Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 614
Filtrar
1.
Medicine (Baltimore) ; 101(47): e32094, 2022 Nov 25.
Artigo em Inglês | MEDLINE | ID: mdl-36451481

RESUMO

Prospective evidence on the association of obesity and metabolic health status and its transition over time with the risk of hyperuricemia in the Chinese population is limited. This study aims to investigate the phenotypic transition characteristics of metabolic obesity in Chinese adults and its association with hyperuricemia. Using the China Health and Retirement Longitudinal Survey (CHARLS) survey data in 2011 and 2015, 6059 adults aged ≥ 18 years were selected as the research people. The participants' general information, living habits, blood sample testing, and blood uric acid testing data during follow-up were extracted. According to body weight and metabolic health status, obesity phenotypes were divided into: metabolically normal weight group (MHNW), metabolically normal overweight/obesity group (MHOWO); metabolically abnormal normal weight group (MUNW); metabolically abnormal overweight/obese group (MUHOWO). Multiple linear regression was used to evaluate the correlation between metabolic obesity phenotype and serum uric acid level, and logistic regression model was used to analyze the association of metabolic obesity phenotype and transition with the risk of hyperuricemia. The average age of all subjects was (58.62 ±â€…8.93) years old, and 42.1% were male. The MHOWO phenotype was present in 19.2% of the general population and 48.6% of the baseline who were overweight or obese population. During the 4-year follow-up period, only 10.7% of participants with MHNW at baseline converted to MHOWO. Among MHOWO participants, 21.2% converted to MUHOWO. MHOWO also increased the risk of hyperuricemia (OR, 1.57; 95% CI 1.15-2.13; P = .004), both in obese and normal-weight individuals, even when metabolic status changed from unhealthy to healthy. Risk of hyperuricemia was high among those who remained metabolically unhealthy but of normal weight (OR, 3.09; 95% CI 1.51-6.30; P = .001). MHOWO also increases the risk of hyperuricemia, and MHOWO remains stable or changes to MUHOWO, which increases the risk of hyperuricemia. Therefore, close attention should be paid to the transition of metabolic health status over time, and individualized prevention strategies should be focused on metabolically unhealthy and obese individuals.


Assuntos
Hiperuricemia , Humanos , Masculino , Feminino , Hiperuricemia/complicações , Hiperuricemia/epidemiologia , Estudos de Coortes , Sobrepeso/complicações , Sobrepeso/epidemiologia , Ácido Úrico , Estudos Prospectivos , Obesidade/complicações , Obesidade/epidemiologia , Fenótipo
2.
Zhongguo Zhong Yao Za Zhi ; 47(19): 5306-5315, 2022 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-36472038

RESUMO

Based on Janus kinase 1/2-signal transducer and activator of transcription 1(JAK1/2-STAT1) signaling pathway, this study explored the immune mechanism of Maxing Shigan Decoction in alleviating the lung tissue and colon tissue damage in mice infected with influenza virus. The influenza virus infection was induced in mice by nasal drip of influenza virus. The normal group, model group, oseltamivir group, antiviral granule group, and Maxing Shigan Decoction group were designed. After intragastric administration of corresponding drugs or normal saline for 3 or 7 days, the body mass was measured, and lung index, spleen index, and thymus index were calculated. Based on hematoxylin-eosin(HE) staining, the pathological changes of lung tissue and colon tissue were observed. Enzyme-linked immunosorbent assay(ELISA) was used to detect serum levels of inflammatory factors interleukin-8(IL-8) and interferon-γ(IFN-γ), Western blot and real-time quantitative polymerase chain reaction(RT-qPCR) to determine the protein and mRNA levels of JAK1, JAK2, STAT1, interferon regulatory factor 9(IRF9), and IFN-γ in lung tissue and colon tissue. The results showed that after 3 and 7 days of administration, the body mass, spleen index, and thymus index were lower(P<0.05 or P<0.01), and the lung index was higher(P<0.01) in the model group than in the normal group. Moreover, the model group showed congestion, edema, and infiltration of a large number of lymphocytes and macrophages in the lung tissue, irregular structure of colon mucosa, ulceration and shedding of epithelial cells, and infiltration of a large number of inflammatory cells. The model group had higher levels of serum IFN-γ(P<0.01), higher protein and mRNA expression of JAK1, JAK2, STAT1, IRF9, IFN-γ in lung tissue(P<0.05 or P<0.01), higher level of JAK2 protein in colon tissue(P<0.01), and higher protein and mRNA levels of STAT1 and IRF9(P<0.05 or P<0.01) than the normal group. Compared with the model group, Maxing Shigan Decoction group had high body mass, spleen index, and thymus index(P<0.05 or P<0.01), low lung index(P<0.05 or P<0.01), and significant alleviation of pathological injury in lung and colon. Moreover, lower serum level of IFN-γ(P<0.05 or P<0.01), protein and mRNA levels of JAK1, JAK2, STAT1, IRF9, and IFN-γ in lung tissue(P<0.05 or P<0.01), JAK2 protein level in colon tissue(P<0.01), and protein and mRNA levels of STAT1 and IRF9(P<0.05 or P<0.01) were observed in the Maxing Shigan Decoction group than in the model group. After 3 days of administration, the level of serum IL-8 in the model group was significantly higher than that in the normal group(P<0.01), and the level in the Maxing Shigan Decoction group was significantly reduced(P<0.01). In conclusion, Maxing Shigan Decoction can significantly up-regulate body mass, spleen index, and thymus index, down-regulate lung index, reduce the levels of IL-8 and IFN-γ, and down-regulate protein and mRNA levels of JAK1, JAK2, STAT1, IRF9, and IFN-γ in lung tissue and protein and mRNA levels of JAK2, STAT1, and IRF9 in colon tissue, and alleviate pathological damage of lung tissue and colon tissue. The mechanism is the likelihood that it inhibits the activation of JAK1/2-STAT1 signaling pathway to alleviate the damage to lung and colon tissue damage.


Assuntos
Influenza Humana , Infecções por Orthomyxoviridae , Orthomyxoviridae , Camundongos , Animais , Humanos , Janus Quinase 1/genética , Fator de Transcrição STAT1/genética , Interleucina-8 , Transdução de Sinais , Interferon gama , Pulmão , RNA Mensageiro , Colo
3.
Artigo em Inglês | MEDLINE | ID: mdl-36472394

RESUMO

The availability of an appropriate and reliable research model is helpful for researchers to understand the occurrence and development of diseases. Historically, animal models have been beneficial in the study of intervertebral disc degenerative diseases, but intervertebral disc degeneration (IDD) is a precise and complex process that needs to appear and occur in a specific tissue microenvironment, and animal degeneration models cannot fully simulate these parameters. These challenges must be overcome, especially when animal models cannot fully generalize the complex pathology of humans. In the past few years, the research on the cell disease model has made important progress, and the construction of the nucleus pulposus cell (NPC) degeneration model has become an indispensable step in studying the occurrence and development of IDD. Here, several different methods of constructing NPC degeneration models and indicators for testing the effect of modeling are introduced. The practical applications of cell models constructed by different methods are enumerated to screen and evaluate effective methods of establishing degenerative cell models and explore the mechanism of IDD.

5.
Biomed Pharmacother ; 157: 114052, 2022 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-36462313

RESUMO

A major challenge in the field of diabetic wound healing is to confirm the body's intrinsic mechanism that could sense the immune system damage promptly and protect the wound from non-healing. Accumulating literature indicates that macrophage, a contributor to prolonged inflammation occurring at the wound site, might play such a role in hindering wound healing. Likewise, other immune cell dysfunctions, such as persistent neutrophils and T cell infection, may also lead to persistent oxidative stress and inflammatory reaction during diabetic wound healing. In this article, we discuss recent advances in the immune cellular components in wounds under the diabetic milieu, and the role of key signaling mechanisms that compromise the function of immune cells leading to persistent wound non-healing.

6.
PLoS Genet ; 18(12): e1010523, 2022 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-36469526

RESUMO

Activin and inhibin are both dimeric proteins sharing the same ß subunits that belong to the TGF-ß superfamily. They are well known for stimulating and inhibiting pituitary FSH secretion, respectively, in mammals. In addition, activin also acts as a mesoderm-inducing factor in frogs. However, their functions in development and reproduction of other species are poorly defined. In this study, we disrupted all three activin/inhibin ß subunits (ßAa, inhbaa; ßAb, inhbab; and ßB, inhbb) in zebrafish using CRISPR/Cas9. The loss of ßAa/b but not ßB led to a high mortality rate in the post-hatching stage. Surprisingly, the expression of fshb but not lhb in the pituitary increased in the female ßA mutant together with aromatase (cyp19a1a) in the ovary. The single mutant of ßAa/b showed normal folliculogenesis in young females; however, their double mutant (inhbaa-/-;inhbab-/-) showed delayed follicle activation, granulosa cell hypertrophy, stromal cell accumulation and tissue fibrosis. The ovary of inhbaa-/- deteriorated progressively after 180 dpf with reduced fecundity and the folliculogenesis ceased completely around 540 dpf. In addition, tumor- or cyst-like tissues started to appear in the inhbaa-/- ovary after about one year. In contrast to females, activin ßAa/b mutant males showed normal spermatogenesis and fertility. As for activin ßB subunit, the inhbb-/- mutant exhibited normal folliculogenesis, spermatogenesis and fertility in both sexes; however, the fecundity of mutant females decreased dramatically at 270 dpf with accumulation of early follicles. In summary, the activin-inhibin system plays an indispensable role in fish reproduction, in particular folliculogenesis and ovarian homeostasis.

7.
Microbiol Spectr ; : e0332822, 2022 Dec 08.
Artigo em Inglês | MEDLINE | ID: mdl-36475839

RESUMO

With the development and reduced costs of high-throughput sequencing technology, environmental dark matter, such as novel metagenome-assembled genomes (MAGs) and viruses, is now being discovered easily. However, due to read length limitations, MAGs and viromes often suffer from genome discontinuity and deficiencies in key functional elements. Here, by applying long-read sequencing technology to sediment samples from a Tibetan saline lake, we comprehensively analyzed the performance of high-fidelity (HiFi) reads and the possibility of integration with short-read next-generation sequencing (NGS) data. In total, 207 full-length nonredundant 16S rRNA gene sequences and 19 full-length nonredundant 18S rRNA genes were directly obtained from HiFi reads, which greatly surpassed the retrieval performance of NGS technology. We carried out a cross-sectional comparison among multiple assembly strategies, referred to as 'NGS', 'Hybrid (NGS+HiFi)', and 'HiFi'. Two MAGs and 29 viruses with circular genomes were reconstructed using HiFi reads alone, indicating the great power of the 'HiFi' approach to assemble high-quality microbial genomes. Among the 3 strategies, the 'Hybrid' approach produced the highest number of medium/high-quality MAGs and viral genomes, while the ratio of MAGs containing 16S rRNA genes was significantly improved in the 'HiFi' assembly results. Overall, our study provides a practical metagenomic resolution for analyzing complex environmental samples by taking advantage of both the short-read and HiFi long-read sequencing methods to extract the maximum amount of information, including data on prokaryotes, eukaryotes, and viruses, via the 'Hybrid' approach. IMPORTANCE To expand the understanding of microbial dark matter in the environment, we did the first comparative evaluation of multiple assembly strategies based on high-throughput short-read and HiFi data from lake sediments metagenomic sequencing. The results demonstrated great improvement of the 'Hybrid' assembly method (short-read next-generation sequencing data plus HiFi data) in the recovery of medium/high-quality MAGs and viral genomes. Further analysis showed that HiFi data is important to retrieve the complete circular prokaryotic and viral genomes. Meanwhile, hundreds of full-length 16S/18S rRNA genes were assembled directly from HiFi data, which facilitated the species composition studies of complex environmental samples, especially for understanding micro-eukaryotes. Therefore, the application of the latest HiFi long-read sequencing could greatly improve the metagenomic assembly integrity and promote environmental microbiome research.

8.
Sci Bull (Beijing) ; 67(4): 427-436, 2022 02 26.
Artigo em Inglês | MEDLINE | ID: mdl-36546094

RESUMO

One of the Holocene abrupt events around 4200 years ago, lasting for âˆ¼ 200 years, is thought to have caused cultural disruptions, yet terrestrial climatic status right after the cold/dry event remains poorly defined and is often presumed that a generally cool condition prevailed during the Bronze Age (∼ 4000-2200 years ago). Here we report an alkenone-based summer temperature record over the past âˆ¼ 12,000 years, in addition to two updated alkenone records, from Northwest China, providing new insights into the climatic status right after the event. Our results indicate that exceptional terrestrial warmth, up to âˆ¼ 6 °C, occurred around 4200-2800 years ago during the Bronze Age, superimposed on the long-term Holocene cooling trend. The exceptional warmth in Northwest China, together with other climate anomalies elsewhere, suggests an unusual large-scale climatic reorganization at 4200-2800 years ago when solar activity remained high, with important implications to the climate background for cultural developments during the Bronze Age.


Assuntos
Temperatura Baixa , Estações do Ano , China
9.
AoB Plants ; 14(6): plac054, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36518220

RESUMO

Plant leaf morphological and photosynthetic physiological characteristics are key functional traits in the adaptability of plants to heterogeneous environments. Analysis of the correlation between leaf morphological traits and photosynthetic physiological characteristics of salt marsh plants is helpful to deepen our understanding of how salt marsh plants adjust their leaf structure and function to adapt to their environment. However, there have been few studies on the relationship between leaf morphology and photosynthetic physiological characteristics of plants in inland salt marshes under a habitat gradient. A Phragmites australis community was divided into three plots based on differences in the wetland habitat conditions: a remote water area (plot I, 400-550 m from the water margin), a middle water area (plot II, 200-350 m from the water margin) and a near water area (plot III, 0-150 m from the water margin). The relationship between leaf morphological traits and photosynthetic physiological parameters of P. australis in heterogeneous habitats was studied. The results showed that as the habitat conditions changed from plot I to plot III, the soil characteristics, above-ground characteristics of the community and the photosynthetically active radiation changed significantly (P < 0.05). Besides, there was a highly significant positive correlation (P < 0.01) between leaf dry weight (LDW) and net photosynthetic rate (P n), the effective quantum yield of PSII photochemistry (Y(II), actual photochemical efficiency of PSII) and photochemical quenching (QP); and between leaf area and P n, Y(II) and QP in the three habitats. Moreover, in plot I, P. australis tended to have small and thick leaves with a low LDW and specific leaf area. In plot III, leaves were large and thin to adapt to the change in habitat conditions. This study provides a scientific theoretical basis for understanding the ecological adaptation strategies of plants in the harsh environment of an inland salt marsh and the conservation and management of wetland plants.

11.
Org Lett ; 24(50): 9301-9305, 2022 Dec 23.
Artigo em Inglês | MEDLINE | ID: mdl-36516238

RESUMO

A new class of Michael acceptor, tetrazolyl-trifluoromethyl alkenes, has been discovered. They readily undergo Michael-type addition instead of addition-elimination reaction with aliphatic amines and azoles to furnish ß-trifluoromethyl alkylamines and CF3-substituted 1,2-bisazole derivatives, respectively. Additionally, some of the products are capable of engaging in microwave-assisted intramolecular denitrogenative annulation, leading to the formation of CF3-substituted 1,4,5,6-tetrahydro-1,2,4-triazines that are otherwise difficult to access by other methodologies.

12.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ; 36(11): 869-871;874, 2022 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-36347582

RESUMO

Objective:To evaluate the effect of body mass index (BMI) on efficacy of the repositioning procedure for horizontal canal benign paroxysmal positional vertigo (HC-BPPV). Methods:A total of 172 patients diagnosed with HC-BPPV in the First Affiliated Hospital of Xi'an Jiaotong University School of Medicine from Jan 2021 to Oct 2021 were enrolled. The patients were divided into low BMI group(BMI<24 kg/m² ) and high BMI group(BMI≥24 kg/m²ï¼‰. The two groups underwent manual repositioning procedure and vertigo treatment system procedure by Barbecue method according to their orders of visits. After two circles of repositioning, the influencing factors of repositioning were analyzed according to efficiency. Results:The effective rate of manual repositioning in HC-BPPV patients was 33.64%, and the effective rate of vertigo treatment system was 63.08%,the effective rate of vertigo treatment system repositioning was higher than that of manual repositioning (P<0.05). The effective rate of manual repositioning in the low BMI group (58.70%) was higher than that in the high BMI group (14.75%), P<0.05. The effective rate of vertigo treatment system repositioning was higher in the low BMI group (75.00%) than that in the high BMI group (54.05%), but there was no statistically significant difference between the two BMI groups (P>0.05). Logistic regression analysis suggested that BMI was the influencing factor of HC-BPPV repositioning efficacy (P<0.05). Conclusion:BMI can affect the efficacy of HC-BPPV manual repositioning. Vertigo treatment system for HC-BPPV reduction is better than manual reduction, and the efficacy is not affected by BMI.


Assuntos
Vertigem Posicional Paroxística Benigna , Posicionamento do Paciente , Humanos , Vertigem Posicional Paroxística Benigna/terapia , Índice de Massa Corporal , Posicionamento do Paciente/métodos , Canais Semicirculares
13.
Protein Expr Purif ; 203: 106208, 2022 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-36403706

RESUMO

The main protease (Mpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a vital role in viral replication. To study the function of Mpro and screen inhibitors targeting Mpro, it is necessary to prepare high-purity and high-activity Mpro. In this study, four types of SARS-CoV-2 Mpros containing different termini were prepared, and their activities were determined successfully. The results showed that the activity of wild-type (WT) Mpro was the highest, and the additional residues at the N-terminus but not at the C-terminus had a major effect on the enzyme activity. To explain this, the alignment of structures of different forms of Mpro was determined, and the additional residues at the N-terminus were found to interfere with the formation of the substrate binding pocket. This study confirms the importance of the natural N-terminus to the activity of Mpro and suggests that WT-GPH6 (Mpro with eight additional residues at the C-terminus) can be used as a substitute for authentic Mpro to screen inhibitors. In short, this study provides a reference for the expression and purification of new coronaviruses confronted in the future.

14.
Yi Chuan ; 44(9): 810-818, 2022 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-36384957

RESUMO

Congenital hyperinsulinemia (CHI) is a disease phenotype characterized by persistent or recurrent hypoglycemia due to abnormal secretion of insulin by ß cells of the pancreas. CHI induced by activation mutation of a single allele of glucokinase (GCK) is the rarest type. In this paper, the clinical data of a patient with hypoglycemia of unknown cause were collected without obvious clinical symptoms. And a heterozygous missense mutation (c.295T> C:p.W99R) was detected in exon 3 of the GCK gene. The mutation was found in both the son and daughter of the proband, and the blood glucose level was low, while the others were normal. By summarizing and analyzing the characteristics of this case and the genetic pedigree of the family, the possibility of congenital hyperinsulinemia caused by a single gene mutation should be considered for hypoglycemia whose etiology is difficult to be determined clinically. This case also provides new clinical data for subsequent genetic studies of the disease.


Assuntos
Hiperinsulinismo , Hipoglicemia , Humanos , Glucoquinase/genética , Hipoglicemia/genética , Mutação , Testes Genéticos , Hiperinsulinismo/genética
15.
ACS Infect Dis ; 2022 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-36379019

RESUMO

Cyclic diguanylate (c-di-GMP) is a major bacterial secondary signaling molecule that controls a multitude of cellular processes. More than 40 genes encoding diguanylate cyclases and phosphodiesterases have been identified in Pseudomonas aeruginosa, and many of them have been intensively investigated. However, the mechanism through which they achieve signaling specificity remains unclear. Here, we revealed that the absence of the dual GGDEF/EAL-domain protein RmcA significantly affected biofilm formation of P. aeruginosa PAO1 and led to upregulated expression of the type III secretion system (T3SS) genes; overexpression of RmcA strongly reduced the expression of T3SS. Further investigation showed that the regulatory function of RmcA was independent of the Gac/Rsm pathway. To identify the interaction partners of RmcA involved in this process, bacterial two-hybrid library screening was performed. We found that RmcA directly interacts with a two-component response regulator CbrB, which is involved in the regulation of biofilm formation and T3SS expression by RmcA. These findings reveal that the dual-domain GGDEF/EAL protein RmcA could achieve specificity of action through physical interaction with CbrB, which extends understanding the complex regulatory network of the c-di-GMP signaling.

16.
Front Psychiatry ; 13: 1014952, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36339882

RESUMO

Objective: The pathogenesis of schizophrenia is associated with neuropeptide Y (NPY) gene polymorphism to explore the relationship between rs16141, rs16145, and rs5573 polymorphisms in the NPY gene and antipsychotics response in the Chinese population. Methods: The unrelated 228 Chinese Han patients with schizophrenia were enrolled in the present study. Genotypisation within NPY gene was performed using the KASP genotyping assays. Before treatment and on the weekends of the 2nd, 4th, and 8th weeks after treatment, the medication status of the patients was recorded and the positive and negative syndrome scale (PANSS) was used to evaluate the clinical effect. A reduction in total PANSS scores ≥50% were classified as good responders, while others were poor responders. We evaluated the association between NPY gene and antipsychotic efficacy by comparing allele and genotype distribution, correlation analysis, linkage imbalance, and five genetic models between the two groups. Results: No significant associations were found in the rs16141, rs16145, and rs5573 of NPY and antipsychotic treatment response (all p > 0.05). There was no significant relationship between the three SNPs polymorphisms in the NPY gene and the changes of positive, negative and general psychopathology subscales scores at each stage (all p > 0.05). The distribution of genotype and allele frequencies of locus rs16141 was not statistically difference between good responders and poor responders (genotype: χ2 =4.088, p=0.043, p-correction = 0.129; allele: χ2 = 4.088, p = 0.027, p-correction = 0.081). The allele distribution of rs5573 was significantly different between groups, yet the difference was disappeared after correcting (χ2 = 4.136, p = 0.042, p-correction =0.126). The distribution frequencies of TA/TG and GG haplotypes constituted by rs16141 and rs5573 showed no statistical difference between the two groups (p > 0.05). In recessive inheritance mode, NPYrs5573 was found to be associated with antipsychotic drug response (G/G vs. A/A +A/G: p = 0.028, AIC = 197.2, BIC = 210.9). Conclusions: This study didn't found association between polymorphisms in the NPY gene locus (rs16141, rs16145, and rs5573) and the response to antipsychotics after Bonferroni correction. The polymorphism of NPY gene and the efficacy of antipsychotic drugs in patients with schizophrenia need further study.

17.
Animals (Basel) ; 12(21)2022 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-36359059

RESUMO

African swine fever (ASF), caused by African swine fever virus (ASFV), is a highly contagious and fatal disease found in swine. However, the viral proteins and mechanisms responsible for immune evasion are poorly understood, which has severely hindered the development of vaccines. This review mainly focuses on studies involving the innate antiviral immune response of the host and summarizes the latest studies on ASFV genes involved in interferon (IFN) signaling and inflammatory responses. We analyzed the effects of candidate viral proteins on ASFV infection, replication and pathogenicity and identified potential molecular targets for novel ASFV vaccines. These efforts will contribute to the construction of novel vaccines and wonder therapeutics for ASF.

18.
Foods ; 11(21)2022 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-36360124

RESUMO

In order to solve a series of problems with kelp drying including long drying time, high energy consumption, low drying efficiency, and poor quality of dried kelp, this work proposes the design of a novel greenhouse double-evaporator solar-assisted heat pump drying system. Experiments on kelp solar-assisted heat pump drying (S-HP) and heat pump drying (HP) under the condition of irradiance of 100-700 W/m2 and a temperature of 30, 40, or 50 °C were conducted and their results were compared in terms of system performance, drying kinetics, and quality impact. The drying time was reduced with increasing irradiance or temperature. The coefficient of performance (COP) and specific moisture extraction rate (SMER) of S-HP were 3.590-6.810, and 1.660-3.725 kg/kW·h, respectively, roughly double those of HP when the temperatures are identical. The Deff of S-HP and HP were 5.431 × 10-11~11.316 × 10-11 m2/s, and 1.037 × 10-11~1.432 × 10-11 m2/s, respectively; additionally, solar radiation greatly improves Deff. The Page model almost perfectly described the changes in the moisture ratio of kelp by S-HP and HP with an inaccuracy of less than 5%. When the temperature was 40 °C and the irradiance was above 400 W/m2, the drying time of S-HP was only 3 h, and the dried kelp maintained the green color with a strong flavor and richness in mannitol. Meanwhile, the coefficient of performance was 6.810, the specific moisture extraction rate was 3.725 kg/kWh, and the energy consumption was 45.2%, lower than that of HP. It can be concluded that S-HP is highly efficient and energy-saving for macroalgae drying and can serve as an alternate technique for the drying of other aquatic products.

19.
Opt Express ; 30(23): 42347-42361, 2022 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-36366690

RESUMO

In this paper, we employ the atomic arrays in one-dimensional optical waveguides to simulate topological phases, where the waveguide is modeled as a one-dimensional infinitely long coupled cavity array. Under the Markov approximation, the coherent and dissipative coupling between atoms is established by eliminating waveguide modes. When the detuning between atoms and cavity fields lies in the band gap, the dynamics of the system is completely dominated by the coherent interaction. Under this condition, we designed three atomic arrays with different geometries and show that the topologically trivial and non-trivial phases of atomic arrays can be simulated. Furthermore, by introducing periodic atomic driving, the topological phase transition can be induced by adjusting the driving parameters. Finally, we investigate the effect of next-nearest neighbor interactions on topological state transfer and find that the next-nearest neighbor interactions break the degenerated bandgap state and establish a topological state transfer channel.

20.
Stem Cell Res Ther ; 13(1): 511, 2022 11 04.
Artigo em Inglês | MEDLINE | ID: mdl-36333820

RESUMO

Bone injury plagues millions of patients worldwide every year, and it demands a heavy portion of expense from the public medical insurance system. At present, orthopedists think that autologous bone transplantation is the gold standard for treating large-scale bone defects. However, this method has significant limitations, which means that parts of patients cannot obtain a satisfactory prognosis. Therefore, a basic study on new therapeutic methods is urgently needed. The in-depth research on crosstalk between macrophages (Mϕs) and bone marrow mesenchymal stem cells (BMSCs) suggests that there is a close relationship between inflammation and regeneration. The in-depth understanding of the crosstalk between Mϕs and BMSCs is helpful to amplify the efficacy of stem cell-based treatment for bone injury. Only in the suitable inflammatory microenvironment can the damaged tissues containing stem cells obtain satisfactory healing outcomes. The excessive tissue inflammation and lack of stem cells make the transplantation of biomaterials necessary. We can expect that the crosstalk between Mϕs and BMSCs and biomaterials will become the mainstream to explore new methods for bone injury in the future. This review mainly summarizes the research on the crosstalk between Mϕs and BMSCs and also briefly describes the effects of biomaterials and aging on cell transplantation therapy.


Assuntos
Doenças Ósseas , Transplante de Células-Tronco Mesenquimais , Células-Tronco Mesenquimais , Humanos , Transplante de Células-Tronco Mesenquimais/métodos , Células da Medula Óssea , Macrófagos , Materiais Biocompatíveis/farmacologia , Inflamação
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...