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Org Lett ; 23(15): 5719-5723, 2021 08 06.
Artigo em Inglês | MEDLINE | ID: mdl-34286981


A rhodium(III)-catalyzed C-H allylation of (hetero)arenes by using 2-methylidenetrimethylene carbonate as an efficient allylic source has been developed for the first time. Five different directing groups including oxime, N-nitroso, purine, pyridine, and pyrimidine were compatible, delivering various branched allylarenes bearing an allylic hydroxyl group in moderate to excellent yields.

Zhonghua Liu Xing Bing Xue Za Zhi ; 31(11): 1306-10, 2010 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-21176699


To investigate the application of WSARE (What's Strange About Recent Events) algorithm in early warning on outbreaks of infectious diseases and to explore the multi-dimensional statistical methods for the detection of infectious diseases outbreak. Using WSARE algorithms based on historical data and Bayesian Network as baseline respectively, to analyze data on measles by mimicking the real-time monitoring and early warning system in Bao'an district, Shenzhen city, in 2007. WSARE algorithms were considered to be effective and timely in detecting the abnormally increase of measles among special population. WSARE algorithm could timely detect the abnormal increase of diseases among special local populations, thus having important value in the application of early warning system during the outbreak of infectious diseases.

Teorema de Bayes , Surtos de Doenças , Algoritmos , Doenças Transmissíveis/epidemiologia , Humanos , Sarampo/epidemiologia , Vigilância da População
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue ; 22(3): 142-5, 2010 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-20367902


OBJECTIVE: To evaluate the diagnostic value of procalcitonin (PCT) in ventilator-associated pneumonia (VAP). METHODS: Prospective study was performed. All adult patients who were admitted into the intensive care unit (ICU) of West China Hospital of Sichuan University between June 1st and October 1st and were clinically suspected of having developed VAP after 48 hours of mechanical ventilation were enrolled. Patients who had active infection or lung cancer at ICU admission or developed extrapulmonary infection during the study period were excluded. PCT and C-reactive protein (CRP) levels were measured and the clinical pulmonary infection score (CPIS) was calculated at study entry and on the day of VAP suspicion. RESULTS: In total, 49 suspected episodes of VAP in 31 cases were microbiologically confirmed in 23 and refuted in 26. Median PCT levels were 0.68 microg/L (interquartile range 0.28, 2.31) and 0.18 microg/L (0.06, 0.28) respectively in patients with and without VAP on the suspicion day (P<0.01). Using 0.31 microg/L as the best cutoff, PCT had 73.9% sensitivity and 80.8% specificity. The CPIS resulted in higher sensitivity (95.7%) but lower specificity (53.8%) when the cutoff of CPIS > or = 5. CRP had the lowest sensitivity and specificity (56.5%, 61.5%) when the cutoff of CRP was 109.5 mg/L. A CPIS > or = 5 combined with serum levels of PCT > or = 0.31 microg/L did not improve the sensitivity (69.6%), but resulted in 88.5% specificity. CONCLUSION: PCT had better specificity than CRP and CPIS in early diagnosis of VAP. Combined values of PCT and CPIS below the cut-off points could effectively exclude false-positive diagnosis of VAP.

Calcitonina/sangue , Pneumonia Associada à Ventilação Mecânica/diagnóstico , Precursores de Proteínas/sangue , Adulto , Idoso , Proteína C-Reativa/análise , Peptídeo Relacionado com Gene de Calcitonina , Diagnóstico Precoce , Humanos , Pessoa de Meia-Idade , Pneumonia Associada à Ventilação Mecânica/sangue , Estudos Prospectivos , Sensibilidade e Especificidade