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1.
J Colloid Interface Sci ; 630(Pt B): 751-761, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36347101

RESUMO

Spinel iron cobaltite (FeCo2O4) with high theoretical capacity is a promising positive electrode material for building high-performance supercapacitors. However, its inherent poor conductivity and deficient electrochemical active sites hinder the improvement of its electrochemical kinetics behavior. Herein, phosphate ions modified FeCo2O4 is obtained in the presence of oxygen vacancies (P-FeCo2O4-x) by a simple metal organic framework gel-derived strategy. Phosphate ions added on the surface of P-FeCo2O4-x greatly enhances its surface activity, thus prompting the faster charge storage kinetics of the electrode material. Due to its ample electrochemical active sites and rapid ion diffusion and electron mobility, the optimized P-FeCo2O4-x electrode delivers a superior specific capacity of 1568.8 F g-1 (784.4 C g-1) at a current density of 1 A/g and has an excellent cycling stability with 93.3 % initial capacity retention ratio after 5000 cycles. More impressively, the assembled asymmetric supercapacitor consisting of P-FeCo2O4-x and activated carbon which act as positive and negative electrode materials, respectively displays a favorable energy density of 60.2 Wh kg-1 at a power density of 800 W kg-1 and has a long cycling lifespan. These results demonstrate the potential importance of modifying the surface of spinel cobaltite with phosphate ions and incorporating oxygen defects in it as a facile strategy for enhancing the electrochemical kinetics of electrode materials.

2.
Spectrochim Acta A Mol Biomol Spectrosc ; 284: 121832, 2023 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-36088741

RESUMO

Total antioxidant capacity (TAC) is an important indicator for evaluating oxidative stress of the human body. Since TAC is related to the concentration of reducing substances, it can be detected by using peroxidase-like or oxidase-like activity of nanozyme materials. In this work, the cobalt and nitrogen co-doped carbon dots (Co/N-CDs) are fabricated for building stability and high peroxidase-like nanozyme through the Box-Behnken design of response surface methodology. The morphology and luminescence properties of obtained Co/N-CDs were characterized by TEM and fluorophotometer, respectively. Interestingly, the surface charge of Co/N-CDs are innovatively investigated by a simple and widespread gel electrophoresis, which holds the potential to be an alternative to Zeta potential analysis. In addition, a flow injection spectrophotometric assay to detect ascorbic acid is develop with a high sensitivity and automation based on a Co/N-CDs/guaiacol/H2O2 catalytic reaction system. The proposed method is also responsive to other reducing substances such as cysteine and glutathione. Therefore, the presented sensor can realize the determination of TAC, and then, some actual human serum samples are detected accurately and quickly (the recovery rates are 93.46-105.61 %).


Assuntos
Carbono , Pontos Quânticos , Antioxidantes/análise , Ácido Ascórbico , Cobalto , Cisteína/análise , Glutationa , Guaiacol , Humanos , Peróxido de Hidrogênio/análise , Nitrogênio , Peroxidase , Peroxidases
3.
Chemosphere ; 311(Pt 1): 137039, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36342026

RESUMO

Limited information is available on the links between heavy metals' exposure and coronary heart disease (CHD). We aim to establish an efficient and explainable machine learning (ML) model that associates heavy metals' exposure with CHD identification. Our datasets for investigating the associations between heavy metals and CHD were sourced from the US National Health and Nutrition Examination Survey (US NHANES, 2003-2018). Five ML models were established to identify CHD by heavy metals' exposure. Further, 11 discrimination characteristics were used to test the strength of the models. The optimally performing model was selected for identification. Finally, the SHapley Additive exPlanations (SHAP) tool was used for interpreting the features to visualize the selected model's decision-making capacity. In total, 12,554 participants were eligible for this study. The best performing random forest classifier (RF) based on 13 heavy metals to identify CHD was chosen (AUC: 0.827; 95%CI: 0.777-0.877; accuracy: 95.9%). SHAP values indicated that cesium (1.62), thallium (1.17), antimony (1.63), dimethylarsonic acid (0.91), barium (0.76), arsenous acid (0.79), total arsenic (0.01) in urine, and lead (3.58) and cadmium (4.66) in blood positively contributed to the model, while cobalt (-0.15), cadmium (-2.93), and uranium (-0.13) in urine negatively contributed to the model. The RF model was efficient, accurate, and robust in identifying an association between heavy metals' exposure and CHD among US NHANES 2003-2018 participants. Cesium, thallium, antimony, dimethylarsonic acid, barium, arsenous acid, and total arsenic in urine, and lead and cadmium in blood show positive relationships with CHD, while cobalt, cadmium, and uranium in urine show negative relationships with CHD.


Assuntos
Arsênio , Doença das Coronárias , Poluentes Ambientais , Metais Pesados , Urânio , Adulto , Humanos , Inquéritos Nutricionais , Cádmio/urina , Antimônio , Exposição Ambiental/análise , Bário , Tálio , Cobalto/urina , Césio , Doença das Coronárias/epidemiologia , Aprendizado de Máquina
4.
Childs Nerv Syst ; 2022 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-36316483

RESUMO

PURPOSE: Lateral ventricle meningiomas (LVM) in children are very rare. The current research is mostly limited to adults, and there are very few related studies on children. The purpose of this study was to analyze the clinicopathological and imaging features of lateral ventricle meningiomas in children. METHODS: A retrospective analysis of five children with pathologically confirmed lateral ventricle meningioma was performed, and we collected clinical data, including clinicopathological data, treatment prognosis data, and imaging features (including tumor location, signal intensity, enhancement degree, intratumoral cyst, calcification, peritumoral edema, and associated hydrocephalus). RESULTS: Among the 5 patients with LVM, 4 were male and 1 was female with an average age of 7.6 years (range 2 to 12 years). All CT scans showed slight hyperintensity or isodensity, and only 1 patient had calcification. Two patients demonstrated cyst changes. Four patients had varying degrees of peritumoral edema. The average tumor volume was 164.1 cm3 (1.4-314.9 cm3). All 5 patients with LVM were iso- or hypointense on T1WI. The T2WI signals had no obvious features. Four patients had a high signal on DWI (80%). The contrast-enhanced signals were mostly homogeneously strong (80%). MRI showed hydrocephalus in 3 patients. All patients underwent gross total resection, and they were followed up regularly after the operation. The average follow-up time was 47.4 months. No recurrence was found in any of the children. All patients were pathologically confirmed to have meningiomas, and WHO grades were all grade I. CONCLUSION: Lateral ventricle meningiomas in children are very rare, and the imaging manifestations of the tumor have certain characteristics, but the clinical diagnosis is still difficult, and the diagnosis still requires pathological analysis.

5.
Chem Sci ; 13(37): 11110-11118, 2022 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-36320462

RESUMO

Nanoclusters (NCs) are considered as initial states of condensed matter, and unveiling their formation mechanism is of great importance for directional synthesis of nanomaterials. Here, we initiate the reaction of Ag(i) ions under weak reducing conditions. The prolonged reaction period provides a unique opportunity for revealing the five stages of the growth mechanism of 20-electron superatomic Ag70 NCs by a time-dependent mass technique, that is, aggregate (I) → reduction (II) → decomposition and recombination (III) → fusion (IV) → surface recombination and motif enrichment (V), which is different from the formation process applicable to the gold clusters. More importantly, the key intermediates, Ag14 without free electrons (0e) in the first (stage I) and Ag24 (4e) in the second (stage II), were crystallized and structurally resolved, and the later transformation rate towards Ag70 was further controlled by modulating solvents for easy identification of more intermediates. In a word, we establish a reasonable path of gradual expansion in size and electrons from Ag(i) ions to medium-sized 20e Ag70. This work provides new insights into the formation and evolution of silver NCs, and unveils the corresponding optical properties along with the process.

7.
Mitochondrial DNA B Resour ; 7(10): 1864-1866, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36325281

RESUMO

Zygophyllum kansuense Y. X. Liou is a localized species and endemic to China. In this study, the complete chloroplast genome of Z. kansuense was sequenced and described. The length of complete chloroplast genome was 105,383 base pairs (bp) for Z. kansuense, the genome with 33.8% GC content, containing a large single-copy (LSC) of 79,594 bp, a small single-copy (SSC) of 17,061 bp, and a pair of inverted repeats (IRs) of 4,364 bp. The genome contains 112 genes, including 75 protein-coding genes, 33 tRNA genes, and four rRNA genes. The phylogenetic analysis indicated that Z. kansuense and others of Zygophyllum clustered into one clade with a high support value.

8.
Small Methods ; : e2201142, 2022 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-36333209

RESUMO

Although birnessite-type manganese dioxide (δ-MnO2 ) with a large interlayer spacing (≈7 Å) is a promising cathode candidate for aqueous Zn/MnO2 batteries, the poor structural stability associated with Zn2+ intercalation/deintercalation limits its further practical application. Herein, δ-MnO2 ultrathin nanosheets are coupled with reduced graphene oxide (rGO) via van der Waals (vdW) self-assembly in a vacuum freeze-drying process. It is interesting to find that the presence of vdW interaction between δ-MnO2 and rGO can effectively suppress the layered-to-spinel phase transition in δ-MnO2 during cycling. As a result, the coupled δ-MnO2 /rGO hybrid cathode with a sandwich-like heterostructure exhibits remarkable cycle performance with 80.1% capacity retained after 3000 cycles at 2.0 A g-1 . The first principle calculations demonstrate that the strong interfacial interaction between δ-MnO2 and rGO results in improved electron transfer and strengthened layered structure for δ-MnO2 . This work establishes a viable strategy to mitigate the adverse layered-to-spinel phase transition in layered manganese oxide in aqueous energy storage systems.

9.
Artigo em Inglês | MEDLINE | ID: mdl-36369395

RESUMO

PURPOSE: To construct and validate a combined nomogram model based on magnetic resonance imaging (MRI) radiomics and Albumin-Bilirubin (ALBI) score to predict therapeutic response in unresectable hepatocellular carcinoma (HCC) patients treated with hepatic arterial infusion chemotherapy (HAIC). METHODS: The retrospective study was conducted on 112 unresectable HCC patients who underwent pretherapeutic MRI examinations. Patients were randomly divided into training (n = 79) and validation cohorts (n = 33). A total of 396 radiomics features were extracted from the volume of interest of the primary lesion by the Artificial Kit software. The least absolute shrinkage and selection operator (LASSO) regression was applied to identify optimal radiomic features. After feature selection, three models, including the clinical, radiomics, and combined models, were developed to predict the non-response of unresectable HCC to HAIC treatment. The performance of these models was evaluated by the receiver operating characteristic curve. According to the most efficient model, a nomogram was established, and the performance of which was also assessed by calibration curve and decision curve analysis. Kaplan-Meier curve and log-rank test were performed to evaluate the Progression-free survival (PFS). RESULTS: Using the LASSO regression, we ultimately selected three radiomics features from T2-weighted images to construct the radiomics score (Radscore). Only the ALBI score was an independent factor associated with non-response in the clinical model (P = 0.033). The combined model, which included the ALBI score and Radscore, achieved better performance in the prediction of non-response, with an AUC of 0.79 (95% CI 0.68-0.90) and 0.75 (95% CI 0.58-0.92) in the training and validation cohorts, respectively. The nomogram based on the combined model also had good discrimination and calibration (P = 0.519 for the training cohort and P = 0.389 for the validation cohort). The Kaplan-Meier analysis also demonstrate that the high-score patients had significantly shorter PFS than the low-score patients (P = 0.031) in the combined model, with median PFS 6.0 vs 9.0 months. CONCLUSION: The nomogram based on the combined model consisting of MRI radiomics and ALBI score could be used as a biomarker to predict the therapeutic response of unresectable HCC after HAIC.

10.
Mol Divers ; 2022 Nov 11.
Artigo em Inglês | MEDLINE | ID: mdl-36369613

RESUMO

Kinase plays a significant role in various disease signaling pathways. Due to the highly conserved sequence of kinase family members, understanding the selectivity profile of kinase inhibitors remains a priority for drug discovery. Previous methods for kinase selectivity identification use biochemical assays, which are very useful but limited by the protein available. The lack of kinase selectivity can exert benefits but also can cause adverse effects. With the explosion of the dataset for kinase activities, current computational methods can achieve accuracy for large-scale selectivity predictions. Here, we present a multimodal multi-task deep neural network model for kinase selectivity prediction by calculating the fingerprint and physiochemical descriptors. With the multimodal inputs of structure and physiochemical properties information, the multi-task framework could accurately predict the kinome map for selectivity analysis. The proposed model displays better performance for kinase-target prediction based on system evaluations.

11.
Cell Mol Immunol ; 2022 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-36348079

RESUMO

Tissue-resident macrophages are derived from different precursor cells and display different phenotypes. Reconstitution of the tissue-resident macrophages of inflamed or damaged tissues in adults can be achieved by bone marrow-derived monocytes/macrophages. Using lysozyme (Lysm)-GFP-reporter mice, we found that alveolar macrophages (AMs), Kupffer cells, red pulp macrophages (RpMacs), and kidney-resident macrophages were Lysm-GFP-, whereas all monocytes in the fetal liver, adult bone marrow, and blood were Lysm-GFP+. Donor-derived Lysm-GFP+ resident macrophages gradually became Lysm-GFP- in recipients and developed gene expression profiles characteristic of tissue-resident macrophages. Thus, Lysm may be used to distinguish newly formed and long-term surviving tissue-resident macrophages that were derived from bone marrow precursor cells in adult mice under pathological conditions. Furthermore, we found that Irf4 might be essential for resident macrophage differentiation in all tissues, while cytokine and receptor pathways, mTOR signaling pathways, and fatty acid metabolic processes predominantly regulated the differentiation of RpMacs, Kupffer cells, and kidney macrophages, respectively. Deficiencies in ST2, mechanistic target of rapamycin (mTOR) and fatty acid-binding protein 5 (FABP5) differentially impaired the differentiation of tissue-resident macrophages from bone marrow-derived monocytes/macrophages in the lungs, liver, and kidneys. These results indicate that a combination of shared and unique signaling pathways coordinately shape tissue-resident macrophage differentiation in various tissues.

12.
Curr Issues Mol Biol ; 44(11): 5485-5497, 2022 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-36354683

RESUMO

Pinus yunnanensis var. pygmaea demonstrates obvious loss of apical dominance, inconspicuous main trunk, which can be used as an ideal material for dwarfing rootstocks. In order to find out the reasons for the lack of apical dominance of P. pygmaea, endogenous phytohormone content determination by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and comparative transcriptomes were performed on the shoot apical meristem and root apical meristem of three pine species (P. massoniana, P. pygmaea, and P. elliottii). The results showed that the lack of CK and the massive accumulation of ABA and GA-related hormones may be the reasons for the loss of shoot apical dominance and the formation of multi-branching, the abnormal synthesis of diterpenoid biosynthesis may lead to the influence of GA-related synthesis, and the high expression of GA 2-oxidase (GA2ox) gene may be the cause of dwarfing. Weighted correlation network analysis (WGCNA) screened some modules that were highly expressed in the shoot apical meristem of P. pygmaea. These findings provided valuable information for identifying the network regulation of shoot apical dominance loss in P. pygmaea and enhanced the understanding of the molecular mechanism of shoot apical dominance growth differences among Pinus species.

13.
Artigo em Inglês | MEDLINE | ID: mdl-36383831

RESUMO

TiO2 crystals with different exposed facets are synthesized and modified facilely by depositing Fe(III) species. With more (101) facets exposed, the photoactivity of Fe-TiO2 is obviously enhanced with peroxymonosulfate (PMS) as oxidant. The degradation rate for 20 ppm Bisphenol A (BPA) on Fe-TiO2 (101) can achieve 0.219 min-1, ∼8.5 times faster than that of pure TiO2 under simulated sunlight irradiation. Photoelectrochemical measurements and density functional theory (DFT) calculations confirm that the interfacial charge transfer (IFCT) on Fe-TiO2 (101) is stronger than that on Fe-TiO2 (001) and a faster Fe(III)/Fe(II) transformation rate can be therefore achieved. As a result, the generation of ·OH and 1O2 will be accelerated with more (101) facets exposed, thus obtaining better photoactivity. Under the Fe-TiO2/PMS/Light system, BPA can be effectively degraded in a wide pH range or in the presence of multiple inorganic anions. After five cycles, 100% BPA can still be degraded within 60 min. The study provides new photocatalysts design strategy based on Fe(III)/Fe(II) redox for PMS based photocatalytic oxidation.

14.
Mol Cell ; 2022 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-36384136

RESUMO

Maintenance of energy level to drive movements and material exchange with the environment is a basic principle of life. AMP-activated protein kinase (AMPK) senses energy level and is a major regulator of cellular energy responses. The gamma subunit of AMPK senses elevated ratio of AMP to ATP and allosterically activates the alpha catalytic subunit to phosphorylate downstream effectors. Here, we report that knockout of AMPKγ, but not AMPKα, suppressed phosphorylation of eukaryotic translation elongation factor 2 (eEF2) induced by energy starvation. We identified PPP6C as an AMPKγ-regulated phosphatase of eEF2. AMP-bound AMPKγ sequesters PPP6C, thereby blocking dephosphorylation of eEF2 and thus inhibiting translation elongation to preserve energy and to promote cell survival. Further phosphoproteomic analysis identified additional targets of PPP6C regulated by energy stress in an AMPKγ-dependent manner. Thus, AMPKγ senses cellular energy availability to regulate not only AMPKα kinase, but also PPP6C phosphatase and possibly other effectors.

15.
Molecules ; 27(21)2022 Oct 26.
Artigo em Inglês | MEDLINE | ID: mdl-36364092

RESUMO

In this paper, inorganic oxide MgO nanoparticles-doped polymer dispersed liquid crystal (PDLC) films were made from a mixture of the prepolymer, SLC1717 liquid crystal, and MgO nanoparticles by the polymerization induced phase separation (PIPS) process. To observe the effect of MgO concentration, PDLC was dispersed with 0.2, 0.4, 0.6, and 0.8 wt.% MgO. Electro-optical properties of the films have been investigated using LCD parameter meter and Scanning Electron Microscope (SEM) at room temperature. It is established that MgO nanoparticles affect the microstructure of PDLC films significantly because of the formed agglomerates of MgO nanoparticles. Results show an improvement in the electro-optical properties and a decrease in the driving voltage for doped systems with MgO nanoparticles. When the doping amount of MgO is 0.8 wt.%, the threshold voltage (Vth) is reduced to about 7.5 V. Therefore, MgO-doped PDLC is expected to become an excellent choice in the field of energy-saving.

16.
Molecules ; 27(21)2022 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-36364386

RESUMO

To investigate the self-assembly behavior of π-conjugated ethynyl-pyrene discotic derivatives, a series of ethynyl-pyrene discotic materials were designed and synthesized by Sonogashira coupling reaction. The π-conjugated structures were characterized by 1H-NMR, IR spectroscopy, and elemental analysis. The optical properties of the discotic materials were examined by UV/Vis spectra and fluorescence emission spectra. The band gap of each compound was calculated by cyclic voltammetry with UV/Vis spectroscopy. Interestingly, the substituted groups in the four symmetrical positions did affect the self-assembly properties of as-resulted nano/micro structures. Under the same conditions, compounds 4a-4d could be self-assembled into different morphologies such as micro-tubes (for 4a), micro-wires (for 4b and 4c), and micro-grain crystals (for 4d). All of the results indicated that the discotic materials have the potential for optoelectronic applications.

17.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 34(9): 958-963, 2022 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-36377451

RESUMO

OBJECTIVE: To establish a stable fragment-induced penetrating liver injury model in landrace pigs and evaluate the characteristics of deep tissue injury. METHODS: According to the different positioning methods of aiming points, twelve healthy adult landrace pigs were divided into group A (the relative height "h" of the aiming point and the highest point of the body surface on the tracing line was set to 5 cm) and group B ("h" was set to 6 cm). Ultrasonography was used to determine the direction of fragment projection, and an experimental ballistic gun was used to project high-velocity fragments to cause injury to animals. The vital signs of the two groups were monitored, and whole blood cell count, blood gas analysis, and liver and renal function were tested. Damages to the liver and adjacent organs, as well as the amount of bleeding and survival time were analyzed. RESULTS: For the overall analysis of the two groups, the liver hit rate of fragment simulating projectiles was 100% (right anterior lobe and right lateral lobe injury), the hit rate of other organs in the abdominal cavity was 25% (3/12), and the incidence of hemothorax or pneumothorax was 8% (1/12). The wounds were mainly characterized by liver lacerations, with total or partial disconnection of the distal liver lobe. There was no significant difference in wound length and bleeding amount between groups A and B [wound length (cm): 9.8±1.7 vs. 11.2±3.8, bleeding amount (g): 597.0±477.1 vs. 1 032.0±390.3, both P > 0.05]. The depth of liver parenchymal laceration in group B with the aiming point closer to the anterior median line was significantly longer than that in group A (cm: 2.8±0.4 vs. 1.9±0.6, P = 0.015). Mean arterial pressure (MAP), pH value, residual arterial blood base (BE), hemoglobin (Hb) and hematocrit (HCT) levels decreased after the fragment-induced injury, and then reached a trough level [MAP (mmHg, 1 mmHg ≈ 0.133 kPa): 87.0±33.6, pH: 7.26±0.15, BE (mmol/L): -6.65±8.48, Hb (g/L): 9.86±1.10, HCT: 0.309±0.029, all P < 0.05] in the first hour. Blood lactate (Lac), lactate dehydrogenase (LDH) and aspartate aminotransferase (AST) levels increased over time, and reached a peak level [Lac (mmol/L): 10.21±4.40, LDH (U/L): 1 417.0±223.3, AST (U/L): 234.5 (162.5, 357.5), both P < 0.05] at 1 hour after injury. Pearson's correlation analysis showed that the total amount of bleeding was correlated with the depth of liver parenchyma laceration (r = 0.684,P = 0.014). The Kaplan-Meier survival curve showed that the 3 hours survival rate in group A was higher than that in group B, but the difference was not statistically significant [83.3% (5/6) vs. 33.3% (2/6), P > 0.05]. CONCLUSIONS: The high-velocity fragment-induced penetrating liver injury model established by striking landrace pigs closer to the anterior median line with fragment simulating projectiles is reproducible and the degree of damage is controllable, and the model is applicable to further relevant research of hepatic ballistic trauma.


Assuntos
Lacerações , Animais , Suínos , Fígado , Gasometria , Aspartato Aminotransferases , Pressão Arterial , Hemorragia
18.
ACS Omega ; 7(44): 39750-39759, 2022 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-36385851

RESUMO

Structural coloration of photonic crystals (PCs) is considered an ecological and environmental way to achieve colorful textiles. However, constructing PCs with obvious structural colors on traditional flexible yarns is still a great challenge. As a secondary structure that forms textiles, compared with fibers and fabrics, the yarns are rougher, hindering the construction of regular PCs. In this work, the flexible acrylic yarns with vivid structural colors, named PC-based structural color yarns, were prepared by constructing regular PCs via assembling poly(styrene-butyl acrylate-methacrylate) (P(St-BA-MAA)) colloidal microspheres on yarns. Specifically, the properties of P(St-BA-MAA) colloidal microspheres were investigated. The PCs with better structural stability and obvious structural colors were prepared by presetting the acrylic adhesive layer on yarns. Moreover, the color durability and color regulation methods of prepared PC-based structural color yarns were evaluated and discussed. The results showed that the P(St-BA-MAA) colloidal microspheres exhibited even particle sizes, excellent monodispersity, and a typical hard core-soft shell structure. And the glass-transition temperature (T g) of the microspheres was tested to be about 65.6 °C. The cationic acrylate regarded as a pretreatment agent could not only improve the combination between the PC layers and the yarns by acting as a "bridge" but also enhance the structural color effect by smoothing the yarn surface. The results showed that when the mass fraction of cationic acrylate was 3 wt %, the microspheres were beneficial to access regular PCs with obvious structural colors. The PCs with bright structural colors could be constructed on black acrylic yarns, and the colors of yarns were still bright after rubbing and washing tests, indicating that the prepared PC-based structural color yarns have good color fastness. Moreover, the color hue of PC-based structural color yarns could be regulated by adjusting the particle sizes and viewing angles. This study provides strategic support for the structural coloration of flexible materials.

19.
BMJ Glob Health ; 7(11)2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36328381

RESUMO

INTRODUCTION: Using nationally representative survey data from China and India, this study examined (1) the distribution and patterns of multimorbidity in relation to socioeconomic status and (2) association between multimorbidity and out-of-pocket expenditure (OOPE) for medicines by socioeconomic groups. METHODS: Secondary data analysis of adult population aged 45 years and older from WHO Study on Global Ageing and Adult Health (SAGE) India 2015 (n=7397) and China Health and Retirement Longitudinal Study (CHARLS) 2015 (n=11 570). Log-linear, two-parts, zero-inflated and quantile regression models were performed to assess the association between multimorbidity and OOPE for medicines in both countries. Quantile regression was adopted to assess the observed relationship across OOPE distributions. RESULTS: Based on 14 (11 self-reported) and 9 (8 self-reported) long-term conditions in the CHARLS and SAGE datasets, respectively, the prevalence of multimorbidity in the adult population aged 45 and older was found to be 63.4% in China and 42.2% in India. Of those with any long-term health condition, 38.6% in China and 20.9% in India had complex multimorbidity. Multimorbidity was significantly associated with higher OOPE for medicines in both countries (p<0.05); an additional physical long-term condition was associated with a 18.8% increase in OOPE for medicine in China (p<0.05) and a 20.9% increase in India (p<0.05). Liver disease was associated with highest increase in OOPE for medicines in China (61.6%) and stroke in India (131.6%). Diabetes had the second largest increase (China: 58.4%, India: 91.6%) in OOPE for medicines in both countries. CONCLUSION: Multimorbidity was associated with substantially higher OOPE for medicines in China and India compared with those without multimorbidity. Our findings provide supporting evidence of the need to improve financial protection for populations with an increased burden of chronic diseases in low-income and middle-income countries.


Assuntos
Gastos em Saúde , Multimorbidade , Adulto , Humanos , Estudos Longitudinais , Estudos Transversais , China/epidemiologia , Índia
20.
Mol Oncol ; 2022 Nov 21.
Artigo em Inglês | MEDLINE | ID: mdl-36408734

RESUMO

Epigenome-wide gene-gene (G×G) interactions associated with non-small cell lung cancer (NSCLC) survival may provide insights into molecular mechanisms and therapeutic targets. Hence, we proposed a three-step analytic strategy to identify significant and robust G×G interactions that are relevant to NSCLC survival. In the first step, among 49 billion pairs of DNA methylation probes, we identified 175,775 G×G interactions with PBonferroni ≤0.05 in the discovery phase of epigenomic analysis; among them, 15,534 were confirmed with P≤0.05 in the validation phase. In the second step, we further performed a functional validation for these G×G interactions at the gene expression level by way of a two-phase (discovery and validation) transcriptomic analysis, and confirmed 25 significant G×G interactions enriched in the 6p21.33 and 6p22.1 regions. In the third step, we identified two G×G interactions using the trans-omics analysis, which had significant (P≤0.05) epigenetic cis-regulation of transcription and robust G×G interactions at both the epigenetic and transcriptional levels. These interactions were cg14391855×cg23937960 (ßinteraction =0.018, P=1.87×10-12 ), which mapped to RELA×HLA-G (ßinteraction =0.218, P=8.82×10-11 ), and cg08872738×cg27077312 (ßinteraction =-0.010, P=1.16×10-11 ), which mapped to TUBA1B×TOMM40 (ßinteraction =-0.250, P=3.83×10-10 ). A trans-omics mediation analysis revealed that 20.3% of epigenetic effects on NSCLC survival were significantly (P=0.034) mediated through transcriptional expression. These statistically significant trans-omics G×G interactions can also discriminate patients with high risk of mortality. In summary, we identified two G×G interactions at both the epigenetic and transcriptional levels, and our findings may provide potential clues for precision treatment of NSCLC.

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