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1.
Artigo em Inglês | MEDLINE | ID: mdl-34534085

RESUMO

With the ongoing popularization of online services, the digital document images have been used in various applications. Meanwhile, there have emerged some deep learning-based text editing algorithms which alter the textual information of an image in an end-to-end fashion. In this work, we present a low-cost document forgery algorithm by the existing deep learning-based technologies to edit practical document images. To achieve this goal, the limitations of existing text editing algorithms towards complicated characters and complex background are addressed by a set of network design strategies. First, the unnecessary confusion in the supervision data is avoided by disentangling the textual and background information in the source images. Second, to capture the structure of some complicated components, the text skeleton is provided as auxiliary information and the continuity in texture is considered explicitly in the loss function. Third, the forgery traces induced by the text editing operation are mitigated by some post-processing operations which consider the distortions from the print-and-scan channel. Quantitative comparisons of the proposed method and the exiting approach have shown the advantages of our design by reducing the about 2/3 reconstruction error measured in MSE, improving reconstruction quality measured in PSNR and in SSIM by 4 dB and 0.21, respectively. Qualitative experiments have confirmed that the reconstruction results of the proposed method are visually better than the existing approach in both complicated characters and complex texture. More importantly, we have demonstrated the performance of the proposed document forgery algorithm under a practical scenario where an attacker is able to alter the textual information in an identity document using only one sample in the target domain. The forged-and-recaptured samples created by the proposed text editing attack and recapturing operation have successfully fooled some existing document authentication systems.

2.
Neurol India ; 69(4): 867-873, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34507403

RESUMO

Objective: The present study is to investigate the pre- and post-operative magnetic resonance imaging of pituitary tissues following transsphenoidal resection of pituitary macroadenomas, as well as its clinical significance. Materials and Methods: The medical records of 108 consecutive pituitary macroadenoma patients admitted at Fuzhou 900th Hospital between September 2012 and September 2014 were retrospectively reviewed. Siemens 3. 0T magnetic resonance scanner was used to perform pre- and postoperative MRI scanning, including plain scan and contrast-enhanced scan of SE sequential T1WI and T2WI in sagittal, coronal and axial views. PACS medical imaging system was used to measure the diameter of pituitary adenoma, as well as the volumes of the adenoma and pituitary tissue. Hematoxylin-eosin staining and immunohistochemical staining were also performed. Results: Higher height of pituitary adenoma results in lower rate of posterior pituitary bright spot (PPBS) on MR T1-weighted imaging. Preoperative MR signal intensity of PPBS was negatively related to diabetes insipidus (DI). Normal pituitary tissues were likely to be above the pituitary adenomas in growth hormone-secreting adenoma patients, while mostly located aside in gonadotropin-secreting adenoma patients. Morphological restitution of postoperative pituitary tissues was better in lateral displacement than that in superior or superolateral patterns on pre-operative MR images. Positive rate of PPBS on preoperative MRI is negatively related to adenoma height, and the signal intensity of PPBS is inversely related to postoperative DI. Conclusions: The relative locations of pituitary tissues and adenoma tissues may be associated with the adenoma type and may affect the postoperative remodeling of residual pituitary tissues.


Assuntos
Adenoma , Doenças da Hipófise , Neoplasias Hipofisárias , Adenoma/diagnóstico por imagem , Adenoma/cirurgia , Humanos , Imageamento por Ressonância Magnética , Neoplasias Hipofisárias/diagnóstico por imagem , Neoplasias Hipofisárias/cirurgia , Estudos Retrospectivos
3.
Interv Neuroradiol ; : 15910199211030769, 2021 Sep 13.
Artigo em Inglês | MEDLINE | ID: mdl-34516327

RESUMO

BACKGROUND: The benefit of endovascular thrombectomy for patients with in-hospital stroke remains unclear. Thus, the aim of this study was to compare the endovascular thrombectomy outcomes between in-hospital stroke and community-onset stroke among patients with acute ischemic stroke. METHODS: From January 2015 to July 2019, 362 consecutive patients with acute ischemic stroke with large vessel occlusion in the anterior circulation received endovascular thrombectomy in our centre. After propensity score matching with a ratio of 1:2 (in-hospital stroke:community-onset stroke), clinical characteristics and functional outcomes were compared between in-hospital stroke and community-onset stroke groups. RESULTS: Thirty-six patients with in-hospital stroke and 72 patients with community-onset stroke were enrolled. The number of patients with New York Heart Association classification III/IV (41.7% vs. 6.9%, p < 0.001) and with underlying cancer (25.0% vs. 2.8%, p < 0.001) was higher in the in-hospital stroke than in the community-onset stroke group. The intravenous thrombolysis rate was lower in the in-hospital stroke group (13.9% vs. 43.1%, p = 0.002). No significant difference in symptom onset to puncture (p = 0.618), symptom onset to recanalisation (p = 0.618) or good reperfusion (modified thrombolysis in cerebral infarction ≥2b) rates (p = 0.852) was found between the groups. The favourable clinical outcome trend (modified Rankin scale ≤2 at 90 days) was inferior, but acceptable, in the in-hospital stroke, group compared to the community-onset stroke group (30.6% vs. 41.7%, p = 0.262). CONCLUSION: Patients with in-hospital stroke had more disadvantageous comorbidities than those with community-onset stroke. Cardiac dysfunction seems to be associated with poor outcomes after thrombectomy. Nevertheless, endovascular thrombectomy still appears to be safe and effective for patients with in-hospital stroke.

4.
Math Biosci Eng ; 18(5): 6012-6033, 2021 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-34517521

RESUMO

In this paper, we focus on spreading speed of a reaction-diffusion SI epidemic model with vertical transmission, which is a non-monotone system. More specifically, we prove that the solution of the system converges to the disease-free equilibrium as $ t \rightarrow \infty $ if $ R_{0} \leqslant 1 $ and if $ R_0 > 1 $, there exists a critical speed $ c^\diamond > 0 $ such that if $ \|x\| = ct $ with $ c \in (0, c^\diamond) $, the disease is persistent and if $ \|x\| \geqslant ct $ with $ c > c^\diamond $, the infection dies out. Finally, we illustrate the asymptotic behaviour of the solution of the system via numerical simulations.

5.
BMJ Open ; 11(9): e047227, 2021 09 07.
Artigo em Inglês | MEDLINE | ID: mdl-34493510

RESUMO

OBJECTIVE: To evaluate epidemiological characteristics and transmission dynamics of COVID-19 outbreak resurged in Beijing and to assess the effects of three non-pharmaceutical interventions. DESIGN: Descriptive and modelling study based on surveillance data of COVID-19 in Beijing. SETTING: Outbreak in Beijing. PARTICIPANTS: The database included 335 confirmed cases of COVID-19. METHODS: To conduct spatiotemporal analyses of the outbreak, we collected individual records on laboratory-confirmed cases of COVID-19 from 11 June 2020 to 5 July 2020 in Beijing, and visitor flow and products transportation data of Xinfadi Wholesale Market. We also built a modified susceptible-exposed-infected-removed model to investigate the effect of interventions deployed in Beijing. RESULTS: We found that the staff working in the market (52.2%) and the people around 10 km to this epicentre (72.5%) were most affected, and the population mobility entering-exiting Xinfadi Wholesale Market significantly contributed to the spread of COVID-19 (p=0.021), but goods flow of the market had little impact on the virus spread (p=0.184). The prompt identification of Xinfadi Wholesale Market as the infection source could have avoided a total of 25 708 (95% CI 13 657 to 40 625) cases if unnoticed transmission lasted for a month. Based on the model, we found that active screening on targeted population by nucleic acid testing alone had the most significant effect. CONCLUSIONS: The non-pharmaceutical interventions deployed in Beijing, including localised lockdown, close-contact tracing and community-based testing, were proved to be effective enough to contain the outbreak. Beijing has achieved an optimal balance between epidemic containment and economic protection.


Assuntos
COVID-19 , Pequim/epidemiologia , China/epidemiologia , Controle de Doenças Transmissíveis , Surtos de Doenças , Humanos , SARS-CoV-2
6.
Ann Palliat Med ; 10(8): 9223-9228, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34488408

RESUMO

BACKGROUND: The optimal duration of treatment for intestinal tuberculosis (TB), which remains a common disease worldwide, has not yet been established. The proposed randomized controlled study will aim to compare the efficacy of short-term six-month with nine-month anti-TB therapy for treating intestinal TB. METHODS: This multicenter, open-label, double-blinded, randomized controlled trial conducted in the Affiliated Hangzhou Chest Hospital of Zhejiang University will include a total of 80 patients. Patients who meet the inclusion criteria will be randomly assigned to either the six-month (n=40) or nine-month (n=40) treatment group. The primary outcome will be complete response, which is defined as endoscopy displaying active lesion healing at the end of treatment. Participants will be scheduled for follow-up visits once a month in the first three months, then once every three months until the end of the treatment. The last follow-up will be one year after the treatment. Recurrence will be assessed one year after the end of treatment, which is defined as endoscopy displaying recurrent lesions after complete response. DISCUSSION: In addition to the reports of tuberculous lymphadenitis and spinal TB, there are few appropriate randomized trials for the treatment of extrapulmonary TB with appropriate clinical endpoints. We believe that the proposed randomized controlled trial will provide further data on the efficacy of short-term six-month anti-TB therapy in intestinal TB patients. TRIAL REGISTRATION: This trial will be registered on ClinicalTrial.gov.


Assuntos
COVID-19 , Tuberculose dos Linfonodos , Humanos , Estudos Multicêntricos como Assunto , Ensaios Clínicos Controlados Aleatórios como Assunto , SARS-CoV-2 , Resultado do Tratamento
7.
Front Immunol ; 12: 731933, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34484243

RESUMO

Background: Pyroptosis is a new programmed cell death discovered in recent years. Pyroptosis plays an important role in various diseases. Nevertheless, there are few bibliometric analysis systematically studies this field. We aimed to visualize the research hotspots and trends of pyroptosis using a bibliometric analysis to help understand the future development of basic and clinical research. Methods: The articles and reviews regarding pyroptosis were culled from Web of Science Core Collection. Countries, institutions, authors, references and keywords in this field were visually analyzed by using CtieSpace and VOSviewer software. Results: A total of 2845 articles and reviews were included. The number of articles regarding pyroptosis significantly increased yearly. These publications mainly come from 70 countries led by China and the USA and 418 institutions. We identified 605 authors, among which Thirumaladevi Kanneganti had the most significant number of articles, and Shi JJ was co-cited most often. Frontiers in immunology was the journal with the most studies, and Nature was the most commonly cited journal. After analysis, the most common keywords are nod like receptor family pyrin domain containing 3 inflammasome, apoptosis, cell death, gasdermin D, mechanism, caspase-1, and others are current and developing areas of study. Conclusion: Research on the pyroptosis is flourishing. Cooperation and exchanges between countries and institutions must be strengthened in the future. The related pathway mechanism of pyroptosis, the relationship between pyroptosis and other types of programmed cell deaths as well as the role of pyroptosis in various diseases have been the focus of current research and developmental trends in the future research.

8.
Int J Pharm ; 608: 121078, 2021 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-34500059

RESUMO

Cancer is still a major threat for human life, and the cancer immunotherapy can be more optimized to prolong life. However, the effect of immunotherapy is not encouraging. In order to achieve outstanding immune effect, it is necessary to strengthen antigens uptake of antigen presenting cells. Adjuvants were added to vaccines to achieve this purpose, which could be divided into two types: as an immunostimulatory molecule, the innate immunities of the body were triggered; or as a delivery carrier, and antigens were cross-delivery through the "cytoplasmic pathway" and released at a specific location. This paper reviewed the relevant research status of tumor vaccine immune adjuvants in recent years. Among the review, the function, combination strategies and derivatives of lipid A were discussed in detail. In addition, some suggestions on the existing problems and research direction of lipids as tumor vaccine adjuvants were put forward.

9.
Sci Total Environ ; 805: 150302, 2021 Sep 11.
Artigo em Inglês | MEDLINE | ID: mdl-34536880

RESUMO

The risk of graphene oxide (GO) exposure to various species has been greatly amplified in recent years due to its booming production and applications in various fields. However, a deep understanding of the GO biosafety lags its wide applications. Herein, we used W1118 flies as a model organism to study GO toxicity at relatively low concentrations. We found that GO exposure led to remarkable weight loss, delayed development, retarded motion, and shortened lifespan of these flies. On the other hand, the GO influence on their sex ratio and the total number of pupae and adults were insignificant. The toxicological effect of GO was shown to be related to its serious compromise of the nutrient absorption in flies due to the severe damages in midguts. These damages were then attributed to the excessive accumulation of reactive oxygen species (ROS), which triggers the oxidative stress. These findings reveal the underlying mechanisms of GO biotoxicities in fruit flies, which might provide a useful reference to assess the risks of these newly invented nanomaterials likely never encountered by various species before.

10.
Biomed Environ Sci ; 34(8): 650-655, 2021 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-34474727

RESUMO

Epstein-Barr virus (EBV) and cytomegalovirus (CMV), two of the most prevalent human herpesviruses, cause a wide spectrum of diseases and symptoms and are associated with serious health problem. In this study, we developed an internal control reference recombinase-aided amplification (ICR-RAA) assay for the rapid detection of EBV and CMV within 30 min. The assay had a sensitivity of 5 and 1 copies/test for EBV and CMV, respectively, with no cross reaction with other pathogens. In comparison with those of the commercial quantitative polymerase chain reaction (qPCR), the sensitivity of the EBV and CMV ICR-RAAs using extracted DNA was 93.33% and 84.84%, respectively; the specificity was 98.75% and 100.00%, respectively; and the Kappa values were 0.930 and 0.892 ( P < 0.05), respectively. In comparison with those of qPCR, the sensitivity of the EBV and CMV ICR-RAAs using the DNA by thermal lysis was 72.22% and 80.00%, respectively; the specificity was 100.00%; and the Kappa values were 0.764 and 0.878 ( P < 0. 05), respectively. Thus, rapid and specific detection of EBV and CMV is possible using ICR-RAA assays.

11.
J Steroid Biochem Mol Biol ; 214: 105956, 2021 Aug 02.
Artigo em Inglês | MEDLINE | ID: mdl-34348182

RESUMO

BACKGROUND: The role of calcitriol (1,25-dihydroxyvitamin D3 or 1,25-(OH)2D3) in physiological processes, such as anti-fibrosis, anti-inflammation, and immunoregulation is known; however, its role in the remodeling of the glomerular capillary endothelium in rats with chronic renal failure (CRF) remains unclear. METHODS: Here, we analyzed the role/number of endothelial progenitor cells (EPCs), renal function, and pathological alterations in rats with CRF, and compared the results before and after supplementation with calcitriol in vivo. RESULTS: Amongst the three experimental groups (sham group, CRF group, and calcitriol-treated group (0.03 µg/kg/d), we observed substantially elevated cell adhesion and vasculogenesis in vivo in the calcitriol-treated group. Additionally, lower levels of serum creatinine (Scr) and blood urea nitrogen (BUN) was recorded in the calcitriol-treated group than the CRF group (p > 0.05). Calcitriol treatment also resulted in an improvement in renal pathological injury. CONCLUSIONS: Thus, calcitriol could ameliorate the damage of glomerular arterial structural and renal tubules vascular network integrity, maybe through regulating the number and function of EPCs in the peripheral blood of CRF rats. Treatment with it may improve outcomes in patients with renal insufficiency or combined cardiac insufficiency. Calcitriol could ameliorate CRF-induced renal pathological injury and renal dysfunction by remodeling of the glomerular capillary endothelium, thus, improving the function of glomerular endothelial cells.

13.
Plant Dis ; 2021 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-34406785

RESUMO

Peach shoot blight (PSB), which kills shoots, newly sprouted leaf buds and peach fruits, has gradually increased over the last ten years and has resulted in 30-50% of the total production loss of the peach industry in China. Phomopsis amygdali has been identified as the common causal agent of this disease. In this study, two new species, Phomopsis liquidambaris (strain JW18-2) and Diaporthe eres (strain JH18-2), were also pathogens causing PSB, as determined through molecular phylogenetic analysis based on the sequences of the internal transcribed spacer region (ITS), translation elongation factor 1-α (EF1-α) and beta-tubulin (TUB), and colony and conidial morphological characteristics. Biological phenotypic analysis showed that the colony growth rate of strain JW18-2 was faster than that of strains JH18-2 and ZN32 (one of the P. amygdali strains that we previously found and identified). All three strains produced α-conidia; however, JW18-2 could not produce ß-conidia on alfalfa decoction and Czapek media, and the ß-conidia produced by strain JH18-2 were shorter in length and thicker in width than those produced by strain ZN32. Pathogenicity tests showed that JW18-2 presented the strongest pathogenicity for peach fruits and twigs and was followed by strains JH18-2 and ZN32. The results shed light on the etiology of PSB and provide a warning that P. liquidambaris or D. eres might develop into dominant species after a few years, while also potentially benefitting the development of effective disease control management strategies.

14.
IEEE Trans Biomed Eng ; PP2021 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-34357861

RESUMO

Using deep neural networks (DNNs) to explore spatial patterns and temporal dynamics of human brain activities has been an important yet challenging problem because the artificial neural networks are hard to be designed manually. There have been several promising deep learning methods, e.g., deep belief network (DBN), convolutional neural network (CNN), and deep sparse recurrent auto-encoder (DSRAE), that can decompose neuroscientific and meaningful spatiotemporal patterns from 4D functional Magnetic Resonance Imaging (fMRI) data. However, those previous studies still depend on hand-crafted neural network architectures and hyperparameters, which are not optimal in various senses. In this paper, we employ the evolutionary algorithms (EA) to optimize the deep neural architecture of DSRAE by minimizing the expected loss of initialized models, named eNAS-DSRAE (evolutionary Neural Architecture Search on Deep Sparse Recurrent Auto-Encoder). Also, validation experiments are designed and performed on the publicly available human connectome project (HCP) 900 datasets, and the results achieved by the optimized eNAS-DSRAE suggested that our framework can successfully identify the spatiotemporal features and perform better than the hand-crafted neural network models. To our best knowledge, the proposed eNAS-DSRAE is not only among the earliest NAS models that can extract connectome-scale meaningful spatiotemporal brain networks from 4D fMRI data, but also is an effective framework to optimize the RNN-based models.

15.
Water Res ; 202: 117463, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34358906

RESUMO

Sulfonamides (SAs) are among the most widely used antibiotics to treat bacterial infections for humans and animals. They are also used in livestock agriculture to improve growth and feed efficiency in many countries. Recent years, there is a growing concern about the environmental fate and treatment technologies of SAs, in order to eliminate their potential impact on the ecosystem and human health. Additionally, SAs are frequently used as model compounds to evaluate the performance of newly developed advanced water treatment processes. Hence, understanding the chemical reaction features of SAs can provide valuable information for further technological development. In this review, the reaction kinetics, abiotic transformations and corresponding ecotoxicity changes of SAs in natural environments and water treatment processes were comprehensively analyzed to draw critical suggestion and new insights. The •OH-based AOP is proposed as an effective method for the elimination of SAs toxicity, although it is susceptible to water constituent due to low selectivity. The application of biochar or metal-based oxidants in AOPs is becoming a future trend for SA treatment. Overall, this review would provide useful information for the development of advanced water treatment technologies and the control of ecological risks related to SAs.


Assuntos
Poluentes Químicos da Água , Purificação da Água , Animais , Antibacterianos/toxicidade , Ecossistema , Humanos , Sulfonamidas/toxicidade , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/toxicidade
16.
J Mater Sci Mater Med ; 32(9): 105, 2021 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-34420103

RESUMO

Tissue engineering is a promising approach for bone regeneration. In this study, we aimed to investigate whether tissue engineered periosteum (TEP), which was fabricated by combining osteogenically-induced mesenchymal stem cells (MSCs) with porcine small intestinal submucosa (SIS), could restore long bone defects of large size in rabbits. Twenty-four adult New Zealand white rabbits (NZWRs) were used in the experiments. Long bone defects of large size (30 mm-50 mm; average, 40 mm) were established on both sides of NZWRs' radii. The defects were treated with TEP (Group A), allogeneic deproteinized bone (DPB, Group B), TEP combined with DPB (Group C), and pure SIS (Group D). The healing outcome was evaluated by radiography and histological examination at 4, 8, and 12 weeks post-treatment. The radiographical findings showed that bone defects of large size were all repaired in Groups A, B and C within 12 weeks, whereas Group D (pure SIS group) failed to result in defect healing at 4, 8, and 12 weeks. Although there was some new bone regeneration connecting the allografts and bone ends, as observed under radiographical and histological observations, bone defects of large sizes were restored primarily by structurally allografted DPB within 12 weeks. The TEP groups (Groups A and C) showed partial or total bone regeneration upon histological inspection. Based on 12-week histological examinations, significantly more bone was formed in Group A than Group C (P < 0.05), and both groups formed significantly more bone than in Groups B and D. The results indicated that long bone defects of a large size could be restored by TEP or TEP combined with the DPB scaffold, and such materials provide an alternative approach to resolving pathological bone defects in clinical settings.

17.
Proc Natl Acad Sci U S A ; 118(36)2021 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-34462354

RESUMO

The molecular events that determine the recycling versus degradation fates of internalized membrane proteins remain poorly understood. Two of the three members of the SNX-FERM family, SNX17 and SNX31, utilize their FERM domain to mediate endocytic trafficking of cargo proteins harboring the NPxY/NxxY motif. In contrast, SNX27 does not recycle NPxY/NxxY-containing cargo but instead recycles cargo containing PDZ-binding motifs via its PDZ domain. The underlying mechanism governing this divergence in FERM domain binding is poorly understood. Here, we report that the FERM domain of SNX27 is functionally distinct from SNX17 and interacts with a novel DLF motif localized within the N terminus of SNX1/2 instead of the NPxY/NxxY motif in cargo proteins. The SNX27-FERM-SNX1 complex structure reveals that the DLF motif of SNX1 binds to a hydrophobic cave surrounded by positively charged residues on the surface of SNX27. The interaction between SNX27 and SNX1/2 is critical for efficient SNX27 recruitment to endosomes and endocytic recycling of multiple cargoes. Finally, we show that the interaction between SNX27 and SNX1/2 is critical for brain development in zebrafish. Altogether, our study solves a long-standing puzzle in the field and suggests that SNX27 and SNX17 mediate endocytic recycling through fundamentally distinct mechanisms.

18.
Acta Pharmacol Sin ; 2021 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-34462562

RESUMO

Large amounts of tumor-associated macrophages (TAM), which are predominately localized in hypoxia area of the tumor tissue, are associated with the malignant progression of the tumor. In the present study, we investigated the inhibitory effects of modified citrus pectin (MCP), a natural dietary polysaccharide, on the survival and polarization of TAM in relation to its inhibition on the growth and migration of breast cancer. M2 macrophages polarized from human monocyte THP-1 were chosen as a model for TAM. We showed that MCP (0.06%-1%) concentration-dependently suppressed the survival of TAM through inhibiting glucose uptake with a greater extent in hypoxia than in normoxia. Furthermore, MCP treatment decreased ROS level in TAM through its reducibility and inhibiting galectin-3 expression, leading to inhibition of glucose transporter-1 expression and glucose uptake. In addition, MCP suppressed M2-like polarization via inhibiting STAT3 phosphorylation. Moreover, the tumor-promoting effect of TAM could be restrained by MCP treatment as shown in human breast cancer MDA-MB-231 cells in vitro and in mouse breast cancer 4T1-luc orthotopic and metastasis models. In both tumor tissue and lung tissue of the mouse tumor models, the number of TAM was significantly decreased after MCP treatment. Taken together, MCP may be a promising agent for targeting TAM in tumor hypoxic microenvironment for breast cancer treatment.

19.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 29(4): 1295-1300, 2021 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-34362519

RESUMO

OBJECTIVE: To investigate the clinical characteristic of coagulation, possible causes and countermeasures of patients with severe corona virus disease 2019 (COVID-19). METHODS: The clinical data of the 142 patients diagnosed as COVID-19 at Wuhan Third Hospital in Wuhan, China, from February 10 to February 16, 2020 were collected and analyzed retrospective. Among the patients, 17 cases of dead patients were divided into observe group, and 125 cases of cured patients were divided into control group. The clinical characteristics, laboratory tests, influencing factors, anticoagulant therapy, embolization and bleeding events of the two groups were observed. RESULTS: The average hospital stay time in 142 patients was 22 d. For the 17 dead patients in the observe group, the average hospital stay time was 9.9 d, and the D-dimer, prothrombin time, WBC count and Padua score of the patients in the observe group were significantly higher as compared with the patients in the control group. PT(OR=1.064, 95%CI 1.012-1.119) and D-D(OR=1.045, 95%CI 1.027-1.064) were the independent risk factors that causing the death of COVID-19 patients. Among the patients, 36(25.4%) patients received low-molecular-weight heparin for anticoagulant therapy, with the average course of 9.6 d. The cumulative incidence of the embolism of the patients in the observe group was 7(41.2%), while 2(11.8%) patients developed to deep vein thrombosis (DVT) and pulmonary embolism (PE), 3 (17.6%) patients occurred acute cerebral infarction and 2 (11.8%) patients occurred acute myocardial infarction. 3 (17.6%) dead patients revealed dominant disseminated intravascular coagulation (DIC). CONCLUSION: Most patients with severe COVID-19 shows a variety of risk factors for thrombus, and those with coagulation dysfunction shows a high dead rate and rapid disease progression. Therefore, coagulation indicators should be dynamically monitored, and mechanical and drug prevention should be actively carried out.


Assuntos
COVID-19 , Coagulação Intravascular Disseminada , Anticoagulantes , Humanos , Estudos Retrospectivos , SARS-CoV-2
20.
Sci Rep ; 11(1): 16210, 2021 Aug 10.
Artigo em Inglês | MEDLINE | ID: mdl-34376708

RESUMO

With the increased incidence and recognition, ulcerative colitis (UC) has become a global public health problem in the world. Although many immunosuppressant and biological drugs have been used for UC treatment, the cure rate is still very low. It is necessary to find some safe and long-term used medicine for UC cure. Recently, the Chinese traditional herb Danshen has been investigated in the treatment of UC. However, it is a limitation of Danshen that many of the active components in Danshen are not easily absorbed by the human body. Probiotics could convert macromolecules into smaller molecules to facilitate absorption. Thus, Lactobacillus rhamnosus (F-B4-1) and Bacillus subtillis Natto (F-A7-1) were screened to ferment Danshen in this study. The fermented Danshen products were gavaged in the dextran sulfate sodium (DSS)-induced UC model mice. Danshen had better results to attenuate symptoms of DSS-induced UC after fermented with F-B4-1 and F-A7-1. Loss of body weight and disease activity index (DAI) were reduced. The abnormally short colon lengths and colonic damage were recovered. And fermented Danshen had the better inhibitory effect than Danshen itself on pro-inflammatory cytokine expression during DSS-induced UC. The results indicated that compared with Danshen, fermented Danshen relieved DSS-induced UC in mice more effectively. Danshen fermented by probiotics might be an effective treatment to UC in clinic stage in the future.

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