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1.
Int J Ophthalmol ; 15(4): 628-634, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35450183

RESUMO

AIM: To evaluate the accuracy, efficiency, and reliability of a handheld infrared eccentric autorefractor (hICA) with artificial intelligence (AI) by comparing its refraction measurements to those recorded using hICA and a clinical table-mounted automatic refractor (TAR). METHODS: A cross-sectional study using three optometers, including hICA with or without AI and TAR, for refractometry of adults (aged 19-49 years old) with no signs of ocular disease or trauma in the absence of cycloplegia. Right and left eye refraction data were recorded, including the spherical equivalent (SE), diopter of spherical power (DS), diopter of cylindrical power (DC) decomposed into vectors J0 and J45, and measurement times. To avoid analytical difficulties associated with the interdependence of observations between eyes from the same individual, the Generalized Estimation Equation was used to compare the SE, DS, J0 and J45 measurements, and the times thereof, among the different groups. The intraclass correlation coefficient (ICC) and Spearman's rank correlation coefficient were used to evaluate correlations among the measurements recorded by the three different instruments. Bland-Altman were used to analyze the precision of the equipment by the agreement. RESULTS: A total of 70 patients (140 eyes; mean age: 31.37y; range: 19-49y) were assessed using refractometry. In a brightly lit environment, there was no significant difference between the mean SE recorded using TAR and that recorded using hICA with AI or without AI (both P>0.05). In an intense-light environment, hICA equipped with AI showed a better detection rate than without AI. Light intensity had a greater effect on dioptric measurements recorded using hICA without AI (P<0.001) than on those recorded using the one equipped with AI (P<0.05). Measurement times varied significantly between the different light intensities and instruments (P<0.05). CONCLUSION: For the normal human eyes, AI may improve the accuracy, efficiency, and reliability of measurements recorded using hICA in various light environments.

2.
Environ Res ; 211: 112916, 2022 Feb 26.
Artigo em Inglês | MEDLINE | ID: mdl-35231457

RESUMO

Radionuclides of 60Co often encountered in the fields of radiation therapy, medical preparation, and equipment sterilization, which have been considered fatal. Therefore, developing efficient and irradiation-stable adsorbents for the removal of 60Co in wastewater is urgently needed. An irradiation-stable fibrous adsorbent was fabricated through the surface functionalization of collagen fibers (CFs) by polyethyleneimine (PEI) and hydrated titanium oxide (TiO) (PEI-TiO-CFs). PEI-TiO-CFs, including their adsorption performance and irradiation stability, were systematically investigated. Results showed that PEI-TiO-CFs exhibit a maximum adsorption capacity of 0.5575 mmol g-1. In addition, the adsorption capacity of PEI-TiO-CFs only demonstrated a slight decrease in the selectivity investigation of Co2+ mixed with another coexisting ion, such as Na+, K+, and NO3-, Cl-. Furthermore, breakthrough point of PEI-TiO-CFs in column is high at 80 BV (bed volume) and the PEI-TiO-CF column can be mostly regenerated using 12 BV of Na2EDTA solution. Excellent irradiation stability of PEI-TiO-CFs was confirmed by the maintained morphology and adsorption capacity after irradiation at 350 kGy of 60Co γ-ray. Results indicated that PEI-TiO-CFs are an effective adsorbent for radioactive cobalt removal from aqueous solutions.

3.
Int J Ophthalmol ; 15(3): 510-514, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35310066

RESUMO

With the increasing prevalence in recent years, myopia has become an essential global health concern. In most instances, an increased axial length of the eye is the structural cause of nearsightedness. The scleral remodeling, primarily dependent on the scleral extracellular matrix (ECM) changes, is significantly linked to eye lengthening. Scleral remodeling plays a critical function in the incidence and progression of myopia. This mini-review will focus on recent research progress of scleral remodeling in the hope of providing new ideas for the prophylaxis and treatment of myopia.

4.
Curr Eye Res ; 47(3): 468-476, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34766525

RESUMO

PURPOSE: The aim of this study was to characterize the regulatory role of microRNA-29a (miR-29a) in myopia, providing support for potential biomarkers and new therapeutic targets of myopia in humans. METHODS: The miR-29a expression level was detected in the aqueous humor and peripheral blood plasma of 21 high myopic patients and eight cataract control patients using quantitative polymerase chain reaction. iTRAQ analysis of proteomes was conducted to show the regulatory effect of miR-29a on human scleral fibroblasts (SFs) cultured in vitro. We also assessed proliferation, migration, and collagen I synthesis in SF cells, mediated by miR-29a. RESULTS: MiR-29a expression was significantly higher in the aqueous humor of highly myopic patients than in the cataract control patients (fold change: 4.861, p = 0.001). miR-29a inhibited the synthesis of type I collagen in human SF cells and enhanced cell migration, but had no significant effect on cell proliferation. CONCLUSION: MiR-29a was highly expressed in aqueous humor of myopia patients and inhibited the synthesis of type I collagen in human SF cells in vivo, thereby it may play an important role in myopia development.


Assuntos
Colágeno Tipo I , MicroRNAs , Miopia , Catarata , Proliferação de Células , Colágeno Tipo I/genética , Colágeno Tipo I/metabolismo , Humanos , MicroRNAs/genética , Miopia/genética
5.
Front Public Health ; 9: 736617, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34926368

RESUMO

Objectives: During the coronavirus disease 2019 (COVID-19) self-quarantine period, the transition to online-course has profoundly changed the learning modes of millions of school-aged children and put them at an increased risk of asthenopia. Therefore, we aimed to determine associations of the total screen/online-course time with asthenopia prevalence among that children during the COVID-19 pandemic, and whether the associations were mediated by psychological stress. Methods: Asthenopia was defined according to a validated computer vision syndrome questionnaire (CVS-Q). We used CVS-Q to collect the frequency and intensity of 16 asthenopia-related eye symptoms of 25,781 children. Demographic features, eye care habits, visual disorders, lifestyle, psychological and environmental factors, were also collected. Results: The overall asthenopia prevalence was 12.1%, varying from 5.4 to 18.2% across grade/gender-classified subgroups. A 100-h increment of total screen/online-course time were associated with an increased risk of asthenopia by 9% [odds ratio (OR) = 1.09] and 11% (OR = 1.11), respectively. Mediation analysis showed that the proportions of total effects mediated by psychological stress were 23.5 and 38.1%, respectively. Age, female gender, having myopia or astigmatism, bad habits when watching screens were also risk factors. Conversely, keeping 34-65 cm between eyes and screen, increased rest time between classes, and increased eye exercise were all associated with a decreased risk. Conclusion: Our study indicated that the influence of long total screen or online-course time on psychological stress increases asthenopia risk. The findings of this study have provided a new avenue for intervening screen-related asthenopia in addition to incorporating a reasonable schedule of online courses into educational policy.


Assuntos
Astenopia , COVID-19 , Astenopia/epidemiologia , Astenopia/etiologia , Criança , Feminino , Humanos , Pandemias , SARS-CoV-2 , Estresse Psicológico/epidemiologia
6.
Biomed Res Int ; 2021: 8863637, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33728344

RESUMO

PURPOSE: To investigate the levels of transforming growth factor-ß (TGF-ß) in human aqueous humor (AH) and plasma (PL) of patients with myopia, and verify whether there is an association between these levels and their association with axial length (AL). METHODS: Thirty-eight myopic patients who received intraocular collamer lens (ICL) implantation were enrolled in this cross-sectional study. Patients were divided into three groups based on AL with cut-off points of 26 and 28 mm. AH and PL samples were obtained during ICL implantation surgery. The levels of TGF-ß1, TGF-ß2, and TGF-ß3 in the AH and PL samples were measured using Luminex xMAP Technology kits (Milliplex xMAP kits). The protein levels of TGF-ßs in both AH and PL samples and their relationships with AL were analyzed. RESULTS: In all, 38 patients (59 eyes) were enrolled and divided into the three groups: group A contained 7 people (10 eyes), group B contained 22 people (37 eyes), and group C contained 9 people (12 eyes). In the AH group, we detected TGF-ß1 (P 50: 19.97 pg/mL), TGF-ß2 (2446.00 pg/mL), and TGF-ß3 (26.33 pg/mL); in PL, these concentrations were 8984.00, 523.44, and 210.47 pg/mL, respectively. The levels of TGF-ß1 and TGF-ß3 in AH were positively associated with AL. None of the three isoforms in PL were related to those in AH or to AL. CONCLUSIONS: The levels of TGF-ß1 and TGF-ß3 in AH were more strongly associated with the severity of myopia than the types of TGF-ß in PL.


Assuntos
Humor Aquoso/metabolismo , Miopia/metabolismo , Miopia/patologia , Fator de Crescimento Transformador beta/metabolismo , Adolescente , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
7.
J Environ Manage ; 283: 112001, 2021 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-33497887

RESUMO

Developing efficient adsorbents with radiation stability for uranium removal from nuclear wastewater is greatly important for resource sustainability and environmental safety in manufacturing nuclear fuel. A novel adsorbent of hydrous titanium oxide-immobilized collagen fibers (HTO/CFs) with good radiation stability for UO22+ removal was developed. Results showed that the adsorption capacity of HTO/CFs for UO22+ was 1.379 mmol g-1 at 303 K and pH 5.0 when the initial concentration of UO22+ was 2.5 mmol L-1. Moreover, HTO/CFs showed high selectivity for U(VI) in bilateral mixed solution including UO22+ with another coexisting ion, such as Cl-, NO3-, Zn2+, and Mg2+. The adsorption behavior of UO22+ from radioactive wastewater on HTO/CF column was also investigated, and the breakthrough point was approximately 250 BV (bed volume). Notably, the HTO/CFs column can be rapidly regenerated by using only 4.0 BV of 0.1 mol L-1 HNO3 solution. The regenerated HTO/CFs column exhibited slight change in the breakthrough curve, suggesting its excellent reapplication ability. Furthermore, after irradiation under 60Co γ-ray at total doses of 10-350 kGy, HTO/CFs still preserved fibrous morphology and adsorption capacity, indicating significant radiation stability. These results demonstrate that HTO/CFs are industrial scalable adsorbents for the adsorptive recovery of uranium.


Assuntos
Urânio , Adsorção , Colágeno , Titânio , Águas Residuárias
8.
Biomed Res Int ; 2020: 2961742, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32596291

RESUMO

PURPOSE: The present study investigated the profiles of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) of the aqueous humor (AH) and plasma (PL) in myopia patients, to determine whether there was an association between these levels with their axial length (AL) and to investigate if MMPs/TIMPs were regulated locally or systemically. METHODS: A cross-sectional study was conducted. Thirty-nine patients (78 eyes) diagnosed with high myopia were recruited. The AL was measured using IOL Master. And the patients were divided into three groups based on their AL, Group A (AL ≤ 26 mm), Group B (26 < AL ≤ 28 mm), and Group C (AL > 28 mm). The AH in both eyes and blood samples were collected before the patients underwent implantable collamer lens surgery. In all, 78 samples of the AH and 39 samples of the PL were analyzed using MILLIPLEX map assays, followed by statistical analyses of the results. RESULTS: There were 8 patients (16 eyes) in Group A, 22 patients (44 eyes) in Group B, and 9 patients (18 eyes) in Group C. MMP-1 (p = 0.014, Β = 0.118), MMP-2 (p ≤ 0.001, Β = 0.278), MMP-9 (p ≤ 0.001, Β = 0.019), and TIMP-1 (p = 0.014, Β = 0.062) in the AH were positively associated with the AL. MMP-1 (p = 0.004, Β = 0.001) and TIMP-1 (p = 0.030, Β = 1.171) concentrations in the PL increased linearly with longer ALs. No concentration-dependent relationship was found between MMP-2 in the PL and AL. CONCLUSIONS: There was a consistent relationship between MMP-2 in the AH and AL. AL was not consistently or substantially affected by MMP-2 in the PL, indicating myopia formation was possibly a localized process. Associations among MMP-1, MMP-9, and TIMP-1 in the AH and AL were also observed.


Assuntos
Humor Aquoso/química , Comprimento Axial do Olho/patologia , Metaloproteinases da Matriz Secretadas/análise , Miopia , Inibidores Teciduais de Metaloproteinases/análise , Adolescente , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Metaloproteinases da Matriz Secretadas/sangue , Pessoa de Meia-Idade , Miopia/epidemiologia , Miopia/metabolismo , Miopia/patologia , Inibidores Teciduais de Metaloproteinases/sangue , Adulto Jovem
9.
Curr Eye Res ; 45(11): 1453-1457, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32396743

RESUMO

Purpose: To evaluate the optical quality of highly myopic eyes under light and dark conditions and correlate it with other relevant parameters. Materials and Methods: A cross-sectional, observational study was performed on 180 eyes of 90 highly myopic patients (29 males and 61 females; mean age: 27.833 ± 0.364 years [range: 18-45 years]). The modulation transfer function (MTF) cutoff frequency, Strehl ratio, objective scattering index (OSI), and predicted visual acuity (PVA; 100%, 20%, and 9%) under different lighting conditions were measured to evaluate the optical quality, which was correlated with probable relevant factors, including, axis length, spherical equivalent (SE), uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (BDVA), astigmatism, and corneal curvature. The relationship between these visual parameters and optical quality was analyzed using a generalized linear model. Results: The OSIs were 1.241 ± 0.068 and 1.515 ± 0.076; the MTF cutoff frequencies were 37.725 ± 0.559 and 30.238 ± 0.550 cpd; the Strehl ratios were 0.219 ± 0.004 and 0.175 ± 0.003; and the PVAs at 100%, 20%, and 9% were 1.257 ± 0.019 and 1.001 ± 0.018, 0.949 ± 0.017 and 0.719 ± 0.015, and 0.579 ± 0.011 and 0.439 ± 0.010, under bright and dark conditions respectively. The optical quality parameters were correlated with age, SE, BDVA, corneal astigmatism, and curvature to different degrees under different lighting conditions. Conclusions: The optical quality declined in highly myopic eyes under both bright and dark lighting conditions. SE, BDVA, corneal astigmatism, and curvature were correlated with optical quality to different degrees under different lighting conditions.


Assuntos
Visão de Cores/fisiologia , Luz , Miopia Degenerativa/fisiopatologia , Visão Noturna/fisiologia , Refração Ocular/fisiologia , Adolescente , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Acuidade Visual , Adulto Jovem
10.
Exp Eye Res ; 195: 108034, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32333905

RESUMO

PURPOSE: To characterize microRNAs (miRNAs) and their possible roles in high myopia by using next generation sequencing. METHODS: Aqueous humor samples were obtained from 25 highly myopic eyes and 25 cataract eyes at the onset of surgery. miRNA next generation sequencing and bioinformatics analyses were performed using RNA extracted from 30 samples. The remaining 20 samples were used for quantitative polymerase chain reaction validation of sequencing results. RESULTS: A total of 341 microRNAs were detected in the aqueous humor samples of highly myopic eyes; 201 miRNAs were detected in the aqueous humor samples of cataractous control eyes. A total of 249 mature miRNAs and 17 novel miRNAs were differentially expressed during myopia. Possible pathways regulated by these aberrantly expressed miRNAs included the TNF, MAPK, PI3K-Akt, and HIF-1 signaling pathways. The relative expression patterns of hsa-let-7i-5p, hsa-miR-127-3p, and hsa-miR-98-5p were confirmed by quantitative polymerase chain reaction. CONCLUSIONS: The current study provided an overall view of miRNA profiling in the aqueous humor of highly myopic eyes. These profiles may be associated with myopia pathogenesis, and are potential biomarkers.


Assuntos
Humor Aquoso/metabolismo , Perfilação da Expressão Gênica/métodos , MicroRNAs/genética , Miopia/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/metabolismo , Feminino , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Masculino , Pessoa de Meia-Idade , Miopia/metabolismo , Prognóstico , Adulto Jovem
11.
BMC Ophthalmol ; 20(1): 82, 2020 Mar 04.
Artigo em Inglês | MEDLINE | ID: mdl-32131800

RESUMO

BACKGROUND: The current study compared optical quality before and after implantation of a posterior chamber phakic intraocular lens with a central hole [V4c implantable collamer lens (ICL)] under bright and dark lighting conditions by means of the Optical Quality Analysis System™ (OQAS; Visiometrics, Terrassa, Spain). METHODS: This prospective study involved 91 eyes of 46 consecutive high myopia patients (15 males and 31 females, average spherical equivalent - 10.50 ± 0.33D) undergoing implantation of a V4c ICL. The modulation transfer function (MTF) cutoff frequency, Strehl ratio, objective scattering index (OSI), and predicted visual acuities (PVAs; 100, 20, and 9%), under different lighting conditions, were measured before and 1 week, 1 month, and 3 months after surgery. RESULTS: All optical parameters showed significant improvements, at all time points, under dark condition after surgery. We observed no significant changes in PVA 9% at 1 week (mean value 0.539, P = 0.12) or 1 month after surgery (mean value 0.573, P = 0.08) under bright condition; but all other postoperative parameters improved significantly. Comparing the two lighting conditions, the OSI decreased more under dark conditions at 1 week (P = 0.02), 1 month (P = 0.004), and 3 months (P = 0.002), but there was no significant difference in any other parameter. In addition, patients were divided into super high myopia (group S, spherical equivalent greater than - 10 D) and high myopia (group H, spherical equivalent from - 6 D to - 10 D), the group S improved significantly more than group H in all parameters, under both bright and dark conditions. CONCLUSIONS: V4c ICL implantation improved optical quality under both bright and dark lighting conditions, and had a better ability to reduce the extent of scattering in the dark. Furthermore, group S achieved greater improvement in visual quality, which should be considered by physicians before surgery.


Assuntos
Implante de Lente Intraocular/métodos , Iluminação , Miopia/cirurgia , Óptica e Fotônica , Lentes Intraoculares Fácicas , Refração Ocular/fisiologia , Acuidade Visual , Adolescente , Adulto , Biometria , Feminino , Seguimentos , Humanos , Masculino , Miopia/fisiopatologia , Período Pós-Operatório , Estudos Prospectivos , Desenho de Prótese , Adulto Jovem
12.
Retina ; 40(9): 1751-1756, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31567816

RESUMO

PURPOSE: This study evaluates the efficacy and usefulness of vitrectomy with internal limiting membrane peeling and autologous blood clot covering without gas tamponade in the treatment of macular holes (MHs). METHODS: All patients with a full-thickness MH with a minimum diameter of <600 µm and a base diameter of <1,200 µm underwent pars plana vitrectomy and internal limiting membrane peeling with autologous blood covering the MH at the end of the surgery. No fluid-air exchange or gas tamponade was performed. Postoperatively, all patients were instructed to adopt supine position overnight and thereafter any comfortable posture. RESULTS: A total of 18 eyes of 18 consecutive patients were included. The mean age of the patients (12 women and 6 men) was 59.06 ± 14.31 years (range, 21-81 years). The MHs composed of 13 idiopathic MHs, 2 MHs with high myopia (axial length > 26.5 mm), 2 traumatic MHs, and 1 MH associated with diabetic macular edema. Among them were five large MHs (minimum diameter > 400 µm). Complete MH closure was achieved in all eyes at the end of the follow-up period (range, 3-14 months). Visual acuity was significantly improved from preoperative 0.89 ± 0.41 logarithm of the minimum angle of resolution (20/155 Snellen) to 0.42 ± 0.33 logarithm of the minimum angle of resolution (20/53 Snellen) at the final visit (P < 0.001). CONCLUSION: The novel surgical protocol using vitrectomy, internal limiting membrane peeling, and autologous blood clot covering at the end of the MH surgery with limited diameters achieved highly effective closure and visual improvement and eliminated the gas tamponade and thus the associated adverse effects and the need for postoperative face-down positioning.


Assuntos
Membrana Basal/cirurgia , Perfurações Retinianas/terapia , Trombose , Vitrectomia , Adulto , Idoso , Idoso de 80 Anos ou mais , Tamponamento Interno , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Perfurações Retinianas/diagnóstico , Perfurações Retinianas/fisiopatologia , Estudos Retrospectivos , Decúbito Dorsal , Tomografia de Coerência Óptica , Acuidade Visual/fisiologia , Adulto Jovem
13.
Eur J Ophthalmol ; 30(3): 462-468, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-30845836

RESUMO

PURPOSE: To evaluate the vault change and anterior segment movement induced by mydriasis in moderate-to-high myopic eyes with implantable collamer lenses (ICL). SETTING: Shanghai, China. DESIGN: A prospective consecutive observational study. METHODS: A total of 45 eyes of 24 patients with ICL V4 implantation and 128 eyes of 65 patients with ICL V4c implantation were included and analyzed. Anterior chamber depth, posterior corneal endothelium-to-ICL distance, and vault before and after mydriasis were measured by Pentacam (Oculus, Wetzlar, Germany) at 1, 3, and 6 months after surgery. RESULTS: Significant vault increases and anterior chamber depth increases induced by mydriasis were noted in both ICL V4 and V4c groups at 1, 3, and 6 months postoperatively. The corneal endothelium-ICL distance increased significantly in eyes with implanted ICL V4c after mydriasis at 3 and 6 months. Moreover, mydriasis-induced vault increases were greater in the ICL V4 group than in the ICL V4c group at 3 and 6 months. In eyes with implanted ICL V4c, mydriasis-induced vault increases were significantly greater at 1 month than at 3 and 6 months. CONCLUSION: Mydriasis results in a general vault increase in eyes with implanted ICLs. The adjustment of the pressure equilibrium via the central hole of the ICL V4c has an important role in vault change. The mydriasis-induced vault increases tend toward stability after 3 months postoperatively. Mydriasis is relatively safe in eyes with ICL implantation.


Assuntos
Implante de Lente Intraocular , Midríase/fisiopatologia , Miopia Degenerativa/fisiopatologia , Miopia Degenerativa/cirurgia , Lentes Intraoculares Fácicas , Adolescente , Adulto , Câmara Anterior/patologia , Endotélio Corneano , Feminino , Humanos , Pressão Intraocular/fisiologia , Iridectomia/métodos , Iris/cirurgia , Lasers de Estado Sólido/uso terapêutico , Masculino , Microscopia Acústica , Miopia/fisiopatologia , Miopia/cirurgia , Estudos Prospectivos , Microscopia com Lâmpada de Fenda , Acuidade Visual/fisiologia , Adulto Jovem
14.
Eur J Ophthalmol ; 30(6): 1328-1334, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31304777

RESUMO

PURPOSE: To investigate the influence of refractive error on pupil diameters in highly myopic eyes with implantable collamer lenses. SETTING: Shanghai, China. DESIGN: A prospective consecutive observational study. METHODS: Sixty-six eyes of 66 patients that underwent ICL V4c implantation were included. Pupil diameters before and 1 week, 1 month, and 3 months after surgery were measured using an automatic pupillometry system (MonCv3; Metrovision, Pérenchies, France) under four standardized illumination conditions: 0, 1, 10, and 100 cd/m2. The correlations between changes in pupil diameter and spherical equivalent values and patient age were investigated. RESULTS: Based on preoperative spherical equivalent values, included eyes were divided into a high-myopia group (-6.3 to -9.9 D (diopters)) and a super-high-myopia group (-10 to -20 D). Pupil sizes remained unchanged after surgery in the high-myopia group and decreased at 1 and 10 cd/m2 in the super-high-myopia group. A between-group comparison showed that pupils were significantly smaller in the super-high-myopia group 1 week postoperatively under all illumination conditions and remained smaller at 1 month and 3 months under 1 and 10 cd/m2 lighting conditions. Preoperative spherical equivalent values were significantly correlated with the percent decrease in pupil diameter 1 week postoperatively under 0, 1, and 10 cd/m2 illumination conditions; the greater the degree of myopia, the greater the reduction in pupil diameter. CONCLUSION: Preoperative refractive error significantly affects pupil diameter in highly myopic eyes after implantable collamer lens implantation. Pupils of super highly myopic eyes remained smaller than preoperative levels under mesopic conditions after implantable collamer lens implantation.


Assuntos
Implante de Lente Intraocular/métodos , Miopia/cirurgia , Lentes Intraoculares Fácicas , Pupila , Refração Ocular/fisiologia , Adolescente , Adulto , Feminino , Humanos , Masculino , Miopia/fisiopatologia , Estudos Prospectivos , Adulto Jovem
16.
J Cataract Refract Surg ; 45(7): 946-951, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31262483

RESUMO

PURPOSE: To determine static and dynamic pupillometry characteristics before and after implantable collamer lens (ICL) (V4 and V4c) implantation. SETTING: Shanghai, China. DESIGN: Prospective consecutive observational case series. METHODS: Patients who had either V4 or V4c ICL implantation were included in this observational study. An automatic quantitative pupillometry system (MonCv3) was used for pupillometry preoperatively and 1 week, 1 month, and 3 months after surgery. Static pupillometry measurements (pupil diameters [PDs] at 4 standardized illumination levels) and dynamic parameters (including initial PD, amplitude of contraction, latency of contraction, duration of contraction, velocity of contraction, latency of dilation, duration of dilation, and velocity of dilation) were measured. RESULTS: The study comprised 98 eyes (50 patients). Mesopic and low photopic PDs declined by 0.32 mm and 0.27 mm, respectively, at 3 months after ICL implantation; scotopic PD declined at 1 week and recovered to preoperative levels at 3 months; and high photopic PD remained unchanged. Regarding the pupil light reflex, contraction amplitude and velocity declined after surgery, whereas other dynamic parameters remained unchanged. The static and dynamic pupillary characteristics were similar between the V4 and V4c ICL groups. CONCLUSIONS: The V4 and V4c ICLs had similar influences on iris motility. ICL implantation had a miotic effect under mesopic and low photopic illumination conditions, resulting in decreases in pupil contraction amplitude and velocity in light reflexes.


Assuntos
Acomodação Ocular/fisiologia , Iris/fisiopatologia , Implante de Lente Intraocular/métodos , Visão Mesópica/fisiologia , Miopia/cirurgia , Lentes Intraoculares Fácicas , Pupila/fisiologia , Adolescente , Adulto , Feminino , Humanos , Iris/cirurgia , Masculino , Miopia/fisiopatologia , Estudos Prospectivos , Adulto Jovem
20.
BMC Ophthalmol ; 18(1): 185, 2018 Jul 28.
Artigo em Inglês | MEDLINE | ID: mdl-30055577

RESUMO

BACKGROUND: The present study aimed to assess changes in, and the factors that influence, anterior chamber volume (ACV) after implantable contact lens (ICL) implantation in high myopia eyes using a Pentacam. METHODS: The study sampled 26 high myopia patients (45 eyes) who were treated with ICL implantation. These patients were followed for an average of 4.28 months postoperatively. ACV was measured with a Pentacam preoperatively and at 3 months postoperatively. The data were analyzed by paired samples Wilcoxon signed-rank test. Generalized estimating equation (GEE) model adjusting within-patient intereye correlations in addition to Pearson's and Spearman's correlation tests were performed to determine associations. RESULTS: The mean ACV was 198.33 ± 33.08 mm3 before surgery and 118.65 ± 17.70 mm3 after surgery. A significant decrease of 79.68 mm3 (40.18%) (Z = 5.841, P <  0.001) was detected. Positive correlations were found between ACV changes and ICL central vault (r = 0.528, P <  0.001) and preoperative anterior chamber depth (ACD) (r = 0.665, P <  0.001). There were positive correlations between postoperative ACV and postoperative anterior chamber angle (ACA) at 3:00 o'clock (r = 0.448, P = 0.002) and at 9:00 o'clock (r = 0.405, P = 0.006). GEE regression model showed that postoperative ACV significantly positively correlated with preoperative ACV (P = 0.002), ACD (P = 0.002) and horizontal ACA (P = 0.005) and negatively correlated with ICL central vault (P <  0.001). CONCLUSION: Complementary to vault and ACD, ACV is a sensitive parameter with certain value of preoperative assessment and postoperative monitoring in ICL implantation.


Assuntos
Câmara Anterior/diagnóstico por imagem , Miopia/cirurgia , Lentes Intraoculares Fácicas , Segmento Posterior do Olho/cirurgia , Acuidade Visual , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Miopia/diagnóstico , Miopia/fisiopatologia , Estudos Prospectivos , Adulto Jovem
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