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Kardiologiia ; 59(12): 64-71, 2019 Dec 11.
Artigo em Russo | MEDLINE | ID: mdl-31849313


Resistant and refractory arterial hypertensions are two distinct clinical phenotypes of uncontrolled arterial hypertension (AH), which differ in their sensitivity to antihypertensive drug therapy. The review presents data obtained in clinical studies devoted to elucidating the involvement of disorders of neurohormonal status and renal function in the formation of resistant and refractory arterial hypertension, to and the development of new approaches to increasing the effectiveness of antihypertensive therapy in these patient's populations. The results of these studies have shown that in patients with uncontrolled arterial hypertension, despite prolonged intake ≥ 3 antihypertensive drugs with different mechanisms of action, including a diuretic, excess sodium reabsorption persists in the distal segments of nephron due to increased aldosterone activity and sympathetic nervous system hyperactivity. In this regard, special attention has been paid to the data of PATHWAY-2, PATHWAY-3 and ReHOT trials that in patients with resistant AH tested the clinical efficacy of spironolactone, amiloride, and antiadrenergic drugs bisoprolol, doxazosin and clonidine, suppressing activity of the sympathetic nervous system.

Anti-Hipertensivos/uso terapêutico , Hipertensão , Bisoprolol , Humanos , Hipertensão/tratamento farmacológico , Rim , Espironolactona
Vopr Med Khim ; 31(1): 79-82, 1985.
Artigo em Russo | MEDLINE | ID: mdl-3157268


Activities of hexokinase, phosphofructokinase and pyruvate kinase were studied in rat heart after emotional-painful stress and development of myocardium necrosis. The stress caused an activation of hexokinase and phosphofructokinase within 2 and 7 days, activity of pyruvate kinase was not altered. In myocardium necrosis developed after emotional-painful stress activity of phosphofructokinase was decreased within 2 days as compared with the animals, myocardial necrosis of which was produces using the routine procedures.

Glicólise , Hexoquinase/metabolismo , Miocárdio/enzimologia , Fosfofrutoquinase-1/metabolismo , Estresse Psicológico/enzimologia , Animais , Doença das Coronárias/enzimologia , Doença das Coronárias/etiologia , Ativação Enzimática , Humanos , Miocárdio/metabolismo , Miocárdio/patologia , Necrose , Ratos , Ratos Endogâmicos , Estresse Psicológico/complicações , Estresse Psicológico/metabolismo , Fatores de Tempo
Ukr Biokhim Zh (1978) ; 56(5): 536-40, 1984.
Artigo em Russo | MEDLINE | ID: mdl-6542265


It is established that the emotional stress preceding the acute development of ischemic necrosis of the myocardium is the most important condition of the glycogen metabolism disturbance in the central nervous and cardiovascular systems. The most considerable changes in the glycogen metabolism are detected in the heart.

Encéfalo/metabolismo , Doença das Coronárias/metabolismo , Glicogênio/metabolismo , Miocárdio/metabolismo , Estresse Psicológico/metabolismo , Animais , Doença das Coronárias/etiologia , Doença das Coronárias/patologia , Glicogênio/biossíntese , Humanos , Miocárdio/patologia , Necrose , Ratos , Ratos Endogâmicos , Estresse Psicológico/complicações , Fatores de Tempo