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1.
J Agric Food Chem ; 2021 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-33443412

RESUMO

Natural phenazines are a class of multifunctional secondary metabolites of bacteria that play an important role in the biocontrol of plant pathogens. In this paper, a novel bioactive phenazine derivative was isolated from Streptomyces lomondensis S015 through silica gel chromatography and preparative high-performance liquid chromatography (HPLC). The structure was identified as 1-carboxyl-6-formyl-4,7,9-trihydroxy-phenazine (CFTHP) by NMR spectroscopy in combination with ultraperformance liquid chromatography & mass spectrometry (UPLC-MS). CFTHP could inhibit Pythium ultimum, Rhizoctonia solani, Septoria steviae, and Fusarium oxysporum f. sp. niveum with minimal inhibitory concentration (MIC) values of 16, 32, 16, and 16 µg/mL, respectively. A global regulatory gene phoP could positively regulate CFTHP biosynthesis since its production was 3.0-fold enhanced by phoP overexpression and inhibited by phoP deletion in Streptomyces lomondensis S015. These studies illustrated the potential of CFTHP as a promising biopesticide and provided a reference for phenazine production improvement.

2.
BMC Neurol ; 21(1): 12, 2021 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-33430805

RESUMO

BACKGROUND: SPG11 mutation-related autosomal recessive hereditary spastic paraplegia with thin corpus callosum (HSP-TCC) is the most common cause in complicated forms of HSP, usually presenting comprehensive mental retardation on early-onset stage preceding spastic paraplegias in childhood. However, there are many instances of sporadic late-onset HSP-TCC cases with a negative family history, and potential mild cognitive deficits in multiple domains may be easily neglected and inaccurately described. METHODS: In this study, we performed next generation sequencing in four sporadic late-onset patients with HSP-TCC, and combined Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) to evaluate cognition of the patients. RESULTS: By evolutionary conservation and structural modeling analysis, we have revealed 4 novel pathogenic SPG11 mutations, and firstly confirmed mild cognitive impairment (MCI) with normal MMSE scores (≥27) and decreased MoCA scores (< 26) in these SPG11 mutation-related HSP-TCC patients, predominantly presenting impairment of executive function, delayed recall, abstraction and language. CONCLUSIONS: The results expand the mutational spectrum of SPG11-associated HSP-TCC from sporadic cases, and confirm MCI with combination of decreased MoCA and normal MMSE assessment, suggesting that clinicians should consider doing a MoCA to detect MCI in patients with HSP, particularly those with HSP-TCC.

3.
Hematology ; 26(1): 58-64, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33402059

RESUMO

OBJECTIVES: The remarkable effect of arsenic trioxide (ATO) was verified, but elevated gamma-glutamyltransferase (GGT), aminotransferases (ALT and AST) are generally observed in acute promyelocytic leukemia (APL) patients undergoing ATO treatment. However, utilization of hepatoprotective agents or discontinuation of ATO may inhibit ATO efficacy. In order to maintain ATO effect from hepatoprotective agents' influence so we investigate relationships between single elevation in GGT and hepatocellular injury in this study. METHODS: Correlation of GGT variation and leukocyte counts were analyzed in all 81 APL patients, correlations among liver enzymes (ALT, AST and GGT) were also analyzed in patients without prophylactic hepatoprotective agents. In following study, we take the clinical observation of changes in aminotransferases in patients with single elevation in GGT without hepatoprotective agents. RESULTS: The average elevated GGT in the WBC abnormal group was more than the normal group (53.86U/L vs. 31.03U/L, P = 0.008), a positive Pearson's correlation of GGT variation and changed leukocyte counts in patients without prophylactic hepatoprotective agents. There are no significant correlation between aminotransferases (ALT and AST) and GGT but correlation between ALT and AST was statistically significant (R = 0.649, P = 0.000). For APL patients with single elevation in GGT, ALT and AST levels were normal throughout the ATO treatment without hepatoprotective agents. CONCLUSION: Single elevation in GGT without elevated aminotransferases can't be identified as hepatotoxicity, and the elevated levels of GGT are associated with increasing leukocyte counts. Continue single-agent ATO without prophylactic hepatoprotective agents is recommended in APL patients with single elevation in GGT, in order to maintain ATO effect.

5.
Gene ; 769: 145210, 2021 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-33069807

RESUMO

Nonexpressor of pathogenesis-related (NPR) genes are bona fide transcription cofactors in the signal transduction pathway of salicylic acid (SA) and play critical regulatory roles in plant immunity. However, the NPR family genes in Brassica juncea var. tumida have not yet been comprehensively identified and analyzed as of yet. In the present study, NPR genes in B. juncea var. tumida seedlings were identified, and the tissue-specific expression patterns of NPR genes in the seedling were analyzed under salt stress (200 mM) treatment and infection by Plasmodiophora brassicae. A total of 19 NPR family genes clustering into six separate groups were identified in the genome of B. juncea var. tumida. These BjuNPR family genes were located in 11 of 18 chromosomes of B. juncea var. tumida and each possessed 1-5 exons. The BjuNPR family members had similar protein structures and conserved motifs. The BjuNPR genes exhibited tissue-specific expression patterns in the root, stem, leaf, flower and pod. Some BjuNPR genes were sensitive to salt stress and showed up-regulated or down-regulated expression patterns and most BjuNPR genes were up-regulated upon infection by P. brassicae. This study provides a foundation for further research into BjuNPR genes regulation in plant growth, development, and abiotic stress tolerance.

6.
Indian J Pediatr ; 88(2): 113-119, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32472349

RESUMO

OBJECTIVE: To study the dynamic change of peripheral lymphocyte subsets and its clinical value in children with infectious mononucleosis (IM). METHODS: Thirty-six pediatric patients with IM, 19 children with IM-like symptoms but lacking the serological pattern compatible with EB virus infection, and 33 healthy children were enrolled. The changes of peripheral lymphocyte subsets were detected by flow cytometry on admission and on the fifth day of antiviral treatment, respectively. Indicators of liver function and routine blood count were also detected. Besides, the receiver operating characteristic (ROC) curve and the correlation of related indicators was analyzed. RESULTS: When IM patients were admitted, the frequency and absolute number of T, CD4-CD8+T, and CD4+CD8+T (DPT) cells were significantly increased while B cells were decreased; the frequency of CD4+CD8-T cells were decreased, but its absolute number did not change significantly; the frequency of NK cells decreased, but its absolute number increased. The absolute number of CD4-CD8+T most significantly positively correlated with serum lactate dehydrogenase (LDH) concentration which could reflect the severity of IM patients. After short-term treatment with acyclovir, elevated lymphocytes decreased, but only DPT-cell frequency and NK-cell absolute number were recovering towards normal. The ROC curve suggested that the frequency of B cells has better diagnostic value for IM in pediatric patients compared to other lymphocyte subsets. CONCLUSIONS: Peripheral lymphocyte subsets are closely related to the condition of children with IM, and each subset plays a relatively different role in the diagnosis and evaluation of IM.

7.
Eur J Med Chem ; 209: 112868, 2021 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-33077265

RESUMO

According to the binding mode of ABBV-744 with bromodomains and the cape space of HDAC, the novel selective HDAC/BRD4 dual inhibitors were designed and synthesized by the pharmacophore fusion strategy. Evaluating the biomolecular activities through SARs exploration identified three kinds of selective dual inhibitors 41c (HDAC1/BRD4), 43a (pan-HDAC/BRD4) and 43d (HDAC6/BRD4(BD2)), whose target-related cellular activities in MV-4-11 cells were also confirmed. Significantly, the selective dual inhibitor 41c (HDAC1/BRD4) exhibited synergistic effects against MV-4-11 cells, which strongly induced G0/G1 cell cycle arrest and apoptosis, and the first HDAC6/BRD4(BD2) dual inhibitor was found. This study provides support for selective HDAC/BRD4 dual inhibitors as epigenetic probes based on pyrrolopyridone core for the future biological evaluation in different cancer cell lines.

8.
Chemosphere ; 263: 128308, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33297245

RESUMO

Soil particle size significantly affects the distribution and migration of chromium (Cr) in soil. Limited studies have investigated the impact of soil particle size on Cr partitioning at chromate contaminated sites. In this study, the physicochemical properties of coarse sand, medium sand, fine sand, and silt-clay were analyzed. And the particle size effects on partitioning, leachability, and bioaccessibility of total Cr and Cr(VI) were determined. The results showed the distribution factor (DF) of Cr(VI) in the coarse sand, medium sand, fine sand, and silt-clay fractions were 0.70, 0.79, 1.35, and 1.60, respectively. The total Cr DF values also had the similar result. The leached concentrations of total Cr and Cr(VI) in silt-clay (562.89 mg/L and 551.71 mg/L) was higher than in coarse sand (238.55 mg/L and 228.68 mg/L) fraction. The bioaccessibility of total Cr and Cr(VI) in silt-clay (77.72% and 88.58%) was higher than in fine sand (60.72% and 79.55%) fraction. The total Cr proportion of the exchangeable fraction (45.92%-73.67%) was relatively high in the four soil particle size fractions and gradually increased as soil particle size decreased. These implied that finer soil particles are more capable of enriching, mobilizing, and bioaccessibility of Cr and Cr(VI) than the coarse particles, which was related to the higher organic matter, cation exchange capacity, specific surface area, and clay components in smaller particles. The results suggested that higher environmental risk occurred in the finer fraction than in the coarser fraction for the chromate production contaminated soil.


Assuntos
Poluentes do Solo , Solo , Cromatos , Cromo/análise , Argila , Tamanho da Partícula , Poluentes do Solo/análise
9.
IEEE Trans Cybern ; PP2020 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-33259323

RESUMO

This article is concerned with the robust cooperative optimal control of nonlinear multiagent systems (MASs) with external disturbances and modeling uncertainties. Using the super-twisting algorithm, a continuous sliding-mode control protocol is presented for high-order nonlinear MASs with multiple inputs. The sliding-mode dynamics is modeled by the Takagi-Sugeno fuzzy approach, and the nominal control protocol that guarantees the robust optimization of the cost function is designed. Directed topologies are allowed using the presented protocol, and many assumptions about topologies are removed. Finally, three numerical examples are reported to demonstrate the effectiveness and improved performance of the presented protocol.

10.
Cell Prolif ; : e12971, 2020 Dec 21.
Artigo em Inglês | MEDLINE | ID: mdl-33349993

RESUMO

OBJECTIVES: The present study clarified the role and signalling pathway of Ski in regulating proliferation and apoptosis in fibroblasts under high-glucose (HG) conditions. MATERIALS AND METHODS: The proliferation and apoptosis of rat primary fibroblasts were assessed using EdU incorporation and TUNEL assays. The protein and phosphorylation levels of the corresponding factors were measured using immunofluorescence staining and Western blotting. Immunoprecipitation was used to determine the interactions between Ski and FoxO1 or Ski and HDAC1. The Ski protein was overexpressed via recombinant adenovirus transfection, and FoxO1 and HDAC1 were knocked down using targeted small-interfering RNA. RESULTS: The present study found that HG inhibited fibroblast proliferation, increased apoptosis and reduced Ski levels in rat primary fibroblasts. Conversely, increasing Ski protein levels alleviated HG-induced proliferation inhibition and apoptosis promotion. Increasing Ski protein levels also increased Ski binding to FoxO1 to decrease FoxO1 acetylation, and interfering with FoxO1 caused loss of the regulatory effect of Ski in fibroblasts under HG. Increasing Ski protein levels decreased FoxO1 acetylation via HDAC1-mediated deacetylation. CONCLUSIONS: Therefore, these findings confirmed for the first time that Ski regulated fibroblast proliferation and apoptosis under HG conditions via the FoxO1 pathway.

11.
Contrast Media Mol Imaging ; 2020: 8843084, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33299387

RESUMO

Previous studies using contrast-enhanced imaging for glioma isocitrate dehydrogenase (IDH) mutation assessment showed promising yet inconsistent results, and this study attempts to explore this problem by using an advanced tracer kinetic model, the distributed parameter model (DP). Fifty-five patients with glioma examined using dynamic contrast-enhanced imaging sequence at a 3.0 T scanner were retrospectively reviewed. The imaging data were processed using DP, yielding the following parameters: blood flow F, permeability-surface area product PS, fractional volume of interstitial space Ve, fractional volume of intravascular space Vp, and extraction ratio E. The results were compared with the Tofts model. The Wilcoxon test and boxplot were utilized for assessment of differences of model parameters between IDH-mutant and IDH-wildtype gliomas. Spearman correlation r was employed to investigate the relationship between DP and Tofts parameters. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis and quantified using the area under the ROC curve (AUC). Results showed that IDH-mutant gliomas were significantly lower in F (P = 0.018), PS (P < 0.001), Vp (P < 0.001), E (P < 0.001), and Ve (P = 0.002) than IDH-wildtype gliomas. In differentiating IDH-mutant and IDH-wildtype gliomas, Vp had the best performance (AUC = 0.92), and the AUCs of PS and E were 0.82 and 0.80, respectively. In comparison, Tofts parameters were lower in K trans (P = 0.013) and Ve (P < 0.001) for IDH-mutant gliomas. No significant difference was observed in Kep (P = 0.525). The AUCs of K trans, Ve, and Kep were 0.69, 0.79, and 0.55, respectively. Tofts-derived Ve showed a strong correlation with DP-derived Ve (r > 0.9, P < 0.001). K trans showed a weak correlation with F (r < 0.3, P > 0.16) and a very weak correlation with PS (r < 0.06, P > 0.8), both of which were not statistically significant. The findings by DP revealed a tissue environment with lower vascularity, lower vessel permeability, and lower blood flow in IDH-mutant than in IDH-wildtype gliomas, being hostile to cellular differentiation of oncogenic effects in IDH-mutated gliomas, which might help to explain the better outcomes in IDH-mutated glioma patients than in glioma patients of IDH-wildtype. The advantage of DP over Tofts in glioma DCE data analysis was demonstrated in terms of clearer elucidation of tissue microenvironment and better performance in IDH mutation assessment.

12.
Molecules ; 25(22)2020 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-33182574

RESUMO

A pyrimidine moiety exhibiting a wide range of pharmacological activities has been employed in the design of privileged structures in medicinal chemistry. To prepare libraries of novel heterocyclic compounds with potential biological activities, a series of novel 2-(pyridin-2-yl) pyrimidine derivatives were designed, synthesized and their biological activities were evaluated against immortalized rat hepatic stellate cells (HSC-T6). Fourteen compounds were found to present better anti-fibrotic activities than Pirfenidone and Bipy55'DC. Among them, compounds ethyl 6-(5-(p-tolylcarbamoyl)pyrimidin-2-yl)nicotinate (12m) and ethyl 6-(5-((3,4-difluorophenyl)carbamoyl)pyrimidin-2-yl)nicotinate (12q) show the best activities with IC50 values of 45.69 µM and 45.81 µM, respectively. Furthermore, the study of anti-fibrosis activity was evaluated by Picro-Sirius red staining, hydroxyproline assay and ELISA detection of Collagen type I alpha 1 (COL1A1) protein expression. Our study showed that compounds 12m and 12q effectively inhibited the expression of collagen, and the content of hydroxyproline in cell culture medium in vitro, indicating that compounds 12m and 12q might be developed the novel anti-fibrotic drugs.

13.
Molecules ; 25(22)2020 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-33218007

RESUMO

A series of novel synthetic substituted benzo[d]oxazole-based derivatives (5a-5v) exerted neuroprotective effects on ß-amyloid (Aß)-induced PC12 cells as a potential approach for the treatment of Alzheimer's disease (AD). In vitro studies show that most of the synthesized compounds were potent in reducing the neurotoxicity of Aß25-35-induced PC12 cells at 5 µg/mL. We found that compound 5c was non-neurotoxic at 30 µg/mL and significantly increased the viability of Aß25-35-induced PC12 cells at 1.25, 2.5 and 5 µg/mL. Western blot analysis showed that compound 5c promoted the phosphorylation of Akt and glycogen synthase kinase (GSK-3ß) and decreased the expression of nuclear factor-κB (NF-κB) in Aß25-35-induced PC12 cells. In addition, our findings demonstrated that compound 5c protected PC12 cells from Aß25-35-induced apoptosis and reduced the hyperphosphorylation of tau protein, and decreased the expression of receptor for AGE (RAGE), ß-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), inducible nitric oxide synthase (iNOS) and Bcl-2-associated X protein/B-cell lymphoma 2 (Bax/Bcl-2) via Akt/GSK-3ß/NF-κB signaling pathway. In vivo studies suggest that compound 5c shows less toxicity than donepezil in the heart and nervous system of zebrafish.

14.
Eur J Clin Pharmacol ; 2020 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-33150478

RESUMO

PURPOSE: A meta-analysis was performed to evaluate the correlation between single-nucleotide polymorphisms (SNPs) and risk of statin-induced myopathy (SIM). METHODS: We retrieved the studies published on SIM until April 2019 from the PubMed, Embase, and Cochrane Library databases. We collected data from 32 studies that analyzed 10 SNPs in five genes and included 21,692 individuals and nine statins. RESULTS: The analysis of the heterozygous (p = 0.017), homozygous (p = 0.002), dominant (p = 0.005), and recessive models (p = 0.009) of SLCO1B1 rs4149056 showed that this SNP increases the risk of SIM. Conversely, heterozygous (p = 0.048) and dominant models (p = 0.030) of SLCO1B1 rs4363657 demonstrated that this SNP is associated with a reduced risk of SIM. Moreover, an increased risk of SIM was predicted for carriers of the rs4149056 C allele among simvastatin-treated patients, whereas carriers of the GATM rs9806699 A allele among rosuvastatin-treated patients had a lower risk of SIM. CONCLUSION: The meta-analysis revealed that the rs4149056 and rs4363657 SNPs in SLCO1B1 and the rs9806699 SNP in GATM are correlated with the risk of SIM.

15.
Nanotechnology ; 2020 Nov 12.
Artigo em Inglês | MEDLINE | ID: mdl-33181503

RESUMO

Parametric amplification is widely used in nanoelectro-mechanical systems to enhance the transduced mechanical signals. Although parametric amplification has been studied in different mechanical resonator systems, the nonlinear dynamics involved receives less attention. Taking advantage of the excellent electrical and mechanical properties of graphene, we demonstrate electrical tunable parametric amplification using a doubly clamped graphene nanomechanical resonator. By applying external microwave pumping with twice the resonant frequency, we investigate parametric amplification in the nonlinear regime. We experimentally show that the extracted coefficient of the nonlinear Duffing force α and the nonlinear damping coefficient η vary as a function of external pumping power, indicating the influence of higher-order nonlinearity beyond the Duffing (~x^3) and van der Pol (~x^2 dx/dt) types in our device. Even when the higher-order nonlinearity is involved, parametric amplification still can be achieved in the nonlinear regime. The parametric gain increases and shows a tendency of saturation with increasing external pumping power. Further, the parametric gain can be electrically tuned by the gate voltage with a maximum gain of 10.2 dB achieved at the gate voltage of 19 V. Our results will benefit studies on nonlinear dynamics, especially nonlinear damping in graphene nanomechanical resonators that has been debated in the community over past decade.

16.
Biomacromolecules ; 21(12): 5256-5268, 2020 Dec 14.
Artigo em Inglês | MEDLINE | ID: mdl-33201680

RESUMO

C13-dipeptides that did not gel on their own were found to form hydrogels when combined with mixtures (coassembly). At pH = 4.6, by mixing negatively charged C13-WD (C13-WD2- and/or C13-WD-) with C13-KW or C13-YK, where the side chain of K carried positive charge, two composite hydrogels with different mechanical properties were formed. The gels exhibited various fiber structures that would account for their individual functionalities. According to molecular dynamics computer simulations, the composite systems formed spherical micelles through hydrophobic interactions that further aggregate to form gels through electrostatic interactions. The electrostatic repulsions between C13-WD molecules were interfered by insertions of C13-KW or C13-YK molecules, which result in gel formation in the composite systems. The results of computer simulations well explained the experimental observations, which provided new insights into the design and selection strategies for peptide gelators.

17.
Dalton Trans ; 49(46): 16627-16632, 2020 Dec 08.
Artigo em Inglês | MEDLINE | ID: mdl-33169744

RESUMO

We present a facile protocol for the controlled growth of highly oriented and polyoxometalate-incorporating HKUST-1 SURMOFs. Combining the spin-coating technique with alcohol-vapour induced growth, film thickness, crystallite orientation and crystal size can be precisely tuned. The SURMOFs exhibit excellent abilities in selective adsorption of cationic dyes and water oxidation.

18.
Adv Mater ; 32(52): e2005625, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33191506

RESUMO

Suspended single-hole transistors (SHTs) can also serve as nanoelectromechanical resonators, providing an ideal platform for investigating interactions between mechanical vibrations and charge carriers. Demonstrating such a device in silicon (Si) is of particular interest, due to the strong piezoresistive effect of Si and potential applications in Si-based quantum computation. Here, a suspended Si SHT also acting as a nanoelectromechanical beam resonator is demonstrated. The resonant frequency and zero-point motion of the device are ≈3 GHz and 0.2 pm, respectively, reaching the best level among similar devices demonstrated with Si-containing materials. The mechanical vibration is transduced to electrical readout by the SHT. The signal transduction mechanism is dominated by the piezoresistive effect. A giant apparent effective piezoresistive gauge factor with strong correlation to single-hole tunneling is extracted in this device. The results show the great potential of the device in interfacing charge carriers with mechanical vibrations, as well as investigating potential quantum behavior of the vibration phonon mode.

19.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 116-119, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33017944

RESUMO

Many prior studies on EEG-based emotion recognition did not consider the spatial-temporal relationships among brain regions and across time. In this paper, we propose a Regionally-Operated Domain Adversarial Network (RODAN), to learn spatial-temporal relationships that correlate between brain regions and time. Moreover, we incorporate the attention mechanism to enable cross-domain learning to capture both spatial-temporal relationships among the EEG electrodes and an adversarial mechanism to reduce the domain shift in EEG signals. To evaluate the performance of RODAN, we conduct subject-dependent, subject-independent, and subject-biased experiments on both DEAP and SEED-IV data sets, which yield encouraging results. In addition, we also discuss the biased sampling issue often observed in EEG-based emotion recognition and present an unbiased benchmark for both DEAP and SEED-IV.


Assuntos
Eletroencefalografia , Emoções , Encéfalo , Eletrodos , Aprendizagem
20.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1477-1480, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018270

RESUMO

Physiological parameters can be estimated from dynamic contrast enhanced magnetic resonance imaging (DCEMRI) data using pharmacokinetic models. This work evaluates the performance of various pharmacokinetic models through a retrospective study on cervix cancer, including two generalized kinetic models and three 2-compartment exchange models (2CXMs). In the current clinical practice, region of interest (ROI) is treated as a whole and the models are assessed by their top pharmacokinetic parameters. We explore the intervoxel relationship in the pharmacokinetic parameter maps and demonstrate that, for those insignificant parameters, texture descriptors can largely improve their discriminative power. Multi-parametric classifiers are developed to fuse the information carried by physiological parameters and the descriptors. Assessed merely by the top parameter, the DP (distributed parameter) model is the best one with an area under the ROC (receiver operating characteristic) curve (AUC) of 0.80; by combining multiple pharmacokinetic parameters, the ExTofts model is the winner with an AUC of 0.837. Finally, the classifier of the AATH (adiabatic approximation to the tissue homogeneity) model build on combined features achieves an AUC of 0.92.Clinical Relevance - Using data from 36 cervical cancer patients and 17 normal subjects, this work quantitatively compared the various pharmacokinetic models and provided recommendations for model selection in cervical cancer diagnosis.


Assuntos
Neoplasias do Colo do Útero , Meios de Contraste , Feminino , Humanos , Imagem por Ressonância Magnética , Curva ROC , Estudos Retrospectivos
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