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1.
J Ethnopharmacol ; 264: 113322, 2021 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-32871236

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: The genus Melastoma consists of approximately 100 species distributed widely in tropical and subtropical countries, and Melastoma species are often used for medicinal purposes, such as treatment for bleeding, diarrhea, diabetes, and gynecological tumors by local people, mostly in Southeast Asian countries. AIM OF THE REVIEW: The present review summarizes the traditional uses, phytochemistry and pharmacology of species belonging to Melastoma to suggest further research strategies and to facilitate the exploitation of the therapeutic potential of Melastoma species for the treatment of human disorders. MATERIALS AND METHODS: Information related to the traditional uses, phytochemistry and pharmacological activities was systematically collected by searching for the word "Melastoma" in electronic databases, including SciFinder, Web of Science, PubMed, and Google Scholar, from Apr. 1968 until Dec. 2019. RESULTS: A systematic literature survey revealed that Melastoma spp. are widely distributed in southern Asia to northern Oceania and the Pacific Islands and are traditionally used to treat bleeding, diarrhea, swelling, and gynecological tumors. Approximately 142 compounds, including flavonoids, tannins, phenylpropanoids, organic acids, terpenoids, and steroids, have been reported from Melastoma spp. Different extracts have been evaluated for their pharmacological activities, including anti-inflammatory, hemostatic, anticoagulant, cytotoxic, antibacterial, antioxidant, hepatoprotective, gastroprotective and hypoglycemic activities. CONCLUSIONS: Melastoma spp. are popularly used in Southeast Asian countries as effective herbs and are rich in flavonoids, tannins and organic acids with valuable medicinal properties. However, additional studies of the chemical constituents and the mechanism-based pharmacological activities of many members of Melastoma are still needed for developing new plant-derived drugs. In addition, studies on the clinical safety and efficacy of Melastoma are also needed.


Assuntos
Etnofarmacologia/métodos , Medicina Tradicional/métodos , Melastomataceae , Compostos Fitoquímicos/uso terapêutico , Extratos Vegetais/uso terapêutico , Animais , Antibacterianos/isolamento & purificação , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Anticoagulantes/isolamento & purificação , Anticoagulantes/farmacologia , Anticoagulantes/uso terapêutico , Etnofarmacologia/tendências , Flavonoides/isolamento & purificação , Flavonoides/farmacologia , Flavonoides/uso terapêutico , Humanos , Medicina Tradicional/tendências , Compostos Fitoquímicos/isolamento & purificação , Compostos Fitoquímicos/farmacologia , Extratos Vegetais/isolamento & purificação , Extratos Vegetais/farmacologia
2.
Zhongguo Zhong Yao Za Zhi ; 45(12): 2792-2799, 2020 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-32627452

RESUMO

Cinnamomum cassis is one of the commonly used traditional Chinese medicines in China. Its genuine producing areas distribute in Guangdong and Guangxi provinces. As an important edible herb and export variety of China, the quality control and internationalization of quality standards of C. cassis is extremely significant. In the recent years, with the development of the cinnamon industry, relevant academic research and the upgrade of the international standards, it is necessary to summarize the quality-related progress of C. cassis. In the present review, the germplasm resources, specific quality marker(Q-marker) and quality standards of C. cassis were summarized on the basis of published research during the last 10 years.


Assuntos
Cinnamomum aromaticum , Cinnamomum , China , Cinnamomum zeylanicum , Medicina Tradicional Chinesa
3.
Spectrochim Acta A Mol Biomol Spectrosc ; 218: 206-212, 2019 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-30995578

RESUMO

Hydrogen sulfide (H2S) is a kind of gaseous signal molecule in many physiological processes. In order to detect H2S, a novel "turn on" fluorescent probe 6,12-dihydroxyperylene-1,7-dione (DPD) was designed and synthesized. The probe DPD is fluorescence silence, while the addition of H2S induces an obvious green fluorescence with an obvious color change from dark blue to yellow-green. The probe shows excellent selectivity, fast response (2.5min) and linear curve (0-90µM) in wide effective pH range (4-10). Competition experiments are also revealed in corresponding studies and the detection limit is 3.6µM. The response mechanism is proved to be the reduction of the probe by H2S, which is confirmed by 1H NMR. Furthermore, through the fluorescence turn-on signal toward H2S in Hela cells, probe DPD was successfully applied to monitor H2S in living Hela cells.


Assuntos
Corantes Fluorescentes/química , Sulfeto de Hidrogênio/análise , Perileno/análogos & derivados , Quinonas/química , Fluorescência , Corantes Fluorescentes/síntese química , Células HeLa , Humanos , Limite de Detecção , Microscopia Confocal , Imagem Óptica , Perileno/síntese química , Perileno/química , Quinonas/síntese química , Espectrometria de Fluorescência
4.
J Agric Food Chem ; 67(17): 4831-4838, 2019 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-30969762

RESUMO

Zijuan tea ( Camellia sinensis var. assamica), an anthocyanin-rich cultivar with purple leaves, is a valuable material for manufacturing tea with unique color and flavor. In this paper, four new phenylpropanoid substituted epicatechin gallates (pECGs), Zijuanins A-D (1-4), were isolated from Zijuan green tea by different column chromatography. Their structures were identified by extensive high resolution mass spectroscopy (HR-MS), nuclear magnetic resonance (NMR), and experimental and calculated circular dichroism (CD) spectroscopic analyses. Detection of the changes in fresh tea leaves collected from April to September and the final processed product by high performance liquid chromatography (HPLC)-HRMS suggested that production of compounds 1 and 2 may be enhanced by the processing procedure of Zijuan green tea. Additionally, 1-4 were proposed to be synthesized through interaction between the abundant secondary metabolite ECG and phenolic acids from tea leaves by two key steps of phenol-dienone tautomerism. 1 and 2 showed impressive activity in protecting SH-SY5Y cells against H2O2-induced damage at the concentration of 1.0 µM.


Assuntos
Camellia sinensis/química , Catequina/análogos & derivados , Fármacos Neuroprotetores/química , Fármacos Neuroprotetores/farmacologia , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Camellia sinensis/crescimento & desenvolvimento , Catequina/química , Catequina/farmacologia , China , Peróxido de Hidrogênio/toxicidade , Isomerismo , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Neurônios/efeitos dos fármacos , Folhas de Planta/química , Folhas de Planta/crescimento & desenvolvimento , Estações do Ano
5.
Spectrochim Acta A Mol Biomol Spectrosc ; 214: 487-495, 2019 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-30818149

RESUMO

In this work, we have designed and synthesized a dinitrobenzene-sulfonate tetrahydro[5]helicene (H-DNP) as an effective fluorescent probe for detection of hydrogen sulfide (H2S). Upon the addition of H2S, a significant fluorescence enhancement (75-fold) at 495 nm can be observed with a distinct color change from colorless to yellow. Additionally, H-DNP shows low background spectroscopic signal, large Stokes Shift up to ~140 nm, good sensitivity, rapid response time less than 2 min, low detection limit (48 nM) and high selectivity toward common bio-thiols (Cysteine, Homocysteine and Glutathione). Compared with the previous dinitrophenoxy tetrahydro[5]helicene, this probe has shorter response time and lower detection limit. Most importantly, this probe H-DNP has low toxicity to cells and excellent cell permeability, which can be applied to visualize H2S in living cells.


Assuntos
Corantes Fluorescentes , Sulfeto de Hidrogênio/metabolismo , Compostos Policíclicos , Corantes Fluorescentes/síntese química , Corantes Fluorescentes/química , Corantes Fluorescentes/farmacologia , Células HeLa , Humanos , Limite de Detecção , Microscopia de Fluorescência , Compostos Policíclicos/síntese química , Compostos Policíclicos/química , Compostos Policíclicos/farmacologia
6.
Talanta ; 196: 243-248, 2019 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-30683359

RESUMO

In this study, a new coumarin-based fluorescent and chromogenic dual channel probe (DC) was used for the selective detection of homocysteine (Hcy) over other amino acids, especially for cysteine (Cys) and glutathione (GSH). When Hcy is present in the solution, the remarkable fluorescence enhancement and obvious blue shift in UV-vis spectra can be observed. In addition, the color change from purple to yellow can be observed clearly by unaided eyes. This probe DC has fast response time, excellent sensitivity and selectivity to Hcy. A linear relationship exists between the ratio of emissions at 486 and 625 nm, and Hcy can be detected in a wide concentration range (0-200 µM). The signal-to-background ratio of fluorescence at 486 nm can reach 8.4, and the detection limit is calculated to be 3.5 µM. The response mechanism is proved to be the Michael addition reaction by Hcy. Preliminary results on cell imaging enable the practical application of Hcy tracing in living cells.

7.
J Agric Food Chem ; 65(14): 2999-3005, 2017 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-28339202

RESUMO

A novel acylated flavonol tetraglycoside, kaempferol 3-O-[(E)-p-coumaroyl-(1→2)][α-l-arabinopyranosyl-(1→3)][ß-d-glucopyranosyl (1→3)-α-l-rhamnopyranosyl(1→6)]-ß-d-glucopyranoside (camellikaempferoside C, 1), together with 2 flavonols and 18 flavone and flavonol glycosides (FGs) (2-21) was isolated from the green tea Lu'an GuaPian (Camellia sinensis L.O. Kuntze). Their structures were identified by spectroscopic and chemical methods. Four acylated FGs (1, 7, 8, 9) were found to inhibit the proliferation and differentiation of 3T3-L1 preadipocytes at concentrations of 25, 50, and 100 µM (P < 0.05). Furthermore, we established a rapid UPLC method to quantify nine FGs in six major processing types of tea. The results showed that dark tea had the highest amount of 20 (0.70 ± 0.017 mg/g) and black tea had the highest amount of 8 (0.09 ± 0.012 mg/g), whereas the amounts of 10 and 16 basically decreased with the increasing degree of fermentation and could contribute to the discrimination of different processing types of tea.

8.
Huan Jing Ke Xue ; 36(8): 3004-10, 2015 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-26592033

RESUMO

A pot experiment was carried out to explore the annual changes by bioremediation inoculated with 30 g Glomus versiorme in Pteris vittata L. The results showed that mycorrhizal colonization was the lowest in September 2013 (57.14%), and was the highest in March 2014 (75.20%), following the tendency firstly increasing and then decreasing. The dry biomass was markedly high in Gv than that in CK, especially in roots. The total U was significantly higher in Gv than that in CK, and was fixed predominantly into roots. The media in Gv showed less U than that in CK. It was absorbed the most to iron and manganese oxidable U and sulfide U, and each U species declined accompanying the time prolongation. In addition, bioconcentration factors were higher in Gv compared to those of CK, and both treatments were above 1. Positive relationship was found between mycorrhizal colonization and bioconcentration factors. Therefore, U uptake was enhanced inoculated by Gv, and the symbiont in arbuscular mycorrhizal fungus and Pteris vittata L. had a potential to remediate U polluted soil.


Assuntos
Micorrizas , Pteris/química , Poluentes Radioativos do Solo/análise , Urânio/análise , Biodegradação Ambiental , Biomassa , Raízes de Plantas/química , Pteris/microbiologia , Solo/química
9.
Int J Clin Exp Med ; 8(5): 7872-80, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26221343

RESUMO

OBJECTIVES: To discuss the associations of SNPs of TLR5, TLR9 and transduction molecules in MyD88 signaling pathway with systemic lupus erythematosus (SLE) risk in Zhuang and Han ethnics and to compare the difference between the two ethnics. METHODS: PCR and direct sequencing method were used to detect gene polymorphisms of TLR5, TLR9 and transduction molecules in MyD88 signaling pathway in 77 patients with SLE and 72 healthy controls, in order to explore their relationships with SLE incidence and compare the differences in genotypes and allele frequencies between groups. RESULTS: TLR5 rs5744168 gene polymorphism was unrelated with SLE susceptibility of Guangxi Zhuang and Han. Among the Han population, there was a statistically significant difference in TLR9 rs352140 genotype frequency between SLE group and control group (P = 0.043). In the Han and Zhuang populations, there were no significant differences in MyD88 rs7744 genotype and allele frequencies (all P > 0.05) between SLE group and control group; but there was a statistically significant difference in allele frequencies between the case group and the control group (P = 0.033). For TRAF6 rs5030472, GA + AA genotype frequency of Zhuang SLE group was significantly higher than that of control group and the difference was statistically significant (P = 0.006); an allele frequency was also significantly higher. IRF5 rs2004640 GG/TT genotype and the corresponding G allele frequencies of Zhuang SLE group were significantly higher than that of control group, with statistically significant differences (P = 0.008 and P = 0.000, respectively). CONCLUSION: TLR5 rs5744168 gene polymorphism may have no correlation with SLE susceptibility in Guangxi Zhuang and Han populations; TLR9 rs352140 gene polymorphism may be associated with SLE susceptibility in Guangxi Han population, while TRAF6 rs5030472 and IRF5 rs2004640 gene polymorphisms may relate to SLE susceptibility in Guangxi Zhuang population.

10.
Sci Rep ; 4: 5028, 2014 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-24848522

RESUMO

The study was to explore whether auricular acupressure (AA) can relieve anxiety during the period from trans-vaginal oocyte retrieval to the embryo transfer in IVF treatment and whether AA can improve the outcomes of IVF. 305 infertile patients with tubal blockage who were referred for IVF were included. The women were randomized into a control group with 102 cases, a Sham-AA group with 102 cases and an AA group with 101 cases. The anxiety levels were rated with Spielberger's State Trait Anxiety Inventory and the Amsterdam Preoperative Anxiety and Information Scale. Data of clinical pregnancy rate (CPR), implantation rate (IR) and live birth rate (LBR) were obtained. The levels of neuropeptide Y (NPY) and transforming growth factor alpha (TGF-alpha) in the follicular fluids were detected with ELISA. After treatment, in AA group, the levels of state anxiety, preoperative anxiety and need-for-information were significantly lower, whereas CPR, IR, LBR and NPY levels in the follicular fluids were markedly higher than Sham-AA group and control group. We concluded that AA could help to reduce anxiety levels associated with IVF and improves the outcomes of IVF partly through increasing the levels of NPY in the follicular fluids.


Assuntos
Terapia por Acupuntura , Ansiedade/terapia , Fertilização In Vitro , Pontos de Acupuntura , Adulto , Ansiedade/etiologia , Coeficiente de Natalidade , Estudos de Casos e Controles , Transferência Embrionária , Feminino , Seguimentos , Humanos , Técnicas In Vitro , Gravidez , Taxa de Gravidez , Prognóstico , Estudos Prospectivos
11.
J Zhejiang Univ Sci B ; 11(7): 512-5, 2010 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-20593516

RESUMO

QTLNetworkR is an R package that aims to provide a user-friendly and platform-independent tool to visualize quantitative trait loci (QTL) mapping results. The graphical functions of the QTLNetworkR are based upon lattice and grid packages, and the graphical user interface (GUI) of the QTLNetworkR is built upon RGtk2 and gWidgetsRGtk2 packages. Six functions are designed to help visualize marker interval, putative QTL, QTL-by-environment interactions, marker interval interactions, epistasis, and the predicted genetic architecture of complex traits. It is especially helpful in profiling results for multiple traits at multiple environments. The current version of QTLNetworkR is able to accept QTL mapping results from QTLNetwork, and it is ready for possible extensions to import results from some other QTL mapping software packages. In addition, we presented a QTL mapping result in rice (Oryza sativa) as an example to describe the features of QTLNetworkR.


Assuntos
Mapeamento Cromossômico/estatística & dados numéricos , Locos de Características Quantitativas , Software , Biologia Computacional , Epistasia Genética , Oryza
12.
Nanoscale Res Lett ; 4(7): 665-7, 2009 Mar 24.
Artigo em Inglês | MEDLINE | ID: mdl-20596519

RESUMO

We have successfully prepared anodized alumina membrane distributed Bragg reflector (DBR) using electrochemical anodization method. The transmission peak of this distributed Bragg reflector could be easily and effectively modulated to cover almost any wavelength range of the whole visible spectrum by adjusting anodization temperature.

13.
World J Gastroenterol ; 10(17): 2616-7, 2004 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-15300922

RESUMO

AIM: To analyze the clinicopathological features of Brunner's gland adenoma of the duodenum. METHODS: A rare case of Brunner's gland adenoma of the duodenum was described and related literature was reviewed. RESULTS: Brunner's gland adenoma of the duodenum appeared to be nodular hyperplasia of the normal Brunner's gland with an unusual admixture of normal tissues, including ducts, adipose tissue and lymphoid tissue. We suggested that it might be designated as a duodenal hamartoma rather than a true neoplasm. CONCLUSION: The most common location of the lesion is the posterior wall of the duodenum near the junction of its first and second portions. It can result in gastrointestinal hemorrhage and duodenal obstruction. Endoscopic polypectomy is a worthy treatment for benign Brunner's gland adenomas, as malignant changes in these tumors have never been proven.


Assuntos
Glândulas Duodenais/patologia , Duodenopatias/patologia , Duodeno/patologia , Hamartoma/patologia , Adenoma , Adulto , Humanos , Hiperplasia , Masculino
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