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1.
Biomarkers ; : 1-8, 2020 Mar 06.
Artigo em Inglês | MEDLINE | ID: mdl-32141338

RESUMO

Background: The number of patients suffering from coronary heart disease with cancer is rising. There is scarce evidence concerning the biomarkers related to prognosis among patients undergoing percutaneous coronary intervention (PCI) with cancer. Thus, the aim of this study was to investigate the association between red blood cell distribution width (RDW) and prognosis in this population.Methods: A total of 172 patients undergoing PCI with previous history of cancer were enrolled in this retrospective study. The endpoint was long-term all-cause mortality. According to tertiles of RDW, the patients were classified into three groups: Tertile 1 (RDW <12.8%), Tertile 2 (RDW ≥12.8% and <13.5%) and Tertile 3 (RDW ≥13.5%).Results: During an average follow-up period of 33.3 months, 29 deaths occurred. Compared with Tertile 3, mortality of Tertile 1 and Tertile 2 was significantly lower in the Kaplan-Meier analysis. In multivariate Cox regression analysis, RDW remained an independent risk factor of mortality (HR: 1.938, 95% CI: 1.295-2.655, p < 0.001). The all-cause mortality in Tertile 3 was significantly higher than that in Tertile 1 (HR: 5.766; 95% CI: 1.426-23.310, p = 0.014).Conclusions: An elevated RDW level (≥13.5%) was associated with long-term all-cause mortality among patients undergoing PCI with previous history of cancer.

2.
Biosci Rep ; 39(8)2019 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-31383787

RESUMO

Aim: To explore clinical factors associated with extent of liver regeneration after hemihepatectomy to treat hepatocellular carcinoma (HCC).Methods: Future liver remnant volume (as a percentage of functional liver volume, %FLRV) and remnant liver volume were measured preoperatively and at 1, 5, 9, and 13 weeks postoperatively.Results: After hepatectomy, 1 of 125 patients (0.8%) died within 3 months, 13 (10.4%) experienced liver failure, and 99 (79.2%) experienced complications. %FLRV was able to predict liver failure with an area under the receiver operating characteristic curve of 0.900, and a cut-off value of 42.7% showed sensitivity of 85.7% and specificity of 88.6%. Postoperative median growth ratio was 21.3% at 1 week, 30.9% at 5 weeks, 34.6% at 9 weeks, and 37.1% at 13 weeks. Multivariate analysis identified three predictors associated with liver regeneration: FLRV < 601 cm3, %FLRV, and liver cirrhosis. At postoperative weeks (POWs) 1 and 5, liver function indicators were significantly better among patients showing high extent of regeneration than among those showing low extent, but these differences disappeared by POW 9.Conclusions: FLRV, %FLRV, and liver cirrhosis strongly influence extent of liver regeneration after hepatectomy. %FLRV values below 42.7% are associated with greater risk of post-hepatectomy liver failure.

3.
Nat Commun ; 10(1): 3155, 2019 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-31316076

RESUMO

Developing broadband and strong visible-light-absorbing photosensitizer is highly desired for dramatically improving the utilization of solar energy and boosting artificial photosynthesis. Herein, we develop a facile strategy to co-sensitize Ir-complex with Coumarins and boron dipyrromethene to explore photosensitizer with a broadband covering ca. 50% visible light region (Ir-4). This type of photosensitizer is firstly introduced into water splitting system, exhibiting significantly enhanced performance with over 21 times higher than that of typical Ir(ppy)2(bpy)+, and the turnover number towards Ir-4 reaches to 115840, representing the most active sensitizer among reported molecular photocatalytic systems. Experimental and theoretical investigations reveal that the Ir-mediation not only achieves a long-lived boron dipyrromethene-localized triplet state, but also makes an efficient excitation energy transfer from Coumarin to boron dipyrromethene to trigger the electron transfer. These findings provide an insight for developing broadband and strong visible-light-absorbing multicomponent arrays on molecular level for efficient artificial photosynthesis.

4.
Opt Express ; 27(11): 15382-15390, 2019 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-31163735

RESUMO

We study the nonreciprocal transmission and the fast-slow light effects in a cavity optomechanical system, in which the cavity supports a clockwise and a counter-clockwise circulating optical mode; both the modes are driven simultaneously by a strong pump field and a weak signal field. We find that the system reveals a nonreciprocal transmission of the signal fields when the intrinsic photon loss of the cavity is equal to the external coupling loss of the cavity. However, when the intrinsic photon loss is much less than the external coupling loss, the nonreciprocity about the transmission properties almost disappears, the nonreciprocity is shown in the group delay properties of the signal fields, and the system exhibits a nonreciprocal fast-slow light propagation phenomenon.

5.
Angew Chem Int Ed Engl ; 58(28): 9491-9495, 2019 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-31066965

RESUMO

Improving the stability of lead halide perovskite quantum dots (QDs) in a system containing water is the key for their practical application in artificial photosynthesis. Herein, we encapsulate low-cost CH3 NH3 PbI3 (MAPbI3 ) perovskite QDs in the pores of earth-abundant Fe-porphyrin based metal organic framework (MOF) PCN-221(Fex ) by a sequential deposition route, to construct a series of composite photocatalysts of MAPbI3 @PCN-221(Fex ) (x=0-1). Protected by the MOF the composite photocatalysts exhibit much improved stability in reaction systems containing water. The close contact of QDs to the Fe catalytic site in the MOF, allows the photogenerated electrons in the QDs to transfer rapidly the Fe catalytic sites to enhance the photocatalytic activity for CO2 reduction. Using water as an electron source, MAPbI3 @PCN-221(Fe0.2 ) exhibits a record-high total yield of 1559 µmol g-1 for photocatalytic CO2 reduction to CO (34 %) and CH4 (66 %), 38 times higher than that of PCN-221(Fe0.2 ) in the absence of perovskite QDs.

6.
Opt Express ; 27(5): 7160-7173, 2019 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-30876285

RESUMO

In spectroscopy, the compositional analysis of the spectrum is important, such as extracting information about the species of spectral objects contributing to spectral data from an emission spectrum of photon energy. A quantitative spectral component analysis method based on Maximum Likelihood Estimation using Expectation Maximization (MLEM) is developed, which could quantitatively decompose out the components of the measured spectrum of low counts and surpass conventional techniques which belong to classification or regression. Abundant experimental and simulated spectra data on gamma-ray spectrum of radionuclides are presented to demonstrate and evaluate this method, while the ingredient radionuclides in the mixed spectrum are identified accurately with high precision. It will be a powerful and alternative method recommended for the circumstances needing fast and quantitative spectral analysis, including radionuclide identification (gamma-ray spectra), biomass or mineral composition (near-infrared spectra), laser-induced breakdown spectra and other spectroscopy scenarios.

7.
ACS Appl Mater Interfaces ; 11(3): 2655-2661, 2019 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-29697952

RESUMO

Hydrogen production through artificial photosynthesis has been regarded as a promising strategy for dealing with energy shortage and environmental problems. In this work, graphdiyne (GD) was first introduced to the visible-light catalytic system for hydrogen production, in which a CdS/GD heterojunction was prepared through a simple in situ growth process by adding Cd(AcO)2 into a dimethyl sulfoxide (DMSO) solution containing GD substrate. The as-prepared CdS/GD heterojunction exhibits much higher performance for photocatalytic hydrogen evolution compared to that of pristine GD and CdS nanoparticles. The photocatalytic performance of CdS/GD heterostructure containing 2.5 wt % of GD (GD2.5) is 2.6 times higher than that of the pristine CdS nanoparticles. The enhanced catalytic performance can be ascribed to the formation of CdS/GD heterojunction, in which the presence of GD can not only stabilize CdS nanoparticles by preventing the agglomeration of CdS nanoparticles but also act as a photogenerated hole transfer material for efficiently separating photogenerated electron-hole pairs in CdS. Accordingly, this work provides the potential of GD-derived materials for solar energy conversion and storage.

8.
iScience ; 23(1): 100793, 2019 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-31958757

RESUMO

Quinolones and isoquinolones are of interest to pharmaceutical industry owing to their potent biological activities. Herein, we first encapsulated sub-nm Pt nanoclusters into Zr-porphyrin frameworks to afford an efficient photocatalyst Pt0.9@PCN-221. This catalyst can dramatically promote electron-hole separation and 1O2 generation to achieve synergistic effect first in the metal-organic framework (MOF) system, leading to the highest activity in photosynthesis of (iso)quinolones in >90.0% yields without any electronic sacrificial agents. Impressively, Pt0.9@PCN-221 was reused 10 times without loss of activity and can catalyze gram-scale synthesis of 1-methyl-5-nitroisoquinolinone at an activity of 175.8 g·gcat-1, 22 times higher than that of PCN-221. Systematic investigations reveal the contribution of synergistic effect of photogenerated electron, photogenerated hole, and 1O2 generation for efficient photo-oxidation, thus highlighting a new strategy to integrate multiple functional components into MOFs to synergistically catalyze complex photoreactions for exploring biologically active heterocyclic molecules.

9.
Opt Express ; 26(22): 29099-29109, 2018 Oct 29.
Artigo em Inglês | MEDLINE | ID: mdl-30470076

RESUMO

We study the phase sensitivity of an SU(1,1) interferometer from two aspects, i.e., the phase estimation determined by the error propagation formula and that by the quantum Cramér-Rao bound (QCRB). The results show that the phase sensitivity by using the intensity detection reaches the sub-shot-noise limit with a coherent state and an m-photon-added squeezed vacuum state (m-PA-SVS) as inputs. The phase sensitivity gradually approaches the Heisenberg limit for increasing m, and the ultimate phase precision improves with the increase of m. In addition, the QCRB can be saturated by the intensity detection with inputting the m-PA-SVS.

10.
Adv Sci (Weinh) ; 5(10): 1800949, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30356966

RESUMO

Industrial application of overall water splitting requires developing readily available, highly efficient, and stable oxygen evolution electrocatalysts that can efficiently drive large current density. This study reports a facile and practical method to fabricate a non-noble metal catalyst by directly growing a Co-Fe Prussian blue analogue on a 3D porous conductive substrate, which is further phosphorized into a bifunctional Fe-doped CoP (Fe-CoP) electrocatalyst. The Fe-CoP/NF (nickel foam) catalyst shows efficient electrocatalytic activity for oxygen evolution reaction, requiring low overpotentials of 190, 295, and 428 mV to achieve 10, 500, and 1000 mA cm-2 current densities in 1.0 m KOH solution. In addition, the Fe-CoP/NF can also function as a highly active electrocatalyst for hydrogen evolution reaction with a low overpotential of 78 mV at 10 mA cm-2 current density in alkaline solution. Thus, the Fe-CoP/NF electrode with meso/macropores can act as both an anode and a cathode to fabricate an electrolyzer for overall water splitting, only requiring a cell voltage of 1.49 V to afford a 10 mA cm-2 current density with remarkable stability. This performance appears to be among the best reported values and is much better than that of the IrO2-Pt/C-based electrolyzer.

11.
Angew Chem Int Ed Engl ; 57(49): 16067-16071, 2018 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-30338921

RESUMO

The removal of C2 H2 and C2 H6 from C2 H4 streams is of great significance for feedstock purification to produce polyethylene and other commodity chemicals but the simultaneous adsorption of C2 H6 and C2 H2 over C2 H4 from a ternary mixture has never been realized. Herein, a robust metal-organic framework, TJT-100, was designed and synthesized, which demonstrates remarkably selective adsorption of C2 H2 and C2 H6 over C2 H4 . Breakthrough experiments show that TJT-100 can be used as an adsorbent for high-performance purification of C2 H4 from a ternary mixture of C2 H2 /C2 H4 /C2 H6 (0.5:99:0.5) to afford a C2 H4 purity greater than 99.997 %, beyond that required for ethylene polymerization. Computational studies reveal that the uncoordinated carboxylate oxygen atoms and coordinated water molecules pointing towards the pore can trap C2 H2 and C2 H6 through the formation of multiple C-H⋅⋅⋅O electrostatic interactions, while the corresponding C2 H4 -framework interaction is unfavorable.

12.
Exp Ther Med ; 16(5): 4005-4009, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30344678

RESUMO

Inflammation serves a critical role in the pathophysiology of intracerebral hemorrhage (ICH)-induced brain injury. Eupatilin, a pharmacologically active flavone derived from Artemisia sp., has been reported to have antioxidant, anti-inflammatory, anti-allergic and antitumor activities. However, the effect of eupatilin in ICH has not been well studied. The aim of the present study was to investigate the effect of eupatilin on ICH-induced microglial inflammation. The MTT and Transwell migration assay results revealed that eupatilin significantly inhibited microglial migration. It also decreased the production of inflammatory cytokines in erythrocyte lysis-induced BV2 cells, as well as the level of intracellular reactive oxygen species. The anti-inflammatory mechanism of eupatilin was also investigated using ELISAs and western blotting and the results demonstrated that eupatilin was able to inhibit erythrocyte lysis-induced NF-κB activation in BV2 cells. Taken together, the results of the present study suggest that eupatilin serves neurological protective effects via inhibiting microglial inflammation, providing an experimental basis for the use of eupatilin as a therapeutic target for ICH.

13.
Sci Rep ; 8(1): 13074, 2018 08 30.
Artigo em Inglês | MEDLINE | ID: mdl-30166568

RESUMO

The aim of this study was to investigate the diagnostic value of the platelet count-to-spleen volume ratio (PSR) for diagnosing hepatic fibrosis in patients with hepatocellular carcinoma (HCC). In this interim analysis of an on-going prospective study, 117 patients with HCC and with or without cirrhosis or fibrosis in different stages were analyzed. Fibrosis staging negatively correlated with PSR and the liver volume-to-spleen volume ratio (LSR), while it positively correlated with aspartate aminotransferase-to-platelet ratio index (APRI), Frons' index, S-index and a fibrosis index based on four factors (FIB-4). The area under the receiver operating characteristic curve (AUROC) was significantly larger for PSR (0.777) than LSR (0.633, P = 0.002). Among patients with significant fibrosis, AUROC for PSR did not differ significantly from the AUROCs for APRI (0.789, P = 0.825), Frons' index (0.674, P = 0.102), FIB-4 (0.704, P = 0.251) or S-index (0.696, P = 0.204). Among patients with severe fibrosis, AUROC was significantly higher for PSR (0.808) than for LSR (0.685, P = 0.003), Frons' index (0.673, P = 0.014), FIB-4 (0.684, P = 0.029), or S-index (0.672, P = 0.016); in contrast, the AUROC for PSR was not significantly different from that for APRI (0.739, P = 0.215). Among patients with cirrhosis, AUROC was significantly higher for PSR (0.814) than for LSR (0.671, P = 0.001) or S-index (0.679, P = 0.022), while the AUROC for PSR did not differ significantly from those for APRI (0.711, P = 0.105), Frons' index (0.722, P = 0.061) or FIB-4 (0.708, P = 0.079). Our results suggest that PSR may be a useful non-invasive model for diagnosing liver fibrosis stage in patients with HCC in China.


Assuntos
Carcinoma Hepatocelular/diagnóstico , Cirrose Hepática/diagnóstico , Neoplasias Hepáticas/diagnóstico , Carcinoma Hepatocelular/patologia , Feminino , Humanos , Fígado/diagnóstico por imagem , Fígado/patologia , Cirrose Hepática/patologia , Neoplasias Hepáticas/patologia , Masculino , Pessoa de Meia-Idade , Modelos Biológicos , Estadiamento de Neoplasias , Curva ROC , Baço/diagnóstico por imagem , Baço/patologia
14.
Br J Cancer ; 119: 182-192, 2018 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-29937544

RESUMO

BACKGROUND: Surgery combined with new adjuvant chemotherapy is the primary treatment for early stage invasive and advanced stage breast cancer. Growing evidence indicates that patients with ERα-positive breast cancer show poor response to chemotherapeutics. However, ERα-mediated drug-resistant mechanisms remain unclear. METHODS: Levels of WW domain-binding protein 2 (WBP2) and drug-resistant gene were determined by western blotting and RT-PCR, respectively. Cell viability was measured by preforming MTT assay. CD243 expression and apoptosis rate were evaluated by flow cytometry. Interactions of WBP2/ERα and ERα/MDR1 were detected by co-immunoprecipitation and chromatin immunoprecipitation (ChIP) assay, respectively. RESULTS: There was an intrinsic link between WBP2 and ERα in drug-resistant cancer cells. Upregulation of WBP2 in MCF7 cells increased the chemoresistance to doxorubicin, while RNAi-mediated knockdown of WBP2 in MCF7/ADR cells sensitised the cancer cells to doxorubicin. Further investigation in in vitro and in vivo models demonstrated that WBP2 expression was directly correlated with MDR1, and WBP2 could directly modulate MDR1 transcription through binding to ERα, resulting in increased chemotherapy drug resistance. CONCLUSIONS: Our finding provides a new mechanism for the chemotherapy response of ERα-positive breast tumours, and WBP2 might be a key molecule for developing new therapeutic strategies to treat chemoresistance in breast cancer patients.


Assuntos
Proteínas Adaptadoras de Transdução de Sinal/fisiologia , Neoplasias da Mama/tratamento farmacológico , Receptor alfa de Estrogênio/fisiologia , Subfamília B de Transportador de Cassetes de Ligação de ATP/genética , Proteínas Adaptadoras de Transdução de Sinal/genética , Animais , Apoptose , Neoplasias da Mama/patologia , Doxorrubicina/uso terapêutico , Resistencia a Medicamentos Antineoplásicos , Receptor alfa de Estrogênio/genética , Feminino , Humanos , Células MCF-7 , Camundongos , Camundongos Endogâmicos BALB C , Transcrição Genética
15.
Cancer Res ; 78(17): 4853-4864, 2018 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-29898994

RESUMO

p62 is a receptor that facilitates selective autophagy by interacting simultaneously with cargoes and LC3 protein on the autophagosome to maintain cellular homeostasis. However, the regulatory mechanism(s) behind this process and its association with breast cancer remain to be elucidated. Here, we report that Flightless-I (FliI), a novel p62-interacting protein, promotes breast cancer progression by impeding selective autophagy. FliI was highly expressed in clinical breast cancer samples, and heterozygous deletion of FliI retarded the development of mammary tumors in PyVT mice. FliI induced p62-recruited cargoes into Triton X-100 insoluble fractions (TI) to form aggregates, thereby blocking p62 recognition of LC3 and hindering p62-dependent selective autophagy. This function of Flil was reinforced by Akt-mediated phosphorylation at Ser436 and inhibited by phosphorylation of Ulk1 at Ser64. Obstruction of autophagic clearance of p62-recruited cargoes by FliI was associated with the accumulation of oxidative damage on proteins and DNA, which could contribute to the development of cancer. Heterozygous knockout of FliI facilitated selectively autophagic clearance of aggregates, abatement of ROS levels, and protein oxidative damage, ultimately retarding mammary cancer progression. In clinical breast cancer samples, Akt-mediated phosphorylation of FliI at Ser436 negatively correlated with long-term prognosis, while Ulk1-induced FliI phosphorylation at Ser64 positively correlated with clinical outcome. Together, this work demonstrates that FliI functions as a checkpoint protein for selective autophagy in the crosstalk between FliI and p62-recruited cargoes, and its phosphorylation may serve as a prognostic marker for breast cancer.Significance: Flightless-I functions as a checkpoint protein for selective autophagy by interacting with p62 to block its recognition of LC3, leading to tumorigenesis in breast cancer.Cancer Res; 78(17); 4853-64. ©2018 AACR.


Assuntos
Neoplasias da Mama/genética , Carcinogênese/genética , Proteínas dos Microfilamentos/genética , Proteínas Associadas aos Microtúbulos/genética , Proteínas de Ligação a RNA/genética , Receptores Citoplasmáticos e Nucleares/genética , Adulto , Idoso , Animais , Autofagossomos/metabolismo , Autofagossomos/patologia , Autofagia/genética , Proteína Homóloga à Proteína-1 Relacionada à Autofagia/genética , Mama/metabolismo , Mama/patologia , Neoplasias da Mama/patologia , Progressão da Doença , Feminino , Humanos , Peptídeos e Proteínas de Sinalização Intracelular/genética , Camundongos , Pessoa de Meia-Idade , Fosforilação , Ligação Proteica/genética
16.
Opt Express ; 26(9): 11915-11927, 2018 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-29716108

RESUMO

Quantum squeezing, as a typical quantum effect, is an important resource for many applications in quantum technologies. Here we propose a scheme for generating quantum squeezing, including the ponderomotive squeezing and the mechanical squeezing, in an optomechanical system, in which the radiation-pressure coupling and the mechanical spring constant are modulated periodically. In this system, the radiation-pressure interaction can be enhanced remarkably by the modulation-induced mechanical parametric amplification. Moreover, the effective phonon noise can be suppressed completely by introducing a squeezed vacuum reservoir. This ultimately leads to that our scheme can achieve a controllable quantum squeezing. Numerical calculations show that our scheme is experimentally realizable with current technologies.

17.
Chem Sci ; 9(5): 1375-1384, 2018 Feb 07.
Artigo em Inglês | MEDLINE | ID: mdl-29675186

RESUMO

The development of highly efficient, low-cost and stable electrocatalysts for overall water splitting is highly desirable for the storage of intermittent solar energy and wind energy sources. Herein, we show for the first time that nickel can be extracted from NiFe-layered double hydroxide (NiFe-LDH) to generate an Ni2P@FePO x heterostructure. The Ni2P@FePO x heterostructure was converted to an Ni2P@NiFe hydroxide heterostructure (P-NiFe) during water splitting, which displays high electrocatalytic performance for both the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) in 1.0 M KOH solution, with an overpotential of 75 mV at 10 mA cm-2 for HER, and overpotentials of 205, 230 and 430 mV at 10, 100 and 1000 mA cm-2 for OER, respectively. Moreover, it could afford a stable current density of 10 mA cm-2 for overall water splitting at 1.51 V in 1.0 M KOH with long-term durability (100 h). This cell voltage is among the best reported values for bifunctional electrocatalysts. The results of theoretical calculations demonstrate that P-NiFe displays optimized adsorption energies for both HER and OER intermediates at the nickel active sites, thus dramatically enhancing its electrocatalytic activity.

18.
Cell Death Dis ; 9(3): 347, 2018 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-29497031

RESUMO

WW domain-binding protein 2 (WBP2) has been demonstrated as oncogenic in breast cancer. Many studies have revealed the WBP2 gene as a high-risk gene for leukoariaosis and cerebral white matter lesions is important in the pathologic stage of glioma development. This study aimed to illustrate the underlying mechanism by which WBP2 regulates the process of glioma development. The expression pattern of WBP2 in several tumor cells was determined, clarifying the carcinogenic action of WBP2 in glioma cells. Overexpression of WBP2 in glioma cells promoted cell proliferation and migration, and the number of S-phase cells, whereas the depletion of WBP2 by RNAi-mediated knockdown restrained cell growth and cell cycle progression. Upregulation of WBP2 significantly enhanced the tumorigenic ability of U251 cells in vivo. MS/GST pulldown assay identified α-enolase (ENO1) and Homer protein homolog 3 (Homer3) as novel potent interaction partners of WBP2. Knockdown of ENO1 or Homer3 allowed cell growth and migration to return to normal levels. Furthermore, in vitro and in vivo experiments indicated that the oncogenic role of WBP2 in glioma was through modulating ENO1 and glycolysis activity via the ENO1-PI3K/Akt signaling pathway. Collectively, these results reveal that WBP2 plays a vital role in the occurrence and development of glioma, indicating a target gene for glioblastoma treatment.


Assuntos
Proteínas Adaptadoras de Transdução de Sinal/metabolismo , Biomarcadores Tumorais/metabolismo , Neoplasias Encefálicas/metabolismo , Proteínas de Ligação a DNA/metabolismo , Glioma/metabolismo , Camundongos Nus/metabolismo , Fosfopiruvato Hidratase/metabolismo , Proteínas Supressoras de Tumor/metabolismo , Proteínas Adaptadoras de Transdução de Sinal/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Animais , Biomarcadores Tumorais/genética , Neoplasias Encefálicas/genética , Neoplasias Encefálicas/fisiopatologia , Ciclo Celular , Movimento Celular , Proliferação de Células , Proteínas de Ligação a DNA/genética , Feminino , Glioma/genética , Glioma/fisiopatologia , Glicólise , Proteínas de Arcabouço Homer/genética , Proteínas de Arcabouço Homer/metabolismo , Humanos , Masculino , Camundongos , Camundongos Nus/genética , Pessoa de Meia-Idade , Oncogenes , Fosfopiruvato Hidratase/genética , Ligação Proteica , Proteínas Supressoras de Tumor/genética
19.
ACS Appl Mater Interfaces ; 10(9): 8231-8237, 2018 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-29433305

RESUMO

We develop a facile self-template synthetic method to construct hierarchical Co-Se-S-O (CoSe xS2- x@Co(OH)2) nanotubes on a carbon cloth as a self-standing electrode for electrocatalytic oxygen evolution reaction (OER). In the synthetic process, separate selenization and sulfurization on the Co(OH)F precursor in different solvents have played an important role in constructing CoSe xS2- x (Co-Se-S) hierarchical nanotubes, which was further transformed into the nanotube-like Co-Se-S-O via an in situ electrochemical oxidation process. The Co-Se-S-O obtained by the Kirkendall effect through two stepwise anion-exchange reactions represents the first quaternary Co-Se-S-O nanotube array, which dramatically enhances its surface area and conductivity. Further, it only requires low overpotentials of 230 and 480 mV to achieve a 10 mA cm-2 current density. The OER performance of Co-Se-S-O is much more efficient than that of its monochalcogenide counterparts, as well as the commercial benchmark catalyst IrO2.

20.
Colloids Surf B Biointerfaces ; 164: 247-254, 2018 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-29413603

RESUMO

Cathodic polarization antifouling deserves attention because of its environmentally friendly nature and good sustainability. It has been proven that cathodic voltages applied on metal substrates exhibit outstanding antifouling effects. However, most metals immersed in marine environment are protected by insulated anticorrosive coatings, restricting the cathodic polarization applied on metals. This study developed a conducting polypyrrole (PPy)/acrylic resin coating (σ = 0.18 Scm-1), which can be applied in cathodic polarization antifouling. The good stability and electro-activity of PPy in the negative polarity zone in alkalescent NaCl solution were verified by linear sweep voltammetry (LSV), chronoamperometry (CA), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS), demonstrating the feasibility of PPy as cathodic polarization material. Furthermore, the antifouling effects of PPy/acrylicresin coating on 24-h old Escherichia coli bacteria (E. coli) which formed on PPy/acrylic resin-coated plastic plate were measured under different cathodic potentials and treatment time, characterized by fluorescent microscope. The results suggest that at cathodic potential around -0.5 V (vs. saturated calomel electrode (SCE)), there was little trace of attached bacteria on the substrate after 20 min of treatment. PPy/acrylicresin-coated substrates were also subjected to repeated cycles of biofilm formation and electrochemical removal, where high removal efficiencies were maintained throughout the total polarization process. Under these conditions, the generation of hydrogen peroxide is believed to be responsible for the antifouling effects because of causing oxidative damage to cells, suggesting the potential of the proposed technology for application on insulated surfaces in various industrial settings.


Assuntos
Incrustação Biológica , Polímeros/química , Pirróis/química , Biofilmes , Eletricidade , Técnicas Eletroquímicas , Eletrodos , Escherichia coli/citologia , Estudos de Viabilidade , Cinética
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