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1.
Food Chem ; 402: 134428, 2023 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-36303380

RESUMO

pH-sensitive films based on collagen, chitosan, ZnO-nanoparticles and mulberry extract (CC/ZnO/ME) were developed to monitor pork freshness. Fourier transform infrared analysis revealed that collagen, chitosan, ZnO-nanoparticles and ME interacted via hydrogen bonds. The UV-vis light barrier ability of CC/ZnO/ME film was gradually enhanced as increasing ME content from 0.5 to 2.0 % wt. Compared with CC film, the mechanical strength and DPPH radical free scavenging rate of the CC/ZnO/ME film had increased by 13.84 MPa and 58.74 %, respectively. CC/ZnO/ME1 and CC/ZnO/ME2 films exhibited better pH-sensitivity than CC/ZnO/ME3 film, with color visibly changing from red to blue/green in different buffer solutions (pH 3-12). When monitoring the freshness of pork stored at 4℃, the color of CC/ZnO/ME2 film changed from deep purple to blue when TVB-N content exceeded the maximum permissible limit (15 mg/100 g) on 6th day.


Assuntos
Quitosana , Morus , Carne de Porco , Carne Vermelha , Óxido de Zinco , Animais , Suínos , Morus/química , Quitosana/química , Embalagem de Alimentos , Carne Vermelha/análise , Concentração de Íons de Hidrogênio , Extratos Vegetais/química , Colágeno , Antocianinas/análise
2.
BMC Musculoskelet Disord ; 23(1): 951, 2022 Nov 03.
Artigo em Inglês | MEDLINE | ID: mdl-36329431

RESUMO

PURPOSE: To investigate the clinical efficacy and safety of a bone cement-injectable cannulated pedicle screw (CICPS) in the treatment of spondylolysis-type lumbar spondylolisthesis with osteoporosis. METHODS: A retrospective study was conducted on 37 patients (Dual-energy X-ray bone density detection showed different degrees of osteoporosis) with spondylolysis-type lumbar spondylolisthesis who underwent lumbar spondylolisthesis reduction and fusion using a new type of injectable bone cement screw from May 2011 to March 2015. Postoperative clinical efficacy was evaluated by the Visual Analogue Scale (VAS) scores and the Oswestry Disability Index (ODI). Imaging indexes were used to evaluate the stability of internal fixation of the devices 1, 3, 6, and 12 months after surgery and annually thereafter. The safety of the CICPS was assessed by the prevalence of intraoperative and postoperative complications. RESULTS: A total of 124 CICPS were implanted intraoperatively. Bone cement leakage occurred in 3 screws (2.42%), and no clinical discomfort was found in any patients. All 37 patients were followed up with an average follow-up time of 26.6 ± 13.4 months (12-58 months). In the evaluation of the clinical effects of the operation, the average postoperative VAS score of the patients decreased from 4.30 ± 1.58 before surgery to 0.30 ± 0.70 after surgery (P < 0.001), and the ODI decreased from 47.27% ± 16.97% before surgery to 3.36% ± 5.70% after surgery (P < 0.001). No screw was loose, broken or pulled out. CONCLUSION: CICPS is safe and effective in the treatment of spondylolysis-type lumbar spondylolisthesis complicated by osteoporosis.


Assuntos
Osteoporose , Parafusos Pediculares , Fusão Vertebral , Espondilolistese , Espondilólise , Humanos , Espondilolistese/complicações , Espondilolistese/diagnóstico por imagem , Espondilolistese/cirurgia , Cimentos Ósseos/efeitos adversos , Estudos Retrospectivos , Fusão Vertebral/métodos , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/cirurgia , Osteoporose/complicações , Osteoporose/diagnóstico por imagem , Osteoporose/cirurgia , Resultado do Tratamento
3.
Pharmaceuticals (Basel) ; 15(11)2022 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-36422552

RESUMO

Wound healing is one of the major challenges in the biomedical fields. The conventional single drug treatment has unsatisfactory efficacy, and the drug delivery effectiveness is restricted by the short retention on the wound. Herein, we develop a multifunctional adhesive hydrogel that can realize robust adhesion, transdermal delivery, and combination therapy for wound healing. Multifunctional hydrogels (CS-GA-S) are mixed with chitosan-gallic acid (CS-GA), sodium periodate, and centipede peptide-scolopin2, which slowly releases scolopin2 in the layer of the dermis. The released scolopin2 induces the pro-angiogenesis of skin wounds and enables excellent antibacterial effects. Separately, GA as a natural reactive-oxygen-species-scavenger promotes antioxidation, and further enables excellent antibacterial effects and wet tissue adhesion due to a Schiff base and Michael addition reaction for accelerating wound healing. Once adhered to the wound, the precursor solution becomes both a physically and covalently cross-linked network hydrogel, which has potential advantages for wound healing with ease of use, external environment-isolating, and minimal tissue damage. The therapeutic effects of CS-GA-S on wound healing are demonstrated with the full thickness cutaneous wounds of a mouse model. The significant improvement of wound healing is achieved for mice treated with CS-GA-S. This preparation reduces wound system exposure, prolongs local drug residence time, and improves efficacy. Accordingly, with the incorporation of scolopin2 into the shape-adaptive CS-GA hydrogel, the composite hydrogel possesses multi-functions of mechanical adhesion, drug therapy, and skin wound healing. Overall, such an injectable or sprayable hydrogel plays an effective role in emergency wound treatment with the advantage of convenience and portability.

4.
Exp Gerontol ; 171: 111990, 2022 Oct 27.
Artigo em Inglês | MEDLINE | ID: mdl-36397637

RESUMO

The present study aimed to compare the efficacy of different exercises on systolic blood pressure (SBP), diastolic blood pressure (DBP), and aortic pulse wave velocity (PWV) in postmenopausal women. We searched the China National Knowledge Infrastructure (CNKI), Wanfang database, Web of Science, PubMed, and Cochrane library databases, up to July 2022. The randomized controlled trials (RCTs) were selected following the inclusion criteria. We assessed study quality with the PEDro scale. The Stata software was used for statistical analysis. Twenty-three papers (26 RCTs) and 729 participants were included. Meta-analysis demonstrated that exercise decreased SBP (WMD = -6.74 mmHg, 95%CI: -9.08, -4.41, p = 0.000), DBP (WMD = -4.13 mmHg, 95%CI: -5.78, -2.48, p = 0.000) and aortic PWV (WMD = -0.79 m/s, 95%CI: -1.02, -0.56, p = 0.000). Aerobic exercise can significantly decrease SBP (WMD = -7.97 mmHg, 95%CI: -12.99, -2.60, p = 0.003) and DBP (WMD = -5.97 mmHg, 95%CI: -8.55, -3.39, p = 0.000). Resistance exercise can significantly decrease SBP (WMD = -5.62 mmHg, 95%CI: -9.00, -2.23, p = 0.001), DBP (WMD = -1.87 mmHg, 95%CI: -2.75, -0.99, p = 0.000) and aortic PWV (WMD = -0.67 m/s,95%CI: -0.98, -0.36, p = 0.000). Combined aerobic and resistance exercise can significantly decrease SBP (WMD = -5.42 mmHg, 95%CI: -10.17, -0.68, p = 0.025). The efficacy of mind-body exercise (Tai Chi/Yoga) on SBP, DBP, and aortic PWV were not obvious (p > 0.05). Exercise significantly improved SBP, DBP, and aortic PWV in postmenopausal women. Aerobic exercise decreased SBP and DBP. Resistance exercise decreased SBP, DBP, and aortic PWV. Additionally, further research is required to confirm the efficacy of mind-body exercise (Tai Chi/Yoga) on blood pressure and arterial stiffness.

5.
Opt Express ; 30(16): 28922-28931, 2022 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-36299078

RESUMO

Wide-angle and broadband antireflection (AR) coating is of the essence in modern optical systems in many fields, which has a great influence on the stray light and imaging quality. A simple and convenient manufacturing method is proposed to address this issue based on a composite coating combining the nano-tapered Al2O3•xH2O (AH) structure and high-low index thin film stack. The optical properties of nano-tapered AH structure at various thickness are first studied and modeled in optics by several homogeneous sub-layers with the graded equivalent index. The designed composite AR coatings are manufactured by vacuum deposition and wet etching subsequently in the hot deionized water. Compared to the common dielectric multilayer antireflection stack, the composite coating presents excellent AR performance. The measured average reflectance values of the double-side coated BK7 glass are as low as 0.40%, 0.41%, 0.56% and 3.13% in 400-1100nm band at angles of incidence (AOI) of 6°, 20°, 40°, and 60°, respectively, while the measured average transmittance at normal incidence increases up to 99.3%. Finally, the process reproductivity, environmental reliability test including long term storage, high temperature annealing and 85°C-85% relative humidity storage of the composite coatings are evaluated. The proposed AR scheme provides a low-cost, efficient, wide-angle and broadband AR coating for kinds of large-curvature components and complex surfaces in fields of consumer electronics, automotive, security, etc.

6.
Colloids Surf B Biointerfaces ; 219: 112825, 2022 Sep 06.
Artigo em Inglês | MEDLINE | ID: mdl-36088831

RESUMO

Pure fish skin collagen hydrogels as a wound dressing have lower thermodynamic stability than mammalian collagen and usually suffer from poor mechanical properties, weak degradation resistance and insufficient functionalities such as antioxidant and anti-inflammatory properties to meet clinical needs that limit its further application. Here, a silver carp skin collagen hydrogel is successfully constructed via the cross-linking of the laccase-protocatechuic aldehyde (LAC-PAL) and the structure of the hydrogel is further consolidated and strengthened by the interaction of PAL and Fe3+. In this collagen hydrogel system, Fe3+, acting as a second cross-linker, consolidates and enhances the stability of the hydrogel after LAC-PAL cross-linking. This cross-linking method improves the resistance to degradation with a reduction in its degradation rate from 89.45% to 38.66% and endows the hydrogel with antioxidant activity. The in vitro data show that the hydrogel promotes cell proliferation and adhesion exhibiting good biocompatibility. Animal experiments show that the hydrogel contributes to angiogenesis and improves inflammatory response in the early stages of wound healing, resulting in promoting wound healing. Altogether, this newly developed collagen hydrogel is expected to be applied in wound repair as a wound dressing.

8.
Nanoscale Adv ; 4(9): 2171-2179, 2022 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-36133450

RESUMO

Here, a series of Fe/N/C catalysts with different proportions and pyrolysis temperatures are prepared by co-pyrolysis of melamine with a γ-cyclodextrin metal-organic framework (γ-CD-MOF) containing iron(ii) phthalocyanine (FePc). Due to the restriction effect of the host and guest at the molecular level, γ-CD-MOF can effectively avoid the π-π stacking of FePc and restrain the agglomeration of Fe atoms during pyrolysis. The phases and structures of the catalysts are characterized, which proves that the obtained catalyst has a three-dimensional porous and internal cavity structure with abundant surface area (1055.317 m2 g-1) and Fe is atomically dispersed in nitrogen-doped carbon. The onset potential (0.988 V vs. RHE) and half-wave potential (0.846 V vs. RHE) of FePc@CD/M (1 : 20)-1000 are superior to those of a commercial 20% Pt/C catalyst. FePc@CD/M (1 : 20)-1000 also exhibits an approximately four-electron (3.84) transfer process, good stability and excellent methanol tolerance.

9.
Front Plant Sci ; 13: 958066, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36051293

RESUMO

Hydrogels have outstanding research and application prospects in the field of product design. Among them, the design and preparation of cellulose-based functional hydrogels derived from bamboo have attracted increasing research interest. Cellulose-based hydrogels not only have the skeleton function of hydrogels, but also retain excellent specificity, smart structural design, precise molecular recognition ability, and superior biocompatibility. Cellulose-based hydrogels show important application prospects in various fields, such as environmental protection, biomedicine, and energy. What's more, they are potentially viable for application in food packaging and plant agriculture, such as fertilizers release and crop production. Recently, researchers have extracted cellulose from bamboo and generated a variety of cellulose-based functional hydrogels with excellent properties by various cross-linking methods. In addition, a variety of multifunctional hybrid cellulose-based hydrogels have been constructed by introducing functional components or combining them with other functional materials, thus expanding the breadth and depth of their applications. Herein, we elaborate on advances in the field of cellulose-based hydrogels and highlight their applications in food packaging and plant agriculture. Meanwhile, the existing problems and prospects are summarized. The review provides a reference for the further development of cellulose-based hydrogels.

10.
11.
Molecules ; 27(18)2022 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-36144733

RESUMO

BACKGROUND: Various potential effect of drugs on alleviating diseases by regulating intestinal microbiome as well as the pharmaceutical excipients on gut microbiota has been revealed. However, the interaction between them is rarely investigated. METHODS: Histological analysis, immunohistochemistry analysis, enzyme-linked immunosorbent assay (ELISA) analysis, RT-qPCR, and 16S rRNA analysis were utilized to explore the effect mechanism of the five excipients including hydroxypropyl methylcellulose (HPMC) F4M, Eudragit (EU) S100, chitosan (CT), pectin (PT), and rheum officinale polysaccharide (DHP) on berberine (BBR) to cure UC. RESULTS: The combined BBR with PT and DHP group exhibited better therapeutic efficacy of UC with significantly increased colon length, and decreased hematoxylin-eosin (H&E) scores than other groups. Furthermore, the expression of tight junction ZO-1 and occludin in colon tissue were upregulated, and claudin-2 was downregulated. Ultimately, the serum content of tumor necrosis (TNF)-α, interleukin (IL)-1ß, and IL-6 was decreased. Moreover, the combined BBR with PT significantly promoted the restoration of gut microbiota. The relative abundance of Firmicutes and Lactobacillus was significantly increased by the supplement of PT and DHP, and the relative abundance of Proteobacteria was downregulated. CONCLUSIONS: Our study may provide a new perspective that the selection of pharmaceutical excipients could be a crucial factor affecting the drugs' therapeutic efficiency outcome.


Assuntos
Berberina , Quitosana , Colite Ulcerativa , Colite , Microbioma Gastrointestinal , Animais , Berberina/metabolismo , Quitosana/farmacologia , Claudina-2/metabolismo , Colite/patologia , Colite Ulcerativa/induzido quimicamente , Colite Ulcerativa/tratamento farmacológico , Colo/metabolismo , Sulfato de Dextrana/farmacologia , Modelos Animais de Doenças , Amarelo de Eosina-(YS) , Excipientes/farmacologia , Hematoxilina/metabolismo , Hematoxilina/farmacologia , Hematoxilina/uso terapêutico , Humanos , Derivados da Hipromelose/metabolismo , Interleucina-6/metabolismo , Camundongos , Camundongos Endogâmicos C57BL , Ocludina/metabolismo , Pectinas/farmacologia , RNA Ribossômico 16S/genética , RNA Ribossômico 16S/metabolismo
12.
Angew Chem Int Ed Engl ; 61(41): e202209441, 2022 10 10.
Artigo em Inglês | MEDLINE | ID: mdl-36002933

RESUMO

Tetra-ortho-substituted, heteroaryl and cyclic azobenzenes have emerged as three key strategies on morphology design of photoswitch to diversify controllability. Cyclic azobenzene is of particular utilization in photo-energy conversion due to rigid and ring-strain structure. Despite the well-recognized diazocine, the photo-switching properties of seven-membered cyclic azobenzenes (diazepines) have yet been exploited. Herein, we report a family of dibenzo[b,f][1,4,5]chalcogenadiazepines (DBChDs) and their T-type photo-switching nature with tunable relaxation rate. Based on experiments together with DFT calculations, we found that an unsymmetric 2-bithiophenyl-dibenzo[b,f][1,4,5]thiadiazepine exhibited an efficient response to 445 nm laser stimulation (quantum efficiency, ΦZ→E =0.71) with millisecond relaxation half-life (t1/2 =40 ms). Photo-energy transduction efficiency was also exceptionally high with 29.1 % converted into ring-strain energy mainly loaded on azo π-bond.


Assuntos
Compostos Azo , Luz , Compostos Azo/química
13.
Front Cardiovasc Med ; 9: 942485, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36017092

RESUMO

Background: Base excess (BE) represents an increase or decrease of alkali reserves in plasma to diagnose acid-base disorders, independent of respiratory factors. Current findings about the prognostic value of BE on mortality of patients with acute myocardial infarction (AMI) are still unclear. The purpose of this study was to explore the prognostic significance of BE for short-term all-cause mortality in patients with AMI. Methods: A total of 2,465 patients diagnosed with AMI in the intensive care unit from the Medical Information Mart for Intensive Care III (MIMIC-III) database were included in our study, and we explored the association of BE with 28-day and 90-day all-cause mortality using Cox regression analysis. We also used restricted cubic splines (RCS) to evaluate the relationship between BE and hazard ratio (HR). The primary outcomes were 28-day and 90-day all-cause mortality. Results: When stratified according to quantiles, low BE levels at admission were strongly associated with higher 28-day and 90-day all-cause mortality. Multivariable Cox proportional hazard models revealed that low BE was an independent risk factor of 28-day all-cause mortality [HR 4.158, 95% CI 3.203-5.398 (low vs. normal BE) and HR 1.354, 95% CI 0.896-2.049 (high vs. normal BE)] and 90-day all-cause mortality [HR 4.078, 95% CI 3.160-5.263 (low vs. normal BE) and HR 1.369, 95% CI 0.917-2.045 (high vs. normal BE)], even after adjustment for significant prognostic covariates. The results were also consistent in subgroup analysis. RCS revealed an "L-type" relationship between BE and 28-day and 90-day all-cause mortality, as well as adjusting for confounding variables. Meanwhile, Kaplan-Meier survival curves were stratified by combining BE with carbon dioxide partial pressure (PaCO2), and patients had the highest mortality in the group which had low BE (< 3.5 mEq/L) and high PaCO2 (> 45 mmHg) compared with other groups. Conclusion: Our study revealed that low BE was significantly associated with 28-day and 90-day mortality in patients with AMI and indicated the value of stratifying the mortality risk of patients with AMI by BE.

14.
J Hazard Mater ; 438: 129553, 2022 09 15.
Artigo em Inglês | MEDLINE | ID: mdl-35999727

RESUMO

Ammonia (NH3) and nitrous oxide (N2O) have been regarded as the typical secondary pollutants emitted from vehicles equipped with a three-way catalyst (TWC). MultiGas FT-IR Analyzer was applied to determine the outlet gas concentrations in the light-off experiments, in order to understand how different reaction conditions and catalyst aging affect the production of these two pollutants. It was found that N2O formation is favored by the existence of excess oxygen during NO reduction, whereas NH3 is readily formed within the lack of reactive oxygen species. Interestingly, the reduction of NO by H2 in presence of excess oxygen can also lead to NH3 formation when the active metal particles are large enough, which provides the rational explanation why the increased NH3 was emitted from older gasoline vehicles. The loss of the catalytically active sites and reducibility caused by thermal aging requires longer time to warm-up thereby favors the N2O and NH3 formation, which is the major reason for the higher CO, NOx, HC, N2O and NH3 emissions from the old gasoline vehicles than that of low-mileage gasoline vehicles.


Assuntos
Poluentes Atmosféricos , Amônia , Poluentes Atmosféricos/análise , Amônia/análise , Catálise , Gasolina , Óxido Nitroso , Oxigênio , Espectroscopia de Infravermelho com Transformada de Fourier
15.
Comput Intell Neurosci ; 2022: 8740978, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36035854

RESUMO

People's lives are undergoing tremendous changes with the development of the times. Compared with the past, people's pursuit of spiritual and cultural life also makes our education field usher in a huge development to adapt to the changes in the context of the times. But, at the same time, the development of labor education is gradually being downplayed by people, resulting in a series of problems such as people preferring comfort and not working. Aiming at this common problem, this paper will use the ant colony algorithm and particle swarm optimization algorithm in the computer intelligent algorithm to optimize the way of labor education. It includes the principle and basic process of the ant colony algorithm, the establishment of the mathematical model of the original ant colony algorithm, and the improved algorithm of the ant colony algorithm. The research results of the optimization method of labor education showed the following: when the number of ant colonies reaches 51, the number of iterations of the algorithm will be the least, and the corresponding shortest path is also the best solution; when the combination of pheromone intensity and volatility factor is 3, the optimal solution can be quickly found, and the algorithm inflection point of MMAS is 44.82. From the research results, it can be seen that the computer intelligent algorithm has a good choice for the optimization of labor education and can achieve a major breakthrough in the traditional model of labor education.


Assuntos
Algoritmos , Modelos Teóricos , Simulação por Computador , Computadores , Humanos , Feromônios
16.
J Clin Pathol ; 2022 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-35863885

RESUMO

AIMS: Deep-learning methods for scoring biomarkers are an active research topic. However, the superior performance of many studies relies on large datasets collected from clinical samples. In addition, there are fewer studies on immunohistochemical marker assessment for dermatological diseases. Accordingly, we developed a method for scoring CD30 based on convolutional neural networks for a few primary cutaneous CD30+ lymphoproliferative disorders and used this method to evaluate other biomarkers. METHODS: A multipatch spatial attention mechanism and conditional random field algorithm were used to fully fuse tumour tissue characteristics on immunohistochemical slides and alleviate the few sample feature deficits. We trained and tested 28 CD30+ immunohistochemical whole slide images (WSIs), evaluated them with a performance index, and compared them with the diagnoses of senior dermatologists. Finally, the model's performance was further demonstrated on the publicly available Yale HER2 cohort. RESULTS: Compared with the diagnoses by senior dermatologists, this method can better locate the tumour area and reduce the misdiagnosis rate. The prediction of CD3 and Ki-67 validated the model's ability to identify other biomarkers. CONCLUSIONS: In this study, using a few immunohistochemical WSIs, our model can accurately identify CD30, CD3 and Ki-67 markers. In addition, the model could be applied to additional tumour identification tasks to aid pathologists in diagnosis and benefit clinical evaluation.

17.
Food Chem ; 393: 133353, 2022 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-35679702

RESUMO

Five different phenolic acids were oxidized by laccase. The UV-vis and FTIR results of oxidized phenolic acids indicated the formation of quinones and the amount of quinones enhanced with the increased phenolichydroxylnumber of phenolic acids. Then the quinones were used to modify collagen film. The FTIR and X-ray photoelectron spectra indicated that covalent cross-linking had formed between the quinones and the -NH2 of collagen molecules. Collagen films after being cross-linked with the quinones exhibited better physicochemical properties including water vapor permeability, resistance to enzyme degradation, mechanical property and thermostability. And these properties were significantly improved with the increased phenolic hydroxyl number of phenolic acids. Besides, the introduction of the phenolic acids endowed collagen film good antioxidant and antibacterial capacities. These results indicated that collagen film cross-linked by laccase oxidized phenolic acids showed potential for application as active edible food packaging.


Assuntos
Filmes Comestíveis , Lacase , Colágeno/química , Embalagem de Alimentos/métodos , Lacase/química , Permeabilidade , Quinonas
18.
J Musculoskelet Neuronal Interact ; 22(2): 296-300, 2022 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-35642709

RESUMO

There are few reports of rhabdomyolysis caused by anticoagulants, and it is extremely rare for it to be caused by dabigatran etexilate. An 86-year-old female experienced sudden muscle weakness and pain, a significant increase in Creatine kinase, and renal impairment after oral administration of dabigatran etexilate for 3 weeks. The enhanced thigh MRI showed abnormal signal in multiple thigh muscle groups, indicating that the lesions should be considered inflammatory diseases. In conclusion, the possibility of rhabdomyolysis should be ruled out when muscle weakness and myalgia occur at the beginning of dabigatran etexilate treatment.


Assuntos
Dabigatrana , Rabdomiólise , Idoso de 80 Anos ou mais , Benzimidazóis/efeitos adversos , Dabigatrana/efeitos adversos , Feminino , Humanos , Debilidade Muscular , Piridinas/efeitos adversos , Rabdomiólise/induzido quimicamente , Rabdomiólise/diagnóstico por imagem
19.
Foods ; 11(12)2022 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-35741938

RESUMO

The aroma profile of sun-dried black tea (SBT) was identified by headspace solid-phase microextraction (HS-SPME) coupled with gas chromatography-mass spectrometry (GC-MS) and gas chromatography-olfactometry (GC-O). A total of 37 scents were captured by using the GC-O technique, and 35 scents with odor intensities ranging from 1.09 ± 1.93 to 9.91 ± 0.29 were identified. Twenty-one compounds were further identified as key odor-active compounds with odor activity values (OAVs) greater than or equal to one. These key odor-active compounds were restructured with their detected concentrations, and the aroma profile of the selected SBT sample was successfully imitated to a certain extent. An omission test was performed by designing 25 models and confirmed that (E)-ß-damascenone, ß-ionone, dihydro-ß-ionone, linalool, and geraniol were the key odor-active compounds for the aroma profile of SBT. Meanwhile, phenylethyl alcohol, (E)-2-decenal, hexanal, and methyl salicylate were also important to the aroma profile of SBT. This study can provide theoretical support for the improvement of the aroma quality of sun-dried black tea.

20.
Chem Commun (Camb) ; 58(45): 6542-6545, 2022 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-35579480

RESUMO

A multifunctional RhB-PLGM@CN nanoprobe was created, in which g-C3N4 played dual pivotal functions in photodynamic therapy (PDT) and monitoring of invasion-related MMP-9 by surface-enhanced Raman spectroscopy. Significantly, using this probe, PDT was found to inhibit the cell invasion in a glioblastoma multiforme cell line model by down regulation of MMP-9.


Assuntos
Fotoquimioterapia , Linhagem Celular Tumoral , Metaloproteinase 9 da Matriz , Fotoquimioterapia/métodos , Análise Espectral Raman/métodos
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