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1.
Opt Express ; 29(22): 35891-35899, 2021 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-34809013

RESUMO

Metasurfaces have shown promising applications in radar-infrared compatible stealth because of its superior electromagnetic wave control capabilities, but, to date, the majority of designs still suffer from the defects of large thickness, limited working bandwidth, relatively high infrared emissivity and so on. Here, an exotic phase gradient metasurface (PGM) is proposed to achieve low microwave reflection and low infrared emission concurrently, which has a small thickness of about 0.10λ0. The microwave reflection reduction larger than 10 dB in 14-20 GHz is attributed to the anomalous reflection for arbitrary LP incident waves, and the infrared emissivity less than 0.28 from 3 to 14 µm is due to the indium-tin-oxide (ITO) with low infrared emissivity and high filling ratio. Also, the designed PGM can also realize beam deflection for orthogonal CP waves because of the meta-atoms' isotropic characteristics. Our methodology is fully verified by numerous simulations and experiments and may open a new avenue for radar-infrared compatible stealth research.

2.
Acta Ophthalmol ; 2021 Aug 17.
Artigo em Inglês | MEDLINE | ID: mdl-34403203

RESUMO

PURPOSE: In eyes with diabetic macular oedema (DME), aqueous humour (AH) cytokine levels before and after anti-vascular endothelial growth factor (VEGF) treatment were compared and correlated with optical coherence tomography structural parameters. METHODS: This prospective study included 56 control patients with cataracts and 83 patients with DME manifesting as diffuse retinal thickening (DRT), cystoid macular oedema and serous retinal detachment (SRD). AH samples were obtained before intravitreal injection of anti-VEGF or cataract surgery. VEGF, interleukin (IL)-6, IL-8, IL-10, interferon-inducible protein 10 (IP-10) and monocyte chemotactic protein 1 (MCP-1) levels were measured by multiplex bead assay. AH cytokine levels, central macular thickness (CMT), number of hyper-reflective foci (HF), continuity of external limiting membrane and ellipsoid zone (EZ) and best-corrected visual acuity were evaluated. RESULTS: In SRD, IL-6 and MCP-1 levels and HF were increased (all p < 0.05) compared to DRT. At baseline, the number of HF was correlated with VEGF, IL-6, IL-8, IP-10 and MCP-1 (all p < 0.05). Eyes sensitive to anti-VEGF treatment had high baseline levels of VEGF, MCP-1, HF and many EZ disruptions (all p < 0.05). DME patients with normal VEGF levels but with high levels of IL-8, IP-10 and MCP-1 (all p < 0.05) had little change in CMT after anti-VEGF treatment (p = 0.678). CONCLUSIONS: AH concentrations of some inflammatory cytokines in DME were differentially expressed among the three DME morphologies. HF was associated with VEGF and other inflammatory cytokine levels. Multiple HF at baseline predicted a significant decrease in CMT, and eyes with normal VEGF but increased inflammatory cytokines may be insensitive to anti-VEGF treatment.

3.
BMC Ophthalmol ; 21(1): 242, 2021 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-34058993

RESUMO

BACKGROUND: Choroidal osteoma is a benign intraocular tumor that can increase risk of developing choroidal neovascularization. The visual prognosis is influenced by the tumor location, decalcification status, overlying RPE atrophy, presence of choroidal neovascularization, persistence of subretinal fluid and occurrence of subretinal hemorrhages. CASE PRESENTATION: The authors present a 40-year-old woman diagnosed with choroidal osteoma of the right eye. Her best corrected visual acuity was 12/20 but decreased to 5/20 due to secondary choroidal neovascularization after 8 years follow up. Fundus examination revealed an enlarged choroidal osteoma in most margins at posterior pole with schistose hemorrhage beside macula. Optical coherence tomography angiography revealed unique features in the vascular changes of choroidal neovascularization in choroidal osteoma in the outer retinal layer and choroid capillary layers, and subretinal neovascularization. Indocyanine green fluorescence angiography showed there was hypo-fluorescence at the peripapillary with faint hyper-fluorescence at the macular, corresponding to the location on the fundus photograph. The patient received 3 injections of intravitreal ranibizumab. After 1 year follow up, her visual acuity of the right eye was 18/20 and the CNV had regressed. CONCLUSIONS: We present the findings and treatment of a case of choroidal osteoma with secondary choroidal neovascularization. Optical coherence tomography angiography combined with FFA and ICGA is used to analysis the characteristics of secondary choroidal neovascularization. Optical coherence tomography angiography can reveal some unique characteristics in the vascular changes compared to fundus fluorescein angiography.


Assuntos
Neovascularização de Coroide , Osteoma , Adulto , Inibidores da Angiogênese/uso terapêutico , Corioide , Neovascularização de Coroide/diagnóstico , Neovascularização de Coroide/tratamento farmacológico , Neovascularização de Coroide/etiologia , Feminino , Seguimentos , Humanos , Osteoma/complicações , Osteoma/diagnóstico , Osteoma/tratamento farmacológico
4.
Water Res ; 200: 117259, 2021 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-34058481

RESUMO

Electrochemical advanced oxidation processes (EAOPs) have emerged as a promising water treatment alternative but major breakthroughs are still needed in order for EAOPs to be competitive with traditional treatment technologies in terms of energy cost. Most existing studies have been conducted at high potentials to generate the powerful hydroxyl radical oxidant (aqueous •OH). While adsorbed hydroxyl radicals (OH*) may form at a much lower energy cost, their possible utilization is limited due to the poor mass transfer of this highly reactive species on solid electrodes. In this report, we describe a novel flow anode system using 4-16 µm Magnéli phase titanium suboxide particles as the anode material which enables the generation of a high steady state •OH concentration (5.4 × 10-12 mol m-2) at only 1.5 V (vs SHE) in a dilute electrolyte (5 mM KH2PO4). The energy cost of removal per order of selected water contaminants (tetracycline and orange II in this study) using the flow anode is 1.5--6.7 Wh m-3, which is 1 - 4 orders of magnitude lower than that of existing techniques. The anode material used demonstrates great stability with the configuration readily scaled up. The results of this study provide new insight into a high efficiency, low cost water treatment technology for organic contaminant degradation.


Assuntos
Poluentes Químicos da Água , Purificação da Água , Eletrodos , Radical Hidroxila , Oxirredução , Água
5.
Int J Ophthalmol ; 14(5): 719-724, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34012887

RESUMO

AIM: To compare the safety and efficacy of conbercept intravitreal injection and half-dose photodynamic therapy (PDT) in treating chronic central serous chorioretinopathy (CSC). METHODS: This study was retrospective. Thirty-seven patients (37 eyes) with chronic CSC received conbercept injections while 57 patients (57 eyes) were treated with half-dose PDT. All subjects were followed in 6mo. Outcome measures included change in best-corrected visual acuity (BCVA), central macular thickness (CMT), subfoveal choroidal thickness (SFCT), and resolution of subretinal fluid (SRF). RESULTS: There was no adverse event observed in either treatment group. At the 6-month follow-up, 26 eyes (70.3%) in the conbercept group and 54 eyes (94.7%) in the half-dose PDT group (P<0.05) reached full resolution of SRF. The mean logarithm of the minimum angle of resolution (logMAR) BCVA significantly improved (P<0.001) in both treatment groups with better outcome at early phase in the half-dose PDT group (2wk, 1, and 2mo, P<0.05). All subjects experienced significant CMT improvement (P<0.001) with no statistical difference between the two groups (P>0.05). The SFCT also improved in all subjects (P<0.001) with better outcome in the half-dose PDT group (P<0.05). CONCLUSION: Both intravitreal conbercept and half-dose PDT are safe to use in treating chronic CSC. By 6mo, both treatment groups are efficacious in improving BCVA, reducing CMT and SFCT, and resolving SRF in eyes with chronic CSC. Half-dose PDT may show better outcome at initial phase of treatment in chronic CSC. Longer follow-up period is necessary to study for long-term effect and safety.

6.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi ; 35(4): 458-463, 2021 Apr 15.
Artigo em Chinês | MEDLINE | ID: mdl-33855830

RESUMO

Objective: To investigate the efficacy and safety of over-bending rod reduction and fixation technique via posterior approach in the treatment of unstable fresh thoracolumbar burst fracture. Methods: A clinical data of 27 patients with unstable fresh thoracolumbar burst fracture, who were met the inclusive criteria and admitted between January 2018 and October 2019, was retrospectively analyzed. There were 15 males and 12 females with an average age of 41.8 years (range, 26-64 years). The fractures were caused by falling from height in 14 cases, traffic accident in 8 cases, and crushing by a heavy objective in 5 cases. The interval between injury and operation was 1-7 days (mean, 3.2 days). The injured fracture was located at T 10 in 1 case, T 11 in 3 cases, T 12 in 6 cases, L 1 in 7 cases, L 2 in 7 cases, and L 3 in 3 cases. According to AO classification, there were 11 cases of type A3, 7 cases of type B, and 9 cases of type C. Neurological function was rated as grade A in 3 cases, grade B in 7 cases, grade C in 5 cases, and grade D in 12 cases according to the American Spinal Injury Association (ASIA) grading. All cases were treated by over-bending rod reduction and fixation technique via posterior approach, and 16 cases were combined with limited fenestration decompression. The evaluation indicators consisted of operation time, intraoperative blood loss, the compression ratio of the anterior vertebral height, the invasion rate of the injured vertebra into the spinal canal, the Cobb angle of segmental kyphosis, visual analogue scale (VAS) score, and Oswestry Disability Index (ODI). Results: The operation time was 67-128 minutes (mean, 81.6 minutes), and the intraoperative blood loss was 105-295 mL (mean, 210 mL). All patients were followed up 12-23 months (mean, 17.2 months). A total of 178 pedicle screws were implanted during operation, and the accuracy of the implantation was 98.9% (176/178). The compression ratios of the anterior vertebral height at the early postoperatively and last follow-up were significantly increased when compared with preoperative one ( P<0.05), and the invasion rate of the injured vertebra into the spinal canal, Cobb angle, VAS score, and ODI were significantly lower than those preoperatively ( P<0.05). Except that the ODI at last follow-up was significantly lower than that of the early postoperative period ( P<0.05), there was no significant difference between the last follow-up and the early postoperative period for other indicators ( P>0.05). At last follow-up, the neurological function was rated as grade A in 1 case, grade B in 2 cases, grade C in 4 cases, grade D in 9 cases, and grade E in 11 cases according to the ASIA grading, showing significant difference when compared with that before operation ( Z=-3.446, P=0.001). Conclusion: Over-bending rod reduction and fixation technique can effectively restore vertebral height, reset the invaded vertebral block, and selectively perform limited decompression and posterolateral bone grafting to ensure the completeness of intravertebral decompression and stability, which is one of the effective methods to treat unstable fresh thoracolumbar burst vertebral fracture.


Assuntos
Fraturas da Coluna Vertebral , Vértebras Torácicas , Adulto , Descompressão Cirúrgica , Feminino , Fixação Interna de Fraturas , Humanos , Vértebras Lombares/lesões , Vértebras Lombares/cirurgia , Masculino , Estudos Retrospectivos , Fraturas da Coluna Vertebral/cirurgia , Vértebras Torácicas/lesões , Vértebras Torácicas/cirurgia , Resultado do Tratamento
7.
Medicine (Baltimore) ; 100(10): e24030, 2021 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-33725816

RESUMO

ABSTRACT: The aim of the study was to determine if multiple intraspinal anomalies increase the risk of scoliosis correction compared to the normal intraspinal condition or 1 or 2 intraspinal anomalies in congenital scoliosis (CS) and whether correction for multiple intraspinal anomalies need to be performed with preliminary neurosurgical intervention before scoliosis correction.A total of 318 consecutive CS patients who underwent corrective surgery without preliminary neurosurgical intervention at a single institution from 2008 to 2016 were retrospectively reviewed, with a minimum of 2 years of follow-up. The patients were divided into 3 groups according to different intraspinal conditions. In the normal group (N group; n = 196), patients did not have intraspinal anomalies. In the abnormal group (A group; n = 93), patients had 1 or 2 intraspinal anomalies. In the multiple anomaly group (M group; n = 29), patients had 3 or more intraspinal anomalies including syringomyelia, split cord malformation [SCM], tethered cord, low conus, intraspinal mass, Chiari malformation or/and arachnoid cyst. The occurrence of complications as well as perioperative and radiographic data were analyzed.The incidence rate of multiple intraspinal anomalies in CS patients was 9.1% (29/318). No significant difference was observed in the perioperative outcomes or radiographic parameters at the final follow-up. There were no significant differences among the 3 groups in the total, major or neurological complication rates (all P > .05). Two patients (1 in the N group and 1 in the A group) experienced transient neurological complications, whereas no patient experienced permanent neurological deficits during surgery or follow-up.To our knowledge, the current study reported the largest cohort of intraspinal anomalies in patients with CS that has been reported in the literature. The results of our study demonstrated that patients with congenital scoliosis associated with intraspinal anomalies, even multiple intraspinal anomalies that coexist with more complex intraspinal pathologies, may safely and effectively achieve scoliosis correction without preliminary neurological intervention. More complex intraspinal pathologies do not seem to increase the risk of neurosurgical complications during corrective surgery.


Assuntos
Anormalidades Múltiplas/cirurgia , Procedimentos Ortopédicos/efeitos adversos , Complicações Pós-Operatórias/epidemiologia , Escoliose/cirurgia , Doenças da Medula Espinal/complicações , Medula Espinal/anormalidades , Anormalidades Múltiplas/epidemiologia , Adolescente , Tomada de Decisão Clínica , Feminino , Seguimentos , Humanos , Masculino , Procedimentos Neurocirúrgicos/normas , Procedimentos Neurocirúrgicos/estatística & dados numéricos , Procedimentos Ortopédicos/normas , Procedimentos Ortopédicos/estatística & dados numéricos , Complicações Pós-Operatórias/etiologia , Estudos Retrospectivos , Escoliose/complicações , Escoliose/congênito , Escoliose/epidemiologia , Medula Espinal/cirurgia , Doenças da Medula Espinal/epidemiologia , Doenças da Medula Espinal/cirurgia , Coluna Vertebral/diagnóstico por imagem , Coluna Vertebral/cirurgia , Tomografia Computadorizada por Raios X , Resultado do Tratamento
8.
Sci Rep ; 11(1): 3628, 2021 02 11.
Artigo em Inglês | MEDLINE | ID: mdl-33574559

RESUMO

Long non-coding RNA growth arrest specific transcript 5 (GAS5) has been found to be implicated in the pathogenesis of central nervous diseases and to be a contributor to hypoxic brain injury. However, the roles and molecular mechanisms of GAS5 in spinal cord injury (SCI) have not thoroughly investigated. Here, we reported that GAS5 knockdown improved rat locomotor function and alleviated pathological damage of spinal cord tissues by reducing oxidative stress, caspase-3 activity and vav guanine nucleotide exchange factor 1 (VAV1) expression in SCI rat models. GAS5 knockdown inhibited the increase of malondialdehyde (MDA) level and cell apoptotic rate induced by oxygen-glucose deprivation (OGD) and weakened the inhibitory effects of OGD on superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and cell viability in RN-Sc cells, suggesting that GAS5 loss mitigated OGD-triggered oxidative stress and cell injury in RN-Sc cells. Molecular mechanism explorations revealed that GAS5 recruited CUGBP, Elav-like family member 2 (CELF2) to the coding region of VAV1 mRNA, resulting in the increase of VAV1 mRNA stability and expression levels. VAV1 knockdown weakened OGD-induced oxidative stress and cell injury in RN-Sc cells. VAV1 loss alleviated GAS5-induced oxidative stress and cell injury in OGD-treated RN-Sc cells. As a conclusion, our findings suggested that GAS5 aggravated SCI by increasing VAV1 expression via binding with CELF2, deepening our understanding on function and molecular basis of GAS5 in SCI.


Assuntos
Proteínas CELF/metabolismo , Regulação da Expressão Gênica , Técnicas de Silenciamento de Genes , Proteínas Proto-Oncogênicas c-vav/genética , RNA Nucleolar Pequeno/genética , Traumatismos da Medula Espinal/genética , Traumatismos da Medula Espinal/patologia , Animais , Apoptose/genética , Modelos Animais de Doenças , Glucose/deficiência , Masculino , Estresse Oxidativo/genética , Oxigênio , Proteínas Proto-Oncogênicas c-vav/metabolismo , Estabilidade de RNA , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , RNA Nucleolar Pequeno/metabolismo , Ratos Wistar
9.
J Cell Physiol ; 236(3): 2144-2155, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-32761843

RESUMO

Ginsenoside Rb1 (GRb1), a major ingredient of ginseng, has been found to be a potential protective agent in spinal cord injury (SCI) and in activated microglia-induced neuronal injury. This study discovered that GRb1 could facilitate miR-130b-5p expression in SCI rats and Toll-like receptor 4 (TLR4; a crucial player in inflammation) was a potential target of miR-130b-5p. Hence, we further investigated whether GRb1 could relieve SCI by reducing microglia-mediated inflammatory responses and neuronal injury via miR-130b-5p/TLR4 pathways. The results showed that GRb1 alleviated SCI through inhibiting neuronal apoptosis and proinflammatory factor expression via increasing miR-130b-5p.GRb1 weakened the damage of activated microglia to neurons through upregulating miR-130b-5p. miR-130b-5p attenuated activated microglia-induced neuron injury via targeting TLR4. GRb1 inactivated TLR4/nuclear factor-κB (NF-κB) activation and inhibited proinflammatory cytokine secretion by increasing miR-130b-5p in activated microglia. As a conclusion, GRb1 alleviated SCI through reducing activated microglia-induced neuronal injury via miR-130b-5p/TLR4/NF-κB axis, providing a deep insight into the molecular basis of GRb1 in the treatment of SCI.


Assuntos
Ginsenosídeos/uso terapêutico , MicroRNAs/metabolismo , Microglia/patologia , NF-kappa B/metabolismo , Transdução de Sinais , Traumatismos da Medula Espinal/tratamento farmacológico , Traumatismos da Medula Espinal/genética , Receptor 4 Toll-Like/metabolismo , Regiões 3' não Traduzidas/efeitos dos fármacos , Animais , Apoptose , Sequência de Bases , Citocinas/metabolismo , Ginsenosídeos/farmacologia , Glucose/deficiência , Mediadores da Inflamação/metabolismo , Masculino , MicroRNAs/genética , Microglia/efeitos dos fármacos , Microglia/metabolismo , Neurônios/efeitos dos fármacos , Neurônios/metabolismo , Neurônios/patologia , Fármacos Neuroprotetores/farmacologia , Fármacos Neuroprotetores/uso terapêutico , Oxigênio , Ratos Wistar , Regulação para Cima/efeitos dos fármacos
10.
World Neurosurg ; 144: e9-e14, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32540291

RESUMO

OBJECTIVE: To compare the pedicle morphology of nondystrophic scoliosis secondary to neurofibromatosis type 1 (ND-NF1) scoliosis secondary to neurofibromatosis type 1 (NF1-S) and adolescent idiopathic scoliosis (AIS) using computed tomography (CT) in a consistent classification system. METHODS: The transverse pedicle widths of cancellous and cortical channels were measured using preoperative spinal CT images (T1-L5) and then classified as having type A-E pedicles; type B, C, D, and E pedicles were regarded as abnormal. A subset of these patients, a postoperative CT was performed to evaluate the accuracy of pedicle screw placement. According to the perforation of the medial or lateral pedicle walls by the pedicle screw, the placement of screw was classified by a grade ranging from 0 to 3, and grades 2 and 3 were regarded as misplacement. RESULTS: In total, 3230 pedicles were measured and classified, and the incidence rate of abnormal pedicles in the ND-NF1 group was significantly greater than that of the AIS group (65.9% vs. 61.4%, P = 0.03). The misplacement rate in the ND-NF1 group was significantly greater than that in the AIS group (12.2% vs. 7.4%; P = 0.01), and in terms of the corresponding 1100 pedicles, the incidence rate of abnormal pedicles in the ND-NF1 group was higher than that in the AIS group (71.7% vs. 64.9%; P = 0.02). CONCLUSIONS: The incidence rate of abnormal pedicles in patients with ND-NF1 is significantly greater than that of patients with AIS, and it may the reason for the higher misplacement rate of pedicle screws in patients with ND-NF1.


Assuntos
Neurofibromatose 1/complicações , Neurofibromatose 1/diagnóstico por imagem , Escoliose/diagnóstico por imagem , Escoliose/etiologia , Vértebras Torácicas/patologia , Adolescente , Criança , Feminino , Humanos , Incidência , Masculino , Erros Médicos , Procedimentos Neurocirúrgicos , Parafusos Pediculares , Estudos Retrospectivos , Escoliose/cirurgia , Vértebras Torácicas/cirurgia , Tomografia Computadorizada por Raios X
11.
Int J Ophthalmol ; 11(7): 1217-1221, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30046542

RESUMO

AIM: To evaluate the safety and efficacy of intravitreal conbercept (IVC) injections as pretreatment for pars plana vitrectomy (PPV) in severe proliferative diabetic retinopathy (PDR). METHODS: This was a retrospective chart review of all patients who underwent PPV for PDR from January 2014 to October 2016. Patients who underwent IVC injection before PPV were assigned to the IVC group; the others were assigned to the control group. The IVC was performed 3-7d before surgery in the IVC group. All the eyes in the two groups were operated by the same doctor to complete the vitrectomy. Intraoperative complications and the changes in best-corrected visual acuity (BCVA) before and after surgery were compared between the two groups. RESULTS: A total of 68 eyes of 63 patients (22 eyes in the IVC group and 46 eyes in the control group) were examined. The risk of intraoperative bleeding was lower in the IVC group (2/22) than in the control group (25/46, P=0.000). Furthermore, the use of endodiathermy was significantly lower in the IVC group (1/22) than in the control group (12/46, P=0.047). The surgical time in the IVC group (112.64±34.52min) was significantly shorter than in the control group (132.85±40.04min, P<0.05). Compared to the BCVA before surgery, the mean BCVA was significantly improved after surgery for both groups (P<0.05). CONCLUSION: PPV is an effective treatment and can improve vision in patients with PDR. Preoperative intravitreal injection of conbercept could reduce the chances of intraoperative bleeding and the use of endodiathermy and shorten the operative time, which are beneficial in the management of PDR.

12.
Cancer Cell ; 33(3): 368-385.e7, 2018 03 12.
Artigo em Inglês | MEDLINE | ID: mdl-29455928

RESUMO

Aerobic glycolysis (the Warburg effect) facilitates tumor growth, and drugs targeting aerobic glycolysis are being developed. However, how the Warburg effect is directly regulated is largely unknown. Here we show that transcription factor SIX1 directly increases the expression of many glycolytic genes, promoting the Warburg effect and tumor growth in vitro and in vivo. SIX1 regulates glycolysis through HBO1 and AIB1 histone acetyltransferases. Cancer-related SIX1 mutation increases its ability to promote aerobic glycolysis and tumor growth. SIX1 glycolytic function is directly repressed by microRNA-548a-3p, which is downregulated, inversely correlates with SIX1, and is a good predictor of prognosis in breast cancer patients. Thus, the microRNA-548a-3p/SIX1 axis strongly links aerobic glycolysis to carcinogenesis and may become a promising cancer therapeutic target.


Assuntos
Proliferação de Células/genética , Regulação Neoplásica da Expressão Gênica/genética , Glicólise/genética , Proteínas de Homeodomínio/genética , Neoplasias da Mama/genética , Neoplasias da Mama/patologia , Linhagem Celular Tumoral , Regulação para Baixo , Humanos , MicroRNAs/genética
13.
Graefes Arch Clin Exp Ophthalmol ; 255(6): 1167-1171, 2017 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-28389702

RESUMO

PURPOSE: The purpose of the study was to describe the development of a robotic aided surgical system named RVRMS (robotic vitreous retinal microsurgery system) and to evaluate the capability for using it to perform vitreoretinal surgery. METHODS: The RVRMS was designed and built to include the key components of two independent arms. End-effectors of each arm fix various surgical instruments and perform intraocular manipulation. To evaluate properly the RVRMS, robot-assisted 23-gauge surgical tasks including endolaser for retinal photocoagulation, pars plana vitrectomy (PPV), retinal foreign body removal and retinal vascular cannulation were performed in two different sizes of an animal model. Endolaser was performed in the eye of a living Irish rabbit and the other tasks were done in a harvested porcine eye. For each evaluation, the duration and the successful completion of the task was assessed. RESULTS: Robot-assisted vitreoretinal operations were successfully performed in nine rabbit eyes and 25 porcine eyes without any iatrogenic complication such as retinal tear or retinal detachment. In the task of using an endolaser, three rows of burns around the induced retinal hole were performed in nine rabbit eyes with half size intervals of laser spots. Nine procine eyes underwent PPV followed by successful posterior vitreous detachment (PVD) induction assisted with triamcinolone acetonide (TA). Nine porcine eyes completed removal of a fine stainless steel wire, which was inserted into prepared retinal tissue. Finally, retinal vascular cannulation with a piece of stainless steel wire (6mm length, 45 µm pipe diameter and one end cut to ∼30° slope) was successfully achieved in seven porcine eyes. The average duration of each procedure was 10.91±1.22 min, 11.68±2.11min, 5.90±0.46 min and 13.5±6.2 min, respectively. CONCLUSIONS: Maneuverability, accuracy and stability of robot-assisted vitreoretinal microsurgery using the RVRMS were demonstrated in this study. Wider application research of robotic surgery and improvement of a robotic system should be continued.


Assuntos
Microcirurgia/métodos , Descolamento Retiniano/cirurgia , Robótica/instrumentação , Vitrectomia/métodos , Animais , Modelos Animais de Doenças , Estudos de Viabilidade , Coelhos , Descolamento Retiniano/diagnóstico , Suínos , Resultado do Tratamento , Acuidade Visual
14.
Ophthalmic Surg Lasers Imaging Retina ; 48(2): 179-182, 2017 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-28195623

RESUMO

Endoscopic vitrectomy can uniquely circumvent anterior segment opacities and is applied to a wide spectrum of retina diseases with media opacities. However, endoscopic internal limiting membrane (ILM) peeling has not been described. The authors present one case of a retinal detachment caused by a macular hole in a pathological myopic eye combined with severe keratoleukoma. The 1-year outcome after 23-gauge endoscopic ILM peeling was good. This case report demonstrates that ILM peeling with a 23-gauge endoscope, which requires subtle and difficult macular manipulation, is feasible and effectively treats macular holes complicated with anterior segment opacities. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:179-182.].


Assuntos
Endoscopia/métodos , Miopia Degenerativa/complicações , Perfurações Retinianas/cirurgia , Acuidade Visual , Membrana Basal/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Miopia Degenerativa/diagnóstico , Perfurações Retinianas/diagnóstico , Perfurações Retinianas/etiologia , Tomografia de Coerência Óptica
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