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1.
Comput Intell Neurosci ; 2021: 7880215, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34630553

RESUMO

Predicting the information spread tendency can help products recommendation and public opinion management. The existing information cascade prediction models are devoted to extract the chronological features from diffusion sequences but treat the diffusion sources as ordinary users. Diffusion source, the first user in the information cascade, can indicate the latent topic and diffusion pattern of an information item to mine user potential common interests, which facilitates information cascade prediction. In this paper, for modelling the abundant implicit semantics of diffusion sources in information cascade prediction, we propose a Diffusion Source latent Semantics-Fused cascade prediction framework, named DSSF. Specifically, we firstly apply diffusion sources embedding to model the special role of the source users. To learn the latent interaction between users and diffusion sources, we proposed a co-attention-based fusion gate which fuses the diffusion sources' latent semantics with user embedding. To address the challenge that the distribution of diffusion sources is long-tailed, we develop an adversarial training framework to transfer the semantics knowledge from head to tail sources. Finally, we conduct experiments on real-world datasets, and the results show that modelling the diffusion sources can significantly improve the prediction performance. Besides, this improvement is limited for the cascades from tail sources, and the adversarial framework can help.


Assuntos
Aprendizagem , Semântica , Difusão
2.
J Oral Pathol Med ; 2021 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-34637577

RESUMO

BACKGROUND: Oral lichen planus (OLP) is a T-cell mediated chronic inflammatory disease with uncertain etiology. Mucosal associated invariant T (MAIT) cells and γδT cells are unconventional, innate-like T cells with immunoregulatory capacity. This study was aimed to investigate the potential effects of MAIT and γδT cells on the pathogenesis of OLP. METHODS: Circulating MAIT cells and γδT cells were identified using flow cytometry. Surface proteins including CD4, CD8, CD69, CD103, CD49d, programmed death-1 (PD-1) and its ligand PD-L1 were assessed. Cytokines containing interlukin (IL)-4, IL-17, interferon (IFN)-γ, granzyme B and tumor necrosis factor (TNF)-α released by MAIT and γδT cells were measured following PMA and ionomycin stimulation. RESULTS: Circulating MAIT and γδT cells were deficient in OLP. The percentage of CD4+ , CD69+ , CD103+ and PD-1+ MAIT cells was increased in OLP, while that of CD8+ and CD49d+ MAIT cells was decreased. The percentage of CD103+ , PD-1+ and PD-L1+ γδT cells was upregulated in OLP. Both the MAIT and γδT cells in OLP produced less IL-4 than controls. The granzyme B-producing MAIT cells was increased, while γδT cells secreting granzyme B and TNF-α were reduced in OLP. IL-17 and IFN-γ in OLP MAIT and γδT cells were not significantly different to that in controls. The frequency of OLP MAIT cells and the MAIT/γδT rate were positively associated with the disease severity. CONCLUSION: The deficient MAIT and γδT cells expressing functional proteins and releasing cytokines may play an immunoregulatory role in the pathogenesis of OLP.

3.
Biomed Pharmacother ; 143: 112233, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34649357

RESUMO

Spinal cord injury (SCI), one of the most devastating traumas, has caused long-term disability in millions of people worldwide. The pathophysiology of SCI primarily occurs in two stages classified as primary injury and secondary injury. Due to the rupture of axons and the apoptosis of neurons, patients lose their motor, sensory, and reflex functions, which also imposes a huge burden on families and society. However, traditional surgery does not facilitate neuronal regeneration. Although neural stem cells (NSCs) have the potential for multidirectional differentiation, the probability of differentiation into neurons and survival are still low. Surprisingly, the unique properties of nanotechnologies enable targeted drug delivery while reducing adverse reactions, assisting NSCs in differentiating into neurons. Here, recent studies on promising nanoscaffolds are highlighted, and their strengths and drawbacks are evaluated. Although the treatment of SCI remains fraught with challenges, the combination of nanoscaffolds and NSCs pave a promising road for SCI regeneration.

4.
Zhongguo Zhong Yao Za Zhi ; 46(12): 3150-3155, 2021 Jun.
Artigo em Chinês | MEDLINE | ID: mdl-34467707

RESUMO

In recent years, only a small number of new Chinese medicines have been approved for marketing, which has embodied the bottleneck in the development of the Chinese medicine industry. To tackle this problem, the National Medical Products Administration has issued a series of regulations and technical requirements. In the context of new regulations, this study deeply explored the research and development strategies of new Chinese medicines under the guidance of the new classification of drug registration, and discussed the key technical issues in the research and development.


Assuntos
Medicamentos de Ervas Chinesas , Preparações Farmacêuticas , China , Medicina Tradicional Chinesa , Pesquisa
5.
Artigo em Inglês | MEDLINE | ID: mdl-34546925

RESUMO

Cancer is not only a very aggressive but also a very diverse disease. Recent advances in high-throughput omics technologies of cancer have enabled biomedical researchers to have more opportunities for studying its multi-level biological regulatory mechanism. However, there are few methods to explore the underlying mechanism of cancer by identifying its multidimensional molecular regulatory modules from the multidimensional omics data of cancer. In this paper, we propose a sparse orthogonality-regularized joint non-negative matrix factorization (SOJNMF) algorithm which can integratively analyze multidimensional omics data. This method can not only identify multidimensional molecular regulatory modules, but reduce the overlap rate of features among the multidimensional modules while ensuring the sparsity of the coefficient matrix after decomposition. Gene expression data, miRNA expression data and gene methylation data of liver cancer are integratively analyzed based on SOJNMF algorithm. Then, we obtain 238 multidimensional molecular regulatory modules. The results of permutation test indicate that different omics features within these modules are significantly correlated in statistics. Meanwhile, the results of functional enrichment analysis show that these multidimensional modules are significantly related to the underlying mechanism of the occurrence and development of liver cancer.

6.
Surg Innov ; : 15533506211045318, 2021 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-34549663

RESUMO

BACKGROUND: Stomach cancer is the fourth most common type of cancer worldwide. TCN1 mainly encodes the vitamin B12 transporter, transcobalamin. TCN1 is a marker of gastrointestinal tumor progression, but the impact of TCN1 on survival is unclear. MATERIAL/METHODS: Gastrointestinal tumor records were reviewed and analyzed, clinicopathological data were summarized, immunohistochemical detection of TCN1 was performed again, and the protein expression in tumor tissue, non-tumor tissue, and lymph nodes was semi-quantitatively analyzed. Patients were followed up for 5 years to determine the 5-year survival rates. RESULTS: The strong immune reactivity of the TCN1 protein was significantly correlated with tumor invasion depth, regional lymph nodes, and a tumor diameter of >5 cm (Z = -2.531 and P = .016; Z = 3.785 and P < .001; Z = 2.541 and P = .049). Kaplan-Meier survival analysis showed that the total survival time of patients in the low-expression TCN1 group was significantly longer than that in the high-expression TCN1 group (P = .001; Table 2 and Figure 5). The mean survival time of all patients was 49.774 months (95% CI: 47.871-51.676; Table 4) and the 5-year overall survival rates were 73.3, 50.8, and 34.0%, respectively. Multivariate analysis revealed that regional lymph nodes (HR = 1.253; 95% CI: 1.031-1.747, P = .012), TCN1 immune expression status (HR = 2.707; 95% CI: 1.068-1.886, P = .016), and pTNM staging (HR = 2.293; 95% CI: 1.583-3.321; P = .001) were independent risk factors for poor survival. CONCLUSION: The high expression of TCN1 in gastric tumor tissues was found to be associated with the clinicopathological factors of patients, and the high expression of TCN1 was shown to indicate a poor clinical prognosis.

7.
Artigo em Inglês | MEDLINE | ID: mdl-34584001

RESUMO

Previous studies have reported that phosphodiesterase 10A (PDE10) is overexpressed in colon epithelium during early stages of colon tumorigenesis and essential for colon cancer cell growth. Here we describe a novel non-COX inhibitory derivative of the anti-inflammatory drug, sulindac, with selective PDE10 inhibitory activity, ADT 061. ADT 061 potently inhibited the growth of colon cancer cells expressing high levels of PDE10, but not normal colonocytes that do not express PDE10. The concentration range by which ADT 061 inhibited colon cancer cell growth was identical to concentrations that inhibit recombinant PDE10. ADT 061 inhibited PDE10 by a competitive mechanism and did not affect the activity of other PDE isozymes at concentrations that inhibit colon cancer cell growth. Treatment of colon cancer cells with ADT 061 activated cGMP/PKG signaling, induced phosphorylation of oncogenic ß-catenin, inhibited Wnt-induced nuclear translocation of ß-catenin, and suppressed TCF/LEF transcription at concentrations that inhibit cancer cell growth. Oral administration of ADT 061 resulted in high concentrations in the colon mucosa and significantly suppressed the formation of colon adenomas in the Apc+/min-FCCC mouse model of colorectal cancer without discernable toxicity. These results support the development of ADT 061 for the treatment or prevention of adenomas in individuals at risk of developing colorectal cancer. PREVENTION RELEVANCE: PDE10 is overexpressed in colon tumors whereby inhibition activates cGMP/PKG signaling and suppresses Wnt/ß-catenin transcription to selectively induce apoptosis of colon cancer cells. ADT 061 is a novel PDE10 inhibitor that shows promising cancer chemopreventive activity and tolerance in a mouse model of colon cancer.

8.
Artigo em Inglês | MEDLINE | ID: mdl-34423859

RESUMO

BACKGROUND: Although immune checkpoint blockade therapy has achieved great success in various types of cancers, studies on biliary tract cancer are limited. This study aimed to assess the efficacy and tolerability of immune checkpoint inhibitors (ICIs) combined with chemotherapy in Chinese patients with BTC. METHODS: We collected medical records of 130 pathologically diagnosed metastatic or recurrent BTC patients who had not received chemotherapy in the advanced stage. Eligible patients who received first-line chemotherapy ± ICIs were enrolled in the efficacy and safety analysis. We compared progression-free survival (PFS), overall survival (OS), objective response rate (ORR), and duration of response (DoR) between the ICI plus chemotherapy group and chemotherapy alone group. RESULTS: Of 90 enrolled patients, 45 received ICIs plus chemotherapy and 45 received chemotherapy. The median follow-up times were 18.7 and 19.6 months, respectively. The median PFS was 5.9 months (95% CI: 4.3-7.5) with ICIs plus chemotherapy, which was significantly longer than the 4.2 months (95% CI: 2.1-6.5) with chemotherapy (hazard ratio [HR] 0.62, 95% CI: 0.39-0.94; P = 0.0306). The median OS was 14.7 months (95% CI: 11.4-18.0) compared with 14.2 months (95% CI: 12.5-15.9) (HR 0.93; 95% CI: 0.57-1.50; P = 0.765). Grade 3 or 4 treatment-related adverse events were similar between these two groups (71.1% and 64.4%, respectively). CONCLUSION: Although first-line ICI therapy plus chemotherapy showed a significant improvement in the median PFS compared with chemotherapy in metastatic or recurrent BTC, the benefit did not translate into a statistically significant OS prolongation. The safety profile for ICIs plus chemotherapy was similar to chemotherapy alone.

9.
Curr Pharm Des ; 2021 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-34414867

RESUMO

BACKGROUND: Long noncoding RNA (lncRNA) fetal-lethal non-coding developmental regulatory RNA (FENDRR), a newly known lncRNA, has been reported to be abnormally expressed in diverse tumors. This review is focused on clarifying the mechanism of FENDRR to regulate the biological process of tumors, affirming its value as a target for tumor therapy. METHODS: The pathophysiological mechanism of FENDRR acting on tumors has been analyzed and summarized by reviewing PubMed. RESULTS: The expression of lncRNA FENDRR is abnormally altered in clinical cancers, promoting the malignant transformation of a variety of tumors, including colon cancer, cervical cancer, hepatocellular carcinoma, prostate cancer, Malignant melanoma, lung cancer, osteosarcoma, breast cancer, etc. Cellular processions, including proliferation, invasion, apoptosis and migration affected by FENDRR, have been revealed. CONCLUSION: Specific evidences for the involvement of LncRNA FENDRR in cancer regulatory processes suggest that FENDRR has the potential to be a biomarker or clinical therapeutic target for malignant tumors.

10.
Int J Pharm ; 607: 120972, 2021 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-34363916

RESUMO

Disulfiram copper complex [Cu(DDC)2] nanoparticles have been explored as promising anticancer agents but with concerns of toxic side effects. To improve tumor specificity and enhance anticancer efficacy, we developed a novel [copper sulfide nanoparticle (CuS NP) + disulfiram prodrug (DQ) micelle + near-infrared (NIR) laser] (CDL) combination therapy. DQ, a reactive oxygen species (ROS)-responsive prodrug, can be selectively activated at the tumor site with elevated ROS to release DDC and form Cu(DDC)2in situ. The CuS NP + NIR laser treatment can effectively increase the intra-tumor ROS levels and efficiently activate the DQ prodrug. The CDL therapy kills cancer cells through multiple mechanisms, including ROS amplification cascade and Cu(DDC)2 chemotherapy. NIR light-triggered tumor-specific "nontoxic-to-toxic" transition can significantly improve the specificity of anticancer effects and reduce systemic toxicity. Also, CDL therapy can effectively induce immunogenic cell death (ICD) and has the potential of eliciting antitumor immunity.


Assuntos
Nanopartículas , Neoplasias , Pró-Fármacos , Linhagem Celular Tumoral , Cobre , Combinação de Medicamentos , Morte Celular Imunogênica , Raios Infravermelhos , Neoplasias/tratamento farmacológico
11.
Curr Pharm Des ; 2021 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-34387158

RESUMO

BACKGROUND: Long non-coding RNAs (lncRNAs) has no protein-coding potential due to the lack of an apparent open reading frame. There is growing evidence that lncRNA DGCR5 has a vital regulatory role in human illnesses' pathological development, particularly in the digestive system's carcinogenesis and progression. Abnormal DGCR5 expression affects different cellular functions such as proliferation, aggression, and metastasis. This paper aims to probe into the pathophysiological functions and molecular mechanisms of DGCR5 in cancers of the digestive system. METHODS: This review summarizes and analyzes the biological functions and mechanisms of lncRNA DGCR5 in digestive system cancers occurrence. Relevant studies were conducted and reviewed by searching PubMed for articles with lncRNA DGCR5 and digestive system cancer as keywords in recent years. RESULTS: DCGR5, as a novel tumor-related lncRNA, is recently identified to be abnormally expressed in digestive system cancers, such as pancreatic ductal adenocarcinoma, pancreatic cancer, gastric cancer, gallbladder cancer, colorectal cancer, and hepatocellular carcinoma. The role played by DCGR5 is vital and varies in different digestive cancers. Taken together, aberrant expression of DCGR5 regulates the progression of digestive cancers by affecting cancer cell proliferation, aggression, metastasis, and drug resistance. CONCLUSION: LncRNA DGCR5 might be a viable marker or a promising therapeutic target in digestive system cancers.

12.
J Environ Manage ; 297: 113221, 2021 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-34293675

RESUMO

Heavy metal water pollution is an urgent global problem to be addressed. Copper ions are common toxic heavy metal pollutants in wastewater. In order to remove the excessive copper ions in wastewater, in this study, chicken bone charcoal was modified by sodium dodecyl sulfonate and combined with magnetic nanoparticles prepared with ferric chloride hexahydrate and ferrous sulfate heptahydrate to produce a high efficiency adsorbent. The characterization of the magnetically modified bone charcoal was analyzed by scanning electron microscopy, surface and porosity analyses, FTIR and thermogravimetric analysis. The optimal adsorption conditions of magnetically modified bone charcoal for Cu2+ were obtained through batch experiments. The highest removal rate and adsorption capacity of Cu2+ was 99.98% and 15.057 mg/g, respectively, when the pH was 3.0, adsorbent dosage was 0.2 g, initial concentration of the Cu2+ solution was 50 mg/L, and temperature was 25 °C. The adsorption process fitted well with the Langmuir isotherm and the pseudo-second-order kinetic model. The regeneration experiment indicated that M-SDS-BC-500 maintained a high removal rate after five repetitions. The results suggest that the adsorbent has wide application prospects.


Assuntos
Águas Residuárias , Poluentes Químicos da Água , Adsorção , Carvão Vegetal , Cobre/análise , Concentração de Íons de Hidrogênio , Íons , Cinética , Fenômenos Magnéticos , Mineração , Poluentes Químicos da Água/análise
13.
Curr Pharm Des ; 2021 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-34225608

RESUMO

BACKGROUND: As we all know, long non-coding RNA (lncRNA) affects tumor progression, which has caused a great upsurge in recent years. It can also affect the growth, migration, and invasion of tumors. When we refer to the abnormal expression of lncRNA, we will find it associated with malignant tumors. In addition, lncRNA has been proved to be a key targeted gene for the treatment of some diseases. PART1, a member of lncRNA, has been reported as a regulator in the process of tumor occurrence and development. This study aims to reveal the biological functions, specific mechanisms, and clinical significance of PART1 in various tumor cells. METHODS: Through the careful search of PUBMED, the mechanisms of the effect of PART1 on tumorigenesis and development are summarized. RESULTS: On the one hand, the up-regulated expression of PART1 plays a tumor-promoting role in tumors, including lung cancer, prostate cancer, bladder cancer and so on. On the other hand, PART1 is down-regulated in gastric cancer, glioma and other tumors to play a tumor inhibitory role. In addition, PART1 regulates tumor growth mainly by targeting microRNA such as miR-635, directly regulating the expression of proteins such as FUS/EZH2, affecting signal pathways such as the Toll-like receptor pathway, or regulating immune cells. CONCLUSION: PART1 is closely related to tumors by regulating a variety of molecular mechanisms. In addition, PART1 can be used as a clinical marker for the early diagnosis of tumors and plays an important role in tumor-targeted therapy.

14.
Curr Med Chem ; 2021 Jul 25.
Artigo em Inglês | MEDLINE | ID: mdl-34313198

RESUMO

BACKGROUND: Long non-coding RNAs (lncRNA) have influenced numerous biology processes, which has provoked great interest. Not only that, LncRNA DUXAP8 mediates tumorigenesis by affecting the activity of miRNAs, signaling pathways, and oncogene. METHODS: The functions of DUXAP8 have been summarized by reading relevant articles on PubMed. RESULTS: lncRNA DUXAP8 acts oncogene in most tumors. The abnormal over-expression is associated with the proliferation, invasion, migration, anti-autophagy of tumors. DUXAP8 exerts promotion on Akt / mTOR signaling pathway, facilitating the occurrence of tumors. Furthermore, DUXAP8 affects the activity of miRNAs and proteins, showing its significant potential as a therapeutic target in human cancers. CONCLUSION: LncRNA DUXAP8 has been identified as an indispensable therapeutic target of the tumors, providing clinical treatment plans.

15.
J Environ Manage ; 296: 113224, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34271349

RESUMO

There are a lot of coal cinder and dust in the development of coal resource-based cities. Improper handling will cause dust flying, which has a great impact on urban residents and the environment. The purpose of this research is to follow the principle of waste recycling, to use waste shrimp shells to extract chitosan as a raw material, to carry out graft polymerization with acrylic acid and polyvinyl alcohol-1788, and to carry out amidation crosslinking reactions with ethylenediamine tetraacetic acid to produce products. The results showed that the degree of deacetylation of chitosan reached 85% with the optimized extraction method, which greatly shortened the process cycle. Through orthogonal experiments and osmotic wetting experiments, the best preparation process was determined. The reaction process, structure of the product and adhesive structure of the solidified layer were analyzed by FTIR, XPS and SEM. The thermal stability of the product was analyzed by thermogravimetry. Relevant performance tests showed that the product had good adhesion with dust, the hardness of the solidified layer could reach 98 HA, and the dust fixation rate was 92.67% when the wind speed was 15-18 m/s. It has the advantage of circulating dust fixation, which improves the utilization rate of resources.


Assuntos
Minas de Carvão , Carvão Mineral , Cidades , Poeira/análise , Vento
16.
J Am Chem Soc ; 2021 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-34270228

RESUMO

Cyclopenta[b]thiopyran, isomeric to benzo[b]thiophene while isoelectronic to azulene, is involved as a building block to construct soluble organic semiconductors for field-effect transistors. Two series of angular-shaped heteroarenes based on cyclopenta[b]thiopyran, that is, Cn-SS (n = 4, 6, 8, 10) with different linear alkyl groups and C8-SS-Clm (m = 2, 3, 4) with chlorides substituted at different positions, have been straightforward synthesized. The obtained seven S-heteroarenes exhibit intriguing and similar photophysical and electrochemical properties, such as near-infrared absorption and high-energy levels of the highest occupied molecular orbitals. Nevertheless, the S-heteroarenes with identical π-conjugated skeletons demonstrate completely different molecular packing structures, which is proofed to be the key determinate factor for the charge carrier mobilities. Upon the engineering of the pendant alkyl lengths, the highest hole mobility in the Cn-SS series is achieved for C8-SS (1.1 cm2 V-1 s-1) with moderate alkyl length. The further incorporation of chlorides on C8-SS results in the shortened intermolecular H···S contacts and the interplane distances. Most interestingly, when chlorine-containing chloroform and chlorobenzene are used as crystallization solvents, single crystals of C8-SS-Clm with different packing structures are produced owing to the intermolecular interactions among the solute and solvent molecules. Upon further engineering of the chlorination position and the crystallization solvent, the maximum hole mobility in the ambient air improves to 2.7 cm2 V-1 s-1 for C8-SS-Cl2 crystallized from chlorobenzene, suggesting that the introduction of the accessible chlorides is a feasible pathway to engineering the crystal structures and controlling the charge transport characteristics.

17.
J Hazard Mater ; 420: 126545, 2021 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-34274807

RESUMO

Sulfated CeO2 cubes were prepared by the impregnation of CeO2 cubes by ammonium sulfates, and further evaluated in selective catalytic reduction of NOx with ammonia (NH3-SCR). Catalytic activity tests indicated that NOx reduction conversions and N2 selectivity of sulfated CeO2 cubes could be significantly improved compared to pure CeO2 cubes. The synthesized sulfated CeO2 cubes were further characterized by atom-resolved high angle annular dark-field (HAADF) imaging, Fourier-transform infrared spectroscopy (FTIR) by pyridine adsorption, and temperature-programmed reduction by H2 (H2-TPR). The characterization results showed that sulfates were primarily dispersed through the corners, edges, and surfaces of CeO2 cubes, and did not significantly affect the crystal structures of CeO2 cubes. Sulfation treatment could create and strengthen Brønsted acid sites originated from the protons on surface sulfates, further facilitating ammonia adsorption and activation. The kinetic data indicated that the apparent reaction order of NO, O2, and NH3 was 0.95 to 1.01, -0.01 to 0.00, and -0.18 to -0.15, respectively. It could speculate that gaseous phase NO involving in NO catalytic oxidation was the rate-determining step over sulfated CeO2 cubes for NH3-SCR reaction. The presence of NH3 slightly inhibited the SCR reaction rate due to the competitive adsorption blocking NO oxidation sites.

18.
Brain Imaging Behav ; 2021 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-34296381

RESUMO

PURPOSE: The present study combined resting-state functional connectivity (FC) and Granger causality analysis (GCA) to explore frontostriatal network dysfunction in unilateral acute tinnitus (AT) patients with hearing loss. METHODS: The participants included 42 AT patients and 43 healthy control (HC) subjects who underwent resting-state functional magnetic resonance imaging (fMRI) scans. Based on the seed regions in the frontostriatal network, FC and GCA were conducted between the AT patients and HC subjects. Correlation analyses were used to examine correlations among altered FC values, GCA values, and clinical features in AT patients. RESULTS: Compared with HCs, AT patients showed a general reduction in FC between the seed regions in the frontostriatal network and nonauditory areas, including the frontal cortices, midcingulate cortex (MCC), supramarginal gyrus, and postcentral gyrus (PoCG). Using the GCA algorithm, we detected abnormal effective connectivity (EC) in the inferior occipital gyrus, MCC, Cerebelum_Crus1, and PoCG. Furthermore, correlations between disrupted FC/EC and clinical characteristics, especially tinnitus distress-related characteristics, were found in AT patients. CONCLUSIONS: Our work demonstrated abnormal FC and EC between the frontostriatal network and several nonauditory regions in AT patients with hearing loss, suggesting that multiple large-scale network dysfunctions and interactions are involved in the perception of tinnitus. These findings not only enhance the current understanding of the frontostriatal network in tinnitus but also serve as a reminder of the importance of focusing on tinnitus at an early stage.

19.
Sci Total Environ ; 792: 148290, 2021 Oct 20.
Artigo em Inglês | MEDLINE | ID: mdl-34153752

RESUMO

Understanding changes in ecosystem services and their drivers is important for effective riparian ecosystem conservation and restoration. In the study, changes in water-related ecosystem services (soil conservation, water purification, and water yield) from 2007 to 2015 in Liaohe River Reserve, China were analyzed using the Integrated Valuation of Ecosystem Services and Trade-offs model. Impacts of landscape patterns on ecosystem services for different stages of restoration, i.e., farmland abandonment and natural succession stages were determined by stepwise regression analysis, respectively. The results showed that landscape fragmentation, landscape diversity, farmland fragmentation and grassland aggregation increased at the farmland abandonment stage. Landscape aggregation and diversity increased, whereas farmland fragmentation and grassland fragmentation decreased at the natural succession stage. Water-related ecosystem services improved since farmland abandonment, but water yield decreased from 1.57 × 106 m3 to 1.47 × 106 m3 at natural succession stage from 2011 to 2015. Water yield dynamics both at farmland abandonment and natural restoration stages were not significantly associated with landscape metrics. Dynamics of soil retention and water purification services at the farmland abandonment stage were significantly affected by landscape patch numbers, farmland division, and grassland aggregation. Interspersion and juxtaposition between different patch types, farmland edge density, grassland division, and grassland aggregation played significant roles in the dynamics of soil retention and water purification services at the natural restoration stage. The results provide scientific guidance for riparian management at the landscape scale to better restore water-related ecosystem services.


Assuntos
Ecossistema , Rios , China , Solo , Água/análise
20.
Artigo em Inglês | MEDLINE | ID: mdl-34133272

RESUMO

It is appealing but challenging to achieve real-time deep neural network (DNN) inference on mobile devices, because even the powerful modern mobile devices are considered as '`resource-constrained'' when executing large-scale DNNs. It necessitates the sparse model inference via weight pruning, i.e., DNN weight sparsity, and it is desirable to design a new DNN weight sparsity scheme that can facilitate real-time inference on mobile devices while preserving a high sparse model accuracy. This paper designs a novel mobile inference acceleration framework GRIM that is General to both convolutional neural networks (CNNs) and recurrent neural networks (RNNs) and that achieves Real-time execution and high accuracy, leveraging fine-grained structured sparse model Inference and compiler optimizations for Mobiles. We start by proposing a new fine-grained structured sparsity scheme through the Block-based Column-Row (BCR) pruning. Based on this new fine-grained structured sparsity, our GRIM framework consists of two parts: (a) the compiler optimization and code generation for real-time mobile inference; and (b) the BCR pruning optimizations for determining pruning hyperparameters and performing weight pruning. We compare GRIM with Alibaba MNN, TVM, TensorFlow-Lite, a sparse implementation based on CSR, PatDNN, and ESE (a representative FPGA inference acceleration framework for RNNs), and achieve up to 14.08x speedup.

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