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1.
Opt Lett ; 46(5): 1069-1072, 2021 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-33649659

RESUMO

In this Letter, we first propose and demonstrate a real-time in-band full duplex (IBFD) transmission system based on adaptive optical self-interference cancellation (OSIC). The field programmable gate array (FPGA) is used for high-speed and real-time orthogonal frequency-division multiplexing (OFDM) transmission. The hybrid criteria regular triangle (RT) algorithm is first proposed to combine signal power and the bit error rate (BER) together as the objective function to realize the adaptive control process. With this algorithm, the real-time adaptive OSIC system is able to converge and fully recover the signal of interest (SOI) within 12 sampling times, which is by far the fastest, to the best of our knowledge, convergence under the real-time transmission scenario. Experiments show that the system can achieve 28 dB cancellation depth across 0-1.45 GHz wideband, and 40 dB cancellation depth at 900 MHz, 2.4 GHz, and 5 GHz, which is the best cancellation performance in current real-time adaptive OSIC schemes and shows the potential of our system in different commercial applications.

2.
AAPS J ; 23(2): 29, 2021 02 12.
Artigo em Inglês | MEDLINE | ID: mdl-33580411

RESUMO

Pancreatic cancer is a highly malignant tumor and one of the primary causes of cancer-related death. Because pancreatic cancer is difficult to diagnose in the early course of the disease, most patients present with advanced lesions at the time of diagnosis, and only 20% of patients are eligible for surgery. Consequently, drug treatment has become extremely important. At present, the main treatment regimens for pancreatic cancer are gemcitabine and the FORFIRINOX and MPACT regimens. However, none of these regimens substantially improves the prognosis of patients with pancreatic cancer. Extensive efforts have been dedicated to the study of pancreatic cancer in recent years. With the development and clinical application of biological targeted drugs, the biological targeted treatment of tumors has been widely accepted. Therefore, this article used relevant clinical trial data to summarize the research progress of traditional chemotherapy drugs and biological targeted drugs for the treatment of pancreatic cancer.

3.
Rheumatol Ther ; 2021 Feb 09.
Artigo em Inglês | MEDLINE | ID: mdl-33559842

RESUMO

INTRODUCTION: The aim of this work is to examine the efficacy and safety of prefilled liquid etanercept-biosimilar Yisaipu versus lyophilized Yisaipu in active ankylosing spondylitis (AS) patients. METHODS: This double-blind, phase III trial with non-inferiority design randomized adult patients with active AS in a 3:1:1 ratio to receive twice-weekly 25-mg prefilled liquid Yisaipu for a total of 48 injections (group I, n = 330), once-weekly 50-mg prefilled liquid Yisaipu for 24 injections (group II, n = 110), or twice-weekly 25-mg lyophilized Yisaipu for 48 injections (group III, n = 110). Both physicians and patients who received 25-mg twice-weekly lyophilized or liquid Yisaipu were blinded to treatment assignment while patients who received 50-mg once-weekly liquid Yisaipu received treatment in an open-label design. In addition, 90 patients in the PK/PD study were randomized in a 1:1:1 ratio to each group. The primary outcome was the proportion of patients who achieved ASAS20 at week 24. RESULTS: A total of 640 subjects were enrolled. The proportion of patients who attained ASAS20 at week 24 was 85.56% in group I, 85.71% in group II, and 83.45% in group III (group I vs. III, P = 0.545; group II vs. III, P = 0.605). The difference between group I and III was 2.10% (95% CI - 5.06%, 9.27%) and 2.26% (95% CI - 6.21%, 10.73%) between group II and III, meeting the non-inferiority threshold (Δ = - 15%) (P < 0.001). Except for a statistical difference between group I (75.83%) and group III at week 8 (64.75%, P = 0.011), there was no statistical difference in the ASAS20 attainment rate among the three groups at other time points. The incidence of serious adverse events was comparable among the three groups (group I, 2.50%, II, 2.86% and III, 1.43%; P > 0.05). No deaths were reported. CONCLUSIONS: Once-weekly 50-mg or twice-weekly 25-mg prefilled liquid Yisaipu is safe and non-inferior to twice-weekly 25-mg lyophilized Yisaipu. TRIAL REGISTRATION: CTR20130124 and NCT04345458.

4.
BMC Musculoskelet Disord ; 22(1): 178, 2021 Feb 13.
Artigo em Inglês | MEDLINE | ID: mdl-33583400

RESUMO

BACKGROUND: Aim of this multicenter, observational, cross-sectional study was to evaluate health-related quality of life (HRQoL) and treatment satisfaction of current medications in Chinese knee OA patients. METHODS: Brief Pain Inventory (BPI), Treatment Satisfaction Questionnaire (TSQM-1.4), and HRQoL (EQ-5D-5L) were assessed in total of 601 OA of knee patients. Impact on QoL (EQ-5D-5L) and treatment satisfaction (TSQM-1.4) by BPI-Severity score (< 4 and ≥ 4) were presented using mean standard deviations (SDs) and were compared using a t-test. For each of self-assessed health EQ-5D-5L and TSQM, a linear regression model was used to estimate the regression coefficient along with corresponding 95% confidence interval (CI) for BPI-Severity. RESULTS: Mean score of EQ-5D-5L of patients with BPI-Severity ≥4 was significantly lower than those with BPI-Severity < 4. All the scores of TSQM in 4 dimensions were lower in patients with BPI-Severity ≥4 than in those with BPI-Severity < 4. Both HRQoL scores and TSQM scores showed a statistically significant decreasing trend with increasing BPI-Severity pain score. CONCLUSION: Chronic knee OA pain has a significant impact on patients' HRQoL. More severe patients with OA were less satisfied with current treatments.

5.
J Nanosci Nanotechnol ; 21(2): 1244-1249, 2021 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-33183468

RESUMO

This article studies the effect of pulmonary ultrasound in the diagnosis and treatment of neonatal pneumonia. In this experiment, 33 children with pneumonia diagnosed and treated in the hospital were selected as the research objects, and all were performed by X-ray examination and lung ultrasound. After the test was completed, the diagnostic accuracy of the two examination methods was analyzed, the performance of the chest X-rays of the children were observed, and the lung ultrasound examination was recorded at the same time. The results showed that the diagnostic accuracy of lung ultrasound examination was 93.00%, which was higher than 75.00% of X-ray examination, and the difference was statistically significant (P < 0.05). In the experiment, the paired chi-square test was performed on the results of LUS and bedside CXR diagnosis of IPN, and the value was 0.687. The two have a good consistency in the diagnosis of IPN in NICU. The Pearson correlation test results of LUS score and neonatal pneumonia case score showed that there was a significant negative correlation between LUS score and neonatal pneumonia case score. The LUS scores between the control group, non-risk recombination, and risk recombination were tested by rank sum test of multiple independent samples. The results showed that the LUS scores of the three groups were statistically significant (P < 0.05). The LUS scores of the risk recombination were significantly higher than the non-risk recombination. Two independent sample rank sum tests were performed between each two groups. After Bonferroni correction of P value, the difference between each group was statistically significant. In the end, we have concluded that for the diagnosis of neonatal pneumonia, pulmonary ultrasound can be used for diagnosis. Combining pulmonary ultrasound with X-rays can improve the diagnosis accuracy of pneumonia. During the treatment, ultrasound is used for dynamic monitoring. By observing the pleural line and pulmonary consolidation it can be used to clarify the treatment effect of children. LUS and bedside CXR have a good agreement for the diagnosis of IPN. The LUS score can effectively assess the severity of IPN. The greater the severity of the disease in children with IPN, the higher the LUS score.

6.
Opt Lett ; 45(23): 6382-6385, 2020 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-33258817

RESUMO

A wideband multipath self-interference cancellation (SIC) system employing both dual-drive Mach-Zehnder modulator-based analog SIC and least mean square (LMS) algorithm-based pre-adaptive filter digital SIC is proposed and demonstrated for the cancellation of multipath self-interference (SI) and facilitation of in-band full-duplex (IBFD) orthogonal frequency-division multiplexing (OFDM) signal transmission. The multipath effect is an unavoidable challenge in SIC due to the dynamic and unpredictable properties in each path, as well as the need for separate matching components for compensating for each path. In this Letter, an LMS algorithm-based adaptive filter is used as a pre-equalizer to adapt and generate the matching signal to the closest approximate of the multipath SI signal. The adaptation is based on the minimization of the error signal generated from the matching signal and multipath SI signal in the LMS algorithm. With the introduction of the LMS adaptive filter to the analog SIC, an additional 9 dB cancellation improvement is obtained, resulting in a total of 32 dB cancellation depth over a cancellation bandwidth of 2.7 GHz at a center frequency of 1.65 GHz. To the best of our knowledge, the achieved performance is by far the widest cancellation bandwidth in a multipath SIC system, which is essential in a large bandwidth and high data rate transmission system. With the help of the proposed LMS adaptive filter digital SIC assisted analog SIC located at the remote node, power-efficient IBFD transmission of an OFDM signal through a 25 km fiber is experimentally demonstrated with a 6 dB bit error rate and 8% error vector magnitude improvements.

7.
BMC Gastroenterol ; 20(1): 398, 2020 Nov 24.
Artigo em Inglês | MEDLINE | ID: mdl-33228549

RESUMO

BACKGROUND: We initiated the first multi-center cluster randomized trial of endoscopic screening for esophageal cancer and gastric cancer in China. The objective of the study was to report the baseline screening findings in this trial. METHODS: We recruited a total of 345 eligible clusters from seven screening centers. In the intervention group, participants from high-risk areas were screened by endoscopy; in non-high-risk areas, high-risk individuals were identified using a questionnaire and advised for endoscopy. Lugol's iodine staining in esophagus and indigo carmine dye in stomach were performed to aid in the diagnosis of suspicious lesions. The primary outcomes of this study were the detection rate (proportion of positive cases among individuals who underwent endoscopic screening) and early detection rate (the proportion of positive cases with stage 0/I among all positive cases). RESULTS: A total of 149,956 eligible subjects were included. The detection rate was 0.7% in esophagus and 0.8% in stomach, respectively. Compared with non-high-risk areas, the detection rates in high-risk areas were higher, both in esophagus (0.9% vs. 0.1%) and in stomach (0.9% vs. 0.3%). The same difference was found for early-detection rate (esophagus: 92.9% vs. 53.3%; stomach: 81.5% vs. 33.3%). CONCLUSIONS: The diagnostic yield of both esophagus and stomach were higher in high-risk areas than in non-high-risk areas, even though in non-high-risk areas, only high-risk individuals were screened. Our study may provide important clues for evaluating and improving the effectiveness of upper-endoscopic screening in China. TRIAL REGISTRATION: Protocol Registration System in Chinese Clinical Trial Registry, ChiCTR-EOR-16008577. Registered 01 June 2016-Retrospectively registered, http://www.chictr.org.cn/showprojen.aspx?proj=14372.

8.
Beilstein J Nanotechnol ; 11: 1655-1662, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33194515

RESUMO

The tracking of body motion, such as bending or twisting, plays an important role in modern sign language translation. Here, a subtle flexible self-powered piezoelectric sensor (PES) made of graphene (GR)-doped polyvinylidene fluoride (PVDF) nanofibers is reported. The PES exhibits a high sensitivity to pressing and bending, and there is a stable correlation between bending angle and piezoelectric voltage. The sensitivity can be adjusted by changing the doping concentration of GR. Also, when the PES contacts a source of heat, a pyroelectric signal can be acquired. The positive correlation between temperature and signal can be used to avoid burns. The integrated sensing system based on multiple PESs can accurately recognize the action of each finger in real time, which can be effectively applied in sign language translation. PES-based motion-tracking applications have been effectively used, especially in human-computer interaction, such as gesture control, rehabilitation training, and auxiliary communication.

9.
Trop Med Int Health ; 2020 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-33159827

RESUMO

OBJECTIVES: To evaluate the prevalence of Helicobacter pylori infection and risk factors and to serotype the strains in Wuwei, located in northwestern China, which has a high incidence of gastric cancer. METHODS: H. pylori infection was analyzed in 21291 adults by 14 C-urea breath test, and H. pylori antibody were detected in 9183 serum samples by latex immunoturbidimetric method. The correlation of H. pylori infection with demographic-economic, lifestyle factors, and medical history among the participants was determined by questionnaire. The antibodies against H. pylori urease, VacA, and CagA in serum were determined by dot immunobinding assay. RESULTS: The infection rate of H. pylori was 53.0%, and 90.1% of strains were type I strains. The H. pylori infection rate was higher among farmers (OR=1.34, 95% CI: 1.19-1.50) and individuals who had a junior high school or higher education level (OR=1.10, 95% CI: 1.06-1.15), and was lower in older individuals (OR=0.86, 95% CI: 0.83-0.90), individuals with high income (OR=0.93, 95% CI: 0.90-0.95), individuals with a habit of eating quickly (OR=0.93, 95% CI: 0.87-0.99), and individuals who consumed more fruit and vegetabless (OR=0.90, 95% CI: 0.85-0.95). Individuals with history of cholecystitis/cholecystolithiasis, hypertension, and asthma were negatively correlated with H. pylori infection (P<0.05). CONCLUSION: The prevalence of H. pylori infection is high in Wuwei. The major prevalent strain is type I strain. Age, education, occupation, household income, consumption of fruit and vegetabless, and habit of eating quickly are independent risk factors for H. pylori infection, which is also associated with individuals with a history of extra-gastric diseases.

10.
Ann Transl Med ; 8(19): 1213, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33178745

RESUMO

Osteoarthritis (OA) is a degenerative disease of middle-aged and elderly people, contributed a higher burden of disease in China and the world. In 2017, under the support of the Rheumatology and Immunology Expert Committee of the Cross-Strait Medical and Health Exchange Association. The objective was to develop an evidence-based diagnosis and treatment guideline for OA in China based on emerging new evidence. The guideline was registered at International Practice Guidelines Registry Platform (IPGRP-2018CN028). The grading of recommendations assessment, development and evaluation (GRADE) approach was used to rate the quality of evidence and the strength of recommendations, and the RIGHT (Reporting Items for Practice Guidelines in Healthcare) checklist was followed to report the guideline. The guideline provides recommendations for the OA diagnosis, disease risks monitoring and evaluate, treatment purpose and physical, medical and surgical interventions. This guideline is intended to serve as a tool for Chinese clinicians for the best decisions-making on diagnosis and treatment of OA.

11.
Ann Transl Med ; 8(17): 1068, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33145287

RESUMO

Background: The classification criteria of osteoarthritis (OA) is lack of the support of relevant research evidence and there is no standardized protocol for detailed steps of the development or clinical verification of classification criteria has yet been established. This study aims to describe the development process of the Categorization of Osteoarthritis CHecklist (COACH), which is designed to choose the precise treatment option for patients with OA. Methods: A multidisciplinary panel was established to gather opinions. We conducted questionnaire survey and literature review to generate and COACH Panel members were invited to review the drafted classification criteria and optimize classification criteria. The final list of items was discussed and reached the agreement by the core group of the panel. Results: Thirty-six experts participated in COACH Panel including rheumatologist (80.6%; 29/36), orthopedist (13.9%; 5/36), methodologist (2.8%; 1/36) and rehabilitation physician (2.8%; 1/36) for classification factors generating and optimizing. The main body of the final classification criteria consists of six types of OA pathogenesis, eight types of medical findings (which can be grouped into two categories), and six types of the location. The final criteria include load-based type, structure-based type, inflammation-based type, metabolic-based type, systemic factor based type and mixed type. Conclusions: COACH can better help clinicians quickly classify OA patients and help to choose the best treatment option from the aspects of types, findings and locations. What's more, the classification criteria are also helpful to promote the basic medical research and targeted prevention of OA.

12.
Clin Rheumatol ; 2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-33058034

RESUMO

Rheumatoid arthritis (RA) significantly impacts the health of Chinese patients. Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) are used as the standard treatment for patients with RA. However, Chinese patients with RA have reported poor compliance with csDMARDs. This study aims to better understand the safety and compliance of using csDMARDs in RA treatment. Face-to-face interviews were conducted by questionnaires on safety and compliance of csDMARDs in 400 patients with RA and 100 rheumatologists from 13 cities in China. Rheumatologists were from Tier 3 Class A hospitals with independent rheumatology departments, who admitted more than 30 patients with RA per week. All patients were diagnosed for > 3 months before the survey and had been treated with csDMARDs for > 3 months. The incidence of adverse events (AEs) that attributed to csDMARDs estimated by rheumatologists was lower than that reported by patients for all four prescribed csDMARDs. Also, types of common AEs in rheumatologist's perception differed from those in the patient's report. Only 86% (116/135) of patients claimed they notified their rheumatologist about AEs, and 40.8% (150/368) of patients did not strictly adhere to their prescribed treatment. Reasons why patients were not compliant with their treatment, other than AEs, included symptoms being less severe, travel, and busy working life/business trips. This study revealed gaps in perceptions of csDMARDs-related AEs and medication adherence between rheumatologists and patients. These findings suggested adequate doctor-patient communications, and considerations of multiple real-world situations may improve adherence in the treatment of RA patients. Key Points • This study identified gaps in rheumatologists' perception of the prevalence and type of AEs experienced by their patients, which could potentially help them improve their patients' compliance with treatment.

13.
Front Immunol ; 11: 578732, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33123163

RESUMO

Aim: Ankylosing spondylitis (AS) primarily affects the axial skeleton and extraarticular structures. Small-scaled studies have reported that the incidence and prevalence of inflammatory bowel disease (IBD) are higher in patients with AS than in the general population. This study determined the incidence of IBD in patients with AS using a large scale population-based cohort dataset. Methods: This was a retrospective cohort study. Patient data were collected from the Taiwan National Health Insurance Research Database from 2000 to 2012. We enrolled 3,804 patients with AS and 7,608 non-AS patients. The endpoint was IBD diagnosis by using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) coding 555 and 556 after at least three outpatient visits or one hospital admission, until the end of 2012. The Kaplan-Meier analysis was performed to discriminate the cumulative incidence of IBD and the log-rank test was used to test the significance. A Cox proportional hazard model was used to estimate the hazard ratio (HR) for IBD between the AS and non-AS groups. Results: Among the population as a whole the Cox proportional hazard regression indicated that patients aged ≥65 years [adjusted HR (aHR): 2.48, 95% confidence interval (CI): 1.38-4.47] or with comorbidity of cancer (aHR: 3.51, 95% CI: 1.40-8.80) had a higher HR for IBD. Kaplan-Meier curves of cumulative incidence proportion of IBD indicated that patients with AS had a higher risk of IBD than the non-AS group in the subgroup aged <40 years (HR: 2.85, 95% CI: 1.51-5.40, p = 0.001). Conclusions: Patients with AS aged <40 years had a higher IBD risk than did those without AS in Taiwan. Clinicians and patients should be aware of this association.

14.
Front Cell Dev Biol ; 8: 798, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32974344

RESUMO

Osteoporosis is a kind of brittle bone disease, which is characterized by a reduction in bone mineral density (BMD). In recent years, a number of genes and pathophysiological mechanisms have been identified for osteoporosis. However, the genes associated with BMD remain to be explored. Toward this end, we integrated multiple osteoporosis microarray datasets to identify and systematically characterize BMD-related genes. By integrating the differentially expressed genes from three osteoporosis microarray datasets, 152 genes show differentially expressed between high and low BMD osteoporosis samples in at least two of the three datasets. Among them, 88 were up-regulated in high BMD samples and 64 were up-regulated in low BMD samples. The expression of ZFP36, JUNB and TMEM8A were increased at high BMD samples in all three datasets. Hub genes were further identified by co-expression network analysis. Functional enrichment analysis showed that the gene up-regulated in high BMD were enriched in immune-related functions, suggesting that the immune system plays an important role in osteoporosis. Our study explored BMD-related genes based on the integration of osteoporosis microarray data, providing guidance to other researchers from a new perspective.

15.
Trials ; 21(1): 795, 2020 Sep 16.
Artigo em Inglês | MEDLINE | ID: mdl-32938470

RESUMO

BACKGROUND: Osteoarthritis (OA) is a common chronic disease in older adults. Currently, there are no effective therapies to reduce disease severity and progression of knee OA (KOA), particularly in mid- to late-stages. This study aims to examine the effect of methotrexate (MTX) on knee effusion-synovitis and pain in symptomatic patients with mid- to late-stage KOA. METHODS/DESIGN: This protocol describes a multicentre randomised placebo-controlled clinical trial aiming to recruit 200 participants with mid- to late-stage symptomatic KOA and with effusion-synovitis grade of ≥ 2. Participants will be randomly allocated to the MTX group (start from 5 mg per week for the first 2 weeks and increase to 10 mg per week for the second 2 weeks and 15 mg per week for the remaining period if tolerated) or the placebo group. Primary outcomes are effusion-synovitis size measured by magnetic resonance imaging (MRI) and knee pain assessed by visual analogue scale (VAS). Secondary outcomes are signal intensity alteration within infrapatellar fat pad (IPFP) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score and subscores, and the Outcome Measures in Rheumatology Arthritis Clinical Trials-Osteoarthritis Research Society International (OMERACT-OARSI) responders. Both intention-to-treat and per-protocol analyses will be performed. DISCUSSION: If MTX intervention can relieve symptoms and reduce inflammation in patients with mid- to late-stage KOA, it has the potential for significant clinical and public health impact as this low-cost and commonly used intervention would delay the time to knee replacement, leading to substantial cost savings and improve quality of life. TRIAL REGISTRATION: ClinicalTrials.gov NCT03815448 . Registered on 21 January 2019.

16.
ACS Appl Mater Interfaces ; 12(32): 35856-35872, 2020 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-32805786

RESUMO

Cryogels with tissue adhesion have great potential as wound dressings for rapid hemostasis for uncontrollable nonpressing surface hemorrhage and wound healing, but their use has not been reported previously. Herein, we designed a series of antibacterial and antioxidant tissue-adhesive cryogels based on quaternized chitosan (QCS) and polydopamine (PDA). These cryogels had good blood cell and platelet adhesion, enrichment, and activation properties for rapid nonpressing surface hemostasis and wound healing. The cryogels exhibited outstanding mechanical strength and easy removability, antioxidant activity, and NIR photothermal-enhanced antibacterial performance. The cryogels showed much better hemostasis than gauze and gelatin sponge in a standardized strip rat liver injury model, a standardized circular rabbit liver section model, and a pig skin laceration model. Furthermore, the excellent hemostatic performance of the QCS/PDA2.0 cryogel (containing 20 mg/mL QCS and 2.0 mg/mL PDA) for coagulopathic hemorrhages was confirmed in a standardized coagulation disorder rabbit circular liver section model. In addition, the QCS/PDA2.0 cryogel promoted rapid hemostasis in a deep noncompressible wound and a much better wound healing effect than a chitosan sponge and Tegaderm film in a full-thickness skin defect model. Overall, these multifunctional tissue-adhesive cryogels with excellent hemostatic performance and enhanced wound healing properties are suitable candidates for tissue-adhesive hemostat and wound healing dressings.

17.
Eur J Cancer Care (Engl) ; 29(6): e13283, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32602238

RESUMO

OBJECTIVE: To evaluate the health-related quality of life (HRQoL) and health state utility scores of gastric cancer patients in daily life at different clinical stages after treatment, and to explore influencing factors associated with HRQoL. METHODS: Gastric cancer patients discharged from hospitals and healthy controls identified by screening were recruited. The three-level EQ-5D was employed to assess HRQoL and was scored using two Chinese-specific tariffs published in 2014 and 2018. RESULTS: A total of 1,399 patients and 2,179 healthy controls were recruited. The likelihood of reporting problems in the five dimensions for patients was 4.0-23.8 times higher than controls. Based on the 2014/2018 tariff, the mean EQ-5D utility score was 0.321/0.163 lower than controls, and the mean utility scores of each patient subgroup were 0.077/0.039 (high-grade intraepithelial neoplasia/carcinoma in situ), 0.254/0.121 (Stage I), 0.249/0.123 (Stage II), 0.353/0.182 (Stage III) and 0.591/0.309 (Stage IV) lower than controls (all statistically significant). Age, occupation, duration of illness, other chronic disease status and therapeutic regimen had a significant impact upon different aspects of HRQoL in patients. CONCLUSIONS: Gastric cancer significantly impaired patients' HRQoL in daily life after treatment. More advanced cancer stages were associated with larger decrements on health state utility.

18.
Anal Chim Acta ; 1122: 31-38, 2020 Jul 25.
Artigo em Inglês | MEDLINE | ID: mdl-32503741

RESUMO

An upright GO (UGO) modified screen-printed electrode was prepared with the help of the external magnetic field for improving its electrochemical performance. The ratio of GO: Nafion and the magnetic field intensity on the properties of UGO were examined by scanning electron microscope, cyclic voltammetry and electrochemical impedance spectroscopy. The magnetic field intensity does not influence the electron transfer kinetics but increase the number of active sites and therefore enhance the electroactive surface area. In addition, the UGO electrode that was electrodeposited Ni nanoparticles (denotes as Ni NPs/UGO modified electrode) display excellent oxidation towards glycine using chronoamperometry. The Ni NPs/UGO modified electrode indicated an excellent performance for electrochemical COD (chemical oxide demand) analysis with a linear detection range of 0.1-400 mg/L and a lower detection limit of 0.02 mg/L. Moreover, this Ni NPs/UGO modified electrode can be applied to the rapid determination of COD in general real water samples. The results were in agreement with those obtained by using the standard method (ISO 6060).

19.
Mater Sci Eng C Mater Biol Appl ; 109: 110551, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32228967

RESUMO

Accelerated osseointegration is well considered as a critical facilitated factor for titanium scaffold longevity,but immensely limited by bioinert material surfaces and restricted biological responses in vivo. Here, we fabricated three-dimensional printed porous titanium scaffold modified with titanium dioxide (TiO2) nanotubes (p-TNTs), for mimicking the hierarchical trabecular bone structure and building local drug delivery system to accelerate osseointegration. The scaffold at macro and micro gradient was manufactured by selective laser melting process with pure titanium powder according to the computer-aided design (CAD), which could be further anodized to construct nano-gradient frameworks and drug-loading districts. Sequentially, 1α,25-Dihydroxyvitamin D3 (VD3) was loaded into anodized TiO2 nanotubes,thermo-sensitive hydrogel Pluronic F-127 (F-127) was coated and charged as a bio-cap for control release. Biological responses in vitro and in vivo was evaluated, showing significant osteogenesis enhancement of hierarchical structure with local drug delivery. It suggests that a promising bioactive implant system may provide a far-reaching impact on accelerating and enhancing early osseointegration.

20.
Mol Ther Nucleic Acids ; 20: 279-291, 2020 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-32193154

RESUMO

As a common malignancy, thyroid cancer mainly occurs in the endocrine system. There have been accumulating studies on therapeutic methods of thyroid cancer, but its internal molecular mechanism is still not fully understood. Long noncoding RNA (lncRNA) OIP5-AS1 was confirmed as an oncogene and related to poor prognosis in various cancers. Nevertheless, its role and underlying mechanism remain unclear in thyroid cancer. Here, we observed a significant upregulation of OIP5-AS1 in thyroid cancer tissues and cells, and upregulated OIP5-AS1 was correlated with poor prognosis in thyroid cancer. Moreover, OIP5-AS1 knockdown resulted in the inhibited cell proliferation and migration, while overexpressed OIP5-AS1 exhibited the reverse function in thyroid cancer. Besides, OIP5-AS1 was found to positively regulate Wnt/ß-catenin signaling pathway. Through mechanism exploration, OIP5-AS1 was discovered to activate Wnt/ß-catenin signaling pathway via FXR1/YY1/CTNNB1 axis. Finally, rescue assays indicated that the inhibitive role of silenced OIP5-AS1 in thyroid cancer cell growth and Wnt/ß-catenin signaling pathway could be rescued by overexpression of CTNNB1 or addition of lithium chloride (LiCl). In conclusion, upregulation of OIP5-AS1 predicted unfavorable prognosis and enhanced thyroid cancer cell growth by activating Wnt/ß-catenin signaling pathway.

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