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1.
Medicine (Baltimore) ; 100(38): e27244, 2021 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-34559125

RESUMO

ABSTRACT: It has been reported that inflammation and immune system are related to prostate cancer. The neutrophil-to-lymphocyte ratio (NLR), as well as the platelet-to-lymphocyte ratio (PLR), have already been proposed as new indices to help diagnose prostate cancer (PCa). However, the monocyte-to-lymphocyte ratio (MLR) with regard to PCa has rarely been mentioned.To investigate the capability of the MLR to predict PCa.Patients who were pathologically diagnosed with PCa in our hospital and healthy control subjects who conformed to the inclusion criteria were enrolled. Patient data were recorded, including age, complete blood counts, blood biochemistry, and serum prostate-specific antigen (PSA) levels. The differences in these data between the groups were analyzed and the diagnostic value of the MLR was compared with PSA.Our study included a total of 100 patients with PCa and 103 healthy control subjects. Patients with PCa presented with a significantly higher NLR, MLR, and PLR compared to control subjects. However, the hemoglobin and lymphocyte levels were lower (P < .05) in PCa patients. The area under the curve (AUC) of PSA and ratio of free/total serum prostate-specific antigen were 0.899 (95% confidence interval [CI]: 0.857-0.942) and 0.872 (95% CI: 0.818-0.926), respectively, while the AUC of the MLR was 0.852 (95% CI: 0.798-0.906), which was higher than that of the NLR, PLR, and any other blood parameters. Additionally, the optimal cut-off value of the MLR for PCa was 0.264, with a specificity of 87.4% and a sensitivity of 72.0%. An evaluation of the diagnostic value of MLR + PSA gave an AUC of 0.936 (95% CI: 0.902-0.970). However, the AUC of MLR + PSA + f/tPSA was 0.996 (95% CI: 0.991-1.000). The diagnostic value of MLR + NLR + PSA gave an AUC of 0.945 (95% CI: 0.913-0.977), and the specificity is 0.971.PSA remains the most important diagnostic indicator. MLR combined with PSA and f/tPSA has the higher predictive value than PSA. It suggests that MLR may be another good predictive indicator of PCa. It can help reduce the clinical false positive rate.


Assuntos
Linfócitos , Monócitos , Valor Preditivo dos Testes , Neoplasias da Próstata/diagnóstico , Idoso , Idoso de 80 Anos ou mais , Humanos , Contagem de Leucócitos/métodos , Contagem de Leucócitos/estatística & dados numéricos , Masculino , Prognóstico , Neoplasias da Próstata/sangue , Estudos Retrospectivos
2.
J Craniofac Surg ; 32(2): 664-669, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33705005

RESUMO

OBJECTIVE: Unilateral complete cleft lip and palate (UCCLP) is associated with apparent nasal deformities before the cheilorrhaphy. The aim of this study was to determine whether preoperative correction techniques are effective in the treatment of nasal deformities in infant with unilateral UCCLP used by the systematic review and meta-analysis. METHODS: We searched Medline, Cochrane Library, EMBASE, PubMed, and Chinese BioMedical Literature Database (CBM) until January 31, 2019, to identify studies that compared the effectiveness of preoperative correction techniques in the treatment of nasal deformities in infant with UCCLP. Two authors individually extracted the data and performed the quality assessments. The height of nasal columella, the width of the affected side nasal ala and the inclination of the nasal columella were evaluated. RESULTS: Seven articles were incorporated into the systematic review, and 5 (274 participants) in the meta-analysis according to the inclusion criteria. The preoperative correction could increase the height of nasal columella in children with UCCLP [SMD: 2.64 mm; 95% confidence intervals (CI); (1.35 mm, 3.94 mm); P < 0.0001]. Moreover, the preoperative correction resulted in reduced width of the affected side nasal ala [SMD: -5.14 mm; 95% CI; (-8.96 mm, -1.31 mm); P = 0.008]; However, the evidence was insufficient to determine a significant effect on the inclination of the nasal columella [SMD: -3.48 degrees; 95% CI; (-7.56 degrees, 0.59 degrees); P = 0.09]. CONCLUSIONS: Preoperative correction for children with UCCLP can increase the height of nasal columella, reduce the width of the affected side nasal ala, improve the nasal symmetry, and reduce nasal deformity, however, no significant effect could be observed for the inclination of the nasal columella.


Assuntos
Fenda Labial , Fissura Palatina , Rinoplastia , Criança , Fenda Labial/cirurgia , Fissura Palatina/cirurgia , Humanos , Lactente , Septo Nasal/cirurgia , Nariz/cirurgia , Cuidados Pré-Operatórios , Resultado do Tratamento
3.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 37(5): 505-508, 2019 Oct 01.
Artigo em Chinês | MEDLINE | ID: mdl-31721498

RESUMO

OBJECTIVE: To study the clinical features and treatments of congenital submandibular duct dilatation. METHODS: Seven children with congenital submandibular duct dilatation from January 2008 to March 2018 were included in this study, whose average age was 5 months and 22 days. The clinical manifestations are unilateral swelling of the mouth floor. All seven children underwent sublingual gland resection, submandibular gland dilatation catheter resection, and catheter reroute under general anesthesia. Intraoperatively, the orifice of the submandibular gland was constricted and part of the catheter was dilated. RESULTS: All seven patients had good healing without swelling or cyst formation. CONCLUSIONS: Congenital submandibular duct dilatation occurs at a young age. Early diagnosis and treatment can help prevent further expansion of the catheter and avoid gland atrophy, feeding difficulty, and breathing obstruction. Simultaneous excision of the sublingual gland can avoid the formation of postoperative sublingual cyst.


Assuntos
Rânula , Ductos Salivares , Criança , Dilatação , Humanos , Lactente , Glândula Sublingual , Glândula Submandibular
4.
J Colloid Interface Sci ; 554: 650-657, 2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31351335

RESUMO

Transparent and flexible supercapacitors (TFSCs) could diversify the future wearable electronics owing to the fascinating optoelectronic and electrochemical performances. Herein, we report symmetric TFSCs assembled by reduced graphene oxide (rGO)@Ag nanowire/poly (ethylene terephthalate) (PET) transparent electrodes for capacitive storage, in which the interfacial structure of rGO film can be tuned by a facile freeze drying technique. The enlarged interlayer spacing of rGO film deteriorated the electronic migration derived from the loose layer structure, whereas about 33-52% of the areal capacitance of TFSCs was boosted as compared with the ones without freeze drying at the same transmittance. It is concluded that the enlarged inter-distance of rGO film could facilitate diffusion and transport of ions in the electrolyte, furthermore, the expanded rGO film could provide more interface to accommodate more ions for storage. The simulation results also confirmed the lower diffusion barrier and larger band gap of rGO with larger interlayer distance. The mechanically robust TFSCs exhibit the maximum energy density of 89.2 nWh cm-2, and the maximum power density of 4.63 µW cm-2 with remaining energy density of 41.1 nWh cm-2, as well as 3000 cyclic stability, demonstrating an efficient strategy toward high performance TFSCs.

5.
AMIA Annu Symp Proc ; 2019: 874-882, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-32308884

RESUMO

Nocturnal hypoglycemia is a serious complication of insulin-treated diabetes, which commonly goes undetected. Continuous glucose monitoring (CGM) devices have enabled prediction of impending nocturnal hypoglycemia, however, prior efforts have been limited to a short prediction horizon (~ 30 minutes). To this end, a nocturnal hypoglycemia prediction model with a 6-hour horizon (midnight-6 am) was developed using a random forest machine- learning model based on data from 10,000 users with more than 1 million nights of CGM data. The model demonstrated an overall nighttime hypoglycemia prediction performance of ROC AUC = 0.84, with AUC = 0.90 for early night (midnight-3 am) and AUC = 0.75 for late night (prediction at midnight, looking at 3-6 am window). While instabilities and the absence of late-night blood glucose patterns introduce predictability challenges, this 6-hour horizon model demonstrates good performance in predicting nocturnal hypoglycemia. Additional study and specific patient-specific features will provide refinements that further ensure safe overnight management of glycemia.


Assuntos
Automonitorização da Glicemia , Diabetes Mellitus Tipo 1/sangue , Hipoglicemia/prevenção & controle , Hipoglicemiantes/efeitos adversos , Insulina/efeitos adversos , Aprendizado de Máquina , Monitorização Ambulatorial , Área Sob a Curva , Glicemia , Diabetes Mellitus Tipo 1/tratamento farmacológico , Humanos , Hipoglicemia/induzido quimicamente , Hipoglicemia/diagnóstico , Hipoglicemiantes/uso terapêutico , Insulina/uso terapêutico , Modelos Biológicos , Curva ROC
6.
Langmuir ; 34(50): 15245-15252, 2018 12 18.
Artigo em Inglês | MEDLINE | ID: mdl-30428676

RESUMO

Transparent and flexible supercapacitors (TFSCs) are viable power sources for next-generation wearable electronics. The ingenious design of the transparent electrode determines the performance of TFSCs. A percolating film of a pillared graphene layer integrated with a silver nanowire network as the transparent electrode was prepared, by which TFSC devices exhibit a significantly improved performance contrastively. Under the condition of the same transmittance, about 27-72% improvement in the areal capacitance can be achieved. On the one hand, the pillars of carbon nanotube (CNT) were distributed in the graphene layer uniformly, enlarging the inner distance of adjacent graphene layers and providing an open structure for extra ion transport and storage of TFSCs. On the other hand, the introduced CNT could facilitate the electron transport at the direction perpendicular to the graphene basal plane, enhancing the electronic conductivity of the graphene layer. More importantly, the formed percolating film ensures an efficient transport of electron along with the silver nanowire when it encounters the obstacle within the graphene layer, resulting in a highly conductive electrode. The TFSC device with a good compatibility indicates a reliable practicability, which provides a facile route toward the design of high-performance TFSCs.

7.
J Craniomaxillofac Surg ; 44(11): 1786-1795, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27720276

RESUMO

PURPOSE: To evaluate postoperative variation trends of unilateral cleft lip by stages, and to analyze influential factors of nasolabial symmetry. MATERIALS AND METHODS: A total of 145 patients with unilateral cleft lip were treated by the modified Mohler or Tennison-Randall technique, and received routine anti-scarring treatment postoperatively. Photogrammetry was applied to respectively measure 5 indices by stages preoperatively, the first week (1 w), the third month (3 m), the sixth month (6 m), and the first year (1 y) postoperatively. Then we calculated the symmetry ratio and drew line charts. Student t tests were used for any group differences; linear regression analysis was used to examine which postoperative stage correlated best with the preoperative stage; cluster analysis was used to classify the severity of the cleft according to preoperative SRsn-cphi, which was used to predict the operative difficulty and to select an appropriate technique. RESULTS: The Mohler technique yielded a more symmetric result. With the Tennison-Randall technique, the alar base was more lateral and downward, and the lip height on cleft side seemed longer. A stable effect emerged around 1 year after surgery with both techniques. Conspicuous scars appeared at 3 months, most scars gradually fade at 6 months, and the total evolution took around 1 year. Scars from the Mohler technique fluctuated across a larger range. Preoperative SRsn-cphi of the two techniques had statistical significance and was adopted as the basis for cluster analysis. The critical value was 0.670. The Mohler technique attained an almost identical effect in each interval, whereas the Tennison-Randall technique was better in the interval that SRsn-cphi <0.670. CONCLUSIONS: Preoperative SRsn-cphi can be the evaluation index of severity; the modified Mohler technique is more broadly applicable to differences in severity than is the Tennison-Randall technique.


Assuntos
Fenda Labial/cirurgia , Lábio/cirurgia , Procedimentos Cirúrgicos Reconstrutivos/métodos , Fenda Labial/diagnóstico por imagem , Fenda Labial/patologia , Feminino , Humanos , Lactente , Lábio/diagnóstico por imagem , Lábio/patologia , Masculino , Fotogrametria , Estudos Retrospectivos , Índice de Gravidade de Doença , Resultado do Tratamento
8.
Nan Fang Yi Ke Da Xue Xue Bao ; 36(10): 1440-1443, 2016 Oct 20.
Artigo em Chinês | MEDLINE | ID: mdl-27777213

RESUMO

OBJECTIVE: To investigate the risk factors of the serious complications related with double-J ureteral stent placement following percutaneous nephrolithotomy (PCNL). METHODS: Clinical data were reviewed for 272 patients treated with PCNL and indwelling double-J stents between January, 2014 and April, 2016. The risk factors of serious complications were identified using univariate and multivariate logistic regression analysis. RESULTS: Serious complications of double-J ureteral stenting occurred in 63 patients (23.1%). Univariate and multivariate logistic regression analysis indicated that the ureter abnormalities (ß=1.735, P=0.000, OR=5.670), stent indwelling duration (ß=1.206, P=0.028, OR=3.340), gender (ß=0.895, P=0.016, OR=2.446), preoperative urinary tract infection (ß=0.849, P=0.020 , OR=2.338) and stent size (ß=0.847, P=0.011, OR=2.333) were all risk factors of serious complications related with the procedure. CONCLUSION: Male patients are exposed to a higher risk of serious complications following PCNL. Effective management of urinary tract infection and choice of appropriate stent size in cases of ureteral abnormalities help to reduce these complications. The double-J stent should be withdrawn as soon as possible in patients with good postoperative recovery.


Assuntos
Nefrostomia Percutânea , Stents/efeitos adversos , Ureter/cirurgia , Obstrução Ureteral/cirurgia , Feminino , Humanos , Pelve Renal , Modelos Logísticos , Masculino , Período Pós-Operatório , Fatores de Risco
9.
J Craniomaxillofac Surg ; 43(5): 663-70, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25957102

RESUMO

OBJECTIVE: The Mohler technique is one of the most popular methods to repair unilateral cleft lip (UCL) among the modified Millard methods, but it is still imperfect. We successfully designed a modified Mohler method based on geometric principles and observed its clinical effect. MATERIALS AND METHODS: Photogrammetry was performed in 56 patients who underwent UCL repair with the new technique. The symmetry ratios were assessed for sn-cphi, cphi-sbal, ch-sbal, ch-cphi, and vh preoperatively and 1 week after surgery, and were also compared with values in healthy control individuals. RESULTS: Preoperatively, all distances on the cleft side were shorter to different degrees. One week after surgery, results showed well-healed wounds with full, symmetric, and continuous vermilion. On the cleft side, the sn-cphi was 6.13% longer than the non-cleft, and the others were shorter (cphi-sbal: 5.904%; ch-sbal: 1.760%; ch-cphi: 6.234%). The symmetry ratios had differences of significance between preoperative values and those 1 week after surgery (p = 0.000, respectively). Moreover, the vermilion height on the cleft side was 1.026% thicker. When compared with the matched control group, with the exception of SRcphi-sbal (p = 0.072) and SRch-sbal (p = 0.139), there were significant differences (p = 0.000, respectively). All distances in the matched control group were not absolutely symmetric. CONCLUSIONS: The modified Mohler technique seems widely applicable, marking accurate, and less flexible.


Assuntos
Fenda Labial/cirurgia , Procedimentos Cirúrgicos Reconstrutivos/métodos , Estudos de Casos e Controles , Dissecação/métodos , Músculos Faciais/cirurgia , Feminino , Seguimentos , Humanos , Lactente , Freio Labial/cirurgia , Lábio/anatomia & histologia , Lábio/cirurgia , Masculino , Mucosa Bucal/cirurgia , Cavidade Nasal/cirurgia , Mucosa Nasal/cirurgia , Fotogrametria/métodos , Estudos Retrospectivos , Transplante de Pele/métodos , Retalhos Cirúrgicos/cirurgia , Resultado do Tratamento
10.
J Craniomaxillofac Surg ; 42(8): 1903-8, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25187377

RESUMO

PURPOSE: A novel, modified presurgical nasoalveolar molding (MPNAM) device with retraction screw was designed and used in patients with bilateral complete cleft lip and palate (BCCLP) to rapidly retract and centralize the protuberant and malpositioned premaxilla and correct the nasolabial and palatal deformities. The orthopedic effects and possible complications were evaluated. PATIENTS AND METHODS: Nine patients with BCCLP who met the inclusion criteria were selected. After the maxillary model was obtained, the new MPNAM device with retraction screw was designed and worn until cheilorrhaphy. Changes in local deformities and complications were observed continuously, and the orthopedic effect was evaluated. RESULTS: All patients quickly adapted to the MPNAM appliance, and the treatment was finished after 5-8 return visits. The columella was significantly prolonged, the nasal tip was elevated, and the collapsed nasal dome was obviously improved. Simultaneously, the premaxilla was rapidly retracted and rotated, and gradually centralized; the clefts were gradually reduced and closed, and a nearly normal dental arch was formed. Although there were some complications, the orthopedic treatment was continued until cheiloplasty. CONCLUSIONS: The MPNAM device with retraction screw can simultaneously correct nasolabial and palatal deformities and also rapidly retract and centralize the premaxilla.


Assuntos
Fenda Labial/terapia , Fissura Palatina/terapia , Maxila/patologia , Aparelhos Ortopédicos , Resinas Acrílicas/química , Materiais Biocompatíveis/química , Fenda Labial/cirurgia , Fissura Palatina/cirurgia , Arco Dental/patologia , Desenho de Equipamento , Feminino , Humanos , Recém-Nascido , Masculino , Nariz/patologia , Palato/patologia , Rotação , Aço Inoxidável/química , Stents
11.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 32(2): 145-9, 2014 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-24881208

RESUMO

OBJECTIVE: To evaluate the orthopedic effect of presurgical nasoalveolar molding (PNAM) devices on the palatal deformities in unilateral complete cleft lip and palate (UCCLP) patients. METHODS: Three groups with 19 patients each were studied. All samples in groups A and B were non-syndromic UCCLP children. Group A was treated with PNAM prior to operation. Group B was untreated prior to operation. Samples in group C were normally developed nose and lip palate infants aged three months. The orthotopic palate photos before and after PNAM treatment for group A, as well as pre-operative photos of groups B and group C, were taken and measured. All statistics were analyzed using SPSS 21.0. RESULTS: PNAM treatment significantly increased the AW, AC, and PA of UCCLP patients (P < 0.05), whereas CPW, CWA, CWAS, CWAH, PMD, and CA significantly decreased (P < 0.05). However, no significant difference was observed with the cases in group C (P < 0.05). The AW, CPW, CA, and PA of the patients in group B significantly increased compared with the cases in group A before PNAM treatment (P < 0.05). Multivariate analysis of variance indicated that TW had no statistically significant difference among the three groups (P > 0.05). CONCLUSION: PNAM treatment is a non-surgical early treatment for the effective improvement of palatal primary deformities in UCCLP patients.


Assuntos
Processo Alveolar , Fenda Labial , Criança , Fissura Palatina , Humanos , Lactente , Nariz , Cuidados Pré-Operatórios , Procedimentos Cirúrgicos Reconstrutivos
12.
Retina ; 33(5): 928-32, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23416511

RESUMO

PURPOSE: To evaluate flow rates and duty cycle for different sizes of ultra-high-speed pneumatic vitreous cutters. METHODS: A precision balance measured the mass of water and vitreous removed from a vial. Porcine vitreous was obtained within 12 hours of killed at a local slaughterhouse and kept at 4 °C. Twenty-, 23- and 25-gauge (n = 3 of each gauge) pneumatic cutters were tested at 0 (water), 1,000, 2,000, 3,000, 4,000, and 5,000 cuts per minute with aspiration levels of 100, 200, 300, 400, 500, and 600 mmHg. Frame-by-frame analysis of high-speed video was used to determine the duty cycle. RESULTS: Larger gauge cutters associated with higher aspiration levels produced greater vitreous and water flow rates (P < 0.05). As the cut rate increased, the vitreous flow rate increased (maximum flow at 5,000 cuts per minute) and the water flow rate decreased (P < 0.05). The duty cycle of the new-generation cutters decreased as cut speeds increased, using all 3 gauges (P < 0.001). Vitreous flow rates averaged 10 times less than water flow rates using the same cutter at the same settings. CONCLUSION: Ultra-high-speed vitreous cutters produce consistent vitreous and water flow rates across the tested range of cuts per minute and aspiration levels.


Assuntos
Microcirurgia/métodos , Vitrectomia/instrumentação , Corpo Vítreo/cirurgia , Animais , Desenho de Equipamento , Pressão , Suínos , Gravação em Vídeo , Água
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