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1.
Chin J Integr Med ; 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-31919749

RESUMO

OBJECTIVE: To evaluate the effects of a 48-week course of adefovir dipivoxil (ADV) plus Chinese medicine (CM) therapy, namely Tiaogan Jianpi Hexue () and Tiaogan Jiedu Huashi () fomulae, in hepatitis B e antigen (HBeAg)-positive Chinese patients. METHODS: A total of 605 HBeAg-positive Chinese CHB patients were screened and 590 eligible participants were randomly assigned to 2 groups in 1:1 ratio including experimental group (EG, received ADV plus CM) and control group (CG, received ADV plus CM-placebo) for 48 weeks. The major study outcomes were the rates of HBeAg and HBV-DNA loss on week 12, 24, 36, 48, respectively. Secondary endpoints including liver functions (enzymes and bilirubin readings) were evaluated every 4 weeks at the beginning of week 24, 36, and 48. Routine blood, urine, and stool analyses in addition to electrocardiogram and abdominal B scan were monitored as safety evaluations. Adverse events (AEs) were documented. RESULTS: The combination therapy demonstrated superior HBeAg loss at 48 weeks, without additional AEs. The full analysis population was 560 and 280 in each group. In the EG, population achieved HBeAg loss on week 12, 24, 36, and 48 were 25 (8.90%), 34 (12.14%), 52 (18.57%), and 83 (29.64%), respectively; the equivalent numbers in the CG were 20 (7.14%), 41 (14.64%), 54 (19.29%), and 50 (17.86%), respectively. There was a statistically significant difference between these group values on week 48 (P<0.01). No additional AEs were found in EG. Subgroup analysis suggested different outcomes among treatment patterns. CONCLUSION: Combination of CM and ADV therapy demonstrated superior HBeAg clearance compared with ADV monotherapy. The finding indicates that this combination therapy may provide an improved therapeutic effect and safety profile (ChiCTR-TRC-11001263).

2.
Zookeys ; 867: 97-121, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31402839

RESUMO

Braconid parasitoids reared from Malus sieversii and Malus domestica trees in NW China infested by Agrilus mali Matsumura (Coleoptera, Buprestidae) are illustrated and discussed. Six species were found parasitising Agrilus mali in NW China, namely, Atanycolus ivanowi (Kokujev) (Braconinae), Doryctes undulatus (Ratzeburg), Pareucorystes varinervis Tobias, Polystenus rugosus Foerster, Spathius sinicus Chao, and Spathius brevicaudis Ratzeburg (Doryctinae). All listed species are newly recorded parasitoids of Agrilus mali. Pareucorystes varinervis and Spathius brevicaudis are new records for the Chinese fauna, but Spathius brevicaudis has been recorded from Taiwan before. Both sexes of Spathius brevicaudis are redescribed here to allow inclusion in the recent revision of the Chinese Spathius species. An identification key to the six braconid parasitoids of Agrilus mali in NW China is provided.

3.
Am J Transl Res ; 9(9): 4250-4260, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28979698

RESUMO

Stachydrine (Sta), a major constituent of Leonurus japonicus Houtt, has been reported to possess numerous cardioprotective effects. In this study, we evaluated the effect of Sta on pressure overload-induced diastolic heart failure in rats and investigated the mechanisms underlying the effect. Wistar rats were randomized to transverse aortic constriction (TAC) or sham operation. After 3 days, the rats that underwent TAC were randomized to treatment for a total of four experimental groups (n=10 each group): sham operation, TAC only, TAC + telmisartan (Tel), and TAC + stachydrine (Sta). After 12 weeks, we evaluated left ventricular hypertrophy, function, and fibrosis by echocardiography, pressure-volume loop analysis, and histology. In addition, levels of fibrosis-related proteins in the heart were determined by Western blot analysis. Our results showed that Sta significantly suppressed TAC-induced cardiac hypertrophy, and TAC-induced increases in heart weight/body weight and heart weight/tibial length. In addition, Sta attenuated TAC-induced decreases in left ventricular ejection fraction and improved other hemodynamic parameters. Compared with the TAC only group, rats treated with Sta exhibited significant decreases in interstitial and perivascular fibrosis, TGF-ßR1 protein levels, and phosphorylation of Smad2/3; however, protein levels of TGF-ß1, TGF-ßR2, and Smad4 did not differ significantly between the two groups. Taken together, our results demonstrate that Sta protects against diastolic heart failure by attenuating myocardial hypertrophy and fibrosis via the TGF-ß/Smad pathway.

4.
Int J Syst Evol Microbiol ; 67(9): 3666-3675, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28857022

RESUMO

A new species of the genus Phytophthora was isolated from stream water in the subtropical forests of China during a survey of forest Phytophthora from 2011 to 2013. This new species is formally described here and named Phytophthora pseudopolonica sp. nov. This new homothallic species is distinct from other known Phytophthora species in morphology and produces nonpapillate and noncaducous sporangia with internal proliferation. Spherical hyphal swellings and thin-walled chlamydospores are abundant when the species is kept in sterile water. The P. pseudopolonica sp. nov. forms smooth oogonia with paragynous and sometimes amphigynous antheridia. The optimum growth temperature of the species is 30 °C in V8-juice agar with ß-sitosterol, yet it barely grows at 5 °C and 35 °C. Based on sequences of the internal transcribed spacer and the combined ß-tubulin and elongation factor 1α gene sequence data, isolates of the new species cluster together into a single branch and are close to Phytophthora polonicabelonging to clade 9.


Assuntos
Florestas , Filogenia , Phytophthora/classificação , Rios/microbiologia , China , DNA Espaçador Ribossômico/genética , Fator 1 de Elongação de Peptídeos/genética , Phytophthora/genética , Phytophthora/isolamento & purificação , Análise de Sequência de DNA , Tubulina (Proteína)/genética
5.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 25(3): 772-776, 2017 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-28641633

RESUMO

OBJECTIVE: To investigate the clinical significance of peripheral blood NK cell number change in patients with mantle cell lymphoma. METHODS: Eight-four patients with mantle cell lymphoma treated in our hospital from November 2003 to November 2011 were studied, the venous blood was collected from all patients and detected with flow cytometry. The age, sex, pathologic type, B-symptoms, clinical stage, absolute NK count(ANKC), hemoglobin(Hb), lactate dehydrogenase(LDH) and ß2-microglobulin(ß2-MG) levels, bone marrow involuement(BMI) and the international prognostic index of mantle cell lymphoma(MIPI) were recorded. All patients were followed up. RESULTS: There were no significant differences in ANKC among different age, sex, B symptom, Ann Arbor stages, Hb, LDH and ß2-MG levels, BMI and MIPI of patients with MCL(P>0.05). The sensitivity and specificity of ANKC were 76.6% and 73.8%, respectively. The optimal throshold of ANKC was 0.10×109/L and AUC was 0.798(95% CI: 0.689-0.902)(P<0.01). The 3 year-PFS rate in patients with ANKC≥0.10×109/L was higher than that in patients with ANKC<0.10×109/L(68.2% vs 32.10%)(P<0.01). The 3 year-OS rate in patients with ANKC≥0.10×109/L was significantly higher than that in patients with ANKC<0.10×109/L (85.1% vs 43.8%)(P<0.01). Multivariate analysis showed that the independent predictors of PFS and OS in patients with MCL were ANKC and MIPI(P<0.05). CONCLUSION: The ANKC in peripheral blood has an important value for judging the prognosis of patients with MCL and can be used as an important index to judge the disease status of patients with MCL.


Assuntos
Células Matadoras Naturais , Linfoma de Célula do Manto/patologia , Medula Óssea , Contagem de Células , Humanos , Análise Multivariada , Prognóstico
6.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 23(2): 517-21, 2015 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-25948216

RESUMO

OBJECTIVE: To investigate the effects of mannan-binding lectin (MBL) on the maturation and cytokine secretion of human dendritic cells (DC) induced by Candida albicans (C. albicans). METHODS: The plastic-adherent mononuclear cells were prepared from the blood of healthy adult volunteers. The human peripheral blood mononuclear cells-derived dendritic cells (MNC-DC) were induced by 5-day-culture in medium supplemented with rhGM-CSF and rhIL-4, and then cultured for 2 days in presence or absence of C. albicans at varying concentration of human MBL ranging from 1 to 20 mg/L. DC's shape and characters were observed under inverted microscopy, the expression of CD83 and CD86 on DC was analyzed by FACS. The levels of TNF-α and IL-6 were detected by ELISA. FACS also was used to investigate the interaction of MBL with immature DC(imDC) and C. albicans. Western blot was used to detect C. albicans-induced IκBα phosphorylation and p65/NF-κB translocation in DC. RESULTS: MBL at higher concentrations (10-20 mg/L) down-regulated the expression of CD83 and CD86 on the monocyte-derived dentritic cells(MoDC) induced by C. albicans, and inhibited the production of TNF-α and IL-6 induced by C. albicans. FACS showed that MBL could not only bind to C. albicans but also bind to imDCs in a Ca2+-dependent manner. Western blot showed that MBL could decrease the phosphorylation of IκBα and the nuclear translocation of p65/ NF-κB. CONCLUSION: MBL may inhibit TNF-α and IL-6 production induced by C. albicans in DC through NF-κB signaling pathways, suggesting that MBL can play some roles in the regulation of C. albicans-induced immune response.


Assuntos
Candida albicans , Células Dendríticas , Diferenciação Celular , Citocinas , Humanos , Lectina de Ligação a Manose , NF-kappa B , Transporte Proteico
7.
Int J Clin Exp Pathol ; 8(11): 14812-7, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26823809

RESUMO

OBJECTIVE: To analyze the plasmatic ADM level in early pregnancy and to investigate the diagnostic value of ADM in early ectopic pregnancy (EP). METHODS: 70 patients with EP who had menopause for 5~8 weeks were included as study group, while 155 women with normal intrauterine pregnancy were also included as control group. The correlation between ADM level and menopause weeks was statistically analyzed and ROC curve was used to identify the diagnostic value of ADM. RESULTS: (1) In 155 cases of normal intrauterine pregnancy, the plasmatic ADM level was increased with menopause weeks in linear relationship, and the correlation coefficient (R) was 0.991 (P<0.05). In 70 patients with EP, no significant increase was found with menopause weeks and no linear relationship can be found between ADM level and menopause weeks in EP group. The correlation coefficient (R) was 0.744 (P>0.05). (2) The multiple of median of plasmatic ADM level in EP group of menopause for 8 weeks was obviously lower than the intrauterine control group (P<0.01). (3) ROC curve was used to analyze the cut-off value of ADM level in the diagnosis of EP, and the area under the ROC curve was 0.523 (P>0.05) regardless of menopause weeks, however, the area under the ROC curve was 0.702 (P<0.05) at 8 weeks after menopause with sensitivity of 53.50% and specificity of 85.00%. CONCLUSIONS: Different from normal intrauterine pregnancy, plasmatic ADM level in early EP was relatively lower and no significant increase was found with menopause weeks; further studies are still needed for plasmatic ADM level as an indicator in the early diagnosis of EP.


Assuntos
Adrenomedulina/sangue , Biomarcadores/sangue , Gravidez Ectópica/sangue , Gravidez Ectópica/diagnóstico , Adulto , Área Sob a Curva , Diagnóstico Precoce , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Gravidez , Curva ROC , Sensibilidade e Especificidade
8.
Zhonghua Fu Chan Ke Za Zhi ; 48(3): 177-9, 2013 Mar.
Artigo em Chinês | MEDLINE | ID: mdl-23849938

RESUMO

OBJECTIVE: To study the value of hCG ratio of blood in peritoneal cavity versus venous blood (RPhCG/VhCG) in diagnosis of early ectopic pregnancy (EP). METHODS: From Mar. 2009 to Oct. 2012, 268 cases with EP (EP group) and 53 women with intrauterine pregnancy with haemoperitoneum (hIUP) (hIUP group) from International Peace Maternity and Child Health Hospital of Shanghai Jiaotong University School of Medicine, Shanghai 6th People Hospital and Shanghai Jiangwan Hospital were enrolled in this prospective study. The HCG of all subjective were measured in blood in peritonea cavity and venous blood, then calculate the ratio of RPhCG/VhCG. Scatter point analysis and ROC were used to differentiate EP, determine threshold of hIUP and evaluate the sensitivity, specificity and accuracy in diagnosis EP preoperatively. RESULTS: The mean RPhCG/VhCG of EP group was 4.35, which was significantly higher than 0.81 in hIUP group (P < 0.01). Scatter point analysis showed that the threshold value of RPhCG/VhCG between ectopic pregnancy and hIUP was 1.0. The overall sensitivity of RPhCG/VhCG in the diagnosis of EP was 98%, the specificity was 100%, the positive predictive value was 100% and the negtive predictive value was 93%. CONCLUSION: RPhCG/VhCG > 1.0 could be used to diagnose and differentiate EP from hIUP accurately.


Assuntos
Gonadotropina Coriônica/sangue , Hemoperitônio/diagnóstico , Gravidez Ectópica/sangue , Gravidez Ectópica/diagnóstico , Adulto , Biomarcadores/sangue , Estudos de Casos e Controles , Diagnóstico Diferencial , Diagnóstico Precoce , Feminino , Hemoperitônio/metabolismo , Humanos , Valor Preditivo dos Testes , Gravidez , Estudos Prospectivos , Curva ROC , Sensibilidade e Especificidade
9.
Cell Biol Toxicol ; 29(4): 229-38, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23812630

RESUMO

We investigated mitogen-activated protein kinase (MAPK) pathways as well as reactive oxygen species (ROS) in olaquindox-induced apoptosis. Exposure of HepG2 cells to olaquindox resulted in the phosphorylation of p38 MAPK and c-Jun N-terminal kinases (JNK). To confirm the role of p38 MAPK and JNK, HepG2 cells were pretreated with MAPKs-specific inhibitors prior to olaquindox treatment. Olaquindox-induced apoptosis was significantly potentiated by the JNK inhibitor (SP600125) or the p38 MAPK inhibitor (SB203580). Furthermore, we observed that olaquindox treatment led to ROS generation and that olaquindox-induced apoptosis and ROS generation were both significantly reduced by the antioxidants, superoxide dismutase and catalase. In addition, the levels of phosphorylation of JNK, but not p38 MAPK, were significantly suppressed after pretreatment of the antioxidants, while inhibition of the activations of JNK or p38 MAPK had no effect on ROS generation. This result suggested that ROS may be the upstream mediator for the activation of JNK. Conclusively, our results suggested that apoptosis in response to olaquindox treatment in HepG2 cells might be suppressed through p38 MAPK and ROS-JNK pathways.


Assuntos
Apoptose/efeitos dos fármacos , Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo , Quinoxalinas/farmacologia , Espécies Reativas de Oxigênio/metabolismo , Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo , Antracenos/farmacologia , Catalase/metabolismo , Linhagem Celular Tumoral , Inibidores Enzimáticos/farmacologia , Células Hep G2 , Humanos , Imidazóis/farmacologia , Proteínas Quinases JNK Ativadas por Mitógeno/antagonistas & inibidores , Sistema de Sinalização das MAP Quinases/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Fosforilação , Piridinas/farmacologia , Superóxido Dismutase/metabolismo , Proteínas Quinases p38 Ativadas por Mitógeno/antagonistas & inibidores
10.
Sci Rep ; 3: 1181, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-23383368

RESUMO

Hierarchical alloy nanosheet dendrites (ANSDs) are highly favorable for superior catalytic performance and efficient utilization of catalyst because of the special characteristics of alloys, nanosheets, and dendritic nanostructures. In this paper, we demonstrate for the first time a facile and efficient electrodeposition approach for the controllable synthesis of Pd-Sn ANSDs with high surface area. These synthesized Pd-Sn ANSDs exhibit high electrocatalytic activity and superior long-term cycle stability toward ethanol oxidation in alkaline media. The enhanced electrocataytic activity of Pd-Sn ANSDs may be attributed to Pd-Sn alloys, nanosheet dendrite induced promotional effect, large number of active sites on dendrite surface, large surface area, and good electrical contact with the base electrode. Because of the simple implement and high flexibility, the proposed approach can be considered as a general and powerful strategy to synthesize the alloy electrocatalysts with high surface areas and open dendritic nanostructures.

11.
J Am Chem Soc ; 134(13): 5730-3, 2012 Apr 04.
Artigo em Inglês | MEDLINE | ID: mdl-22404702

RESUMO

Porous Pt-Ni-P composite nanotube arrays (NTAs) on a conductive substrate in good solid contact are successfully synthesized via template-assisted electrodeposition and show high electrochemical activity and long-term stability for methanol electrooxidation. Hollow nanotubular structures, porous nanostructures, and synergistic electronic effects of various elements contribute to the high electrocatalytic performance of porous Pt-Ni-P composite NTA electrocatalysts.

12.
Mol Cell Biochem ; 354(1-2): 253-61, 2011 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-21598074

RESUMO

Olaquindox, a synthetic antimicrobial compound, was banned as feed additives in the U.S. and the EU. In China, the use of olaquindox is banned in poultry and aquaculture feed, restricted in livestock feed for growth promotion. Olaquindox's safety is the object of increasing attention. The present study was undertaken to investigate whether and how olaquindox elevates expression of c-Myc, which influences olaquindox-induced apoptosis in HepG2 cells. For a better understanding of c-Myc's role in susceptibility of human hepatoma G2 cells to olaquindox-induced apoptosis, two vectors (the pSilencer-cmyc(Si-cmyc) and the control vector) were transfected to HepG2 cells. The cells were pretreated with Si-cmyc, which expressed only 35-65% c-Myc protein levels compared to those of the parental cells and the control cells. We examined effects of olaquindox on reactive oxygen species (ROS) production in these c-Myc low-expressing cells, and on apoptosis. Our data revealed that ROS production induced by olaquindox treatment was partially blocked by Si-cmyc transfection and partly inhibited olaquindox-induced apoptosis through decreased ROS generation. Further data showed that olaquindox induced decreased ROS by Si-cmyc transfection through decreased cytochrome c release to cytosol, which inhibited apoptosis of the cells. These results suggest that c-Myc might be important during olaquindox-induced apoptosis in human hepatoma G2 cells.


Assuntos
Apoptose , Substâncias de Crescimento/farmacologia , Proteínas Proto-Oncogênicas c-myc/metabolismo , Quinoxalinas/farmacologia , Carcinoma Hepatocelular , Linhagem Celular Tumoral , Sobrevivência Celular , Citocromos c/metabolismo , Humanos , Proteínas Proto-Oncogênicas c-myc/genética , Interferência de RNA , Espécies Reativas de Oxigênio , Transcrição Genética , Regulação para Cima
13.
Artigo em Chinês | MEDLINE | ID: mdl-22734241

RESUMO

OBJECTIVE: To study the clinical efficacy of PEG Interferon alpha-2a combined with ribavirin in treatment of with hepatitis C cirrhosis patients. METHODS: 21 patients with chronic hepatitis C cirrhosis (treated group) ,were treated with peg-IFNalpha-2a 135 -180 microg subcutaneously, 1 week,ribavirin tablets 800 -1000 mg/d,48 weeks of treatment and follow-up 24 weeks, 20 patients with Chronic hepatitis C (control group), were treated with peg-IFNalpha-2a 135 -180 microg subcutaneously, 1 week,ribavirin tablets 600 -1000 mg/d, 48 weeks of treatment, follow-up 24 weeks, comparison of rapid virological response (RVR) rates, early virologic response (EVR) rate, sustained virologic response (SVR) rate, adverse reactions was observed. RESULTS: The differences of RVR, EVR, ETVR in two groups is not significant, but SVR in treatment group was lower (P < 0.05), and has a higher incidence bone marrow suppression and anemia (P < 0.05). Flu-like symptoms, hair loss, gastrointestinal reactions and other adverse reactions was no significant difference between the two groups. CONCLUSION: The use of 135 microg peg-IFNalpha-2a and individual in low-dose ribavirin hepatitis C patients with cirrhosis is more security,could get a good early response, but sustained virologic response (SVR) rates is lower than hepatitis C patients. Blood, liver and kidney function should be closely observed during treatment process.


Assuntos
Hepatite C Crônica/tratamento farmacológico , Interferon-alfa/administração & dosagem , Cirrose Hepática/tratamento farmacológico , Polietilenoglicóis/administração & dosagem , Ribavirina/administração & dosagem , Adulto , Quimioterapia Combinada , Feminino , Hepatite C Crônica/virologia , Humanos , Interferon-alfa/efeitos adversos , Cirrose Hepática/virologia , Masculino , Pessoa de Meia-Idade , Polietilenoglicóis/efeitos adversos , Proteínas Recombinantes/administração & dosagem , Proteínas Recombinantes/efeitos adversos , Ribavirina/efeitos adversos
14.
Inorg Chem ; 49(4): 1679-86, 2010 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-20063879

RESUMO

Hierarchical SnO(2) microspheres consisting of nanosheets on the fluorine-doped tin oxide (FTO) glass substrates are successfully prepared via a facile hydrothermal synthesis process. The as-prepared novel microsphere films were characterized in detail by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), UV-vis diffuse reflectance spectroscopy. Moreover, SnO(2) nanoparticles with 30-80 nm in size covered on the surface of nanosheets/microspheres were also obtained by optimizing the hydrothermal reaction temperature, time, or volume ratio of acetylacetone/H(2)O. The detailed investigations disclose the experimental parameters, such as acetylacetone, NH(4)F, and seed layer play important roles in the morphology of hierarchical SnO(2) microspheres on the FTO glass. The formation process of SnO(2) microspheres is also proposed based on the observations of time dependent samples.


Assuntos
Fluoretos/química , Microscopia Eletrônica de Transmissão/métodos , Microesferas , Compostos de Estanho/química , Estanho/química , Vidro/química , Óxidos/química , Fotoquímica , Propriedades de Superfície , Óxido de Zinco/química
15.
Zhongguo Zhong Xi Yi Jie He Za Zhi ; 30(12): 1269-71, 2010 Dec.
Artigo em Chinês | MEDLINE | ID: mdl-21302488

RESUMO

OBJECTIVE: To investigate the distribution of somato-types in Chinese medicine and its correlations with body mass index (BMI), blood lipids and hepato-enzymes in patients with non-alcoholic fatty liver disease (NAFLD). METHODS: From January 2008 to December 2008, the somato-types of 1 163 NAFLD patients were categorized, and its correlations with BMI, blood lipids and hepato-enzymes were analyzed. RESULTS: Among the 1 163 patients, 401 were categorized as qi-deficiency type and 371 as phlegm-dampness type, accounting for 66.38%. Levels of BMI, blood lipids (TC, TG, LDL) and hepato-enzymes (ALT, AST, GGT) in patients of phlegm-dampness type were higher than those in patients of other types, the differences were statistically significant (P<0.05). CONCLUSIONS: Qi-deficiency type and phlegm-dampness type are the dominant pathogenetic somsto-types in patients with NAFLD; abnormal BMI, blood lipids and hepato-enzymes may present in those of phlegm-dampness type more frequently.


Assuntos
Índice de Massa Corporal , Fígado Gorduroso/metabolismo , Lipídeos/sangue , Fígado/fisiopatologia , Medicina Tradicional Chinesa , Adulto , Idoso , Alanina Transaminase/sangue , Aspartato Aminotransferases/sangue , Diagnóstico Diferencial , Fígado Gorduroso/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Hepatopatia Gordurosa não Alcoólica , Qi , Deficiência da Energia Yang/metabolismo , Deficiência da Energia Yang/fisiopatologia , Adulto Jovem
17.
Zhong Xi Yi Jie He Xue Bao ; 3(4): 290-3, 2005 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-16009109

RESUMO

OBJECTIVE: To observe the effects of Huatan Xiezhuo Recipe (HTXZR) on fatty liver of rats. METHODS: Forty-eight SD rats were randomly divided into five groups: normal control group, untreated group, Dongbao Gantai Tablet (DBGTT)-treated group, low-dose HTXZR-treated group and high-dose HTXZR-treated group. Fatty liver was induced in the rats by hyperlipid diet and intraperitoneal injection of tetracycline. The pathological changes of liver tissues in rats were observed, and the liver function, serum leptin, insulin resistance index, triglyceride (TG) and free fatty acid (FFA) in the liver were detected. RESULTS: The levels of serum leptin, insulin resistance index, FFA and TG in rats of the three treated groups were lower than those of the untreated group (P<0.01), and such effects in the HTXZR-treated groups were more significant than those in the DBGTT-treated group (P<0.05). CONCLUSION: The main action mechanisms of HTXZR in treating fatty liver are probably to promote the lipid metabolism, decrease the leptin and insulin resistance.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Fígado Gorduroso/tratamento farmacológico , Resistência à Insulina , Leptina/sangue , Fitoterapia , Animais , Ácidos Graxos não Esterificados/sangue , Fígado Gorduroso/metabolismo , Masculino , Distribuição Aleatória , Ratos , Ratos Sprague-Dawley
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