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1.
J Nutr Biochem ; : 108517, 2020 Oct 02.
Artigo em Inglês | MEDLINE | ID: mdl-33011286

RESUMO

Flavonols are bioactive substances in plant foods. In this study, two flavonols galangin and kaempferol were heated at 100°C for 30 min prior to assessing their effects on barrier function of rat intestinal epithelial (IEC-6) cells. Both heated and unheated flavonols (2.5-20 µmol/L dosages) were non-toxic to the cells up to 48 h post-treatment, and could promote cell viability values to 102.2-141.2% of control. By treatment with 5 µmol/L flavonols for 24 and 48 h, the treated cells time-dependently showed better improved physical and biological barrier functions than the control cells without any flavonol treatment, including higher transepithelial electrical resistance and anti-bacterial effect but reduced paracellular permeability and bacterial translocation. The results from real-time PCR and western-blot assays indicated that the cells treated with heated and unheated flavonols of 5 µmol/L dosage had up-regulated mRNA (1.13-1.81 folds) and protein (1.15-5.11 folds) expression for zonula occluden-1, occludin, and claudin-1 that are vital to the tight junctions (TJ) of the cells. Moreover, protein expression of RhoA and ROCK were down-regulated into 0.41-0.98 and 0.40-0.92 folds, respectively, demonstrating a Rho inactivation that led to enhanced cell barrier integrity via the RhoA/ROCK pathway. Overall, galangin was more active than kaempferol to perform three biofunctions like improving cell barrier function, up-regulating TJ protein expression, and down-regulating RhoA/ROCK expression. Moreover, the heated flavonols were less effective than the unheated counterparts to perform these biofunctions. It is concluded that this heat treatment of galangin and kaempferol could inhibit their benefits to improve barrier function of IEC-6 cells.

2.
J Food Biochem ; : e13488, 2020 Oct 04.
Artigo em Inglês | MEDLINE | ID: mdl-33015841

RESUMO

Jangkanghwan (JKH) can delay weight loss in mice, promote weight gain during recovery, and reduce colonic shortening and colon weight. In addition, the murine disease activity index was controlled after treatment using JKH. It can reduce the content of pro-inflammatory factors in serum and expression in tissues, such as interleukin (IL)-6, IL-1ß, tumor necrosis factor-α, interferon-γ, cyclooxygenase-2, and nuclear factor kappa-B; in contrast, the content and expression of IL-10 and the inhibitor of nuclear factor kappa-B kinase-α in the serum and tissues were increased. The mRNA expression of the colitis characteristic biomarker monocyte chemoattractant protein-1 and macrophage inflammatory protein-3α were reduced in colon tissues. Using next-generation sequencing technology, the Bacteroidetes phylum in the JKH group decreased, while the Firmicutes phylum increased, and the number of beneficial bacteria-Bifidobacteriaceae, Lactobacillaceae, and Akkermansiaceae-increased. PRACTICAL APPLICATIONS: JKH is a mixture of colonic healthy foods composed of Atractylodes macrocephala koidzumi, radish leaves, Viscum album var. coloratum, dried Zingiber officinale Roscoe, etc. According to UPLC-Q-TOF MS analysis, JKH consists mainly of 17 active substances, such as pheophorbide A, nabumetone alcohol, dehydrocostus lactone, plantamajoside, kaempferol 3, 7-dirhamnoside, quercetin 3-D-glucuronide, and viscumneoside III. We investigated the preventive effects of JKH on dextran sulfate sodium (DSS)-induced ulcerative colitis in a murine model and found that JKH can reduce the damage in mice caused by DSS treatment.

3.
Phys Chem Chem Phys ; 2020 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-33016284

RESUMO

Acoustic vibrations of Au and Ag elongated nano-objects with original morphologies, from Ag-Ag homodimers to Au@Ag-Ag heterodimers and Au@Ag eccentric core-shell spheroids, have been experimentally investigated by ultrafast time-resolved optical spectroscopy. Their frequencies, obtained by the analysis of time-dependent transient absorption changes, are compared with the results obtained from finite element modeling (FEM) numerical computations, which allow assignment of the detected oscillating signals to fundamental radial and extensional modes. FEM was further used to analyze the effects of morphology and composition on the vibrational dynamics. FEM computations indicate that (1) the central distance between particles forming the nanodimers has profound effects on the extensional mode frequencies and a negligible influence on the radial mode ones, in analogy with the case of monometallic nanorods, (2) coating Au with Ag also has a strong mass-loading-like effect on the dimer and core-shell stretching mode frequency, while (3) its influence on the radial breathing mode is smaller and analogous to the non-monotonic frequency dependence on the Au fraction previously observed in isotropic bimetallic spheres. These findings are significant for developing a predictive understanding of nanostructure mechanical properties and for designing new mechanical nanoresonators.

4.
Am J Emerg Med ; 2020 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-33041109

RESUMO

During the pandemic of 2019-nCoV, large public hospitals are facing great challenges. Multi-hospital development will be the main mode of hospital administrative management in China in the future. West China Hospital of Sichuan University implemented multi-hospital integrated management, in which the branch district established the administrative multi-department collaboration mode. As an important part of the operation of branch district, how to effectively organize transportation of staffs and patients and to prevent and control the pandemic of 2019-nCoV simultaneously between different hospitals have been the key and difficult points, which should be solved urgently in the management of the branch district.

5.
Nat Commun ; 11(1): 5036, 2020 10 07.
Artigo em Inglês | MEDLINE | ID: mdl-33028818

RESUMO

Alkyl carboxylic acids as well as primary amines are ubiquitous in all facets of biological science, pharmaceutical science, chemical science and materials science. By chemical conversion to redox-active esters (RAE) and Katritzky's N-alkylpyridinium salts, respectively, alkyl carboxylic acids and primary amines serve as ideal starting materials to forge new connections. In this work, a Mn-mediated reductive decarboxylative/deaminative functionalization of activated aliphatic acids and primary amines is disclosed. A series of C-X (X = S, Se, Te, H, P) and C-C bonds are efficiently constructed under simple and mild reaction conditions. The protocol is applicable to the late-stage modification of some structurally complex natural products or drugs. Preliminary mechanistic studies suggest the involvement of radicals in the reaction pathway.

6.
World J Surg Oncol ; 18(1): 262, 2020 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-33032609

RESUMO

BACKGROUND: Pancreaticoduodenectomy is the only definitively curative therapy for the long-term survival of distal cholangiocarcinoma patients. Lymph node metastasis is widely accepted as an important prognostic factor for distal cholangiocarcinoma. The latest American Joint Committee on Cancer (AJCC) TNM classification system for distal cholangiocarcinoma has divided the lymph node metastasis patients into N1 and N2 by lymph node metastasis number. However, some studies suggested that the lymph node metastasis ratio may be better than the lymph node metastasis number. Therefore, we develop a program to analyze the correlation between lymph node parameters (lymph node dissection number, lymph node metastasis number, and lymph node metastasis rate) and long-term prognosis. METHODS: We retrospectively reviewed 123 distal cholangiocarcinoma patients after pancreatoduodenectomy from January 2011 to December 2019. The patients were grouped according to lymph node metastases and tumor-free and overall survival rates which were investigated with the Kaplan-Meier analysis. The logistic regression models were used for multivariate analysis to determine the risk factors for lymph node metastases. And the X-tile program was used to calculate the cutoff values for the lymph node parameters that discriminated survival. RESULTS: The 1-year, 3-year, and 5-year overall survival rates of patients with distal cholangiocarcinoma after pancreatoduodenectomy were 75.2%, 37.1%, and 31.5%, respectively. And the 1-year, 3-year, and 5-year overall survival rates of patients without and with lymph node metastasis were 83.0%, 50.7%, and 42.5% and 63.5%, 19.0%, and 19.0% (p = 0.000), respectively. Logistic regression showed CA19-9 and portal vein system invasion as independent risk factors for lymph node metastases. The receiver operating characteristic curve showed the optimal cutoff value of CA19-9 to predict the lymph node metastases was 75.5 U/mL. Determined by the X-tile software, the optimal cutoff values of the lymph node dissection number were 24 (p = 0.021), the lymph node metastasis number were 1 and 7 (p = 0.504), and the lymph node metastasis rate were 0.13 (p = 0.002). CONCLUSION: Lymph node metastasis is an important factor affecting the long-term survival of distal cholangiocarcinoma patients.CA19-9 and portal vein system invasion are independent risk factors for lymph node metastasis. Besides, the lymph node dissection number and lymph node metastasis rate can predict the long-term survival better than lymph node metastasis number.

7.
Cardiovasc Res ; 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33002105

RESUMO

AIMS: Stem cell therapy has shown promise for treating myocardial infarction (MI) via re-muscularization and paracrine signaling in both small and large animals. Non-human primates (NHPs), such as rhesus macaques (Macaca mulatta), are primarily utilized in preclinical trials due to their similarity to humans, both genetically and physiologically. Currently, induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) are delivered into the infarcted myocardium by either direct cell injection or an engineered tissue patch. Although both approaches have advantages in terms of sample preparation, cell-host interaction, and engraftment, how the iPSC-CMs respond to ischemic conditions in the infarcted heart under these two different delivery approaches remain unclear. Here we aim to gain a better understanding of the effects of hypoxia on iPSC-CMs at the transcriptome level. METHODS AND RESULTS: NHP iPSC-CMs in both monolayer culture (2 D) and engineered heart tissue (EHT) (3 D) format were exposed to hypoxic conditions to serve as surrogates of direct cell injection and tissue implantation in vivo, respectively. Outcomes were compared at the transcriptome level. We found the 3 D EHT model was more sensitive to ischemic conditions and similar to the native in vivo myocardium in terms of cell-extracellular matrix/cell-cell interactions, energy metabolism, and paracrine signaling. CONCLUSIONS: By exposing NHP iPSC-CMs to different culture conditions, transcriptome profiling improves our understanding of the mechanism of ischemic injury. TRANSLATIONAL PERSPECTIVE: Stem cell therapy has shown promise for treating ischemic heart tissue. However, how stem cells respond following different delivery method is unclear. Here hypoxic conditioning was applied to non-human primate iPSC-CMs in 2 D monolayer culture and 3 D engineered heart tissue to model cell injection versus patch implantation, respectively, in an ischemic milieu. The differential transcriptome of hypoxic effects on iPSC-CMs show upregulation of ECM-cell/cell-cell interactions (COL9A1, ITGB6, CTSV, and EPHA1), energy metabolism/hypoxia (ALDOC, ENO2, PFKFB4, CA3, and CA9), and paracrine signaling (WNT, PDGF, FGFR, EGFR, PI3K, and VEGF) in the 3 D format, which suggest engineered heart tissue as more suitable model for evaluating cardiac regenerative therapy.

8.
Diabetes Metab Res Rev ; : e3414, 2020 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-33010796

RESUMO

Diabetic retinopathy (DR) is one of the leading causes of blindness worldwide, and the limited availability of qualified ophthalmologists restricts its early diagnosis. For the past few years, artificial intelligence technology has developed rapidly and has been applied in DR screening. The upcoming technology provides support on DR screening and improves the identification of DR lesions with a high sensitivity and specificity. This review aims to summarize the progress on automatic detection and classification models for the diagnosis of DR. This article is protected by copyright. All rights reserved.

9.
Artigo em Inglês | MEDLINE | ID: mdl-33017810

RESUMO

An appropriate treatment of electronic correlation effects plays an important role in accurate descriptions of physical and chemical properties of real materials. The recently proposed Correlation Matrix Renormalization theory with Sum Rule correction (CMR) for studying correlated electron materails has shown good performance in molecular systems and a periodic Hydrogen chain in comparison with various quantum chemistry and quantum Monte Carlo calculations. This work gives a detailed formulation and computational code implementation of CMR in multi-band periodic lattice systems. This lattice CMR ab initio theory is highly efficient, has no material specific adjustable parameters, and has no double counting issues faced by the hybrid approaches like LDA+U, DFT+DMFT and DFT+GA type theories. Benchmark studies on materials with s and p orbitals in this study show that CMR in its current implementation consistently performs well for these systems as the electron correlation increases from the bonding region to the bond breaking region.

10.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1679-1682, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33018319

RESUMO

Epilepsy is one of the largest neurological diseases in the world, and juvenile myoclonic epilepsy (JME) usually occurs in adolescents, giving patients tremendous burdens during growth, which really needs the early diagnosis. Advanced diffusion magnetic resonance imaging (MRI) could detect the subtle changes of the white matter, which could be a non-invasive early diagnosis biomarker for JME. Transfer learning can solve the problem of insufficient clinical samples, which could avoid overfitting and achieve a better detection effect. However, there is almost no research to detect JME combined with diffusion MRI and transfer learning. In this study, two advanced diffusion MRI methods, high angle resolved diffusion imaging (HARDI) and neurite orientation dispersion and density imaging (NODDI), were used to generate the connectivity matrix which can describe tiny changes in white matter. And three advanced convolutional neural networks (CNN) based transfer learning were applied to detect JME. A total of 30 participants (15 JME patients and 15 normal controls) were analyzed. Among the three CNN models, Inception_resnet_v2 based transfer learning is better at detecting JME than Inception_v3 and Inception_v4, indicating that the "short cut" connection can improve the ability to detect JME. Inception_resnet_v2 achieved to detect JME with the accuracy of 75.2% and the AUC of 0.839. The results support that diffusion MRI and CNN based transfer learning have the potential to improve the automated detection of JME.

11.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 3003-3006, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33018637

RESUMO

Exploring the brain response to stimuli of healthy people in passive state is helpful to understand the brain response mechanism of unresponsive people. Event-related potential (ERP) can reflect the time synchronization of potentials, which is a feasible objective electrophysiological index reflecting the functional status of the brain. In this paper, we used the subjects' own name (SON) as target stimuli and compared with the nontarget stimuli (others' name) of Three Chinese Characters (3CC) and Two Chinese Characters (2CC) with the same stimuli duration (600ms) and inter stimuli interval (500ms-800ms). Thirteen healthy subjects attended in this study with four conditions ( [active, passive]×[3CC, 2CC] ). We compared the ERP waveforms, the behavior performance, and the classification of four different conditions. ERP results show that the P300 amplitude of conditions with 3CC nontargets is higher than that of conditions with 2CC nontargets. Behavioral results show that the grand accuracy is 97% when the nontargets are 3CC, while the grand accuracy is only 94% when the nontargets are 2CC. The reaction time is also different from the two nontargets (605ms with 3CC vs 635ms with 2CC). Classification results illustrate that in active condition, the accuracy rate is 82.1% when the nontarget is 3CC, and that is 80.9% in passive condition, which are 4.2% and 6.4% higher than the accuracy rate under 2CC cases in both active and passive conditions. This study can provide a scheme for grading diagnosis of consciousness detection, and further applying to clinical evaluation.Clinical Relevance- This study can provide a better paradigm basis for clinical evaluation of unresponsive patients (such as disorder of consciousness, DOC) and may become an effective auxiliary means for clinical rating scales.

12.
Orthop Surg ; 2020 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-33000548

RESUMO

Anatomic tunnel formation and remnant preservation are the recent trends in posterior cruciate ligament (PCL) reconstruction. However, it is difficult to observe the anatomical PCL footprint and perform the operation in the process of remnant-preserving PCL reconstruction. This study describes a single-bundle, transtibial PCL reconstruction technique with anatomic graft passage over the remnant PCL fibers. A femoral tunnel of PCL is created at 2 mm medial to the roof of the intercondylar notch and 3 mm proximal to the margin of the articular cartilage. The tibial insertion of PCL is observed using a figure-of-four position through a posterior trans-septal portal. A tibial bone tunnel is made below the distal center portion of the tibial insertion of residual PCL fibers. The graft is passed over the PCL through the tibial bone tunnel, the space between the anterior cruciate ligament (ACL) and the residual PCL fibers, to the femoral socket and is fixed by the EndoButton and screw. This technique is able to ensure a reasonable intra-articular length and optimal isometry. It has been applied in patients with PCL rupture and posterior instability of the knee joint, and no intraoperative or postoperative complications occurred. Our technology provides a valuable new treatment option for PCL rupture. Future comparative studies are needed to further clarify its beneficial effect.

13.
Chem Commun (Camb) ; 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33000826

RESUMO

Correction for 'Electrochemically shape-controlled synthesis of great stellated dodecahedral Au nanocrystals with high-index facets for nitrogen reduction to ammonia' by Yu-Chen Jiang et al., Chem. Commun., 2020, DOI: 10.1039/d0cc04326e.

14.
Mikrochim Acta ; 187(10): 587, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33001259

RESUMO

Pt deposited on CdS nanorods (Pt/CdS) have been prepared via the UV light photoreduction method. The Pt/CdS nanocomposites possess highly significant peroxidase-like activity with the assistance of the colorless substrate 3,3,5,5-tetramethylbenzidine (TMB). In the presence of peroxidase mimic Pt/CdS, TMB is quickly oxidized into a typical blue product (oxTMB, which has an obvious absorption at 652 nm) by H2O2 only in 3 min, which is easily detected visually. The catalytic activity of Pt/CdS originates from the accelerated electron transfer between the reactants. Combining the peroxidase-like activity of Pt/CdS with the blue change of TMB, a fast colorimetric sensing platform for detection of H2O2 has been constructed with a linear range 0.10-1.00 mM and a detection limit of 45.5 µM. The platform developed is further used to detect hydroquinone (HQ) in the range1.0-10 µM with a lower detection limit of 0.165 µM. The colorimetric platform has a potential to detect HQ residue in real water samples with recoveries ranging from 83.56 to 91.76%. Graphical abstract.

15.
Genes (Basel) ; 11(10)2020 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-33003522

RESUMO

Mammals have variable numbers (1300-2000) of transcription factors (TFs), but the reasons for this large variation are unclear. To investigate general TF patterns, we de novo identified 156,906 TFs from 96 mammalian species. We identified more than 500 human isolated TFs that are rarely reported in human TF-to-TF networks. Mutations in the genes of these TFs were less lethal than those of connected TFs. Consequently, these isolated TFs are more tolerant of changes and have become unique during speciation. They may also serve as a source of variation for TF evolution. Reconciliation of TF-family phylogenetic trees with a mammalian species tree revealed an average of 37.8% TF gains and 15.0% TF losses over 177 million years, which implies that isolated TFs are pervasive in mammals. Compared with non-TF interacting genes, TF-interacting genes have unique TF profiles and have higher expression levels in mice than in humans. Different expression levels of the same TF-interacting gene contribute to species-specific phenotypes. Formation and loss of isolated TFs enabling unique TF profiles may provide variable switches that adjust divergent expression profiles of target genes to generate species-specific phenotypes, thereby making species unique.

16.
J Food Biochem ; : e13491, 2020 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33006202

RESUMO

Lactic acid bacteria (LAB) are an important group of microorganisms in the food industry. LAB with health benefits are considered natural elements promoting consumer health. The study investigated the anti-obesity effects of Lactobacillus plantarum CQPC01 (LP-CQPC01) on high-fat diet-induced mice. Liver morphology, liver function indexes, lipid indexes, and inflammatory factors in the serum and liver were determined. Expressions of lipid metabolism-related gene were also detected by qPCR. LP-CQPC01 slowed the HFD-induced increase in body weight, decreased the organ indexes, alleviated hepatic lipid accumulation, and inhibited the increased adipose cell volume. LP-CQPC01 decreased lipid levels of serum and liver, and the contents of pro-inflammatory factors, and increased the IL-4 and IL-10 contents. LP-CQPC01 downregulated the expressions of the C/EBP-α and PPARγ mRNA and upregulated CYP7A1, CPT1, LPL, CAT, SOD1, and SOD2 mRNA. Our results indicated that LP-CQPC01 is a potential probiotic for preventing or alleviating high-energy intake-related lipid conditions. PRACTICAL APPLICATIONS: Obesity is a factor of a variety of cardiovascular diseases. Therefore, it is necessary to suppress the occurrence of fat accumulation in time. This study investigated the effect of LP-CQPC01 on lipid regulation in mice fed a high-fat diet (HFD) and clarified the mechanism of strain to alleviate obesity by enhancing the decomposition of cholesterol and detoxification of fat. LP-CQPC01 reduced fat accumulation without oxidative damage, and was confirmed by the attenuated pathological changes of liver. This research can serve as a significant reference for future research, prevention, and treatment of high-energy intake-related lipid conditions, and the development of functional foods with anti-obesity activity.

17.
Water Res ; 188: 116473, 2020 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-33038718

RESUMO

Sand biofilters (SBFs) are commonly used to remove manganese (Mn(II)) from drinking water. Mn(II) load variation frequently occurs in SBFs due to fluctuating influent Mn(II) concentrations or flow rates. Therefore, it is important to understand the responses of microbial biofilms in SBFs to environmental disturbances and how they affect Mn(II) oxidation efficiency. Here, the responses of microbial ecological networks and Mn(II) removal in SBFs to increasing Mn(II) load were investigated. The Mn(II) removal efficiency in two SBFs remained at 99.8% despite an increase in influent Mn(II) from 2 mg/L to 4 mg/L, but significantly deteriorated (50.1-58.5%) upon increasing the filtration rate. A canonical correlation analysis of the microbial communities indicated that the local Mn(II) concentration and biofilter depth impacted community compositions of biofilms. The dominant species within the biofilms exhibited clear stratification, with simple associations in the upper layer of the SBFs and more complex interspecies interactions in the bottom layers. Putative manganese-oxidizing bacteria Hyphomicrobium and Pedomicrobium dominated the microbiomes in different layers of SBFs, and changed relatively little in abundance when Mn(II) and filtration rate increased. The community networks showed that biofilm microbiomes in SBFs were resilient to the disturbance of Mn(II) load, primarily via regulating microbial interactions. High manganese loads negatively affected the functional modules for Mn(II) removal. Furthermore, the relatively rare species Candidatus Entotheonella palauensis was identified as a module hub, implying taxa with low abundances can have important roles in ecosystem function. These results shed new light on the ecological rules guiding responses of microbiomes in sand biofilters to environmental stress.

18.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ; 34(9): 836-839;843, 2020 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-33040510

RESUMO

Objective:A prospective randomized controlled study of patients with thyroid papillary carcinoma requiring lateral neck dissection was conducted to investigate the thoroughness, safety and cosmetic features of endoscope-assisted lateral neck dissection. Method:Patients who underwent total thyroidectomy, bilateral central lymph node dissection and unilateral lateral neck dissection for papillary thyroid cancer were randomly divided into two groups: endoscopic assisted group and open group, 18 cases in each group. The clinical characteristics, operation conditions, postoperative complications and aesthetic satisfaction of the two groups were compared. Result:There were no statistically significant differences between the endoscopic group and the open group in age, gender, tumor size, dissection side, operation time, postoperative hospital stay, number of lymph nodes to be dissected, number of metastatic lymph nodes, postoperative hoarseness, and hypoparathyroidism(P>0.05); No hematoma or lymphatic leakage occurred in the two groups after surgery, and no tumor recurrence or residual was found in the ultrasound review at 6 months after surgery. Serum Tg level in the endoscopic group was higher than that in the open group at 6 months after surgery, but the difference between the two groups was not statistically significant(P>0.05); The neck pain score at day 3 after operation, the neck numbness and discomfort score at month 1 after operation, and the aesthetic satisfaction score at 3 months after operation in the endoscope assisted group were better than that in the open group(P<0.05). Conclusion:Endoscope-assisted lateral neck dissection is safe, feasible and with excellent cosmetic effect for the treatment of lymph node metastasis in the lateral cervical region of papillary thyroid carcinoma.


Assuntos
Carcinoma Papilar , Câncer Papilífero da Tireoide , Neoplasias da Glândula Tireoide , Carcinoma Papilar/cirurgia , Humanos , Recém-Nascido , Linfonodos , Metástase Linfática , Esvaziamento Cervical , Estudos Prospectivos , Câncer Papilífero da Tireoide/cirurgia , Neoplasias da Glândula Tireoide/cirurgia
19.
J Hazard Mater ; 404(Pt A): 124130, 2020 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-33045462

RESUMO

Phthalic acid esters (PAEs) such as dimethyl phthalate (DMP) have been widely used as a plasticizer in society, which pose severe harm to human health. In this study, the potential of DMP elimination and nitrogen removal from low-carbon wastewaters by intermittently-aerated subsurface flow constructed wetlands (SSFCWs) was evaluated, and the effect of the influent DMP concentrations on nitrogen removal was also investigated. The results showed a better removal of DMP (88.5-97.8%) was obtained in CWs under different influent DMP concentrations, and the high removal of COD (86.7-95.0%) and NH4+-N (95.5-98.7%) was also achieved simultaneously. The maximum TN removal (48.7%) was observed at an influent DMP concentration of 10 mg L-1. Furthermore, the TN removal and DMP reduction had a good fitting relationship (R2 = 0.71) in CWs under different influent DMP concentrations. The analysis of DMP decomposition processes demonstrated that DMP was degraded into some smaller molecular fractions, and DMP degradation intermediates mainly including monomethyl phthalate (MMP) and phthalate (PA), which might provide a potential carbon source for the denitrification processes in CWs. These findings could contribute to a better understanding of DMP removal mechanism and provide useful guidance for the practical application of CWs for treating wastewater containing phthalates.

20.
Compr Psychiatry ; 103: 152209, 2020 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-33045669

RESUMO

BACKGROUND: In neonatal rats, MK-801 treatments can produce schizophrenia-like symptoms. Crocin is a water soluble carotenoid in Saffron that exerts potent neuroprotective effects. This work aimed to demonstrate the function of crocin in the alleviation of motor and cognitive impairments elicited by MK-801 in a neonatal rodent schizophrenia model, and to illustrate the underlying molecular mechanisms. METHODS: Rats were treated with vehicle, MK-801 (1 mg/kg), MK-801 + 25 mg/kg crocin, or MK-801 + 50 mg/kg crocin. Motor learning and coordination, locomotion and exploratory activities, as well as spatial memory were assessed using the rotarod test, pen field test, and the Morris water maze test, respectively. Relative mRNA and protein levels of genes of interest were analyzed using qRT-PCR and Western blot assays, respectively. RESULTS: In the hippocampus of rats with MK-801-elicited schizophrenia, administration of crocin elevated the expression of silent information regulator-1 (SIRT1) and brain derived neurotrophic factor (BDNF), and relieved the oxidative stress. The learning deficits and motor perturbations caused by MK-801 treatments were also alleviated by the crocin administration. CONCLUSION: Collectively, crocin has exerted neuroprotective effects in the rat model of MK-801-elicited schizophrenia, via regulations of SIRT1 and downstream BDNF expression in the hippocampus.

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