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1.
Artigo em Inglês | MEDLINE | ID: mdl-36346193

RESUMO

Excitation-dependent emission (Ex-de) materials have been of considerable academic interest and have potential applications in real life. Such multicolour luminescence is a characteristic exception to the ubiquitously accepted Kasha's rule. This phenomenon has been increasingly presented in some studies on different luminescence systems; however, a systematic overview of the mechanisms underlying this phenomenon is currently absent. Herein, we resolve this issue by classifying multicolour luminescence from single chromophores and dual/ternary chromophores, as well as multiple emitting species. The underlying processes are described based on electronic and/or geometrical conditions under which the phenomenon occurs. Before we present it in categories, related photophysical and photochemical foundations are introduced. This systematic overview will provide a clear approach to designing multicolour luminescence materials for special applications.

2.
Front Surg ; 9: 964985, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36211264

RESUMO

Background: The optimization of surgical procedures and the management of surgical quality and safety have become the focus of attention of hospital managers. The application of multimodal identification technology in the innovative management mode of hospital operating department has made remarkable progress. Methods: To investigate the effect of the upgraded multimodal identification technology on the innovative management of the operating department, 2,280 cases of laparoscopic surgery using traditional surgical management procedures from January to December 2019 before the management upgrade were set as the control group, and 2,350 laparoscopic surgeries with the upgraded multimodal identification management process from January to December 2020 were selected as the experimental group. The operating efficiency, material management efficiency, and patient experience and satisfaction of the two groups were investigated and compared. Results: Compared with traditional procedures, the upgraded multimodal surgical management system significantly improves the efficiency of laparoscopic surgery and reduces surgical consumption and costs. In addition, the multimodal surgical information identification system significantly improves the surgical experience for patients undergoing laparoscopic surgery. Conclusion: Application of multimodal identification technology improves the innovative management of operation department compared with traditional surgery management procedure.

3.
Chem Sci ; 13(29): 8679-8685, 2022 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-35974752

RESUMO

Designing delocalized excitons with low binding energy (E b) in organic semiconductors is urgently required for efficient photochemistry because the excitons in most organic materials are localized with a high E b of >300 meV. In this work, we report the achievement of a low E b of ∼50 meV by constructing phenothiazine-based covalent organic frameworks (COFs) with inherent crystallinity, porosity, chemical robustness, and feasibility of bandgap engineering. The low E b facilitates effective exciton dissociation and thus promotes photocatalysis by using these COFs. As a demonstration, we subject these COFs to photocatalytic polymerization to synthesize polymers with remarkably high molecular weight without any requirement of the metal catalyst. Our results can facilitate the rational design of porous materials with low E b for efficient photocatalysis.

4.
Angew Chem Int Ed Engl ; 61(37): e202207426, 2022 Sep 12.
Artigo em Inglês | MEDLINE | ID: mdl-35860924

RESUMO

Achieving blueshifted and enhanced emission from purely organic luminophors remains a major challenge. Herein, we report a tetracoordinate boron complex with polymorphism (Y-phase and O-phase)-dependent luminescence. Impressively, the Y-phase crystals exhibited rare piezochromic luminescent properties such as pressure-induced blue-shifted and enhanced emission. The results of theoretical and experimental tests demonstrated that this phenomenon results from the cooperative effect between the restriction of intramolecular motions and alterable charge transfer (CT) behavior during compression. This work provides an ideal model to investigate the optoelectronic properties of boron complexes. Importantly, manipulating the CT behavior through the electrophilicity of boron atoms may become a new principle for the design of piezochromic materials with blueshifted and enhanced emission.

5.
Molecules ; 27(13)2022 Jun 29.
Artigo em Inglês | MEDLINE | ID: mdl-35807420

RESUMO

With the ever-growing concern about environmental conservation, green production and water-based nanofibers have attracted more and more interest from both academic and industrial fields; nevertheless, the stabilization process of water-based nanofibers is primarily relying on the application of organic solvent-based crosslinking agents. In this work, we develop a green approach to fabricate water-resistant polyvinyl alcohol (PVA) nanofibers by using a water-based epoxy compound, N1, N6-bis(oxiran-2-ylmethyl) hexane-1,6-diamine (EH), as the crosslinker. This EH/sodium carbonate/sodium bicarbonate (CBS) solution system can break down large aggregates of PVA molecules into small ones and promote the uniform distribution of EH in the solution, resulting in the improved stability of crosslinked PVA nanofibers. We firstly report that the uniform dispersion of crosslinking agents in the electrospinning solution plays a vital role in improving the stability of spinning solutions and the water resistance of crosslinked PVA nanofibers by comparing crosslinking performances between water-based epoxy and conventional water-based blocked isocyanate (BI). This work could open up a novel strategy and green approach for the stabilization of water-based nanofibers.


Assuntos
Nanofibras , Álcool de Polivinil , Resinas Epóxi , Água
6.
Rev Assoc Med Bras (1992) ; 68(4): 445-449, 2022 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-35649065

RESUMO

OBJECTIVE: This study aimed to explore the correlation between different body components and bone mineral density in healthy adults. METHODS: A total of 306 non-manual subjects, 161 males and 145 females, were selected from the physical examination center of our hospital from June to September 2019. They were divided into control group, overweight group, and obese group according to body mass index. The muscle mass and fat mass, body fat content, trunk fat mass, upper limb and thigh fat mass, bone density of femoral neck and lumbar vertebra, and bone mineral salt content of the whole body were measured by dual-energy X-ray absorptiometry. RESULTS: Body mass index, systolic blood pressure, diastolic blood pressure, femoral neck bone mineral density, bone mineral salt content, fat mass, muscle mass, upper limb fat mass, thigh fat mass, and trunk fat mass in the overweight group and obese group were all higher than those in the control group (P<0.05). The fat mass, muscle mass, upper limb fat mass, and trunk fat mass were positively correlated with the femoral neck bone mineral density, total lumbar vertebra bone mineral density, and bone mineral salt content (P<0.05). In addition, thigh fat mass was positively correlated with femoral neck bone mineral density and total lumbar spine bone mineral density, whereas body fat content was negatively correlated with bone mineral salt content. CONCLUSION: Body composition was related to bone mineral density and bone mineral salt content, and the correlation between different body composition indexes, and bone mineral density, and bone mineral salt content was different.


Assuntos
Densidade Óssea , Sobrepeso , Adulto , Composição Corporal/fisiologia , Densidade Óssea/fisiologia , Feminino , Humanos , Masculino , Minerais , Obesidade
8.
Biomed Pharmacother ; 150: 112973, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35468581

RESUMO

Dioscin (Dio), steroid saponin, exists in several medicinal herbs with potent anticancer efficacy. This study aimed to explore the effect of Dio on the immune-related modulation and synergistic therapeutic effects of the herpes simplex virus thymidine kinase/ganciclovir (HSV-Tk/GCV) suicide gene therapy system in murine melanoma, thereby providing a research basis to improve the potential immunomodulatory mechanism underlying combination therapy. Using both in vitro and in vivo experiments, we confirmed the immunocidal effect of Dio-potentiated suicide gene therapy on melanoma. The results showed that Dio upregulated connexin 43 (Cx43) expression and improved gap junction intercellular communication (GJIC) in B16 cells while increasing the cross-presentation of antigens by dendritic cells (DCs), eventually promoting the activation and antitumor immune killing effects of CD8+ T lymphocytes. In contrast, inhibition or blockade of the GJIC function (overexpression of mutant Cx43 tumor cells/Gap26) partially reversed the potentiating effect. The significant synergistic effect of Dio on HSV-Tk/GCV suicide gene therapy was further investigated in a B16 xenograft mouse model. The increased number and activation ratio of CD8+ T lymphocytes and the levels of Gzms-B, IFN-γ, and TNF-α in mice reconfirmed the potential modulatory effects of Dio on the immune system. Taken together, Dio targets Cx43 to enhance GJIC function, improve the antigens cross-presentation of DCs, and activate the antitumor immune effect of CD8+ T lymphocytes, thereby providing insights into the potential immunomodulatory mechanism underlying combination therapy.


Assuntos
Conexina 43 , Melanoma , Animais , Comunicação Celular , Conexina 43/genética , Conexina 43/metabolismo , Apresentação Cruzada , Diosgenina/análogos & derivados , Ganciclovir/farmacologia , Ganciclovir/uso terapêutico , Junções Comunicantes/metabolismo , Terapia Genética/métodos , Humanos , Melanoma/tratamento farmacológico , Melanoma/terapia , Camundongos , Simplexvirus/genética , Simplexvirus/metabolismo , Timidina Quinase/genética , Timidina Quinase/metabolismo , Timidina Quinase/farmacologia
9.
Rev. Assoc. Med. Bras. (1992) ; 68(4): 445-449, Apr. 2022. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1376161

RESUMO

SUMMARY OBJECTIVE: This study aimed to explore the correlation between different body components and bone mineral density in healthy adults. METHODS: A total of 306 non-manual subjects, 161 males and 145 females, were selected from the physical examination center of our hospital from June to September 2019. They were divided into control group, overweight group, and obese group according to body mass index. The muscle mass and fat mass, body fat content, trunk fat mass, upper limb and thigh fat mass, bone density of femoral neck and lumbar vertebra, and bone mineral salt content of the whole body were measured by dual-energy X-ray absorptiometry. RESULTS: Body mass index, systolic blood pressure, diastolic blood pressure, femoral neck bone mineral density, bone mineral salt content, fat mass, muscle mass, upper limb fat mass, thigh fat mass, and trunk fat mass in the overweight group and obese group were all higher than those in the control group (P<0.05). The fat mass, muscle mass, upper limb fat mass, and trunk fat mass were positively correlated with the femoral neck bone mineral density, total lumbar vertebra bone mineral density, and bone mineral salt content (P<0.05). In addition, thigh fat mass was positively correlated with femoral neck bone mineral density and total lumbar spine bone mineral density, whereas body fat content was negatively correlated with bone mineral salt content. CONCLUSION: Body composition was related to bone mineral density and bone mineral salt content, and the correlation between different body composition indexes, and bone mineral density, and bone mineral salt content was different.

10.
Clin Exp Med ; 2022 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-35428957

RESUMO

Gastric cancer is a very common gastrointestinal malignancy. Since the disease is often asymptomatic in its early stage, it is often diagnosed in its late stage. In this study, our objective was to evaluate the efficacy and safety of combination chemotherapy regimens containing taxanes in the first-line treatment of advanced gastric cancer (AGC). We searched published randomized controlled trials (RCTs) to compare the effect of taxanes combined with basic chemotherapy and chemotherapy without taxanes on AGC. The extracted data are the number of people who achieved the objective response rate (ORR) and disease control rate (DCR), as well as the hazard ratio (HR) of progression-free survival (PFS) and overall survival (OS) including their 95% confidence intervals (95% CI). Six RCTs involving 2263 patients were included. Compared with chemotherapy without taxanes, patients receiving taxanes combined with basic chemotherapy had significantly longer PFS (HR 0.73, 95% CI 0.61-0.88, p = 0.001) and significantly longer OS (HR 0.80, 95% CI 0.69-0.93, p = 0.003); significantly better ORR (RR 1.34, 95% CI 1.15-1.57, p = 0.0001) and significantly better DCR (RR 1.20, 95% CI 1.08-1.33, p = 0.001). However, in patients treated with taxanes combined with basic chemotherapy, diarrhea, leukopenia and neutropenia were significantly increased (p < 0.05). In summary, taxanes combined with basic chemotherapy are superior to chemotherapy without taxanes in first-line treatment of AGC patients.

11.
Adv Mater ; 34(18): e2200380, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35243701

RESUMO

Photosynaptic organic field-effect transistors (OFETs) represent a viable pathway to develop bionic optoelectronics. However, the high operating voltage and current of traditional photosynaptic OFETs lead to huge energy consumption greater than that of the real biological synapses, hindering their further development in new-generation visual prosthetics and artificial perception systems. Here, a fully solution-printed photosynaptic OFET (FSP-OFET) with substantial energy consumption reduction is reported, where a source Schottky barrier is introduced to regulate charge-carrier injection, and which operates with a fundamentally different mechanism from traditional devices. The FSP-OFET not only significantly lowers the working voltage and current but also provides extraordinary neuromorphic light-perception capabilities. Consequently, the FSP-OFET successfully emulates visual nervous responses to external light stimuli with ultralow energy consumption of 0.07-34 fJ per spike in short-term plasticity and 0.41-19.87 fJ per spike in long-term plasticity, both approaching the energy efficiency of biological synapses (1-100 fJ). Moreover, an artificial optic-neural network made from an 8 × 8 FSP-OFET array on a flexible substrate shows excellent image recognition and reinforcement abilities at a low energy cost. The designed FSP-OFET offers an opportunity to realize photonic neuromorphic functionality with extremely low energy consumption dissipation.


Assuntos
Redes Neurais de Computação , Transistores Eletrônicos , Sinapses/fisiologia
12.
Sci Total Environ ; 820: 153190, 2022 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-35051471

RESUMO

Nanoplastics have attracted wide attention worldwide as a new potentially threatening pollutant, and they can cause harm to the organisms and pose threat to the water environment. Therefore, efficient removal techniques for nanoplastics are urgently needed. In this study, CuNi carbon material (CuNi@C) was prepared by hydrothermal method for the removal of polystyrene (PS) nanoplastics from water. CuNi@C was effectively adsorbed on PS nanoplastics. When the CuNi@C dosage increased from 0.1 g/L to 0.3 g/L, the removal efficiency of PS nanoplastics (10 mg/L) elevated from 32.72% to 99.18%. The images of the scanning electron microscope (SEM) and the Fourier transform infrared spectroscopy (FTIR) spectra of CuNi@C confirmed the adsorption of PS nanoplastics on the CuNi@C. The fitting results of adsorption kinetic models and isotherms equations demonstrated that physical adsorption and monolayer coverage were the predominant mechanisms of the PS nanoplastics adsorption on CuNi@C. Thermodynamics analysis illustrated the adsorption of PS nanoplastics on CuNi@C was a spontaneous and endothermic process. The electrostatic attraction occurred in adsorption progress, and the removal efficiency of PS nanoplastics in the acidic system was generally higher than that in the alkaline system. CuNi@C can be recycled via washing and drying treatment and these CuNi@C comparable PS nanoplastics removal performance to the original ones. After four times cycles, CuNi@C can still remove ~75% of total PS nanoplastics from water. This study reveals that CuNi@C can be used as promising techniques for the removal of PS nanoplastics from the aqueous environment.


Assuntos
Poliestirenos , Poluentes Químicos da Água , Adsorção , Carbono , Concentração de Íons de Hidrogênio , Cinética , Microplásticos , Espectroscopia de Infravermelho com Transformada de Fourier , Termodinâmica , Água , Poluentes Químicos da Água/análise
13.
Angew Chem Int Ed Engl ; 61(16): e202115551, 2022 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-34989081

RESUMO

Organic materials with excitation wavelength-dependent (Ex-de) emission are highly attractive for anticounterfeiting, optoelectronics and bioassay applications; however, the realization of Ex-de fluorescence, independent of aggregation states, remains a challenge. We herein report a photoinduced electron transfer (PeT) strategy to design Ex-de fluorescence materials by manipulating the relaxation pathways of multiple excited states. As expected, the o-carborane dyad presents a clear Ex-de fluorescence colour in the aggregated states, resulting from the tunable relative intensity of the dual-fluorescence spectra. Taking TP[1]B as an example, the amorphous powders emitted bright blue-violet, white and yellow colours under 390 nm, 365 nm and 254 nm UV illumination, respectively. Importantly, multicolour, flexible and transparent films as well as an anticounterfeiting application using this o-carborane dyad are demonstrated.

14.
Exp Eye Res ; 214: 108852, 2022 01.
Artigo em Inglês | MEDLINE | ID: mdl-34801535

RESUMO

Microglia and its interaction with Müller cells are responsible to retinal surveillance during retinal neurodegeneration, however, the role and mechanism of microglia-derived tumor necrosis factor (TNF)-α in the activation of retinal Müller cells have not been fully elucidated. In the present study, primary microglia and Müller cells were isolated from newborn Sprague-Dawley (SD) rats with purities of 88.2 ± 6.2% and 92.2 ± 2.2%, respectively. By performing immunofluorescence and Western blot analysis, we found that TNF receptor (TNFR)-1 and TNFR2 were expressed in Müller cells. After co-cultured with microglia-conditioned medium (MCM), the elevated mRNA levels of glial fibrillary acidic protein (GFAP), proinflammatory factors (TNF-α, IL-1ß, CXCL-1, CSF-1, NOS2, COX2) and decreased CNTF mRNA levels were found in Müller cells. However, pretreatment with R-7050 (a TNF-α receptor inhibitor) or anti-TNFR1 significantly abrogated the changes. Simultaneously, pretreatment with anti-TNFR2 slightly inhibited the expression of GFAP in MCM-incubated Müller cells. Meanwhile, anti-TNFR1 treatment reversed the increased expression of CSF-1 and IL-1ß induced by TNF-α. Compared to the control groups, the phosphorylation of NF-κB P65, MAPK P38 and ERK1/2 in TNF-α-treated Müller cells was significantly increased. Nevertheless, pretreatment with anti-TNFR1 inhibited the phosphorylation of NF-κB P65 and MAPK p38, especially NF-κB P65. Additionally, pretreatment with Bay117082 (an NF-κB inhibitor) also significantly inhibited NF-κB P65 phosphorylation and GFAP expression. Moreover, anti-TNFR1 and Bay117082 treatment reduced NF-κB P65 phosphorylation of Müller cells induced by MCM. These results suggested that microglia-derived TNF-α served as a vital role in regulating Müller cells activation during retinal neurodegeneration.


Assuntos
Células Ependimogliais/metabolismo , Microglia/metabolismo , NF-kappa B/metabolismo , Receptores Tipo I de Fatores de Necrose Tumoral/metabolismo , Fator de Necrose Tumoral alfa/fisiologia , Animais , Animais Recém-Nascidos , Western Blotting , Células Cultivadas , Técnicas de Cocultura , Meios de Cultivo Condicionados , Células Ependimogliais/patologia , Técnica Indireta de Fluorescência para Anticorpo , Proteína Glial Fibrilar Ácida/genética , Proteína Glial Fibrilar Ácida/metabolismo , Gliose/etiologia , Gliose/patologia , Fosforilação , RNA Mensageiro/genética , Ratos , Ratos Sprague-Dawley , Reação em Cadeia da Polimerase em Tempo Real , Receptores Tipo II do Fator de Necrose Tumoral/metabolismo , Transdução de Sinais , Fator de Transcrição RelA/metabolismo
15.
J Hazard Mater ; 424(Pt B): 127506, 2022 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-34666294

RESUMO

This study proposes a method to activate O2 by accelerating the corrosion process for zero-valent zinc (ZVZ) with the assistance of Cu(II), promoting the consecutive production of reactive oxygen species. The mechanisms for reactive oxygen species generation are clarified with metronidazole (MTZ) as the targeted pollutant. The outcome suggests the association of Cu(Ⅱ) and ZVZ presents an apparent cooperative activity, an enhancement of 85% in MTZ removal is attained for the ZVZ/Cu(Ⅱ) system after 10 min compared to that for ZVZ. Analysis of the mechanisms involved indicates that this improvement is due to the addition of Cu(Ⅱ), which can accelerate the corrosion of ZVZ. In addition, quenching experiments and electron paramagnetic resonance (EPR) technology show that superoxide radicals (·O2-) result in rapid MTZ degradation. The primary component that is liable for O2 activation and a certain amount of H2O2 generation is verified to be ZVZ. Moreover, Cu(I) is detected in the ZVZ/Cu(Ⅱ) system, which arises from a direct reduction pathway driven by ZVZ and an indirect reduction pathway driven by active hydrogen atoms.


Assuntos
Peróxido de Hidrogênio , Zinco , Cobre , Espectroscopia de Ressonância de Spin Eletrônica , Oxirredução , Espécies Reativas de Oxigênio
16.
ACS Omega ; 6(47): 31578-31594, 2021 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-34869983

RESUMO

The Taodonggou group of Middle Permian is an important source rock in Taibei sag of Turpan-Hami basin. Due to its deep burial, drilling has only been revealed in recent years. Based on organic petrology and organic geochemistry experiments, this paper studies the organic petrology, organic geochemistry, sedimentary environment, and hydrocarbon generation potential of source rocks in Taibei sag, Turpan-Hami basin, and reveals the influence of the sedimentary environment on the organic matter abundance of source rocks. The results are as follows: (1) The organic matter of the Middle Permian source rocks in Taibei sag of Turpan-Hami basin is mainly sapropelite and exinite. The vitrinite is mainly vitrodetrinite, and the exinite is mainly lamalginiite. (2) The total organic carbon content value is 0.55-6.08 wt %, and the average value is 2.58 wt %. The PG value ranges from 0.78 mg HC/g to 30.86 mg HC/g, and the average value is 4.88 mg HC/g. Chloroform asphalt "A" is 0.046-0.8767 wt %, and the average value is 0.285 wt %. The types of organic matter are mainly III and II-III, and the R o value is 0.628-1.49 wt % (average = 0.988 wt %). The T max distribution is 329-465 °C. The average temperature is 434.7 °C, which is in the mature stage (oil window stage). The Middle Permian source rocks are mainly very good to excellent source rocks with a good hydrocarbon generation potential. (3) The source rocks are deposited in a semihumid and semiarid climate. Organic matter is input as a mixed source. The early and late stages is dominated by terrestrial higher plants. The middle stage is dominated by lower aquatic organisms, and the sedimentary environment consists of weak reduction and weak oxidation environments. (4) In the study area, the abundance of organic matter has a weak negative correlation with CPI and a positive correlation with Pr/Ph and ∑C21-/∑C22+. Under the coaction of paleoclimate, organic matter input, and redox environment, the enrichment model of organic matter with high productivity and weak oxidation environment characteristics can also form excellent source rocks. This study is of great significance and provides theoretical guidance for the exploration of deep oil and gas resources.

17.
Eur J Public Health ; 31(6): 1204-1210, 2021 12 01.
Artigo em Inglês | MEDLINE | ID: mdl-34597361

RESUMO

BACKGROUND: This study aimed to investigate associations between health indicators and sleep duration in the general population. METHODS: This cross-sectional data from the National Health and Nutrition Examination Survey. Self-reported sleep duration was classified into short sleep (<7 h/day), regular sleep (7-8 h/day) and long sleep duration (>8 h/day). Health indicators included lifestyle indicators (smoking, alcohol use and physical inactivity), general health indicators (waist circumference and self-reported health condition) and chronic conditions [overweight/obesity, hypertension, diabetes, high cholesterol, chronic low back pain (CLBP) and oral health problems]. A series of multinomial logistic regression analysis were performed, controlling for confounders (age, sex, marital status, ethnic background, education level and poverty-to-income ratio). RESULTS: Data of 12 835 participants were analyzed. The mean (SD) age of participants was 50.0 (±17.4) years, and 50.6% were women. After adjusting for all health indicators, current smoking (OR: 1.37; 95% CI: 1.17-1.61), a poor (OR: 1.52; 95% CI: 1.23-1.88) health condition, CLBP (OR: 1.40; 95% CI: 1.16-1.69) and oral health problems (OR: 1.28; 95% CI: 1.10-1.49) were associated with short sleep duration. No independent association with long sleep duration was observed in this study. CONCLUSIONS: The results confirm that lifestyle indicators (current smoking and physical inactivity), general health indicators (self-reported health condition) and presence of some chronic conditions (CLBP and oral health problems) are associated with short sleep duration. The results did not confirm that any health indicator was associated with long sleep duration.


Assuntos
Sobrepeso , Sono , Adulto , Idoso , Estudos Transversais , Feminino , Humanos , Pessoa de Meia-Idade , Inquéritos Nutricionais , Estados Unidos/epidemiologia , Circunferência da Cintura
18.
BMC Endocr Disord ; 21(1): 215, 2021 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-34711211

RESUMO

BACKGROUND: This study aimed to investigate the differences in oxidative stress (OS) levels represented by 8-iso-prostaglandin F2α (8-iso-PGF2α) and analyze its correlation with the intra-abdominal fat (IAF) area and the glycolipid index. METHODS: We recruited a total of 160 eligible subjects. According to the blood glucose levels and the T2DM duration, subjects were divided into three groups: Type 2 Diabetes (T2DM) group, Prediabetic group, and Normal glucose-tolerance (NC) group, containing 66, 41, 53 patients, respectively. T2DM groups were additionally divided into a new-onset T2DM group including 29 patients and a non-new-onset T2DM group including 37 patients. General clinical data and biochemical indicators were collected. Intra-abdominal fat (IAF) was measured by MRI. 8-iso-PGF2α was measured by ELISA. RESULTS: Compared with the NC group, levels of systolic blood pressure (SBP), waist-to-hip ratio (WHR), FBG, 2 h postprandial glycemia(2hPG), 2 h insulin (2 h INS), IAF area, HOMA-IR, and 8-iso-PGF2α increased, and high-density lipoprotein cholesterol (HDL-C) decreased in T2DM groups and Prediabetic group (P < 0.05). The 2 h INS level was the highest in the Prediabetic group; 2hPG, and IAF area were the highest in the new-onset T2DM group; WHR, FBG, HOMA-IR and 8-iso-PGF2α were the highest in the non-new-onset T2DM group. Multiple stepwise regression analysis identified IAF area and FBG as the strongest and independent determinant of 8-iso-PGF2α (P < 0.01). CONCLUSIONS: In various glycometabolism populations, 8-iso-PGF2α is significantly correlated with FBG and IAF, this suggests that high blood glucose and abdominal obesity can increase the damage related to the OS in vivo.


Assuntos
Gordura Abdominal/diagnóstico por imagem , Diabetes Mellitus Tipo 2/sangue , Dinoprosta/análogos & derivados , Estresse Oxidativo , Estado Pré-Diabético/sangue , Idoso , Glicemia , Estudos de Casos e Controles , Diabetes Mellitus Tipo 2/diagnóstico por imagem , Dinoprosta/sangue , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Estado Pré-Diabético/diagnóstico por imagem
19.
Dis Markers ; 2021: 2863856, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34484467

RESUMO

Angiopoietin-like 3 (ANGPTL3), which is involved in new blood vessel growth, has been reported to exhibit an abnroaml expression in many different cancers. However, the expressing pattern and functions of ANGPTL3 renal cell carcinoma (RCC) were rarely reported. In this study, we observed that ANGPTL3 expression was distinctly downregulated in both RCC specimens from TCGA datasets and cell lines. Survival assays also revealed that patients with low ANGPTL3 expression exhibited a shorter overall survival and disease-free survival than those with high ANGPTL3 expression. Cell counting kit-8 (CCK-8) assay, Colony formation assay, and flow cytometry showed that overexpression of ANGPTL3 distinctly suppressed the proliferation of RCC cells, and promoted apoptosis. Transwell assays and Wound healing assays revealed that ANGPTL3 upregulation suppressed the migration and invasion of RCC cells. Then, we explored whether ANGPTL3 dysregulation influenced the alteration of Wnt/ß-catenin signaling using TOP/FOP flash reporter assays and western blot. The results showed that overexpression of ANGPTL3 distinctly suppressed the activity of Wnt/ß-catenin signaling. Overall, our results confirmed that overexpression of ANGPTL3 was related to the malignancy and good prognosis of RCC patients, and ANGPTL3 upregulation inhibited the tumor proliferation and metastasis via the Wnt/ß-catenin pathway. ANGPTL3 may be a novel therapeutic target and a prognostic biomarker for RCC patients.


Assuntos
/metabolismo , Biomarcadores Tumorais/metabolismo , Carcinoma de Células Renais/patologia , Regulação Neoplásica da Expressão Gênica , Neoplasias Renais/patologia , Proteína Wnt1/metabolismo , beta Catenina/metabolismo , /genética , Apoptose , Biomarcadores Tumorais/genética , Carcinoma de Células Renais/genética , Carcinoma de Células Renais/metabolismo , Movimento Celular , Proliferação de Células , Humanos , Neoplasias Renais/genética , Neoplasias Renais/metabolismo , Prognóstico , Taxa de Sobrevida , Células Tumorais Cultivadas , Proteína Wnt1/genética , beta Catenina/genética
20.
Angew Chem Int Ed Engl ; 60(46): 24424-24429, 2021 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-34523773

RESUMO

Conjugated organic radical polymers with stable radical features are difficult to design because the π conjugation in the polymer backbones makes the radicals readily delocalize and tend to undergo covalent bonding processes. In this work, we report an electronic isolation strategy to design stable porous radical polymers by homocoupling reaction from a meta-position active monomer. The meta linkage ensures less conjugation in the polymer skeletons, localizes the resonant radicals, and prevents them from recombination. The resulting porous radical polymer exhibits exceptional radical characters with ultralow band gap of 0.68 eV, strong yet extended UV/Vis-NIR absorption up to 1800 nm, and high spin density. The above features make the polymer very promising in the photothermal conversion with record-high photothermal temperature increment of ≈∼240 °C and striking solar-driven water evaporation efficiency of 96.8 %. Our results demonstrate the feasibility of electronic isolation of radicals for producing outstanding photothermal materials.

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