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1.
Artigo em Inglês | MEDLINE | ID: mdl-33185418

RESUMO

The development of highly efficient thin-film nanocomposite (TFN) membranes with superior water permeability, maintained rejection performance, and excellent antifouling capacity is critical to meeting the ever-escalating demand for fresh water. Herein, carbon dots (CDs) grafted with hyperbranched zwitterions, denoted as CDs-ZPEI0.6-10k, were first prepared by the hydrothermal treatment of citric acid in the presence of zwitterionic hyperbranched polyethylenimine (ZPEI0.6-10k) with different molecular weights (0.6, 1.8, and 10 kDa). Subsequently, the synthesized nanoparticles were introduced in membrane fabrication to form CDs-ZPEI0.6-10k-embedded TFN (TFN-CDs-ZPEI0.6-10k) membranes. The grafted shells of superhydrophilic ZPEI not only increased the chemical compatibility of CDs in the polyamide layer to suppress the formation of nonselective voids but also created a densely packed network for efficient water transportation and effective divalent salt rejection. The TFN-CDs-ZPEI10k membrane demonstrated a 2.8-fold enhancement in the permeate flux with an increased Na2SO4 rejection rate of 98.1% and improved antifouling properties than the pristine thin-film composite (TFC) membrane. This work provides an insight into the development of functionalized core-shell structured nanoparticles to effectively overcome the permeability-selectivity trade-off limitations and fouling problems in TFC membranes.

2.
Plant Sci ; 301: 110654, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33218625

RESUMO

Myo-inositol and its derivatives play vital roles in plant stress tolerance. Myo-inositol-1-phosphate synthase (MIPS) is the rate-limiting enzyme of myo-inositol biosynthesis. However, the role of apple MIPS-mediated myo-inositol biosynthesis in stress tolerance remains elusive. In this study, we found that ectopic expression of MdMIPS1 from apple increased myo-inositol content and enhanced tolerance to salt and osmotic stresses in transgenic Arabidopsis lines. In transgenic apple lines over-expressing MdMIPS1, the increased myo-inositol levels could promote accumulation of other osmoprotectants such as glucose, sucrose, galactose, and fructose, to alleviate salinity-induced osmotic stress. Also, it was shown that overexpression of MdMIPS1 enhanced salinity tolerance by improving the antioxidant system to scavenge ROS, as well as Na+ and K+ homeostasis. Taken together, our results revealed a protective role of MdMIPS1-mediated myo-inositol biosynthesis in salt tolerance by improving osmotic balance, antioxidant defense system, and ion homeostasis in apple.

3.
Clin Appl Thromb Hemost ; 26: 1076029620971041, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33141604

RESUMO

BACKGROUND: Venous thromboembolism (VTE) is an important complication in patients with malignant tumors. Its exact diagnosis and treatment are still lacking. We used a high-sensitive chemiluminescence method to detect thrombin-antithrombin III complex (TAT), plasmin-α2-plasmininhibitor complex (PIC), thrombomodulin (TM), and tissue plasminogen activator-inhibitor complex(t-PAIC) in combination with D-dimer and fibrin degradation product (FDP) to analyze their diagnostic and prognostic value in patients with malignant tumors. METHODS: In total, 870 patients with confirmed malignant tumors were included, 82 of whom had diagnosed VTE; 200 healthy individuals were classified as the control group. The TAT, PIC, TM, and t-PAIC were detected using Sysmex HISCL5000 automated analyzers, whereas FDP and D-dimer were detected using Sysmex CS5100 coagulation analyzer. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic efficiency. Survival probabilities were determined using Kaplan-Meier analysis, and multivariate analyses were performed using a Cox regression model. RESULTS: Compared with healthy controls, patients with malignant tumors showed significantly elevated TAT, PIC, TM, t-PAIC, D-dimer, and FDP. Similarly, compared with patients in the non-thrombosis group, those in the thrombosis group showed significantly elevated levels of the above mentioned markers. Logistic regression analysis showed that TAT, PIC, TM, t-PAIC, D-Dimer, and FDP were all associated with VTE. ROC analysis showed that "TAT+PIC+TM+t-PAIC+D-dimer+FDP"showed the highest sensitivity and specificity. Patients with elevated TAT, PIC, TM, and t-PAIC had a significantly shorter survival. Multivariate Cox survival analysis showed that TM and t-PAIC were significantly associated with poor prognosis. In addition, the incidence of VTE was significantly lower in patients with malignant tumors who were treated with low-molecular-weight heparin (LMWH), and their survival period was significantly longer than that of patients with malignant tumors who were not treated with LMWH. CONCLUSION: TAT, PIC, TM, and t-PAIC combined with D-dimer and FDP were better than the application of a single marker in the diagnosis of VTE in patients with malignant tumors. TAT and PIC can be used as sensitive markers in the diagnosis of VTE but not as prognostic markers. TM and t-PAIC might be independent prognostic indicators in patients with malignant tumors, regardless of the state of thrombus.

4.
Indoor Air ; 2020 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-33205466

RESUMO

In this study, 30 subjects were exposed to different combinations of air temperature (Ta :24,27,and 30°C)and CO2 level (8000, 10,000, and12,000 ppm) in a high-humidity (RH: 85%) underground climate chamber.Subjective assessments, physiological responses, and cognitive performance were investigated. The results showed thatas compared withexposure toTa =24 °C, exposure to 30 °C at all CO2 levels caused subjects to feel uncomfortably warmand experiencestronger odour intensity,while increased mental effort and greater intensity of acute health symptomswere reported. However, no significant effects of Ta ontask performance or physiological responses were found. This indicated that subjects had to exert more effort to maintain their performancein an uncomfortably warm environment.Increasing CO2 from 8000 to 12,000 ppm at all Ta caused subjects to report higher rates of headache, fatigue, agitation, and feeling depressed, although the results were statistically significant only at 24 °C and 27 °C. Thetexttyping performance and systolic blood pressure(SBP)decreased significantly at this exposure, whereasdiastolic blood pressure(DBP)and thermal discomfort increased significantly. These effects suggest higher arousal/stress. No significant interaction effect of Ta and CO2 concentration on human responses was identified.

5.
Colloids Surf B Biointerfaces ; 197: 111360, 2020 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-33011500

RESUMO

Magnesium (Mg) is well-known for its bioactivity and degradability. However, due to its low evaporation temperature and limited solubility in titanium (Ti), the fabrication of Ti-Mg composite materials remains a huge challenge. In this study, Ti-xMg (x = 0.312, 0.625, 1.25 and 2.5 wt.%) composite materials were fabricated by the combination of mechanical alloying (MA) and spark plasma sintering (SPS). Mg mainly exists as a solid solute element in the Ti matrix, while a part of it re-precipitated into the Ti matrix during the SPS process. At a low content of 0.625 wt.%, Mg could increase the mechanical strength of Ti by the co-strengthening effects of solid solution and precipitation. However, it was detrimental to material mechanical properties when its content increased to 1.25 wt.%. Being immersed in phosphate buffered solution (PBS), Ti-Mg composite materials exhibited a burst Mg2+ release behavior within the first day, and then the rates of Mg2+ release gradually decreased within the following 27 days. The results suggested that the cell viability was dependent on the content of Mg in Ti-Mg composites. The high content of the Mg (2.5 wt.%) in the Ti-Mg composite could lead to significant cytotoxicity. However, appropriate Mg content (0.312∼0.625 wt.%) could promote cell attachment, proliferation and differentiation. The Ti-0.625Mg group exhibited the best in vitro biological performance among all groups. In vivo results obtained by implanting Ti-0.625Mg composite in the femurs of rats further revealed its enhanced regenerative potential and osteointegration compared to pure Ti implant.

6.
Artigo em Inglês | MEDLINE | ID: mdl-33044934

RESUMO

Traditionally, reduced hair simulation methods are either restricted to heuristic approximations or bound to specific hairstyles. We introduce the first CNN-integrated framework for simulating various hairstyles. The approach produces visually realistic hairs with an interactive speed. To address the technical challenges, our hair simulation pipeline is designed as a two-stage process. First, we present a fully-convolutional neural interpolator as the backbone generator to compute dynamic weights for guide hair interpolation. Then, we adopt a second generator to produce fine-scale displacements to enhance the hair details. We train the neural interpolator with a dedicated loss function and the displacement generator with an adversarial discriminator. Experimental results demonstrate that our method is effective, efficient, and superior to the state-of-the-art on a wide variety of hairstyles. We further propose a performance-driven digital avatar system and an interactive hairstyle editing tool to illustrate the practical applications.

7.
Artigo em Inglês | MEDLINE | ID: mdl-33048712

RESUMO

We present ShuttleSpace, an immersive analytics system to assist experts in analyzing trajectory data in badminton. Trajectories in sports, such as the movement of players and balls, contain rich information on player behavior and thus have been widely analyzed by coaches and analysts to improve the players' performance. However, existing visual analytics systems often present the trajectories in court diagrams that are abstractions of reality, thereby causing difficulty for the experts to imagine the situation on the court and understand why the player acted in a certain way. With recent developments in immersive technologies, such as virtual reality (VR), experts gradually have the opportunity to see, feel, explore, and understand these 3D trajectories from the player's perspective. Yet, few research has studied how to support immersive analysis of sports data from such a perspective. Specific challenges are rooted in data presentation (e.g., how to seamlessly combine 2D and 3D visualizations) and interaction (e.g., how to naturally interact with data without keyboard and mouse) in VR. To address these challenges, we have worked closely with domain experts who have worked for a top national badminton team to design ShuttleSpace. Our system leverages 1) the peripheral vision to combine the 2D and 3D visualizations and 2) the VR controller to support natural interactions via a stroke metaphor. We demonstrate the effectiveness of ShuttleSpace through three case studies conducted by the experts with useful insights. We further conduct interviews with the experts whose feedback confirms that our first-person immersive analytics system is suitable and useful for analyzing badminton data.

8.
J Ethnopharmacol ; : 113462, 2020 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-33058924

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: The Tongmai Yangxin pill (TMYX) is derived from the Zhigancao decoction recorded in Shang han lun by Zhang Zhongjing during the Han dynasty. TMYX is used for the clinical treatment of chest pain, heartache, and qi-yin-deficiency coronary heart disease. Previous studies have confirmed that TMYX can improve vascular endothelial function in patients with coronary heart disease by upregulating nitric oxide activity and then regulating vascular tension. Whether TMYX can further improve myocardial NR by upregulating NO activity and then dilating blood vessels remains unclear. AIM OF THE STUDY: This study aimed to reveal whether TMYX can further improve myocardial NR by upregulating NO activity and then dilating blood vessels. The underlying cAMP/PKA and NO-cGMP signaling pathway-dependent mechanism is also explored. MATERIALS AND METHODS: The left anterior descending coronary arteries of healthy adult male SD rats were ligated to establish the NR model. TMYX (4.0 g/kg) was orally administered throughout the experiment. Cardiac function was measured through echocardiography. Thioflavin S, Evans Blue, and TTC staining were used to evaluate the NR and ischemic areas. Pathological changes in the myocardium were assessed by hematoxylin-eosin staining. An automated biochemical analyzer and kit were used to detect the activities of myocardial enzymes and myocardial oxidants, including CK, CK-MB, LDH, reactive oxygen species, superoxide dismutase, malonaldehyde, and NO. The expression levels of genes and proteins related to the cAMP/PKA and NO/cGMP signaling pathways were detected via real-time fluorescence quantitative PCR and Western blot analysis, respectively. A microvascular tension sensor was used to detect coronary artery diastolic function in vitro. RESULTS: TMYX elevated the EF, FS, LVOT peak, LVPWd and LVPWs values, decreased the LVIDd, LVIDs, LV-mass, IVSd, and LV Vols values, demonstrating cardio-protective effects, and reduced the NR and ischemic areas. Pathological staining showed that TMYX could significantly reduce inflammatory cell number and interstitial edema. The activities of CK, LDH, and MDA were reduced, NO activity was increased, and oxidative stress was suppressed after treatment with TMYX. TMYX not only enhanced the expression of Gs-α, AC, PKA, and eNOS but also increased the expression of sGC and PKG. Furthermore, TMYX treatment significantly decreased ROCK expression. We further showed that TMYX (25-200 mg/mL) relaxed isolated coronary microvessels. CONCLUSIONS: TMYX attenuates myocardial NR after ischemia and reperfusion by activating the cAMP/PKA and NO/cGMP signaling pathways, further upregulating NO activity and relaxing coronary microvessels.

9.
Phys Chem Chem Phys ; 2020 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-32901632

RESUMO

The use of organic photo-redox catalysts to initiate well-controlled photochemical reactions has aroused great interest. The development of visible light-driven photocatalytic reactions, which enable rapid and efficient synthesis of fine products, is highly desired from the perspective of being able to achieve low cost, good reversibility, and environmental friendliness. Herein, the organic photocatalytic cycle, with organic dithienophosphole (DTP) derivatives Ph-DTP and TPA-DTP as the photo-redox catalysts, and iodonium salt (Ar2I+) and ethyl 4-(dimethylamino)benzoate (EDB) as the respective acceptor and donor substrates, is fully analyzed by using density functional theory and dissociative electron transfer theory. We show that the strong redox potentials in the excited state as well as the sufficiently long-lived excited state of both DTP derivatives are a robust driving force for activating the electron acceptor Ar2I+ in the activation process. Moreover, the activation barriers of electron transfer are only 0.43-11.9 kcal mol-1 for the different activation pathways. During the deactivation process, the reaction energy profiles indicate that EDB plays a vital role in reducing DTPs˙+ to their initial states. Importantly, the activation barriers and rate constants in both activation and deactivation processes obtained in this study are better than those of classic Cu-based and metal-free Ph-PTZ-based photo-redox catalysts. The excellent performance of both DTP derivatives thus enables them to be highly efficient organic photo-redox catalysts.

11.
World J Gastroenterol ; 26(31): 4680-4693, 2020 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-32884225

RESUMO

BACKGROUND: The rare incidence of esophageal neuroendocrine carcinoma (NEC) and limited treatment experience result in insufficient clinical observations and unsuitable guidelines for its management. AIM: To investigate the prognostic value of pretreatment contrast-enhanced computed tomography (CT) characteristics in patients with esophageal NEC. METHODS: Seventy-seven esophageal NEC patients who received contrast-enhanced CT at two hospitals were enrolled in this study from June 2014 to December 2019. The clinical features and image characteristics were recorded accordingly. Univariate survival analysis was performed using the Kaplan-Meier method and log-rank test, and multivariate analysis was carried out with a Cox proportional hazards model. RESULTS: The multivariate analysis performed using the Cox proportional hazards model showed that N stage, adjuvant chemotherapy, and degree of enhancement were independent prognostic factors for overall survival (OS). Meanwhile, adjuvant chemotherapy was an independent prognostic factor for progression-free survival (PFS). The hazard ratios (HRs) of N stage, adjuvant chemotherapy, and degree of enhancement (mild vs moderate/marked) for OS were 0.426 (P = 0.024), 3.862 (P = 0.006), and 2.169/0.809 (P = 0.037), respectively. The HR of adjuvant chemotherapy for PFS was 6.432 (P < 0.001). Adjuvant chemotherapy was significantly associated with degree of enhancement (P = 0.018). CONCLUSION: Adjuvant chemotherapy is an independent prognostic factor for OS and PFS. Additionally, N stage and degree of enhancement are prognostic factors for OS in patients with esophageal NEC.

12.
Drug Des Devel Ther ; 14: 3373-3384, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32884241

RESUMO

Purpose: To investigate the effects of different doses of rocuronium on ischemia-reperfusion injury in skeletal muscle induced by tourniquet in patients undergoing elective unilateral total knee arthroplasty. Patients and Methods: A total of 90 patients undergoing elective unilateral knee arthroplasty under general anesthesia combined with femoral nerve block were randomly divided into 3 groups: normal saline group (group S), rocuronium 0.6 mg/kg group (group L), and rocuronium 1.2 mg/kg group (group H). The primary outcome was the expression of dystrophin in skeletal muscle at 60 min after ischemia. Secondary outcomes included the concentration of malondialdehyde (MDA) and neuronal nitric oxide synthase (nNOS) in blood at 5 min and 30 min after reperfusion. In addition, thigh girth at 24 h and 48 h after operation, the leaving bed time, the incidence of tourniquet-related hypertension and short-term (3 days after operation) complications (nausea and vomiting, swelling, blister, wound infection) and long-term (3 months after operation) complications (joint instability, stiffness, nerve paralysis, pain) were recorded. Main Results: The expression of dystrophin in the rocuronium group was higher than that in group S after ischemia (P <0.05). The concentration of MDA in the rocuronium 1.2 mg/kg group was lower at 30 min after reperfusion (P < 0.05). There was no significant difference in nNOS among groups at each time point (P > 0.05). The change of thigh girth was the smallest in the rocuronium 1.2 mg/kg group after operation (P<0.05). The leaving bed time was significantly earlier after operation in the rocuronium group than that in group S (P <0.05). Conclusion: Rocuronium can protect skeletal muscle from ischemia-reperfusion injury induced by tourniquet. The mechanism may be related to the fact that rocuronium can reduce the loss of dystrophin in skeletal muscle and have the effects of anti-oxidation and anti-stress. Trial Registration: The study was registered at http://www.chictr.org.cn (ChiCTR1800019221, registered on 2018-10-31).

13.
Sci Adv ; 6(38)2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32948593

RESUMO

A major challenge in three-dimensional (3D) bioprinting is the limited number of bioinks that fulfill the physicochemical requirements of printing while also providing a desirable environment for encapsulated cells. Here, we address this limitation by temporarily stabilizing bioinks with a complementary thermo-reversible gelatin network. This strategy enables the effective printing of biomaterials that would typically not meet printing requirements, with instrument parameters and structural output largely independent of the base biomaterial. This approach is demonstrated across a library of photocrosslinkable bioinks derived from natural and synthetic polymers, including gelatin, hyaluronic acid, chondroitin sulfate, dextran, alginate, chitosan, heparin, and poly(ethylene glycol). A range of complex and heterogeneous structures are printed, including soft hydrogel constructs supporting the 3D culture of astrocytes. This highly generalizable methodology expands the palette of available bioinks, allowing the biofabrication of constructs optimized to meet the biological requirements of cell culture and tissue engineering.

14.
ACS Appl Mater Interfaces ; 12(38): 42660-42668, 2020 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-32878431

RESUMO

Li-rich and Mn-based layered oxides are the most promising candidates for next-generation high energy density cathode materials. However, inherent problems including poor rate performance, continuous capacity degradation, and voltage fading hinder their commercial utilization. Herein, a lattice- and interfacial-modified Li1.2Mn0.54Co0.13Ni0.13O2 with a pristine-layered bulk structure, Na- and S-doped transition phase, and epitaxially grown Na2Mn (SO4)2 (C2/c symmetry) layer were constructed by Na2S treatment. The monoclinic Na2Mn(SO4)2 not only acts as an interface protective layer, alleviating the harmful electrode-electrolyte reactions, but also promotes formation of oxygen vacancy in the layered structure, enhancing reversibility of oxygen redox. The Na and S surface lattice doping leads to enhanced Li+ diffusion and alleviates the chance of oxygen release. With the positive effects provided by the stable interfacial layer and lattice modification, the modified cathodes with moderate Na2S treatment shows alleviated capacity and voltage decay and enhanced electrochemical kinetics. Especially, the washed cathode with 3 wt % Na2S treatment delivers a discharge specific capacity of 305 at 0.1 C and 219 mA h g-1 at 1 C, as well as 93.15% capacity retention and 88.20% voltage retention after 200 cycles at 1 C.

15.
J Cell Mol Med ; 24(20): 12008-12019, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32896989

RESUMO

The role of the LMNA gene in the development and progression of hepatocellular carcinoma (HCC) and the associated molecular mechanism is not yet clear. Therefore, the purpose of this study was to evaluate the relationship between LMNA and HCC. LMNA gene expression in normal tissues and corresponding tumours was evaluated and the Kaplan-Meier survival analysis was performed. Next, the LMNA gene was knocked out in the 293T and HepG2 cell lines using the CRISPR/Cas9 technique. Subsequently, the proliferation, migration and colony formation rate of the two LMNA knockout cell lines were analysed. Finally, the molecular mechanism affecting the tumorigenesis due to the loss of the LMNA gene was evaluated. The results showed that the LMNA gene was abnormally expressed in many tumours, and the survival rate of the HCC patients with a high expression of the LMNA gene was significantly reduced compared with the rate in patients with a low LMNA expression. The knockout of the LMNA gene in the HCC cell line HepG2 resulted in a decreased tumorigenicity, up-regulation of the P16 expression and down-regulation of the CDK1 expression. These findings suggested that LMNA might function as an oncogene in HCC and provided a potential new target for the diagnosis and treatment of HCC.

16.
Neuroimage ; 223: 117327, 2020 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-32882379

RESUMO

PURPOSE: Golden-angle single-shot PROPLLER (GA-SS-PROP) is proposed to accelerate the PROPELLER acquisition for distortion-free diffusion-weighted (DW) imaging. Acceleration is achieved by acquiring one-shot per b-value and several b-values can be acquired along a diffusion direction, where the DW signal follows a bi-exponential decay (i.e. IVIM). Sparse reconstruction is used to reconstruct full resolution DW images. Consequently, apparent diffusion coefficient (ADC) map and IVIM maps (i.e., perfusion fraction (f) and the perfusion-free diffusion coefficient (D)) are obtained simultaneously. The performance of GA-SS-PROP was demonstrated with simulation and human experiments. METHODS: A realistic numerical phantom of high-quality diffusion images of the brain was developed. The error of the reconstructed DW images and quantitative maps were compared to the ground truth. The pulse sequence was developed to acquire human brain data. For comparison, fully sampled PROPELLER and conventional single-shot echo planar imaging (SS-EPI) acquisitions were performed. RESULTS: GA-SS-PROP was 5 times faster than conventional PROPELLER acquisition with comparable image quality. The simulation demonstrated that sparse reconstruction is effective in restoring contrast and resolution. The human experiments demonstrated that GA-SS-PROP achieved superior image fidelity compared to SS-EPI for the same acquisition time and same in-plane resolution (1 × 1 mm2). CONCLUSION: GA-SS-PROP offers fast, high-resolution and distortion-free DW images. The generated quantitative maps (f, D and ADC) can provide valuable information on tissue perfusion and diffusion properties simultaneously, which are desirable in many applications, especially in oncology. As a turbo spin-echo based technique, it can be applied in most challenging regions where SS-EPI is problematic.

17.
Medicine (Baltimore) ; 99(34): e21694, 2020 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-32846786

RESUMO

BACKGROUND: We conducted a meta-analysis to summarize all available evidence from randomized controlled trial studies regarding the clinical efficacy and safety of spironolactone in patients with resistant hypertension (RH) and provided a quantitative assessment. METHODS: A systematic search of PubMed, Web of Science, Cochrane Library, Embase, and China National Knowledge Infrastructure (CNKI) databases through December 8, 2019, was performed. Randomized controlled trials randomized controlled trials meeting inclusion criteria were included to assess the effect of the addition of spironolactone on office blood pressure (BP), 24-hour ambulatory BP or adverse events in RH patients. RESULTS: Twelve trials, which enrolled a total of 1655 patients, were included in this meta-analysis. In comparison with placebo, spironolactone significantly reduced office BP (office SBP, weighted mean difference [WMD] = -20.14, 95% CI = -31.17 to -9.12, P < .001; office DBP WMD = -5.73, 95% CI = -8.13 to -3.33, P < .001) and 24-hour ambulatory BP (ASBP, WMD = -10.31, 95% CI = -12.86 to -7.76, P < .001; ADBP, WMD = -3.94, 95% CI = -5.50 to -2.37, P < .001). Compared with alternative drugs, spironolactone treatment in RH patients significantly decreased 24-hour ambulatory BP (ASBP, WMD = -6.98, 95% CI = -12.66 to -1.30, P < .05; ADBP, WMD = -3.03, 95% CI = -5.21 to -0.85, P < .001). CONCLUSION: This meta-analysis fully evaluated the antihypertensive effect of spironolactone compared with placebo, alternative drugs, renal nerve denervation and no treatment. Spironolactone can result in a substantial BP reduction in patients with RH at 3 months.


Assuntos
Diuréticos/uso terapêutico , Hipertensão/tratamento farmacológico , Espironolactona/uso terapêutico , Diuréticos/efeitos adversos , Resistência a Medicamentos , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Espironolactona/efeitos adversos , Resultado do Tratamento
18.
Appl Opt ; 59(21): 6309-6314, 2020 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-32749294

RESUMO

A tunable absorber made of a nanodisk-based metasurface is proposed to realize a narrowband shortwave-infrared (SWIR) perfect absorption. By introducing a phase-change material Ge2Sb2Te5 (GST) layer, we produce a selective and active control of the optical response. It is found that the narrowband absorption of 99.9% can be achieved for amorphous GST (aGST) with a modulation depth of 54.6% at 1931 nm, which is attributed to the strong electric dipole resonance in the germanium nanodisks. Moreover, under the aGST state, the full width at half-maximum of 22 nm can be acquired for a normal TM-polarized wave, and such a nanodisk-based absorber enables a tunable operating wavelength by adjusting the geometrical parameters to realize the spectral selectivity. In addition, the nanodisk-based metasurface nanostructure, combined with a dielectric Bragg reflector with alternately stacked SiO2 and TiO2 layers, can realize the SWIR dual-band absorption for aGST and single-band absorption for crystalline GST through the adjustment of electric and magnetic resonances. The designed absorbers have the potential applications in tunable absorption filter, thermal sensing, and optical signal processing.

19.
Reprod Biol Endocrinol ; 18(1): 89, 2020 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-32825835

RESUMO

BACKGROUND: Successful implantation and delivery require both the functional embryo and receptive endometrium in assisted reproductive technology (ART) cycles. However, little is known about embryo-endometrial interaction on live-birth. We aimed to investigate the independent effect and interaction of endometrial thickness (EMT) and embryo quality on live-birth in fresh embryo transfer (ET) cycles. METHODS: We conducted a retrospective cohort study including 15,012 ART cycles between 2013 and 2016 in three centers in China. Poisson regression with generalized estimating equations was employed to calculate relative risks (RRs) and 95% confidence intervals (CIs). We estimated the interaction of embryo quality and EMT on live-birth rate (LBR). RESULTS: The LBR per cycle was 42.8% overall. LBR increased with increasing EMT and reached a plateau (50.6 to 54.2%) when EMT was 11 mm or thicker. Embryo quality represented by cumulative score was associated with LBR independently of number of embryos transferred and EMT. LBR was not increased with thicker EMT when only Q1 cleavage-stage embryo transferred (aRR 0.95, 95%CI 0.61-1.46). LBR was not increased significantly with thicker EMT with transfer of two good-quality cleavage-stage embryos and any blastocyst combination except Q1 group. There was significant interaction between EMT and embryo quality on LBR for cleavage-stage ETs (P=0.023). CONCLUSIONS: This study demonstrated the nonlinear EMT-LBR association and the EMT cut-off value of 11 mm which may be of more clinical significance for predicting live-birth. Embryo quality is an independent prognostic tool for LBR. Our finding of significant embryo-endometrial interaction indicates combination of EMT and embryos quality might improve the prognostic value in clinical practice for live-birth in patients undergoing transfer of 1-2 fresh cleavage-stage embryos.

20.
Artigo em Inglês | MEDLINE | ID: mdl-32750646

RESUMO

Myo-inositol is a versatile compound and plays a vital role in plant growth and stress tolerance. Previously, we found that exogenous application of myo-inositol enhanced the salinity tolerance in Malus hupehensis Rehd. by enhancing myo-inositol metabolism. In this study, we found that the tonoplast-localized myo-inositol transporter 1 (MdINT1) was involved in myo-inositol accumulation and conferred salinity tolerance in apple. MdINT1 is characterized by the highest transcripts among the four apple INT-like genes and could be induced by salt stress at the transcriptional level. Also, it was shown that myo-inositol level was slightly decreased in the leaves of transgenic apple lines over-expressing MdINT1, but was significantly increased in the leaves and roots of MdINT1 silencing line. Interestingly, overexpression of MdINT1 enhanced salinity tolerance by promoting Na+ and K+ balance, antioxidant activity, and accumulation of osmoprotectants in transgenic apple lines. In contrast, under salinity conditions, the MdINT1-mediated protective roles in the antioxidant activity, homeostasis of ions and osmosis were compromised, which in turn increased the risk of salt intolerance in the MdINT1 silencing line.

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