neuronavigation-assisted aspiration and electro-acupuncture of HPH at the early stage can provide improved motor recovery with fewer complications. Significant motor recovery can be achieved by neuronavigation-assisted aspiration with acupuncture. Based on our findings, we recommend early intervention with NA and EA in order to promote early rehabilitation of hemiplegia secondary to HPH.


Assuntos
Eletroacupuntura/métodos , Hemiplegia/terapia , Neuronavegação , Paracentese/métodos , Hemorragia Putaminal/terapia , Atividades Cotidianas , Edema Encefálico/complicações , Edema Encefálico/terapia , Terapia por Exercício , Feminino , Hemiplegia/complicações , Hemiplegia/reabilitação , Humanos , Isquemia/complicações , Isquemia/terapia , Masculino , Pessoa de Meia-Idade , Hemorragia Putaminal/complicações , Hemorragia Putaminal/tratamento farmacológico , Hemorragia Putaminal/reabilitação , Acidente Vascular Cerebral/complicações , Acidente Vascular Cerebral/terapia , Resultado do Tratamento
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