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1.
Carbohydr Polym ; 276: 118728, 2022 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-34823764

RESUMO

The coexistence of anionic and cationic dyes in dye wastewater has highlighted a great necessity to develop amphoteric adsorbents for their simultaneous removal. Herein, an amphoteric composite sponge was successfully fabricated by combining chitosan with electrospun sodium alginate nanofiber using lyophilization in acetic acid/water/dioxane mixed solvents, which owned the abundant functional groups and superior microstructure of interconnected pores and nanoscale fibers, beneficial for the adsorption capacity improvement. The optimum adsorption capacities for Acid Blue-113 and Rhodamine B were 926.2 ± 25.7 mg/g and 695.4 ± 17.0 mg/g, respectively, much higher than that of the controlled sample prepared with chitosan and non-spinning sodium alginate in traditional acetic acid/water solvents. Meanwhile, the sponge provided with the superior adsorption performance under various pH environment and cyclic adsorption. Importantly, it had considerable simultaneous adsorption capacity for binary system containing anionic and cationic dyes. Overall, the chitosan/electrospun sodium alginate nanofiber composite sponge shows potential for complex wastewater treatment.

2.
Sci Total Environ ; 806(Pt 3): 151213, 2022 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-34715221

RESUMO

Oxygen permeable membrane, which has the advantages of high separation selectivity, low energy consumption and simple process in oxygen separation, can be used in the fields of environment and energy, such as pure oxygen preparation, fuel cell, oxygen-enriched combustion and chemical reactor for methane catalytic conversion (e.g. partial oxidation of methane, carbon dioxide reforming with methane). New materials and technological development are needed to achieve this target for GHG reformation. In this direction, mixed ionic-electronic conducting (MIEC) oxides based on perovskite oxides are one of the prominent materials for oxygen transport at high temperatures. These compounds were created into solid ceramic membranes with considerable electronic and oxygen ionic conductivity. As a result of the differential partial pressure of oxygen across the membrane, this process enables the ionic transfer of oxygen from the air, providing the driving force for oxygen ion transport. Notably, over the last 40 years, the defect theory has been applied to a wide range of MIEC materials, providing insight into electronic and ionic transport, widely applied to designing catalysts for wastewater treatment and gas purification. However, a critical review by in-depth analysis from the material side on perovskite oxides for oxygen transport is needed. This work evaluates the research community's significant and relevant contributions in the perovskite oxides for gas separation domain over the previous four decades in conjunction with theoretical concepts, which would give rise to the fundamental understanding of the impact of various transitional metal elements on oxygen transport performance and stability in a different atmosphere.

3.
Behav Brain Res ; 417: 113618, 2022 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-34610370

RESUMO

Acute stress triggers a complex cascade of psychological, physiological, and neural responses, which show large and enduring individual differences. Although previous studies have examined the relationship between the stress response and dynamic features of the brain's resting state, no study has used the brain's dynamic activity in the resting state to predict individual differences in the psychosocial stress response. In the current study, resting-state scans of forty-eight healthy participants were collected, and then their individual acute stress responses during the Montreal Imaging Stress Test (MIST) paradigm were recorded. Results defined a connectivity state (CS) characterized by positive correlations across the whole brain during resting-state that could negatively predict participants' feelings of social evaluative threat during stress tasks. Another CS characterized by negative correlations between the frontal-parietal network (FPN) and almost all other networks, except the dorsal attentional network (DAN), could predict participants' subjective stress, feelings of uncontrollability, and feelings of social evaluative threat. However, no CS could predict participants' salivary cortisol stress response. Overall, these results suggested that the brain state characterized as attentional regulation, linking self-control, and top-down regulation ability, could predict the psychosocial stress response. This study also developed an objective indicator for predicting human stress responses.

4.
New Phytol ; 2021 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-34812499

RESUMO

The development of viable pollen determines male fertility, and is crucial for reproduction in flowering plants. Phytochrome-Interacting Factor 3 (PIF3) acts as a central regulator of plant growth and development, but its relationship with pollen development has not been determined. Through genetic, histological and transcriptomic analyses, we identified an essential role for SlPIF3 in regulating tomato (Solanum lycopersicum) pollen development. Knocking out SlPIF3 using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 resulted in pollen mitosis I (PMI) arrest, and a failure to form viable pollen. We further demonstrated that both glutamate synthase 1 (SlGLT1) and cell wall invertase 9 (SlCWIN9), involved in auxin and sugar homeostasis, respectively, colocalized with SlPIF3 in the anthers and were directly regulated by SlPIF3. Knockout of either SlGLT1 or SlCWIN9 phenocopied the pollen phenotype of SlPIF3 knockout (Slpif3) lines. Slpif3 fertility was partially restored by exogenous auxin (IAA) in a dose-dependent manner. This study reveals a mechanism by which SlPIF3 regulates pollen development and highlights a new strategy for creating hormone-regulated genic male-sterile lines for tomato hybrid seed production.

5.
Mater Horiz ; 8(6): 1825-1834, 2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-34846511

RESUMO

Metal-organic electrode materials have exhibited extraordinary promise for green and sustainable electrochemical energy storage devices, but usually suffer from low specific capacity, and poor cycling stability and rate capability because of limited active sites at organic functional groups. To address this issue, activating transition metals and carbon conjugate rings has become significantly effective to make transferred electrons dispersed in the whole molecule. In this work, we demonstrate that assembling inorganic-organic building blocks into "local" composite metal-organic materials could synergistically activate transition metal ions and carbon conjugate rings to operate cationic and anionic redox, respectively. Based on first-principles calculations, the composite inorganic-organic material FeF3(4,4'-bpy) generates 8-electron transfer redox processes of Fe3+ + 2e-→ Fe+ and 2 -C[double bond, length as m-dash]N- + 2e-→ 2 (-C-N-)- and 4 -C[double bond, length as m-dash]C- + 4e-→ 4 (-C-C-)-, achieving a high specific capacity of 796.7 mA h g-1, maintaining structural stability, and reducing the band gap. The strongly electronegative F-ions in inorganic structure [FeF4]2- play an important role in making highly oxidized Fe3+ through forming a strong ligand field and electrochemically activating -C[double bond, length as m-dash]C-via electrostatic interaction with Li+. In addition, electrochemical measurements also reveal that the central metal Fe, and -C[double bond, length as m-dash]C and -C[double bond, length as m-dash]N bonds of the FeF3(4,4'-bpy) electrode are the active sites for Li-ion storage to deliver a high reversible capacity (793.1 mA h g-1 at 50 mA g-1) and excellent rate capability, which are echoes of the DFT calculations. Through this design principle, we found a series of high-capacity metal organic electrode materials such as MnF3(4,4'-bpy) (799.6 mA h g-1) and VF3(4,4'-bpy) (811.7 mA h g-1).

6.
Brain Behav ; 11(10): e2233, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34520625

RESUMO

INTRODUCTION: Prenatal stress (PS) can cause depression in offspring. However, the underlying biological mechanism of these influences is still unclear. This work was implemented to investigate the molecular mechanisms of depressive-like behavior of offspring rats insulted with PS. METHODS: Relative quantitative phosphoproteomics of the hippocampus of PS susceptibility (PS-S) and control (CON) rat offspring was performed using liquid chromatography-tandem mass spectrometry to confirm known pathways and to identify new mechanisms involved in depression. RESULTS: A total of 6790 phosphopeptides, 9817 phosphorylation sites, and 2978 phosphoproteins were detected. Among the 2978 phosphoproteins, 1760 (59.09%) had more than two phosphorylated sites, the ENSRNOP00000023460 protein had more than 117 phosphorylated sites, and the average distribution of modification sites per 100 amino acids was 2.97. There were 197 different phosphopeptides, including 140 increased phosphopeptides and 57 decreased phosphopeptides in the PS-S offspring rats, compared to the CON offspring rats. These differential phosphopeptides corresponded to 100 upregulated and 44 downregulated phosphoproteins, respectively. Gene ontology enrichment analysis revealed that these different phosphoproteins in the top five enriched terms in the cellular component, molecular function, and biological proces categories were involved in a total of 35 different phosphoproteins, and these phosphoproteins were mainly related to myelin-, microtubule- and synapse-associated proteins. The enrichment of Kyoto Encyclopedia of Genes and Genome pathways was found to be involved in many essential biological pathways, and the top five pathways included amphetamine addiction, insulin secretion, Cushing syndrome, and the circadian entrainment signaling pathway. These first five pathways were related to nine phosphoproteins, including Adcy9, Apc, Cacna1c, Camk2a, Camk2b, Camk2g, Ctnnd2, Grin2a, and Stx1a. The full data are available via ProteomeXchange with identifier PXD019117. CONCLUSION: We preliminarily identified 144 different phosphoproteins involved in myelin, microtubule, and synapse formation and plasticity in the hippocampus of susceptible offspring rats exposed to PS.

7.
Adv Mater ; 33(44): e2104039, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34477273

RESUMO

Organic electrode materials have shown extraordinary promise for green and sustainable electrochemical energy storage devices, but usually suffer from low specific capacity and poor rate capability, which is largely caused by inactive components and diffusion-controlled Li+ intercalation. Herein, high-rate Li+ intercalation pseudocapacitance in organic molecular crystals is achieved through introducing weak secondary bonding channels, far exceeding their theoretical capacity based on redox chemistry at functional groups. The authors' combined experimentally electrochemical characterization with first-principles calculations show that the heterocyclic organic molecule 2,2'-bipyridine-4,4'-dicarboxylic acid (BPDCA) crystal permits a four-electron redox reaction at conventional CO and CN groups and a six-electron intercalation pseudocapacitance along conjugated alkene hydrogen bonding channels (H2 NC5 H⋯OC(OH)) and heterocyclic aromatic stacking channels (C5 H3 N⋯NH3 C5 ). The BPDCA electrode delivers an ultrahigh reversible capacity of 1206 mAh g-1 at 0.5 A g-1 and an exceptional rate capability. A 4.8 V high-energy/power-density BPDCA anode-based hybrid Li-ion capacitor is thus realized. This work opens a new avenue for developing organic intercalation pseudocapacitive materials via secondary bonding structure design.

8.
J Healthc Eng ; 2021: 1322397, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34336148

RESUMO

Objective: To study and analyze the changes of intervertebral foramen height and area of the degenerative L4-5 intervertebral disc under different pushing heights by the finite element method. Methods: CT and MRI images of T12-S1 segments were obtained from a healthy volunteer who met the inclusion criteria. A DR machine was used to capture images of the lumbar lateral section before and after simultaneous pushing of the L4 and L5 spinous processes by manipulation called Daogaijinbei, and the measurement showed that the displacement changes of L4 and L5 were both approximately 10 cm, so the pushing height was set at 0-10 cm. A three-dimensional finite element model of the entire normal lumbar spine was established using Mimics 16.0, Geomagic Studio 2014, Hypermesh 13.0, MSC.Patran 2012, and so on. The disc height and nucleus area of the lumbar disc of the normal entire lumbar disc model were adjusted to establish models of the L4-5 disc with mild, moderate, and severe degeneration. Changes of disc height and area of the L4-5 degenerative intervertebral disc under different pushing heights were calculated. Results: The size of the L4-5 intervertebral foramen was analyzed from the height and area of the intervertebral foramen, and the results showed the following: (1) as for the normal lumbar disc and a lumbar of the L4-5 disc with mild and moderate degeneration, the height of the L4-5 intervertebral foramen and its area both increased during pushing between 0 and 8 cm. After the pushing height reached 8 cm, the height and area of the L4-5 intervertebral foramen gradually became stable; (2) as for the L4-5 disc with severe degeneration, during the process of pushing, the height and area of the L4-5 intervertebral foramen increased slightly, but this change was not obvious. Conclusions: After the spinal manipulation, the sizes of the L4-5 intervertebral foramen of the L4-5 disc with mild and moderate degeneration were significantly larger than those before pushing; in contrast, the size of L4-5 intervertebral foramen of the L4-5 disc with severe lumbar degeneration was not significantly changed.


Assuntos
Degeneração do Disco Intervertebral , Disco Intervertebral , Análise de Elementos Finitos , Humanos , Disco Intervertebral/diagnóstico por imagem , Degeneração do Disco Intervertebral/diagnóstico por imagem , Vértebras Lombares/diagnóstico por imagem , Tração
9.
Psychophysiology ; 58(10): e13892, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34216019

RESUMO

Recent studies suggest that reward anticipation decreases individuals' acute stress responses. However, individuals who have experienced early life stress (ELS) may have a blunted capacity for reward anticipation, which reduces its buffering effect on psychosocial stress responses. To investigate this phenomenon, 66 young adults completed the Trier Social Stress Test following a reward anticipation task, and their ELS levels were measured using the Childhood Trauma Questionnaire (CTQ). Meanwhile, the current study collected biological and psychological measures of stress by analysing cortisol levels, heart rates, heart rate variability (HRV) as well as subjective stress levels, in response to the Trier Social Stress test. Results showed that reward anticipation successfully decreased acute stress responses in general, and it also improved participants' HRV. However, this effect was more evident in individuals with low ELS than those with high ELS. These findings help us deepen understanding of the role of reward anticipation in fostering resilience under stress and the potentially important implications for individuals who have been exposed to ELS are also discussed.

10.
Plant Dis ; 2021 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-33970031

RESUMO

In September 2020, a disease resembling stem blight on soybean was found in Chengdu city, Sichuan province, southwestern of China. Symptoms began as a brown lesion on the stems, usually at the nodes, then lesions expanded, darkened, and even girdled the stems, causing wilt of the above stems (Figure 1A). In three 0.33-ha fields, a total of 300 soybean plants (20 plants/site × 5 sites/filed × 3 fields) were investigated, and 3% of the plants showed the disease symptoms. The symptoms were consistent with those previously reported for stem canker and stem blight on soybean caused by Diaporthe complex (Cui et al. 2009; Mena et al. 2019; Santos et al. 2011). The tissues of symptomatic soybean stems were rinsed by water, disinfected by submerging them in 75% ethanol for 30 s and in 2% sodium hypochlorite solution for 2 min, then followed by washing with sterile distilled water. Small diseased tissue fragments were placed on selective potato dextrose agar (PDA) containing rifampicin and ampicillin (both 50 mg/µl). Plates were sealed and incubated at 26°C for two days. Developing mycelia of isolates were transferred to fresh PDA and purified by single hyphal tip. For the five obtained isolates (Figure 1B), five markers, including the internal transcribed spacer (ITS) region of the nuclear ribosomal DNA, parts of the translation elongation factor 1-α (TEF1), part of the histone H3 (HIS) gene, the calmodulin gene (CAL), and the beta-tubulin gene (TUB), were amplified using the established primers ITS4/ITS5 (White et al. 1990), EF1-728F/EF1-986R (Carbone and Kohn 1999), CYLH3F (Crous et al. 2006) and H3-1b (Glass and Donaldson 1995), CAL228F/CAL737R (Carbone and Kohn 1999), and Bt-2a/Bt-2b (Glass and Donaldson 1995), respectively, and sequenced (GenBank IDs: MW595761-MW595780 and MW624472-MW624476). Phylogenetic trees were constructed based on concatenated sequences of the five markers using the maximum-likelihood (ML) method in MEGA-5.2.2. Based the results of morphological (Figure 1C-E) and phylogenetic analysis (Figure 2), the five isolates were all identified as D. phaseolorum. Pathogenicity tests for the isolates were conducted on 7-day-old soybean seedlings (cv. Shangdou 1310) using a hypocotyl slit inoculation method. At the stem 2-cm below cotyledon, a 6-mm long slit was cut with a sterile scalpel, and placed inside with a 3 mm × 3 mm PDA plug with or without mycelia of pathogen. Ten plants were assayed for each treatment, and the plants were maintained in greenhouse at 26°C, with humidity higher than 90% for the first two days. The assay was repeated at least three times. Typical brown lesions on the stems were observed four days after inoculation (Figure 1F), even 20% treated plants died. The D. phaseolorum was reisolated from these stem lesions. No disease symptom was observed on control plants (Figure 1G). Thus D. phaseolorum was the pathogen causing the soybean stem blight in field. To our knowledge, this is the first report of D. phaseolorum causing this disease in Sichuan province, China. The result may provide useful information for soybean disease control in this region of China. The authors declare no conflict of interest. Funding: China Agriculture Research System (CARS-004-PS14).

11.
Bioact Mater ; 6(12): 4415-4429, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33997517

RESUMO

Cell therapy has been a promising strategy for cardiac repair after myocardial infarction (MI), but a poor ischemic environment and low cell delivery efficiency remain significant challenges. The spleen serves as a hematopoietic stem cell niche and secretes cardioprotective factors after MI, but it is unclear whether it could be used for human pluripotent stem cell (hiPSC) cultivation and provide a proper microenvironment for cell grafts against the ischemic environment. Herein, we developed a splenic extracellular matrix derived thermoresponsive hydrogel (SpGel). Proteomics analysis indicated that SpGel is enriched with proteins known to modulate the Wnt signaling pathway, cell-substrate adhesion, cardiac muscle contraction and oxidation-reduction processes. In vitro studies demonstrated that hiPSCs could be efficiently induced into endothelial cells (iECs) and cardiomyocytes (iCMs) with enhanced function on SpGel. The cytoprotective effect of SpGel on iECs/iCMs against oxidative stress damage was also proven. Furthermore, in vivo studies revealed that iEC/iCM-laden SpGel improved cardiac function and inhibited cardiac fibrosis of infarcted hearts by improving cell survival, revascularization and remuscularization. In conclusion, we successfully established a novel platform for the efficient generation and delivery of autologous cell grafts, which could be a promising clinical therapeutic strategy for cardiac repair and regeneration after MI.

12.
Soc Cogn Affect Neurosci ; 16(7): 726-735, 2021 07 06.
Artigo em Inglês | MEDLINE | ID: mdl-33949671

RESUMO

Relational self-esteem (RSE) refers to one's sense of self-worth based on the relationship with significant others, such as family and best friends. Although previous neuroimaging research has investigated the neural processes of RSE, it is less clear how RSE is represented in multivariable neural patterns. Being able to identify a stable RSE signature could contribute to knowledge about relational self-worth. Here, using multivariate pattern classification to differentiate RSE from personal self-esteem (PSE), which pertains to self-worth derived from personal attributes, we obtained a stable diagnostic signature of RSE relative to PSE. We found that multivariable neural activities in the superior/middle temporal gyrus, precuneus, posterior cingulate cortex, dorsal medial Prefrontal Cortex (dmPFC) and temporo-parietal junction were responsible for diagnosis of RSE, suggesting that the evaluation of RSE involves the retrieval of relational episodic memory, perspective-taking and value calculation. Further, these diagnostic neural signatures were able to sensitively decode neural activities related to RSE in another independent test sample, indicating the reliability of the brain state represented. By providing a reliable multivariate brain pattern for RSE relative to PSE, our results informed more cognitively prominent processing of RSE than that of PSE and enriched our knowledge about how relational self-worth is generated in the brain.


Assuntos
Memória Episódica , Autoimagem , Encéfalo/diagnóstico por imagem , Mapeamento Encefálico , Humanos , Imageamento por Ressonância Magnética , Reprodutibilidade dos Testes
13.
Plant Cell ; 33(7): 2320-2339, 2021 08 13.
Artigo em Inglês | MEDLINE | ID: mdl-34009394

RESUMO

Extreme temperature conditions seriously impair male reproductive development in plants; however, the molecular mechanisms underlying the response of anthers to extreme temperatures remain poorly described. The transcription factor phytochrome-interacting factor4 (PIF4) acts as a hub that integrates multiple signaling pathways to regulate thermosensory growth and architectural adaptation in plants. Here, we report that SlPIF4 in tomato (Solanum lycopersicum) plays a pivotal role in regulating cold tolerance in anthers. CRISPR (clustered regularly interspaced short palindromic repeats)-associated nuclease Cas9-generated SlPIF4 knockout mutants showed enhanced cold tolerance in pollen due to reduced temperature sensitivity of the tapetum, while overexpressing SlPIF4 conferred pollen abortion by delaying tapetal programmed cell death (PCD). SlPIF4 directly interacts with SlDYT1, a direct upstream regulator of SlTDF1, both of which (SlDYT1 and SlTDF1) play important roles in regulating tapetum development and tapetal PCD. Moderately low temperature (MLT) promotes the transcriptional activation of SlTDF1 by the SlPIF4-SlDYT1 complex, resulting in pollen abortion, while knocking out SlPIF4 blocked the MLT-induced activation of SlTDF1. Furthermore, SlPIF4 directly binds to the canonical E-box sequence in the SlDYT1 promoter. Collectively, these findings suggest that SlPIF4 negatively regulates cold tolerance in anthers by directly interacting with the tapetal regulatory module in a temperature-dependent manner. Our results shed light on the molecular mechanisms underlying the adaptation of anthers to low temperatures.

14.
Zhongguo Dang Dai Er Ke Za Zhi ; 23(5): 513-518, 2021 May.
Artigo em Chinês | MEDLINE | ID: mdl-34020743

RESUMO

OBJECTIVE: To study the change and significance of serum pentraxin-3 (PTX-3) and syndecan-4 in children with chronic heart failure (CHF). METHODS: A total of 40 children with CHF who were admitted to the Department of Pediatrics of the First Affiliated Hospital of Zhengzhou University were enrolled as the heart failure group, and 30 children who underwent physical examination in the outpatient service during the same period of time were enrolled as the control group. The serum levels of PTX-3, syndecan-4, and N-terminal pro-brain natriuretic peptide (NT-proBNP) were compared between the two groups. RESULTS: The children with CHF had significant reductions in the serum levels of PTX-3, syndecan-4, and NT-proBNP after treatment. The levels of these markers in children with CHF were significantly higher than the control group before and after treatment (P < 0.05). The CHF children with grade II/III/IV cardiac function had significantly higher serum levels of PTX-3 and syndecan-4 than the control group (P < 0.05). The levels of PTX-3 and syndecan-4 were related to the severity of cardiac function. Compared with the grade II cardiac function group, the grade IV cardiac function group had significant increases in the serum levels of PTX-3 and syndecan-4 (P < 0.05). The serum level of PTX-3 was positively correlated with that of syndecan-4 in children with CHF (rs=0.999, P < 0.05); the serum level of PTX-3 was positively correlated with NT-proBNP, left ventricular mass index (LVMI), and cardiac function grade (rs=0.726, 0.736, and 0.934 respectively, P < 0.05) and was negatively correlated with left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) (rs=-0.852 and -0.767 respectively, P < 0.05); the serum level of syndecan-4 was positively correlated with NT-proBNP, LVMI, and cardiac function grade (rs=0.733, 0.743, and 0.934 respectively, P < 0.05) and was negatively correlated with LVEF and LVFS (rs=-0.856 and -0.771 respectively, P < 0.05). CONCLUSIONS: Serum PTX-3 and syndecan-4 may be involved in the development and progression of ventricular remodeling in children with CHF and may be used as markers for the diagnosis, cardiac function grading, and treatment outcome evaluation of children with heart failure.


Assuntos
Insuficiência Cardíaca , Sindecana-4 , Biomarcadores , Proteína C-Reativa , Criança , Doença Crônica , Humanos , Peptídeo Natriurético Encefálico , Fragmentos de Peptídeos , Componente Amiloide P Sérico , Volume Sistólico , Função Ventricular Esquerda
15.
J Transl Int Med ; 9(1): 38-42, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33850800

RESUMO

Objective: This study aims to explore the necessity and safety of digestive endoscopy during the epidemic of coronavirus disease 2019. Methods: A retrospective cohort study method was used to collect patients' data from the endoscopy center of the Civil Aviation General Hospital of China from February 1 to May 31, 2020, as the observation group. The patients' data of endoscopic diagnosis and treatment during the same period in 2019 were used as a control group, to compare the differences in the number of diagnosis and treatment and the detection rate of gastrointestinal diseases in the two groups. At the same time, patients and related staff were followed up for the situation of new infection. Results: During the epidemic, our endoscopy center conducted a total of 1,808 cases of endoscopic operations and 5,903 cases in the control group. The amount of endoscopic work during the epidemic period was 30.63% in the same period last year. During the epidemic, 26 patients underwent endoscopic mucosal resection (EMR)/endoscopic submucosal dissection (ESD) treatment, 26 patients underwent ERCP, and 18 patients underwent gastrointestinal stent implantation. In the control group, 273 patients underwent EMR/ESD, 17 underwent ERCP, and 16 underwent gastrointestinal stenting. During COVID-19, compared with the same period last year, the detection rates of peptic ulcer, esophageal cancer, gastric cancer, colon cancer, and rectal cancer were significantly higher (χ 2 = 4.482, P = 0.034; χ 2 = 5.223, P = 0.006; χ 2 = 2.329, P = 0.041; χ 2 = 8.755, P = 0.003; and χ 2 = 5.136, P = 0.023). Through telephone follow-up, novel coronavirus nucleic acid detection and blood antibody detection, no patients or medical staff were infected with the novel coronavirus. Conclusion: During COVID-19, the number of digestive endoscopic operations decreased significantly compared with the same period last year, but the detection rate of various diseases of the digestive tract increased significantly. On the basis of strict prevention and control, orderly recovery of endoscopic work is essential.

16.
Neuropsychologia ; 155: 107824, 2021 05 14.
Artigo em Inglês | MEDLINE | ID: mdl-33713669

RESUMO

The physical attractiveness stereotype (PAS) is characterized by the belief that beauty is good and ugliness is bad. Although the belief is not encouraged, people still express "beauty is good" explicitly. However, expressing that ugliness is bad is considered impolite in public. In this study, the neural underpinnings of PAS were investigated, particularly the comparison of the neural processing of ugliness is bad and beauty is good. During functional magnetic resonance imaging scanning, participants were asked to create trait-conformity judgments based on the facial attractiveness of the images. Our results showed that brain areas, including the fusiform, thalamus, anterior insula (AI), precuneus, inferior temporal gyrus, dorsal lateral prefrontal cortex (dlPFC), and dorsal medial prefrontal cortex (dmPFC) were involved in the processing of PAS. The left AI, left dlPFC, and right dmPFC showed stronger activation for ugliness is bad than for the converse. Moreover, we found a stronger connectivity between the left dlPFC and AI in terms of ugliness is bad than in the converse. Our study suggests that participants were unwilling to express the stereotype of ugliness is bad, and more mental resources were needed to control its expression than the expression of beauty is good.


Assuntos
Beleza , Mapeamento Encefálico , Encéfalo/diagnóstico por imagem , Humanos , Julgamento , Imageamento por Ressonância Magnética
17.
Mol Plant Microbe Interact ; 34(7): 842-844, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33630650

RESUMO

Diaporthe-Phomopsis disease complex causes considerable yield losses in soybean production worldwide. As one of the major pathogens, Phomopsis longicolla T. W. Hobbs (syn. Diaporthe longicolla) is not only the primary agent of Phomopsis seed decay but is also one of the agents of Phomopsis pod and stem blight and Phomopsis stem canker. We performed both PacBio long-read sequencing and Illumina short-read sequencing and obtained a genome assembly for the strain P. longicolla YC2-1, which was isolated from soybean stem with Phomopsis stem blight disease. The 63.1 Mb genome assembly contains 87 scaffolds, with a minimum, maximum, and N50 scaffold length of 20 kb, 4.6 Mb, and 1.5 Mb respectively, and a total of 17,407 protein-coding genes. The high-quality data expand the genomic resource of P. longicolla species and will provide a solid foundation for a better understanding of their genetic diversity and pathogenic mechanisms.[Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.


Assuntos
Ascomicetos , Soja , Ascomicetos/genética , Phomopsis , Sementes
18.
Int J Mol Med ; 47(4)2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33576436

RESUMO

The present study was designed to investigate the structure and immunomodulatory activity of a polysaccharide. A novel acidic ß­glucan (WCCP­A­b; molecular weight, 7.3 kDa) was purified from the fruiting bodies of the edible mushroom Cantharellus cibarius, which possesses high nutritional values. WCCP­A­b was composed primarily of glucose (89.7%) and glucuronic acid (8.8%). Methylation and nuclear magnetic resonance analysis suggested that WCCP­A­b contained ß­D­1,6­glucan as its main chain, which was substituted at O­3 by ß­1,3­D­Glcp oligosaccharides or a single­unit of ß­Glcp residues. Minor ß­1,4­D­GlcpA residues may also be present in the side chains. The degree of branching was ~20.9%. Moreover, WCCP­A­b possessed a macrophage activating effect by promoting the secretion of nitric oxide, TNF­α and IL­6 in a dose­dependent manner. At a cellular mechanistic level, WCCP­A­b activated macrophages via the MAPK signaling pathway. The present results provided useful information for supporting further investigations on the structure­activity association of polysaccharides from C. cibarius, and indicated that the novel ß­glucan may be a potent natural immunomodulator, thus promoting the application of C. cibarius as a valuable source for functional food.


Assuntos
Basidiomycota/química , beta-Glucanas/química , beta-Glucanas/farmacologia , Animais , Sobrevivência Celular/efeitos dos fármacos , Feminino , Ativação de Macrófagos/efeitos dos fármacos , Camundongos , Camundongos Endogâmicos BALB C , Células RAW 264.7 , Transdução de Sinais/efeitos dos fármacos , Espectroscopia de Infravermelho com Transformada de Fourier
19.
Zhongguo Dang Dai Er Ke Za Zhi ; 23(1): 84-90, 2021 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-33476543

RESUMO

This article summarizes and analyzes the clinical features and gene mutation characteristics of children with noncompaction of the ventricular myocardium (NVM). For the 6 children with NVM (4 boys and 2 girls), the age of onset ranged from 3 months to 12 years. Of the 6 children, 5 had arrhythmia, 3 had cardiac insufficiency, 1 had poor mental state, and 1 had chest distress and sighing. NVM-related gene mutations were detected in 4 children, among whom 2 had MYH7 gene mutation, 1 had PRDM16 gene mutation, and 1 had mutations in the ACTN2 and TNNT2 genes. Four children had improvement in cardiac function. The two children with no significant improvement in cardiac function had a younger age of onset, a greater reduction in systolic function on echocardiography, and greater increases in myocardial enzyme and N-terminal pro-brain natriuretic peptide. It is concluded that for children with the initial symptoms of chest distress, sighing, arrhythmia, enlarged heart shadow, and increased myocardial enzyme, echocardiography and cardiac magnetic resonance are recommended for the diagnosis of NVM. NVM can have various genetic mutations.


Assuntos
Cardiomiopatias , Ventrículos do Coração , Criança , Pré-Escolar , Ecocardiografia , Feminino , Ventrículos do Coração/diagnóstico por imagem , Humanos , Lactente , Masculino , Mutação , Miocárdio
20.
Sleep Med ; 77: 339-345, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-32482485

RESUMO

BACKGROUND: The 2019 coronavirus disease (COVID-19) has spread worldwide, and its associated stressors have resulted in decreased sleep quality among front-line workers. However, in China, the general public displayed more psychological problems than the front-line workers during the pandemic. Therefore, we investigated the influence of perceived stress on the sleep quality of the non-diseased general public and developed a moderated mediation model to explain said relationship. METHODS: Questionnaire-based surveys were conducted online from February 18-25, 2020 with 1630 Chinese participants (aged 18-68 years). RESULTS: Around one-third (36.38%) of participants were poor sleepers during the COVID-19 pandemic. Moreover, higher perceived stress was significantly associated with higher anxiety levels, which, in turn, was associated with lower sleep quality. Self-esteem moderated the indirect effect of perceived stress on sleep quality through its moderation of the effect of perceived stress on anxiety. This indicated that the mediation effect of anxiety was stronger in those with low levels of self-esteem than in those with high levels of self-esteem. CONCLUSIONS: These findings suggest that both the sleep quality and perceived stress levels of the non-diseased general public required attention during the COVID-19 pandemic. Our findings also identify personality characteristics related to better sleep quality, demonstrating the important role of self-esteem in environmental adaptation.


Assuntos
Ansiedade/psicologia , Depressão/psicologia , Saúde Mental/estatística & dados numéricos , Transtornos do Sono-Vigília/psicologia , Estresse Psicológico/psicologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Ansiedade/epidemiologia , China/epidemiologia , Depressão/epidemiologia , Exercício Físico/psicologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Quarentena/psicologia , Fatores de Risco , Sono , Transtornos do Sono-Vigília/epidemiologia , Estresse Psicológico/epidemiologia
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